April 2024 - Bmegradstudents-list

[Bmeroundtable-list] Connector cables in MJIS 2001
by Gelfand, Johanna K 30 Apr '24

30 Apr '24

If you have inadvertently removed any of the connector cables from MJIS 2001 (e.g., neglected to disconnect them from your laptop after a presentation), could you please return them to Jo or Susan? The room is heavily booked (as always at the end of the semester) and we NEED them! Specifically, we are missing both the USBC and HDMI cables. Thanks! Jo -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME Weekly Roundtable - April 29, 2024
by Gelfand, Johanna K 29 Apr '24

29 Apr '24

[cid:image001.jpg@01DA9A1E.76EF94C0] BME WEEKLY ROUNDTABLE April 29, 2024 FINALS WEEK! INTERIM HEAD'S NOTE First of all, I wish all of you good luck in the finals week (taking final exams, proctoring and grading final exams, etc.). Special best-wishes to the graduate students who are going through their milestones (prelim, defense, etc.) in the coming days. Following what I did in last week's note, I want to highlight more accomplishments of our faculty and students. Congratulations! Much appreciation is sent to all the faculty, postdocs, graduate students who nominated our wonderful undergraduate students, wrote support letters for them, and more importantly teach, mentor, and provide academic and professional development opportunities to them. * Dr. Taimoor Hassan Qazi received the Outstanding Mentor of Engineering Award. * Ana Claure Dips received the National Science Foundation Graduate Research Fellowship. * Andrew Gangstad received the Purdue G.A. Ross Award. * Dean Stornello received the Bruce Helfert Memorial Award * Many more to come. Here is a highlight of upcoming events. * BME mini-retreat, Lafayette Country Club, May 3 at 2 - 5 pm. Please come out to have fun with 40+ of your colleagues. There will be fun and surprises. There will be prizes to give away. * BME Graduate Celebration Class of 2024, MJIS Atrium, May 11 at 9 - 11:30 am. Our graduating students, their families and friends are all invited. Faculty and graduate students, you are also invited. Come out to celebrate the graduation with them, especially those whom you have helped. Here is a friendly reminder. Jo sent out an email last week on behalf of Vitaliy in regard to teaching history and projection. Based on the discussions of the working group for teaching, we have provided you with an Excel table showing previous and current teaching assignments, from Fall 2019 to Fall 2024. This is a living document that will be updated and kept available to all Weldon School instructors. Your comments and suggestions are welcome. Finally, a quick update on the IUPUI integration. Our BME unit in Indy is pretty much spared from office moving for their faculty. There will not be pending moves of our offices there, except for a few who have received administrative appointments. Joey Wallace, appointed as the Site Director, is helping us. Many thanks to him providing valuable assistance to all of us navigating these final steps of this integration process. UPCOMING IMPORTANT DATES Week of April 29 Mon., April 29: BME PhD Preliminary Exam Announcement for Thejas Vishnu Ramesh (J. Rispoli and V. Rayz, advisors). Everyone is invited to attend the public presentation beginning at 2:00 PM in MJIS 2001 and via Zoom. Research title: Conductive fabric based wearable coil for cervical spine and carotid arteries MRI at 3T. Mon., April 29: Center for Diabetes and Metabolic Diseases Enrichment Seminar Series, 12:00 noon, R4-101 (Indianapolis) and via Zoom. Sangeeta Dhawan, PhD, Associate Professor of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA will present "Learning the Epigenetic Secrets of Islet Development to Understand Beta Cell Failure in Diabetes. This seminar is sponsored by the Center for Diabetes and Metabolic Diseases, IU School of Medicine. Zoom link: https://iu.zoom.us/j/87501979533#success<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fiu.zoom.u…> Tues., April 30: Neil Armstrong Distinguished Visiting Professors, 3:00 p.m., WALC 1018. Dr. Ronald Latanision, Senior Fellow, Exponent, Inc. and Neil Armstrong Distinguished Visiting Professor, School of Industrial Engineering, will present "The Evolution of the Materials Genome Initiative." There will be a reception following the seminar, from 4:00-4:30 p.m. More information at https://engineering.purdue.edu/NADVP?utm_source=delivra&utm_medium=email&ut… Wed., May 1: Weldon School 2024-2025 GTA Nominations Due. We are excited to begin our recruitment of Graduate Teaching Assistants (GTAs) for the upcoming 2024-25 academic year. The process involves faculty nominations via the survey link below for your graduate students. Please complete the survey by May 1st for consideration of your student(s) for a GTA role and funding: https://purdue.ca1.qualtrics.com/jfe/form/SV_3wSzp9BFQyoeW8K<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Assignments will be made based on overall needs for each course and experience/performance of each candidate. Following the faculty nomination process, assignments will be made in early summer and notifications of placements are expected to be sent in June. If you have any questions, please feel free to contact me (aboelzahab(a)purdue.edu<mailto:aboelzahab@purdue.edu>). Additionally, if you have any international students who have not yet taken the OEPT (Oral English Proficiency Test), please have them reach out to me to schedule this as slots remain available. Thurs., May 2: BME Master's Defense Announcement for Adalyn Meeks (Craig Goergen, advisor). Everyone is invited to attend the public presentation beginning at 2:00 PM EST in MJIS 2001 and via Zoom. Title: High-Frequency Murine Ultrasound of Microrobot Drug Delivery Systems and Cardiac Effects of Hypertension During Pregnancy. Thurs., May 2: Neil Armstrong Distinguished Visiting Professors, 2:40-3:20 p.m., STEW 218. Professor Mordechai Segev, Robert J. Shillman Distinguished Professor of Physics and Electrical Engineering, Technion, Israel, and Neil Armstrong Distinguished Visiting Professor, The Elmore Family School of Electrical and Computer Engineering, Purdue will present "Light-Matter Interactions in Photonic Time-Crystals" as part of the 4th Annual Quantum Summer School, The Quantum Science Center, hosted by Purdue. For more information: https://engineering.purdue.edu/NADVP?utm_source=delivra&utm_medium=email&ut… MJIS END OF SEMESTER ALERTS/REMINDERS Just a quick reminder of a few MJIS policies as we approach the chaos that is the end of the semester. (1) Do not give access (e.g., open a door, prop a door) to anyone you do not know into the secure lab block or any office or meeting room. If there is someone you do not recognize, feel free to call/text Susan Hardy and let her know. Vendors or service personnel should always be invited and escorted by a BME staff or faculty member, and should not be in the building after (or before) normal working hours. Purdue service personnel should always identify themselves and their purpose for being in MJIS. (2) Do not leave office doors unlocked or personal items (backpacks, purses, laptops) unattended. Unfortunately, this is the time of year when individuals come on to our campus to take advantage of distractions associated with the semester ending. We have had personal items stolen in the past. Don't become a victim! GRADING DEADLINES Dear BME faculty, It's crazy to believe the end of the Spring term is just around the corner and final grading opens THIS WEEK. This is the perfect time to ensure your web certifications are current so you don't get stuck during a deadline. FERPA, GLBA, Protecting SSNs, and Data Handling all must be current at the time of grade entry to prevent any roadblocks. Full Term (meets January 8 through May 4) and Second Eight Weeks (meets March 4 through May 4) Grade entry begins at 8 a.m. April 22 and ends at 5 p.m. May 7. Grading Instructions INB or myPurdue grading instructions are here: https://www.purdue.edu/registrar/faculty/gradingPWL-grade-entry-update.html<https://www.purdue.edu/registrar/faculty/grading/PWL-grade-entry-update.html>. The full grading policy can be found here: https://catalog.purdue.edu/content.php?catoid=16&navoid=19719#grades-and-gr… Grading questions: Contact the Office of the Registrar by calling (765) 494-6165 or sending an e-mail to registrar(a)purdue.edu<mailto:registrar@purdue.edu> Upcoming important deadlines and information Tues., May 7: BME PhD Defense Announcement for Vidhya Vijayakrishnan Nair (Yunjie Tong, advisor). Everyone is invited to attend the public presentation beginning at 9:00 AM in MJIS 2001 and via Zoom. Research title: Human Cerebrospinal Fluid Movement across Wake and Sleep States - A Multimodal Imaging Study Wed., May 8: BME PhD Defense Announcement for Yilun Li (Fang Huang, advisor). Everyone is invited to attend the public presentation beginning at 10:00AM EST in FLEX B038 or via Zoom. Title: A user-centric cloud computation platform for super-resolution imaging reconstruction. Thurs., May 9: IBSC-BME Preliminary Exam Announcement for Eric J. Tan (Tamara Kinzer-Ursem, advisor), 2:30 p.m., MJIS 2001. This preliminary exam is open only to those who have signed the Lilly NDA. Title: Developing ultrasensitive point-of-care detection of hyper-phosphorylated tau in patients with preclinical Alzheimer's disease. Committee: Tamara L. Kinzer-Ursem, Chair; Jacqueline Linnes; Jean-Christophe Rochet; Scott C. Bolton Fri., May 10: Deadline for Registration for 2024 Hitchhiker's Guide to the Biomolecular Galaxy, to be held Thursday, May 23-Friday, May 24 in Armstrong Hall. ! Please register using this link<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fqualtrics…>. If you would like to present an oral presentation or poster, please submit an abstract when registering. Awards will be given to the Top 3 posters and oral presentations, with a People's Choice award at the end of the second day. Thurs., May 23-Fri., May 24: 2024 Hitchhiker's Guide to the Biomolecular Galaxy, Armstrong Hall. Registration is officially open for the 2024 Hitchhiker's Guide to the Biomolecular Galaxy! Please register using this link<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fqualtrics…>. Hitchhiker's Guide to the Biomolecular Galaxy Symposium brings together undergraduate students, graduate students, post-doctorates, and faculty throughout the Midwest who are all striving to share and gain more insight into various biophysical approaches. Registration is completely free with breakfast, lunch, coffee, and snacks provided both days. The symposium will include a keynote address given by Dr. Jin Zhang from the University of California San Diego. Dr. Zhang's research lab developed a series of molecular tools and fluorescence imaging technologies to understand the spatiotemporal regulation of cell signaling. <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjinzhangl…> Fri., June 7: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor, Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Resources and further information Mon., April 29: BME PhD Preliminary Exam Announcement for Thejas Vishnu Ramesh (J. Rispoli and V. Rayz, advisors). Everyone is invited to attend the public presentation beginning at 2:00 PM in MJIS 2001. Research title: Conductive fabric based wearable coil for cervical spine and carotid arteries MRI at 3T. Thesis committee members: Dr. Joseph Rispoli (co-chair), Dr. Vitaliy Rayz (co-chair), Dr. Craig Goergen (committee member) and Dr. Uzay Emir (committee member). Abstract: MRI is a non-ionizing, non-invasive imaging modality that provides superior soft tissue contrast. Radiofrequency (RF) coils are the antennas through which images are obtained in MRI. Volume coils provide a homogeneous field around the region of interest (ROI) while surface coils help obtain the maximum signal-to-noise ratio (SNR) for high resolution images. Receive arrays are made of multiple surface coils for concomitant acquisition of spatial information from the anatomy, thus enabling parallel imaging. MR angiography (MRA) techniques such as time-of-flight (TOF) MRI and phase contrast (PC) angiography take advantage of parallel imaging to visualize the vasculature and understand