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Graduate Seminar Announcement - Dr Julie Renner
by Ewing, Virginia G 22 Apr '13

22 Apr '13

Reminder -- Purdue University School of Chemical Engineering Graduate seminar series Dr. Julie Renner "Modular Protein Matrices for Cartilage Repair" Tuesday, April 23, 2013 9:00-10:20 a.m. FRNY G140 Reception at 8:30 a.m. in Henson Atrium Abstract: Articular cartilage degradation (osteoarthritis) is a prevalent disease in the United States. Disadvantages of current treatments include poor mechanical integrity, degradation with time, and donor site morbidity. One tissue engineering approach combines artificial proteins with the use of human mesenchymal stem cells (MSCs). This approach has potential to be minimally invasive, low-cost and long-lasting. In this work, modular proteins are designed as matrices for cartilage tissue engineering. The proteins feature mechanical domains derived from the rubber-like protein resilin and attempt to mimic the mechanical properties of natural cartilage. Bioactive domains are incorporated to interact with the MSCs. Bioactive domains derived from fibronectin are included in the resilin-based proteins, and other promising bioactive sequences are identified. Lysine residues serve as crosslinking sites. Here we report oscillatory rheology experiments where the proteins exhibit dual-phase behavior and form weak gels in response to temperature. This behavior may be useful in tissue engineering and drug-delivery applications. Crosslinking the modular proteins with tris(hydroxymethyl)phosphine results in viscoelastic hydrogels with an unconfined compressive modulus of 2400 ± 200 kPa, which is on the same order as human cartilage. A LIVE/DEAD assay demonstrates that the recombinant proteins are cytocompatible with human MSCs and a cell-spreading assay shows cells interact with the fibronectin-derived domain in a sequence-specific manner. We also investigate a short peptide derived from bone morphogenetic-2 and found that it directs proteoglycan (cartilage matrix) production in human MSCs without increasing undesired markers for bone. This suggests the peptide is a promising tool for cartilage tissue repair. Bio: Dr. Renner completed her thesis work as a National Science Foundation Graduate Research Fellow at Purdue University in the summer of 2012. Her work focused on biomaterial design and characterization. She joined Proton Energy Systems in November 2012 as Small Business Postdoctoral Research Diversity Fellow supported by the National Science foundation under Grant# IIP-1059286 to the American Society for Engineering Education. She currently works on electrolysis technology as a membrane scientist.

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Severe weather conditions expected for Tippecanoe County
by Gabriela Nagy 18 Apr '13

18 Apr '13

Dear ChE Faculty, Staff, Research Fellows and Students, I just received information that Tippecanoe County is expecting severe weather today, including being under a severe thunderstorm warning and a tornado watch. Please be aware of outdoor conditions. There are many resources available; a short list includes weather web sites, local radio stations, the Purdue home page, and the Purdue Alert text messaging system. If you have not signed up for the Purdue ALERT messaging system yet, you are strongly encouraged to do so. To sign up for Purdue Alert, please go to http://www.purdue.edu/emergency_preparedness/ and click on the “Sign Up for Text Messaging” link on the left side of the page. If the outdoor sirens will be activated, please proceed calmly to our Shelter-in-place location, which is the basement of the new wing of Forney. The route to the shelter in place location is clearly signposted on each floor with the yellow sign (see picture attached) and arrows. The routes are: the staircase in the Atrium, the one adjacent to the entrance/exit facing Physics Building and the one adjacent to the entrance/exit facing Civil Engineering Building. Please review your closest route to our shelter in place location. Thank you, Gabriela -- Gabriela Nagy, PhD Industrial Education Director ChE Safety Committee Chair School of Chemical Engineering FRNY, Room G051 Tel: (765) 496-1710; Fax: (765) 494-0805 E-mail: nagyg(a)purdue.edu

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Graduate Seminar Announcement - Dr Julie Renner
by Ewing, Virginia G 17 Apr '13

