December 2024 - Bmegradstudents-list

Fw: New PhD Program in Health Sciences Engineering
by Siemers, Tammy R 20 Dec '24

20 Dec '24

[image001.png] We are pleased to introduce a new joint PhD program in Health Sciences Engineering offered by RPI and the Icahn School of Medicine at Mount Sinai. Based at the Joint Center for Engineering and Precision Medicine in Manhattan, this program focuses on Reparative/Regenerative Medicine, Immuno-engineering, and Neuro-engineering. The program features a first-year engineering immersion, entrepreneurship training and clinical shadowing. This approach fosters a “translational mindset,” equipping students to develop innovative technologies for clinical needs. Additional components include hands-on internships, grand rounds, and health hackathons. We invite you to take a closer look at the new program, which includes a choice of over 60 highly successful PhD mentors and co-mentors<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Ficahn.mss…>. You can apply using this link<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcepmresea…>. The application fee will be waived for all applicants in this inaugural year. Recommendation letters will still be accepted after the deadline. If you have any questions about the program, please get in touch with the program directors [Deepak Vashishth (vashid(a)rpi.edu<mailto:vashid@rpi.edu>) or Priti Balchandani (priti.balchandani(a)mssm.edu)<mailto:priti.balchandani@mssm.edu)>] [image002.png]

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[Bmeroundtable-list] BME PhD Defense Announcement for Andrew Sivaprakasam (M. Heinz and H. Bharadwaj, Co-advisors)
by May, Sandra M 19 Dec '24

19 Dec '24

BME PhD Defense Announcement for Andrew Sivaprakasam (M. Heinz and H. Bharadwaj, Co-advisors) Everyone is invited to attend the public presentation beginning at 8:30 AM EST. Title: Place and Time Processing of Pitch in the Context of Cochlear Dysfunction Date: January 8th, 2025 Time: 8:30 AM EST Location: LYLE 1028 and Zoom: https://iu.zoom.us/j/6883109756?omn=88926223118<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fiu.zoom.u…> Committee: Michael Heinz (Chair), Hari Bharadwaj (Co-Chair), Edward Bartlett, Rick Nelson (IUSM), Andrew Oxenham (Univ. of Minnesota) Abstract: Sensorineural hearing loss occurs in 15% of American adults and current treatment protocols are often guided by limited and outdated diagnostics. Not all types of sensorineural hearing loss are identical in physiology and a major priority of current auditory research is to innovate in the space of precision auditory diagnostics and treatments. Understanding how specific patterns of damage to the cochlea or auditory nerve variably impair the perception of different sound features is critical to improve treatments for hearing-impaired individuals. A history of auditory research has led to considerable insight as to how anatomic components of the auditory periphery, namely inner hair cells (IHCs), outer hair cells (OHCs), and the cochlear synapse function together to transduce, amplify, and code simple sounds. However, there exist considerable gaps in our knowledge of how these peripheral components are responsible for maintaining the fidelity of more complex auditory phenomena and perception. Pitch, the perceived “highness” or “lowness” of a given sound, is an example of a complex psychoacoustic phenomenon. Pitch cues are used to listen to and compose music and to process vowels, identify talkers, and convey emotion. Without intact pitch perception, conversation becomes emotionless, a symphony becomes a cacophony. While pitch has been extensively studied perceptually, our knowledge of the underlying neurophysiology of pitch remains incomplete. Three categories of pitch theories attempt to explain pitch coding in terms of the tonotopic organization of our auditory system (place), the temporal information present in neural firing patterns (time), or a combination of these (place-time). We plan to assess these theories in the context of cochlear pathologies that are expected to differentially alter place and timing cues, hence developing a more comprehensive understanding of pitch. We expected that deficits in time and place coding both affect the neural processing and perception of pitch, but that disrupted place coding plays a stronger role. We investigated this hypothesis by using controlled chinchilla models of hearing loss to investigate SNHL effects on pitch-related electrophysiology. We observed that noise-induced hearing loss primarily disrupts place cues, likely through OHC damage and dysfunction. IHC damage appears to degrade the temporal envelope coding that is used to derive pitch from higher harmonics that are unresolved by cochlear filters. We then collected identical measures in humans with variable hearing status and pitch perceptual ability. Variations in neural and perceptual phenomena relevant to place and time coding of pitch were then related to mechanistic observations from our animal model. Indeed, this cross-species approach reveals significant insights into the physiological mechanisms underlying pitch processing by the auditory periphery. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Weldon Graduate Program Announcements December 18th, 2024
by Siemers, Tammy R 18 Dec '24

