October 2024 - Bmegradstudents-list

[Bmeroundtable-list] BME Master's Defense Announcement for Amanda B. Wagner (J. Wallace, advisor)
by May, Sandra M 31 Oct '24

31 Oct '24

BME Master's Defense Announcement for Amanda B. Wagner (J. Wallace, advisor) Everyone is invited to attend the public presentation beginning at 11AM. Title: Metformin Does Not Protect Against Bone Loss or Mechanical Deficiencies in a Streptozotocin-Induced Mouse Model of Diabetes Date: Thursday, November 14 Time: 11AM Location: SL220A (invite only) and Zoom (https://purdue-edu.zoom.us/j/93908658334<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…>) Committee Members: Joey Wallace (chair), Rachel Surowiec, Matt Allen Abstract: The prevalence of diabetes is increasing worldwide. A negative effect of poor diabetes management is increased fracture risk. Pre-clinical research has been conducted to reduce bone fracture risk by treating skeletal deficiencies in diabetic mice with repurposed osteoporosis medications. However, this approach may not be applicable to clinical practice since patients would likely first be treated to get diabetes under control. Metformin is a drug used to treat elevated glucose levels in patients with diabetes. In the current study, male C57BL/6J mice were randomly divided into four groups: control vehicle (CV), control Metformin (CM), diabetic vehicle (DV), and diabetic Metformin (DM) to determine Metformin's effects on bone health in healthy and diseased mice. Mice were chemically induced with diabetes via streptozotocin, STZ, injections at 16 weeks of age and were treated with Metformin or vehicle starting at 20 weeks of age. Bones were harvested and underwent microcomputed tomography scans to characterize trabecular and cortical bone architecture, then were mechanically tested to failure to determine bone mechanical properties. Metformin had a negative effect in healthy mice (DM group) with only four out of 15 reaching the end of the study. It also did not improve bone health in diabetic mice compared to vehicle-treated diabetic mice. Blood glucose was not significantly changed between the DV and DM groups nor relative to CV. Results suggest that a different model of diabetes such as a high fat diet and/or a longer treatment duration would better show the true impacts of Metformin. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

1 0

[Bmeroundtable-list] BME Distinguished Research Seminar, Wed., Nov. 6
by Gelfand, Johanna K 31 Oct '24

31 Oct '24

[A close up of a sign Description automatically generated] BME DISTINGUISHED RESEARCH SEMINAR SERIES November 06, 2024 9:30-10:20 am, MJIS 1001 and via ZOOM ZOOM LINK: https://purdue-edu.zoom.us/j/92740889745?pwd=KDbLkQqhlvhpVqSAvfOptQmNklC3kw…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> *Note: Students enrolled in the seminar course are expected to attend in person. "Computational and experimental tools to understand tyrosine phosphorylation in cell signaling" [cid:image002.jpg@01DB2B9B.A26F73E0] Kristen Naegle University of Virginia Associate Professor, Department of Biomedical Engineering, Resident Faculty, Center for Public Health Genomics Member, Data Sciences Institute Abstract: Tyrosine phosphorylation, the regulated addition of a phosphate group to a tyrosine residue, is a cornerstone of cell signaling that guides the development and regulation of human tissues. The discovery of tyrosine phosphorylation (pTyr) sites in the human proteome has far outpaced our understanding of them, i.e. which enzymes they are regulated by and what the resulting effect is of phosphorylation. The Naegle lab develops computational and molecular tools to improve our knowledge of pTyr in a systems-level way, chipping away at the unknown in a manner that is faster than studying one modification on one protein at a time. This seminar is a "build-your own adventure", where I hope to share our excitement for pTyr, its importance, and the ways we integrate across computer science, mathematics, engineering, and biology to tackle the challenge. Seminar attendees will get to select the specific stories from the lab they would like to hear that span from evolutionary to structural, from network inference to machine learning, from computational to experimental, and from the basic sciences to the translational impact in cancer. Bio: Kristen M. Naegle is an associate professor of Biomedical Engineering and the Department of Genome Sciences at the University of Virginia. Dr. Naegle was assistant professor of Biomedical Engineering and Computer Science and Engineering (courtesy appointment) at Washington University in St. Louis from 2012 to 2018. Dr. Naegle received her Ph.D. in 2010 from the Massachusetts Institute of Technology in Biological Engineering and was subsequently trained as a postdoctoral associate at the Koch Institute for Integrative Cancer Research. Prior to her Ph.D. training, Dr. Naegle earned a B.S. and a M.S. in Electrical Engineering from University of Washington. Her lab builds molecular and computational tools to understand the role of tyrosine phosphorylation within proteins and protein networks. Dr. Naegle's work has been funded by the NCI, NIGMS, and NAIAD. ~ BME Host: Tami Kinzer-Ursem/cohost: Elsje Pienaar~ -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

