November 2023 - Bmegradstudents-list

Weldon Graduate Program Announcements November 29th, 2023
by Siemers, Tammy R 29 Nov '23

29 Nov '23

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements November 29th, 2023 * Career and Internship Opportunities * Fri, 12/1 Inaugural Grant Spotlight Series event, hosted by MD Anderson * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Engineering Intern, R&D/Quality, Stryker<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * R&D Engineering Co-op, Fresenius Medical Care<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjobs.fmcn…> * Graduate Intern, Biomedical Ethics, Mayo Clinic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Graduate Level Internships, Align Technology<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Intern, Thermo Fisher Scientific<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> Postdoctoral Positions * Postdoctoral Associate, Biomedical Engineering, Rutgers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjobs.rutg…> * NPA Website: https://careers.nationalpostdoc.org/jobs/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.n…> Full Time Positions * Process Engineer II, Neurovascular, Medtronic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmedtronic…> * Mechanical Design Engineer II, Medtronic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmedtronic…> * Senior R&D Engineer, Boston Scientific<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjobs.bost…> * Systems Engineer II, Tandem Diabetes Care<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Research Assistant, Orthopaedic Surgery, UCONN Health<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjobs.uchc…> * Quality Engineer II, Biomerics<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Senior Design Engineer, R&D, Ethicon<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjobs.jnj.…> * Biomedical Engineer, Arms & Hands Lab, Shirley Ryan Ability Lab<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fsralab.wd…> * Research Associate, Downstream Process Development, L&J Bio<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Biomedical Engineer, Preclinical, United Therapeutics<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fvhr-unith…> * Reprocessing Content Engineer, Intuitive<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.i…> * Purdue Start-up Job Board<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurduefou…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.a…>-Association for Clinical and Translational Science * Academic Careers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Facademicc…> * Doc Jobs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.docjo…>-Jobs beyond traditional clinical and academic roles Fri, 12/1 Inaugural Grant Spotlight Series event, hosted by MD Anderson Are you planning to submit a K99/R00 grant? Do you need a source of inspiration or an example of a fundable grant to get you started on your writing journey, or to polish off your current K99/R00 application? Do you want to know what K99/R00 grant reviewers look for as indicators of success? If so, then join the Research Education and Training department for its Grant Spotlight Series<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmdanderso…>. The inaugural Grant Spotlight Series event begins on Friday, December 1, 2023 at 1:00 - 2:30 pm CT, via Zoom. This event will feature three panelists who will focus on the NIH K99/R00 funding mechanism. Our first panelist is an MD Anderson professor and reviewer of NIH K awards. The other panelists are two former MD Anderson postdocs (and current Assistant Professors at other institutions) who are K99/R00 recipients and are currently in the R00 phase of their awards. At this event, learn what reviewers look for in a successful application and how our panelists structured their career development plans and responded to critiques. Domestic and Non-Domestic Postdocs are eligible for K99/R00 awards. Panelists: * Clifton (Dave) Fuller, MD, PHD, Professor, Radiation Oncology, UT MD Anderson Cancer Center (NIH K Awards Reviewer) * Guan-Yu Xiao, PhD, Assistant Professor, University of Kentucky, Toxicology & Cancer Biology Department (K99/R00 recipient) * Ivan HC Wu, PhD, Assistant Professor, University of Minnesota Twin Cities, Dept of Epidemiology and Community Health (K99/R00 recipient) To attend the Dec. 1, 2023 Grant Spotlight Series event, please REGISTER HERE<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmdacc.zoo…> to obtain a zoom link. Upon registering, check your email to access an ICS file, to save the zoom link to your Outlook Calendar. Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. Dec 1st Inaugural Grant Spotlight Series (Research Education & Training<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmdacc.zoo…>) Dec 6th Purdue Grad WiE Pop-In (GWEN) Jan. 15th Deadline to apply for NOMIS-Gladstone Fellowship Program (Apply Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgladstone…>) Feb. 2nd Deadline to register for Graduate WiE Symposium (COE<https://www.purdue.edu/wiep/CurrentStudents/Graduate%20Women%20in%20Enginee…>) Feb. 13th 2024 Grad WiE Network Symposium (GWEN<https://www.purdue.edu/wiep/CurrentStudents/Graduate%20Women%20in%20Enginee…>) Feb. 15th Yale University Virtual Postdoc Recruitment Event (Yale<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fyalesurve…>) News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education BME Students (ONLY): Schedule appointments with me via BoilerConnect here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>. Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [cid:image002.png@01DA22D6.0F66EC00]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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TOMORROW: Moderna Industry Networking Event
by Siemers, Tammy R 28 Nov '23

28 Nov '23

Good Morning, This is just a friendly reminder in regards to the Moderna networking night tomorrow night. We hope to see many of you there. Tammy From: bmegsa-bounces(a)lists.purdue.edu<mailto:bmegsa-bounces@lists.purdue.edu> <bmegsa-bounces(a)lists.purdue.edu<mailto:bmegsa-bounces@lists.purdue.edu>> On Behalf Of Biomedical Engineering Graduate Student Association Sent: Tuesday, November 14, 2023 8:00 AM To: bmegsa(a)lists.purdue.edu<mailto:bmegsa@lists.purdue.edu> Subject: [BMEGSA] Moderna Industry Networking Event Hi Everyone! BMEGSA is excited to share that we will be hosting an industry networking event with Moderna on November 29th from 5-6:30pm. The session will take place in MJIS 1097, where we will first get to hear about the mission of Moderna, meet a member from the campus recruitment team, and ask questions to current employees at the company. All are welcome to attend this event! -BMEGSA [cid:image001.png@01DA21DA.D303CE00]

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BME PhD Preliminary Exam Announcement for YunWen (Darren) Chu (S. Pluta and K. Jayant, co-advisors)
by May, Sandra M 28 Nov '23

28 Nov '23

BME PhD Preliminary Exam Announcement for YunWen (Darren) Chu (S. Pluta and K. Jayant, co-advisors) Everyone is invited to attend the public presentation beginning at 10:00am. Title: The neural representation of stimulus priority in the superior colliculus Exam date: 12th Dec 2023 Time: 10:00am Venue: MJIS 2001 Advisory Committee: Scott R. Pluta, Co-Chair; Krishna Jayant, Co-Chair; Maria C. Dadarlat Makin; Michael G. Heinz Abstract: Decision making relies heavily on the ability to distinguish a highly valued stimulus from less valued objects in the environment, such as sensing food amongst rocks. Along the process of perceiving and interpreting the sensory information, a value is assigned to each perceived stimulus such that this newly learned information can assist future goal-directed tasks. How value-modulated sensory processing evolves across cortical and subcortical regions remains poorly understood. Moreover, it is unknown how the neural representations of stimulus value changes with engagement. To answer these questions, we investigate the mouse primary somatosensory cortex (S1) and the superior colliculus (SC) while the animal is performing an active spatial discrimination task. The mice are trained to actively touch and associate a whisker-dependent stimulus with reward (GO whisker) while ignoring tactile input to the adjacent whisker (NoGo whisker). Extracellular neuronal spikes were recorded with high density extracellular silicon probes, and whisker dynamics were recorded with a high-speed camera. Periodically, task engagement was modified by temporarily removing the reward lickport so that the animal lost motivation to respond. We hypothesize that sensory information in the S1 neocortex is encoded in the form of physical features such as location, which is then converted into a map of stimulus value in the SC. We found that both S1 and SC neurons accurately discriminated between adjacent whisker stimuli with the SC displaying a much stronger preference than S1 for the higher-valued stimulus. Unique to SC, many neurons displayed a bidirectional response profile, where spike rate increased during reward-whisker touch, yet it decreased during NoGo whisker touch. Moreover, pre-stimulus baseline activity of SC neurons was strongly modulated by task engagement and in some cases was able to predict upcoming trial performance, suggesting a direct role in initiating goal-directed action. On completion, this study will expand on the model of how value-modulated sensory information is encoded across cortical and subcortical depths, improving our understanding of goal-directed behavior.

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BME PhD Preliminary Exam Announcement for Hayagreev Vadhiraj Sarma Keri (S. Pluta and K. Jayant, co-advisors)
by May, Sandra M 27 Nov '23

27 Nov '23

BME PhD Preliminary Exam Announcement for Hayagreev Vadhiraj Sarma Keri (S. Pluta and K. Jayant, co-advisors) Everyone is invited to attend the public presentation beginning at 2:00 PM. TITLE: Cortical circuit mechanisms underlying the goal-directed flow of bilateral cues EXAM DATE: 12/12/2023 TIME: 2:00 PM LOCATION: MJIS 2001 COMMITTEE MEMBERS: Dr. Scott Pluta (Primary advisor) Dr. Krishna Jayant (Co-advisor) Dr. Maria Dadarlat Dr. Edward Bartlett ABSTRACT: Animal behavior displays inherent bilateral coordination between the left and right sides of the body. However, the neural mechanisms governing the integration of information across hemispheres to generate a unified perceptual experience remains poorly understood. In this proposal, we address this question by recording activity from the cerebral cortices during goal-directed behavior. Due to lack of ipsilateral touch responses in the primary somatosensory cortex(S1), naïve models assume bilateral integration to happen primarily in higher cortical areas. However, since tactile behaviors necessitate high temporal resolution, we propose that S1, fortified by robust callosal projections from the contralateral hemisphere, likely plays a crucial role in bilateral integration and in tuning stimulus information in downstream regions. To tackle this question, we developed a novel Go/No-go bilateral discrimination task where mice discriminate between bilateral stimuli categories, compelling them to share tactile information across hemispheres. We observed that mice enhance the bilateral whisker movement symmetry during 'Go' stimulus presentation. Examination of neural activity revealed strong temporal coupling between the S1s along with enhanced ipsilateral facilitation modulated by behavioral context. Our findings challenge existing models and propose a novel framework suggesting that behavioral context governs bilateral integration in the sensory cortex. Additionally, neurons in the whisker motor cortex (wMC) were also found to accurately decode sensory and motor variables during the bilateral task. By innovative optogenetic axon silencing of specific feedforward projection neurons, we aim to dissect the circuits underlying this brain-wide computation. Completing this proposal will provide insights on the circuits and cell-types underlying bilateral sensation and movement.