18 Dec '24

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements December 18th, 2024 * Career and Internship Opportunities * Professional Development Offering: Google Career Certificates - Limited-Time, No-Cost Enrollment * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * 2025 Tissue Material Sciences Intern, Biomedical Engineering, AbbVie<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Manufacturing Engineer Intern, CooperSurgical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Regulatory Affairs Intern, ConMed<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwd5.mywor…> Postdoctoral Positions * NPA Website: https://careers.nationalpostdoc.org/jobs/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.n…> Full Time Positions * Healthcare Integration Engineer, EvidenceCare<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Product Development Engineer, TIDI Products<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Optical Applications Engineer, Zemax Expertise, Ozen Engineering<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Sustaining Engineer II, Endotronix<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Supervisory Biomedical Engineer, Indian Health Service<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Biomedical Sciences Pos-Bac Intern, Los Alamos National Laboratory<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Associate Clinical Account Specialist, Johnson and Johnson<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjobs.jnj.…> * Purdue Start-up Job Board<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurduefou…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.a…>-Association for Clinical and Translational Science * Academic Careers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Facademicc…> * Doc Jobs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.docjo…>-Jobs beyond traditional clinical and academic roles Professional Development Offering: Google Career Certificates - Limited-Time, No-Cost Enrollment Purdue University students and employees can earn Google Career Certificates in high-demand fields through Purdue. For a limited time, students and employees can enroll in a Google Career Certificate at no cost! From December 2nd, 2024, through January 13, 2025, students and employees can use the discount code FreeGoogleCert when registering to enroll at no cost. Click here to register<https://www.eventreg.purdue.edu/ec2k/Heading.aspx?heading_id=1113>. The following are brief descriptions of each certificate, and more information about each can be found here: https://www.purdue.edu/online/google-career-certificates/ Cybersecurity Certificate. This program offers hands-on experience using Python, Linux, SQL, Security Information and Event Management (SIEM) tools, and intrusion detection systems. It also helps prepare students for the CompTIA Security+ exam. Data Analytics Certificate. This program teaches essential data analysis platforms, including spreadsheets, SQL, Tableau and R programming to help translate business questions into data-influenced actionable plans. Digital Marketing and E-Commerce Certificate. This program provides hands-on experience in popular digital marketing tools such as Canva, Constant Contact, Hootsuite, HubSpot, MailChimp, Shopify, X, Google Ads and Google Analytics - fundamental to helping businesses grow their online presence and sales. Information Technology Support Certificate. This program teaches core concepts to all IT positions, including computer assembly, route paths and subnets, software device management, and effective documentation. You will also gain experience working with Linux, cloud computing and command-line interfaces. Project Management Certificate. Fundamental to most industries, this program covers traditional and Agile project management from initiation to completion, using a toolbox for schedules, budgets and product requirements. The course also qualifies for over 100 education hours for Project Management Institute (PMI) certifications. All courses are self-paced and require no prerequisites or prior experience. They can be completed in less than six months and result in a digital Google certificate. According to Google, these credentials are now recognized by more than 150 major employers<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fgrow.googl…> in the U.S. and growing. Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. Jan. 2nd Deadline to Apply for McClintock Bioscience Postdoctoral Fellowship (Apply Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcg.sandia…>) Jan. 3rd Deadline for Vanderbilt Biomaterials Day Registration & Abstract Submission (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.goog…>) Jan. 8th HDR Open House/Expo During Winter Break (CCO<https://www.cco.purdue.edu/Calendar/Event/692>) Jan. 8th Deadline to apply for Rutgers Postdoc Peek (Apply Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Frutgers.c…>) Jan. 8th NCR-SARE Fellowship (Agricultural Research) Info Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 13th F31/F30 Workshop Series Topic 4: "Research Strategy Approach" Presentation (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 13th Last day to enroll in a Google Career Certificate at no cost (use code FreeGoogleCert here<https://www.eventreg.purdue.edu/ec2k/Heading.aspx?heading_id=1113>) Jan. 14th Managing Uncertainty During Graduate School (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th AI Tools for Lit Reviews (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th Convert Your CV to a Resume (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th Credit - Understanding Cards & Scores (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th Getting the Mentoring You Need (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th Deadline to apply for Branco Weiss Postdoctoral Fellowship (Apply Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbrancowei…>) Jan. 15th NIH Fellowship Opportunities for Graduate Students (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th NIH Fellowship Opportunities for PhD Candidates and Postdoctoral Scholars (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 