June 2022 - Bmegradstudents-list

Apply today! Postdoctoral Research Opportunities with DoD
by Siemers, Tammy R 30 Jun '22

30 Jun '22

Hi All, There are a bit too many to share in the announcements here so I thought I would send them out separately. There are a bit outside of BME as well so share with your friends! Happy "you almost made it" Holiday Weekend. Tammy From: orisedodrecruiting(a)orise.orau.gov <orisedodrecruiting(a)orise.orau.gov> Sent: Thursday, June 30, 2022 10:11 AM To: Siemers, Tammy R <tsiemers(a)purdue.edu> Subject: Apply today! Postdoctoral Research Opportunities with DoD ---- External Email: Use caution with attachments, links, or sharing data ---- [https://mcusercontent.com/d362006591b8be72fcbd58ffc/images/3a079f84-b6de-4d…] The Oak Ridge Institute for Science and Education (ORISE) is accepting applications for paid internship and fellowship opportunities<https://orise.orau.gov/dodprograms/current-research-opportunities.html> at the U.S. Department of Defense (DoD). Apply now! MRICD Synthetic/Medicinal Chemist Research Fellow - Postdoctoral <https://zintellect.com/Opportunity/Details/MRDC-MRICD-2022-0008> Location: Aberdeen Proving Ground, MD Degree: Doctoral Degree received within the last 60 months Citizenship: U.S. Citizen MRICD Medical Countermeasures involving Organophosphorus Nerve Agents (OPNA) Research<https://zintellect.com/Opportunity/Details/MRDC-MRICD-2022-0009> Location: Aberdeen Proving Ground, MD Degree: Doctoral Degree received within the last 60 months Citizenship: U.S. Citizen Science Education Research - Dual Science Education and Research Program Mentorship <https://zintellect.com/Opportunity/Details/MRMC-WRAIR-2019-0020RR> Location: Silver Spring, MD Degree: Bachelor's Degree, Master's Degree, or Doctoral Degree received within the last 60 months or currently pursuing Citizenship: U.S. Citizen or LPR Food Science Research at U.S. Army DEVCOM - Soldier Center<https://zintellect.com/Opportunity/Details/DEVCOM-SC-2022-0008> Location: Natick, MA Degree: Bachelor's Degree, Master's Degree, or Doctoral Degree received within the last 60 months or anticipated to be received by 9/1/2022 Citizenship: U.S. Citizen Postdoctoral Research in Infectious Disease Biomarkers and Diagnostics at U.S. Army Medical Research Institute of Infectious Diseases <https://zintellect.com/Opportunity/Details/USAMRIID-2022-0002> Location: Fort Detrick, MD Degree: Doctoral Degree received within the last 60 months Citizenship: U.S. Citizen Biomedical Technology Transfer Fellowship at the Walter Reed Army Institute of Research <https://zintellect.com/Opportunity/Details/MRMC-WRAIR-2020-0007RR> Location: Silver Spring, MD or Remote Degree: Master's Degree or Doctoral Degree received within the last 60 months or currently pursuing Citizenship: U.S. Citizen or LPR Data Science and Analytics Researcher at the Air Force Research Laboratory <https://zintellect.com/Opportunity/Details/AFRL-711HPW-2022-0008> Location: Dayton, OH Degree: Bachelor's Degree, Master's Degree, or Doctoral Degree received within the last 36 months Citizenship: U.S. Citizen Postdoctoral Fellowship in Human-Computer Interaction Research For Cyberspace Modeling and Simulation Training at DEVCOM-SC <https://zintellect.com/Opportunity/Details/DEVCOM-SC-2022-0004-R> Location: West Point, NY Degree: Doctoral Degree received within the last 60 months Citizenship: U.S. Citizen Human-Centered Interface Design Fellowship at the Air Force Research Laboratory <https://zintellect.com/Opportunity/Details/AFRL-711HPW-2022-0006R> Location: Dayton, OH Degree: Bachelor's Degree, Master's Degree, or Doctoral Degree received within the last 36 months or anticipated to be received by 5/30/2025 Citizenship: U.S. Citizen Postdoctoral Immunology Fellowship at The Walter Reed Army Institute of Research <https://zintellect.com/Opportunity/Details/MRMC-WRAIR-2022-0008> Location: Silver Spring, MD Degree: Doctoral Degree received within the last 48 months Citizenship: U.S. Citizen or LPR Computational Neuroscience Postdoctoral Researcher at the Air Force Research Laboratory <https://zintellect.com/Opportunity/Details/AFRL-711HPW-2022-0005> Location: San Antonio, TX Degree: Doctoral Degree received within the last 60 months Citizenship: U.S. Citizen Sleep and Chronobiology Statistician Research Fellowship at WRAIR<https://zintellect.com/Opportunity/Details/MRMC-WRAIR-2022-0006> Location: Silver Spring, MD Degree: Master's Degree or Doctoral Degree received within the last 60 months Citizenship: U.S. Citizen or LPR Biochemistry Postdoctoral Fellowship at the Walter Reed Army Institute of Research <https://zintellect.com/Opportunity/Details/MRMC-WRAIR-2022-0005> Location: Silver Spring, MD Degree: Doctoral Degree received within the last 60 months Citizenship: U.S. Citizen or LPR Air Force Research Laboratory (AFRL) - Neuroscience Postdoctoral Researcher <https://zintellect.com/Opportunity/Details/AFRL-711HPW-2022-0001> Location: Baltimore, MD Degree: Doctoral Degree received within the last 60 months Citizenship: U.S. Citizen VIEW MORE OPPORTUNITIES WITH DoD<https://orise.orau.gov/dodprograms/current-research-opportunities.html> [Facebook]<https://www.facebook.com/ExperienceORISE/> [Twitter]<https://twitter.com/experienceorise> [Instagram]<https://www.instagram.com/experienceorise> [LinkedIn]<https://www.linkedin.com/showcase/experienceorise> [Website]<https://orise.orau.gov/dodprograms/> --- If you received this mailing from a colleague and would like to receive future mailings directly in your inbox then please send a blank email to: subscribe-dodinternships(a)listserv.orau.org<mailto:subscribe-dodinternships@listserv.orau.org> ? ? You received this e-mail due to your institutional or organizational affiliation. If we sent this e-mail to you in error, and you wish not to receive any further e-mails from us, please send a blank email to leave-94846-2862850.884bf76079cfa0dcee4c6597339ce304(a)listserv.orau.org<mailto:leave-94846-2862850.884bf76079cfa0dcee4c6597339ce304@listserv.orau.org>