the underlying hemodynamics that can lead to cardiovascular diseases, especially in the carotid arteries. A rigid whole neck array that contains coils that extend to the cervical spine are often used to image the carotid arteries. However, the rigid neck array lacks adaptability to varying neck sizes, thus limiting the SNR. Wearable coils that tightly conform around the anatomy of interest developed using techniques such as screen printing, conductive elastomer, and conductive thread reduce coil setup time while ensuring maximum SNR in the final image. However, current wearable coil fabrication methods require specialized manufacturing practices, which render coil development an expensive process. Therefore, a wearable array developed using commercially available conductive fabric is proposed for simultaneous bilateral carotid arteries and cervical spine imaging at 3T. The conductive fabric method eliminates specialized manufacturing needs for developing wearable coils, thus enhancing RF coil accessibility without compromising patient comfort and image quality. Zoom link: https://purdue-edu.zoom.us/j/92041421380?pwd=SGRQaVcvS3MrdEduSHdIazBSNFVkZz…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Thurs., May 2: BME Master's Defense Announcement for Adalyn Meeks (Craig Goergen, advisor). Everyone is invited to attend the public presentation beginning at 2:00 PM EST in MJIS 2001 and via Zoom. Title: High-Frequency Murine Ultrasound of Microrobot Drug Delivery Systems and Cardiac Effects of Hypertension During Pregnancy. Committee: Dr. Craig Goergen (Chair), Dr. David Cappelleri, Dr. Luis Solorio Abstract: Murine, or small rodent, models can provide valuable and translatable insights into human pathophysiology. Specifically, we are looking to combine murine models and high-frequency ultrasound to non-invasively investigate microrobot drug delivery systems and cardiac remodeling due to the combination of pregnancy and hypertension. Currently, we are looking at the applications of microrobots within the colon to provide targeted treatment for patients suffering with inflammatory bowel disease (IBD). IBD is an overarching term encompassing chronic inflammation of the digestive tract tissue. The standard treatment of IBD includes oral and injectable treatments depending on disease severity. The drawbacks of these therapeutics are the associated systemic toxicity, non-specific treatment allocation, and degradation of the treatment in proximal portions of the gastrointestinal (GI) system. The goal of this research is to use an external magnetic torque to cause the microrobots to tumble to targeted areas of inflammation and release a drug payload. Retroactive locomotion of these microrobots can avoid degradation in the proximal GI tract. Therefore, these microrobots need a smaller drug payload to provide the same efficacy as traditional treatments. Chronic hypertension affects approximately 1 in 20 pregnancies and its prevalence in pregnancies continues to increase. The maternal cardiovascular system goes through dynamic changes during pregnancy to meet the demands of perfusing the gestation, especially during the exponential growth seen later in pregnancy. Studies with female C57BL/6J mice demonstrate comparable cardiovascular changes during pregnancy to those observed in humans. Additionally, a study using rats showed the cardioprotective properties of pregnancy against angiotensin II induced fibrosis. The objective of this study is to characterize non-invasive cardiac remodeling in a small animal model of hypertensive disorders in pregnancy. We used a combination of ultrasound imaging and noninvasive blood pressure measurements to longitudinally monitor the physiological adaptations that occur during pregnancy with superimposed hypertension. Zoom link: https://purdue.edu.zoom.us/j/97871973409?pwd=ZndVVmJ6Z3JUM0FuNU40aFF6elA4QT…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ed…> Meeting ID: 978 7197 3409 Passcode: 091537 Tues., May 7: BME PhD Defense Announcement for Vidhya Vijayakrishnan Nair (Yunjie Tong, advisor). Everyone is invited to attend the public presentation beginning at 9:00 AM in MJIS 2001 and via Zoom. Research title: Human Cerebrospinal Fluid Movement across Wake and Sleep States - A Multimodal Imaging Study. Thesis Committee Members: Dr. Yunjie Tong (Chair), Dr. A.J. Schwichtenberg, Dr. Vitaliy L. Rayz, Dr. Yu-Chien Wu. Abstract: The movement of Cerebrospinal Fluid (CSF) within the brain's ventricles and the subarachnoid spaces of both the cranium and spine is crucial for the health and functioning of the central nervous system. Recent research has emphasized CSF movement's importance in metabolic waste clearance and its effect on the pathophysiology of neurodegenerative and neurodevelopmental disorders. Additionally, CSF movement is significantly enhanced during Non-rapid eye movement (NREM) sleep. Despite the critical role of CSF in maintaining brain health, a comprehensive understanding of the mechanisms driving its movement across different states of wakefulness and sleep is lacking. In this work, multimodal imaging was utilized to simultaneously monitor CSF movement and brain hemodynamics via functional Magnetic Resonance Imaging (MRI), neural activity through Electroencephalography (EEG), and non-neuronal systemic physiology via peripheral functional Near-Infrared Spectroscopy (fNIRS). Our findings reveal that CSF movement is influenced by multiple physiological forces concurrently. During wakefulness, both low-frequency vasomotion and respiration interact to regulate CSF movement. Furthermore, systemic physiological changes significantly impact CSF movement during light NREM sleep, even in the presence of autonomic neural activity. Notably, during deep NREM3 sleep, CSF movement magnitude increases independent of the magnitude of brain hemodynamics, suggesting a decrease in impedance to CSF movement and an enhanced exchange between CSF and interstitial fluid (ISF) in the brain. Building on these observations, significant enhancement of CSF movement was also achieved via simple respiratory interventions, thereby demonstrating their potential to be used as clinical protocols across pathologies characterized by reduced CSF movement. Zoom Meeting Link: https://purdue-edu.zoom.us/j/95341354792?pwd=L2ZBTmJYUEVDRXhDTm03cU9JYlBOUT…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Meeting ID: 953 4135 4792 Passcode: 741481 Wed., May 8: BME PhD Defense Announcement for Yilun Li (Fang Huang, advisor). Everyone is invited to attend the public presentation beginning at 10:00AM EST in FLEX B038 or via Zoom. Title: A user-centric cloud computation platform for super-resolution imaging reconstruction. Committee Members: FANG HUANG (Chair), DANIEL M. SUTER, STEVEN T. WERELEY, XIAOHUI C. SONG Abstract: Single-molecule localization microscopy (SMLM) leverages the detection and localization of individual fluorescently tagged molecules to visualize cellular and tissue samples at a nanometer resolution. The reconstruction of a super-resolution image via SMLM, however, involves intricate algorithms and large scale computation that may require hours to achieve a single high-quality 3D image. Additionally, the image generation process calls for specialized expertise and resources, such as knowledge of image processing and massively parallel computing. To address these challenges, we are developing an integrated cloud-based SMLM suite named "cloud-SMLM". This suite combines key algorithms from each stage of single molecule analysis, integrating with high levels of parallelization. Deployable on cloud-based computational services like Amazon Web Service (AWS), cloud-SMLM interacts with its users through a dedicated, easy-to-use drag-and-drop webpage. This design eliminates the prerequisite for hardware such as GPU and reduces the knowledge barrier for users of single molecule nanoscopy. Accessible from any web-browser equipped device, it enables users to initiate and modify data reconstruction. Furthermore, it provides visualization and data mining tools for users to explore the reconstructed three-dimensional ultra-high-resolution cellular and tissue volumes. We expect that this project will democratize existing and new single molecule super-resolution imaging capacities by integrating them into computational pipelines for a wide range of biological model systems. We believe that the success of cloud-SMLM will represent a significant step towards unlocking the full potential of ultra-high resolution optical imaging in biological and biomedical research. Join Zoom Meeting https://purdue-edu.zoom.us/j/91595672410?pwd=c2lyTzVSTXpuTTA1R3o2aWR4Y1l2UT…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Meeting ID: 915 9567 2410 Passcode: 730694 Thurs., May 23-Fri., May 24: 2024 Hitchhiker's Guide to the Biomolecular Galaxy, Armstrong Hall. Registration is officially open for the 2024 Hitchhiker's Guide to the Biomolecular Galaxy! Please register using this link<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fqualtrics…>. Hitchhiker's Guide to the Biomolecular Galaxy Symposium brings together undergraduate students, graduate students, post-doctorates, and faculty throughout the Midwest who are all striving to share and gain more insight into various biophysical approaches. Registration is completely free with breakfast, lunch, coffee, and snacks provided both days. The symposium will include a keynote address given by Dr. Jin Zhang from the University of California San Diego. Dr. Zhang's research lab developed a series of molecular tools and fluorescence imaging technologies to understand the spatiotemporal regulation of cell signaling. <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjinzhangl…> We will be hosting pre-symposium events on Wednesday, May 22nd 2024. Our pre-symposium events are focused on advancing careers with professional development and implementing diversity and inclusion in our field, along with social and networking opportunities with other researchers at Purdue and the Midwest! Each day of the symposium will consist of seminar style lectures where graduate students, postdoctoral fellows, undergraduates, faculty, and visitors can share their work. If you would like to present an oral presentation, please submit an abstract when registering by May 10, 2024. The first day will also include a two-hour workshop session with four technical workshops: * Easy (and accurate) structure modeling & validation on web server for cryo-EM * An introduction to 3D Molecular movies (PyMOL, Chimera, Blender/Maya) * Figure Making and Ethics * Quantitative proteomics When registering for the symposium, participants will rank the order of workshops they are interested in (1 being the most likely). Participants will be placed in each workshop on a first-come, first- serve basis upon registering until the workshop reaches maximum capacity. On the second day of the symposium, we will be hosting a two-hour poster session. If you would like to participate in this poster session, please submit an abstract by May 10, 2024, when registering for the symposium! Awards will be given to the Top 3 posters and oral presentations, with a People's Choice award at the end of the second day. Hope to see you all there! On behalf of the 2024 organizing committee: Co-Chair, Kadidia Samassekou (Department of Chemistry) Co-Chair, Vaani Ohri (Department of Biological Sciences) Kadir Ozcan (Department of Biological Sciences) Hanna Bovill (Department of Chemistry) Ketaki Mahurkar (PULSe/Department of Chemistry) Michelle Bush (Department of Biological Sciences) Ryan Peters (Department of Biological Sciences) Hunain Janjua (PULSe/Department of Biological Sciences) Faculty Mentor: Dr. Lauren Ann Metskas (Department of Biological Sciences and Chemistry) Postdoctoral Fellow Opportunity - IUSM Emergency Medicine The laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include: (1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally. For additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Findiana.p…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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BME Master's Defense Announcement for Adalyn Meeks (Craig Goergen, advisor)
by May, Sandra M 26 Apr '24