1 0

2024 National NIH K12 DiabDocs Program LOI Announcement and Event Recordings
by Gelfand, Johanna K 31 Oct '24

31 Oct '24

From: Komal Dasani <kdasani(a)stanford.edu<mailto:kdasani@stanford.edu>> Sent: Tuesday, October 29, 2024 3:52 PM To: Komal Dasani <kdasani(a)stanford.edu<mailto:kdasani@stanford.edu>> Subject: [External] 2024 National NIH K12 DiabDocs Program LOI Announcement and Event Recordings Importance: High This message was sent from a non-IU address. Please exercise caution when clicking links or opening attachments from external sources. [cid:image001.png@01DB2B70.07564F30] 2024 National NIH K12 DiabDocs Program LOI Announcement *If you know of a trainee or early-career physician-scientist, who will benefit from the information below, please feel free to forward them this email.* Hello Everyone, We hope this email finds you well! We are excited to share that the DiabDocs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmed.stanf…> program is now soliciting a fourth cycle of letters of intent for applications for our mentored career development program from early career physician scientists engaged in research relevant to diabetes and within the scope of NIDDK including basic, translational, clinical, epidemiology/biostatistical, informatics, health services or health policy projects. Most funded scholars will focus on type 1 diabetes (T1D) research, and limited slots are available for persons working in type 2 diabetes (T2D). The letters of intent (LOIs) are due on Tuesday, November 12, 2024, at 5pm (ET) via the REDCap form: https://redcap.link/x7upmzv7<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fredcap.li…> After reviewing the LOIs, individuals will be invited to submit full applications by Monday, January 13, 2025, at 5pm (ET) and an in-person program retreat in Baltimore, MD between March 5-6, 2025, that will include interviews. Award funding will begin on July 1, 2025. Please feel free to distribute the LOI Announcement to your contacts and let us know where you have disseminated the information. In addition, please find attached the eligibility criteria for program scholars for your review and records. The verbiage comes from the NIH funding opportunity announcement (FOA) statement. Resubmission Guidelines: * For applicants resubmitting their proposal, a LOI must be received by November 12, 2024, to show interest in the program. * LOI must include: 1) the original AIMS/Research Plan pages from the original full application and 2) a revised AIMS/Research Plan page demonstrating how the applicant intends to improve the proposal. * In addition, if invited to submit a full application, applicants must submit a 1-page response to the comments/feedback received from the study section in the previous recruitment cycle. The 1-page response would be required at the full application stage and not the LOI stage. DiabDocs Informational Webinars We had two informational webinars in October 2024 to discuss the program, application process and eligibility criteria. The webinars were on Zoom and recordings are linked below. Webinar slides attached to email. Wednesday, October 9, 2024: Recording available here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fstanford.…> Passcode: pJ?2CMyZ Tuesday , October 22, 2024: Recording available here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fstanford.…> Passcode: m?&4FLp6 Our program website<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmed.stanf…> has been updated with the webinar recordings, slides and additional resources this past week. Please continue visiting the website for more information and updates in the upcoming months. The second cohort of our National NIH K12 DiabDocs Program Scholars presented an update on their research progress at the(sugar)science virtual presentations on Zoom in September. Recordings for both presentations are available at the links below. September 24, 2024: https://youtu.be/LxickVMDKlE<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fyoutu.be%…> September 26, 2024: https://youtu.be/VeD8YHATUso<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fyoutu.be%…> the(sugar)science is an interactive digital platform founded to curate the scientific conversation among type 1 diabetes (T1D) researchers. Their goal is to expedite a cure for T1D by promoting collaboration across diverse research disciplines. To know more about the platform, please visit https://thesugarscience.org/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fus9.mailc…> Copyright (C) 2024 *Stanford University Department of Pediatrics*. All rights reserved. *You are receiving this message because you opted in at our program email.* Our mailing address is: National NIH K12 Physician Scientist DiabDocs Program 453 Quarry Rd, MC 5660, Palo Alto, CA 94304 Want to change how you receive these emails? You can update your preferences or unsubscribe by emailing the program at diabdocsk12(a)stanford.edu<mailto:diabdocsk12@stanford.edu?subject=null&body=null>

1 0

FW: SSIC - Last Chance To Register - Please Share With Students
by Gelfand, Johanna K 30 Oct '24

30 Oct '24

From: Creech, Michelle <mcreech(a)purdue.edu> Sent: Wednesday, October 30, 2024 10:40 AM To: Creech, Michelle <mcreech(a)purdue.edu> Subject: SSIC - Last Chance To Register - Please Share With Students [cid:effaffdc-fa6c-4107-90a6-e20288178ba5] Thanks! Micky Michelle (Micky) Creech Purdue Student Soybean Innovation Competition Program Manager Purdue University 225 S University Street West Lafayette, IN 47906 mcreech(a)purdue.edu<mailto:mcreech@purdue.edu> https://engineering.purdue.edu/ABE/academics/competitions