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REMINDER: Call for Nominations: Bilsland Dissertation Fellowship--DUE December 3rd
by Siemers, Tammy R 27 Nov '23

27 Nov '23

Good Morning and Happy Monday! Please consider this your friendly reminder that the Bilsland nominations are due at the end of this weekend. I hope you all had a nice and relaxing Thanksgiving break! Tammy From: Siemers, Tammy R Sent: Monday, November 6, 2023 8:18 AM To: Siemers, Tammy R <tsiemers(a)purdue.edu> Subject: Call for Nominations: Bilsland Dissertation Fellowship--DUE December 3rd Good Morning, The following message was sent to our faculty this morning. If you are interested in being nominated for this fellowship, make sure to mention something to your faculty advisor. Have a great start to your week. Tammy From: Siemers, Tammy R Sent: Monday, November 6, 2023 8:11 AM To: bmewlfaculty-list(a)ecn.purdue.edu<mailto:bmewlfaculty-list@ecn.purdue.edu> Subject: Call for Nominations: Bilsland Dissertation Fellowship--DUE December 3rd Good Morning- The Bilsland Dissertation Fellowship provides support for outstanding PhD candidates in their final year or semester of doctoral degree completion. The goal of the fellowship is to allow exceptional candidates to focus exclusively on finishing their dissertation. The Graduate School Fellowship Manual has additional details https://www.purdue.edu/gradschool/fellowship/fellowship-resources-for-staff… Note: Students in other schools outside of BME should follow those schools procedures. Due Date: Sunday, December 3rd (tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>) Student Eligibility * At the time of nomination, students must have 1) completed their preliminary exam or, 2) submitted the paperwork scheduling their preliminary exam for a date before May 31. * Students who will complete their defense prior to September 1, 2024, are not eligible. * Students who need less than 1 semester of support are not eligible. * Nominees must be outstanding engineering PhD students. * The following criteria will be used to rank the nominees: * Merit. Includes publications, conference presentations, GPA etc. * Funding need. * Good citizen of the School and College. Includes service. * Career promise. Includes leadership, innovation, readiness and potential to make an impact. Application Package Should Include the following in one PDF: * A letter (limit 2 pages) from the major professor nominating the student and confirming that the student's expected graduation date. This can be sent separately if the student is providing the rest of the information. * The student's thesis abstract, * A copy of the preliminary examination paperwork (to confirm the student is on track to graduate next year), * The student's CV, * A copy of the student's most recent transcript - graduate work only. Salary & Usage: * This fellowship includes $30,000 annual salary, tuition remission, medical insurance premium contribution, and coverage of most fees. Engineering differential fee is not covered. * Bilsland Fellowships are administered as assistantships. It is expected that job duties will contribute to the completion of the student's dissertation. * Bilsland's must be awarded in the student's last term, and the student is expected to graduate at the end of the fellowship term. * This year's Bilsland allocation may be used Summer 2024, Fall 2024, Spring 2025, or Summer 2025. * No additional work appointments may be added, but faculty may (and perhaps must; depending on our minimum salary requirement which may be set in BME) increase the salary or provide additional funds as scholarships. * The fellowship is to be awarded for the full 12 months or until the student graduates, whichever comes first. * Fellowship recipients who graduate before the completion of the fellowship or otherwise stop the fellowship before the full 12 month duration forfeit any remaining funds. * If Bilsland Fellows do not graduate as expected this could hurt our funding allocation from the Graduate School, so please only nominate students you truly expect to graduate and are truly in their final year. The announcement will go out to the students as well. Please let me know if you have any questions. Enjoy your day! Tammy Tammy Siemers Senior Graduate Training Program Administration and Professional Development Specialist Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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[Bmeroundtable-list] BME Weekly Roundtable, November 27, 2023
by Gelfand, Johanna K 27 Nov '23