26 Apr '24

BME Master's Defense Announcement for Adalyn Meeks (Craig Goergen, advisor) Everyone is invited to attend the public presentation beginning at 2:00 PM EST. Title: High-Frequency Murine Ultrasound of Microrobot Drug Delivery Systems and Cardiac Effects of Hypertension During Pregnancy Date: 05/02/2024 Time: 2:00PM EST Room: MJIS 2001 Zoom link: https://purdue.edu.zoom.us/j/97871973409?pwd=ZndVVmJ6Z3JUM0FuNU40aFF6elA4QT…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ed…> Meeting ID: 978 7197 3409 Passcode: 091537 Committee: Dr. Craig Goergen (Chair) Dr. David Cappelleri Dr. Luis Solorio Abstract: Murine, or small rodent, models can provide valuable and translatable insights into human pathophysiology. Specifically, we are looking to combine murine models and high-frequency ultrasound to non-invasively investigate microrobot drug delivery systems and cardiac remodeling due to the combination of pregnancy and hypertension. Currently, we are looking at the applications of microrobots within the colon to provide targeted treatment for patients suffering with inflammatory bowel disease (IBD). IBD is an overarching term encompassing chronic inflammation of the digestive tract tissue. The standard treatment of IBD includes oral and injectable treatments depending on disease severity. The drawbacks of these therapeutics are the associated systemic toxicity, non-specific treatment allocation, and degradation of the treatment in proximal portions of the gastrointestinal (GI) system. The goal of this research is to use an external magnetic torque to cause the microrobots to tumble to targeted areas of inflammation and release a drug payload. Retroactive locomotion of these microrobots can avoid degradation in the proximal GI tract. Therefore, these microrobots need a smaller drug payload to provide the same efficacy as traditional treatments. Chronic hypertension affects approximately 1 in 20 pregnancies and its prevalence in pregnancies continues to increase. The maternal cardiovascular system goes through dynamic changes during pregnancy to meet the demands of perfusing the gestation, especially during the exponential growth seen later in pregnancy. Studies with female C57BL/6J mice demonstrate comparable cardiovascular changes during pregnancy to those observed in humans. Additionally, a study using rats showed the cardioprotective properties of pregnancy against angiotensin II induced fibrosis. The objective of this study is to characterize non-invasive cardiac remodeling in a small animal model of hypertensive disorders in pregnancy. We used a combination of ultrasound imaging and noninvasive blood pressure measurements to longitudinally monitor the physiological adaptations that occur during pregnancy with superimposed hypertension.

