November 2024 - Bmegradstudents-list

[Bmeroundtable-list] BME PhD Defense Announcement for Sang Hoon Um (L. Green, advisor)
by May, Sandra M 05 Dec '24

05 Dec '24

BME PhD Defense Announcement for Sang Hoon Um (L. Green, advisor) Everyone is invited to attend the public presentation beginning at 10:00 am. Thesis title: BIO-MOLECULAR TRANSPORATION VIA DNA NANOPORES IN LIVE CELL SYSTEM AND THEIR BIO-APPLICATIONS Date: 12/05/2024 Time: 10:00 am Place: MJIS 2001 and Zoom link: https://purdue-edu.zoom.us/launch/chat?src=direct_chat_link&email=ums@purdu…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Faculty Advisor (Chair): Prof. Leopold Green Members: Prof. Chengde Mao Prof. Fang Huang Prof. Krishna Jayant Abstract: The utilization of DNA nanopores as synthetic channels within live cell membranes represents a significant advancement in biomedical research. These nanopores, engineered with precision and versatility, offer a promising avenue for selective and efficient transport of biomolecules across cellular barriers. Leveraging the programmability and biocompatibility of nucleotides, DNA nanopores provide tailored solutions for targeted delivery mechanisms. By overcoming various challenges inherent in cellular mechanisms and synthetic pore creation technologies, including the high dependency on endocytosis machinery, the limitations posed by the size of proteins in transmembrane processes, and the biocompatibility issues associated with current technologies used to form pores, they facilitate the transportation of diverse biomolecules, including the reliance on endocytosis machinery, size limitations of transmembrane proteins, and biocompatibility issues associated with current pore-forming technologies, DNA nanopores facilitate the transport of diverse biomolecules, such as small molecules and proteins, with notable efficacy and biocompatibility. This innovation holds immense potential for various biomedical applications, offering a sophisticated platform for advanced research and therapeutic interventions throughout various cell types including eukaryotic cells and prokaryotic cells. Through elucidating the nuanced importance and diverse applications of DNA nanopores in live cell membranes, this study contributes to the ongoing progress in biomedical science and therapeutic innovation. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] A note of thanks
by Kevin John Otto 28 Nov '24

28 Nov '24

Hello everyone, Thanksgiving is one of my favorite holidays-a time to reflect on gratitude and the blessings of the past year. It's a natural moment to pause and consider the changes and milestones we've experienced together. This past year has brought significant change for many of us. Some have started new jobs or schools, moved into new homes, welcomed new family members, while others have faced the loss of loved ones. As the ancient Greek philosopher Heraclitus said, "The only constant in life is change." Through all of life's unpredictability, I want to take a moment to express my gratitude: * I am deeply thankful for the Weldon family, especially for the warmth and kindness you've shown in welcoming me and my family as we transitioned back to Indiana. Wishing you all a joyful and meaningful Thanksgiving. Boiler Up! -- Kevin Otto, Ph.D. Dane A. Miller Head and Professor Weldon School of Biomedical Engineering [Purdue University, 150 years of Purdue Engineering] **My email may come at odd hours. My work hours may not be your work hours. Do not feel obliged to reply outside of your normal working day** -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] You're invited: BME Beats premieres Wed., Dec. 4
by Gelfand, Johanna K 27 Nov '24

27 Nov '24

Let us serenade you as you enter MJIS 1001 for the final distinguished research seminar of the semester! BME Beats will have its inaugural performance on Wednesday, December 4th, from 9:15-9:30 a.m. in the MJIS Atrium. Dean Arvind Raman has developed a new initiative celebrating the creative talents of our Purdue Engineering community - Developing a Thriving Community Through Celebrating Creative Talents. This initiative aims to celebrate and amplify the voices, creativity, and stories within our engineering community. This project brings together students, faculty, and staff through shared musical experiences, offering an inclusive and inspiring platform for expression and connection. Here in BME, we have developed "BME Beats" which will premiere in MJIS on Wednesday, December 4th from 9:15-9:30 a.m. in the MJIS Atrium. Our first performance will be by "BME: Barbershop Music Exegesis" featuring Ariel Cudworth, Director of Tippecanotes Chorus, Rex Fodrea, Department of Biological Sciences, Van Neie, Department of Physics & Astronomy, and BME's very own Jo Gelfand. Please make sure to be in the Atrum at 9:15 on Wednesday to celebrate music - and the arts - and BME. Performances will continue next semester, so stay tuned for future fun! Jo Gelfand Intra/Extramural Relations Administrator Purdue University Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 765-494-2996 jo(a)purdue.edu<mailto:jo@purdue.edu> [cid:image001.jpg@01DB40E9.B287BF40] -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME PhD Preliminary Exam Announcement for Jeffery Coulter (D. Umulis and T. Kim, co-advisors)
by May, Sandra M 26 Nov '24