16th The Cover Letter (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 17th Budgeting and Saving Money (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 17th Navigating the IRB Process and Submitting Your Study (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 21st Boiler Up & Intervene (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 21st Preparing for Academic Interviews (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 22nd Discovering the Treasures of Federal Legal, Legislative, and Regulatory Resources (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 22nd Personal Branding (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 22nd Quad Fellowship Info Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 22nd Purdue Indianapolis Resumania: Drop-In Resume Reviews (CCO<https://www.cco.purdue.edu/Calendar/Event/707> - Room ET 103 at 11 am) Jan. 23rd Debt Management (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 23rd CCO 2025 International Student Workshop - Career Fair Prep (CCO<https://www.cco.purdue.edu/Calendar/Event/701>) Jan. 24th Business Databases: Ace Your Job Interview, Find Investors for Your Research/Idea (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 27th F31/F30 Workshop Series Topic 4: "Research Strategy Approach" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 27th Healthy Financial Habits (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 27th - 29th 2025 Co-op Days Recruiting Event (CCO<https://www.cco.purdue.edu/Calendar/Event/528>) Jan. 28th Best Practices in Research Data Management (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 28th Eating Right When Your Budget is Tight (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 28th The A-Z of the Job Search (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 28th 2024 Co-op Days Recruiting Event (CCO<https://www.cco.purdue.edu/Calendar/Event/528>) Jan. 30th Citation Management with Zotero (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 30th Interviewing Skills (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 30th Purdue Indianapolis Resumania: Drop-In Resume Reviews Jan. 31st Application deadline for Johnson & Johnson Japan Smart Healthy Aging QuickFire Challenge (Apply<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjnjinnova…>) Jan. 31st Let's Talk Taxes (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 31st RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 31st Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 3rd Healthy Relationships (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 5th Conducting a Literature Review (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 5th Healthy Financial Habits (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 7th Credit - Understanding Cards & Scores (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 10th Research with Scite.ai (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 10th F31/F30 Workshop Series Topic 5: "Biosketch and Other Documents" Working Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 11th Combating Bias and Hate on College Campuses (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 12th Preparing to Buy a House (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 12th Retirement Planning (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 14th An Overview of ResearchRabbit (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 14th Postdoc Power Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 17th Diet, Stress, & Emotional Eating (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 18th How to Improve Your Public Speaking (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 19th Careers in Public Health (CCO<https://www.cco.purdue.edu/Calendar/Event/483>) Feb. 19th NIH Fellowship Opportunities for Graduate Students (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 19th NIH Fellowship Opportunities for PhD Candidates and Postdoctoral Scholars (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 20th Healthy Eating on the Run (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 21st RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 24th Patent Agent Careers in Life Sciences (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 25th 4th Annual Grad WiE Network Symposium (WiE<https://www.purdue.edu/wiep/CurrentStudents/Graduate%20Women%20in%20Enginee…>) Feb. 26th MoISSI Fellowship Information Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 26th Quad Fellowship Info Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 28th Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 3rd Preparing to Buy a Car (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 3rd Publishing a Scientific Paper (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 4th Debt Management (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 4th Presenting Your Research: How to Sell Others on Your Ideas (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 5th Credit - Understanding Cards & Scores (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 7th Copyrights: An Overview for Scholars (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 7th Let's Talk Taxes (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 10th Citation Management with Zotero (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 10th Conducting a Literature Review (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 10th NIH Fellowship Opportunities for PhD Candidates and Postdoctoral Scholars (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 12th Experiences in Healthcare and Public Health (CCO<https://www.cco.purdue.edu/Calendar/Event/484>) News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education BME Students (ONLY): Schedule appointments with me via BoilerConnect here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>. Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [cid:image002.png@01DB518E.63D63470]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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[Bmeroundtable-list] Today! Final 2024 BME 3rd Year PhD Student Seminar: Friday 12-13
by Rowen, Elizabeth Pearl 13 Dec '24