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BME PhD Defense Announcement for Yilun Li (Fang Huang, advisor)
by May, Sandra M 26 Apr '24

26 Apr '24

BME PhD Defense Announcement for Yilun Li (Fang Huang, advisor) Everyone is invited to attend the public presentation beginning at 10:00AM EST. Title: A user-centric cloud computation platform for super-resolution imaging reconstruction Date: May 8, 2024 Time: 10:00AM EST Location: FLEX LAB B038 or Join Zoom Meeting https://purdue-edu.zoom.us/j/91595672410?pwd=c2lyTzVSTXpuTTA1R3o2aWR4Y1l2UT…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Meeting ID: 915 9567 2410 Passcode: 730694 Committee Members: FANG HUANG (Chair), DANIEL M. SUTER, STEVEN T. WERELEY, XIAOHUI C. SONG Abstract: Single-molecule localization microscopy (SMLM) leverages the detection and localization of individual fluorescently tagged molecules to visualize cellular and tissue samples at a nanometer resolution. The reconstruction of a super-resolution image via SMLM, however, involves intricate algorithms and large scale computation that may require hours to achieve a single high-quality 3D image. Additionally, the image generation process calls for specialized expertise and resources, such as knowledge of image processing and massively parallel computing. To address these challenges, we are developing an integrated cloud-based SMLM suite named "cloud-SMLM". This suite combines key algorithms from each stage of single molecule analysis, integrating with high levels of parallelization. Deployable on cloud-based computational services like Amazon Web Service (AWS), cloud-SMLM interacts with its users through a dedicated, easy-to-use drag-and-drop webpage. This design eliminates the prerequisite for hardware such as GPU and reduces the knowledge barrier for users of single molecule nanoscopy. Accessible from any web-browser equipped device, it enables users to initiate and modify data reconstruction. Furthermore, it provides visualization and data mining tools for users to explore the reconstructed three-dimensional ultra-high-resolution cellular and tissue volumes. We expect that this project will democratize existing and new single molecule super-resolution imaging capacities by integrating them into computational pipelines for a wide range of biological model systems. We believe that the success of cloud-SMLM will represent a significant step towards unlocking the full potential of ultra-high resolution optical imaging in biological and biomedical research.

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Weldon Graduate Program Announcements April 24th, 2024
by Siemers, Tammy R 24 Apr '24

24 Apr '24

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements April 24th, 2024 * Career and Internship Opportunities * 2024 Purdue Systems Collaboratory Summit (PSC) * Graduate Professional Development Newsletter (April 19) * Registration OPEN for the 2024 Hitchhiker's Guide to the Biomolecular Galaxy * FAA National Air Grant Fellowship Opportunity * Job Vacancy for Grad Students: Become a C.A.V.E. Academic Mentor! * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Clinical Trials Intern, SRI<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> Postdoctoral Positions * NPA Website: https://careers.nationalpostdoc.org/jobs/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.n…> Full Time Positions * Associate Principal Scientist, Biologics Process Development, Merck<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Pharmaceutical Project Engineers, VTI Life Sciences<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Biomedical Engineer, Contract, MedLance<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Manufacturing Associate I or 2, Capricor<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Biomedical Engineer/Clinical Engineer, Blue Water Thinking<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Purdue Start-up Job Board<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurduefou…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.a…>-Association for Clinical and Translational Science * Academic Careers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Facademicc…> * Doc Jobs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.docjo…>-Jobs beyond traditional clinical and academic roles 2024 Purdue Systems Collaboratory Summit (PSC) See attached [cid:image002.jpg@01DA9666.EC64A3A0] Graduate Professional Development Newsletter (April 19) Graduate Professional Development Newsletter (April 19)<https://mailimages.purdue.edu/vo/?FileID=65a0dc4f-6f6b-4fe9-833d-82a700f16c…> Registration OPEN for the 2024 Hitchhiker's Guide to the Biomolecular Galaxy [cid:image003.png@01DA9666.EC64A3A0] Registration is officially open for the 2024 Hitchhiker's Guide to the Biomolecular Galaxy! Please register using this link<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fqualtrics…>. Hitchhiker's Guide to the Biomolecular Galaxy Symposium brings together undergraduate students, graduate students, post-doctorates, and faculty throughout the Midwest who are all striving to share and gain more insight into various biophysical approaches. The Hitchhiker's symposium will be held on May 23-24, 2024, in Armstrong at Purdue University. Registration is completely free with breakfast, lunch, coffee, and snacks provided both days. The symposium will include a keynote address given by Dr. Jin Zhang from the University of California San Diego. Dr. Zhang's research contributions were recognized by numerous awards. Her lab developed a series of molecular tools and fluorescence imaging technologies to understand the spatiotemporal regulation of cell signaling. <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjinzhangl…> Dr. Zhang's lab website is provided here: https://jinzhanglab.ucsd.edu/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjinzhangl…> We will be hosting pre-symposium events on Wednesday, May 22nd 2024. Our pre-symposium events are focused on advancing careers with professional development and implementing diversity and inclusion in our field, along with social and networking opportunities with other researchers at Purdue and the Midwest! Each day of the symposium will consist of seminar style lectures where graduate students, postdoctoral fellows, undergraduates, faculty, and visitors can share their work. If you would like to present an oral presentation, please submit an abstract when registering by May 10, 2024. The first day will also include a two-hour workshop session with four technical workshops: * Easy (and accurate) structure modeling & validation on web server for cryo-EM * An introduction to 3D Molecular movies (PyMOL, Chimera, Blender/Maya) * Figure Making and Ethics * Quantitative proteomics When registering for the symposium, participants will rank the order of workshops they are interested in (1 being the most likely). Participants will be placed in each workshop on a first-come, first- serve basis upon registering until the workshop reaches maximum capacity. On the second day of the symposium, we will be hosting a two-hour poster session. If you would like to participate in this poster session, please submit an abstract by May 10, 2024, when registering for the symposium! Awards will be given to the Top 3 posters and oral presentations, with a People's Choice award at the end of the second day. Hope to see you all there! On behalf of the 2024 organizing committee: Co-Chair, Kadidia Samassekou (Department of Chemistry) Co-Chair, Vaani Ohri (Department of Biological Sciences) Kadir Ozcan (Department of Biological Sciences) Hanna Bovill (Department of Chemistry) Ketaki Mahurkar (PULSe/Department of Chemistry) Michelle Bush (Department of Biological Sciences) Ryan Peters (Department of Biological Sciences) Hunain Janjua (PULSe/Department of Biological Sciences) Faculty Mentor: Dr. Lauren Ann Metskas (Department of Biological Sciences and Chemistry) FAA National Air Grant Fellowship Opportunity See attached I want to share with the ASCENT community information about FAA's Samya Rose Stumo National Air Grant Fellowship program. About the Program: Each Fellow will spend a year with a Congressional office that has jurisdiction over the FAA. A fellow may serve as an expert liaison and researcher for a Congressional committee and may participate in FAA program activities to further develop their knowledge and skills. The program is designed to offer graduate students a hands-on experience at navigating public policy issues related to their field of expertise. FAA seeks participants in fields related to aerospace. A flyer is attached with more information. Note that FAA hired three National Air Grant Fellows from the 2023 cohort. FELLOWSHIP AWARD INFORMATION The Samya Rose Stumo National Air Grant Fellowship program anticipates supporting multiple fellowships each calendar year. * The application period for the 2025 cohort is December 1, 2024 through January 31, 2025. * Length: 12-month, non-renewable fellowship assignment * Start date: Late June/July of 2025 More details are available at https://www.faa.gov/nagf<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.faa.g…> Explore Postdoc Opportunities: Virtual Seattle DROP Recruitment Event May 7th See attached Explore engaging postdoc opportunities in Seattle, WA! Join us on May 7th from 8am-2:30pm PST for Seattle DROP (Diverse Research Opportunities for Postdocs), a virtual postdoc recruitment event for biomedical researchers seeking the next step in your scientific journey. This event is a collaboration between the Fred Hutchinson Cancer Center,<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.fredh…> University of Washington<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgrad.uw.e…> and Seattle Children's Research Institute<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.seatt…>. Enjoy lunch on us via a delivery voucher for the first 250 registrants within the US! Individuals from groups who are underrepresented in biomedical research are especially encouraged to attend. Open to all who register. Register here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.cance…> Agenda includes: * Connect with experts in a NIH T32 PI research showcase * Engage with current postdocs about their research, our vibrant scientific community and life in Seattle * Enjoy a stimulating conversation about "The Importance of Choosing the Right Mentor," with Dr. Harmit Malik, Dr. Sharona Gordon and Dr. Beth Lawlor * Learn how our institutions empower all scientists to succeed by "Celebrating Our Identities in the Pacific Northwest," spotlighting DEI initiatives and affinity groups * Interact with representatives at each institution and learn more about resources at institution-specific break-out sessions Register here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.cance…> Questions? Please contact seattledrop(a)cancerconsortium.org<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.cance…> [A poster for Seattle DROP May 7, 2024 Description automatically generated]<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.cance…> Job Vacancy for Grad Students: Become a C.A.V.E. Academic Mentor! See attached My name is Greg Ricketts, and I am a graduate assistant at the Center for Academic Vision and Enrichment (C.A.V.E.). Every semester, we use academic mentors to assist our student-athletes in the C.A.V.E. These mentors assist and engage with student-athletes in understanding assignments, proofreading, test preparation, organization, and time management. We are looking for graduate students to help this upcoming summer and fall 2024. More information on the application process and the C.A.V.E. is attached below. This position is compensated but does not provide graduate funding. Interested applicants can apply here: https://careers.purdue.edu/default/job/C_A_V_E-Mentor-Student/3035-en_US Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. April 24th Plaksha University Information Session & Faculty Opportunties (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) April 24th & 25th Cornerstone Autism Center Virtual Job Fair (CCO<https://www.cco.purdue.edu/Calendar/Event/461>) April 25th Deadline to register for Purdue Systems Collaboratory Summit @ Stewart Center (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>) April 26th Deadline to submit pre-proposal for Chorafas Foundation Award (COE<https://engineering.purdue.edu/Engr/Academics/Graduate/Events/chorafas-foun…>) April 26th Deadline for Schmidt Science Postdoc Fellowship Nominations (More Info<file:///U:/Personal/Downloads/Schmidt%2520Science%2520Fellow%2520Information.pdf>) April 26th - May 3rd NICHES 5th Annual War of the Weeds (CCO<https://www.cco.purdue.edu/Calendar/Event/450>) April 29th Fellowship Office Hour for Grad Students and Postdocs (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 1st OIGP Spring Reception, 9:30 am - 3:30 pm PMU Ballrooms & East Faculty Lounge May 8th NIH Fellowship F31 Information Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 9th NIH F32 and K99/R00 Info Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 9th Graduate Gateway: Caps Off Celebration 2024 for 2024 graduates (CCO<https://www.cco.purdue.edu/Calendar/Event/458>) May 11th Graduation Commencement Reception for Family & Friends (MJIS Atrium 9 - 11:30a) May 14th How to Find and Prepare for Fellowship Applications (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 14th - 17th 17th Annual NIH Virtual Career Symposium (Register Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwhova.com…>) May 15th Fellowship Office Hour for Grad Students and Postdocs (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 16th Postdoc Houston Virtual Recruitment Event (Register Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.postd…>) May 16th Business Meal Etiquette (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 17th Applications due for Rising Stars in Engineering in Health Workshop (Apply Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.bu.ed…>) May 21st Research with Scite.ai (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 22nd Hitchhiker's Guide to the Biomolecular Galaxy pre-symposium events (Info Here<https://hitchhikers.science.purdue.edu/2024/index.html>) May 22nd Success over Stress (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 23rd NSF Fellowship Help Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 23rd & 24th Hitchhiker's Guide to the Biomolecular Galaxy Symposium (Info Here<https://hitchhikers.science.purdue.edu/2024/index.html>) June 4th Publishing a Scientific Paper (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 11th Citation Management with Zotero (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 13th Business Meal Etiquette (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 14th NSF Fellowship Help Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 17th NSF Personal Statement Writing Workshop (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 18th Fellowship Office Hour for Grad Students and Postdcos (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 19th Research with Scite.ai (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 20th RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 21st NSF Fellowship Help Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 24th Conference Paper Writing and Presenting: Strategies for Success (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) July 16th Citation Management with Zotero (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) July 17th Business Meal Etiquette (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) July 19th RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education BME Students (ONLY): Schedule appointments with me via BoilerConnect here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>. Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [cid:image005.png@01DA9666.EC64A3A0]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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[Bmeroundtable-list] BME Weekly Roundtable - April 22, 2024
by Gelfand, Johanna K 22 Apr '24

