October 2024 - Bmegradstudents-list

[Bmeroundtable-list] BMES 2024 photo immediately following the Plenary (~12:15)
by Kevin John Otto 24 Oct '24

24 Oct '24

For all #BMES2024 attendees, please remember to come to the BMES letters for the Weldon BME photo. The photo will be taken immediately following the Plenary session (~12:15). ____________________________________________________ Please join all of the Weldon School attendees in taking a group picture at 12:15 on Thursday in front of the BMES letters. The 3’ tall letters are intended for photo ops and are typically toward the entrance of the exhibit hall. You’ll likely pass them on your way to registration or into the hall. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME Distinguished Research Seminar - Wed., October 30
by Gelfand, Johanna K 23 Oct '24

23 Oct '24

[A screen shot of a message Description automatically generated] BME DISTINGUISHED RESEARCH SEMINAR SERIES Wednesday, October 30, 2024 9:30 - 10:20 am, MJIS 1001 ZOOM LINK: https://purdue-edu.zoom.us/j/95419101730<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> *Note: Students enrolled in the seminar course are expected to attend in person. "Water-Triggered Polymerization of a-Lipoic Acid for Surgical Adhesion" [Professor Phillip Messersmith Co-Authors Paper on Drug-Induced Tissue Regeneration - Materials Science & Engineering] Phillip Messersmith Professor & Chair of Bioengineering Class of 1941 WWII Memorial Chair in Bioengineering and Materials Science and Engineering University of California, Berkeley Abstract: Polymer adhesives play an important role in many medical, consumer and industrial products. Polymers of *-lipoic acid (aLA) have the potential to fulfill the need for versatile and environmentally friendly adhesives, but their performance is plagued by spontaneous depolymerization. In this talk, I will describe a facile method for rapid catalyst-free *LA polymerization induced by contact with water. Application of the monomer to a wet tissue surface afforded rapid solidification of a strong and elastomeric polymer adhesive that is resistant to spontaneous depolymerization. Fetal anomalies are increasingly being addressed with surgical interventions performed in the second or third trimester. Because the fetal membranes that enclose the womb are mechanically fragile and nonhealing, the defect created by the intervention increases the likelihood of preterm premature rupture of the membranes (PPROM), which is associated with increased risk of fetal morbidity and mortality. Adhesive biomaterials are being explored to seal fetal membrane defects, providing mechanical stability to the membranes, reducing amniotic fluid loss, and extending gestation. I will describe our efforts to use our new surgical adhesive to seal fetal membrane defects; preclinical experiments with our aLA surgical glue increased fetal survival from 0% to 100%. Biography: Phillip Messersmith is a Professor of Bioengineering and Materials Science and Engineering at UC Berkeley, where he is currently chair of the Department of Bioengineering. He earned his BS and PhD degrees from the University of Illinois at Urbana. After a postdoctoral fellowship at Cornell University, he was a faculty member at University of Illinois at Chicago and Northwestern University. Dr. Messersmith has published over 220 papers. Dr. Messersmith is a fellow of the Royal Society of Chemistry, the Materials Research Society and the American Institute for Medical and Biological Engineering. His awards and honors include a MERIT award from the National Institutes of Health, the Langmuir Lecture Award from the American Chemical Society, and the Clemson Award for Basic Research from the Society for Biomaterials. His academic research is focused on bioinspired materials, biointerfacial phenomena, and regenerative medicine. He has 47 US patents awarded and is a cofounder of three startups. ~ BME Host: Taimoor H. Qazi ~ -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Seminar lunch for grad students
by Siemers, Tammy R 23 Oct '24

23 Oct '24

Dr. Kinzer-Ursem and I are hosting Kristen Naegle<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fengineeri…> for the BME department seminar on Wed Nov 6th. If you are interested in having lunch with her, please email us and let us know. Thanks! Elsje Elsje Pienaar, PhD She/Her/Hers Associate Professor Director of Undergraduate Programs Weldon School of Biomedical Engineering Purdue University

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BME GSA Public Health Day
by Siemers, Tammy R 22 Oct '24