13 Dec '24

[cid:image001.jpg@01DB05C3.B4BD0650] BME 3rd Year Seminar Series Friday, December 13th, 2024 1:30 - 2:30 PM EST MJIS 1001 Evaluation links: Samridhi Kulshrestha: https://purdue.ca1.qualtrics.com/jfe/form/SV_9vHbXGpJXmvgBZs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Zhuoan Li: https://purdue.ca1.qualtrics.com/jfe/form/SV_8v4jNrVY6UYRbzE<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Evaluation surveys should only be completed after the seminar has taken place, and only by those who attended the seminar. We appreciate those who are able to attend and provide feedback; These surveys will help us determine the recipient of the 2024 Fearnot Prize for the best presentation! Development of a sustained-release polymeric implant for long-term intra-ocular pressure reduction Samridhi Kulshrestha (Andrew Otte/Luis Solorio, advisors) [cid:image005.jpg@01DB4A28.D90089C0] Abstract: Glaucoma is one of the leading causes of irreversible blindness worldwide and is the top cause of blindness among adults in the U.S. Reduction in intraocular pressure has been proven to be the only effective way to prevent further vision loss due to glaucoma, achieved through the use of prostaglandins, beta blockers, and alpha-adrenergic agonists via eye drops or in combination with oral carbonic anhydrase inhibitors. Unfortunately, these treatments have issues, such as patient non-compliance, rapid drug clearance, and off-target effects. The current state-of-the-art treatments include non-biodegradable implants (e.g. Iluvien) or a one-time use per eye biodegradable implants (e.g. Durysta). Durysta is constrained to a single-time use potentially due to the generation of acidic degradation by-products from the controlled release excipient (poly(lactide-co-glycolide)). Additionally, a critical need exists to develop implants delivering carbonic anhydrase inhibitors, such as dorzolamide, that are more frequently prescribed due to better patient tolerability compared to prostaglandins. To address these limitations, my project aims to explore alternative biodegradable polymers such as polycaprolactone (PCL) and poly(ortho esters) (POEs), as they degrade into more neutral by-products and offer tunable drug release properties. The hot melt extrusion technology used for manufacturing the implant cuts off any post-processing costs as it is a solvent-free method. The goal is to leverage biodegradable and biocompatible polymers that degrade into more neutral by-products and optimize manufacturing techniques like solvent-free hot melt extrusion to achieve a long-term drug delivery system with minimal adverse effects, improved patient compliance, and allows for repeat administration. Quantification of Extracellular Volume Fraction in Cardiac MRI without Blood Sampling Using Multi-Stage Training Deep Learning Zhuoan Li (Behzad Sharif/Craig Goergen, advisors) [cid:image006.jpg@01DB4A28.D90089C0] Abstract: Blood sampling for hematocrit (HCT) measurement presents a significant barrier to the widespread clinical use of extracellular volume fraction (ECV) in diagnosing myocardial diseases. We aimed to overcome this limitation by developing and evaluating a deep learning (DL) model to predict HCT directly from cardiovascular magnetic resonance (CMR) data. The approach focused on leveraging multi-center CMR T1 values alongside clinical features to enhance prediction accuracy and assess the impact of additional features on model performance. A multi-stage DL model was trained using data from multiple centers, incorporating native blood-pool T1 values and clinical parameters such as gender. Results demonstrated that the DL model had a stronger correlation with true HCT than traditional linear regression methods. Furthermore, the synthetic ECV derived from the predicted HCT showed excellent agreement with true ECV values, validating the model's reliability and clinical relevance. We highlight the potential of DL models to enhance HCT prediction by integrating additional features, eliminating the need for invasive blood sampling. By streamlining the measurement of ECV, this advancement offers a more accessible and efficient approach to diagnosing myocardial diseases, paving the way for broader adoption of CMR in clinical practice. Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Weldon Graduate Program Announcements December 11th, 2024
by Siemers, Tammy R 11 Dec '24