1 0

[Bmeroundtable-list] BME PhD Preliminary Exam Announcement for Fahmida Sultana Laboni (T. Kim, advisor)
by May, Sandra M 30 Oct '24

30 Oct '24

BME PhD Preliminary Exam Announcement for Fahmida Sultana Laboni (T. Kim, advisor) Everyone is invited to attend the public presentation beginning at 2:00 PM. Research Title: Morphological Transition, Blebbing and cytokinesis of Cell Driven by the Contraction of Cortical Actomyosin Networks Date: 11/13/2024 Time: 2:00 PM Location: LYNN G155 Thesis Committee Members: * Major Professor: Dr. Taeyoon Kim * Committee Members: * Dr. Tamara L. Kinzer-Ursem * Dr. Elsje Pienaar * Dr. Adrian Buganza Tepole Abstract: Cells are highly dynamic, undergoing significant changes during processes such as apoptosis, migration, and cytokinesis. Cells leverage actomyosin contractility to generate forces that produce diverse morphological changes, from membrane blebs to the furrow ingression required for cytokinesis. These transformations involve not only cortical reorganization but also the interaction of actin filaments with membrane linkers, which anchor the cortex to the cell membrane. However, the mechanisms by which these shared molecular components produce distinct morphological outcomes remain unclear. Additionally, the rapid, transient nature of bleb formation and cytokinesis poses challenges to understand the mechanisms solely through experimental methods. This study addresses this gap by using a suite of agent-based 3D computational models to examine the molecular mechanisms underlying bleb formation, cortical flow, and cytokinesis. Our computational model simulations reveal diverse cell shape changes driven by actin network dynamics. Specifically, bleb formation is initiated by F-actin fragmentation, triggered by mechanical forces within the network. We found that network tension dynamics, membrane-coupling strength, actin cross-linking protein (ACP) density, and motor protein concentration are key factors influencing bleb initiation and morphology. Simulations of the actin cytoskeleton model without a membrane show that cortical flow and bundle formation are significantly impacted by cytoskeletal properties. A minimum percolation threshold within the network is necessary to initiate cortical flow, while ACP density regulates bundle stability, and motor density determines flow speed. Using our cell-like actin cytoskeleton model, we expect to uncover the underlying mechanics of cell bleb formation and cytokinetic furrow ingression driven by cortical flow and membrane dynamics. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

1 0

[Bmeroundtable-list] Interesting seminar related to BME faculty and students this Friday.
by Gelfand, Johanna K 30 Oct '24

30 Oct '24

(Sent at the request of Chi Hwan Lee) From: Nak-seung Patrick Hyun <nhyun(a)purdue.edu<mailto:nhyun@purdue.edu>> Sent: Tuesday, October 29, 2024 4:31 PM To: Ward, Matthew Peter <mpward(a)purdue.edu<mailto:mpward@purdue.edu>>; Lee, Hyowon Hugh <hwlee(a)purdue.edu<mailto:hwlee@purdue.edu>>; Lee, Chi Hwan <lee2270(a)purdue.edu<mailto:lee2270@purdue.edu>>; Sunghee Park <park1713(a)purdue.edu<mailto:park1713@purdue.edu>> Subject: [ICON] Interesting seminar related to BME faculty and students this Friday. Hello everyone, I am an assistant professor at the ECE department, working on the control of bio-inspired robots and also the co-organizer of the ICON seminar series. I have invited Prof. Noah Cowan from Johns Hopkins University (Mechanical Engineering) this week to present a talk at the ICON weekly seminar series. Noah's research is diverse, from the science domain to engineering applications. In particular, he will present his work on the control path integration in the hippocampus area of the brain, which is thrilling to see the connection to neuroscience. I have attached the flyer. I believe this talk will be of interest to the BME faculty and students as well. Could you forward the seminar announcement to the BME mailing list? Best, Patrick ================================== Hello everyone, This is a reminder email for this week's seminar presented by Prof. Noah Cowan from Johns Hopkins University. It is one of the interdisciplinary talks on control theory, robotics, biology, and neuroscience. If you are interested in the "actual" neural pathway in the brain and how control theory can be applied, this will be a great talk. The flyer is attached to this email. For faculty who are interested in meeting with Prof. Noah Cowan, here is the link to the sign-up for the meeting: https://docs.google.com/spreadsheets/d/1NsC9hUhuGmQRBj_pSx0p_h0iTzc8Z4Bla5h…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.goog…> Title: Control and Recalibration of Path Integration in the Hippocampus Speaker: Prof. Noah Cowan (Johns Hopkins University, ME) Date: 11/01 (Friday) 3:00 pm- 4:00 pm Location: MSEE 112 Abstract: The hippocampus can be thought of as the "Simultaneous Localization and Mapping" (SLAM) center of the mammalian brain. For example, when an animal moves in a familiar environment, certain neurons in the hippocampus, called place cells, fire when the animal occupies a certain region in that environment, encoding the animals 2D position. Another subpopulation of neurons, called head direction cells, represent the animal's compass heading To continuously update the animal's position and orientation on this internal 'cognitive map', the hippocampal system integrates self-motion signals over time. External landmarks then provide feedback to correct the errors in the position estimate that would otherwise inevitably accumulate. Using a novel virtual reality apparatus, we discovered that if path integration is biased, such that the animal consistently under- or overestimates its movement through space, the landmarks (Jayakumar et al, Nature, 2019) or optic flow cues (Madhav et al, Nature Neuroscience 2024) in the environment can serve as a teaching signal for recalibration of the path integrator. Using a biophysically plausible attractor neural network model of path integration, we show that for landmark-based recalibration the path integration error, or its integral, must be encoded at the level of individual neurons in order to enable path integration recalibration (Secer et al, 2024, bioRxiv). Using this prediction, we turned back to the physiological data and discovered a rate code for error at the level of individual neurons. -- Nak-seung Patrick Hyun Assistant Professor Elmore Family School of Electrical and Computer Engineering Purdue University nhyun(a)purdue.edu<mailto:nhyun@purdue.edu> (765)496-0725 Website: nphyun.com<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fnphyun.com…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