22 Apr '24

[cid:image003.png@01DA94AC.3103CF70] BME WEEKLY ROUNDTABLE April 22, 2024 LAST WEEK OF CLASSES! INTERIM HEAD'S NOTE This week is the quiet period. It occurs during the last Monday through Saturday of the instruction period preceding the final examination period. This is a friendly reminder. Please follow the Quiet Period policies, https://www.purdue.edu/innovativelearning/teaching/module/policies/. It is important to keep a close watch on students' mental health. Quiet period means we are coming to the end of the semester. This is also the awards season and season for giving. Purdue Day of Giving is this Wednesday, April 24. Here is a list of the faculty and student awards I have been made aware of. I plan to do it in the next couple of Roundtables as well. Please let me know if I have missed any. I want to highlight all the accomplishments our people have made this year (not in any particular order). Scott Malloy and Victoria Sinfield received the Magoon Teaching Award, Seokkyoon Hong received the BME Outstanding Graduate Research Award, Juan Mesa received the BME Outstanding Service Scholarship, Aditya Shangavi, Emilee Madsen, Ankit Shah, and Folk Narongrit received Lamp Scholarships for Excellence in Teaching in Biomedical Engineering, Elnaz Ghajar-Rahimi received the Bilsland Dissertation Award, and Timothy (Brock) Beauclair received the Teaching Academy Graduate Teaching Award. Dr. Tamara Kinzer-Ursem received the Dean H.T. Yang Faculty Excellence Award for Leadership in Service. Dr. Jacqueline Linnes received the Faculty Excellence Award for Graduate Student Mentorship. We had our last meeting of the working group on teaching. We came back to the focus we started, i.e., teaching assignments. We made some decisions on getting additional information from the faculty that is expected to facilitate the assignment. An email was sent to you this morning by Jo on behalf of Vitaliy. For the end-of-the semester mini-retreat in Lafayette County Club from 2 to 5 pm on 5/3 (Friday), we have received overwhelming interest. We will have a big party with more than 40 people. Jo and Rhonda have developed an exciting agenda and prepared some fun activities. UPCOMING IMPORTANT DATES Week of April 22 Mon., April 22: Center for Diabetes and Metabolic Diseases Research Seminar Series, 12:00 noon, R4-101 (Indianapolis) and via Zoom. Schafer Boeder, MD, Assistant Professor of Medicine, University of California, San Diego Division of Endocrinology and Metabolism, will speak on "Combination Insulin Adjunctive Therapy to Address Unmet Needs in Type 1 Diabetes." Zoom link: https://iu.zoom.us/j/87501979533#success<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fiu.zoom.u…> This seminar series is sponsored by the Indiana University School of Medicine and the Center for Diabetes and Metabolic Diseases. Wed., April 24: PhD Preliminary Exam Announcement for Rachel Stingel (R. Shi, advisor). Everyone is invited to attend the public presentation beginning at 9:00 AM EDT in MJIS 2001 and via Zoom. Title: Acrolein-mediated excitotoxicity following spinal cord injury Wed., April 24: BME Distinguished Research Seminar Series, 9:30 a.m., MRGN 121 and via Zoom. Stacey D. Finley, PhD, Nichold A. and Thuan Q. Pham Professor, University of Southern California will present "Exploring the tumor ecosystem: Modeling across scales." Wed., April 24: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131 and via Zoom. George Smith, PhD, Professor and Vice Chair, Department of Neural Sciences; Interim Director, Shriner's Children Hospitals Pediatric Research Center; Professor of Bioengineering, Lewis Katz School of Medicine at Temple University will present "Rehabilitation Induces Adaptation of Motor Control Pathways after SCI." Thurs., April 25: Seminars in Hearing Research, 12:00 p.m., Nelson Hall Room 1215. Elle O'Brien, PhD, University of Michigan, will present "How will generative AI change scientific software?" Thurs., April 25: BMS 692/CPB 697 Graduate Seminar, 12:30 p.m., LYNN 1136. Four graduate students will be presenting their research at the BMS 692/CPB 697 graduate course, including one of our very own BME graduate students, Tuba Marjan. Here is the complete listing: "Presumptive Localized Histiocytic Sarcoma in a Dog" by Camila Benaduce E. Mello - Resident, CPB; "Age-Related Differences in Mouse Brain Lipidome" by Punyatoya Panda - Graduate Student, CPB; "Hydrogel Platform with Tunable Biochemical Properties to Study Cell-Matrix Interactions" by Tuba Marjan - Graduate Student, BME; and "Advancing Prey-Predator Models with AI-Enhanced Simulations" by Marwa Ali - Graduate Student, CPB. MJIS END OF SEMESTER ALERTS/REMINDERS Just a quick reminder of a few MJIS policies as we approach the chaos that is the end of the semester. (1) Do not give access (e.g., open a door, prop a door) to anyone you do not know into the secure lab block or any office or meeting room. If there is someone you do not recognize, feel free to call/text Susan Hardy and let her know. Vendors or service personnel should always be invited and escorted by a BME staff or faculty member, and should not be in the building after (or before) normal working hours. Purdue service personnel should always identify themselves and their purpose for being in MJIS. (2) Do not leave office doors unlocked or personal items (backpacks, purses, laptops) unattended. Unfortunately, this is the time of year when individuals come on to our campus to take advantage of distractions associated with the semester ending. We have had personal items stolen in the past. Don't become a victim! GRADING DEADLINES Dear BME faculty, It's crazy to believe the end of the Spring term is just around the corner and final grading opens THIS WEEK. This is the perfect time to ensure your web certifications are current so you don't get stuck during a deadline. FERPA, GLBA, Protecting SSNs, and Data Handling all must be current at the time of grade entry to prevent any roadblocks. Full Term (meets January 8 through May 4) and Second Eight Weeks (meets March 4 through May 4) Grade entry begins at 8 a.m. April 22 and ends at 5 p.m. May 7. Grading Instructions INB or myPurdue grading instructions are here: https://www.purdue.edu/registrar/faculty/gradingPWL-grade-entry-update.html<https://www.purdue.edu/registrar/faculty/grading/PWL-grade-entry-update.html>. The full grading policy can be found here: https://catalog.purdue.edu/content.php?catoid=16&navoid=19719#grades-and-gr… Grading questions: Contact the Office of the Registrar by calling (765) 494-6165 or sending an e-mail to registrar(a)purdue.edu<mailto:registrar@purdue.edu> GRADUATE PROGRAM UPDATES Our BME Graduate Committee has been hard at work this year overseeing and evaluating our Graduate Programs and developing policies and statements to help with continuous improvements. Please review the slides (attached) to get a glimpse of the work and learn about several significant policy outcomes including the attached policy statement about AI use in Grad Programs Exams and Evaluations. Upcoming important deadlines and information Mon., April 29: BME PhD Preliminary Exam Announcement for Thejas Vishnu Ramesh (J. Rispoli and V. Rayz, advisors). Everyone is invited to attend the public presentation beginning at 2:00 PM in MJIS 2001 and via Zoom. Research title: Conductive fabric based wearable coil for cervical spine and carotid arteries MRI at 3T. Tues., April 30: Neil Armstrong Distinguished Visiting Professors, 3:00 p.m., WALC 1018. Dr. Ronald Latanision, Sennior Fellow, Exponent, Inc. and Neail Armstrong Distinguished Visiting Professor, School of Industrial Engineering, will present "The Evolution of the Materials Genome Initiative." There will be a reception following the seminar, from 4:00-4:30 p.m. More information at https://engineering.purdue.edu/NADVP?utm_source=delivra&utm_medium=email&ut… Thurs., May 2: Neil Armstrong Distinguished Visiting Professors, 2:40-3:20 p.m., STEW 218. Professor Mordechai Segev, Robert J. Shillman Distinguished Professor of Physics and Electrical Engineering, Technion, Israel, and Neil Armstrong Distinguished Visiting Professor, The Elmore Family School of Electrical and Computer Engineering, Purdue will present "Light-Matter Interactions in Photonic Time-Crystals" as part of the 4th Annual Quantum Summer School, The Quantum Science Center, hosted by Purdue. For