11 Dec '24

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements December 11th, 2024 * Career and Internship Opportunities * ECE595 Optical imaging system design in Spring 2025 * FDA Summer Research Program * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Research Intern, Biomedical Signal Processing, Microsoft<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Biomedical/Mechanical Modeling Intern (Summer 2025), Solventum (3M Healthcare<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…>) * Biomedical Engineer Intern, Entegris<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Intern, Biological Safety Engineering, Philips<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Biomedical Engineering Intern, Z-Score Health<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> Postdoctoral Positions * NPA Website: https://careers.nationalpostdoc.org/jobs/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.n…> Full Time Positions * Product Development Engineer, TIDI Products<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Interfaces Project Manager, Biomedical Engineering, Blue Water Thinking<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Field Clinical Engineer, Orchestra Biomed<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Remote Care Product Engineer, Abbott<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Sustaining Engineer II, Endotronix<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Field Clinical Engineer, Saluda Medical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Sustaining Engineer, Spectrum Vascular<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Founding Engineer Lead, Health Startup, Metabolic Psychiatry Labs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Principal Design Control Quality Engineer, Predicine<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Clinical Sales Engineer, Swift Medical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Associate Product Manager, Fresenius Medical Care<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Healthcare Integration Engineer, EvidenceCare<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Data Scientist, Sage Bionetworks<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Associate Clinical Business Intelligence Specialist, Medtronic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Optical Applications Engineer, Ozen Engineering<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Senior Field Application Scientist, Ultima Genomics<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Imaging Scientist, Cardiovascular Imaging, Clario<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Neuromodulation Technology Engineer, Biotronik<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Purdue Start-up Job Board<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurduefou…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.a…>-Association for Clinical and Translational Science * Academic Careers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Facademicc…> * Doc Jobs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.docjo…>-Jobs beyond traditional clinical and academic roles ECE595 Optical imaging system design in Spring 2025 See attached FDA Summer Research Program Please use the link below to see an opportunity for the FDA Office of Science and Engineering Laboratories Summer Research Program: https://www.fda.gov/medical-devices/science-and-research-medical-devices/os…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.fda.g…> Note, applicants must be able to meet applicable security requirements of the agency, which include completion of a background check. Completion of a background check requires individuals to have resided for a minimum of three of the past five years within the United States. Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. Dec. 11th Experiences in Epidemiology and Biostatistics (CCO<https://www.cco.purdue.edu/Calendar/Event/481>) Dec. 11th BME GSA COVID Vaccine Clinic - Open to Walk-ins (MJIS 2001 @ 1 pm) (Reserve a Time<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbme-clini…>) Dec. 13th Virtual Postdoc Expo at MSU (RSVP Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpostdocs.…>) Dec. 13th Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 16th F31/F30 Workshop Series Topic 3: "Research Strategy--Significance & Motivation" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 2nd Deadline to Apply for McClintock Bioscience Postdoctoral Fellowship (Apply Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcg.sandia…>) Jan. 3rd Deadline for Vanderbilt Biomaterials Day Registration & Abstract Submission (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.goog…>) Jan. 8th HDR Open House/Expo During Winter Break (CCO<https://www.cco.purdue.edu/Calendar/Event/692>) Jan. 8th Deadline to apply for Rutgers Postdoc Peek (Apply Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Frutgers.c…>) Jan. 8th NCR-SARE Fellowship (Agricultural Research) Info Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 13th F31/F30 Workshop Series Topic 4: "Research Strategy Approach" Presentation (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 14th Managing Uncertainty During Graduate School (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th AI Tools for Lit Reviews (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th Convert Your CV to a Resume (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th Credit - Understanding Cards & Scores (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th Getting the Mentoring You Need (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th Deadline to apply for Branco Weiss Postdoctoral Fellowship (Apply Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbrancowei…>) Jan. 15th NIH Fellowship Opportunities for Graduate Students (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 15th NIH Fellowship Opportunities for PhD Candidates and Postdoctoral Scholars (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 16th The Cover Letter (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 17th Budgeting and Saving Money (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 17th Navigating the IRB Process and Submitting Your Study (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 21st Boiler Up & Intervene (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 21st Preparing for Academic Interviews (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 22nd Discovering the Treasures of Federal Legal, Legislative, and Regulatory Resources (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 22nd Personal Branding (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 22nd Quad Fellowship Info Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 23rd Debt Management (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 24th Business Databases: Ace Your Job Interview, Find Investors for Your Research/Idea (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 27th F31/F30 Workshop Series Topic 4: "Research Strategy Approach" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 27th Healthy Financial Habits (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 28th Best Practices in Research Data Management (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 28th Eating Right When Your Budget is Tight (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 28th The A-Z of the Job Search (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 28th 2024 Co-op Days Recruiting Event (CCO<https://www.cco.purdue.edu/Calendar/Event/528>) Jan. 30th Citation Management with Zotero (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 30th Interviewing Skills (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 31st Application deadline for Johnson & Johnson Japan Smart Healthy Aging QuickFire Challenge (Apply<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjnjinnova…>) Jan. 31st Let's Talk Taxes (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 31st RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 31st Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 3rd Healthy Relationships (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 5th Conducting a Literature Review (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 5th Healthy Financial Habits (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 7th Credit - Understanding Cards & Scores (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 10th Research with Scite.ai (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 10th F31/F30 Workshop Series Topic 5: "Biosketch and Other Documents" Working Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 11th Combating Bias and Hate on College Campuses (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 12th Preparing to Buy a House (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 12th Retirement Planning (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 14th An Overview of ResearchRabbit (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 14th Postdoc Power Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 17th Diet, Stress, & Emotional Eating (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 18th How to Improve Your Public Speaking (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 19th Careers in Public Health (CCO<https://www.cco.purdue.edu/Calendar/Event/483>) Feb. 19th NIH Fellowship Opportunities for Graduate Students (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 19th NIH Fellowship Opportunities for PhD Candidates and Postdoctoral Scholars (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 20th Healthy Eating on the Run (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 21st RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 24th Patent Agent Careers in Life Sciences (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 25th 4th Annual Grad WiE Network Symposium (WiE<https://www.purdue.edu/wiep/CurrentStudents/Graduate%20Women%20in%20Enginee…>) Feb. 26th MoISSI Fellowship Information Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 26th Quad Fellowship Info Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 28th Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 3rd Preparing to Buy a Car (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 3rd Publishing a Scientific Paper (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 4th Debt Management (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 4th Presenting Your Research: How to Sell Others on Your Ideas (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 5th Credit - Understanding Cards & Scores (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 7th Copyrights: An Overview for Scholars (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 7th Let's Talk Taxes (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 10th Citation Management with Zotero (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 10th Conducting a Literature Review (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 10th NIH Fellowship Opportunities for PhD Candidates and Postdoctoral Scholars (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Mar. 12th Experiences in Healthcare and Public Health (CCO<https://www.cco.purdue.edu/Calendar/Event/484>) News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education BME Students (ONLY): Schedule appointments with me via BoilerConnect here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>. Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [cid:image002.png@01DB4BE2.3ADF5AD0]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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[Bmeroundtable-list] BME 3rd Year PhD Student Seminar Series: Friday 12-13
by Rowen, Elizabeth Pearl 09 Dec '24

