November 2022 - Bmegradstudents-list

[Bmeroundtable-list] Save the Date: BME Welcome Back Ice Cream Social
by Siemers, Tammy R 10 Jul '23

10 Jul '23

Good Afternoon, We are once again going to host a Welcome Back (for some of you welcome to the Fall semester) Ice Cream Social on the first Friday of classes. Join us for some great conversation and yummy treats as we get the fall semester started. I will send a calendar invite to those that utilize that feature. Date: Friday, August 26th Time: 1-2 pm Location: MJIS South Lawn (rain location: MJIS 2001) I hope you consider joining us! Tammy Tammy Siemers She/Her Associate Director, Graduate Education Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Room change: BME PhD Preliminary Exam Announcement for Chun-Yi Chang (Chien-Chi Lin and Luis Solorio, Co-Chairs)
by May, Sandra M 30 Nov '22

30 Nov '22

*Please note the room change below.* BME PhD Preliminary Exam Announcement for Chun-Yi Chang (Chien-Chi Lin and Luis Solorio, Co-Chairs) Everyone is invited to attend the public presentation beginning at 10:00AM. Title: In situ generation of physiological gradients in cell-laden hydrogels Date: December 1, 2022 Time: 10:00AM Location: SL306C at IUPUI and via Zoom https://iu.zoom.us/j/87266126712 Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with 5-year survival rate of ~10%. A major hurdle to treating PDAC is the desmoplastic reaction in the tumor microenvironment (TME), which is a result of excess deposition of extracellular matrices (e.g., hyaluronic acid or HA) secreted by stromal cells. The desmoplastic reaction is a barrier blocking the therapeutics from entering the tumor, while allowing cancer cells to metastasize. To this end, we have developed a gelatin-based hydrogel system with biorthogonal click chemistries to mimic TME in PDAC. Gelatin was dually modified with norbornene and carbohydrazide (i.e., GelNB-CH) to form a primary gel network through thiol-norbornene chemistry and to allow dynamic stiffening via hydrazone click chemistry. The dynamic stiffening changed the cytokine and protein secretion of the encapsulated PDAC cells. Compared to gel stiffening with the bioinert control, matrix stiffening by oxidized HA (oHA) restored the spreading cell morphology and enhanced CD44 expression. To capture the heterogeneous ECM distribution in TME, we sought to create HA gradient in the hydrogel based on microporous annealed GelNB-CH microgels and the diffusion of oHA. The porous structure makes the annealed microgels more permeable for the diffusion of oHA than a nano-porous bulk gel. We expect the system can also be more permissive for cell protrusion or spheroid outgrowth. Future work will be focused on the EMT-related gene/protein expression and cell migration in response to the chemical and mechanical cues from the dynamic matrix.

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[Bmeroundtable-list] BME Monday Roundtable - Nov. 28, 2022
by Gelfand, Johanna K 28 Nov '22

28 Nov '22

[cid:image001.jpg@01D90313.DFA11C80] BME MONDAY ROUNDTABLE NOVEMBER 28, 2022 HEADS NOTE Hello everyone- welcome back to the home stretch of the semester. This week we have series of high impact special seminars in addition to our weekly Wednesday Seminar. Wednesday, Dr. Arnab Mukherjee will present on Engineering reporters for MRI, on Thursday- Dr. Chulhong Kim, Chair of Convergence IT engineering at Pohang University of Science and Technology (POSTECH), will present “Multi-modal imaging: Photoacoustic imaging plus more,” and on Friday, Dr. Tatiana Foroud, Executive Associate Dean for Research Affairs and Chair, Department of Medical & Molecular Genetics, Indiana University School of Medicine will present “Discovery to Translation in Neurodegenerative Disorders.” Dr. Foroud has been a key partner of the new Institute for Engineering in Medicine. Please see below for all detailed times and locations. Have a great week! UPCOMING IMPORTANT DATES Week of November 28 Mon., Nov. 28 through Fri., Dec. 2: BMES Food Drive. Join Food Finders and BMES to unite in helping to stock the food bank’s supply to ensure that our neighbors facing hunger have enough resources to care for their families this winter. Visit the drop-off box by MJIS 