22 Oct '24

Hi All, On Friday, October 25th BME GSA will be hosting a public health day and flu shot clinic for our students. The current itinerary is: * 10:00 AM MJIS 1001, Talk by Dr. Rodriguez: Bridging BME and Public Health: Human-centered Design of a Rapid HPV Test for Cervical Cancer Screening * 11:00 AM to 1:30 PM MJIS 2001, Flu Shot Clinic, Reserve your spot here: https://bme-fluclinic.intend.io/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbme-flucl…> * 11:00 AM to 1:30 PM Commons outside MJIS 2001 swag and raffle giveaway! Stop by and see us even if you aren't getting vaccinated today! Best, Julia Walsh Graduate Student, Biomedical Engineering Purdue University

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[Bmeroundtable-list] BME Master's Defense Announcement for Diya Sakhrani (C. Goergen, advisor)
by May, Sandra M 21 Oct '24

21 Oct '24

BME Master's Defense Announcement for Diya Sakhrani (C. Goergen, advisor) Everyone is invited to attend the public presentation beginning at 1:30pm. Title: High-Frequency Ultrasound of Intervertebral Disc Strain and Microrobot Drug Delivery Systems Date: November 11, 2024 Time: 1:30pm Location: MRGN 121 Zoom: https://purdue-edu.zoom.us/j/7616725892<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…>, Meeting ID: 761 672 5892 Committee: Dr. Craig Georgen (Chair), Dr. Luis Solorio, Dr. David Cappelleri Abstract: High-frequency ultrasound is an excellent non-invasive imaging technique that we utilized in both the quantification of intervertebral disc strain and microrobots for targeted drug delivery systems due to its ability to provide real-time, high-resolution images of soft tissues without the need for invasive procedures. In the intervertebral disc study, it allows us to capture detailed strain measurements across time during dynamic loading, offering insights into tissue deformation under physiological conditions. Similarly, in the microrobot study, high-frequency ultrasound enables precise visualization and tracking of the microrobots within the tissue environment, ensuring accurate navigation and monitoring during targeted drug delivery. Understanding the mechanics of intervertebral disc injury and validating computational models requires accurate measurement of internal disc strain. While noninvasive imaging and advanced image processing have enabled strain quantification, these methods often depend on visual markers that may alter tissue behavior. Furthermore, they are typically limited to static testing, which does not fully capture physiological loading conditions. This study aims to utilize high-frequency ultrasound combined with texture correlation techniques to quantify strain within intervertebral discs during dynamic axial loading. This study demonstrates that high-frequency ultrasound is an effective tool for measuring disc strain under dynamic loading conditions. Inflammatory bowel disease (IBD) refers to a group of disorders characterized by chronic inflammation of the digestive tract. Common treatments for IBD, such as oral and injectable medications, are selected based on disease severity but present significant challenges. These include systemic toxicity, non-specific drug targeting, and degradation of the therapeutic agents in the upper gastrointestinal tract, which reduces treatment effectiveness before reaching the colon. The goal of this research is to develop and test microrobots for targeted drug delivery to inflamed regions of the colon in IBD patients. The microrobots are guided by external magnetic torque and aim to overcome the limitations of traditional IBD treatments by delivering smaller, more effective drug payloads directly to the site of inflammation. The study demonstrates that microrobots, guided by magnetic torque, can effectively deliver targeted drug payloads to inflamed regions of the colon. This method allows for a smaller drug payload compared to traditional treatments, offering a more precise and efficient approach for treating IBD. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME 3rd year PhD Seminar Series: Friday 10-25
by Rowen, Elizabeth Pearl 21 Oct '24

