November 2021 - Bmegradstudents-list

[Bmeroundtable-list] BME Monday Roundtable - Nov. 29, 2021
by Gelfand, Johanna K 29 Nov '21

29 Nov '21

[under CC BY] BME MONDAY ROUNDTABLE November 29, 2021 Upcoming Events Quick note: We are streamlining communications with the "BME Monday Roundtable" that consolidates information for the school for upcoming important events, new updates from committees, and other important and timely information. Week of Nov. 29 Mon., Nov. 22-Fri., Dec. 3 -College of Engineering food drive to benefit Food Finders Food Bank. Non-perishable food items can be dropped off at ARMS 3000, GRIS 163, MSEE 140, ME 2007, or in the Wang Lobby. Most wanted food items: canned meats (tuna, chicken, salmon, etc.), canned vegetables and fruits, past/rice/cereals, peanut (or other nut) butter, cooking oils, canned or dried beans or peas, 100% fruit juice (no glass containers), shelf-stable milk (powdered/condensed). Wed., Dec. 1, 9:30 a.m. - Virtual seminar: Dr. Ron June, Associate Professor from Montana State University who specializes in Cellular Mechanotransduction and Osteoarthritis. Via Zoom: https://purdue-edu.zoom.us/j/95028921977 Wed., Dec. 1: Bilsland Dissertation Fellowship Nominations Due Wed., Dec. 1, 12:00 noon, MJIS 2001 - Post Doc Panel: "What to Do with a PhD?" ! This will be a Q&A event where graduate students can learn about what a post doc position is, how to apply for one, how funding works for positions like these, why choose a post doc, etc. Hosted by BMEGSA. Pizza will be served. Thurs., Dec. 2, 10:00 a.m. via Zoom: IBSC PhD Defense Announcement for Bhavani Gopalakrishnan (R. Shi and L. Solorio, co-advisors). Title: Therapeutic Immunomodulation of Microglia α-GAL Nanoparticles: Implications for Spinal Cord Injuries. Join Zoom Meeting https://purdue-edu.zoom.us/j/92776776835?pwd=dS9OL1pRQXlkeVU1MEJlTDBZVkNudz… Meeting ID: 927 7677 6835 Passcode: CPR Thurs., Dec. 2, 12:30 p.m., MJIS 2001: BME Defense Announcement for Carolina Vivas Valencia (N. Kong, advisor). Title: Essays on Health Claims Data-Enabled Combat of Current Opioid Epidemic. Everyone is invited to attend the public presentation beginning at 12:30PM EST. Fri., Dec. 3, 8:00 a.m. - Grade entry begins (and ends at 5:00 p.m. December 21). Faculty not meeting the submission deadline for their reporting window will NOT be allowed to enter grades online at a later date. They will need to submit individually via the Grade change workflow found in their myPurdue portal. Tues., Dec. 7 - Deadline to sign up for BME Faculty Preview Event (to be held virtually on Jan. 13th). The faculty preview event gives recruiting faculty the opportunity to share their research with applicants prior to you nominating/inviting students to the open house visit (outside of diversity as those deadlines are prior to this event). Our office will create a schedule and will send invites out to those who have completed applications but you are encouraged to personally invite students you are interested in as well. This event will be followed by a virtual social hour if you would like to get to know some of the applicants better. faculty will sign up for one 10 minute presentation slot; only one zoom room will be set up (no breakout rooms) so speakers will enter and exit the same room for your presentation time. Sign up link: https://docs.google.com/spreadsheets/d/1qiY1p5IrtNToQFF8JCO2vjDZ8coLuIOh5fU… Deadline to Sign Up: December 7th Wed., Dec. 8, 9:30 a.m., MJIS 1001 and via Zoom: BME Distinguished Seminar Series. Steven Steinhubl, MD, Associate Professor, Scripps Research. "The Role of Wearable Sensors in Better Understanding Post Acute Sequelae of COVID-19." Wed., Dec. 8, 3:00 p.m., via Zoom: BME PhD Preliminary Exam Announcement for Hui Ma (T. Kinzer-Ursem and J. Linnes, co-advisors). Title: Computational and Experimental Investigation of Microfluidics into Biophysical Interaction. Thurs., Jan. 13, 3:00-5:00 p.m. - BME Faculty Preview Event (Virtual) Upcoming important deadlines and info. Mon. Dec. 6: QLA major revisions due. Mon. Dec. 6 - Sat. Dec. 11 - "Dead Week" The final examination period is intended for the end-of-semester examination. No examination or quiz may be given during the week preceding the final examination period of the semester (examinations for laboratory, intensive, or minicourses excluded). It will be the responsibility of the department head or, where appropriate, the school head to ensure that none of the departmental or school faculty use the week preceding the final examination period to administer an examination. Tues., Dec. 7: Deadline to sign up for speaker slot for faculty preview event; see above Fri., Dec. 10, 2:00 p.m., MJIS 2001: Biomedical Research Associates Group (BRAG) talk and Q&A with Dr. Douglas Brubaker, "Passions and Priorities: Academic and Industry Careers in Biomedical Sciences." Mon., Dec. 13 - Sat., Dec. 18: FINAL EXAMS: Final Exam Policy here: https://catalog.purdue.edu/content.php?catoid=9&navoid=10509#final-examinat… Thurs., Dec. 16: Senior Design Expo from 3:30-5:30pm in MJIS. I would like to encourage all faculty and staff to attend, interact with design teams, and learn about the accomplishments of the seniors this year. More details to come. Fri., Dec. 17: Graduate applications made available for review Sat. Dec. 18: Deadline for pending Fall 2020 Incomplete Grades to become Failing Grades Tues., Dec. 21 BEFORE 5:00 p.m. - GRADES DUE. (This includes classes and grades for all graduate and undergraduate research students) Wed., Jan. 12: Research area nominations and rankings for diversity fellowships due to grad office Thurs., Jan. 13: Admissions Faculty Preview Event-virtual Mon., Jan. 24 by NOON: Research area nominations and ranking for non-traditional and research excellence fellowships due to grad office (hotel rooms need to be released today so I have to have a name tied to a room by 5 pm) Thurs., Feb. 24 - Sat., Feb. 26: Admissions Open House visit-planning for hybrid (virtual and in-person) event January 2022 - Microsoft Multi-Factor Authentication will be mandatory for all faculty, staff and students on the West Lafayette campus. This will ensure you have continued access to your email plus an added layer of protection from phishing attacks. More details: https://www.itap.purdue.edu/mfa/ Updates from the head The University is continually monitoring the national and local information regarding COVID-19, including new strains such as Omicron, and there are currently no changes in masking or vaccination policy at this time. The awards committee is seeking nominations for the University Faculty Scholars award. Young Kim received it in the previous round this past year. Details are attached. Committee Updates Graduate Admissions: * Recruiting season is upon us. Please be proactive about talking to candidates to build rapport and to increase our recruiting pool. * Each Research Area is advised to make a plan to nominate fellowship candidates by the deadline * Updated fellowship evaluation rubric will be provided late Nov or early Dec. * Jan 13 for George Washington Carver, PDF, Knox * Jan 21 for Remaining fellowships * In lieu of extensive research area introduction, we will have a virtual "meet-the-faculty" meeting in Dec to finalize the in-person visitation list. * This is an optional event. * It will be live for invited (applied) students to meet you but could be pre-recorded (i.e., CoE Showcase event that happened before) to introduce your lab. * The premise is to increase our touchpoints with candidates. * We are looking to revive the "Science on Tap" event during our open house. * So we need a volunteer speaker! * We hear it's a great exposure and highly recommended (by Maria!) Resources, attachments, further information Attachment: Fall 2021 BME Graduate Admissions Timeline Attachment: University Faculty Scholars Process (jfs operational process 2022) Wed., Dec. 