1021. Most needed items: 100% fruit juices, baking items, beans, boxed rice, potatoes, canned fish and meat, cereal, meals in a can/box, peanut butter, canned soups and stews. Mon., Nov. 28: BME Master's Defense Announcement for Aiswarya A Ramanujam (T. Kinzer-Ursem, advisor). Everyone is invited to attend the public presentation beginning at 9:30AM EST via Zoom. Title of thesis research: Assay Optimization for Point-Of-Care Detection of HIV Viral Load. Mon., Nov. 28: BME Master's Defense Announcement for Umm E Hani Abdullah (T. Kinzer-Ursem, advisor). Everyone is invited to attend the public presentation beginning at 11:30AM EST (Please note revised start time) in MJIS 2001 and via Zoom. Title: Deep brain stimulation in the Syngap1+/- mouse model of autism and intellectual disability. Tues., Nov. 29: BRAG Meeting for BME postdocs, visiting scientists and research staff, 2:00-3:00 p.m., MJIS 2001. Dr. Elsje Pienaar, Assistant Professor in BME will discuss “Strategies and challenges in learning about DEI”. The session will be in the format of a short presentation followed by Q&A, and the speaker has specifically asked us to send suggestions on topics, questions and thoughts ahead of time to best tailor the sessions to us. Please RSVP and email your suggestions to kejendal(a)purdue.edu. You are of course welcome with spontaneous questions as well! Welcome! Bring a postdoc friend! Wed., Nov. 30: Weldon School of Biomedical Engineering Distinguished Seminar, 9:30 a.m., MJIS 1001 or via Zoom. Arnab Mukherjee, Assistant Professor of Chemical Engineering at University of California, Santa Barbara will be presenting “Engineering protein reporters to image molecular events with magnetic resonance.” Wed., Nov. 30: BME Master's Defense Announcement for Alexandra Plummer (L. Solorio, advisor), 9:00 a.m., via Webex. Thesis Title: Collagen Matrix Modifications Impact on Matrix Microstructure and Mass Transport of Macromolecules. This defense is open only to those who have signed the Lilly NDA. Thesis Committee: Luis Solorio, Chair, Arezoo M. Ardekani, Julie C. Liu Webex link: https://purdue-student.webex.com/meet/plummera Wed., Nov. 30: BME PhD Defense Announcement for Joseph C. Muskat (V. Rayz and C. Goergen, Co-Chairs), 2:00 p.m., MRGN 121 and via Zoom. Everyone is invited to attend the public presentation. Dissertation Title: Application of Multiscale Hemodynamic Models to Explore the Action of Nitrite as a Vasodilator during Acute Cardiovascular Stress. Wed., Nov. 30: Seminar for Neurotrauma and Diseases, 4:00 p.m., via Zoom. Dr. Shihuan Kuang, Cancer Center Chair in Stem Cell Biology and Professor of Animal Sciences at Purdue University will present “Targeting stem cells in neuromuscular diseases.” Zoom link: https://bit.ly/3QN4YhL . This seminar series is sponsored by the Center for Paralysis Research and Plexon Neurotechnology Systems and is supported by the Purdue Institute for Integrative Neuroscience and Purdue Institute for Drug Discovery. Wed., Nov. 30: Frontiers in Biophysics Seminar, 1:30 p.m. via Zoom. Susan Buchanan of the NIDDK/NIH will present “Structural analysis of the Ton motor complex.” Register in advance at https://purdue.edu.zoom.us/meeting/register/UUtd-2rrTlqEt28s1D20iZPi-9RRDGj… Seminar series is co-sponsored by Structural and Computational Biology & Biophysics (SCBB) and the NIGMS-funded Molecular Biophysics Training Program (MBTP) in partnership with the Departments of Biomedical Engineering, Biochemistry, Physics and Astronomy, Chemistry, and Medicinal Chemistry and Molecular Pharmacology; and the following Institutes: PI4D, PCCR, and PIDD. Thurs., Dec. 1: Weldon School of Biomedical Engineering Special Seminar, 9:30 a.m., MJIS 2001 and via Zoom. Chulhong Kim, Department Chair of Convergence IT Engineering, Program Chair of Medical Science and Engineering and Mueunjae Chair of Electrical Engineering, Pohang University of Science and Technology, Korea, will present “Multi-modal imaging: Photoacoustic imaging plus more.” Thurs., Dec. 1: BME PhD Preliminary Exam Announcement for Chun-Yi Chang (Chien-Chi Lin and Luis Solorio, Co-Chairs), 10:00 a.m. in SL220 at IUPUI and via Zoom https://iu.zoom.us/j/87266126712. Title: In situ generation of physiological