09 Dec '24

[cid:image001.jpg@01DB05C3.B4BD0650] BME 3rd Year Seminar Series Friday, December 13th, 2024 1:30 - 2:30 PM EST MJIS 1001 Evaluation links: Samridhi Kulshrestha: https://purdue.ca1.qualtrics.com/jfe/form/SV_9vHbXGpJXmvgBZs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Zhuoan Li: https://purdue.ca1.qualtrics.com/jfe/form/SV_8v4jNrVY6UYRbzE<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Evaluation surveys should only be completed after the seminar has taken place, and only by those who attended the seminar. We appreciate those who are able to attend and provide feedback; These surveys will help us determine the recipient of the 2024 Fearnot Prize for the best presentation! Development of a sustained-release polymeric implant for long-term intra-ocular pressure reduction Samridhi Kulshrestha (Andrew Otte/Luis Solorio, advisors) [cid:image005.jpg@01DB4A28.D90089C0] Abstract: Glaucoma is one of the leading causes of irreversible blindness worldwide and is the top cause of blindness among adults in the U.S. Reduction in intraocular pressure has been proven to be the only effective way to prevent further vision loss due to glaucoma, achieved through the use of prostaglandins, beta blockers, and alpha-adrenergic agonists via eye drops or in combination with oral carbonic anhydrase inhibitors. Unfortunately, these treatments have issues, such as patient non-compliance, rapid drug clearance, and off-target effects. The current state-of-the-art treatments include non-biodegradable implants (e.g. Iluvien) or a one-time use per eye biodegradable implants (e.g. Durysta). Durysta is constrained to a single-time use potentially due to the generation of acidic degradation by-products from the controlled release excipient (poly(lactide-co-glycolide)). Additionally, a critical need exists to develop implants delivering carbonic anhydrase inhibitors, such as dorzolamide, that are more frequently prescribed due to better patient tolerability compared to prostaglandins. To address these limitations, my project aims to explore alternative biodegradable polymers such as polycaprolactone (PCL) and poly(ortho esters) (POEs), as they degrade into more neutral by-products and offer tunable drug release properties. The hot melt extrusion technology used for manufacturing the implant cuts off any post-processing costs as it is a solvent-free method. The goal is to leverage biodegradable and biocompatible polymers that degrade into more neutral by-products and optimize manufacturing techniques like solvent-free hot melt extrusion to achieve a long-term drug delivery system with minimal adverse effects, improved patient compliance, and allows for repeat administration. Quantification of Extracellular Volume Fraction in Cardiac MRI without Blood Sampling Using Multi-Stage Training Deep Learning Zhuoan Li (Behzad Sharif/Craig Goergen, advisors) [cid:image006.jpg@01DB4A28.D90089C0] Abstract: Blood sampling for hematocrit (HCT) measurement presents a significant barrier to the widespread clinical use of extracellular volume fraction (ECV) in diagnosing myocardial diseases. We aimed to overcome this limitation by developing and evaluating a deep learning (DL) model to predict HCT directly from cardiovascular magnetic resonance (CMR) data. The approach focused on leveraging multi-center CMR T1 values alongside clinical features to enhance prediction accuracy and assess the impact of additional features on model performance. A multi-stage DL model was trained using data from multiple centers, incorporating native blood-pool T1 values and clinical parameters such as gender. Results demonstrated that the DL model had a stronger correlation with true HCT than traditional linear regression methods. Furthermore, the synthetic ECV derived from the predicted HCT showed excellent agreement with true ECV values, validating the model's reliability and clinical relevance. We highlight the potential of DL models to enhance HCT prediction by integrating additional features, eliminating the need for invasive blood sampling. By streamlining the measurement of ECV, this advancement offers a more accessible and efficient approach to diagnosing myocardial diseases, paving the way for broader adoption of CMR in clinical practice. Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] Invitation to the 4th Annual Health Equity Summit
by Gelfand, Johanna K 09 Dec '24