1, 9:30 a.m. MJIS 1001 and via Zoom: BME Research Seminar - Ron June, Ph.D., Associate Professor of Mechanical & Industrial Engineering and Microbiology & Cell Biology (Affiliate Faculty), Montana State University, "Understanding osteoarthritis through mechanotransduction and metabolomics" Abstract: Millions of Americans suffer from debilitating joint diseases such as osteoarthritis. These diseases involve deterioration of cartilage, the load-bearing biomaterial that lines the articulating joint surfaces. The function of cartilage is mechanical: it provides low-friction surfaces for articulation and deforms during joint contact to decrease contact pressure and increase joint stability. The first part of this seminar will describe novel mechanobiology approaches toward understanding cartilage and osteoarthritis. The second part of this seminar will describe results from various studies applying metabolomic profiling to synovial fluid in mouse and human studies. Bio: Ron June has longstanding research interests in osteoarthritis and biomechanics related to improving human health. At Dartmouth College he studied Engineering Sciences focused on biomechanics and developed a novel wrist protection strategy, contributed to the design and manufacture of a system for monitoring 3D head accelerations in helmeted sports, and helped to develop a finite element model to understand the biomechanics of spinal pain in rats. As a graduate student at the University of California, Davis, Dr. June studied cartilage biomechanics. Specifically, he investigated a novel mechanism of cartilage flow-independent viscoelasticity. During the course of this project, he discovered novel biomechanical phenomena and made several experimental observations that are consistent with polymer dynamics as a potential physiological mechanism of cartilage viscoelasticity. As a postdoctoral fellow, Dr. June has implemented a surgical model of mouse osteoarthritis and studied protein transduction. He developed a pH-sensitive system for intracellular delivery of macromolecules and has investigated protein transduction in cartilage and chondrocytes. Dr. June's laboratory at Montana State University was completed in March 2012, and his research involves applying modern techniques to advance understanding of osteoarthritis and joint biology. He has applied both targeted and untargeted metabolomic profiling to questions of osteoarthritis and mechanobiology. Dr. June has been named a GAANN Fellow, NIH Kirchstein Fellow, and the Montgomery Street Scholar by the ARCS Foundation. His long-term research interests lie in understanding cartilage and joint mechanobiology to develop novel therapeutic strategies for joint disease. His lab is currently funded by the NIH, NSF, and DoD. ~BME Faculty Host: Dr. Deva Chan ~ Thurs., Dec. 2, 10:00 a.m. via Zoom: IBSC PhD Defense Announcement for Bhavani Gopalakrishnan (R. Shi and L. Solorio, co-advisors). Title: Therapeutic Immunomodulation of Microglia α-GAL Nanoparticles: Implications for Spinal Cord Injuries. Join Zoom Meeting https://purdue-edu.zoom.us/j/92776776835?pwd=dS9OL1pRQXlkeVU1MEJlTDBZVkNudz… Meeting ID: 927 7677 6835 Passcode: CPR Abstract: Immune cells such as infiltrated macrophages are involved in diverse functions following traumatic spinal cord injury (SCI). In their classical activated M1 phenotype, macrophages help in phagocytosis of cell debris, secretion of pro-inflammatory cytokines (IL-6, TNF-α) and generation of reactive oxygen/nitrogen species. In contrast, anti-inflammatory M2 macrophages aid in tissue repair and remodeling. It has been suggested that the improper transition from the M1 to M2 phenotype post-SCI may lead to an inhibitory microenvironment that prevents proper wound resolution and axonal regeneration. Modulating the macrophage phenotype with cytokines after SCI has shown limited success in animal models as cytokine crosstalk is problematic. Alternatively, we propose an antigen based therapy using galactose-alpha-1,3-galactose<https://en.wikipedia.org/wiki/Galactose-alpha-1,3-galactose> (α-gal) nanoparticles (liposomes containing a-gal epitopes) to mediate the injured CNS immune response. a-Gal epitope is a carbohydrate antigen, synthesized in non-primate mammals (mice, rats, pigs, rabbits) and New World monkeys via the enzyme a1,3galactosyltransferase (a1,3GT). Humans, on the other hand, do not synthesize a-gal but instead produce anti-Gal antibody. Early studies with a-gal nanoparticles applied to dermal wounds in anti-Gal producing mice (a1,3GT knock out) showed improved healing without scarring. The chemotactic peptides released during the binding of a-gal to anti-Gal (C5a, C3a) enhanced macrophage recruitment and the bound complex further polarized the macrophages towards a pro-healing state (via Fcg receptor interactions). Since SCI pathophysiology parallels some aspects of wound healing, we hypothesize that α-gal nanoparticles may also enhance the recruitment of anti-inflammatory macrophages to the lesion after SCI and facilitate tissue repair. Unlike wound healing, however, the lesion after SCI contains both migrated macrophages and native microglia. As a first step, we assessed whether microglia can also be activated by α-gal nanoparticles in the presence of serum containing anti-Gal. Using an in vitro model with human microglia cells (HMC3), we found that α-gal nanoparticles with serum activated HMC3 cells as observed by increased CD68 expression. Additionally, the activated cells exhibited a morphological change from circular to an amoeboid form. These cells also displayed anti-inflammatory markers Arginase-1 and CD206 and increased VEGF production while reducing IL-6 levels. The data suggests that the HMC3 cells were polarized towards the M2 phenotype. Subsequently, intracord injection of α-gal nanoparticles into a1,3GT knock out mice subjected to crush SCI revealed promising outcomes. A significant increase in macrophage recruitment was found in the treated cohort in comparison to saline controls. Mice injected with a-gal also showed increased expression of anti-apoptotic Bcl-2, decreased iNOS production and decreased pro-apoptotic Bax expression at 24h and 72h, suggesting neuroprotection. At 7, 14 and 21 days post-injury, the a-gal treated mice expressed higher levels of M2 markers (Arginase-1, CD206) while the pro-inflammatory M1 marker, CD16/CD32 was reduced. Increased neurofilament staining and decreased astrocyte (GFAP) expression in α-gal injected mice was also noted at 45 days after injury. Behavioral experiments showed improved fine-skill locomotor recovery, increased open-field activity and faster paw withdrawal response in the α-gal treated group. Collectively, these results indicate that α-gal nanoparticles induce a pro-healing inflammatory response and has therapeutic potential in ameliorating the effects of SCI. Thurs., Dec. 2, 12:30 p.m., MJIS 2001: BME Defense Announcement for Carolina Vivas Valencia (N. Kong, advisor). Title: Essays on Health Claims Data-Enabled Combat of Current Opioid Epidemic. Everyone is invited to attend the public presentation beginning at 12:30PM EST. Committee Members: Dr. Nan Kong, Chair; Dr. Paul Griffin; Dr. Nicole Adams; Dr. Jacqueline Linnes; Dr. Denny Yu Abstract Health care has become a data-intense industry with billions of data generated at numerous healthcare encounters on a daily basis, through wearable devices, medical imagers, and from biomedical and biobehavioral research studies. These data are essential to driving improvements in population health to address issues related to cost, quality, and outcomes, as well as to promote personalized medicine and precision health. Even though significant progress has been made in harnessing the digitized administrative data, there is still a long way to ensure excellence in precision population health, especially on service utilization and