21 Oct '24

[cid:image001.jpg@01DB05C3.B4BD0650] BME 3rd Year Seminar Series Friday, October 25th, 2024 1:30 - 2:30 PM EST MJIS 1001 Evaluation links: Laura Nunez Alvarez: https://purdue.ca1.qualtrics.com/jfe/form/SV_38aeZ2NTMmCejH0<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Elizabeth Frazier: https://purdue.ca1.qualtrics.com/jfe/form/SV_5toy71VUvqTEs18<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Evaluation surveys should only be completed after the seminar has taken place, and only by those who attended the seminar. A Multiscale Approach to Understanding Tissue Expansion-Induced Changes in Skin Mechanics and Cellular Behavior Laura Nunez Alvarez (Adrian Buganza Tepole, advisor) [cid:image002.jpg@01DB23AB.7B8D9E20] Abstract: Breast cancer is the most diagnosed cancer in women in the US. Approximately 50% of patients opt for or are advised to undergo a mastectomy. After removal, patients can undergo Breast Reconstruction Surgery (BRS), mostly done with Tissue Expansion (TE). TE complications include necrosis, excessive asymmetry, and capsular contraction, as TE is alternated with Radiotherapy (RT). Unfortunately, little is known about the cellular processes that drive those changes and the combined effect of TE and RT on skin tissue and cells. The present study aims to quantify tissue changes, such as skin stiffness, through biaxial testing, collagen architecture changes through histology analysis, and cellular changes through protein quantification. Collected and reported data will feed a TE multiscale model to predict growth and inform BRS protocols. We will use a porcine model with applied TE and RT for mechanical testing and histology analysis. From this model, we will quantify the cellular expression of mechanoresponsive proteins such as YAP and TE-induced area growth. Moreover, we will create a 3D culture that mimics the cell environment under TE and RT to translate our results to the human case. This 3D model will have dermis-like fibrillar hydrogels and human skin cells. We will quantify protein expression, growth, and mechanical properties, as done in the animal model. We expect the nuclear YAP activation, collagen production, and proliferative activity to increase with stretching time. We also expect the hydrogel stiffness to correlate with fiber network changes. We will describe the multiscale TE dynamics with a cell signaling model linked to a tissue physical model. This study will provide a multiscale characterization of the skin tissue and cellular activity when they undergo TE. Our results will help elucidate critical factors in the BRS process that will help design better protocols to diminish adverse effects. Emergence of integrated visual motion responses across the cortical hierarchy Elizabeth Frazier (Maria Dadarlat Makin/Anne Sereno, advisors) [cid:image006.jpg@01DB23AB.7B8D9E20] Abstract: The perception of visual motion is fundamental for navigating and interacting with our surroundings. In the brain, visual motion is first detected locally by neurons in the primary visual cortex (V1), whose responses are limited to small, discrete regions of the visual field. To recognize coherent motion of larger visual scenes, like a flock of birds or the flow direction of a river, higher visual areas must integrate the spatially distinct local motion signals from V1 (e.g., movement of a single bird) into a unified global motion percept. While specific cortical regions are known to specialize in this process, it remains unclear how integrated motion signals emerge throughout the cortical network. In this study, we investigated the emergence of motion sensitivity across the visual cortex of mice using two types of motion stimuli: drifting gratings (representing local motion) and random dot kinematograms (RDKs; representing global motion). We recorded mesoscale neural responses to these stimuli using in vivo two-photon calcium imaging in mice expressing GCaMP6s, a fluorescent indicator of neuronal activity. Our results showed a gradient of motion selectivity along the cortical hierarchy, with V1 robustly responding to grating stimuli and higher visual areas exhibiting enhanced tuning to the direction of the RDKs. This gradient was matched by an increase in neural response latencies, suggesting higher visual areas may perform spatiotemporal integration of local motion into a global motion signal. Furthermore, analyses of latent neural population dynamics revealed distinct encoding patterns for the two types of motion stimuli. These findings deepen our understanding of the functional role of mouse higher visual areas in visual motion processing. Ultimately, this work has important implications for expanding the utility of mouse models in studying the maladaptive changes in visual motion perception that characterize many neurological conditions. Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME Distinguished Research Seminar - Wed., Oct. 23
by Gelfand, Johanna K 18 Oct '24