more information: https://engineering.purdue.edu/NADVP?utm_source=delivra&utm_medium=email&ut… Tues., May 7: BME PhD Defense Announcement for Vidhya Vijayakrishnan Nair (Yunjie Tong, advisor). Everyone is invited to attend the public presentation beginning at 9:00 AM in MJIS 2001 and via Zoom. Research title: Human Cerebrospinal Fluid Movement across Wake and Sleep States - A Multimodal Imaging Study Thurs., May 9: IBSC-BME Preliminary Exam Announcement for Eric J. Tan (Tamara Kinzer-Ursem, advisor), 2:30 p.m., MJIS 2001. This preliminary exam is open only to those who have signed the Lilly NDA. Title: Developing ultrasensitive point-of-care detection of hyper-phosphorylated tau in patients with preclinical Alzheimer's disease. Committee: Tamara L. Kinzer-Ursem, Chair; Jacqueline Linnes; Jean-Christophe Rochet; Scott C. Bolton Fri., June 7: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor, Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Resources and further information Wed., April 24: PhD Preliminary Exam Announcement for Rachel Stingel (R. Shi, advisor). Everyone is invited to attend the public presentation beginning at 9:00 AM EDT in MJIS 2001 and via Zoom. Title: Acrolein-mediated excitotoxicity following spinal cord injury Committee: Riyi Shi (Chair, advisor), Hyowon (Hugh) Lee, Maria Dadarlat, George M. Smith Abstract: Traumatic spinal cord injury (SCI) causes significant sensory, motor, and autonomic dysfunction for which no established treatment option is available. As such, mechanistic investigation is needed to identify effective therapeutic targets to improve the management of SCI. SCI arises from an initial mechanical impact to the spinal cord (primary injury) and is followed by a series of biochemical cascades (secondary injury) that perpetuate the extent of damage. Oxidative stress and glutamate excitotoxicity are two particularly destructive events that manifest within the first two weeks of SCI. Oxidative stress induces lipid peroxidation (LPO), which results in the production of reactive aldehydes (RA) such as acrolein. Acrolein, a strong electrophile that perpetuates oxidative stress, can bind to and cause irreversible structural changes in target proteins. Glutamate transporter-1 (GLT-1), the chief regulator of extracellular glutamate levels, contains a number of nucleophilic amino acid residues that are likely targets of acrolein. Due to its high reactivity and peak levels coinciding with the progression of excitotoxicity, we hypothesize that acrolein binds to and disrupts the function of GLT-1, which underlies excitotoxicity in the secondary injury. Additionally, we have recently found evidence that acrolein damages aldehyde dehydrogenase 2 (ALDH2), an oxidoreductase that metabolizes RAs, making it largely ineffective in neurotraumatic states. We hypothesize that restoring ALDH2 function will reduce acrolein levels and rescue GLT-1, thereby mitigating excitotoxic damage. Completion of these studies will not only better our overall understanding of the mechanisms underlying secondary SCI, but could also be applied to other neurotraumatic injuries or degenerative diseases with similar underlying pathologies. Zoom link for those who cannot attend: meeting ID: 495 923 5472, https://purdue-edu.zoom.us/j/4959235472<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Wed., April 24: BME Distinguished Research Seminar Series, 9:30 a.m., MRGN 121 and via Zoom. Stacey D. Finley, PhD, Nichole A. and Thuan Q. Pham Professor, University of Southern California will present "Exploring the tumor ecosystem: Modeling across scales." Abstract: My research group works in the area of mathematical oncology, where we use mathematical models to decipher the complex networks of reactions inside of cancer cells and interactions between cells. We have combined detailed, mechanistic and data-driven modeling to study these networks and predict ways to control tumor growth. Our models generate novel mechanistic insight into cell behavior and predict the effects of strategies aimed at inhibiting tumor growth. We have also developed methods of calibrating the models to tumor image data to generate reliable predictive frameworks. In this talk, I will present our work to model the tumor ecosystem across scales: intracellular signaling of immune cells, evolution of cell states, and interactions between tumor and immune cells using agent-based models. Biography: Dr. Stacey Finley is the inaugural Nichole A. and Thuan Q. Pham Professor at the University of Southern California. She is Professor of Biomedical Engineering and Quantitative and Computational Biology. Dr. Finley received her B.S. in Chemical Engineering from Florida A & M University and obtained her Ph.D. in Chemical Engineering from Northwestern University. She completed postdoctoral training at Johns Hopkins University in the Department of Biomedical Engineering. Dr. Finley joined the faculty at USC in 2013, and she leads the Computational Systems Biology Laboratory. Dr. Finley has a joint appointment in the Department of Chemical Engineering and Materials Science, and she is a member of the USC Norris Comprehensive Cancer Center. Dr. Finley is also a standing member of the MABS Study Section at NIH. Her research has been supported by grants from the NSF, NIH, and American Cancer Society. Selected honors. 2016 NSF Faculty Early CAREER Award; 2016 Young Innovator by the Cellular and Molecular Bioengineering journal; Leah Edelstein-Keshet Prize from the Society of Mathematical Biology; Junior Research Award from the USC Viterbi School of Engineering; the Hanna Reisler Mentorship Award; 2018 AACR NextGen Star; 2018 Orange County Engineering Council Outstanding Young Engineer; 2021 Elected Fellow of American Institute for Biological and Medical Engineering; 2022 Fellow of the Biomedical Engineering Society ~ BME Host: Leo Green ~ ZOOM LINK: https://purdue-edu.zoom.us/j/98872914779<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> *Students registered for the seminar are expected to attend in-person. Wed., April 24: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131 and via Zoom. George Smith, PhD, Professor and Vice Chair, Department of Neural Sciences; Interim Director, Shriner's Children Hospitals Pediatric Research Center; Professor of Bioengineering, Lewis Katz School of Medicine at Temple University will present "Rehabilitation Induces Adaptation of Motor Control Pathways after SCI." Abstract: Approximately 18,000 patients each year are affected by spinal cord injury causing motor, sensory and autonomic dysfunction. Children 16 years of age or younger account for 5% of cases with the majority being cervical level that effect forelimb function. To improve their current lifestyle, patients affected by SCI desire return of hand and digit function. However, most spinal cord injury studies examined recovery of locomotion after thoracic lesions in adults and not goal-directed or skilled forelimb movements after cervical injuries, especially in younger animals. In general, the corticospinal tract drives skilled forelimb movements with support from indirect brainstem regions. After lesions to the corticospinal tract there is a significant loss of forelimb function. Our data shows good recovery in juvenile rats when modulated by altering the excitation of the forelimb motor cortex using chemogenetic channels during play which provided a form of physical and social enrichment. Here expression of Designer Receptors Exclusively Activated by Designer Drugs (Dreadds) showed a hierarchy of recovery of forelimb function. Excitatory Dreadds showed the best recover with significant increases in recover above control levels, whereas reduced recovery below control levels was observed when inhibitory Dreadds were expressed within the motor cortex of lesioned CST axons. Likewise, we saw a similar recovery in forelimb kinematics and muscle activity, in which expression of excitatory Dreadds in cortical motor neurons showed the best recovery, followed by mCherry controls with expression of inhibitory Dreadds showing the poorest outcome. We hypothesize that cortical activity modulates axonal sprouting of the lesioned CST, while physical play shapes the connects to promote circuit adaptation rerouting motor commands through brainstem and propriospinal motor systems. We further show that these brainstem and propriospinal