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NEW Research Opportunities with DoD
by Siemers, Tammy R 30 Jun '22

30 Jun '22

[https://mcusercontent.com/d362006591b8be72fcbd58ffc/images/3a079f84-b6de-4d…] The Oak Ridge Institute for Science and Education (ORISE) is accepting applications for paid internship and fellowship opportunities<https://orise.orau.gov/dodprograms/current-research-opportunities.html> at the U.S. Department of Defense (DoD). Apply now! Scientific Review and Oversight of Biomedical Research Fellowship at WRAIR <https://zintellect.com/Opportunity/Details/MRMC-WRAIR-2022-0004> Location: Silver Spring, MD Degree: Master's Degree received within the last 60 months Citizenship: U.S. Citizen or LPR Postdoctoral Fellowship in Human-Computer Interaction Research For Cyberspace Modeling and Simulation Training at DEVCOM-SC <https://zintellect.com/Opportunity/Details/DEVCOM-SC-2022-0004-R> Location: West Point, NY Degree: Doctoral Degree received within the last 60 months Citizenship: U.S. Citizen Food Science Research at U.S. Army DEVCOM - Soldier Center <https://zintellect.com/Opportunity/Details/DEVCOM-SC-2022-0008> Location: Natick, MA Degree: Bachelor's Degree, Master's Degree, or Doctoral Degree received within the last 60 months or anticipated to be received by 9/1/2022 Citizenship: U.S. Citizen ORISE Research Fellow Nutritional Sciences and Exercise Physiology <https://zintellect.com/Opportunity/Details/USAMRMC-RIEM-2022-0023> Location: Natick, MA Degree: Bachelor's Degree or Master's Degree received within the last 60 months or anticipated to be received by 8/31/2022 Citizenship: U.S. Citizen Faculty Research Fellowship in Applied Analysis of Human Behavior<https://zintellect.com/Opportunity/Details/NGA-2022-0004F> Location: Remote Degree: Doctoral Degree and be a current full-time faculty member at an accredited institution of higher education Citizenship: U.S. Citizen U.S. Army Environmental Command (USAEC) Natural Resources Program Freshwater Fisheries Fellowship <https://zintellect.com/Opportunity/Details/Army-AEC-2022-0004> Location: West Point, NY Degree: Bachelor's Degree, Master's Degree, or Doctoral Degree received within the last 60 months or currently pursuing Citizenship: U.S. Citizen U.S. Army Environmental Command (USAEC) Knowledge Management Intern <https://zintellect.com/Opportunity/Details/Army-AEC-2022-0005> Location: Joint Base San Antonio - Fort Sam Houston, Texas Degree: Bachelor's Degree or Master's Degree received within the last 60 months or currently pursuing Citizenship: U.S. Citizen Mechanical Engineer - Hyperbaric Research <https://zintellect.com/Opportunity/Details/NEDU-2022-0003> Location: Panama City, FL Degree: Bachelor's Degree or Master's Degree received within the last 60 months or currently pursuing Citizenship: U.S. Citizen VIEW MORE OPPORTUNITIES WITH DoD<https://orise.orau.gov/dodprograms/current-research-opportunities.html> [Facebook]<https://www.facebook.com/ExperienceORISE/> [Twitter]<https://twitter.com/experienceorise> [Instagram]<https://www.instagram.com/experienceorise> [LinkedIn]<https://www.linkedin.com/showcase/experienceorise> [Website]<https://orise.orau.gov/dodprograms/> --- If you received this mailing from a colleague and would like to receive future mailings directly in your inbox then please send a blank email to: subscribe-dodinternships(a)listserv.orau.org<mailto:subscribe-dodinternships@listserv.orau.org> ? ? You received this e-mail due to your institutional or organizational affiliation. If we sent this e-mail to you in error, and you wish not to receive any further e-mails from us, please send a blank email to leave-94829-2862850.884bf76079cfa0dcee4c6597339ce304(a)listserv.orau.org<mailto:leave-94829-2862850.884bf76079cfa0dcee4c6597339ce304@listserv.orau.org>