27 Nov '23

[cid:image001.jpg@01DA211C.23823E30] BME WEEKLY ROUNDTABLE WEEK OF November 27, 2023 INTERIM HEAD'S NOTE Welcome back. I hope you had a great Thanksgiving holiday. We have three more weeks in this semester, including the finals week. Coming down the stretch, everyone is busy. So please take care of yourself and your students both mentally and physically, especially as we finally start to get cold weather. In this Friday's faculty meeting, we will talk about academic programs and teaching in general. The purpose is to share information and start these discussions critical to our department. * Vitaliy will present an overview of our academic programs, UG curriculum, teaching load, and the use of lecturers and professors of engineering practice. * To supplement, Tami Kinzer-Ursem and Milind Kulkarni will present an overview of graduate and professional programs and online programs at the college level, respectively. I feel these are the areas where we see room to improve for the department. * With the IUPUI integration, four Purdue Indy BME faculty will join us. On Nov. 29th, the event Celebrating Our Associate Professors will be held in Purdue Graduate Student Center (PGSC) 105 A&B. For more details, please see the following "Upcoming Important Dates." Luis Solorio will talk about his journey. This semester, he is the only BME representative. If you have time, please attend to celebrate with him. UPCOMING IMPORTANT DATES Week of November 27 Tues., Nov. 28: BME PhD Preliminary Exam Announcement for Taewoong Park (C.H. Lee, advisor). Everyone is invited to attend the public presentation beginning at 12:00PM in MJIS 2001. Title: Design, fabrication, and implementation of wearable biomedical devices for chronic disease management. Wed., Nov. 29: BME Distinguished Seminar Series, 9:30 a.m., MJIS 1001 or via Zoom. Sarah Wiehe, MD, MPH, the Jean and Jerry Bepko Professor of Pediatrics and Associate Dean of Community and Translational Research at the Indiana University School of Medicine will present "Community-engaged research: A path to meaningful work as a translational scientist." Wed., Nov. 29: Celebrating Our Associate Professors, 11:30 a.m. in Purdue Graduate Student Center (PGSC) 105 A&B. The College of Engineering is pleased to present its Fall 2023 Celebrating Our Associate Professors lunch session on Wednesday, November 29. The four faculty who will be featured include Luis Solorio (BME), Mohit Verma (ABE and BME), Maria Okuniewski (MSE) and David Johnson (IE). Each event in the series features recently tenured associate professors making brief presentations on aspects of their teaching/learning, research and/or engagement activities and reflecting on the paths and decisions they took toward their success. There will also be opportunities to have conversations about the presented work with colleagues in attendance. Please register at https://bit.ly/1123-COAP The celebration is hosted by Purdue's College of Engineering. Wed., Nov. 29: BME PhD Preliminary Exam Announcement for Seokkyoon Hong (C.H. Lee, advisor). Everyone is invited to attend the public presentation beginning at 3:00 PM in MJIS 2001. Title: Soft Materials for Wearables. Wed., Nov. 29: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131. Koji Uchida, Professor of Food Chemistry, University of Tokyo will present "Conversion of Proteins into DNA Mimetics by Reactive Aldehydes." This seminar series is organized by the Center for Paralysis Research and supported by Plexon, the Purdue Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. The Zoom link is: https://bit.ly/441Dllq<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbit.ly%2F…>. For additional information, see https://vet.purdue.edu/cpr/ Wed., Nov. 29: Telephone System Update Implemented, 7:00 p.m. Purdue IT is completing the long-running project to retire the phone switch installed more than 25 years ago. Beginning after 7:00 p.m. EST, November 29, changes to the way you use the Purdue West Lafayette telephone systems will be required. See link below for details. Thurs., Nov. 30: BME Master's Defense Announcement for Benjamin Dahl (T. Kinzer-Ursem, advisor). Everyone is invited to attend the public presentation beginning at 8:00am in BRK 1001. Title: Fundamental and applied modeling in neurology: post-synaptic kinase anchoring and DNA amplification assays. Thurs., Nov. 30: BME-IBSC PhD Defense Announcement for Seul Ah Lee (C.H. Lee, advisor). Everyone is invited to attend the public presentation beginning at 9:00 AM in MJIS 2001 and via Zoom. Title of Thesis Research: "Development of Vision and Eye Care Smart Contact Lens." Thurs., Nov. 30: Seminars in Hearing Research, 12:00 p.m., Nelson Hall, Room 1215. Cole Trent, PhD Student, SLHS will present "Discrimination of intact vs. elliptical sentences in CI-simulated speech." Thurs., Nov. 30: BME Master's Defense Announcement for Nafisa Rafiq (M. Verma, advisor). Everyone is invited to attend the public presentation beginning at 3:00PM in ABE 5078. Title of Thesis Research: Design and development of a field deployable heating system for loop-mediated isothermal amplification. Thurs., Nov. 30: BME Master's Defense Announcement for LeRayah Neely-Brown (M. Ward and D. Umulis, co-advisors). Everyone is invited to attend the public presentation beginning at 3:00 PM in BRK 2001 and via Zoom. Title: Predicting General Vagal Nerve Activity via The Development of Biophysical A.I. Thurs., Nov. 30: Purdue Engineering Distinguished Lecture Series. Julian Allwood, Professor of Engineering and the Environment, University of Cambridge, England will present "Making (Good) Things Happen." This virtual seminar is hosted by the College of Engineering, and Environmental and Ecological Engineering. Register at bit.ly/pedls-allwood Fri., Dec. 1: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Learn about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Jackie Linnes, Associate Professor of Biomedical Engineering at Purdue. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Fri., Dec. 1: The deadline for students to schedule their final exams with Purdue Testing Services (PTS). Students who miss the deadline will be redirected to their instructors to discuss alternate arrangements to still receive their accommodations. Fri., Dec. 1: Indiana Life Sciences Conference - "Closing the Gap of Health Inequalities," 8:00 a.m. - 3:15 p.m., Roche Diagnostics, Indianapolis. See below for details. Fri., Dec. 1 through Tues., Dec. 19: Grade entry begins at 8 a.m. December 1 and ends at 5 p.m. December 19. Fri., Dec. 1: Applications due for the Midwestern Association of Graduate Schools (MAGS) 2024 Excellence in Teaching Awards Competition. See below for details. Sun., Dec. 3: The Bilsland Dissertation Fellowship nominations due to Tammy Siemers (tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>). See below for details. MJIS ALERT As of Mon., Nov. 27: The Club Room on the 1st floor of MJIS will be CLOSED indefinitely. A recent inspection by REM revealed numerous sanitation issues (food debris, uncleaned appliances, evidence of mice, etc.). As this is a recurring problem, they have shut the room down until it can be deep cleaned with an assurance that it will be maintained to university standards in the future. Stay tuned. Any questions can be submitted to Susan Hardy (hardy13(a)purdue.edu) As of Wed., Nov. 29: Telephone System Update Implemented, 7:00 p.m. Purdue IT is completing the long-running project to retire the phone switch installed more than 25 years ago. Beginning after 7:00 p.m. EST, November 29, changes to the way you use the Purdue West Lafayette telephone systems will be required, including required use of area codes for ALL calls. See link below for details. ACADEMIC PROGRAMS ALERT Re: final exam accommodations. We have a number of students who may need accommodations for final exams and faculty need to be proactive in scheduling with the Testing Center if they plan to use that. Below is some important information instructors should know if they choose to have Purdue Testing Services (PTS) administer their accommodated exams. * The steps to submit a Testing Instruction Form (TIF) for finals week are the same as any other exam with one notable difference. In the "select the exam group/s for this test" field, be sure to select your course that starts with Accommodated FINAL Exam. This is required before students will be able to schedule during finals week. *If you had already submitted a TIF for your final prior to receiving this email, PTS staff updated your TIF to the correct exam group * Hours of operation: * Monday - Friday | 8 a.m. - 10 p.m. * Exam start times: 8 a.m., 10:30 a.m., 1 p.m., 3:30 p.m., 6 p.m. and 7 p.m. * Saturday | 8 a.m. - 4:30 p.m. * Exam start times: 8 a.m., 10:30 a.m., Noon and 1 p.m. * Due to the volume of exams we administer, we will not start any exam outside of the start times mentioned above. Please take this into consideration if you are adding time restrictions to your TIF. * The deadline for students to schedule their final exams with PTS is Dec. 1, 2023. Students who miss the deadline will be redirected to their instructors to discuss alternate arrangements to still receive their accommodations. * There may be times when PTS reaches full capacity prior to the scheduling deadline. If this occurs, instructors will either be asked to select a different day/start time in which PTS has seats available or they will need to make alternate arrangements to provide the accommodations. Another email will be sent closer to finals week with more important information regarding delivery and return methods. Instructors may find up-to-date information as well as step-by-step guides on our website<https://maillinks.purdue.edu/t/45449744/1695007246/97441342/0/1003726/?x=2c…>. Thanks, Kelsey Jordan, M.S. she/her/hers Director, Purdue Testing Services ALSO: We are now more than halfway through the Fall term so here are some reminders as we round the corner to final grading: * This is the perfect time to ensure that your web certifications are current so you don't get stuck during a deadline. FERPA, GLBA, Protecting SSNs, and Data Handling all must be current at the time of grade entry to prevent any roadblocks. * Final grading window https://www.purdue.edu/registrar/faculty/grading/index.html Full Term (16 Weeks) and Second Eight-Week Session (meeting between October 18 and December 16) Grade entry begins at 8 a.m. December 1 and ends at 5 p.m. December 19. Virtual Workshop Series on Mastering Grant Writing Tommy Sors, Director of Scientific Strategy and Relations, invites you to elevate your research potential by registering to be part of our exclusive workshop series, meticulously designed to guide you through the competitive landscape of NIH funding and the art of grant writing. Each session builds on the next, so you want to make sure to catch all sessions because they offer the knowledge and tools to craft winning proposals. Sessions will run on Thursdays from 2:00-3:00 p.m. November 30 - December 14 and Tuesdays 10:00-11:00 a.m. January 9-Feb. 13. Register at https://purdue.ca1.qualtrics.com/ife/form/SV_01WMuhATStggQOW<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> GRADUATE PROGRAM UPDATE Fellowship Opportunity The Bilsland Dissertation Fellowship provides support for outstanding PhD candidates in their final year or semester of doctoral degree completion. The goal of the fellowship is to allow exceptional candidates to focus exclusively on finishing their dissertation. The Graduate School Fellowship Manual has additional details https://www.purdue.edu/gradschool/fellowship/fellowship-resources-for-staff… Note: Students in other schools outside of BME should follow those schools' procedures. Due Date: Sunday, December 3rd (tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>) Student Eligibility * At the time of nomination, students must have 1) completed their preliminary exam or, 2) submitted the paperwork scheduling their preliminary exam for a date before May 31. * Students who will complete their defense prior to September 1, 2024, are not eligible. * Students who need less than 1 semester of support are not eligible. * Nominees must be outstanding engineering PhD students. * The following criteria will be used to rank the nominees: * Merit. Includes publications, conference presentations, GPA etc. * Funding need. * Good citizen of the School and College. Includes service. * Career promise. Includes leadership, innovation, readiness and potential to make an impact. Application Package Should Include the following in one PDF: * A letter (limit 2 pages) from the major professor nominating the student and confirming that the student's expected graduation date. This can be sent separately if the student is providing the rest of the information. * The student's thesis abstract, * A copy of the preliminary examination paperwork (to confirm the student is on track to graduate next year), * The student's CV, * A copy of the student's most recent transcript - graduate work only. Salary & Usage: * This fellowship includes $30,000 annual salary, tuition remission, medical insurance premium contribution, and coverage of most fees. Engineering differential fee is not covered. * Bilsland Fellowships are administered as assistantships. It is expected that job duties will contribute to the completion of the student's dissertation. * Bilsland's must be awarded in the student's last term, and the student is expected to graduate at the end of the fellowship term. * This year's Bilsland allocation may be used Summer 2024, Fall 2024, Spring 2025, or Summer 2025. * No additional work appointments may be added, but faculty may (and perhaps must; depending on our minimum salary requirement which may be set in BME) increase the salary or provide additional funds as scholarships. * The fellowship is to be awarded for the full 12 months or until the student graduates, whichever comes first. * Fellowship recipients who graduate before the completion of the fellowship or otherwise stop the fellowship before the full 12 month duration forfeit any remaining funds. * If Bilsland Fellows do not graduate as expected this could hurt our funding allocation from the Graduate School, so please only nominate students you truly expect to graduate and are truly in their final year. The announcement will go out to the students as well. Please let me know if you have any questions. Excellence in Teaching Awards Competition Applications are now being accepted for the Midwestern Association of Graduate Schools (MAGS) 2024 Excellence in Teaching Awards Competition. The University is eligible to nominate one masters-level and one Ph.D.