1 0

Weldon Graduate Program Announcements October 30th, 2024
by Siemers, Tammy R 29 Oct '24

29 Oct '24

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements October 30th, 2024 * Career and Internship Opportunities * Research Training at NIH - virtual information sessions and program announcements * The Transition from Grad Student to Postdoc * Wisconsin Postdoc Expo November 6th * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Regeneron 2025 Intern, Biomedical Engineering<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Biomedical Engineer Intern/Co-op, Neuraxis<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Summer Intern, Manufacturing Engineer, Cook Medical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Biomedical Research Clinical Affairs Intern, Beckman Coulter Diagnostics<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * R&D Product Development Intern, Exact Sciences<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Quality Engineering Intern, Arthrex<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * 2025 Pharmacometrics Internship, AbbVie<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Intern, Cardiology, Saint Luke's Health System<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Biomedical Engineer Co-op, Clarapath<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Quality and Compliance Intern, Johnson & Johnson<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Co-op Intern LL, Sanofi<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * IAM, Data Scientist Intern, LabCorp<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Intern, Ochin<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> Postdoctoral Positions * NPA Website: https://careers.nationalpostdoc.org/jobs/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.n…> Full Time Positions * Biomedical Engineer II, Medtronic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Research and Development Engineer III, UCSF<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Biomedical Engineer I, Memorial Sloan Kettering Cancer Center<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Biomedical Materials and Orthopedics Testing Applications Engineer, MTS Systems<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Research Engineer, Cleveland Clinic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Clean Room Engineer, University of Oregon<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Senior Design Quality Engineer, Medtronic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Clinical Research Scientist, Apple<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Research Associate I, Antibody Engineering, Twist Biosciences<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Sustaining Engineer II, Endotronix<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Associate Engineer, Amgen<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Biomedical Designer, Orthopedics, 3D Systems<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Biomedical Engineer, Harbor Designs and Manufacturing<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Product Evaluations Engineer, BDC Laboratories<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Purdue Start-up Job Board<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurduefou…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.a…>-Association for Clinical and Translational Science * Academic Careers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Facademicc…> * Doc Jobs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.docjo…>-Jobs beyond traditional clinical and academic roles Research Training at NIH - virtual information sessions and program announcements Want to do biomedical research training at NIH? The Intramural Research Program is the internal research arm of the NIH. Our scientists, trainees, and fellows work in a collaborative research environment using cutting-edge tools to perform interdisciplinary research from the bench to the bedside. We'd like to invite you to learn about training opportunities in the NIH Intramural Research Program for college students, graduate/professional school students, and recent doctoral degree holders. * Summer Internship Program * Postbac Program * Graduate Studies * Postdoc Training The NIH OITE is hosting virtual information sessions for potential applicants to learn more about our summer internship and postbac programs. Our website<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Ftraining.n…> highlights our programs, outlines eligibility criteria, and application instructions. Learn more about the NIH<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>, take a virtual tour of our Bethesda campus<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.nih.g…>, read about research training<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>, and discover how to find NIH research groups<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>. All NIH research experiences are paid: https://www.training.nih.gov/stipends/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…> Please pass this email along! Summer Internship Program<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…> The NIH Summer Internship Program (NIH SIP) is an opportunity to spend a summer experiencing the biomedical research environment of the NIH Intramural Research Program. In addition to full-time research, all summer interns have access to career, professional, and well-being offerings. This program is for college students, community college students, and graduate students. The application opens mid-November 2024 and closes on February 19, 2025 at noon (ET) with reference letters due on February 26, 2025 at noon (ET). Some summer cohort programs have an earlier closing date. Join us for a virtual information session to learn about the NIH and our research, get tips to apply, and get answers to your questions directly from our program staff: * NIH Summer Internship Program (SIP) Application Webinar<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>; Thursday, Nov. 21, 3:00-4:00 pm ET * NIH Summer Internship Program (SIP) Application Webinar<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>; Thursday, Dec. 12, 3:00-4:00 pm ET * NIH Postbac and Summer Internship Q&A<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>; Thursday, Jan. 9, 4:00-5:00 pm ET Postbac Program<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…> Recent college graduates planning to apply to graduate or professional school can spend one or two years doing full-time research and preparing for the next step in their career. All postbacs have access to career, professional, and well-being offerings, including medical and/or graduate school advising. There are no opening/closing dates for the general postbac program, applicants are selected on a rolling basis. Also, there is the Postbac Enrichment Program (OITE-PEP)<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>, a cohort program within the broader NIH Postbac Program. In addition to having access to the resources offered to all NIH postbacs, OITE-PEP postbacs participate in intensive programming within their learning community. The OITE-PEP application opens mid-October and closes on January 10, 2025 at noon ET. Join us for a virtual information session to learn about the NIH, the Postbac program, and OITE-PEP. Hear about our research, get tips to apply, and get answers to your questions directly from our program staff: * NIH Postbac Program Application Webinar;<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…> Wednesday, Oct. 23, 4:00-5:00 pm ET * NIH PEP (Postbac Enrichment Program) Application Webinar<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>; Monday, Oct. 28, 3:00-4:00 pm ET * NIH Postbac Program Application Webinar<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>; Tuesday, Nov. 19, 4:00-5:00 pm ET * NIH Postbac Program Application Webinar<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>; Wednesday, Dec. 11, 4:00-5:00 pm ET * NIH Postbac and Summer Internship Q&A<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>; Thursday, Jan. 9, 4:00-5:00 pm ET Graduate Studies<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…> The NIH Graduate Partnerships Program (GPP) is a collaborative education program that allows PhD students to benefit from the academic resources of their university and the research and professional environment of the NIH Intramural