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BME Master's Defense Announcement for John R. Anderson (L. Solorio and M. Wendt, co-advisors)
by May, Sandra M 29 Jun '22

29 Jun '22

BME Master's Defense Announcement for John R. Anderson (L. Solorio and M. Wendt, co-advisors) Everyone is invited to attend the public presentation beginning at 8:00 AM EST. Thesis Title: "Downregulation of FGFBP1 During Epithelial to Mesenchymal Transition" Date: July 13, 2022 Time: 8:00 AM EST Location: Zoom* Topic: John Anderson's Masters Defense Time: Jul 13, 2022 08:00 AM Eastern Time (US and Canada) Join Zoom Meeting https://purdue-edu.zoom.us/j/95017718388 Thesis Committee: Luis Solorio, Co-Chair; Michael K. Wendt, Co-Chair; Craig J. Goergen Abstract: Breast cancer is a disease that impacts nearly one out of three women at some point in their life. Although the scientific community's understanding of breast cancer development is actively researched, there is still a low 5-year survival rate of 30% following distant metastasis compared to the near 100% localized survival rate. Many factors in a tumor microenvironment drive tumors to metastasize. Epithelial to mesenchymal transition (EMT) is a known contributor to metastasis. Cells that undergo EMT shed cell-to-cell junctions and become fibroblastic like cells with differential extracellular matrix organization and increased mesenchymal gene expression. This change allows for greater cell motility and invasive potential, critical for metastasis. Our recent studies with single cell RNA sequencing demonstrate several distinct populations of epithelial and mesenchymal cells. Several components of fibroblast growth factor receptor (FGFR) signaling are regulated during EMT. Fibroblast growth factor binding protein 1 (FGFBP1) is a known developmental factor that was observed to have low expression in mesenchymal cells, with an unknown role in breast cancer. This study utilizes immunoblotting, mRNA analyses, immunofluorescence staining and novel 3D culture platform to investigate the regulation FGFBP1 during EMT. FGFBP1 was consistently downregulated in HER2 transformed human mammary epithelial cells (HME2) during transforming growth factor β (TGF-β) induced EMT. Since FGFBP1 is known to act as a secretory chaperone protein, secretion rate analysis was conducted at time periods throughout EMT showing rapid downregulation of secretion. Characterization of FGFBP1 regulation during EMT could lead to greater understanding of EMT. *additional Zoom info: Meeting ID: 950 1771 8388 One tap mobile +13017158592,,95017718388# US (Washington DC) +13126266799,,95017718388# US (Chicago) Dial by your location +1 301 715 8592 US (Washington DC) +1 312 626 6799 US (Chicago) +1 646 558 8656 US (New York) +1 646 931 3860 US +1 253 215 8782 US (Tacoma) +1 346 248 7799 US (Houston) +1 669 444 9171 US +1 669 900 6833 US (San Jose) Meeting ID: 950 1771 8388 Find your local number: https://purdue-edu.zoom.us/u/aewZ2rLalu

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BME Master's Defense Announcement for Ana K. Kirby (B. Duerstock, advisor)
by May, Sandra M 28 Jun '22

28 Jun '22

BME Master's Defense Announcement for Ana K. Kirby (B. Duerstock, advisor) Everyone is invited to attend the public presentation beginning at 2:00pm EST. Title: Frequency and Time Domain Analysis of Physiological Features during Autonomic Dysreflexia after Spinal Cord Injury Date: July 11, 2022 Time: 2:00pm EST Location: Zoom https://purdue-edu.zoom.us/j/94919821296 Meeting ID: 949 1982 1296 One tap mobile +13017158592,,94919821296# US (Washington DC) +13126266799,,94919821296# US (Chicago) Dial by your location +1 301 715 8592 US (Washington DC) +1 312 626 6799 US (Chicago) +1 646 558 8656 US (New York) +1 253 215 8782 US (Tacoma) +1 346 248 7799 US (Houston) +1 669 900 6833 US (San Jose) Meeting ID: 949 1982 1296 Find your local number: https://purdue-edu.zoom.us/u/aciR81uypl Advisory Committee: Bradley S. Duerstock, Chair; Riyi Shi; Thomas H. Everett IV Abstract: Persons with a spinal cord injury (SCI) often suffer from secondary complications including the dysfunction of the autonomic nervous system below the level of injury. For persons with a SCI at or above T6, autonomic dysreflexia (AD) may be triggered by noxious stimulation below the level of injury causing rapid sympathetic hyperactivation, leading to paroxysmal hypertension. If AD is not recognized and managed promptly, this increase in blood pressure can lead to stroke, organ damage, and/or death. Currently, AD is only determined in clinical settings through intermittent blood pressure monitoring. Recent studies have revealed that accurate detection of the onset of AD is possible by using extracted features from electrocardiogram (ECG) data collected non-invasively to develop a machine learning model with a five-layer neural network. This project further characterizes physiological responses before and during AD to noninvasively measure the overreaction of sympathetic nerve activity prior to the detrimental increase in hypertension. Animals were implanted with ECG telemetry to compare changes in blood pressure with high temporal resolution as the gold standard for determining AD. A four-week acclimation protocol was developed to minimize noise and motion artifacts during data collection from noninvasive ECG sensors in conscious rats. Only a minimal increase in sympathetic activity occurred prior to experimentation. We analyzed skin nerve activity (SKNA) and heart rate variability parameters in the time and frequency domain post-SCI to improve the non-invasive detection of AD. Results indicated an increase in SKNA features occurred 18.1 seconds before the initial rise in blood pressure after the onset of AD. Additionally, integrated SKNA features in the frequency domain quantified nerve activity and low frequency components were found to be dominant during AD, providing another parameter that can be used to improve the responsiveness and accuracy of machine learning models to detect AD. In humans, noninvasive SKNA monitoring may be used to alert persons with SCI of the onset of AD prior to critical increases in blood pressure, improving management techniques and potentially decreasing the severe effects of AD.