-level student for each award that includes a citation and a $750 honorarium that will be presented at the MAGS annual meeting on April 3-5, 2024. Interested students must submit their application materials to the Graduate School by Friday, December 1, 2023, at 5:00 p.m. for consideration. Award Details * The 2024 Excellence in Teaching Awards will be bestowed on "...graduate students who exemplify excellence in the teaching and learning mission of our universities.... [to] recognize the importance of excellence in teaching and mentoring as a component of graduate education and the preparation of graduate students for future service as college and university faculty." * Details of the Award, as well as a list of previous recipients, are available here: https://mags-net.org/excellence-in-teaching-award/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmags-net.…> * The Dean of the Graduate School/College (or designee) at each MAGS-affiliated university may select and submit the materials of one doctoral and one masters-level graduate student for these awards. * MAGS's evaluation criteria are shared here: https://mags-net.org/wp-content/uploads/2023/10/2024_MAGS_Exc_Teach_Award_E…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmags-net.…> Submission Details Graduate students wishing to be considered for this award must submit a single PDF document that includes: * a letter of nomination from the student's department head * the nominee's teaching portfolio * up to six (6) pages, double-spaced, 1-inch margins, with a 12-point font * an embedded link to a video (maximum of 10 minutes) showing the nominee teaching in an educational setting of a collegiate-level course * for instructions on saving and submitting a suitable video, please see: https://mags-net.org/wp-content/uploads/2023/10/2024_MAGS_Exc_Teach_Award_Y…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmags-net.…> * all individuals who are identifiable in the video and over the age of 18 should complete a consent and release form, and the portfolio description of the video should indicate that these have been collected. The Use of Photographic and Vido/Film Consent and Release Form can be completed (and will be stored) online via Qualtrics here: * https://purdue.ca1.qualtrics.com/jfe/form/SV_8AZILsZOZwtg96u<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> * the student's current curriculum vitae * Since Purdue must review and select nominees' materials to be sent along to MAGS, materials should be submitted by Friday, December 1, 2023, at 5:00 p.m. to * MAGS_Ex.oewymn7ybxjoxsm0(a)u.box.com<mailto:MAGS_Ex.oewymn7ybxjoxsm0@u.box.com> Timeline toward nomination * Purdue deadline for submissions: Friday, December 1, 2023 * Review of campus nominees: December 4-11, 2023 * Notification of campus nominees: December 15, 2023 * Completion of nomination packets (including an endorsement from the Associate Provost for Graduate Programs) and submission to MAGS: January 5, 2024 Questions? Please contact Associate Dean David Rollock at the Graduate School (rollock(a)purdue.edu<mailto:rollock@purdue.edu>; 496-2775). Three Minute Thesis Competition Nominate a graduate student to represent your academic unit! The Graduate School's annual Three Minute Thesis competition is scheduled for April 9th! To increase academic representation in our 3MT® competition, we are asking that West Lafayette graduate faculty members nominate talented graduate student(s) to represent their academic units. Nominees must be current Purdue graduate students in the final stages of their research. Each nominee will be contacted by Graduate School staff and encouraged to register for the competition. Nominations are not required for students to submit a draft video; they are simply intended to help the Graduate School identify and encouraged talented students to participate. I have shared the link to the nomination form below, as well as some additional information about the Graduate School's 3MT® competition. Please email me, Allison Loy (Loy2(a)purdue.edu<mailto:Loy2@purdue.edu>), with any questions! 3MT® 2024 Nomination Form<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>: * Nomination Deadline: January 15, 2024 What is 3MT®? Three Minute Thesis (3MT®) is a research communication competition that helps graduate students develop academic, presentation, and research communication skills so that they can effectively explain their research to a non-specialist audience. During each competition, graduate students will have three minutes to present a compelling discussion on their research topic, including its significance and relevance, to the public. This is a fast-paced competition where the top 10 finalists compete by summarizing their two to three-plus years of research in only three minutes with only one slide. The cash awards for this year's competition are $5,000 for first place, $3,000 for second place, and $2,000 for the People's Choice Award winner. The first-place winner will also be invited to compete in the Midwestern Association of Graduate School's (MAGS) annual 3MT® competition. 3MT® Timeline * Friday, February 9: Draft Video Submission Deadline - Learn more about making a draft video!<https://www.purdue.edu/gradschool/professional-development/documents/Virtua…> * Friday, February 16: Semifinalists Announced * Friday, February 23: Semifinals - in person * Monday, February 26: Finalists Announced * Tuesday, April 9: Competition - in person Learn more about the Purdue University Graduate School's 3MT® competition at the following URL: https://www.purdue.edu/gradschool/professional-development/competitions/3mt… Thank you, Allison Loy (s/h) Loy2(a)purdue.edu Professional Development Events Coordinator Office of Graduate Professional Development The Graduate School Upcoming important deadlines and information Mon., Dec. 4: BME PhD Defense Announcement for Conner C. Earl (C. Goergen, advisor). Everyone is invited to the public presentation beginning at 10:00am in MJIS 2001 or via Zoom. (10:00-11:00 am open portion, 11 am-12 pm closed portion)Title: Advanced Characterization of Cardiac Pathology Using 4D Medical Imaging. Wed., Dec. 6: BME-IBSC PhD Preliminary Exam Announcement for Brock Beauclair (R. Shi, advisor). Everyone is invited to attend the public presentation beginning at 2:00PM in Morgan (MRGN) 129. Research Title: Establishing an in vitro Model of Blast Induced Traumatic Brain Injury Thurs., Dec. 7: BME PhD Preliminary Exam Announcement for Sang Hoon Um (L. Green, advisor). Everyone is invited to attend the public presentation beginning at 2:30PM in MJIS 2001. Title: Retooling the membrane channel with DNA nanostructure for simultaneous and precise voltage recording. Mon., Dec. 11: BME PhD Preliminary Exam Announcement for Grigorii Rudakov (T. Kinzer-Ursem and L. Green, co-advisors), 10:00 a.m., MJIS 1001. Title: "DNA Tetrahedron Design Optimization for Efficient Drug Delivery Through the Blood-Brain Barrier." Thurs., Dec. 14: SAVE THE DATE: 2023 Senior Design Projects Expo and Awards Ceremony, 3:30-5:30 p.m., MJIS. Please mark your calendars and plan to join us to celebrate the achievements of our 2023 senior design teams. The expo will highlight 30 innovative engineering solutions, followed by a live awards ceremony. Mon., Jan. 15: Nomination Deadline for Three Minute Thesis Competition. See full article for details. The actual competition will occur on Tuesday, April 9th. Tues., Jan. 23: Purdue Engineering Distinguished Lecture Series. Yannis C. Yortsos, Dean of Biterbi School of Engineering, Zohrab Kaprielian Dean's Chair in Engineering, University of Southern California will present "The Intertwining of Engineering with Social Phenomena." This seminar is hosted by the College of Engineering, and Davidson School of Chemical Engineering. Register at bit.ly/pedls-yortsos Wed., Feb. 21: Purdue Engineering Distinguished Lecture Series. Russell Allgor, Vice President and Chief Scientist, Worlwide Operations at Amazon.com will present "Logistics and Fulfillment Systems for E-Commerce." This seminar is hosted by the College of Engineering, and School of Industrial Engineering. Register at bit.ly/pedls-allgor Fri., March 1: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Andrew Miller, Associate Professor and Chair, Department of Hunan-Centered Computing, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Wed., March 6: Purdue Engineering Distinguished Lecture Series. Karen Willcox, Director, Oden Institute for Computational Engineering and Sciences, Associate Vice President for Research, and Professor of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin will present "From Reduced-Order Modeling to Scientific Machine Learning: How Computational Science is Enabling the Design of Next-Generation Engineering Systems." This seminar is hosted by the College of Engineering, and School of Mechanical Engineering. Register at bit.ly/pedls-willcox Wed., April 10: Purdue Engineering Distinguished Lecture Series. Jeffrey Dean, Google Senior Fellow and SVP of Google Research and Google Health, Google Research will present "Machine Learning, AI and Applications of AI." This seminar is hosted by the College of Engineering, and Elmore Family School of Electrical and Computer Engineering. Register at bit.ly/pedls-dean Fri., June 7: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor, Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Resources and further information Tues., Nov. 28: BME PhD Preliminary Exam Announcement for Taewoong Park (C.H. Lee, advisor). Everyone is invited to attend the public presentation beginning at 12:00PM in MJIS 2001. Title: Design, fabrication, and implementation of wearable biomedical devices for chronic disease management. Committee members: Prof. Chi Hwan Lee (Chair), Prof. Hugh Hyowon Lee, Prof. Young L. Kim, Prof. Fengqing Zhu (Electrical & Computer Engineering) Abstract: The development of wearable devices that monitor biometric signals in real-time to aid in maintaining health has played a crucial role in the field of biomedical engineering. In our rapidly evolving world, chronic diseases such as hypertension, diabetes, obesity, and heart diseases have imposed severe health and cost implications on public health. This has led to an increased demand for smart healthcare that can remotely and accurately measure and monitor long-term period. While wearable sensing technologies have made significant advancements, tracking specific diseases in real-time remains a challenging task. To address these challenges, we present a series of innovative wearable devices, each uniquely designed to tackle specific aspects of these health concerns. The first is a machine learning-enabled smart neckband designed to precisely monitor dietary intake for patients with diabetes and obesity. This device can effectively distinguish between various activities like body movements, speech, fluid intake, and food intake, showcasing a comfortable and ergonomically designed solution. Another contribution is a custom-designed wearable device focused on the real-time monitoring and classification of vocal cord dysfunction, efficiently differentiating between body movements and vocal cord closures. Extending beyond human health, we also investigate the healthcare of animals. Communication barriers often hinder the timely diagnosis of symptoms in animals. Addressing this, we introduce a wearable device for large animals, such as horses. This device is centered on monitoring respiration in real time, a critical tool for managing conditions like asthma. Wed., Nov. 29: BME Distinguished Seminar Series, 9:30 a.m., MJIS 1001 or via Zoom. Sarah Wiehe, MD, MPH, the Jean and Jerry Bepko Professor of Pediatrics and Associate Dean of Community and Translational Research at the Indiana University School of Medicine will present "Community-engaged research: A path to meaningful work as a translational scientist." Abstract: In this talk, I will share my career path as a physician-scientist trained in epidemiology which took a turn for the better after facing recruitment challenges with my first funded project. I will present my research tracking adolescent girls using GPS-enabled cell phones (back when we had blackberry pearls) and discuss what I learned in terms of the benefits of stakeholder engagement and human-centered design research. I will also share how this led to additional interdisciplinary research and leadership opportunities as part of the Indiana CTSI. Biography: Sarah Wiehe, MD, MPH is the Jean and Jerry Bepko Professor of Pediatrics and Associate Dean of Community and Translational Research at Indiana University School of Medicine. She is a Research Scientist at the Regenstrief Institute and Adjunct Professor of Epidemiology at Fairbanks School of Public Health at Indiana University. Dr. Wiehe co-directs the Indiana Clinical and Translational Sciences Institute (CTSI) and leads its community engagement program. The Indiana CTSI serves researchers and partners