Research Program. For more information and to apply, please visit: https://www.training.nih.gov/research-training/grads/gpp/institutional/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>. Application(s) are due by December 2, 2024, at noon ET and recommendation letters are due by December 5, 2024, at noon ET. The GPP is currently accepting applications for Fall 2025 admission in the following NIH Institutional Partnerships: * Brown University - Neuroscience * Georgetown University - Biochemistry, Molecular, and Cellular Biology * Georgetown University - Microbiology & Immunology * Georgetown University - Neuroscience * Georgetown University - Pharmacology & Physiology * Georgetown University - Tumor Biology * Johns Hopkins University - Cell, Molecular, Dev. Biology & Biophysics * University of Pennsylvania - Immunology: NIH-Track * Karolinska Institutet - Neuroscience * University College London - Neuroscience / NIMH * University of Oxford-Cambridge - PhD * University of Oxford-Cambridge - MD/PhD - Track-1 * University of Oxford-Cambridge - MD/PhD - Track-2 For more information about the GPP overall, and to learn about the Individual Partnership path which allows currently-enrolled PhD students at academic institutions worldwide to perform all or part of their dissertation research in the NIH, visit: https://www.training.nih.gov/research-training/grads/gpp/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…> Postdoc Training<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…> Recent PhDs or other doctoral degree holders have the opportunity to work in a highly collaborative research environment with leading scientists and clinicians. Postdocs pursue basic, translational, and clinical research and come from across the U.S. and around the world. There are no open/close dates for this program, applicants are selected on a rolling basis. Open positions are posted on the OITE Job Board<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>. The Transition from Grad Student to Postdoc I am Ivonne VIDAL PIZARRO, PhD, Assistant Dean for the Office of Postdoctoral Affairs at the University of Tennessee, Knoxville. We are hosting a virtual event for graduate students who are looking at a postdoc as a next step in their careers. The event will take place on Tuesday, the 12th of November, from 9-10A US ET. Students can register here: https://tiny.utk.edu/pd-grad-school-2-postdoc<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Ftiny.utk.…>. The event is on the UT calendar - The Transition from Grad Student to Postdoc - Calendar<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcalendar.…> and is described as follows: As graduate students wrap up their thesis work and consider next steps, many may consider a postdoc. This session will provide a brief presentation, which will be followed with a panel of current postdocs. Panelists will share their experiences and offer their tips and advice with ample time for questions and answers. Graduate students are welcome to attend; doctoral students in dissertation stage are the target audience. Wisconsin Postdoc Expo November 6th The Wisconsin Postdoc Expo will take place on Wednesday, November 6 from 10 am - 3 pm CT. This free virtual event will provide critical advice and resources for anyone considering a postdoc position, including graduate students and current postdocs. Sessions include: * Navigating the transition to a postdoc * Choosing and securing the right postdoc for you * Exploring the Wisconsin postdoc experience * Leveraging the postdoc experience to achieve your career goals Learn more and register for free at https://wipostdocexpo.org/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwipostdoc…> This program is produced by Medical College of Wisconsin<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Furldefens…>, Morgridge Institute for Research<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Furldefens…>, Versiti Blood Research Institute<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Furldefens…> and University of Wisconsin-Madison<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Furldefens…>. Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. October 30th Spatial Data Visualization - StoryMap (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) October 30th Successful Visual Aids (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) October 31st International Student Workshop 5: Job Offer Negotiation (CCO<https://www.cco.purdue.edu/Calendar/Event/503>) Nov. 1st Mentoring and the Dissertation Process (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 1st Postdoc Power Session: First Friday in November (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 4th Becoming a Resilient Scientist: Unit 4 - Feedback Resilience (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>) Nov. 4th Abstract Submission Deadline for 4th Annual Grad WiE Network Symposium (Submit Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>) Nov. 5th Overview of the FDA Drug Development Process Seminar Nov. 6th AI Tools for Literature Review (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 6th Networking (including LinkedIn): Small Talk, Big Opportunity (CCO<https://www.cco.purdue.edu/Calendar/Event/518>) Nov. 6th Wisconsin Postdoc Expo: Free & Virtual Event (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwipostdoc…>) Nov. 7th Healthy Eating on the Run (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 8th LinkedIn (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 11th F31/F30 Workshop Series Topic 2: "Background, Training Goals, & Mentoring" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 12th Healthy Eating on the Run (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 12th Preparing to Buy a Car (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 12th Becoming a Resilient Scientist Discussion Group for Unit 4 Nov. 12th Deadline to submit Letter of Intent (LOI) for NIH DiabDocs Program (Submit Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fredcap.st…>) Nov. 12th The Transition from Grad Student to Postdoc Virtual Presentation (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Ftennessee…>) Nov. 13th Business Databases: Ace Your Job Interview, Find Investors for Your Research Idea (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 14th Business Meal Etiquette (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 14th Conference Paper Writing and Presenting: Strategies for Success (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 15th RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 15th Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 18th Becoming a Resilient Scientist: Unit 5 - Managing Up to Maximize Mentoring Relationships (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>) Nov. 18th Managing Uncertainty During Graduate School (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 19th Debt Management (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 2nd F31/F30 Workshop Series Topic 3: "Research Strategy--Significance & Motivation" Presentation (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 6th Postdoc Power Session: First Friday in December (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 13th Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 16th F31/F30 Workshop Series Topic 3: "Research Strategy--Significance & Motivation" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 13th F31/F30 Workshop Series Topic 4: "Research Strategy Approach" Presentation (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 27th F31/F30 Workshop Series Topic 4: "Research Strategy Approach" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 31st Application deadline for Johnson & Johnson Japan Smart Healthy Aging QuickFire Challenge (Apply<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjnjinnova…>) Feb. 10th F31/F30 Workshop Series Topic 5: "Biosketch and Other Documents" Working Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 25th 4th Annual Grad WiE Network Symposium (WiE<https://www.purdue.edu/wiep/CurrentStudents/Graduate%20Women%20in%20Enginee…>) News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education BME Students (ONLY): Schedule appointments with me via BoilerConnect here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>. Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [cid:image002.png@01DB2A22.DB0E1730]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