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[Bmeroundtable-list] BME Summer Seminar Announcement: June 29th 9:30-10:30am EST via Zoom
by Rowen, Elizabeth Pearl 27 Jun '22

27 Jun '22

[cid:image001.jpg@01D88A09.E8FC0980] BME Summer Seminar Series Wednesday, June 29th, 2022 9:30-10:30AM EST Via Zoom Meeting - link below* Evaluation links: Anna Alford: https://purdue.ca1.qualtrics.com/jfe/form/SV_3yYMKwlzjH9hBvE Brenna Vaughn: https://purdue.ca1.qualtrics.com/jfe/form/SV_3ltS5zv62XhPERo The Role of Acrolein for Influencing Disease Severity in EAE Mice Anna Alford (R. Shi, advisor) [cid:image004.jpg@01D88A09.E900C470] Abstract: Acrolein, a pro-inflammatory and pro-oxidative neurotoxin, has previously been demonstrated to contribute to demyelination and axonal injury, two key pathological hallmarks of multiple sclerosis (MS) in preclinical models. Acrolein scavengers such as hydralazine have therefore recently shown therapeutic promise in mitigating symptom severity in mice with experimental autoimmune encephalomyelitis (EAE), a widely utilized animal model of MS. However, the extent to which targeting acrolein can combat MS pathology has yet to be fully investigated. Our lab is the first to explore the effects of influencing both exogenous and endogenous mechanisms of regulating acrolein on EAE disease severity. To bolster the clinical relevance of acrolein scavenging as a therapeutic approach, we investigate the effects of pre-symptomatic and post-symptomatic applications and confirm the effectiveness of both in alleviating motor deficits and neuropathic pain in EAE mice. Additionally, we observe a strong correlation between levels of acrolein and myeloperoxidase, an established inflammatory marker, in response to acrolein scavenging treatments in EAE mice. Furthermore, we demonstrate heightened disease severity resulting from genetically weakening aldehyde dehydrogenase 2 (ALDH2), a means of endogenous acrolein scavenging, in a clinically relevant ALDH2*2 mouse variant. In contrast, pharmacologically enhancing ALDH2 using Alda-1 is capable of lowering acrolein and providing motor and sensory benefits to EAE mice. Current efforts are focused on utilizing the ALDH2*2 variant to further investigate the mechanisms by which acrolein contributes to enhanced disease severity in Multiple Sclerosis. Antibody-Drug Conjugate Resistance in HER2+ Breast Cancer Brenna Vaughn (M. Wendt/L. Solorio, advisor) [cid:image006.jpg@01D88A09.E900C470] Abstract: One in eight women will develop breast cancer in their lifetime. Approximately 20-25% of these cases overexpress human epidermal growth factor 2 (HER2), a receptor tyrosine kinase that defines an aggressive subtype of breast cancer. HER2-targeted therapies have been developed over the past two decades and have improved overall survival in HER2+ breast cancer patients. One of the more recently developed HER2-targeted therapies is T-DM1. T-DM1 is an antibodydrug conjugate comprised of a HER2-specific antibody, trastuzumab, conjugated to a cytotoxic agent, emtansine, by a stable linker. However, metastatic recurrence remains an immediate threat to survival as most patients with metastatic disease will develop resistance to such therapies. In fact, when the disease recurs as distant metastasis rather than local disease, the 5- year survival rate drops to only 25%. Significant gaps in knowledge remain in the understanding of how breast cancer cells gain resistance to HER2-targeted therapies and result in lifethreatening metastatic disease. Here, we investigate the potential involvement of a protein crosslinking enzyme, tissue transglutaminase 2 (TG2), as a driver of resistance to antibodybased therapies in HER2+ breast cancer. Preliminary results suggest that TG2 overexpression in HER2-transformed human mammary epithelial (HMLE) cells may be important in acquiring resistance to the HER2-targeted antibody-drug conjugate T-DM1. We hypothesize that TG2 overexpression may reduce the efficacy of T-DM1 through the occlusion of antibody binding sites or crosslinking free T-DM1. Current work has included the derivation of a TG2 overexpressing HER2-transformed HMLE strain using a lentiviral stable transduction approach, establishing an IC50 value for T-DM1 in these cells, and validation of TG2 overexpression by western blot. Planned studies include imaging of trastuzumab penetration into tumors through organ-clearing techniques as well as time until recurrence of disease studies with T-DM1 resistant HER2+ cells. Successful completion of this work will aid in identifying strategies to overcome resistance to HER2-targeted therapies. *Join Zoom Meeting https://purdue-edu.zoom.us/j/92168739019?pwd=cnBOaFBxN3FWVVVTWC8wWWhaekdIdz… Meeting ID: 921 6873 9019 Passcode: biomedical Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] ALERT: MJIS Freight elevator
by Gelfand, Johanna K 24 Jun '22