26 Nov '24

BME PhD Preliminary Exam Announcement for Jeffery Coulter (D. Umulis and T. Kim, Co-advisors) Everyone is invited to attend the public presentation beginning at 3:00pm. Title: A computational analysis of CaMKII-actin networks and their influence on dendritic spine morphology Date: December 6, 2024 Time: 3:00 pm Location: MJIS 2001 Committee: Taeyoon Kim (Co-advisor), David Umulis (Co-advisor), Tamara Kinzer-Ursem, Janice Evans Abstract: Dendritic spines are small protrusions on neuronal dendrites responsible for receiving and integrating the post-synaptic signals that contribute to learning and memory formation through a process known as long-term-potentiation (LTP). The changes that occur in spines during LTP can be roughly categorized as “functional" (related to the efficiency of synaptic communication) and “structural" (related to morphological changes). While these changes are closely related and are both required for proper LTP, the molecular mechanisms underlying the structural changes are not well understood. The actin cytoskeleton is the primary system responsible for regulating spine structure and earlier work has found that calcium-calmodulin protein kinase II (CaMKII) has multiple actin binding capabilities. Disruption of CaMKII activity is linked to pathological spine morphologies and improper LTP, although, elucidating how its interactions with the actin cytoskeleton might contribute to this using existing experimental or computational procedures is challenging due to the small size and the multi-scale nature of this system. Here, we plan to test the hypothesis that CaMKII plays a structural role during LTP through its ability to both sequester monomeric G-actin and bundle filamentous F-actin to regulate spine morphology. We will use an agent-based computational model of homogeneous CaMKII-actin networks to understand the relative contributions of CaMKII sequestration and bundling to network architecture. To resolve the limitations of current computational approaches, we will also present a novel hybrid, continuum-discrete modeling framework capable of describing multi-scale biological systems, such as dendritic spines, wherein biochemical reactions are coupled with filamentous networks. Using this framework, we will consider how heterogeneity of CaMKII localization and its activation by calcium (Ca$^{2+}$) following synaptic stimulation affect spine morphology. Our work will provide insight into the structural role that CaMKII plays in LTP, as well as introduce a general computational framework for studying comparable multi-scale systems. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] Purdue HR & Procurement Deadlines and MJIS Building Holiday Updates
by Gelfand, Johanna K 25 Nov '24

25 Nov '24

Hello All. Please see the below updates on upcoming Purdue HR & procurement deadlines along with updates on the MJIS holiday Hours. Human Resources: Due to a condensed month and multiple payroll processes in December, we will be observing the following cutoff dates for offers and onboarding at Purdue, PARI, and Purdue Global: * Offers: All offers must be extended to candidates by Wednesday, Dec. 11, at 5 p.m. and accepted/fully onboarded by Friday, Dec. 13, at 5 p.m. * I-9 Onboarding: Sections 1 and 2 of the I-9 onboarding process must be completed by Friday, Dec. 13, at 5 p.m. * Onboarding Deadline: No new hires, transfers, or additional appointments will be onboarded after Friday, Dec. 13, at 5 p.m. * Requisition Posting: Requisitions received after Thursday, Dec. 19 will be posted after the winter recess. Hiring activities will resume on Thursday, Jan. 2, 2025, following the winter recess. For more information, please visit: Business @ Purdue News - November 12, 2024<https://mailimages.purdue.edu/vo/?FileID=cfe0813f-b8e6-4515-bbf7-b5a58f2993…> Procurement: Dec 2nd - New Vendor or change vendor requests. "Will continue to be processed if time allows but not guaranteed." Dec 8th - Deadline submission of Purchases requests over $10k to Central Procurement Dec 9th - Invoices/ZV60 Deadline. "Will continue to be processed if time allows but not guaranteed." Dec 17th - Last Day to check out department P-cards for purchase MJIS Building: MJIS Building hours will change for the Thanksgiving holiday: MJIS will lock on Wednesday November 27th at 5:00 pm and remain locked through 7:00 am Monday December 2nd . There will be no deliveries made to the building or loading dock on Thursday and Friday November 27th & 28th. MJIS Business hours will change to: 7:00 am -5:00 pm from Friday December 13th - Friday December 20th. MJIS will be locked for the holidays and the winter recess from Monday December 23rd - January 1st. (You will be able to access the building if you have active swipe access.) MJIS building hours will change to: 7:00 am -5:00 pm on January 2nd - January 10th . Normal business hours resuming on Monday January 13th. The Loading Dock will close for all deliveries on Friday December 20th at 3:00 pm. Deliveries will resume on Tuesday January 2nd . Please let me know if you have any additional questions. Best, Dylon Chase Business Manager Weldon School of Biomedical Engineering & Laboratory of Renewable Resources Engineering (LORRE) MJIS, 206 S Martin Jishcke Dr, West Lafayette, IN 47907 o: 765-494-2980 LinkedIn<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> [Purdue University, 150 years of Purdue Engineering] -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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2025 Midwestern Association of Graduate Schools (MAGS) Excellence in Teaching Award
by Siemers, Tammy R 22 Nov '24