17 Apr '13

Purdue University School of Chemical Engineering Graduate seminar series Dr. Julie Renner "Modular Protein Matrices for Cartilage Repair" Tuesday, April 23, 2013 9:00-10:20 a.m. FRNY G140 Reception at 8:30 a.m. in Henson Atrium Abstract: Articular cartilage degradation (osteoarthritis) is a prevalent disease in the United States. Disadvantages of current treatments include poor mechanical integrity, degradation with time, and donor site morbidity. One tissue engineering approach combines artificial proteins with the use of human mesenchymal stem cells (MSCs). This approach has potential to be minimally invasive, low-cost and long-lasting. In this work, modular proteins are designed as matrices for cartilage tissue engineering. The proteins feature mechanical domains derived from the rubber-like protein resilin and attempt to mimic the mechanical properties of natural cartilage. Bioactive domains are incorporated to interact with the MSCs. Bioactive domains derived from fibronectin are included in the resilin-based proteins, and other promising bioactive sequences are identified. Lysine residues serve as crosslinking sites. Here we report oscillatory rheology experiments where the proteins exhibit dual-phase behavior and form weak gels in response to temperature. This behavior may be useful in tissue engineering and drug-delivery applications. Crosslinking the modular proteins with tris(hydroxymethyl)phosphine results in viscoelastic hydrogels with an unconfined compressive modulus of 2400 ± 200 kPa, which is on the same order as human cartilage. A LIVE/DEAD assay demonstrates that the recombinant proteins are cytocompatible with human MSCs and a cell-spreading assay shows cells interact with the fibronectin-derived domain in a sequence-specific manner. We also investigate a short peptide derived from bone morphogenetic-2 and found that it directs proteoglycan (cartilage matrix) production in human MSCs without increasing undesired markers for bone. This suggests the peptide is a promising tool for cartilage tissue repair. Bio: Dr. Renner completed her thesis work as a National Science Foundation Graduate Research Fellow at Purdue University in the summer of 2012. Her work focused on biomaterial design and characterization. She joined Proton Energy Systems in November 2012 as Small Business Postdoctoral Research Diversity Fellow supported by the National Science foundation under Grant# IIP-1059286 to the American Society for Engineering Education. She currently works on electrolysis technology as a membrane scientist.

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Graduate Seminar 11:30 today - Dr. Michael Doherty
by Ewing, Virginia G 17 Apr '13

17 Apr '13

REMINDER - seminar today at 11:30 a.m., room G140. Purdue University School of Chemical Engineering Graduate seminar series Prof. Michael Doherty Department of Chemical Engineering University of California, Santa Barbara "Crystals are Like People: Growth and Defects are What Make Them Interesting" Wednesday, April 17, 2013 11:30 a.m. - 12:20 p.m. FRNY G140 Abstract: There is a growing interest in predicting and controlling the size and shape of crystalline particles. Multidimensional population balances have been developed to accomplish this task but they suffer from the drawback of needing the absolute growth rate for every family of faces that may appear on the crystal surface. Such growth rates are known for only a handful of crystalline materials and prospects are bleak for extending the library of growth rate data. This raises the question of where the surface growth rates for all the families of faces will come from to drive multidimensional population balance engineering technology. One answer is "from first principles." In this lecture it will be shown how to reformulate multidimensional population balances in terms of relative growth rates and how to create first principles mechanistic models to calculate these quantities for real molecular crystals as a function of super-saturation. Bio: Michael F. Doherty is Professor of Chemical Engineering and Department Chair at the University of California Santa Barbara. He received his B.Sc. in Chemical Engineering from Imperial College, University of London in 1973, and his Ph.D. in Chemical Engineering from Trinity College, University of Cambridge in 1977. His research interests include process systems engineering with particular emphasis on crystal engineering, and separation with chemical reaction. He is the holder of four patents, has published over 200 technical papers and given over 250 invited lectures. He has received numerous honors and awards for his teaching and research, including the Alpha Chi Sigma Award for Chemical Engineering Research (2004) from the AIChE and the E. V. Murphree Award (2012) for Research in Industrial and Engineering Chemistry from the ACS. In 2008 he was named one of the "One Hundred Chemical Engineers of the Modern Era (post 1945) by the AIChE.