delivery. This PhD dissertation focuses on developing innovative data-driven systems analytics solutions to understand opioid use disorder and its associated harms, with the aim of synthetizing today's evidence to improve tomorrow's prevention and treatment outcomes on opioid use disorder. Over the past 20 years, opioid epidemic has been responsible for numerous cases of overdose deaths among Americans and worldwide. The economic burden of opioid crisis to individuals and society is immense. Furthermore, the opioid overdose epidemic has not impacted communities equally, with increased barriers to care access in an already fragmented system. This thesis comprises five essays that aim to address unanswered questions within the public health and economic literature on opioid overdose disorder diagnosis and treatment. The first essay of the thesis aims to understand how physicians' implicit (unconscious) bias contributes to opioid-based treatment disparities in Indiana. The second essay takes a closer look into health care disparities by examining the impact of social determinants on opioid user disorder diagnosis and treatment. The third essay studies how effectively the enactment of Indiana Public Law 194 reduced the percentage of doctor shoppers for prescription opioids among Indiana Medicaid enrollees. With the use of network analysis, the fourth essay takes a closer look into the interactions between prescription-opioid doctor-shoppers and providers prescribing opioids, under the influence of prescription opioid prescribing guidelines/regulations. Finally, the last essay compares the effect and cost-effectiveness of opioid use disorder treatments based on a self-developed individualized state transition model. These essays collectively provide a data-analytics framework to study population-level opioid use disorder outcomes, investigate the impact of current public approaches on the opioid overdose epidemic, inform policymakers and the general community about the social and structural determinants affecting communities and populations vulnerable to the epidemic. Wed., Dec. 8, 9:30 a.m., MJIS 1001 and via Zoom (https://purdue-edu.zoom.us/j/95028921977 ): BME Distinguished Seminar Series. Steven Steinhubl, MD, Associate Professor, Scripps Research. "The Role of Wearable Sensors in Better Understanding Post Acute Sequelae of COVID-19." Abstract: To date (Nov. 2021), there have been over 258 million confirmed cases of COVID-19 globally, responsible for over 5 million deaths. For >50% of survivors, persistent symptoms, such as fatigue, dyspnea and cognitive impairment can persist for beyond 6 months following their acute infection. The massive scale, marked variability, and primarily subjective nature of these Post-Acute Sequelae of COVID-19 (PASC) has led to countless challenges to its diagnosis, mechanistic evaluation, and treatment. Objective measures of the long-term impact of COVID-19 on an individual's physiology are lacking, especially when an "abnormal" finding is determined relative to accepted population normals. However, by taking advantage of novel "digital vital signs" - measures that are based on an individual's normal rather than a population's normal - long-lasting, significant changes have been identified in subsets of COVID-19 survivors. These findings, identified using data from primarily consumer wearable sensor technologies like activity bands and smartwatches, are preliminary evidence of what can be achieved, in people with, or at risk for PASC, and well beyond, through a focus on individual health. As wearable sensor technologies continue to improve in the quality and quantity of physiologic measures they can track, supported by increasingly sophisticated data analytic techniques, they will become central to the ongoing efforts to transform health care. Bio: Dr. Steinhubl is a career-long clinician-scientist and the founding Director of Digital Medicine at Scripps Research's Translational Institute. In 2021 he began dividing his time between Scripps<https://www.scripps.edu/science-and-medicine/translational-institute/> and physIQ<https://www.physiq.com/> where he is Chief Medical Officer. He also remains clinically active as a cardiologist for the Alaska Native Tribal Health Consortium. He received his undergraduate training in chemical engineering at Purdue University, medical degree at St. Louis University and cardiology training at the Cleveland Clinic. His research has focused on the implementation of clinical programs built specifically around the novel capabilities of digital technologies, especially those made possible through combining novel sensor technologies and AI-based insights to provide personalized, real-time analyses able to detect individual changes in health. Steve has been the principal investigator of dozens of nationwide and global clinical trials, has published over 280 peer-reviewed articles and was the founding Editor-in-Chief of Nature Partner Journal - Digital Medicine. He is also the occasional breakfast cook at his wife's B&B, Susitna Place<https://www.susitnaplace.com/>, in Anchorage Alaska. ~BME Faculty Host: Dr. Matthew Ward ~ Wed., Dec. 8, 3:00 p.m., via Zoom: BME PhD Preliminary Exam Announcement for Hui Ma (T. Kinzer-Ursem and J. Linnes, co-advisors). Title: Computational and Experimental Investigation of Microfluidics into Biophysical Interaction." Place: https://purdue-edu.zoom.us/j/92468866334?pwd=OGt0cWRFUklzV2I0S2dhQnByd0t2UT… Zoom ID: 924 6886 6334 Passcode: 47907 One tap mobile +13126266799,,92468866334# US (Chicago) +16465588656,,92468866334# US (New York) Dial by your location +1 312 626 6799 US (Chicago) +1 646 558 8656 US (New York) +1 301 715 8592 US (Washington DC) +1 346 248 7799 US (Houston) +1 669 900 6833 US (San Jose) +1 253 215 8782 US (Tacoma) Meeting ID: 924 6886 6334 Find your local number: https://purdue-edu.zoom.us/u/a4YNQv4GQ Committee members: Dr. Jacqueline Linnes (co-chair), Dr. Tamara Kinzer-Ursem (co-chair), Dr. Arezoo Ardekani, Dr. Steven Wereley Abstract: Microfluidic techniques have been widely applied in biomedical research such as protein-interaction measurement and point-of-care diagnostics, where experiments and computational models are both leveraged. However, there are still disadvantages and defects in many currently used protocols and models. These microfluidic methods usually need complicated external instrumentation for manipulation or analysis, and to achieve precise control. Solution volume is also much larger if syringe and tubing are necessary. In the theoretical field, models are important to help understand the mechanisms and design the devices. It remains a critical need to improve or develop new models. The goal of this work is in two aspects: optimize protein binding measurement using microfluidic methods and develop new models for rotational diffusion and partially saturated liquid flow in porous media. First, I use particle diffusometry (PD) to measure protein-interaction association constant by common lab equipment. Therefore, the instruments and consumables required in current gold standard are not necessary. Second, to reduce the solution volume needed in microfluidic experiments, I design a chip leveraging air/water two-phase flow, which only needs 2μL solution for protein-interaction analysis. Next, I develop a new method simulating rotational diffusion coefficients of particles based on the Navier-Stokes equation. This model is as accurate as the currently widely used shell model but more efficient and straightforward. Finally, a new model is built to investigate partially saturated flow in porous media. Experiments are implemented to confirm the validity. This model can be applied in hydrology, geology, paper-based biomedical devices and so on. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME Monday Roundtable - Nov. 22, 2021
by Gelfand, Johanna K 22 Nov '21