with patients and community members, community-based organizations, healthcare systems, and governmental agencies to translate scientific evidence into practice and policy. Dr. Wiehe's research focuses on addressing health equity outcomes among vulnerable populations, including individuals involved with the justice system, living in poverty, diagnosed with mental health and substance use disorder diagnoses, experiencing trauma, and living with HIV. She has expertise in the community engagement, patient-centered research methods, creative use of existing data, data-sharing partnerships, and health services research. Her work has been funded by the National Institute of Health, the Patient-Centered Outcomes Research Institute, and the Robert Wood Johnson Foundation. As a general pediatrician, Dr. Wiehe enjoys seeing patients at Eskenazi Health Center, the largest Federally Qualified Health Center network in Indianapolis, Indiana, and supervising and training pediatric residents. Dr. Wiehe earned her bachelor's degree in economics and biology and her medical degree from the University of Chicago. She completed her internship and residency in pediatrics and her master's in public health in epidemiology at the University of Washington, where she completed a postdoctoral fellowship with the Robert Wood Johnson Clinical Scholars Program. ~ BME Host: George Wodicka ~ Zoom link: https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> NOTE: *Students registered for the seminar are expected to attend in-person. Wed., Nov. 29: BME PhD Preliminary Exam Announcement for Seokkyoon Hong (C.H. Lee, advisor). Everyone is invited to attend the public presentation beginning at 3:00 PM in MJIS 2001. Title: Soft Materials for Wearables. Committee members: Prof. Chi Hwan Lee (Chair), Prof. Hyowon Hugh Lee, Prof. Young L. Kim, and Prof. Luis Felipe Neves Dos Santos (College of Veterinary Medicine) Abstract: The wearable industry is experiencing a significant upward trajectory, marked by a diverse array of technological applications. These applications span a wide spectrum, encompassing real-time health monitoring, human-machine interfaces, and more. However, a prevailing sentiment persists - that being "wearable isn't always truly wearable." This sentiment emerges due to the prevailing issues within the current market offerings of wearable sensors, which tend to be bulky and rigid leading to uncomfortable user experiences, artifacts in motion tracking, and compromised data accuracy. As a response to this challenge, a global and vigorous pursuit of innovative materials and structures has been ignited. This preliminary report aims to offer strategies towards "truly wearables" in focusing on the pivotal role of material and structural innovation. This preliminary report presents a comprehensive set of material innovations and structural designs to develop mechanically "soft materials" tailored for wearable applications. In the first part of this preliminary report, emphasis is placed on the material design aspect, on the development of a "Rapid self-healing hydrogel with ultralow electrical hysteresis for wearable sensing." The second part introduces another material design, highlighting the creation of a "Tough conductive organohydrogel for wearable sensing in extreme environmental conditions." The third section delves into structural design considerations, focusing on the development of a "Spongy Ag foam for soft and stretchable strain gauges." Wed., Nov. 29: Telephone System Update Implemented, 7:00 p.m. Purdue IT is completing the long-running project to retire the phone switch installed more than 25 years ago. Beginning after 7:00 p.m. EST, November 29, the following changes to the way you use the Purdue West Lafayette telephone systems will be required. 1. Moving to utilize 10-digit dialing for all outgoing calls. This dialing method requires users to dial 1 + the area code of the person being called as part of the dialing process. However, 5-digit internal to campus dialing will remain the same. This is a requirement dictated to use by our Carrier and is now standard nationwide. If you would like to know more about 10-digit dialing, the following website contains more information: https://www.fcc.gov/consumers/guides/ten-digit-dialing<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.fcc.g…> * Local AND Long Distance call: 7 + 1 + 10 digit = 7-1-(317)-555-5555 * International call: 7 + 011 + country code + local number 2. International Calling: The current process using international access codes will no longer be supported. If you currently have an international calling code and need the ability to dial internationally then please complete the form at: https://purdue.ca1.qualtrics.com/jfe/form/SV_1FVkar7IS9zKvjg<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Purdue IT strives to provide a top-quality telecommunications system and appreciates your support as we continue to upgrade our services and provide a highly reliable service. If you should have questions or concerns, please contact it(a)purdue.edu<mailto:it@purdue.edu>. Thurs., Nov. 30: BME Master's Defense Announcement for Benjamin Dahl (T. Kinzer-Ursem, advisor). Everyone is invited to attend the public presentation beginning at 8:00am in BRK 1001. Title: Fundamental and applied modeling in neurology: post-synaptic kinase anchoring and DNA amplification assays. Committee members: Dr. Tamara Kinzer-Ursem (chair), Dr. Elsje Pienaar, and Dr. Scott Bolton Abstract: Computational modeling has a broad range of applications in neuroscience, from discovering fundamental attributes of neuronal synaptic function to helping develop tools to fight neurodegenerative disorders. Here, we utilize computational modeling to investigate the dynamics of receptor phosphorylation that are important in regulating dynamic changes in synaptic strength. Within synapses, a thick network of proteins makes up a membrane-less structure called the post-synaptic density (PSD) in post-synaptic dendritic spines. The increased number and phosphorylation of glutamate receptors within the PSD is a hallmark of increased synaptic strength. A-kinase anchoring proteins (AKAPs) are important scaffolding proteins in the PSD that have been established to localize a number of regulatory enzymes such as protein kinase A, calcineurin, and phosphodiesterases near the cell membrane and glutamate receptor tails. However, it is still unclear what is their overall effect on glutamate receptor phosphorylation and trafficking. Here, a spatial stochastic computational model of AKAP and enzymatic binding partners in the PSD is developed and the dynamics of the system analyzed. Model results demonstrate the correlation between glutamate receptor tail phosphorylation and AKAP localization. By computational "knockdown" of AKAPs we are able to quantify their effect on glutamate receptor phosphorylation, investigate the role of spatial localization, and posit their potential impacts on LTP and synaptic plasticity. Thurs., Nov. 30: BME-IBSC PhD Defense Announcement for Seul Ah Lee (C.H. Lee, advisor). Everyone is invited to attend the public presentation beginning at 9:00 AM in MJIS 2001 and via Zoom. Title of Thesis Research: "Development of Vision and Eye Care Smart Contact Lens." Thesis Committee: Dr. Chi Hwan Lee (Chair), Dr. Young L. Kim, Dr. Hugh Hyowon Lee, and Dr. Shin Ae Park (College of Veterinary Medicine) Abstract: Groundbreaking research has been done on smart contact lenses, especially as a minimally invasive diagnostic platform and a drug delivery system. The eyes provide rich physiological and broad diagnostic information, making contact lens sensors a promising disease diagnostic tool. A smart contact lens, one such contact lens sensor, can quantify the concentrations of various biomolecules and electrolytes in ocular fluids and physical biomarkers of the eye, such as intraocular pressure (IOP). Continuous and non- or minimally invasive contact lens sensors can be directly utilized in a clinical or point-of-care setting. Here, we introduce the incorporation of contact lens sensors and their fabrication, sensitivity, power source, and readout mechanisms. The incorporation is to monitor glaucoma and conditions associated with eye health, such as dry eye syndrome and inflammation. The contact lens sensors fit seamlessly across different corneal curvatures and thicknesses in human eyes. The lens can also wirelessly capture the intraocular pressure by utilizing the principle of the mechanical deformation of the microfluidic channel under ambulatory conditions. Also, we will discuss the colorimetric ocular electrolyte tear fluid sensor to detect the color change of dry eye disease and inflammation. We assessed the in vitro biocompatibility, ex vivo functionality, and in vivo safety of the soft contact lens sensor. Zoom link: https://purdue-edu.zoom.us/j/97547949189<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Thurs., Nov. 30: Seminars in Hearing Research, 12:00 p.m., Nelson Hall, Room 1215. Cole Trent, PhD Student, SLHS will present "Discrimination of intact vs. elliptical sentences in CI-simulated speech." Abstract: Cochlear implant (CI) speech-recognition outcomes are influenced by various combinations of bottom-up and top-down factors. As such, there is substantial individual variability in CI outcomes. The purpose of this project is to assess elliptical speech as a tool for evaluating bottom-up perceptual acuity in CI users. Noise-vocoded sentence stimuli were presented to 10 normal-hearing (NH) listeners. Stimuli consisted of IEEE sentences that either maintained correct consonant place-of-articulation cues (Intact Speech) or contained consonant "ellipses" that ambiguated spectral cues to consonant place (Elliptical Speech). The "ellipses" replaced each key-word consonant with a new consonant maintaining the same manner and voicing of the original, but with an altered place feature. A concurrent neuroimaging measurement was conducted to estimate cortical activity in bilateral auditory cortex and dorsolateral prefrontal cortex via functional near-infrared spectroscopy (fNIRS). This project tested our hypotheses that: 1) NH participants will successfully detect ellipses in more favorable listening conditions but will be unable to detect ellipses under more degraded listening conditions, and 2) listeners will demonstrate differences in cortical activity in response to Intact vs Elliptical speech depending on the severity of the signal degradation. Preliminary results demonstrate that the detection of ellipses in speech is impacted by the spectral resolution of the signal, and this result is also reflected in listeners' cortical activity. These results have important implications for CI users whereby elliptical speech is a potential tool for isolating the quality of the bottom-up input from top-down processing of speech. This year's SHRP schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fogww.mj.am…> Titles and abstracts of all SHRP talks are here: https://purdue.edu/TPAN/hearing/shrp_abstracts<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fogww.mj.am…> Thurs., Nov. 30: BME Master's Defense Announcement for Nafisa Rafiq (M. Verma, advisor). Everyone is invited to attend the public presentation beginning at 3:00PM in ABE 5078. Title of Thesis Research: Design and development of a field deployable heating system for loop-mediated isothermal amplification. Committee Members: Dr. Mohit S. Verma (Chair), Dr. Jacqueline Linnes and Dr. Jon Schoonmaker Abstract: Nucleic acid testing has become a prominent method for rapid microbial detection. Unlike polymerase chain reaction (PCR), loop-mediated isothermal amplification (LAMP) is a simple method of nucleic acid amplification where the reaction can be performed at a constant temperature and the output provided in a colorimetric format. A transparent water bath heater is a desirable instrument to perform the heating and observe the visual results of nucleic acid amplification. However, existing methods of heating the water are not convenient for loading and unloading the nucleic acid samples. Here, we developed a field-deployable water bath heating device-an isothermal heater called IsoHeat for short-which is solely dedicated to performing LAMP reactions and can heat the water up to 85 °C (if needed). Using 3D-printing and LASER-cutting technology, we fabricated different parts of the device and mechanically assembled the parts to develop the entire device. Users can commence the heating by pressing the start button on the screen after entering the target temperature. Subsequently, the device heats up the water bath and maintains the target temperature through a PID algorithm-based control system. We demonstrate that IsoHeat can operate in environmental temperatures ranging from 5-33 °C and it can conduct LAMP reactions in a liquid format as well as in paper-based devices. IsoHeat is more efficient and user-friendly compared to a commercially available immersion-heating device, which is often used to perform LAMP reactions. This newly developed device would be helpful to detect pathogens conveniently in the field (e.g., at the point-of-care for human applications, on farms for plant and animal applications, and in production facilities for food safety applications). Thurs., Nov. 30: BME Master's Defense Announcement for LeRayah Neely-Brown (M. Ward and D. Umulis, co-advisors). Everyone is invited to attend the public presentation beginning at 3:00 PM in BRK 2001 and via Zoom. Title: Predicting General Vagal Nerve Activity via The Development of Biophysical A.I. Committee members: Dr. Matthew P. Ward (Primary Advisor), Dr. David Umulis (co-chair), and Dr. Calvin Eiber Abstract: The vagus nerve (VN) is a central nervous system (CNS) that mediates most of the parasympathetic functions of