networks are involved in relaying the motor command around the spinal cord lesions. Following these circuits, we have developed a novel approach to motor control theory and circuits involved in motor learning supporting rehabilitation. Zoom link: http://bit.ly/42hhhJG<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fbit.ly%2F4…> (Meeting ID: 923 5486 2062, Passcode: CPR. This seminar is sponsored by Purdue's Center for Paralysis Research and Plexon. Thurs., April 25: Seminars in Hearing Research, 12:00 p.m., Nelson Hall Room 1215. Elle O'Brien, PhD, University of Michigan, will present "How will generative AI change scientific software?" Abstract: Across biomedical research areas, scientists make and use code to facilitate data collection, generate data through computational simulations, investigate patterns in data through descriptive statistics and visualizations, and run statistical analyses to connect data to hypotheses. This talk will give an overview of an ongoing research program about the present and future of scientific software with an emphasis on applications to biomedical research. First, we will review findings from a recently-published study of how scientists adopt new software tools for data-intensive research, which sheds light on the pressures currently facing scientists who wish to expand their data analysis toolkit. Second, we will discuss new research that will look at which researchers are using generative AI tools for programming, how researchers reason about the validity of generated code, and how scientific practices and teamwork may be changing as a result. Bio: Elle O'Brien, Ph.D. is a lecturer and research investigator at the University of Michigan. Dr. O'Brien trained at the University of Washington in computational neuroscience methods with a particular focus on the auditory nervous system. Through this work, she became interested in broad questions about how scientists develop software to collect, analyze, and share data and statistical models. Currently, Dr. O'Brien is researching how scientists navigate the use of generative AI tools for programming. This year's SHRP schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fogww.mj.am…> Titles and abstracts of all SHRP talks are here: https://purdue.edu/TPAN/hearing/shrp_abstracts<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fogww.mj.am…> Mon., April 29: BME PhD Preliminary Exam Announcement for Thejas Vishnu Ramesh (J. Rispoli and V. Rayz, advisors). Everyone is invited to attend the public presentation beginning at 2:00 PM in MJIS 2001. Research title: Conductive fabric based wearable coil for cervical spine and carotid arteries MRI at 3T. Thesis committee members: Dr. Joseph Rispoli (co-chair), Dr. Vitaliy Rayz (co-chair), Dr. Craig Goergen (committee member) and Dr. Uzay Emir (committee member). Abstract: MRI is a non-ionizing, non-invasive imaging modality that provides superior soft tissue contrast. Radiofrequency (RF) coils are the antennas through which images are obtained in MRI. Volume coils provide a homogeneous field around the region of interest (ROI) while surface coils help obtain the maximum signal-to-noise ratio (SNR) for high resolution images. Receive arrays are made of multiple surface coils for concomitant acquisition of spatial information from the anatomy, thus enabling parallel imaging. MR angiography (MRA) techniques such as time-of-flight (TOF) MRI and phase contrast (PC) angiography take advantage of parallel imaging to visualize the vasculature and understand the underlying hemodynamics that can lead to cardiovascular diseases, especially in the carotid arteries. A rigid whole neck array that contains coils that extend to the cervical spine are often used to image the carotid arteries. However, the rigid neck array lacks adaptability to varying neck sizes, thus limiting the SNR. Wearable coils that tightly conform around the anatomy of interest developed using techniques such as screen printing, conductive elastomer, and conductive thread reduce coil setup time while ensuring maximum SNR in the final image. However, current wearable coil fabrication methods require specialized manufacturing practices, which render coil development an expensive process. Therefore, a wearable array developed using commercially available conductive fabric is proposed for simultaneous bilateral carotid arteries and cervical spine imaging at 3T. The conductive fabric method eliminates specialized manufacturing needs for developing wearable coils, thus enhancing RF coil accessibility without compromising patient comfort and image quality. Zoom link: https://purdue-edu.zoom.us/j/92041421380?pwd=SGRQaVcvS3MrdEduSHdIazBSNFVkZz…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Tues., May 7: BME PhD Defense Announcement for Vidhya Vijayakrishnan Nair (Yunjie Tong, advisor). Everyone is invited to attend the public presentation beginning at 9:00 AM in MJIS 2001 and via Zoom. Research title: Human Cerebrospinal Fluid Movement across Wake and Sleep States - A Multimodal Imaging Study. Thesis Committee Members: Dr. Yunjie Tong (Chair), Dr. A.J. Schwichtenberg, Dr. Vitaliy L. Rayz, Dr. Yu-Chien Wu. Abstract: The movement of Cerebrospinal Fluid (CSF) within the brain's ventricles and the subarachnoid spaces of both the cranium and spine is crucial for the health and functioning of the central nervous system. Recent research has emphasized CSF movement's importance in metabolic waste clearance and its effect on the pathophysiology of neurodegenerative and neurodevelopmental disorders. Additionally, CSF movement is significantly enhanced during Non-rapid eye movement (NREM) sleep. Despite the critical role of CSF in maintaining brain health, a comprehensive understanding of the mechanisms driving its movement across different states of wakefulness and sleep is lacking. In this work, multimodal imaging was utilized to simultaneously monitor CSF movement and brain hemodynamics via functional Magnetic Resonance Imaging (MRI), neural activity through Electroencephalography (EEG), and non-neuronal systemic physiology via peripheral functional Near-Infrared Spectroscopy (fNIRS). Our findings reveal that CSF movement is influenced by multiple physiological forces concurrently. During wakefulness, both low-frequency vasomotion and respiration interact to regulate CSF movement. Furthermore, systemic physiological changes significantly impact CSF movement during light NREM sleep, even in the presence of autonomic neural activity. Notably, during deep NREM3 sleep, CSF movement magnitude increases independent of the magnitude of brain hemodynamics, suggesting a decrease in impedance to CSF movement and an enhanced exchange between CSF and interstitial fluid (ISF) in the brain. Building on these observations, significant enhancement of CSF movement was also achieved via simple respiratory interventions, thereby demonstrating their potential to be used as clinical protocols across pathologies characterized by reduced CSF movement. Zoom Meeting Link: https://purdue-edu.zoom.us/j/95341354792?pwd=L2ZBTmJYUEVDRXhDTm03cU9JYlBOUT…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Meeting ID: 953 4135 4792 Passcode: 741481 BME Distinguished Seminar Series, 9:30 a.m., MRGN 121 (NOTE LOCATION CHANGE) or via Zoom. Zoom link: https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Note: Students registered for the seminar are expected to attend in-person. Week # Date Speaker Title Host Website 15 4/24/2024 Stacey Finley Nichole A. and Thuan Q. Pham Professor and Associate Professor of Biomedical Engineering, Chemical Engineering and Materials Science, and Quantitative and Computational Biology, USC Kinzer-Ursem Pienaar https://viterbi.usc.edu/directory/faculty/Finley/Stacey<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fviterbi.u…> Postdoctoral Fellow Opportunity - IUSM Emergency Medicine The laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include: (1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally. For additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Findiana.p…> Attachments: Grad Programs update April 2024 for faculty meeting presentation New Policy for AI use in Graduate Programs Exams and Dissertations in BME -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Apply today! Internships and fellowships with DoD through ORISE
by Siemers, Tammy R 22 Apr '24