22 Nov '21

[cid:image004.png@01D7DF89.A908F890] BME MONDAY ROUNDTABLE November 22, 2021 Upcoming Events Quick note from head: We are streamlining communications with the "BME Monday Roundtable" that consolidates information for the school for upcoming important events, new updates from committees, and other important and timely information. In this issue, we have updates from Grad, Undergrad, and DEI committees. These messages will also contain information gathering as appropriate- especially as we start to interview many candidates for the three open searches currently active in the school. In this roundtable- there's a Qualtrics feedback request for the DEI townhall in the DEI committee section. Also- additional upcoming events (e.g., seminars, workshops, etc.) from across the university are available at https://engineering.purdue.edu/BME/AboutUs/News/events instead of being sent via e-mail. This week is short! If you travel during the break, stay safe! David Umulis Week of Nov. 22 Mon., Nov. 22, 1:30 p.m., MSEE Atrium "Research Win Celebration". Mung Chiang, Executive Vice President for Strategic Initiatives and the John A. Edwardson Dean of the College of Engineering and Theresa Mayer, Executive Vice President for Research and Partnerships, cordially invite you to an event celebrating three new centers funded by the National Science Foundation. ASPIRE; EMBRIO Institute; IoT4Ag. Details below in Resources and further information section. Register here: https://purdue.ca1.qualtrics.com/jfe/form/SV_084HJuZsRxbRjzE?utm_source=del… Watch live here: https://www.youtube.com/watch?v=fP-xQLIRykU Wed., Nov. 24th - NO BME Seminar (Thanksgiving break, 11/24-11/26) Week of Nov. 29 Mon., Nov. 29th, 11:00 a.m.-1:00 p.m., MJIS 2001 - Peer Mentoring Grab and Go Lunch (for PhD Mentors and their Mentees) Wed., Dec. 1, 9:30 a.m. - Virtual seminar: Dr. Ron June, Associate Professor from Montana State University who specializes in Cellular Mechanotransduction and Osteoarthritis. Wed., Dec. 1: Bilsland Dissertation Fellowship Nominations Due Thurs., Dec. 2, 10:00 a.m. via Zoom: IBSC PhD Defense Announcement for Bhavani Gopalakrishnan (R. Shi and L. Solorio, co-advisors). Title: Therapeutic Immunomodulation of Microglia α-GAL Nanoparticles: Implications for Spinal Cord Injuries. Join Zoom Meeting https://purdue-edu.zoom.us/j/92776776835?pwd=dS9OL1pRQXlkeVU1MEJlTDBZVkNudz… Meeting ID: 927 7677 6835 Passcode: CPR Thurs., Dec. 2, 12:30 p.m., MJIS 2001: BME Defense Announcement for Carolina Vivas Valencia (N. Kong, advisor). Title: Essays on Health Claims Data-Enabled Combat of Current Opioid Epidemic. Everyone is invited to attend the public presentation beginning at 12:30PM EST. Fri., Dec. 3, 11:30 a.m.-12:15p.m., MJIS 3001: Open office hours w/ head David Umulis. Upcoming important deadlines and info. Mon. Dec. 6: QLA major revisions due. Mon. Dec. 6 - Sat. Dec. 11 - "Dead Week" The final examination period is intended for the end-of-semester examination. No examination or quiz may be given during the week preceding the final examination period of the semester (examinations for laboratory, intensive, or minicourses excluded). It will be the responsibility of the department head or, where appropriate, the school head to ensure that none of the departmental or school faculty use the week preceding the final examination period to administer an examination. Mon. Dec. 6 - Wed. Jan. 19 - Open registration. Open registration for all students with no late fee (encourage your students to sign up early, spots in our upper level course are filling up fast.) Tues., Dec. 7: Deadline to sign up for speaker slot for faculty preview event; more details to come Fri., Dec. 10, 11:30 a.m., MJIS 2001: Faculty meeting. Fri., Dec. 10, 2:00 p.m., MJIS 2001: Biomedical Research Associates Group (BRAG) talk and Q&A with Dr. Douglas Brubaker, "Passions and Priorities: Academic and Industry Careers in Biomedical Sciences." Mon., Dec. 13 - Sat., Dec. 18: FINAL EXAMS: Final Exam Policy here: https://catalog.purdue.edu/content.php?catoid=9&navoid=10509#final-examinat… Thurs., Dec. 16: Senior Design Expo from 3:30-5:30pm in MJIS. I would like to encourage all faculty and staff to attend, interact with design teams, and learn about the accomplishments of the seniors this year. More details to come. Fri., Dec. 17: Graduate applications made available for review Sat. Dec. 18: Deadline for pending Fall 2020 Incomplete Grades to become Failing Grades Tues., Dec. 21 BEFORE 5:00 p.m. - GRADES DUE. (This includes classes and grades for all graduate and undergraduate research students) Wed., Jan. 12: Research area nominations and rankings for diversity fellowships due to grad office Thurs., Jan. 13: Admissions Faculty Preview Event-virtual Mon., Jan. 24 by NOON: Research area nominations and ranking for non-traditional and research excellence fellowships due to grad office (hotel rooms need to be released today so I have to have a name tied to a room by 5 pm) Thurs., Feb. 24 - Sat., Feb. 26: Admissions Open House visit-planning for hybrid (virtual and in-person) event January 2022 - Microsoft Multi-Factor Authentication will be mandatory for all faculty, staff and students on the West Lafayette campus. This will ensure you have continued access to your email plus an added layer of protection from phishing attacks. More details: https://www.itap.purdue.edu/mfa/ Updates from Committees DEI On Oct 29th the school held a Town Hall to discuss the results of the 2021 Climate Survey. Slides presented in the Town Hall are attached and these were followed by a 1 hour discussion about the climate and culture in the Weldon School. We are actively gathering feedback from attendees about the event and from those who could not make it but may still wish to comment. Below is a link to a short Event Feedback survey (will require less than 5 minutes to complete) https://purdue.ca1.qualtrics.com/jfe/form/SV_5nbPGpy9is3ViN8 A report on the Town Hall will be shared in the coming weeks after gathering this feedback and debriefing with Dr. Christopher Munt, Director of Inclusive Excellence at Purdue's Division of Diversity and Inclusion, who facilitated the discussion. Thanks to all for their participation and feedback, Jacqueline C. Linnes, Ph.D. (she/her) Marta E. Gross Associate Professor Director, Diversity Equity and Inclusion Undergraduate Program The Undergraduate Curriculum Committee and the faculty members of the Weldon School of Biomedical Engineering have restructured the curriculum for the B.S. degree in Biomedical Engineering effective for the students entering the School in the Fall Semester 2022. As the growth of our undergraduate program necessitated some structural changes to our courses, we reexamined the