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Please power down computers tonight.
by Harrington, Michael P 16 Apr '13

16 Apr '13

Hi, As Jeff Valley has noted - all power will be off in the building at about 5:30 am Wednesday morning and will be off for about 30 minutes.. I would strongly suggest shutting off your computers this afternoon/evening before you leave (normally ECN deployed machines should always be left on). If you encounter computer issues in the morning please remember to send an email (if possible) to cheq(a)ecn.purdue.edu<mailto:cheq@ecn.purdue.edu> or ask someone to do it for you. Do not send me emails directly. Thanks, Mike ******************** Mike Harrington Computer Facilities Manager Chemical Engineering Purdue University 765-494-6428 mph(a)purdue.edu

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ELECTRICAL SHUTDOWN
by Valley, Jeffrey L 16 Apr '13

16 Apr '13

REMINDER- Tomorrow morning - Wednesday 17th - at 5:30 am there will be a total electrical shutdown of the building so work can be done in the electrical vault. The shutdown will last approximately 30 minutes. Please take the necessary precautions and shut down computers, equipment, instruments, etc. that could be effected by this power outage. Thank you. Jeff Valley

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Graduate Seminar Announcement - Dr. Michael Doherty
by Ewing, Virginia G 11 Apr '13

11 Apr '13

Note: both talks are in FRNY G140. Purdue University School of Chemical Engineering Graduate seminar series Prof. Michael Doherty Department of Chemical Engineering University of California, Santa Barbara "Rapid Process Design: Sorting the Wheat from the Chaff" Tuesday, April 16, 2013 9:00-10:20 a.m. FRNY G140 Reception at 8:30 a.m. in Henson Atrium Abstract: In the last two decades revolutionary changes have occurred in the field of process design. Methods are now in place for rapid process development using process synthesis techniques that replace evolutionary techniques of the past. While process synthesis is a high-risk high-reward framework, it has a proven track record of generating better processes with lower carbon footprints and lower manufacturing costs. A brief non-technical survey of new design methods will be given, along with a brief history of their troubled birth. I will present two quite interesting applications of the concepts to (1) assessing the viability of some biofuels options and investments, (2) new strategies for carbon capture and utilization via carbonate mineralization. "Crystals are Like People: Growth and Defects are What Make Them Interesting" Wednesday, April 17, 2013 11:30 a.m. - 12:20 p.m. FRNY G140 Abstract: There is a growing interest in predicting and controlling the size and shape of crystalline particles. Multidimensional population balances have been developed to accomplish this task but they suffer from the drawback of needing the absolute growth rate for every family of faces that may appear on the crystal surface. Such growth rates are known for only a handful of crystalline materials and prospects are bleak for extending the library of growth rate data. This raises the question of where the surface growth rates for all the families of faces will come from to drive multidimensional population balance engineering technology. One answer is "from first principles." In this lecture it will be shown how to reformulate multidimensional population balances in terms of relative growth rates and how to create first principles mechanistic models to calculate these quantities for real molecular crystals as a function of super-saturation. Bio: Michael F. Doherty is Professor of Chemical Engineering and Department Chair at the University of California Santa Barbara. He received his B.Sc. in Chemical Engineering from Imperial College, University of London in 1973, and his Ph.D. in Chemical Engineering from Trinity College, University of Cambridge in 1977. His research interests include process systems engineering with particular emphasis on crystal engineering, and separation with chemical reaction. He is the holder of four patents, has published over 200 technical papers and given over 250 invited lectures. He has received numerous honors and awards for his teaching and research, including the Alpha Chi Sigma Award for Chemical Engineering Research (2004) from the AIChE and the E. V. Murphree Award (2012) for Research in Industrial and Engineering Chemistry from the ACS. In 2008 he was named one of the "One Hundred Chemical Engineers of the Modern Era (post 1945) by the AIChE.