the autonomic nervous system. The axons of the human VN comprise a mix of unmyelinated and myelinated axons, where ~80% of the axons are unmyelinated C fibers (Havton et al., 2021). Understanding that the majority of VN axons are unmyelinated, there is a need to map the pathways of these axons to and from organs to understand their individual function(s) and whether C fiber morphology or signaling characteristics yield insights into their functions. The development of a machine learning model that detects and predicts the morphology of VN single fiber action potentials based on select fiber characteristics, e.g., diameter, myelination, and position within the VN, allows us to more readily categorize the nerve fibers with respect to their function(s). Additionally, the features of this machine learning model could help inform peripheral neuromodulation devices that aim to restore, replace, or augment one or more specific functions of the VN that have been lost due to injury, disease, or developmental abnormalities. We designed and trained four types of Multi-layer Perceptron Artificial Deep Neural Networks (MLP-ANN) with 10,000 rat abdominal vagal C-fibers simulated via the peripheral neural interface model ViNERS. We analyze the accuracy of each MLP-ANN's SFAP predictions by conducting normalized cross-correlation and morphology analyses with the ViNERS C-fiber SFAP counterparts. Our results showed that our best MLP predicted over 94% of the C-fiber SFAPs with strong normalized cross-correlation coefficients of 0.7 through 1 with the ViNERS SFAPs. Overall, this novel tool can use a C-fiber's biophysical characteristics (i.e. fiber diameter size, fiber position on the x/y axis, etc.) to predict C-fiber SFAP morphology. Zoom Link: https://purdue-edu.zoom.us/j/96803876511 <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Fri., Dec. 1: Indiana Life Sciences Conference - "Closing the Gap of Health Inequalities," 8:00 a.m. - 3:15 p.m., Roche Diagnostics, Indianapolis. [cid:image002.jpg@01DA211C.23823E30] [cid:image003.jpg@01DA211C.23823E30] Closing the Gap of Health Inequalities Friday, December 1 Roche Diagnostics, Indianapolis Addressing the persistent disparities in health and wellness among different populations is an issue that can't be ignored. While the healthcare cost implications are significant, the societal and economic implications are even more so. This conference will examine ongoing efforts to improve both the delivery of healthcare and health-related social factors like access to healthy foods, access to transportation and safe neighborhoods, which influence health outcomes. AGENDA 8:00-9:00am Registration & Breakfast 9:00-9:15am Welcome & Introduction 9:15-10:15am Opening Keynote- Defining Health Inequalities Paul K. Halvorsen, Professor & Founding Dean, Richard M. Fairbanks School of Public Health, Indiana University 10:15-10:30am Break 10:30am-12:00pm Panel- Provider Perspective & Initiatives Brownsyne Tucker Edmonds, M.D., Associate Professor of Obstetrics & Gynecology & Associate Dean for Health Equity Research, IU School of Medicine & VP Chief Health Equity Officer, IU Health Edmond Davis, Senior Director, Health Equity, Zimmer Biomet TBA 12:00-12:45pm Break for Lunch 12:45-1:30pm Luncheon Keynote- Snapshots of Ongoing Initiatives Paige Bingham, Director, Close the Gap Ariana McGee, Founder & CEO, Navigate Maternity Holly Wood, Senior Director, Health Equity Initiative, Purdue University TBA 1:30-3:00pm Panel- Payer Perspective & Initiative Antoniette Holt, Strategic Equity Officer & Division Director, Office of Minority Health, Indiana Department of Health Darryl Lockett, Health Equity Director, Anthem Indiana Medicaid Andy Vector, President of Benefits Consulting & Chief Growth Officer, MJ Insurance TBA 3:00-3:315pm Wrap-Up CLICK FOR MORE INFO & REGISTER NOW<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcl.s6.exc…> Button Text<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcl.s6.exc…> Mon., Dec. 4: BME PhD Defense Announcement for Conner C. Earl (C. Goergen, advisor). Everyone is invited to the public presentation beginning at 10:00am in MJIS 2001 or via Zoom. (10:00-11:00 am open portion, 11 am-12 pm closed portion)Title: Advanced Characterization of Cardiac Pathology Using 4D Medical Imaging. Thesis committee: Dr. Craig J. Goergen (Chair), Dr. Guang Lin, Dr. Vitaliy L. Rayz, Dr. Larry W. Markham, Dr. Jonathan H. Soslow Abstract: Cardiovascular disease remains the leading cause of death worldwide, highlighting the importance of improving cardiac imaging for early disease detection and treatment. While 3D and 4D imaging methods offer enhanced precision, their complexity necessitates accessible applications in research and clinical settings. This thesis introduces an advanced 4D kinematic analysis to evaluate Duchenne muscular dystrophy (DMD) cardiomyopathy, a progressive neuromuscular disorder with no cure, affecting approximately 1 in 5000 boys. Despite varied progression, the lack of standard imaging biomarkers impedes early detection or rapid-progressing DMD cardiomyopathy. Our novel 4D cardiac magnetic resonance imaging (CMR) analysis paradigm aims to comprehensively map left-ventricular kinematics, introducing innovative imaging biomarkers and computational methods for earlier and more accurate diagnosis of DMD. Our focus on myocardial strain biomarkers provides insights into early disease onset and progression, paving the way for multi-center studies to enhance treatment outcomes. Zoom link: https://purdue-edu.zoom.us/j/91371610129<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Wed., Dec. 6: BME-IBSC PhD Preliminary Exam Announcement for Brock Beauclair (R. Shi, advisor). Everyone is invited to attend the public presentation beginning at 2:00PM in Morgan (MRGN) 129. Research Title: Establishing an in vitro Model of Blast Induced Traumatic Brain Injury. Committee Members: Dr. Riyi Shi, major professor/committee chair, Dr. Scott Pluta, Dr. Edward Bartlett, Dr. Yunjie Tong Abstract: Traumatic brain injury (TBI) is a worldwide health issue. Increasing prevalence of blast-induced TBI (bTBI), a predominantly combat-related injury, is an alarming trend necessitating a better understanding of the associated pathogenesis to develop treatments. Further, most TBI/bTBI injuries are mild and undiagnosed, permitting secondary biochemical injuries to propagate beyond possible intervention. While a link between TBI/bTBI and chronic neurodegenerative diseases, such as Alzheimer's disease (AD), has been established, the mechanisms are not yet understood. Animal model studies have identified key pathologies, however their spatial and temporal resolution limits detailed investigations into cellular and molecular mechanisms underlying these complex injuries. Additional investigative tools are urgently needed to elucidate the mechanisms behind this immediate and long-term damage. While most in vitro methodologies offer the resolution required, few can visualize bTBI-induced cellular damage during injury, and subsequent biochemical injury. Therefore, we introduce "bTBI-on-a-Chip," an in vitro blast injury model, capable of simultaneous morphological, biochemical, and bioelectrical assessments during and after injury, with a series of targeted experiments to address this unmet need. We hypothesize that primary blast injury and secondary biochemical injury can be recapitulated in vitro for mechanistic studies into trauma-induced neurodegeneration. Further, we hypothesize that synaptic loss following bTBI can be demonstrated in our system and mitigated by pharmacological intervention, further linking bTBI and AD, and providing key insights into possible prevention strategies. Our goal is to facilitate translational discoveries by studying the mechanisms of bTBI to not only establish early diagnosis criteria, but suggest possible treatments to curtail post-trauma neurodegeneration. Thurs., Dec. 7: BME PhD Preliminary Exam Announcement for Sang Hoon Um (L. Green, advisor). Everyone is invited to attend the public presentation beginning at 2:30PM in MJIS 2001. Title: Retooling the membrane channel with DNA nanostructure for simultaneous and precise voltage recording. Committee members: Prof. Leopold Green (Chair), Prof. Fang Huang, Prof. Krishna Jayant, Prof. Chengde Mao (Chemistry) Abstract: Neuronal recording technologies have propelled neuroscience forward, facilitating the unraveling of neural functions across various spatiotemporal scales. Characterizing the membrane potential is crucial to understanding the brain's electrical activities and relationship with the structure and function of neural networks. However, scaling these recordings to measure across single neurons and nervous tissue simultaneously and integrating the measurements across various spatiotemporal scales are critical limitations. The recording limitations primarily result from the physical stress placed on delicate cell structures, preventing repeated membrane disturbance. Then, these limitations lead to the inherent incompatibility among various recording methods concerning their spatiotemporal scales. To address these challenges, we propose a novel application of DNA nanostructure as a versatile platform capable of simultaneously gathering and processing data from two representative recording techniques: patch-clamp electrophysiology and voltage-sensitive dye imaging. The engineered DNA nanodevice can be precisely inserted into live cell membranes using a patch pipette. Once inserted, the DNA nanopores create a synthetic ion channel for facilitating the acquisition of ground truth voltage measurements from individual neurons. Also, the incorporation of single Quantum Dots (QDs) within the DNA nanopore, allows for the recording of voltage signals from large populations of neurons. My research objectives are to (1) develop a reusable DNA nanopore to minimize membrane damage during successive recordings and (2) enhance signal detection by embedding QDs within the DNA nanopore, amplifying the Quantum-confined Stark Effect (QCSE). Achieving these aims will introduce an innovative method to harmonizing data acquisition from individual neurons through patch-clamp electrophysiology, which provides a reliable ground truth for voltage measurement in synthetic nanopores. Simultaneously, it will enable the concurrent recording of multiple neurons using QDs, ushering in an unprecedented era of multifaceted neuronal data acquisition. The expected outcomes of this work will enhance our comprehension of neuronal signaling processes, minimize disruptions to the cell membrane integrity for accurate interpretation of synaptic potential, and introduce an innovative approach to simultaneous and precise recording of neuronal signals across diverse spatiotemporal scales. Mon., Dec. 11: BME PhD Preliminary Exam Announcement for Grigorii Rudakov (T. Kinzer-Ursem and L. Green, co-advisors), 10:00 a.m., MJIS 1001. Title: "DNA Tetrahedron Design Optimization for Efficient Drug Delivery Through the Blood-Brain Barrier." This previously postponed preliminary exam has been re-scheduled for December 11. Advisory Committee: Leopold N. Green, Co-Chair; Tamara L. Kinzer-Ursem, Co-Chair; Chengde Mao; Gregory T. Knipp Abstract: Studying, treating, and mitigating the symptoms of Alzheimer's Disease and other Neurodegenerative Disorders is a big challenge due to the low Blood-Brain Barrier (BBB) permeability, which is highly selective on what can pass into the brain. In the proposed study, I aim to address the lack of a safe, efficient, and reliable brain drug delivery vehicle by optimizing the design of Tetrahedral DNA Nanomaterials (TDNs) to effectively deliver drugs through the BBB. Starting with two classical TDNs structures, I alter the design by changing the size, structure (one or two double-stranded DNA helices on the edges), and attached DNA aptamers for the receptor-medicated endocytosis pathway. I will study the influence of these factors on cellular uptake, stability of TDNs, toxicity, and potential delivery efficiency. I plan on testing the materials in vitro using primary mice cortical cells and human astrocytes Isogenic-induced Pluripotent Stem Cells, as well as in the human BBB in vitro model. To study the biodistribution and tissue toxicity, I will perform in vivo tests of the most promising TDNs designs in the C57BL/6 wild-type mouse model, harvest the tissues, and run histology analysis with Hematoxylin and Eosin Y stains. The TDNs concentration will be measured by using incorporated into the DNA strands cyanine 3 and 5 dyes fluorescence and the stability will be estimated by Fluorescence Resonance Energy Transfer measurements. After this work, I will have developed an effective, exceptionally biocompatible, and stable nanomaterial with great potential applications in drug delivery through BBB, brain imaging, and gene therapy. [cid:image004.png@01DA211C.23823E30] BME Weekly Research Seminars Week # Date Speaker Title Host Website 14 11/29/2023 Sarah Wiehe Jean and Jerry Bepko Professor of Pediatrics Indiana University School of Medicine George Wodicka https://medicine.iu.edu/faculty/16722/wiehe-sarah<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmedicine.…> 15 12/6/2023 Diane Wagner Associate Professor of Mechanical and Energy Engineering, IUPUI Deva Chan https://et.iupui.edu/people/wagnerdi Postdoctoral Fellow Opportunity - IUSM Emergency Medicine The laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include: (1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally. For additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Findiana.p…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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BME Master's Defense Announcement for LeRayah Neely-Brown (M. Ward and D. Umulis, co-advisors)
by May, Sandra M 27 Nov '23