entire undergraduate curriculum and introduced BME Pathways to increase depth of training in specialized areas of Biomedical Engineering. There are four pathways that coincide with our faculty areas of research excellence: Bioimaging, Bioelectronics/Bioinstrumentation, Biomechanics/Biomaterials, and Quantitative Biomedicine. Students are required to select a primary Pathway and complete the two required courses as part of their BME undergraduate degree requirements. Students are also required to select a secondary Pathway and complete one of the two required courses for that Pathway. New junior-level courses are introduced as the required Pathway selectable courses, including Introduction to Biomedical Imaging, Experimental Methods in Biomechanics, Foundations of Biomedical Data Science, and Mathematical Models & Methods in Physiology. Also, Junior Experimental Design Lab is introduced for teaching experimental design using projects from all four BME sub-disciplines, as well as BME Professionalization Seminar to build upon soft skills needed for student's career exploration and readiness. In addition, we introduce new sophomore-level Bioinstrumentation And Circuit Theory lab and lecture course and Introduction to Biomechanical Analysis. The changes reflect a number of recommendations from multiple sources including the recent 10-year external review, a joint BME/ECE Diversity, Equity, and Inclusion study, our annual advisory board recommendations, and current and former student and faculty feedback. The redesigned undergraduate curriculum will improve student identity and allow for earlier focus on a sub-field of BME and easier navigation of course options with the introduction of pathways. The changes also allow for greater flexibility for students and improved scheduling of elective courses and faculty teaching assignments within the School. These changes were recently approved by the Engineering Curriculum Committee. Graduate Programs - update Nov 19 2021 The Graduate Committee has begun a systematic review and update of our Graduate Programs that will take place over the Fall and Spring semesters this year. We're particularly focused on expanding our mentoring structures and support throughout an updated timeline of milestones required for our graduate degrees. These updates will better empower our Weldon-school trainees to achieve their full potential, whatever career path they chose. We are initially focusing on revisions of the timeline for milestones and mentoring structure in the Fall semester and January, with an updated plan to be developed by Feb 1st so that it can be rolled out in Fall 2022. Spring semester we will focus on implementation details, as well as improving our curriculum and developing better systematic processes to support students and faculty to ensure the highest quality mentoring for our trainees. We are using a strategic-planning approach, which includes new vision and mission statements for the Weldon School Graduate Program, as well as a list of core values and hallmarks that we will use to guide our planning and decision making now and in the future. We are reviewing data from a number of sources to evaluate where our program is currently, which will help to identify the updates that are needed to best achieve our vision for the Graduate Program. We are interested in your feedback along the way, which can be provided now to any member of the Graduate Committee (list below), but will also be solicited in a more formal way as our plans develop. Thanks to all members of the Weldon community who support our graduate students! BME Graduate Committee · Ed Bartlett · Andrew Brightman · Craig Goergen · Mike Heinz (Chair) · Paula Sarmiento Huertas (BMEGSA rep, President) · Young Kim · Tami Kinzer-Ursem · Nan Kong · Jackie Linnes · Aaron Lottes · Sandy May · Anne Sereno · Tammy Siemers · Luis Solorio ************** Additional updates from the head Thank you to everyone who participated in the Socktober event to collect socks for the Lafayette Transitional Housing Services. BME collected over 330 pairs of socks (plus some mittens, gloves and scarves) that will be distributed to the homeless in our community. If, as you are home over the holidays, you uncover some lightly used jackets, mittens, gloves, or scarves, bring them in and place them outside of Susan Hardy's office (MJIS 2074), and she will take them to LTHS as a continuation of our collection efforts. Thankfulness Tree. The undergraduate BMES group has posted a thankfulness tree outside of the 1st floor MJIS computer lab. Everyone is welcome to select a leaf from the envelope, write a note of thanks and gratitude, and place it on the tree. All students, faculty, and staff are encouraged to participate. Resources, attachments, further information Attached: 2021 All School Town Hall_slides.pdf Institutes Celebration continued.... Purdue serves as the main site for the NSF-funded EMBRIO Institute<https://maillinks.purdue.edu/t/42237623/1487133596/88766132/0/120588/?f5d63…>, which will use AI to expand biology and engineering through exploring how cell signals are integrated to fight off invaders or activated to repair wounds. Researchers will use full 3D simulations of biological structures to establish predictive capabilities, allowing them to see how the shape of networks and tissues can change. ASPIRE<https://maillinks.purdue.edu/t/42237623/1487133596/88757562/0/120588/?f5d63…> is a NSF Engineering Research Center (ERC) dedicated to advancing sustainable, electrified transportation. The center is focused on developing new infrastructure that facilitates widespread adoption of electric vehicles, and research will be linked with educational, mentoring and outreach initiatives for students at all levels. IoT4Ag<https://maillinks.purdue.edu/t/42237623/1487133596/88757563/0/120588/?f5d63…> is a NSF ERC dedicated to addressing food, energy and water security through advanced agricultural technologies. Researchers will create miniature soil-based sensors and swarms of aerial and ground-based robots, as well as new ways of networking them together in communication-constrained environments. Thurs., Dec. 2, 10:00 a.m. via Zoom: IBSC PhD Defense Announcement for Bhavani Gopalakrishnan (R. Shi and L. Solorio, co-advisors). Title: Therapeutic Immunomodulation of Microglia α-GAL Nanoparticles: Implications for Spinal Cord Injuries. Join Zoom Meeting https://purdue-edu.zoom.us/j/92776776835?pwd=dS9OL1pRQXlkeVU1MEJlTDBZVkNudz… Meeting ID: 927 7677 6835 Passcode: CPR Abstract: Immune cells such as infiltrated macrophages are involved in diverse functions following traumatic spinal cord injury (SCI). In their classical activated M1 phenotype, macrophages help in phagocytosis of