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Some printing services down Wednesday evening
by Harrington, Michael P 10 Apr '13

10 Apr '13

Hi, ECN will be performing an upgrade of ChE's print server this evening beginning at 5:30pm - it is expected to last about an hour. Those that use the print servers to print (including in the computer labs) will not be able to during this time - you will receive an error that you can't connect to the printer. -Mike Harrington ******************** Mike Harrington Computer Facilities Manager Chemical Engineering Purdue University 765-494-6428 mph(a)purdue.edu

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Seminar by Dr. Michael Ramage today
by Varma, Arvind 10 Apr '13

10 Apr '13

Dear Colleagues, I am delighted to inform that Dr. Michael Ramage (BS '66, MS '69, PhD '71, HDR '96), one of our School's most distinguished graduates, will present a special seminar today, titled "Review of Transitions to Alternative Vehicles and Fuels, NRC Report, 2013." The seminar will be held in FRNY 3059, from 12:30 - 1:30 pm. This is not a mandatory seminar but students are invited to attend. As you may be aware, over the recent years Dr. Ramage chaired several National Research Council (NRC) reports dealing with energy issues - despite being asked to chair this one, he declined to serve in this role again but did serve as a consultant. His brief biographical information is given below. Biographical Information Dr. Michael P. Ramage is retired Executive Vice-President, ExxonMobil Research and Engineering Company and currently Executive Advisor to ExxonMobil. Previously, he was Executive Vice-President, Chief Technology Officer, and Director of Mobil Oil Corporation. He has broad experience in many aspects of the petroleum, chemical and energy industries. Dr. Ramage has served on a number of university visiting committees, including our School's Industrial Advisory Council and Academic Advisory Board, and was a member of the Government University Industrial Research Roundtable. He is a member of several professional organizations, was a Director of AIChE, and served on the U.S. Secretary of Energy's Hydrogen and Fuel Cell Technical Advisory Committee since its inception in 2006 until 2010. He is a member of the National Academy of Engineering (elected 1996) and has served on the NAE Council. Some recent NRC committees which Dr. Ramage served as either chair or member are listed below. As Chair: The Hydrogen Economy: Opportunities, Costs, Barriers, and R&D Needs. Washington, D.C.: The National Academies Press (2004). Transitions to Alternative Transportation Technologies: A Focus on Hydrogen. Washington, D.C.: The National Academies Press (2008). Transitions to Alternative Transportation Technologies: Plug-in Hybrid Electric Vehicles. Washington, D.C.: The National Academies Press (2009). Liquid Transportation Fuels from Coal and Biomass: Technological Status, Costs, and Environmental Impacts. Washington, D.C.: The National Academies Press (2009). As Member: America's Energy Future: Technology and Transformation. Washington, D.C.: The National Academies Press (2009). Best, Arvind Varma R. Games Slayter Distinguished Professor Jay and Cynthia Ihlenfeld Head of Chemical Engineering Purdue University

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Purdue ChE April Newsletter: Pager System, Recycling, Printing Quota News
by Farmus, Cristina D 08 Apr '13