24 Jun '22

Good Morning. THE FREIGHT ELEVATOR WILLL BE DOWN THIS MORINING TO REPAIR THE FLOOR. We hope to be back up around 10:30-11:00 You may use the passenger elevator temporarily to transport research materials. Please remember to alert any passengers who may need to use the elevator that you are transporting research materials so that they may wait until you have unloaded to enter the elevator. Thank you Susan -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Weldon Graduate Program Announcements June 22nd, 2022
by Siemers, Tammy R 22 Jun '22

22 Jun '22

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements June 22nd, 2022 * Career and Internship Opportunities * Midwest Abbott Hires-- Electrophysiology Clinical Specialist * New Sandia Bioscience PostDoc Fellowship * SAi Fellows Program still Accepting Applications! * Job Opportunities for International Students * OITE events (resilience, med school, networking, science) this week * Graduate Professional Development Newsletter (June 17) * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Summer 2022 Associate Engineer, SpaceX<https://www.linkedin.com/jobs/view/3046559089/?lgTemp=jobs_jymbii_digest&eB…> Postdoctoral Positions * Postdoctoral Research Associate, University of Wisconsin Madison<https://www.simplyhired.com/job/zlBJIlchEL2i2fQftbyLU-mBgQmSgEWiGQ5WICvhHTF…> * Postdoctoral Scholar, Biomolecular Engineering/Biological Nanotechnology, University of Washington<https://ap.washington.edu/ahr/position-details/?job_id=97143> * Postdoctoral Fellowship, Genetic Engineering, FAMU-FSU<https://www.simplyhired.com/job/kRr_VfJtw2Lq6jzZtg66H9BtZ89xOT2b8xHZJEMI6lv…> * NPA Website: https://careers.nationalpostdoc.org/jobs/ Full time Positions * Biomedical Engineering Associate, Exponent<https://phe.tbe.taleo.net/phe03/ats/careers/v2/viewRequisition?org=EXPONENT…> * Biomedical Engineer, AtriCure<https://globalus62e2.dayforcehcm.com/CandidatePortal/en-US/atricure/Posting…> * R&D Engineer II, Boston Scientific<https://jobs.bostonscientific.com/job/Marlborough-MA-01752/897455000/?jobPi…> * Clinical Engineer, Invoy<https://www.simplyhired.com/job/50O744lFyBalJyVu-b0RUp1bfbyWiqvmoGTaMLUDcHG…> * QA Engineer III, ThermoFisher Scientific<https://jobs.thermofisher.com/global/en/job/204526BR/QA-Engineer-III?rx_cam…> * Advisory Human Factors Engineer, Contract, Zoll<https://zoll.wd5.myworkdayjobs.com/en-US/ZOLLMedicalCorp/job/US-PA-Pittsbur…> * Senior Research Technologist, Physiology & Biomedical Engineering, Mayo Clinic<https://jobs.mayoclinic.org/job/-/-/33647/30641859776> * Computational Biologist, CFD Research Corporation<https://www.simplyhired.com/job/zQsFPUBaPXXYmJpz9lli7MW7lnPy0d3gcXTHihPi854…> * R&D Engineer, Candor Solutions<https://www.simplyhired.com/job/K2CM9ODh5yUL9p0907JyIxQt29RbofuyMOXRA5tMH3q…> * Electrical Engineer, Ultrasound, DeepSight Technology<https://www.simplyhired.com/job/P-o8Gf3Lnh_KAcqUQLXKOEMo63diGuZEnR0kdPoox6k…> * Purdue Start-up Job Board<https://purduefoundry.com/jobs?utm_source=Foundry+Mailing+List&utm_campaign…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://careers.actscience.org/>-Association for Clinical and Translational Science * Doc Jobs<https://www.docjobs.com/jobs/list/>-Jobs beyond traditional clinical and academic roles Midwest Abbott Hires-- Electrophysiology Clinical Specialist We're now actively hiring for both Ft Wayne, IN and Ann Arbor, MI. Take a look below for a more detailed description of the role as well as some product references for any candidate to check out. The link to the product pages as well as checking out the listed hashtags on Twitter will shed a really nice light on what they will be creating in this role. Job Title: Electrophysiology Clinical Specialist Job Description: In this role, you will assist with the implantation and support of cardiac mapping procedures. Assists in the day-to-day management of various clinically-related issues. Working under direct supervision, provides educational and technical support in response to field inquiries from physicians, health care professionals, patients, and field sales staff. Identifies and routinely uses the most effective, cost efficient and best business practices to execute processes; continually evaluates their effectiveness and appropriateness. Exercises judgment in planning, organizing and performing work; monitors performance and reports status to manager. Engages in activities and behaviors to become proficient in the servicing of accounts. As appropriate, may assist marketing personnel in the support of advertising and promotional sales activities. The main product is a cardiac mapping system called Ensite X. Here is a link to it for more info: https://www.cardiovascular.abbott/us/en/hcp/products/electrophysiology/mapp… There is a pretty active Twitter community that showcases case images as well. It be helpful to look up the following hashtags: #HDGrid #EnsiteX #OnlywithOT #OneBurnTerm New Sandia Bioscience PostDoc Fellowship Deadline: July 29 https://www.sandia.gov/careers/career-possibilities/students-and-postdocs/f… SAi Fellows Program still Accepting Applications! https://stemadvocacy.org/sai-fellows/ Do you have an idea for a science outreach or public engagement project? Are you looking for funding, mentorship, and a community to support your idea? Consider applying to the SAi Fellows Program which will provide