gradients in cell-laden hydrogels. Fri., Dec. 2: BME Special Seminar, 9:30 a.m., MJIS 2001. Tatiana Foroud, Executive Associate Dean for Research Affairs and Chair, Department of Medical & Molecular Genetics, Indiana University School of Medicine will present “Discovery to Translation in Neurodegenerative Disorders.” Fri., Dec. 2: BME Master's Defense Announcement for Shaheryar Khan (T. Kinzer-Ursem, advisor), 11:00 a.m., MJIS 2001. Thesis Title: Biophysical measurement of protein-protein interactions. This defense is open only to those who have signed the Lilly NDA. Thesis Committee: Tamara L. Kinzer-Ursem, Chair, Jean-Christophe Rochet, Karin F. K. Ejendal Fri., Dec. 2: Please make note of the grading deadline for all research students (grad & undergrad) and your Fall classes: Full Term (16 Weeks) and Second Eight-Week Session (meeting between October 19 and December 17) Grade entry begins at 8 a.m. December 2 and ends at 5 p.m. December 20. Faculty at West Lafayette not meeting the submission deadline for their reporting window will be required to submit via the Grade change workflow found in their myPurdue portal. Sun., Dec. 4: Deadline for submission for The Bilsland Dissertation Fellowship provides support for outstanding PhD candidates in their final year or semester of doctoral degree completion. The goal of the fellowship is to allow exceptional candidates to focus exclusively on finishing their dissertation. The Graduate School Fellowship Manual has additional details https://www.purdue.edu/gradschool/fellowship/fellowship-resources-for-staff… Note: Students in other schools outside of BME should follow those schools’ procedures. Holiday Updates Purdue University will be closed beginning Friday, December 23rd and will reopen on Tuesday, January 3rd. This means all offices, labs and buildings will be closed. This translates to no mail or package delivery, so (hopefully) you haven’t ordered anything perishable that will languish until your return on Tuesday, January 3rd.. We will also be closing and locking the student club room (MJIS 1051) over this time. Any food left in the refrigerator as of 5:00 p.m. on Thursday, December 22nd will be put in the trash. REMINDER: users of the Club Room on the 1st floor ARE RESPONSIBLE FOR CLEANING UP YOUR OWN MESSES. Lately, there has been an exponential increase in splattered food not being wiped out of the microwave, and other food debris left on the table surfaces, which has led to an influx of mice (and mice droppings) in this room. If you use the club room, YOU are responsible for cleaning up your mess. We don’t want to be forced to shut this area down, but if it continues to be left dirty, with unlabeled food in the refrigerator, we may have to take more drastic measures for everyone’s health safety. Researchers also need to make note that for the Winter Recess – The ordering deadline for research materials (animals, chemicals, drugs, etc.) will be noon on Wednesday, December 14, 2022, for delivery dates of December 19 – 22, 2022. There will be no deliveries of any kind on campus from December 22, 2022 through January 3, 2023. This same schedule will be followed for Drug Distribution Center orders. Please plan accordingly. Upcoming important deadlines and info. Tues., Dec. 6: BME PhD Preliminary Exam Announcement for Aditya Shanghavi (A. Sereno and B. Duerstock, co-advisors), 1:30 p.m. in MJIS 2001 and via Zoom. Title of presentation: A Study of Tremor in Parkinson’s Disease Using Signals From Wrist-Worn IMU Sensors Wed., Dec. 7: BME Distinguished Seminar Series, 9:30 a.m., MJIS 1001 and via Zoom. Henry H.N. Lam, Associate Head and Professor, Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology will present “Proteomics and its applications in antibiotic tolerance research.” Wed., Dec. 7: Frontiers in Biophysics Seminar, 1:30 p.m., MJIS 1001 and via Zoom. Cheng Zhu, Georgia Institute of Technology will present “Mechanosensing through immunoreceptors.” The seminar series is co-sponsored by Structural and Computational Biology & Biophysics in the Department of Biological Sciences and the NIGMS-funded Molecular Biophysics Training Program in partnership with the Departments of Biomedical Engineering, Biochemistry, Physics