22 Nov '24

Graduate students submit their application packet directly to OGSPS, but will include a letter of nomination from the department head. This application also requires a 10 minute teaching video. These videos do not need to be professional. With the end of the semester looming, these videos will need to be taken soon. Deadline for your students to submit their completed application is January 9, 2025. Sent on behalf of Dr. David Rollock, Assistant Vice Provost, Office of the Vice Provost for Graduate Students and Postdoctoral Scholars (OGSPS) Please help the graduate students of your Colleges/Schools earn fame and (a small) fortune through the 2025 Midwestern Association of Graduate Schools (MAGS) Excellence in Teaching Award! Purdue University is eligible to nominate one master's-level and one doctoral-level student for each award that includes a citation and a $750 honorarium that will be presented at the MAGS annual meeting April 2-4, 2025...in Indianapolis! To decide on our campus-wide nominees, students must submit materials to the Office of the Vice Provost for Graduate Students and Postdoctoral Scholars (OGSPS) by Thursday, January 9, 2025; 5:00 p.m. for consideration. Award Details * The 2025 Excellence in Teaching Awards will be bestowed on "...graduate students who exemplify excellence in the teaching and learning mission of our universities...[to] recognize the importance of excellence in teaching and mentoring as a component of graduate education and the preparation of graduate students for future service as college and university faculty." * Details of the Award, as well as a list of previous recipients, are available here: https://mags-net.org/excellence-in-teaching-award/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmags-net.…> * The Dean of the Graduate School/College (or designee) at each MAGS-affiliated university may select and submit the materials of one doctoral and one master's-level graduate student for these awards. * MAGS's evaluation criteria are shared here: https://mags-net.org/wp-content/uploads/2024/09/2025_MAGS_Exc_Teach_Award_E…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmags-net.…> Submission Details Graduate students wishing to be considered for this award-at the doctoral-level OR at the master's-level-must submit in a single PDF document that includes: * a letter of nomination from the student's department head * the student's current curriculum vitae * the nominee's teaching portfolio * up to six (6) pages, double spaced, 1-inch margins, with a 12-point font * an embedded link to a video (maximum of 10 minutes) showing the nominee teaching in an educational setting of a collegiate level course * for instructions on saving and submitting a suitable video, please see: https://mags-net.org/wp-content/uploads/2024/09/2025_MAGS_Exc_Teach_Award_Y…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmags-net.…> * all individuals who are identifiable in the video and over the age of 18 should complete a consent and release form, and the portfolio description of the video should indicate that these have been collected. The Use of Photographic and Vido/Film Consent and Release Form can be completed (and will be stored) online via Qualtrics here: * https://purdue.ca1.qualtrics.com/jfe/form/SV_8AZILsZOZwtg96u<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> * Since Purdue must review and select nominees' materials to be sent along to MAGS, materials should be submitted by Thursday January 9, 2025; 5:00 p.m. to * https://purdue.app.box.com/f/49439e99f50a45d59b05d606ec0811de<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ap…> Timeline toward nomination * Purdue (internal) deadline for submissions: Thursday, January 9, 2025 * Review of campus nominees: January 10-16, 2025 * Notification of campus nominees: January 17, 2025 * Completion of nomination packets (one master's-level and one doctoral-level, each including endorsement from the Vice Provost, OGSPS) and submission to MAGS: January 21, 2025 Questions? Please contact me at rollock(a)purdue.edu<mailto:rollock@purdue.edu> or 6-2775. Thanks, David Rollock