cell debris, secretion of pro-inflammatory cytokines (IL-6, TNF-α) and generation of reactive oxygen/nitrogen species. In contrast, anti-inflammatory M2 macrophages aid in tissue repair and remodeling. It has been suggested that the improper transition from the M1 to M2 phenotype post-SCI may lead to an inhibitory microenvironment that prevents proper wound resolution and axonal regeneration. Modulating the macrophage phenotype with cytokines after SCI has shown limited success in animal models as cytokine crosstalk is problematic. Alternatively, we propose an antigen based therapy using galactose-alpha-1,3-galactose<https://en.wikipedia.org/wiki/Galactose-alpha-1,3-galactose> (α-gal) nanoparticles (liposomes containing a-gal epitopes) to mediate the injured CNS immune response. a-Gal epitope is a carbohydrate antigen, synthesized in non-primate mammals (mice, rats, pigs, rabbits) and New World monkeys via the enzyme a1,3galactosyltransferase (a1,3GT). Humans, on the other hand, do not synthesize a-gal but instead produce anti-Gal antibody. Early studies with a-gal nanoparticles applied to dermal wounds in anti-Gal producing mice (a1,3GT knock out) showed improved healing without scarring. The chemotactic peptides released during the binding of a-gal to anti-Gal (C5a, C3a) enhanced macrophage recruitment and the bound complex further polarized the macrophages towards a pro-healing state (via Fcg receptor interactions). Since SCI pathophysiology parallels some aspects of wound healing, we hypothesize that α-gal nanoparticles may also enhance the recruitment of anti-inflammatory macrophages to the lesion after SCI and facilitate tissue repair. Unlike wound healing, however, the lesion after SCI contains both migrated macrophages and native microglia. As a first step, we assessed whether microglia can also be activated by α-gal nanoparticles in the presence of serum containing anti-Gal. Using an in vitro model with human microglia cells (HMC3), we found that α-gal nanoparticles with serum activated HMC3 cells as observed by increased CD68 expression. Additionally, the activated cells exhibited a morphological change from circular to an amoeboid form. These cells also displayed anti-inflammatory markers Arginase-1 and CD206 and increased VEGF production while reducing IL-6 levels. The data suggests that the HMC3 cells were polarized towards the M2 phenotype. Subsequently, intracord injection of α-gal nanoparticles into a1,3GT knock out mice subjected to crush SCI revealed promising outcomes. A significant increase in macrophage recruitment was found in the treated cohort in comparison to saline controls. Mice injected with a-gal also showed increased expression of anti-apoptotic Bcl-2, decreased iNOS production and decreased pro-apoptotic Bax expression at 24h and 72h, suggesting neuroprotection. At 7, 14 and 21 days post-injury, the a-gal treated mice expressed higher levels of M2 markers (Arginase-1, CD206) while the pro-inflammatory M1 marker, CD16/CD32 was reduced. Increased neurofilament staining and decreased astrocyte (GFAP) expression in α-gal injected mice was also noted at 45 days after injury. Behavioral experiments showed improved fine-skill locomotor recovery, increased open-field activity and faster paw withdrawal response in the α-gal treated group. Collectively, these results indicate that α-gal nanoparticles induce a pro-healing inflammatory response and has therapeutic potential in ameliorating the effects of SCI. Thurs., Dec. 2, 12:30 p.m., MJIS 2001: BME Defense Announcement for Carolina Vivas Valencia (N. Kong, advisor). Title: Essays on Health Claims Data-Enabled Combat of Current Opioid Epidemic. Everyone is invited to attend the public presentation beginning at 12:30PM EST. Committee Members: Dr. Nan Kong, Chair; Dr. Paul Griffin; Dr. Nicole Adams; Dr. Jacqueline Linnes; Dr. Denny Yu Abstract Health care has become a data-intense industry with billions of data generated at numerous healthcare encounters on a daily basis, through wearable devices, medical imagers, and from biomedical and biobehavioral research studies. These data are essential to driving improvements in population health to address issues related to cost, quality, and outcomes, as well as to promote personalized medicine and precision health. Even though significant progress has been made in harnessing the digitized administrative data, there is still a long way to ensure excellence in precision population health, especially on service utilization and delivery. This PhD dissertation focuses on developing innovative data-driven systems analytics solutions to understand opioid use disorder and its associated harms, with the aim of synthetizing today's evidence to improve tomorrow's prevention and treatment outcomes on opioid use disorder. Over the past 20 years, opioid epidemic has been responsible for numerous cases of overdose deaths among Americans and worldwide. The economic burden of opioid crisis to individuals and society is immense. Furthermore, the opioid overdose epidemic has not impacted communities equally, with increased barriers to care access in an already fragmented system. This thesis comprises five essays that aim to address unanswered questions within the public health and economic literature on opioid overdose disorder diagnosis and treatment. The first essay of the thesis aims to understand how physicians' implicit (unconscious) bias contributes to opioid-based treatment disparities in Indiana. The second essay takes a closer look into health care disparities by examining the impact of social determinants on opioid user disorder diagnosis and treatment. The third essay studies how effectively the enactment of Indiana Public Law 194 reduced the percentage of doctor shoppers for prescription opioids among Indiana Medicaid enrollees. With the use of network analysis, the fourth essay takes a closer look into the interactions between prescription-opioid doctor-shoppers and providers prescribing opioids, under the influence of prescription opioid prescribing guidelines/regulations. Finally, the last essay compares the effect and cost-effectiveness of opioid use disorder treatments based on a self-developed individualized state transition model. These essays collectively provide a data-analytics framework to study population-level opioid use disorder outcomes, investigate the impact of current public approaches on the opioid overdose epidemic, inform policymakers and the general community about the social and structural determinants affecting communities and populations vulnerable to the epidemic. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] REMINDER: Electrical shutdown, 3:00-7:00 AM, Thurs., Nov. 18
by Gelfand, Johanna K 17 Nov '21