09 Dec '24

Hello Everyone, We are excited to invite you to the 4th Annual Health Equity Summit, February 20th from 8:00 AM to 3:30 PM at the Purdue Indy campus. This year, we are honored to feature Amanda Williams, MD, MPH, FACOG, Interim Chief Medical Officer at March of Dimes, as our keynote speaker. What to Expect: * Complimentary breakfast/lunch and collaborative opportunities * Innovative discussions on health equity topics * Poster session with an awards ceremony We've attached our flyer for more details. To register, scan the QR code on the flyer or use this link<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcvent.me%…>. Please share this event within your networks, organizations, and on social media to help us reach a wider audience. Thank you, and we look forward to another great summit! If you have any questions, please feel free to contact me (bplante(a)purdue.edu<mailto:bplante@purdue.edu>). Thank you! Brandi Plantenga Executive Assistant to Dr. Jerome M. Adams, Executive Director Holly Wood, Senior Director Health Equity Initiatives Center for Community Health Enhancement and Learning (HEAL) O: 765-494-7307 M: 765-491-4946 To schedule a meeting: https://calendly.com/bplante-purdue<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcalendly.…> [cid:image001.png@01DB4709.6011D220] [cid:image002.png@01DB4709.6011D220]<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Ftwitter.c…>[cid:image003.png@01DB4709.6011D220]<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] You're Invited! BME Senior Design Expo, Thurs., Dec. 12
by Gelfand, Johanna K 09 Dec '24

09 Dec '24

Dear Weldon School Community, Please join us to celebrate the outstanding work of our senior students at this year's BME Senior Design Expo on Thursday, December 12 at 3:30pm in MJIS. Welcoming remarks and an overview of projects will take place at 3:30pm in MJIS 1001 followed by an open expo starting at approximately 4pm throughout the first floor of MJIS. This year we have a record-breaking 34 projects on display! Your feedback and encouragement of our seniors is invaluable. We look forward to seeing you there! [cid:51171c1f-c855-4623-9245-5e5887d97c9e] -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME 3rd Year PhD Student Seminar Series: Friday 12-6
by Rowen, Elizabeth Pearl 06 Dec '24