you the theory, design, implementation, and evaluation knowledge-base to enable you to build a fundable and sustainable informal science engagement initiative. The deadline to apply is June 30, 2022. The program is completely virtual and will run between mid Sept - early Nov. Graduate students and postdocs can apply. You can learn more about the program and apply online here: https://stemadvocacy.org/sai-fellows/ Contact the program directly via email (programs(a)stemadvocacy.org<mailto:programs@stemadvocacy.org>) if you have any questions. Job Opportunities for International Students https://cturtle.co/jobs-for-international-students-graduates-alumni/ OITE events (resilience, med school, networking, science) this week Hello from the OITE. We have a terrific week, and hope you can join us. Friday we are hosting the Acting NIH Director, Dr. Larry Tabak, to talk about his science and more! * Networking, Informational Interview, and Using LinkedIn for Career Advancement<https://www.training.nih.gov/events/view/_2/6534/Networking_Informational_I…> Thursday Jun 23, 2022 1:00 pm - 2:00 pm * Summer Lecture Series I - A Conversation with Dr. Larry Tabak<https://www.training.nih.gov/events/view/_2/6557/Summer_Lecture_Series_I_Dr…> Friday Jun 24, 2022 2:00 pm - 3:00 pm OITE Blog: * Taming Your Inner Critic - Part I<https://oitecareersblog.od.nih.gov/2022/06/20/taming-your-inner-critic-part…> * Finding the 'back door' for jobs<https://oitecareersblog.od.nih.gov/2022/06/13/finding-the-back-door-for-job…> * The Link Between Narcissism and Work Promotions<https://oitecareersblog.od.nih.gov/2022/06/06/the-link-between-narcissism-a…> * Searching for Jobs in the United States as an International Applicant<https://oitecareersblog.od.nih.gov/2022/05/23/searching-for-jobs-in-the-uni…> * Create a LAMP List to Help Target Key Companies of Interest<https://oitecareersblog.od.nih.gov/2022/05/16/create-a-lamp-list-to-help-ta…> OITE YouTube Channel<https://gcc02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtu…> * Jobs with the Federal Government<https://gcc02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtu…> * Career Symposium: Careers in Industry<https://gcc02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtu…> * Career Symposium: Careers in Academics (faculty and non-faculty)<https://gcc02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtu…> * Career Symposium: Careers for the love of science<https://gcc02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtu…> * Career Symposium: Hiring trends 2022<https://gcc02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtu…> * Career Symposium: Why career planning is so hard; and how we can make it easier<https://gcc02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.youtu…> Graduate Professional Development Newsletter (June 17) LINK: Graduate Professional Development Newsletter (June 17)<https://mailimages.purdue.edu/vo/?FileID=f96ac6df-61e5-4946-8078-8a4226f7e8…> Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. June 22nd BME and IBSc Summer Seminar Presentation: Conner Earl & Kentaro Umemori June 22nd Business Meal Etiquette (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> June 23rd Purdue Postdoc Alumni Panel: Careers, Experiences, and Transferable Skills Part 2 (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> June 24th Bench to BARDA (Virtual) June 28th RCR: Discipline-Specific Training (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> June 28th 2022 Crane IP Pitch Competition June 28th Bench to BARDA (Virtual) June 29th BME and IBSc Summer Seminar Presentation: Anna Alford & Brenna Vaughn June 29th Suicide Prevention Training June 30th Building Mentoring Relationships (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> July 1st Bench to BARDA (Virtual) July 6th BME and IBSc Summer Seminar Presentation: Agnes Doszpoly & Zachary Davis July 6th Deadline to apply for James Dyson Award July 13th BME and IBSc Summer Seminar Presentation: Claudia Benito Alston & Lexi Petrucciani July 18th Coffee with the Dean (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> July 19th Citation Management with Zotero (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> July 19th RCR: Discipline-Specific Training (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> July 19th Suicide Prevention Training July 20th BME and IBSc Summer Seminar Presentation: Om Kolhe & Julia Walsh July 20th Business Meal Etiquette (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> July 27th BME and IBSc Summer Seminar Presentation: Seokkyoon Hong & Sang Hoon Um July 27th Postdoc Grant Writing Lecture: All about National Science Foundation Grants (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> July 27th How to Find and Prepare for Fellowship Applications (Grad) (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> August 3rd BME and IBSc Summer Seminar Presentation: Donghyun Yim & Seul Ah Lee August 10th BME and IBSc Summer Seminar Presentation: Lucy Tecle & Luke Brennan August 17th RCR: Discipline-Specific Training (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers Senior Graduate Training Program Administration and Professional Development Specialist Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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Future Faculty Recruitment Opportunity
by Siemers, Tammy R 20 Jun '22