and Astronomy, Chemistry, and Medicinal Chemistry and Molecular Pharmacology and the following Institutes: PI4D, PCCR, and PIDD. Zoom link: https://purdue-edu.zoom.us/meeting/register/tJUtd-2rrTlqEt28s1D20iZPi-9RRDG… Thurs., Dec. 8: BME Faculty Coffee Chats for Grad Students, 2:00-3:00 p.m., MJIS 2041. Faculty host: Deva Chan. Potential discussion topics: AMA work-life, teaching & diversity statements, time management Thurs., Dec. 15 The BME Senior Design Expo will be from 3:30 - 5:30pm in MJIS 1097, 1001, and Atrium. There will be 24 projects presented followed by awards ceremony. Stay tuned for additional details. Fri., Dec. 23 through Mon., Jan. 2: Winter Recess. No classes, all university offices and buildings closed. Purdue will reopen Tuesday, January 3. PURDUE ADVERSE WINTER WEATHER POLICY If adverse weather conditions necessitate that a wind chill, snow or ice emergency be declared for the West Lafayette campus, special procedures pertaining to classes, operations, parking, pay and/or attendance will become effective. Jay Wasson, vice president for physical facilities and chief public safety officer, describes procedures for adverse winter weather in this memo<https://www.purdue.edu/ehps/emergency-preparedness/docs/adverse-winter-weat…>. Committee Updates Academic Programs Update Fri., Dec. 2: Please make note of the grading deadline for all research students (grad & undergrad) and your Fall classes: Full Term (16 Weeks) and Second Eight-Week Session (meeting between October 19 and December 17) Grade entry begins at 8 a.m. December 2 and ends at 5 p.m. December 20. Faculty at West Lafayette not meeting the submission deadline for their reporting window will be required to submit via the Grade change workflow found in their myPurdue portal. Undergraduate Programs Update The BME Senior Design Expo will be Thursday, December 15 from 3:30 - 5:30pm in MJIS 1097, 1001 and Atrium. There will be 24 projects presented followed by awards ceremony. Stay tuned for additional details. Graduate Office Update It is officially Three Minute Thesis (3MT®) competition season! To increase academic representation in our 3MT® competition, we are asking that West Lafayette graduate faculty members nominate talented graduate student(s) to represent their academic units. This is an exciting year to participate, as we have increased the cash prizes, which include $5,000 for first place, $3,000 for second place, and $2,000 for the People’s Choice Award winner. Nominees must be current Purdue graduate students studying at the West Lafayette campus. Each nominee will be contacted by Graduate School staff and encouraged to register for the competition. Nominations are not required for students to submit a draft video; they are simply intended to help the Graduate School identify and encouraged talented students to participate. The link to the nomination form below, as well as some additional information about the Graduate School’s 3MT® competition. Please email me, Allison Loy (Loy2(a)purdue.edu<mailto:Loy2@purdue.edu>), with any questions! Virtual 3MT® 2023 Nomination Form: * Nomination Deadline: January 13, 2023 https://purdue.ca1.qualtrics.com/jfe/form/SV_204r4KOtt2fUIbI What is 3MT®? Three Minute Thesis (3MT®) is a research communication competition that helps graduate students develop academic, presentation, and research communication skills so that they can effectively explain their research to a non-specialist audience. During each competition, graduate students will have three minutes to present a compelling discussion on their research topic, including its significance and relevance, to the general public. This is a fast-paced competition where the top 10 finalists compete by summarizing their two to three-plus years of research in only three minutes with only one slide. The cash awards for this year’s competition have been increased substantially, including $5,000 for first place, $3,000 for second place, and $2,000 for the People’s Choice Award winner. The first-place winner will also be invited to compete in the Midwestern Association of Graduate School’s (MAGS) annual 3MT® competition. 3MT® Timeline * Friday, February 10: Draft Video Submission Deadline – Learn more about making a draft video!