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[Bmeroundtable-list] BME 3rd Year PhD Student Seminar Series: Friday 11-22
by Rowen, Elizabeth Pearl 22 Nov '24

22 Nov '24

[cid:image001.jpg@01DB05C3.B4BD0650] BME 3rd Year Seminar Series Friday, November 22nd, 2024 1:30 - 2:30 PM EST MJIS 1001 Evaluation links: Shen Chang: https://purdue.ca1.qualtrics.com/jfe/form/SV_af6g9cIoztLdgeq<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Shahriar Zeynali: https://purdue.ca1.qualtrics.com/jfe/form/SV_0vVmSMn7xBjuebA<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Evaluation surveys should only be completed after the seminar has taken place, and only by those who attended the seminar. We appreciate those who are able to attend and provide feedback; These surveys will help us determine the recipient of the 2024 Fearnot Prize for the best presentation! Advancing Human Situational Awareness Assessment in Medical Intervention Shen Chang (Nan Kong/Renran Tian, advisors) [cid:image002.png@01DB3996.3E4A3590] Abstract: Situational awareness (SA) is a critical cognitive process that fundamentally shapes human performance in complex environments. A significant challenge exists in accurately measuring and evaluating SA, particularly in scenarios where untrained individuals must interact with advanced technologies during critical situations. Our initial research demonstrated this through analysis of human-drone interactions (HDI) in simulated emergency medical responses, where we developed an AI framework leveraging computer vision and graph embeddings to capture spatial-temporal relationships between humans, drones, and their environment. This work revealed both the power and limitations of behavior-based SA measures. Building upon these insights, we propose extending our framework through evidential learning techniques, using the NurViD dataset of nursing procedures as a validation domain. By modeling expert behavior patterns and their associated uncertainties, our proposed approach aims to quantify both the inherent variability in task execution and knowledge gaps in performance. This uncertainty-aware framework would enable objective comparison between expert and novice performance, providing a more standardized method for SA assessment. The implications of this research extend far beyond theoretical advancement-real-time SA assessment could enable adaptive coaching systems that dynamically respond to individual performance levels, transforming how we approach emergency response training and healthcare delivery. By bridging the gap between novice and expert performance through intelligent assessment and feedback, our work aims to enhance the safety and effectiveness of human-technology interactions in life-critical situations, potentially saving lives through improved emergency response capabilities and healthcare outcomes. T1 sensitivity to ferumoxytol at 3T versus 0.55T field strengths Shahriar Zeynali (Behzad Sharif/Craig Goergen, advisors) [cid:image005.jpg@01DB3996.3E4A3590] Abstract: Ferumoxytol-enhanced cardiac MRI (FE CMRI) has the potential to detect myocardial ischemia by enabling accurate assessment of changes in intra-myocardial blood volume (MBV). However, in-vivo comparison of ferumoxytol behavior at different field strengths is lacking. We analyzed and compared (a) relative myocardial and blood T1 changes in response to a range of ferumoxytol doses, (b) artifact severity on MOLLI T1 maps, in a relatively large cohort of animal studies at 0.55T and 3T. FE CMRI at 0.55T demonstrated 2.5-fold greater myocardial T1 sensitivity to ferumoxytol dose compared to 3T, with significantly reduced susceptibility image artifacts. The observed increase in ferumoxytol sensitivity at 0.55T enables dose reduction while maintaining diagnostic quality, offering a more cost-effective platform for FE CMRI. This could particularly benefit stress/rest T1 reactivity mapping where detecting subtle MBV changes is crucial. Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Weldon Graduate Program Announcements November 20th, 2024
by Siemers, Tammy R 20 Nov '24