22 Apr '24

FYI -in case you are interested. Tammy From: orisedodrecruiting(a)orise.orau.gov <orisedodrecruiting(a)orise.orau.gov> Sent: Thursday, April 18, 2024 5:04 PM To: Siemers, Tammy R <tsiemers(a)purdue.edu> Subject: Apply today! Internships and fellowships with DoD through ORISE You don't often get email from orisedodrecruiting(a)orise.orau.gov<mailto:orisedodrecruiting@orise.orau.gov>. Learn why this is important<https://aka.ms/LearnAboutSenderIdentification> ---- External Email: Use caution with attachments, links, or sharing data ---- [https://mcusercontent.com/44959e11342b10cd6967812a8/images/15c0d255-14b2-f1…] The Oak Ridge Institute for Science and Education (ORISE) is accepting applications for paid internship and fellowship opportunities<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> at the U.S. Department of Defense (DoD). Apply now! [https://mcusercontent.com/44959e11342b10cd6967812a8/images/17987cea-8746-f1…] Maximize Your Future with an ORISE Internship or Fellowship<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> When: April 25, 3-4 p.m. ET Looking for a summer opportunity in research, policy or technology? Graduating in spring/summer and ready for the next step in your career path? During the webinar, we'll cover: * Searching and applying for opportunities in Zintellect * Tips for a successful application * A best-in-class ORISE experience Register Today!<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> Information Technology Internship <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> Location: Natick, Massachusetts Degree: High School Diploma/GED, Associate's Degree, or Bachelor's Degree received within the last 60 months or currently pursuing Citizenship: U.S. Citizen USAEC Cultural Resources Internship <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> Location: Fort Huachuca, Arizona Degree: Bachelor's Degree, Master's Degree, or Doctoral Degree received within the last 48 months or currently pursuing Citizenship: U.S. Citizen USAMRIID Human Pathogenic Virus Medical Countermeasure Development Fellowship - Postdoctoral <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> Location: Frederick, Maryland Degree: Doctoral Degree received within the last 60 months Citizenship: U.S. Citizen USAMRIID Therapeutics Fellowship - Master's level <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> Location: Frederick, Maryland Degree: Master's Degree received within the last 48 months Citizenship: U.S. Citizen VIEW MORE OPPORTUNITIES WITH DoD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> [Facebook]<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> [Twitter]<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> [Instagram]<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> [LinkedIn]<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> [Website]<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Forau.us12…> --- If you received this mailing from a colleague and would like to receive future mailings directly in your inbox then please send a blank email to: subscribe-dodinternships(a)listserv.orau.org<mailto:subscribe-dodinternships@listserv.orau.org> ? ? You received this e-mail due to your institutional or organizational affiliation. If we sent this e-mail to you in error, and you wish not to receive any further e-mails from us, please send a blank email to leave-111488-2862850.884bf76079cfa0dcee4c6597339ce304(a)listserv.orau.org<mailto:leave-111488-2862850.884bf76079cfa0dcee4c6597339ce304@listserv.orau.org>

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IBSC-BME Preliminary Exam Announcement for Eric J. Tan (Tamara Kinzer-Ursem, advisor)
by May, Sandra M 22 Apr '24

22 Apr '24

IBSC-BME Preliminary Exam Announcement for Eric J. Tan (Tamara Kinzer-Ursem, advisor) This preliminary exam is open only to those who have signed the Lilly NDA. Title: Developing ultrasensitive point-of-care detection of hyper-phosphorylated tau in patients with preclinical Alzheimer's disease Date: May 9,, 2024 Time: 2:30 pm Location: MJIS 2001 Committee: Tamara L. Kinzer-Ursem, Chair; Jacqueline Linnes; Jean-Christophe Rochet; Scott C. Bolton

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BME PhD Defense Announcement for Vidhya Vijayakrishnan Nair (Yunjie Tong, advisor)
by May, Sandra M 19 Apr '24

19 Apr '24

BME PhD Defense Announcement for Vidhya Vijayakrishnan Nair (Yunjie Tong, advisor) Everyone is invited to attend the public presentation beginning at 9:00 AM. Research title: Human Cerebrospinal Fluid Movement across Wake and Sleep States - A Multimodal Imaging Study Thesis Committee Members: Dr. Yunjie Tong (Chair), Dr. A.J. Schwichtenberg, Dr. Vitaliy L. Rayz, Dr. Yu-Chien Wu. Date, time and place: May 07, 2024 at 9:00 AM at MJIS 2001 and Zoom. Zoom Meeting Link https://purdue-edu.zoom.us/j/95341354792?pwd=L2ZBTmJYUEVDRXhDTm03cU9JYlBOUT…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Meeting ID: 953 4135 4792 Passcode: 741481 Abstract: The movement of Cerebrospinal Fluid (CSF) within the brain's ventricles and the subarachnoid spaces of both the cranium and spine is crucial for the health and functioning of the central nervous system. Recent research has emphasized CSF movement's importance in metabolic waste clearance and its effect on the pathophysiology of neurodegenerative and neurodevelopmental disorders. Additionally, CSF movement is significantly enhanced during Non-rapid eye movement (NREM) sleep. Despite the critical role of CSF in maintaining brain health, a comprehensive understanding of the mechanisms driving its movement across different states of wakefulness and sleep is lacking. In this work, multimodal imaging was utilized to simultaneously monitor CSF movement and brain hemodynamics via functional Magnetic Resonance Imaging (MRI), neural activity through Electroencephalography (EEG), and non-neuronal systemic physiology via peripheral functional Near-Infrared Spectroscopy (fNIRS). Our findings reveal that CSF movement is influenced by multiple physiological forces concurrently. During wakefulness, both low-frequency vasomotion and respiration interact to regulate CSF movement. Furthermore, systemic physiological changes significantly impact CSF movement during light NREM sleep, even in the presence of autonomic neural activity. Notably, during deep NREM3 sleep, CSF movement magnitude increases independent of the magnitude of brain hemodynamics, suggesting a decrease in impedance to CSF movement and an enhanced exchange between CSF and interstitial fluid (ISF) in the brain. Building on these observations, significant enhancement of CSF movement was also achieved via simple respiratory interventions, thereby demonstrating their potential to be used as clinical protocols across pathologies characterized by reduced CSF movement.

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BME Research Symposium Feedback Survey Distribution
by Gelfand, Johanna K 18 Apr '24

18 Apr '24

The BMEGSA team thanks everyone that attended and supported the presenters at the student-led BME Research Symposium that took place on April 16th! Being the first year (in a long time) that the BMEGSA Symposium Committee has organized and hosted a symposium, we would like feedback on parts that went well, and things that we can improve for future symposiums. We have prepared a Feedback Survey<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fforms.gle…> that will take no more than 2-3 minutes, and we welcome any suggestions. We will not collect any names or emails in this survey to encourage honest feedback. Thank you again for supporting the BMEGSA at this event and allowing us to improve for the future. And congratulations to our undergraduate and graduate student presenters for sharing their excellent research work! Best regards, BMEGSA Symposium Committee - Thank you! Brendan K. Ball Ph.D. Candidate in Biomedical Engineering NIH T32 & NSF GRFP Fellow Purdue University | Brubaker Lab

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