1 0

Harvard Biophysics Graduate Program Applications (Open House & Q&A Session) Oct 29th
by Siemers, Tammy R 28 Oct '24

28 Oct '24

Dear Colleague, I am writing on behalf of the Harvard Biophysics Graduate Program about our upcoming PhD application cycle, and I hope that you will encourage your students to apply. Our program lies at the interface of the physical and biological sciences, training graduate students to apply cutting-edge experimental and theoretical approaches to biological problems. Our students work with faculty in many departments across the Faculty of Arts and Sciences and Harvard Medical School, as well as faculty at the Broad Institute and Harvard-affiliated hospitals. As a highly interdisciplinary program, we welcome applicants from a wide range of scientific backgrounds, including fields such as physics, biology, chemistry, mathematics, neuroscience, and biomedical engineering. In addition, students from groups historically underrepresented in graduate education are strongly encouraged to apply. We will be hosting a Harvard Biophysics Virtual Open House from 5-6 pm EST on October 29, 2024, where faculty on the admissions committee and current students will be available to answer questions about the program and the application process. Please ask your students to use this form to register: https://forms.gle/z9Y18zvrEMS8vrxo9<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fforms.gle…>, and we ask that they please submit any accommodation requests by October 25. The registration page also includes a link for students to submit anonymous questions in advance of the Open House, and a Zoom link for the meeting will be sent to all registrants prior to the date. Applications are due December 1, 2024, and more information on applications can be found on our website<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbiophysic…>. For candidates for whom the application fee would represent an obstacle, fee waivers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgsas.harv…> are also available. Thank you for your help in sharing this information, and we look forward to receiving applications from your students. Sincerely, Michele R. Eva Administrator, Harvard University Biophysics Graduate Program Seeley G. Mudd Bldg. Room 204c 250 Longwood Ave. Boston, MA 02115 (617) 432-3802