20 Nov '24

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements November 20th, 2024 * Career and Internship Opportunities * Machine Learning Hackathon Challenge for NSF HDF ML Challenge * RSVP for Virtual Postdoc Expo at MSU on 12/13! * Distinguished Postdoctoral Fellowships in Digital Human Modeling at Stanford University * Graduate Professional Development Newsletter (November 15) * Seeking Volunteers for Food Science Study * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * R&D Co-op, Pre-clinical & Clinical Affairs, mtfbiologics<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Biomedical Engineer Co-op, Clarapath<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Vertex Pharmaceuticals Co-ops<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fvrtx.wd5.…> * Johnson & Johnson Internships<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjobs.jnj.…> Postdoctoral Positions * Research Fellow, Biomedical Engineering: Biomaterials, Tissue Engineering and Drug Delivery, Mayo Clinic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * NPA Website: https://careers.nationalpostdoc.org/jobs/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.n…> Full Time Positions * Associate R&D Engineer, Teleflex<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Clinical Engineer I, Cybersecurity, Cleveland Clinic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Process Development Engineer, Cell Culture/Upstream/Bioreactor/Downstream, Systems Ally<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Neuroscientists, UC San Francisco Academic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Purdue Start-up Job Board<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurduefou…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.a…>-Association for Clinical and Translational Science * Academic Careers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Facademicc…> * Doc Jobs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.docjo…>-Jobs beyond traditional clinical and academic roles Machine Learning Hackathon Challenge for NSF HDF ML Challenge See attached Join us for the 'Machine Learning Hackathon Challenge for NSF HDR ML Challenge' on November 26th at MJIS 2001. Register Here: https://docs.google.com/forms/d/e/1FAIpQLSfjljIEVIEx_42OJkc3qYlGAfQZT7kwuun…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.goog…> RSVP for Virtual Postdoc Expo at MSU on 12/13! [cid:image002.png@01DB3B58.208FD6E0] Distinguished Postdoctoral Fellowships in Digital Human Modeling at Stanford University A team of faculty at Stanford University, including Professors Scott Delp<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fnmbl.stan…>, Garry Gold<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fprofiles.…>, Karen Liu<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fckllab.st…>, Akshay Chaudhari<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fprofiles.…>, and Ellen Kuhl<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fbiomechani…> is accepting applications for Postdoctoral Fellows in digital human modeling. Individuals with backgrounds in biomechanics, computer science, imaging, robotics, and machine learning are welcome to apply. Our team is developing and applying biomechanics, AI, imaging, and machine learning to study how humans move to achieve athletic performance, recover from injuries, and improve health and wellbeing. Our team is supported by the Digital Athlete Moonshot of the Wu Tsai Human Performance Alliance (humanperformance.stanford.edu<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fhumanperfo…>), a major interdisciplinary initiative to study human athletic performance and health, the Mobilize Center (mobilize.stanford.edu<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fmobilize.s…>), the Restore Center (restore.stanford.edu<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Frestore.st…>), Stanford's HAI project (hai.stanford.edu<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fhai.stanfo…>), and other funding sources. We are searching for outstanding individuals to join our team and develop new methods to simulate, generate, and understand human movement. Fellows will be co-advised by two or more members of the faculty team. Funding is available to support fellows for two or more years. Fellows will have the opportunity to build an interdisciplinary scientific network, participate in mentoring graduate and undergraduate students, and present their work at international scientific meetings. Candidates must have: * A PhD in engineering, computer science, or related fields * Strong research and communication skills * Experience in development of state-of-the-art computational methods Learn more and apply now<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fnmbl.stan…> Stanford University is an affirmative action and equal opportunity employer, committed to increasing the diversity of its workforce. We encourage applications from women, members of minority groups, veterans, persons with disabilities, and others who would bring additional dimensions to the university's research and teaching mission. Graduate Professional Development Newsletter (November 15) Graduate Professional Development Newsletter (November 15)<https://mailimages.purdue.edu/vo/?FileID=9ebbf555-df9f-4655-b4ae-5c8f9a6a82…> Seeking Volunteers for Food Science Study [Image] Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. Nov. 21st Ten Minute Tune-Up: Engineering the Beat - Sponsored by IE (COE<https://engineering.purdue.edu/Engr/Academics/Graduate/Events/ten-minute-tu…>) Nov. 26th Machine Learning Hackathon Challenge for NSF HDF ML Challenge (Register Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.goog…>) Dec. 2nd F31/F30 Workshop Series Topic 3: "Research Strategy--Significance & Motivation" Presentation (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 2nd How to Find and Prepare for Fellowship Applications (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 3rd Ten Minutes of Talent (COE<https://engineering.purdue.edu/Engr/Academics/Graduate/Events/ten-minutes-o…>) Dec. 4th BME Beats - 9:15 am @ MJIS Atrium (COE<https://engineering.purdue.edu/Engr/Academics/Graduate/Events/bme-beats-spo…>) Dec. 5th Indianapolis CoE Holiday Community Sing (COE<https://engineering.purdue.edu/Engr/Academics/Graduate/Events/coe-holiday-c…>) Dec. 6th Postdoc Power Session: First Friday in December (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 11th Experiences in Epidemiology and Biostatistics (CCO<https://www.cco.purdue.edu/Calendar/Event/481>) Dec. 13th Virtual Postdoc Expo at MSU (RSVP Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpostdocs.…>) Dec. 13th Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 16th F31/F30 Workshop Series Topic 3: "Research Strategy--Significance & Motivation" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 2nd Deadline to Apply for McClintock Bioscience Postdoctoral Fellowship (Apply Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcg.sandia…>) Jan. 8th HDR Open House/Expo During Winter Break (CCO<https://www.cco.purdue.edu/Calendar/Event/692>) Jan. 13th F31/F30 Workshop Series Topic 4: "Research Strategy Approach" Presentation (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 14th Managing Uncertainty During Graduate School (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th AI Tools for Lit Reviews (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th Convert Your CV to a Resume (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th Credit - Understanding Cards & Scores (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th Getting the Mentoring You Need (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 16th The Cover Letter (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 17th Budgeting and Saving Money (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 17th Navigating the IRB Process and Submitting Your Study (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 21st Boiler Up & Intervene (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 21st Preparing for Academic Interviews (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 22nd Discovering the Treasures of Federal Legal, Legislative, and Regulatory Resources (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 22nd Personal Branding (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 23rd Debt Management (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 24th Business Databases: Ace Your Job Interview, Find Investors for Your Research/Idea (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 27th F31/F30 Workshop Series Topic 4: "Research Strategy Approach" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 27th Healthy Financial Habits (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 28th Best Practices in Research Data Management (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 28th Eating Right When Your Budget is Tight (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 28th The A-Z of the Job Search (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 28th 2024 Co-op Days Recruiting Event (CCO<https://www.cco.purdue.edu/Calendar/Event/528>) Jan. 30th Citation Management with Zotero (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 30th Interviewing Skills (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 31st Application deadline for Johnson & Johnson Japan Smart Healthy Aging QuickFire Challenge (Apply<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjnjinnova…>) Jan. 31st Let's Talk Taxes (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 31st RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 3rd Healthy Relationships (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 5th Conducting a Literature Review (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 5th Healthy Financial Habits (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 7th Credit - Understanding Cards & Scores (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 10th Research with Scite.ai (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 10th F31/F30 Workshop Series Topic 5: "Biosketch and Other Documents" Working Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 11th Combating Bias and Hate on College Campuses (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 12th Preparing to Buy a House (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 12th Retirement Planning (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 14th An Overview of ResearchRabbit (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 17th Diet, Stress, & Emotional Eating (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 18th How to Improve Your Public Speaking (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 19th Careers in Public Health (CCO<https://www.cco.purdue.edu/Calendar/Event/483>) Feb. 20th Healthy Eating on the Run (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 21st RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 24th Patent Agent Careers in Life Sciences (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 25th 4th Annual Grad WiE Network Symposium (WiE<https://www.purdue.edu/wiep/CurrentStudents/Graduate%20Women%20in%20Enginee…>) Mar. 12th Experiences in Healthcare and Public Health (CCO<https://www.cco.purdue.edu/Calendar/Event/484>) News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education BME Students (ONLY): Schedule appointments with me via BoilerConnect here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>. Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [cid:image004.png@01DB3B58.208FD6E0]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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[Bmeroundtable-list] BME PhD Preliminary Exam Announcement for Md Foysal Rabbi (T. Kim, advisor)
by May, Sandra M 19 Nov '24