06 Dec '24

[cid:image001.jpg@01DB05C3.B4BD0650] BME 3rd Year Seminar Series Friday, December 6th, 2024 1:30 - 2:30 PM EST MJIS 1001 Evaluation links: Jhon Martinez: https://purdue.ca1.qualtrics.com/jfe/form/SV_do6p6jpGVUVNIea<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Nikita Krishnan: https://purdue.ca1.qualtrics.com/jfe/form/SV_e8Qkmqbi8DiZc3A<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Evaluation surveys should only be completed after the seminar has taken place, and only by those who attended the seminar. We appreciate those who are able to attend and provide feedback; These surveys will help us determine the recipient of the 2024 Fearnot Prize for the best presentation! Mechanistic Insights into Neuroprotective Strategies: Studying Neuronal Network Activity Changes in an In Vitro Model of Blast-Induced TBI Jhon Martinez (Riyi Shi, advisor) [cid:image003.jpg@01DB4021.524EB570] Abstract: Traumatic brain injury (TBI) is a significant global public health issue, affecting up to 74 million individuals each year. Blast-induced TBI (bTBI), common in war zones, results from explosive shockwaves and can lead to secondary injury through chemical cascades and brain inflammation Both primary and secondary injuries contribute to long-term behavioral and cognitive issues and elevate neurodegenerative disease risk, even in mild cases (mbTBI). Key aspects of secondary injury include oxidative stress, reactive oxygen species (ROS), and acrolein-a reactive aldehyde that exacerbates cellular damage. However, the link between cellular damage and brain pathology is not fully understood. This study investigates cellular-level changes due to mbTBI using a TBI-on-a-chip model, where primary murine cortical neurons are cultured on microelectrode arrays (MEAs) to record neuronal activity. Results indicate that mbTBI induces immediate functional disruptions, including reduced spike rate and altered burst patterns-reduced burst rate, shortened burst duration, and longer burst intervals. Cross-correlation analysis of MEA recordings showed disturbances in firing order dynamics, such as changes in firing hierarchy and correlogram peaks, suggesting disrupted neuron coordination. Additionally, using the acrolein-scavenging drug hydralazine helped restore some network functions, highlighting acrolein neutralization as a potential therapeutic strategy. These findings suggest mbTBI alters neuronal firing patterns, potentially contributing to neurodegeneration, and highlight the potential of targeting secondary injury mechanisms to protect neuronal function. An in vitro Model of the Blood-Brain Barrier after Blast Traumatic Brain Injury Nikita Krishnan (Riyi Shi, advisor) [cid:image002.jpg@01DB44AC.A552C3D0] Abstract: Blast traumatic brain injury (bTBI) is a highly-prevalent condition caused by shock waves from explosions. Even mild bTBI can increase the risk of developing neurodegenerative diseases like Alzheimer's Disease (AD), making the high prevalence of bTBI and repetitive bTBI amongst military personnel an urgent concern. A key pathological feature seen after bTBI is disruption of the blood-brain barrier (BBB), which normally functions to restrict the passage of biomolecules between the brain tissue and the systemic vasculature. After bTBI, the permeability of the BBB is temporarily increased, and the tight junction proteins (TJPs) normally present between the endothelial cells (ECs) that make up the BBB are temporarily expressed at lower levels. The disruption of the BBB and subsequent recovery of permeability and TJP expression are mediated by secondary injury mechanisms, or biochemical cascades that initiate immediately after primary mechanical exposure. Specifically, the activation of innate immune cells in the brain called microglia, which can be pro- or anti-inflammatory, and the generation of toxic lipid peroxidation product acrolein may play a critical role in mediating BBB dysfunction and recovery after bTBI. However, the exact roles of activated microglia and acrolein in post-injury BBB dysfunction have not been identified. The purpose of this thesis is to identify the effects of microglial activation state and acrolein levels on temporal BBB dynamics after mild bTBI by leveraging an in vitro model system of the cells of the BBB (ECs, astrocytes, and pericytes) and microglia. Microglial activation and acrolein levels will then be therapeutically targeted by biochemically promoting the anti-inflammatory activated microglial phenotype and reducing acrolein levels. This therapeutic approach will be investigated immediately after a single mild bTBI, after a single mild bTBI followed by a subsequent bTBI, and after multiple consecutive bTBIs. Treatment is expected to promote a quicker recovery of BBB permeability, TJP expression, and vascular stability marker expression both after a single injury and after repetitive injury. Understanding and promoting BBB recovery mechanisms after bTBI has the potential to mitigate pathology initiated or exacerbated by BBB permeability, and this could be critical to preventing severe consequences of single and repetitive mild bTBI. Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME PhD Defense Announcement for Sang Hoon Um (L. Green, advisor)
by May, Sandra M 05 Dec '24

05 Dec '24

BME PhD Defense Announcement for Sang Hoon Um (L. Green, advisor) Everyone is invited to attend the public presentation beginning at 10:00 am. Thesis title: BIO-MOLECULAR TRANSPORATION VIA DNA NANOPORES IN LIVE CELL SYSTEM AND THEIR BIO-APPLICATIONS Date: 12/05/2024 Time: 10:00 am Place: MJIS 2001 and Zoom link: https://purdue-edu.zoom.us/launch/chat?src=direct_chat_link&email=ums@purdu…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Faculty Advisor (Chair): Prof. Leopold Green Members: Prof. Chengde Mao Prof. Fang Huang Prof. Krishna Jayant Abstract: The utilization of DNA nanopores as synthetic channels within live cell membranes represents a significant advancement in biomedical research. These nanopores, engineered with precision and versatility, offer a promising avenue for selective and efficient transport of biomolecules across cellular barriers. Leveraging the programmability and biocompatibility of nucleotides, DNA nanopores provide tailored solutions for targeted delivery mechanisms. By overcoming various challenges inherent in cellular mechanisms and synthetic pore creation technologies, including the high dependency on endocytosis machinery, the limitations posed by the size of proteins in transmembrane processes, and the biocompatibility issues associated with current technologies used to form pores, they facilitate the transportation of diverse biomolecules, including the reliance on endocytosis machinery, size limitations of transmembrane proteins, and biocompatibility issues associated with current pore-forming technologies, DNA nanopores facilitate the transport of diverse biomolecules, such as small molecules and proteins, with notable efficacy and biocompatibility. This innovation holds immense potential for various biomedical applications, offering a sophisticated platform for advanced research and therapeutic interventions throughout various cell types including eukaryotic cells and prokaryotic cells. Through elucidating the nuanced importance and diverse applications of DNA nanopores in live cell membranes, this study contributes to the ongoing progress in biomedical science and therapeutic innovation. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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