18 Oct '24

[A close up of a sign Description automatically generated] BME DISTINGUISHED RESEARCH SEMINAR SERIES October 23, 2024 9:30-10:20 am, MJIS 1001 and via ZOOM ZOOM LINK: https://us02web.zoom.us/j/81438777812?pwd=VfUbYTUYnTdW3KDQ2JCAP08toFHE9A.1<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fus02web.z…> *Note: Students enrolled in the seminar course are expected to attend in person. "Bioelectromagnetic Brain Agents: New Routes for Tapping into the Nervous System Communication Grid" [Aviad Hai] Aviad Hai Assistant Professor Department of Biomedical Engineering Grainger Institute for Engineering & Department of Electrical and Computer Engineering University of Wisconsin-Madison Abstract: There is currently a concerted effort to develop technologies to record and stimulate neural activity across the entire volume of the mammalian brain. Recent engineering advancements have propelled electrode- and optical-based devices, achieving nanometer scale spatial resolution and impressive signal-to-noise ratio and temporal response. However, these probes usually require tethered connections and provide access to relatively small areas in the nervous system. Developing modalities to access the entire brain for direct recording and stimulation of neural signals, will allow neuroscientists and neurologists to study and treat the brain network directly and as a whole, and is expected to elevate brain science and medicine to new heights. I will describe the development of wireless, implantable electronic probes that are able to transduce electromagnetic fields in the brain, as well as the application of molecular agents for large volume in vivo measurements of neurotransmitter dynamics in live mammals. These strategies pave the way towards functional studies of neural activity across wide brain regions with molecular and electrophysiological specificity. Bio: Dr. Aviad Hai is a neuroengineer and a neuroscientist whose group focuses on developing implantable and injectable agents for accessing the nervous system-towards achieving a broader understanding of brain function. Dr. Hai is the recipient of the 2020 NIH Director's New Innovator award, the NIH NIBIB Mentored Research Scientist Development Award (K01), 2024 NSF EAGER award, a long-term fellowship from the European Molecular Biology Organization (EMBO) and a fellowship from the Edmond & Lily Safra Center for Brain Sciences. In 2019, Dr. Hai joined the Department of Biomedical Engineering at the University of Wisconsin-Madison as an assistant professor in 2019, where his group is developing cutting edge electrical, magnetic, and electromagnetic sensors for large-scale recording and stimulation of brain activity. Dr. Hai received his Ph.D. from the Hebrew University of Jerusalem under the guidance of Prof. Micha Spira (Neurobiology) and Prof. Joseph Shappir (Electrical Engineering), where he pioneered nano-scale devices for multiplexed recording of neuronal intracellular signals. He later joined Prof. Alan Jasanoff at the department of Biological Engineering at the Massachusetts Institute of Technology, where he developed wireless implantable sensors that detect electromagnetic fields in the brain, and molecular technologies for direct imaging of neurotransmitter dynamics across large volumes of the brain. His efforts cohere with the goal of providing neuroscientists and neurologists with a complete toolbox for understanding and modulating electrical and neurochemical activity across the entire volume of the brain in parallel. ~ BME Host: Krishna Jayant ~ Jo Gelfand Intra/Extramural Relations Administrator Purdue University Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 765-494-2996 jo(a)purdue.edu<mailto:jo@purdue.edu> [cid:image003.jpg@01DB2165.CD586F20] -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] 38x38 starting now
by Kevin John Otto 18 Oct '24

18 Oct '24

Please attend and bring your students. MJIS 1001. Get Outlook for Android<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Faka.ms%2F…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME PhD Preliminary Exam Announcement for Alexander Donabedian (D. Chan, advisor)
by May, Sandra M 17 Oct '24

17 Oct '24

BME PhD Preliminary Exam Announcement for Alexander Donabedian (D. Chan, advisor) Everyone is invited to attend the public presentation beginning at 2:00pm. Research Title: Subject-Specific Elastic, Fiber, and Swelling Spatial Variation in Finite Element Models of Articular Cartilage Informed by MRI Date, Time, Place: October 29, 2024 @ 2:00pm in MJIS 2001 Committee: Dr. Deva Chan (advisor), Dr. Chad Carroll, Dr. Vitaliy Rayz, Dr. Adrian Buganza Tepole Abstract: Osteoarthritis (OA) is a disabling joint disease that continues to prevail among the US population. Without a true noninvasive cure, total joint replacement surgery is a likely outcome which is costly for the healthcare system and individual. To shift treatment towards prevention and away from palliation, computational models can be a tool to study articular cartilage at risk of degradation, a hallmark sign of OA progression, before reaching severe states of the disease. Due to the complex microstructure of articular cartilage, generalized models cannot reliably provide subject-specific information regarding the health of the patient's tissue. Finite element models can be tailored to the patient with magnetic resonance imaging (MRI) improving their reliability. MRI-informed models exist today; however, very few of them address the spatially varying characteristics of articular cartilage hindering their accuracy. Here, we focus on using MRI to inform cartilage constituents primarily responsible for its tensile and compressive resistance in finite element models. Specifically, regional variations in stiffness, collagen fiber orientations, and osmotic swelling are informed by quantitative MRI techniques. Simulating the combined contribution of spatially varying properties is studied against models with generalized properties found in literature. Additionally, computed areas of high stress and strain are compared with longitudinal cartilage health data to assess the model's potential to predict regional degradation. By tailoring the simulated cartilage material properties and microstructure to the patient, the models can more reliably pinpoint areas at risk for degradation to potentially signal the onset of OA. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] REMINDER: Towing from the DLR lot starts in 45 minutes!
by Gelfand, Johanna K 17 Oct '24