27 Nov '23

BME Master's Defense Announcement for LeRayah Neely-Brown (M. Ward and D. Umulis, co-advisors) Everyone is invited to attend the public presentation beginning at 3:00 PM. Title: Predicting General Vagal Nerve Activity via The Development of Biophysical A.I. Date: Thursday, November 30 Time: 3:00 PM Location: BRK 2001/ Zoom Link: https://purdue-edu.zoom.us/j/96803876511 <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Committee members: Dr. Matthew P. Ward (Primary Advisor), Dr. David Umulis (co-chair), and Dr. Calvin Eiber Abstract: The vagus nerve (VN) is a central nervous system (CNS) that mediates most of the parasympathetic functions of the autonomic nervous system. The axons of the human VN comprise a mix of unmyelinated and myelinated axons, where ~80% of the axons are unmyelinated C fibers (Havton et al., 2021). Understanding that the majority of VN axons are unmyelinated, there is a need to map the pathways of these axons to and from organs to understand their individual function(s) and whether C fiber morphology or signaling characteristics yield insights into their functions. The development of a machine learning model that detects and predicts the morphology of VN single fiber action potentials based on select fiber characteristics, e.g., diameter, myelination, and position within the VN, allows us to more readily categorize the nerve fibers with respect to their function(s). Additionally, the features of this machine learning model could help inform peripheral neuromodulation devices that aim to restore, replace, or augment one or more specific functions of the VN that have been lost due to injury, disease, or developmental abnormalities. We designed and trained four types of Multi-layer Perceptron Artificial Deep Neural Networks (MLP-ANN) with 10,000 rat abdominal vagal C-fibers simulated via the peripheral neural interface model ViNERS. We analyze the accuracy of each MLP-ANN's SFAP predictions by conducting normalized cross-correlation and morphology analyses with the ViNERS C-fiber SFAP counterparts. Our results showed that our best MLP predicted over 94% of the C-fiber SFAPs with strong normalized cross-correlation coefficients of 0.7 through 1 with the ViNERS SFAPs. Overall, this novel tool can use a C-fiber's biophysical characteristics (i.e. fiber diameter size, fiber position on the x/y axis, etc.) to predict C-fiber SFAP morphology.

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Weldon Graduate Program Announcements November 22nd, 2023
by Siemers, Tammy R 22 Nov '23