17 Nov '21

Due to an electrical shutdown in order to switch out one of the ATS, MJIS will be CLOSED from 3:00 AM until 7:00 AM on Thursday, November 18th. This is a whole building shutdown NO ONE will be allowed to be in the building during this time frame. It is recommended that computers be powered off before you leave this afternoon. Also, very sensitive equipment should also be powered off as there may be a surge when power is restored. Contact Susan Hardy (hardy13(a)purdue.edu<mailto:hardy13@purdue.edu>) if you have any questions. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME Master's Defense Announcement for Nicholas Bluhm (J. Linnes, advisor)
by May, Sandra M 17 Nov '21

17 Nov '21

BME Master's Defense Announcement for Nicholas Bluhm (J. Linnes, advisor) Everyone is invited to attend the public presentation beginning at 11:15am. Title: NeoWarm: Kangaroo Mother Care with Continuous Temperature Tracking Date: November 22, 2021 Time: 11:15am Location: MJIS 2001 Thesis Committee: Jacqueline Linnes, Chair; Yunjie Tong; Sherri L. Bucher Abstract: Premature birth is shockingly prevalent, worldwide more than 1 in 10 live births is premature. There are many complications that accompany premature birth, as essentially every body system is underdeveloped, one of the most impactful of these is hypothermia. Hypothermia is defined as a drop in core temperature below 36.5 ℃. Hypothermia is especially dangerous in premature neonates as this puts significant strain on their already underdeveloped body systems. There are already many solutions to combat neonatal hypothermia. Kangaroo mother care (KMC) is a particularly good solution as it is effective at keeping the neonate warm, while also being a highly affordable and accessible treatment option. KMC is not without its drawbacks however, which we aim to remove through the use of NeoWarm. NeoWarm is essentially a baby carrier with integrated heating pads that has been designed to augment KMC. NeoWarm can be used during KMC or as a stand-alone thermal support device. NeoWarm has been tested on two models. The first model was thin-walled water filled bottles the approximate size and weight of a premature neonate. Using this model NeoWarm’s design was refined and shown to be safe before testing on a live animal model. Neonatal swine was chosen to be a premature human neonate model due to their many similarities, most importantly similar sizes, weights, and thermoregulatory capabilities. Using neonatal swine, it was shown that NeoWarm was effective at warming live hypothermic animals and was completely safe, as not a single animal was burned or otherwise harmed by NeoWarm. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] Upcoming building inspection Nov 17
by Schoenlein, William E 15 Nov '21

15 Nov '21

Good Afternoon, Late Morning this Wednesday, November 17, we will have an OSHA style building inspection by REM. They will be inspecting all areas MJIS, including Offices, meeting areas, public spaces, storage and laboratories. (those of you who do not work n MJIS can ignore this) Please look around your areas for obvious issues that can be corrected before the inspection. Here are a few items to consider. * Are your lab postings up to date? * Are lab coats and eye protection available and in use? * Are all containers properly labelled and tightly closed? * Is waste properly stored and removed in a timely manner? * Is there unnecessary clutter in the lab? * In offices and meeting rooms, is the space uncluttered and free of hazards? If you need help or have questions, I would be pleased to help. Thanks, Bill William Schoenlein PreClinical Studies Manager Weldon School of Biomedical Engineering Purdue University West Lafayette IN 47909 (765) 494-1366 (765) 586-9260 -cell -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] Weldon BME Distinguished Seminar Announcement: November 17th at 9:30 AM - presented virtually
by Holderbaum, Cynthia L 11 Nov '21

11 Nov '21

[cid:image003.jpg@01D7D6DD.F002A2A0] Weldon School of Biomedical Engineering Distinguished Seminar Series Wednesday, November 17, 2021 9:30-10:20am MJIS 1001 https://purdue-edu.zoom.us/j/95028921977 This seminar will be presented virtually The Autonomic Nervous System: A target for neuromodulation [cid:image004.jpg@01D7D6DD.F002A2A0] John Furness, Ph.D. Professor and Head Digestive Physiology and Nutrition Laboratories Florey Institute and the University of Melbourne Abstract: In this talk, I will provide an overview, with some emphasis on engineering principles, of the organisation and function of the ANS. The autonomic nervous system innervates and controls those organs and tissues that are not under overt voluntary control. It adjusts the activities of these organs and tissues so that they operate at levels most favorable to the states of the body and environment. It has parasympathetic, sympathetic and enteric divisions, plus associated afferent systems that detect body and environmental conditions relevant to autonomic control. Autonomic pathways form synapses in cranial, cervical, thoracic, abdominal and pelvic ganglia where signals are integrated and relayed. Many tissues are innervated only by parasympathetic or sympathetic neurons. Some organs are under dual, complementary, control. Ganglia of the enteric division are in the walls of the digestive tract, gallbladder and pancreas. In the intestine the enteric division includes full reflex pathways (afferent neurons, interneurons and motor neurons). Because the ANS acts as a feed-back control system, it is suited to neuromodulatory control to enhance or restrict feedback circuits. I will show some examples. Bio: John Furness is Professor and Head of the Digestive Physiology and Nutrition Laboratories at the Florey Institute and the University of Melbourne. He has appointments in the Medical and Veterinary & Agricultural Sciences Faculties. He is best known for physiological, structural and neurochemical analyses that determined the intrinsic circuits of the enteric nervous system. The circuits that he and his colleagues unraveled have formed a template for later investigations in disease models. His work led to the discovery and identification of sensory neurons intrinsic to the digestive tract. He is also known for the chemical coding hypothesis, the proposal that neurons at defined places in nerve circuits have unique distinguishing chemical characteristics. The current emphases of his research are on (i) use of stem cells for the treatment of neuropathies; (ii) the influence on gut function of neuromodulatory therapies and their applicability to treatment of inflammatory bowel disease and gastroparesis; and (iii) the complexities of co-storage of gut endocrine hormones and their implications in health and disease. He has worked closely with the pharmaceutical, medical devices and animal production industries. He is one of the most highly cited Australian scientists. Google Scholar (November 2021) gives his h-index as 114, including 46,500 citations overall. Honors and Awards include: Fellow of the Australian Academy of Science, 1989 Davenport Medal, American Physiological Society, 1997 Fellow, Academy of Science of Bologna (L'accademia delle scienze dell'istituto di Bologna), the second oldest scientific academy in existence, 2005 Centenary Medal, Govt of Australia, 2003 Fellow of the Australian Academy of Health and Medical Sciences, 2017 Honorary member of the British Physiological Society, 2019. ~BME Faculty Host: Dr. Matthew Ward ~ Sincerely, Cindy Holderbaum Senior Administrative Assistant & Schedule Deputy Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering, (MJIS) Rm. 1021 206 S. Martin Jischke Dr. West Lafayette, IN 47907 o: 765-494-2995<tel:7654942995> cholderb(a)purdue.edu<mailto:cholderb@purdue.edu> www.purdue.edu/bme<http://www.purdue.edu/bme> myStrengths: Harmony | Consistency | Analytical | Deliberative| Maximizer "Things turn out best for those who make the best of the way things turn out." - John Wooden -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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DEI Journal Club
by Benito Alston, Claudia 10 Nov '21