1 0

[Bmeroundtable-list] BME 3rd year PhD Seminar Series: Friday 11-1
by Siemers, Tammy R 28 Oct '24

28 Oct '24

[cid:image001.jpg@01DB26E9.08FB6450] BME 3rd Year Seminar Series Friday, November 1st, 2024 1:30 - 2:30 PM EST MJIS 1001 Evaluation links: Md Foysal Rabbi: https://purdue.ca1.qualtrics.com/jfe/form/SV_0xgocn3ljAGc99k<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Madhurima Patra: https://purdue.ca1.qualtrics.com/jfe/form/SV_8Bo7knZ2GnvYvdk<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Evaluation surveys should only be completed after the seminar has taken place, and only by those who attended the seminar. Title: Roles of Catch-Slip Bond Dynamics at the Cytoskeleton, Cell, and Tissue Levels Md Foysal Rabbi (Taeyoon Kim, advisor) [cid:image002.jpg@01DB26E9.08FB6450] Abstract: Cytoskeletal networks, composed of actin filaments (F-actins) interconnected by actin crosslinking proteins (ACPs), play a crucial role in cellular scaffolding and numerous physiological processes. Most ACPs in the cytoskeleton dissociate from F-actins as either catch or slip bonds, resulting in a highly adaptive and transient network capable of exhibiting structural remodeling and distinct mechanical responses. Unlike slip bonds, which weaken under tension, catch bonds strengthen and increase their lifetime under tension. Interestingly, some ACPs, such as α-actinin, can switch between these behaviors in a tension-dependent manner, functioning as catch-slip bonds. Despite prior studies showing that networks with catch-slip bonds exhibit greater mechanical strength than those with slip bonds, the underlying mechanisms remain poorly understood. In this study, using computational models, we investigated the importance of catch-slip bond dynamics at cytoskeletal, cellular, and tissue levels. First, we studied how network connectivity and the force-dependent behavior of ACPs affect network strength. We found that ACPs with the nature of catch-slip bonds are redistributed toward high-force regions, reinforcing the network, whereas ACPs with the nature of slip bonds move toward low-force regions, leading to weaker networks. Second, we demonstrated that catch-slip-bond ACPs enhance the contractile force generated by myosin motors and propagate forces over longer distances than slip-bond ACPs. This force propagation was influenced by the size and number of myosin motors; fewer and longer motors allowed networks with catch-slip-bond ACPs to withstand higher forces. Finally, we explore how catch bonds impact interactions between cells and extracellular matrices, which is essential for matrix remodeling and cell migration. Our findings provide critical insights into understanding the multi-scale roles of catch-slip bonds in biological systems, revealing how their dynamics contribute to mechanical stability, force transmission, and cellular behaviors at the cytoskeletal, cellular, and tissue levels. Neural Correlates of Spectro-Temporal Modulation Detection: Insights from Cross-Species EEG studies Madhurima Patra (Michael Heinz, advisor) [cid:image006.jpg@01DB26EA.AF7FC270] Abstract: Although listeners with sensorineural hearing loss often communicate well in quiet, they typically struggle to understand speech in noisy environments (e.g., restaurants). Natural sounds exhibit spectro-temporal variations in intensity that fluctuate simultaneously across both time and frequency domains. Selective tuning to specific spectro-temporal modulations (STMs) enhances our understanding of naturalistic sounds, and preservation of these modulations across frequency channels is essential for speech intelligibility in noise. Studying limitations of missing perceptual information is particularly important for aging populations and hearing-aid recipients. Recent studies suggest STM stimuli can provide a reliable non-language-specific predictor for speech-in-noise intelligibility, which is the basis for a recent commercial clinical test. However, the mechanistic basis for this predictive power is unknown. Our work focuses on using STM stimuli composed of dynamically modified parameters in the stimulus space for studying behavioral and electroencephalographic (EEG) signatures responsible for perceptual differences across both populations. To gain mechanistic insights, animal models (specifically chinchilla lanigera) have served as indispensable pre-clinical tools to explore auditory functions at cellular and sub-cortical levels, with experimentally controlled hearing-loss conditions. Recent development of a multi-channel mini-EEG cap used with chinchillas in a light-sedation protocol has facilitated acquiring reliable cortical responses. Leveraging this and utilizing a stimulus paradigm similar to ones used for human behavior and EEG experiments will equip us with an informative dataset to foster a comprehensive understanding of the divergent aspects of auditory processing mechanisms across both species. Preliminary data suggest variations in STM characteristics are differentially represented across various EEG frequency bands. Notably, transitions between low and high signal-to-noise ratio (SNR) stimulus blocks are encoded more efficiently than transitions between blocks with similar SNR levels. A major strength of this cross-species approach is the ability to directly link analogous responses and comparative analyses across species on a perceptual level, thus enhancing translational potential. Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