17 Oct '24

From: Purdue University Parking <parking(a)purdue.edu> Sent: Thursday, October 17, 2024 1:57 PM To: Gelfand, Johanna K <jo(a)purdue.edu> Subject: Reminder: Plan ahead for event parking this Friday, Oct. 18 <https://maillinks.purdue.edu/t/46813999/1554839295/80194456/0/1003378/?72f7…> View as a Web page<https://maillinks.purdue.edu/t/46813999/1554839295/103000405/0/1003378/?b44…> [Purdue logo]<https://maillinks.purdue.edu/t/46813999/1554839295/63490351/0/1003378/?x=51…> NOTICE FROM PARKING FACILITIES Reminder: Plan ahead for event parking this Friday, Oct. 18 As a reminder, the campus community should plan ahead for parking later this afternoon and evening, and throughout the day tomorrow (Oct. 18), as game-day parking changes will be in force. The university recognizes the impact this has on faculty, staff and students and has added alternate parking locations with dedicated shuttle service to central campus so university activities can continue uninterrupted. Students, faculty, staff and visitors should review the parking information below before heading to campus for work or academic purposes. Thursday, Oct. 17 * Select parking lots will be unavailable beginning at 4 and 5 p.m. as noted on the Thursday map below. * Parking garages will operate normally with no pregame restrictions. [Parking map for Thursday, Oct. 17] Friday, Oct. 18 * All individuals with parking garage permits can park in their normal parking garage, will not need to move and will not be towed. Permit holders will be unable to enter the Northwestern Avenue and University Street Parking Garages beginning at 3 p.m. when event rates begin; however, they do not need to move if they are parked before 3 p.m. * While some lots near Ross-Ade Stadium<https://maillinks.purdue.edu/t/46813999/1554839295/102960773/0/1003378/?x=d…> will be closed for game-day parking per normal game-day operations (with clear signage), select lots located south of Stadium Avenue will be available until noon. These lots are highlighted on the Friday map below in dark gold. * All university parking south of Mitch Daniels Boulevard, except for Discovery Park lot, will be open with no ticketing or towing (except when public safety deems necessary). * To accommodate the closure of various parking lots, additional parking locations have been added with shuttle service available on Friday from 7 a.m.-7 p.m. The shuttle will run nonstop from Oval Drive at Memorial Mall to the locations noted in yellow on the Friday map below. Motorists should allow extra time to park and catch the shuttle. Parking attendants will be in place at each additional lot and will redirect motorists to open lots if lots become full throughout the day. * The Purdue Campus Connect shuttle<https://maillinks.purdue.edu/t/46813999/1554839295/101881422/0/1003378/?x=8…> will continue to run on Friday but will only be picking up and dropping off passengers at the Purdue Memorial Union and Stewart Center location. There will not be any stops at the France A. Córdova Recreational Sports Center on Friday. [Parking map for Friday, Oct. 18] Parking Facilities staff will be available by phone at 765-494-9497 until 8 p.m. today (Oct. 17). Normal parking staff availability resumes tomorrow (Oct. 18) from 7:30 a.m.-4:30 p.m. at 765-494-9497 or parking(a)purdue.edu<mailto:parking@purdue.edu>. The lobby, located in Stewart Center G054, closes at 4 p.m. Shop<https://maillinks.purdue.edu/t/46813999/1554839295/78175239/0/1003378/?x=73…> | Visit<https://maillinks.purdue.edu/t/46813999/1554839295/78217797/0/1003378/?x=e5…> | Give<https://maillinks.purdue.edu/t/46813999/1554839295/78217799/0/1003378/?x=6b…> Forward to a Friend<https://maillinks.purdue.edu/t/46813999/1554839295/103000363/0/1003378/?abb…> | Privacy Policy<https://maillinks.purdue.edu/t/46813999/1554839295/66794847/0/1003378/?x=b3…> This email was sent to: jo(a)purdue.edu<mailto:jo@purdue.edu> This email was sent by: Parking and Transportation 700 Ahlers Road West Lafayette, IN 47906 [https://mailimages.purdue.edu/purdueuniversity/PU_SIG_Logo_RGB__PU-H-Full-R…]<https://maillinks.purdue.edu/t/46813999/1554839295/71786932/0/1003378/?x=df…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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