10 Nov '21

Hello All, Just a reminder that tomorrow at 1:30 – 2:30 pm you can come have meaningful discussions and learning at the DEI Journal Club! And there will be free pastries from Sweet Revolution Bakery! You are invited to attend the BMEGSA DEI Journal Club on November 11th from 1:30 – 2:30 pm at MJIS 2001 or zoom with the following link: https://purdue-edu.zoom.us/j/96068179324 Meeting ID: 960 6817 9324. We will be discussing the paper “Making Academia More Accessible” the journal article also has a summary document attached. Please RSVP if you are planning to attend, it helps to inform our food order! Come learn and chat! Sincerely, BMEGSA Diversity Chairs [Qr code Description automatically generated]

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[Bmeroundtable-list] BME PhD Preliminary Exam reminder for Emma Vanderlaan (S. Harbin, advisor)
by May, Sandra M 10 Nov '21

10 Nov '21

BME PhD Preliminary Exam Reminder for Emma Vanderlaan (S. Harbin, advisor) Everyone is invited to the public presentation beginning at 2:00 pm. Title: Advanced 3D Microphysiological System for Rapid Evaluation of Dynamic Pancreatic Beta Cell Function Date: November 11, 2021 Time: 2:00 pm Location: Zoom https://purdue-edu.zoom.us/j/97164630059?pwd=cWVOU0tITGNmSERjVlpwbkVKaGgwUT… Meeting ID: 971 6463 0059 Passcode: 521080 Thesis Committee: Dr. Sherry Harbin (advisor) Dr. Carmella Evans-Molina (clinical co-advisor) Dr. Hyowon Lee Dr. Adrian Buganza Tepole Dr. Luis Solorio Abstract: Beta cells in the pancreas are responsible for regulating blood sugar levels through glucose-sensitive insulin release. Without this important function, blood glucose becomes elevated, giving rise to the metabolic disorder diabetes. Therefore, it is unsurprising that β-cells are the focus of significant basic and translational research, including studies evaluating their potential as a therapeutic cell population. Unfortunately, measurement of β-cell function in the laboratory involves multi-step glucose-stimulated insulin secretion (GSIS) assays, followed by separate quantification of insulin by time-consuming and costly enzyme-linked immunosorbent assays (ELISAs). This often precludes researchers from performing dynamic GSIS measurements, which better represent β-cell physiology but are even more labor-intensive. Experimental microfluidic devices aim to reduce the burden of these dynamic measurements, however ELISAs are still required to process the many samples generated. Thus, there is a critical need for an easy-to-use, rapid, and low-cost alternative method of measuring insulin secretion in real-time. Additionally, most GSIS platforms keep β-cells in suspension, despite the importance of extracellular matrix mechanosignaling for their survival and function. To address this need, we propose to develop and validate an advanced microphysiological system that supports rapid functional assessment of β-cells. The proposed device will restore β-cells to a more physiological microenvironment through encapsulation in a fibrillar collagen scaffold and will integrate a custom electrochemical sensor to directly quantify insulin secretion. If successful, this system would provide a rapid and inexpensive option for performing dynamic GSIS measurements, with potential to accelerate preclinical studies and bring novel therapies to patients with diabetes. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] Phishing Scam - Send me your available cell number
by Cooper, Kitty R 08 Nov '21

08 Nov '21

If you receive an email that looks like it’s from David Umulis or Dean Mung Chiang asking for your cell number, this is a phishing scam - do NOT provide your cell number. If you do, you’ll receive a text asking you to purchase gift cards. ECN is aware of this, but there’s nothing they can do. Just delete the email. Thank you, Kitty Cooper Purdue University Program/Project Assistant Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, Room 3001 West Lafayette, IN 47907-2032 (765) 496-1339 kcooper(a)purdue.edu<mailto:kcooper@purdue.edu> From: David M. Umulis <umulisdavid(a)gmail.com> Sent: Monday, November 8, 2021 5:50 PM To: Cooper, Kitty R <kcooper(a)purdue.edu> Subject: Send me your available cell number -- David M. Umulis  Dane A. Miller Head and Professor Weldon School of Biomedical Engineering -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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DEI Journal Club Nov. 11th 1:30 - 2:30 MJIS 2001
by Enriquez, Angel G 05 Nov '21

05 Nov '21

Hello everyone, You are invited to attend the BMEGSA DEI Journal Club on November 11th from 1:30 - 2:30 pm at MJIS 2001 or zoom with the following link: https://purdue-edu.zoom.us/j/96068179324 Meeting ID: 960 6817 9324. We will be discussing the paper "Making Academia More Accessible" the journal article also has a summary document attached. Feel free to join the discussion and enjoy some coffee & pastries by Sweet Revolution. Please RSVP if you are planning to attend! Thanks, Ángel Enríquez (He/Him/His) Graduate Research Assistant Weldon School of Biomedical Engineering Purdue University

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