08 Apr '13

Change in Pager System for Jeff Valley and Jason Davenport * The University discontinued the use of pagers as we knew it. A new system is available and now there are new numbers to use. To reach Jason Davenport for shipping, deliveries, printing and copy jobs, call 765-420-2430. To reach Jeff Valley for any building related items, please call 765-420-2395. When you call, you only have the option to enter the phone number where a call can be returned, followed by the # sign. There is no voice option anymore. Faculty Recognition * Rakesh Agrawal, the Winthrop E. Stone Distinguished Professor of Chemical Engineering, received an IIT-Kanpur Distinguished Alumnus award for his outstanding contributions to research and development in Chemical Engineering. The Distinguished Alumnus Award (DAA) is the highest award instituted by the Board of Governors, Indian Institute of Technology Kanpur for its alumni in recognition of their outstanding achievements. * Stephen Beaudoin, Professor of Chemical Engineering, has been elected an honorary member of the Purdue Alpha Lambda Delta Phi Eta Sigma. Alpha Lambda Delta and Phi Eta Sigma are two of the oldest and most prestigious national honor societies on the Purdue University Campus. * Sangtae Kim, Distinguished Professor of Mechanical and Chemical Engineering, has received the 2013 Ho-Am Engineering Prize from Korea, that nation's highest engineering research award. Currently on leave from Purdue, Kim is serving as a visiting professor of chemical engineering at the University of Wisconsin-Madison. * Doraiswami Ramkrishna, the H.C. Peffer Distinguished Professor of Chemical Engineering, is the winner of the 2013 Purdue Sigma Xi Chapter Faculty Research Award. The award recognizes outstanding research achievement and contributions to scientific knowledge by a Purdue faculty member. Graduate Student Recognition * David Acevedo received a 2013 National Science Foundation Graduate Research Program Fellowship. * Charles Hages received a Travel Award for the Energy Materials Forum - MRS 2013<https://engineering.purdue.edu/ChE/AboutUs/News/graduate-student-charles-ha…>. * Singh Meenesh received the 2013 College of Engineering Outstanding Research Award<https://engineering.purdue.edu/ChE/AboutUs/News/meenesh-singh-receives-coll…>. * Sara Yohe received a 2013 Kokes Award for the 23rd North American Catalysis Society<https://engineering.purdue.edu/ChE/AboutUs/News/graduate-student-sara-yohe-…>. Undergraduate Student Recognition * The AIChE ChemE Car placed 5th out of about 15 cars at the 2013 North Central Student Regional AIChE conference that took place March 22-24, 2013 in Cincinnati. This qualified them for national competition, which will take place in San Francisco, November 3-8, 2013. The ChemE car team, advised by Professor Mike Harris, is really excited about remodeling and improving the car for the national competition. * Jon Pfluger, Senior, received a 2013 National Science Foundation Graduate Research Program Fellowship Staff Recognition * The deadline for the 2013 ChE Staff Excellence Award is extended until April 15, due to the very limited number of nominations received. This is an excellent opportunity to reward one of our deserving staff members with a $1,000 award and a plaque. * Heather Toro, Business Manager, received her Department Head Delegation. In this capacity, she will be able to approve purchase orders, payroll forms, and multiple other documents, shortening the handling time for many processes in the Business Office. Miscellaneous * Printing Quota - graduate students, post docs, and other categories who have a printing quota can check their remaining printing balance by going to https://engineering.purdue.edu/ECN/MyECN/account_info. * Recycling Directions - the blue bins with the white recycling sign in each office are for recyclables only. The smaller compartment is for office paper, the main compartment is for all other recyclable items (cardboard, glass, metal, plastic). The recycling bins are emptied every Tuesday and Thursday. If you choose to have a trash can by your desk, you are assuming the responsibility of emptied it daily into the larger trash cans in the hallway. If you need one, small trash cans and bags are available for pick up in the old building basement, in front of B016. Upcoming Events * Women in ChE Seminar - April 13, 2013 * Fundamentals of Engineering Exam - April 13, 2013 * Kelly Lectures - April 16, 17, 2013 * Staff meeting - April 22, 2013 * Senior Banquet - April 25, 2013, PMU, West Faculty Lounge * EV Grand Prix - April 27, 2013 * End of Semester Appreciation Reception - May 2, 2013 * Faculty retreat - May 6, 2013 * Spring Fling - May 23, 2013 Please send me information suitable for inclusion in future newsletters. Regards, Cristina Cristina Farmus Administrative Director Chemical Engineering Purdue University 765 494 0027 cfarmus(a)purdue.edu<mailto:cfarmus@purdue.edu>

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