1 0

[Bmeroundtable-list] BME 3rd year PhD Seminar Series: Friday 10-25
by Rowen, Elizabeth Pearl 25 Oct '24

25 Oct '24

[cid:image001.jpg@01DB05C3.B4BD0650] BME 3rd Year Seminar Series Friday, October 25th, 2024 1:30 - 2:30 PM EST MJIS 1001 Evaluation links: Laura Nunez Alvarez: https://purdue.ca1.qualtrics.com/jfe/form/SV_38aeZ2NTMmCejH0<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Elizabeth Frazier: https://purdue.ca1.qualtrics.com/jfe/form/SV_5toy71VUvqTEs18<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Evaluation surveys should only be completed after the seminar has taken place, and only by those who attended the seminar. A Multiscale Approach to Understanding Tissue Expansion-Induced Changes in Skin Mechanics and Cellular Behavior Laura Nunez Alvarez (Adrian Buganza Tepole, advisor) [cid:image002.jpg@01DB23AB.7B8D9E20] Abstract: Breast cancer is the most diagnosed cancer in women in the US. Approximately 50% of patients opt for or are advised to undergo a mastectomy. After removal, patients can undergo Breast Reconstruction Surgery (BRS), mostly done with Tissue Expansion (TE). TE complications include necrosis, excessive asymmetry, and capsular contraction, as TE is alternated with Radiotherapy (RT). Unfortunately, little is known about the cellular processes that drive those changes and the combined effect of TE and RT on skin tissue and cells. The present study aims to quantify tissue changes, such as skin stiffness, through biaxial testing, collagen architecture changes through histology analysis, and cellular changes through protein quantification. Collected and reported data will feed a TE multiscale model to predict growth and inform BRS protocols. We will use a porcine model with applied TE and RT for mechanical testing and histology analysis. From this model, we will quantify the cellular expression of mechanoresponsive proteins such as YAP and TE-induced area growth. Moreover, we will create a 3D culture that mimics the cell environment under TE and RT to translate our results to the human case. This 3D model will have dermis-like fibrillar hydrogels and human skin cells. We will quantify protein expression, growth, and mechanical properties, as done in the animal model. We expect the nuclear YAP activation, collagen production, and proliferative activity to increase with stretching time. We also expect the hydrogel stiffness to correlate with fiber network changes. We will describe the multiscale TE dynamics with a cell signaling model linked to a tissue physical model. This study will provide a multiscale characterization of the skin tissue and cellular activity when they undergo TE. Our results will help elucidate critical factors in the BRS process that will help design better protocols to diminish adverse effects. Emergence of integrated visual motion responses across the cortical hierarchy Elizabeth Frazier (Maria Dadarlat Makin/Anne Sereno, advisors) [cid:image006.jpg@01DB23AB.7B8D9E20] Abstract: The perception of visual motion is fundamental for navigating and interacting with our surroundings. In the brain, visual motion is first detected locally by neurons in the primary visual cortex (V1), whose responses are limited to small, discrete regions of the visual field. To recognize coherent motion of larger visual scenes, like a flock of birds or the flow direction of a river, higher visual areas must integrate the spatially distinct local motion signals from V1 (e.g., movement of a single bird) into a unified global motion percept. While specific cortical regions are known to specialize in this process, it remains unclear how integrated motion signals emerge throughout the cortical network. In this study, we investigated the emergence of motion sensitivity across the visual cortex of mice using two types of motion stimuli: drifting gratings (representing local motion) and random dot kinematograms (RDKs; representing global motion). We recorded mesoscale neural responses to these stimuli using in vivo two-photon calcium imaging in mice expressing GCaMP6s, a fluorescent indicator of neuronal activity. Our results showed a gradient of motion selectivity along the cortical hierarchy, with V1 robustly responding to grating stimuli and higher visual areas exhibiting enhanced tuning to the direction of the RDKs. This gradient was matched by an increase in neural response latencies, suggesting higher visual areas may perform spatiotemporal integration of local motion into a global motion signal. Furthermore, analyses of latent neural population dynamics revealed distinct encoding patterns for the two types of motion stimuli. These findings deepen our understanding of the functional role of mouse higher visual areas in visual motion processing. Ultimately, this work has important implications for expanding the utility of mouse models in studying the maladaptive changes in visual motion perception that characterize many neurological conditions. Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

1 0