22 Nov '23

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements November 22nd, 2023 * Career and Internship Opportunities * Computational Biosciences Postdoctoral Training Opportunity - University of Colorado Anschutz * PICR Career Development Seminar 11/27 * Yale University Virtual Postdoc Recruitment Event * Increasing BME 646 * Safety Procedures While Using Restroom * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Human-Centered AI Intern, ClearPoint<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Opex Intern, Teva Pharmaceuticals<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Intern, Biomedical Engineer, Getinge<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Manufacturing Engineering Intern, Cook Medical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Manufacturing Engineering Intern, Avalign Technologies<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Intern Biomarker Sciences, Gilead Sciences<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Summer 2024 Internship, EHS Manufacturing, Takeda<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Biological Data Analysis Intern, Summer 2024, Randstad<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.rands…> * Quality Assurance Intern, Summer 2024, Randstad<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.rands…> * Intern, Computational Pathology and AI, Mayo Clinic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Imaging Intern, Biomedical Engineering, Medpace<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Research Intern, Biomedical AI for Precision Health, Microsoft<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Quality Engineering Intern, Cook Medical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Biomedical Engineering Intern, Digital Healthcare Systems Group, Analog Devices<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * R&D Engineering Co-op, Fresenius Medical Care<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjobs.fmcn…> * Co-op Engineer, Automation Spring 2024, Boehringer Ingelheim<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjobs.boeh…> * Intern, Biomedical Engineer, Getinge<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Biomedical Engineering Intern, Advanced Development, Zoll<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> Postdoctoral Positions * Postdoctoral Associate, Bioengineering, Rice University<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Femdz.fa.u…> * Postdoc Machine Learning & Deep Learning, Biomedical Engineering, University of Illinois Chicago<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Postdoctoral Research Fellow, AI Interventional Applications, Siemens Healthineers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjobs.siem…> * NPA Website: https://careers.nationalpostdoc.org/jobs/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.n…> Full Time Positions * Biomedical Engineer, Leidos<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.l…> * Senior Design Engineer, SHL Medical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.shl-m…> * Engineer I/II Engineering Development Program, MicroVention Terumo<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.micro…> * Product Development, Digital Engineering, Senior Manager<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjobs.us.p…> * Clinical Field Engineer, BiVACOR<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Product Development Engineer II, Upper Extremity, Enovis Surgical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fenovis.wd…> * Senior Scientist, Computational Protein Engineer, A-Alpha Bio<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Test Engineer I, Surgical, Medtronic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Design Quality Engineer, Medical Device, Regeneron<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.r…> * Production Engineer I, Endotronix<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Biomedical Engineer, Veterans Affairs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.usajo…> * R&D Engineer, EBR Systems<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Quality Systems Engineer, ConMed<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.c…> * Associate Scientist III, Scientific Writer, Upstream Process Development, Catalent<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.c…> * Sr. Scientist/Bioengineer, Preclinical Dev, Pulse Biosciences<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Research Engineer, Imbed Biosciences<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fimbed-bio…> * Mechanical Engineer I, Abiomed<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Medical Device Innovative Product R&D Engineer, MZbio<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> (Chinese Mandarin Required) * Purdue Start-up Job Board<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurduefou…>—Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.a…>—Association for Clinical and Translational Science * Academic Careers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Facademicc…> * Doc Jobs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.docjo…>—Jobs beyond traditional clinical and academic roles Computational Biosciences Postdoctoral Training Opportunity - University of Colorado Anschutz See attached The Computational Bioscience Program (CPBS) at the University of Colorado Anschutz Medical Campus has openings for postdoctoral fellowships to start in early 2024. The fellowships are supported by a National Institutes of Health/National Library of Medicine T15 postdoctoral training grant. Through this opportunity, the CPBS aims to train computational biologists to achieve excellence in research, education, and service. Each postdoc will work with one or more program faculty, mainly located on the Anschutz Medical Campus but also at the Denver and Boulder campuses and at National Jewish Health. See the attached flyer for more details about the program and application instructions. For any questions, please contact CPBS(a)cuanschutz.edu<mailto:CPBS@cuanschutz.edu>. PICR Career Development Seminar 11/27 See attached The Career Development Series will be having the November seminar on Monday, November 27th. It will be a panel discussion by Valerie P. O’Brien, Ph.D., Kyle A. Cottrell, Ph.D., Ranjie Xu, Ph.D., Brian P. H. Metzger, Ph.D. Title: A Panel Discussion with Assistant Professors: Graduate School, Postdoc and Beyond Speaker: Valerie P. O’Brien, Ph.D., Kyle A. Cottrell, Ph.D., Ranjie Xu, Ph.D., Brian P. H. Metzger, Ph.D. Date and time: Monday, Nov. 27, 2023, 1-2pm Location: Drug Discovery (DRUG) Lobby Conference Room Lunch will be provided. More information on the talk can be found on the attached flyer. If you are planning to attend, please register here: https://purdue.ca1.qualtrics.com/jfe/form/SV_ac3Ahige3JMkquG<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> If you have any questions, please feel free to contact me (sstrasse(a)purdue.edu<mailto:sstrasse@purdue.edu>) or Dr. Jiang Yang (yang1491(a)purdue.edu<mailto:yang1491@purdue.edu>). Yale University Virtual Postdoc Recruitment Event Yale University’s Office for Postdoctoral Affairs is hosting its Virtual Postdoc Recruitment Event<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpostdocs.…> on February 15, 2024 from 1-4pm Eastern Time on Zoom and engages scholars interested in pursuing postdoctoral training at Yale University. Our goals are to support potential postdocs in their career exploration and identifying next steps, engage with potential postdocs from underrepresented and historically excluded groups, and increase awareness of the experience of and resources supporting Yale postdocs. Participants will have the opportunity to: · Meet with representatives from Yale resources for postdocs · Hear from and ask questions of current Yale faculty from a variety of disciplinary fields · Engage with current Yale postdocs in a virtual networking hour As part of the event, we will highlight current and future postdoctoral opportunities at Yale and how to follow up with the corresponding hiring departments and faculty. Please find full details on our webpage<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpostdocs.…>, including the registration form<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fyalesurve…>. Eligibility: We recommend participation by: current PhD, MD or MD-Phd students who are nearing completion of their degree and recent doctoral graduates (within 1-2 years of doctoral degree completion). While there is no citizenship requirement to participate, please note that some postdoctoral positions, because of the nature of their funding sources, are limited to those holding US citizenship. Increasing BME 646 See attached Charlie Bouman would like to increase the number of BME students that take his cross listed BME 646 Deep Learning course. To that end, he’s asked that we circulate the attached flier along with this link to his syllabus to our graduate students. https://engineering.purdue.edu/DeepLearn/ Safety Procedures While Using Restroom Out of an abundance of caution for all our staff, students and faculty, please make sure you are following the restroom safety guideline and procedures that are posted in the bathroom. This includes sitting on the countertops and standing on toilets as these are both falling hazards. Please make sure you are following the posted signs and are familiar with the Safety and Maintenance Policies in general for the building which you can find on the following website: https://engineering.purdue.edu/BME/AboutUs/Safety. Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. Nov. 24th Deadline to apply for URA Paid Summer Fellowships (Apply Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fura-hq.or…>) Nov. 27th Panel Discussion with Assistant Professors: Grad School, Postdoc, & Beyond (Register Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>) Dec 6th Purdue Grad WiE Pop-In (GWEN) Jan. 15th Deadline to apply for NOMIS-Gladstone Fellowship Program (Apply Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgladstone…>) Feb. 2nd Deadline to register for Graduate WiE Symposium (COE<https://www.purdue.edu/wiep/CurrentStudents/Graduate%20Women%20in%20Enginee…>) Feb. 13th 2024 Grad WiE Network Symposium (GWEN<https://www.purdue.edu/wiep/CurrentStudents/Graduate%20Women%20in%20Enginee…>) Feb. 15th Yale University Virtual Postdoc Recruitment Event (Yale<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fyalesurve…>) News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information – specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. – to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education BME Students (ONLY): Schedule appointments with me via BoilerConnect here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>. Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [cid:image001.png@01DA1D4D.E385E060]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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BME-IBSC PhD Preliminary Exam Announcement for Brock Beauclair (R. Shi, advisor)
by May, Sandra M 22 Nov '23

22 Nov '23

BME-IBSC PhD Preliminary Exam Announcement for Brock Beauclair (R. Shi, advisor) Everyone is invited to attend the public presentation beginning at 2:00PM. Research Title: Establishing an in vitro Model of Blast Induced Traumatic Brain Injury Date: December 6th Time: 2:00PM Location: Morgan (MRGN) 129 Committee Members: Dr. Riyi Shi, major professor/committee chair Dr. Scott Pluta Dr. Edward Bartlett Dr. Yunjie Tong Abstract: Traumatic brain injury (TBI) is a worldwide health issue. Increasing prevalence of blast-induced TBI (bTBI), a predominantly combat-related injury, is an alarming trend necessitating a better understanding of the associated pathogenesis to develop treatments. Further, most TBI/bTBI injuries are mild and undiagnosed, permitting secondary biochemical injuries to propagate beyond possible intervention. While a link between TBI/bTBI and chronic neurodegenerative diseases, such as Alzheimer’s disease (AD), has been established, the mechanisms are not yet understood. Animal model studies have identified key pathologies, however their spatial and temporal resolution limits detailed investigations into cellular and molecular mechanisms underlying these complex injuries. Additional investigative tools are urgently needed to elucidate the mechanisms behind this immediate and long-term damage. While most in vitro methodologies offer the resolution required, few can visualize bTBI-induced cellular damage during injury, and subsequent biochemical injury. Therefore, we introduce “bTBI-on-a-Chip,” an in vitro blast injury model, capable of simultaneous morphological, biochemical, and bioelectrical assessments during and after injury, with a series of targeted experiments to address this unmet need. We hypothesize that primary blast injury and secondary biochemical injury can be recapitulated in vitro for mechanistic studies into trauma-induced neurodegeneration. Further, we hypothesize that synaptic loss following bTBI can be demonstrated in our system and mitigated by pharmacological intervention, further linking bTBI and AD, and providing key insights into possible prevention strategies. Our goal is to facilitate translational discoveries by studying the mechanisms of bTBI to not only establish early diagnosis criteria, but suggest possible treatments to curtail post-trauma neurodegeneration.

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BME Master's Defense Announcement for Benjamin Dahl (T. Kinzer-Ursem, advisor)
by May, Sandra M 21 Nov '23

21 Nov '23

BME Master's Defense Announcement for Benjamin Dahl (T. Kinzer-Ursem, advisor) Everyone is invited to attend the public presentation beginning at 8:00am. Title: Fundamental and applied modeling in neurology: post-synaptic kinase anchoring and DNA amplification assays. Date: Thursday, November 30 Time: 8:00am Location: BRK 1001 Committee members: Dr. Tamara Kinzer-Ursem (chair), Dr. Elsje Pienaar, and Dr. Scott Bolton Abstract: Computational modeling has a broad range of applications in neuroscience, from discovering fundamental attributes of neuronal synaptic function to helping develop tools to fight neurodegenerative disorders. Here, we utilize computational modeling to investigate the dynamics of receptor phosphorylation that are important in regulating dynamic changes in synaptic strength. Within synapses, a thick network of proteins makes up a membrane-less structure called the post-synaptic density (PSD) in post-synaptic dendritic spines. The increased number and phosphorylation of glutamate receptors within the PSD is a hallmark of increased synaptic strength. A-kinase anchoring proteins (AKAPs) are important scaffolding proteins in the PSD that have been established to localize a number of regulatory enzymes such as protein kinase A, calcineurin, and phosphodiesterases near the cell membrane and glutamate receptor tails. However, it is still unclear what is their overall effect on glutamate receptor phosphorylation and trafficking. Here, a spatial stochastic computational model of AKAP and enzymatic binding partners in the PSD is developed and the dynamics of the system analyzed. Model results demonstrate the correlation between glutamate receptor tail phosphorylation and AKAP localization. By computational "knockdown" of AKAPs we are able to quantify their effect on glutamate receptor phosphorylation, investigate the role of spatial localization, and posit their potential impacts on LTP and synaptic plasticity.

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