19 Nov '24

BME PhD Preliminary Exam Announcement for Md Foysal Rabbi (T. Kim, advisor) Everyone is invited to attend the public presentation beginning at 10:00am. Title: Roles of Catch-Slip Bond Dynamics at the Cytoskeleton, Cell, and Tissue Levels Date: Monday, December 2, 2024 Time: 10:00 am Location: MRGN 129 / Zoom Link: https://purdue-edu.zoom.us/j/94668271827<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Thesis Committee Members: Dr. Taeyoon Kim (Chair), Dr. Sherry L. Harbin, Dr. Fang Huang, and Dr. Hector Gomez Abstract: The actin cytoskeleton, a semiflexible polymer network, serves as a critical structural and mechanical component in cells, driving processes such as migration, intracellular transport, and force generation. The mechanical resilience and adaptability of the cytoskeleton are modulated by transient protein cross-linkers, whose force-dependent dissociation dynamics dictate the network's response to external and internal stresses. Using computational modeling this work explores the interplay between cytoskeletal dynamics, myosin motor activity, and extracellular matrix (ECM) remodeling in cellular processes such as migration, invasion, and tissue remodeling. We demonstrate that cross-linkers exhibiting catch-slip bond behavior redistribute toward regions of high force, enhancing network resistance to stress and enabling myosin motors to generate greater contractile forces. In contrast, slip-bond cross-linkers migrate toward low-force regions, resulting in weaker networks. Additionally, we uncover that networks with fewer, larger myosin filaments exhibit superior mechanical stability by concentrating forces into specific regions, promoting efficient cross-linker redistribution and stress propagation. Using our cell-ECM interaction model we expect to uncover how focal adhesion dynamics and force transmission remodel the ECM anisotropically, aligning fibers radially to support invasive behavior. Enhanced catch-slip bond characteristics strengthen focal adhesion-mediated force transmission, emphasizing their role in anisotropic ECM remodeling and directional cellular processes. Together, these studies provide mechanistic insights into cytoskeletal and ECM mechanics, highlighting the synergy between molecular-scale interactions and large-scale structural organization. These findings not only deepen our understanding of cellular behavior in dynamic environments but also inform the design of biomimetic materials with tunable mechanical properties. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME PhD Preliminary Exam Announcement for Nikita Krishnan (R. Shi, advisor)
by May, Sandra M 19 Nov '24

19 Nov '24

BME PhD Preliminary Exam Announcement for Nikita Krishnan (R. Shi, advisor) Everyone is invited to attend the public presentation beginning at 1:00pm. Research Title: An in vitro Model of the Blood-Brain Barrier after Blast Traumatic Brain Injury Date, Time, Place: November 25th at 1pm, DLR 221 Zoom: https://purdue-edu.zoom.us/j/95217017704?pwd=LJ2rCXliBraUSzaZcKRxyuxDIb4Zco…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Thesis Committee Members: Dr. Riyi Shi (major professor), Dr. Daniel Suter, Dr. Estelle (Sunghee) Park, Dr. Taimoor Qazi Abstract: Blast traumatic brain injury (bTBI) is a highly-prevalent condition caused by shock waves from explosions. Even mild bTBI can increase the risk of developing neurodegenerative diseases like Alzheimer's Disease (AD), making the high prevalence of bTBI and repetitive bTBI amongst military personnel an urgent concern. A key pathological feature seen after bTBI is disruption of the blood-brain barrier (BBB), which normally functions to restrict the passage of biomolecules between the brain tissue and the systemic vasculature. After bTBI, the permeability of the BBB is temporarily increased, and the tight junction proteins (TJPs) normally present between the endothelial cells (ECs) that make up the BBB are temporarily expressed at lower levels. The disruption of the BBB and subsequent recovery of permeability and TJP expression are mediated by secondary injury mechanisms, or biochemical cascades that initiate immediately after primary mechanical exposure. Specifically, the activation of innate immune cells in the brain called microglia, which can be pro- or anti-inflammatory, and the generation of toxic lipid peroxidation product acrolein may play a critical role in mediating BBB dysfunction and recovery after bTBI. However, the exact roles of activated microglia and acrolein in post-injury BBB dysfunction have not been identified. The purpose of this thesis is to identify the effects of microglial activation state and acrolein levels on temporal BBB dynamics after mild bTBI by leveraging an in vitro model system of the cells of the BBB (ECs, astrocytes, and pericytes) and microglia. Microglial activation and acrolein levels will then be therapeutically targeted by biochemically promoting the anti-inflammatory activated microglial phenotype and reducing acrolein levels. This therapeutic approach will be investigated immediately after a single mild bTBI, after a single mild bTBI followed by a subsequent bTBI, and after multiple consecutive bTBIs. Treatment is expected to promote a quicker recovery of BBB permeability, TJP expression, and vascular stability marker expression both after a single injury and after repetitive injury. Understanding and promoting BBB recovery mechanisms after bTBI has the potential to mitigate pathology initiated or exacerbated by BBB permeability, and this could be critical to preventing severe consequences of single and repetitive mild bTBI. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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