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October 2024

5 participants
42 discussions

[Bmeroundtable-list] BME Distinguished Research Seminar, Wed., October 9
by Gelfand, Johanna K 02 Oct '24

02 Oct '24

[cid:image001.png@01DB14BF.E33AC430] BME DISTINGUISHED RESEARCH SEMINAR SERIES October 09, 2024 9:30-10:20 am, MJIS 1001 and via ZOOM ZOOM LINK: https://purdue-edu.zoom.us/j/98086785448?pwd=zVpCDmwSh8BfkyET0cnILMbppdTxbx…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> *Note: Students enrolled in the seminar course are expected to attend in person. It's all about time! Towards Personalized Modeling of the Hierarchical Structure of the Circadian Timing System [cid:image003.jpg@01DB14C2.4B2B2010] Ioannis P. Androulakis, Ph.D Biomedical Engineering Department, Chemical & Biochemical Engineering Department, Department of Surgery, RWJ Medical School, Rutgers University Abstract: Our circadian timing system, orchestrates a wide array of physiological functions, ranging from metabolic processes to immune responses. This system operates through a central pacemaker in the brain and peripheral clocks throughout the body, which together maintain synchronization with environmental cycles such as the day-night cycle. Recent advances have uncovered the molecular underpinnings of circadian clocks, with core clock genes generating self-sustained oscillations across tissues. However, modern lifestyles-marked by irregular sleep patterns, artificial light exposure, and shift work-disrupt these rhythms, increasing the risk for chronic diseases such as cardiovascular conditions, diabetes, and mood disorders. This presentation explores the hierarchical organization of the circadian system and the implications of its disruption for human health. We discuss the interplay between circadian rhythms and physiology, and how personalized models can be used to predict individual responses to environmental cues and therapeutic interventions. Furthermore, wearable technologies and large-scale epidemiological studies offer new opportunities to monitor circadian disruptions in real-world settings. We will discuss how analyzing behavioral data from actigraphy and CPAP adherence studies, this work sheds light on age-dependent chronotypes and patterns of circadian disruption across populations. These insights provide a foundation for personalized circadian health interventions aimed at optimizing lifestyle choices and therapeutic outcomes. Bio: Dr. Androulakis is a Biomedical Engineering, Chemical & Biochemical Engineering Professor at Rutgers University. He received his BS in Chemical Engineering from NTUA and his MS and Ph.D. from Purdue University. He was a research associate at Princeton University before joining ExxonMobil's Corporate Strategic Research Laboratories. In 2004 he moved back to academia. He is currently Professor in the Biomedical Engineering Department and the Chemical & Biochemical Engineering Department at Rutgers. He is also a Graduate Faculty in the Pharmaceutical Sciences in the Ernst Mario School of Pharmacy of Rutgers as well as an Adjunct Professor in the Departments of Surgery at the RWJ-Rutgers Medical School. He has published extensively in quantitative systems biology and quantitative systems pharmacology. He is a Fellow of the American Institute of Medical and Biological Engineering, the American Institute of Chemical Engineers and was recently elected Fellow of the International Society of Pharmacometrics. ~ BME Host: Matthew Ward~ Jo Gelfand Intra/Extramural Relations Administrator Purdue University Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 765-494-2996 jo(a)purdue.edu<mailto:jo@purdue.edu> [cid:image004.jpg@01DB14BF.E33AC430] -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] Special BME Seminar featuring Thomas Webster Wednesday, 10/2, at 10:30AM
by Gelfand, Johanna K 01 Oct '24

01 Oct '24

[cid:image001.jpg@01DAD39A.4C087D20] SPECIAL BME SEMINAR Wednesday, October 2, 2024 10:30 - 11:20 AM, MJIS 1001 Eliminating Implant Infection: 30,000 Nanotextured Implants in Humans with no Failure [cid:image003.jpg@01DB1412.92DEE690] Thomas J. Webster School of Biomedical Engineering and Health Sciences, Hebei University of Technology, Tianjin, China School of Engineering, Saveetha University, Chennai, India Division of Pre-College and Undergraduate Studies, Brown University, Providence, RI USA Abstract: Implant infection is rising with the U.S. Centers for Disease Control predicting one person every three seconds will die from a bacterial infection by 2050. Nanomedicine is the use of nanomaterials to improve disease prevention, detection, and treatment which has resulted in hundreds of FDA approved medical products. While nanomedicine has been around for several decades, new technological advances are pushing its boundaries. For example, this presentation will provide an over 25 year journey of commercializing nano orthopedic implants now in over 30,000 patients to date showing no signs of failure. Current orthopedic implants face a failure rate of 5 - 10% and sometimes as high as 60% for bone cancer patients. Further, Artificial Intelligence (AI) has revolutionized numerous industries to date. However, its use in nanomedicine has remained few and far between. One area that AI has significantly improved nanomedicine is through implantable sensors. This talk will present research in which implantable sensors, using AI, can learn from patient's response to implants and predict future outcomes. Such implantable sensors not only incorporate AI, but also communicate to a handheld device, and can reverse AI predicted adverse events. Examples will be given in which AI implantable sensors have been used in orthopedics to inhibit implant infection and promote prolonged bone growth. In vitro and in vivo experiments will be provided that demonstrate how AI can be used towards our advantage in nanomedicine, especially implantable sensors. Lastly, this talk will summarize recent advances in nanomedicine to both help human health and save the environment. Bio: Thomas J. Webster's (H index: 128) degrees are in chemical engineering from the University of Pittsburgh (B.S., 1995; USA) and in biomedical engineering from RPI (Ph.D., 2000; USA). He has formed over a dozen companies who have numerous FDA approved medical products currently improving human health in over 30,000 patients. His technology is also being used in commercial products to improve sustainability and renewable energy. He is currently helping those companies and serves as a professor at Brown University, Saveetha University, Hebei University of Technology, UFPI, and others. Dr. Webster has numerous awards including: 2020, World Top 2% Scientist by Citations (PLOS); 2020, SCOPUS Highly Cited Research (Top 1% Materials Science and Mixed Fields); 2021, Clarivate Top 0.1% Most Influential Researchers (Pharmacology and Toxicology); 2022, Best Materials Science Scientist by Citations (Research.com) and is a fellow of over 8 societies. Prof. Webster is a former President of the U.S. Society for Biomaterials and has over 1,350 publications to his credit with over 55,000 citations. He was recently nominated for the Nobel Prize in Chemistry. Prof. Webster also recently formed a fund to support Nigerian student research opportunities in the U.S. ~ BME Hosts: Kevin Otto and Leo Green ~ -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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