20 Jun '22

Ahmedabad University: Recruitment for Future Faculty 06/22/2022 10:00 A.M. - 12:00 P.M. EST Professor Pankaj Chandra, the Vice Chancellor of Ahmedabad University in India will give a presentation on the faculty positions that are available and the research at Ahmedabad University to recruit PhD students and postdocs. After his presentation. Prof. Chandra will answer questions from the audience and provide opportunities to meet individuals who are interested in applying for the faculty roles. *Open faculty positions are available for engineering, sciences, humanities & social sciences, management, environment, public health* This event is organized by the Office of Global Partnerships. Event Registration Link: https://gspd.gosignmeup.com/public/Course/browse?courseid=3764&AllowDirectL…

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[Bmeroundtable-list] BME Summer Seminar Announcement: June 22nd 9:30-10:30am EST via Zoom
by Rowen, Elizabeth Pearl 20 Jun '22

20 Jun '22

[cid:image001.jpg@01D8826A.BE10DCB0] BME Summer Seminar Series Wednesday, June 22nd, 2022 9:30-10:30AM EST Via Zoom Meeting - link below* Evaluation links: Conner Earl: https://purdue.ca1.qualtrics.com/jfe/form/SV_2rB2a4kk4z5wrnU Kentaro Umemori: https://purdue.ca1.qualtrics.com/jfe/form/SV_5yWw7t7bBmjdhgW Strain Characterization of Cardiac Pathology Using 4D Imaging Conner Earl (C. Goergen, advisor) [cid:image006.jpg@01D8847F.D84BF800] Abstract: Heart disease is the leading cause of death worldwide- contributing to nearly 1 in 4 deaths in the United States. 4D (3D+time) cardiac imaging is a promising imaging technique that allows for the comprehensive assessment of heart biomechanics- specifically myocardial strain. This assessment allows for better characterization of cardiac disease models in preclinical research and better diagnosis and treatment for heart disease patients in the clinic. Additionally, automated techniques that utilize deep convolutional neural networks (CNNs) provide a unique opportunity to leverage the value of 4D imaging while streamlining analysis and processing. In this presentation, I will describe how we use 4D cardiac imaging to assess both preclinical mouse models of heart disease and how we can use similar techniques to characterize pediatric heart disease. Finally, we will discuss the growing role of machine and deep learning techniques that allow for rapid and accurate automated image analysis making these techniques more user friendly and accessible to the clinic and other researchers. Three-Dimensional Meltblowing as a High Speed Fabrication Process for Tendon Engineering Scaffolds. Kentaro Umemori (D. Little, advisor) [https://engineering.purdue.edu/ResourceDB/ResourceFiles/image243527/alter?h…] Abstract: Over 250,000 rotator cuff tendon tears are repaired annually in the US, but even after surgery, the retear rate is up to 90% for massive tears due to the formation of structurally and mechanically inferior fibrotic scar tissue during healing. To augment the repair process, tendon tissue engineering (TTE) approaches seek to improve these outcomes using biomimetic scaffolds. The scaffold fabrication process, standard meltblowing (SMB), has gained interest in TTE by being high-throughput and economical while accurately producing fiber diameters matching the native tendon microstructure. However, SMB produces non-aligned fiber mats with limited tunability in the three-dimensional (3D) architecture. This led to the development of 3D meltblowing (3DMB) which introduces a robotic collector that can produce scaffolds at high speeds with highly organized fibers and at anatomically relevant dimensions. However, the performance of 3DMB scaffolds for TTE applications is unknown. A technique to evaluate scaffolds for TTE is by seeding cells and assessing the cell behavior. Thus, I hypothesize that 3DMB scaffolds seeded with human adipose derived stem cells (hASCs) will induce the formation of tendon-like extracellular matrix. In this study, we used 3DMB scaffolds fabricated using poly-L-lactic acid (PLA) and poly-ε-caprolactone (PCL) and assessed its fiber parameters, observed its impact on cell behavior, and compared the results with PLA SMB scaffolds. Fiber analysis of 3DMB scaffolds demonstrated closer resemblance to tendon microstructure than standard meltblown scaffolds by exhibiting greater alignment and mechanical anisotropy. 3DMB scaffolds after 28 days of culture demonstrated cell proliferation and deposition of aligned tendon-like extracellular matrix, but at lower levels compared to PLA SMB scaffolds. Furthermore, we discovered that cell culture has enhanced mechanical properties of 3DMB scaffolds. These results show that 3DMB is a promising method to fabricate scaffolds for TTE applications, however, further exploration is needed to elucidate their impact on cell behavior. *Join Zoom Meeting https://purdue-edu.zoom.us/j/92168739019?pwd=cnBOaFBxN3FWVVVTWC8wWWhaekdIdz… Meeting ID: 921 6873 9019 Passcode: biomedical Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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IBSC PhD Defense Announcement for Chenwei Duan (P. Sivasankar and C. Goergen, co-chairs)
by May, Sandra M 17 Jun '22

17 Jun '22

IBSC PhD Defense Announcement for Chenwei Duan (P. Sivasankar and C. Goergen, co-chairs) Everyone is invited to attend the public presentation beginning at 2:00pm EST. Title: The effects of hydration status on vocal fold pathobiology, biomechanics, and hemodynamics Date: June 30, 2022 Time: 2:00pm EST Location: Zoom* https://purdue-edu.zoom.us/j/91096633076 Meeting ID: 910 9663 3076 Committee: Preeti Sivasankar, Co-Chair; Craig J. Goergen, Co-Chair; Abigail D. Cox; Sarah Calve Abstract: Vocal fold vibration results in voice production. Optimal hydration levels contribute to self-sustained vocal fold vibration and preservation of voice quality. Adequate hydration is implicated as a factor in maintaining voice and preventing voice problems. Voice problems affect up to one third of adults during their lifetime. But whether altered hydration state adversely affects vocal fold biology and biomechanics is still unclear. To untangle the effects of systemic dehydration on vocal fold biology, we developed a water restriction protocol on lab animals that can translate to humans. Our results showed that dehydration induced by restricted water access downregulated the gene expression of IL-1α and desmoglein-1, upregulated the gene expression level of hyaluronidase-2, and downregulated hyaluronic acid (HA). Clinically, hydration treatments are hypothesized to maintain the viscoelastic properties of vocal folds. However, our understanding of the relationship between vocal fold tissue hydration level and biomechanical properties is still evolving. To investigate the effects of dehydration on biomechanical properties we used an ex vivo experimental design. We hypothesized that the optimal stiffness of vocal folds would be impacted after dehydration via losing both water and HA, but that the stiffness properties would recover through rehydration. To test this hypothesis, we experimentally treated porcine vocal fold samples using two different approaches: 1) immersion in hypertonic solution (15% NaCl in ddH2O) and PBS sequentially to mimic dehydration and rehydration, and 2) incubation with hyaluronidase (Hyal) to mimic HA loss during dehydration. Our results showed that loss of water increased tissue stiffness and could be recovered through rehydration in a certain degree. In addition, loss of HA increased tissue stiffness. While dehydration decreases total body blood volume, different tissues and organs of the body may be impacted in different ways from dehydration. Therefore, it is important to investigate the hemodynamic alterations during changes to hydration status.. Magnetic resonance angiography (MRA) and ultrasound imaging were employed to identify the delicate vascular geometry and hemodynamics of the laryngeal blood supply. Animals underwent both MRA and ultrasound imaging at baseline, dehydration and rehydration time points. Our results showed that dehydration impacted the blood supply to larynx. This blood supply was restored through rehydration treatment. Overall, this research has been successful in establishing a mild dehydration animal model, providing evidence from gene and protein levels that dehydration affects cytokine production and extracellular matrix components (ECM) in vocal fold, demonstrating the vocal fold tissue biomechanical behavior after dehydration and loss of HA, and offering a combination application of MRA and ultrasound imaging to study vascular geometry and hemodynamics of the blood supply to the vocal fold region. *Chenwei Duan is inviting you to a scheduled Zoom meeting. Topic: Chenwei's Defense Link Time: Jun 30, 2022 02:00 PM Eastern Time (US and Canada) Join Zoom Meeting https://purdue-edu.zoom.us/j/91096633076 Meeting ID: 910 9663 3076 One tap mobile +13126266799,,91096633076# US (Chicago) +16465588656,,91096633076# US (New York) Dial by your location +1 312 626 6799 US (Chicago) +1 646 558 8656 US (New York) +1 301 715 8592 US (Washington DC) +1 346 248 7799 US (Houston) +1 669 900 6833 US (San Jose) +1 253 215 8782 US (Tacoma) Meeting ID: 910 9663 3076 Find your local number: https://purdue-edu.zoom.us/u/aPaOkbDVF

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