<https://www.purdue.edu/gradschool/professional-development/documents/Virtua…> * Friday, February 24: Semifinalists Announced * Friday, March 3: Semi-Finals * Monday, March 6: Finalists Announced * Monday, April 10: 3MT® Rehearsal * Tuesday, April 11: 3MT® Competition Learn more about the Purdue University Graduate School’s 3MT® competition here: https://www.purdue.edu/gradschool/professional-development/competitions/3mt… BME Coffee Chats We are once again hosting are faculty coffee chats for grad students. Remember, we need attendance for this event to be successful so get these on your calendars today😊. These coffee chats will attempt to accomplish some priorities that have been shared with us by you: 1. First year students—what a great opportunity to find out more about other labs and find potential mentors for your qual committee. 2. Grad student professional development—to learn/ask/chat about topics of interest to the student either about research or other topics. 3. Increase faculty involvement with graduate students outside of their own lab. 4. Help build community between grad students. Here are the dates and faculty for fall: December: Date: December 8th Time: 2:00 pm-3:00 pm Location: MJIS 2041 Faculty host: Deva Chan Potential discussion topics: AMA work-life, teaching & diversity statements, time management Please plan to participate in as many as your schedule will allow. There will be free snacks and drinks included. Graduate Admissions Update Fall 2022 (Fall 2023 Admit Term) BME Graduate Admissions DateDATE Activity Now Research Areas create a plan and potentially agree on dates to meet ranking deadlines. December 19th—All Fellowship Nominations Due Dec 1 Complete applications due for priority admission and funding consideration Dec 2 Prescreening of eligibility of Purdue Doctoral and George Washington Carver sent to faculty Dec 2 Spreadsheet and applications posted to Engineering Intranet for Research Area and faculty review Dec 19 DUE: All Fellowship Nominations and Additional Invite Lists Dec 20 Grad office to process admission for all fellowship-nominated applicants to the Purdue Graduate School and any additional applicants you would like to admit from the open house invitation list. Dec 20 Tammy to send invitations to invited students to participate in our virtual open house. Jan 3 Deadline for students to respond to Open House RSVP (hotels released today). Jan 26 Agendas for all invited students due from faculty to Tammy and sent to student. Feb 2-4 Weldon School Visitation Days (Hybrid) Feb 8 Last chance for Research Areas / Faculty to remove students from fellowship consideration Feb 10 Fellowship offers announced and complete rankings list made available to BME faculty; BME Graduate Office will notify students by email (offer letters distributed as soon as signed by BME Head and COE Dean) Mar 10 DUE: All Master’s students to be decisioned as either admit, deny or hold Mar 31 Due: All PhD students to be decisioned as either admit, deny or hold April 15 Graduate applicant acceptance deadline Resources, attachments, further information BME Master's Defense Announcement for Aiswarya A Ramanujam (T. Kinzer-Ursem, advisor). Everyone is invited to attend the public presentation on Monday, November 28 beginning at 9:30AM EST via Zoom. Title of thesis research: Assay Optimization for Point-Of-Care Detection of HIV Viral Load. Zoom Link - https://purdue-edu.zoom.us/j/94260591743?pwd=U3c3ekVlM01FTkJCT1V6bDlRdXZmdz… Advisory committee: Dr. Tamara Kinzer-Ursem, Dr. Jacqueline Linnes, Dr. Robert V. Stahelin Abstract: As of 2021, 38.4 million people worldwide are living with HIV, with Eastern and Southern Africa having the highest prevalence. The efficacy of treatment is determined by identifying acute HIV infections and prompting early Antiretroviral therapy initiation to achieve viral suppression and reduce the risk of transmission. Existing rapid tests that detect host antibodies are affected by long seroconversions which allow the viruses to remain undetected until long after infection. On the contrary, highly sensitive NAAT-based assays, serving as the gold standard for detection are restricted by their long turnaround time and high cost of implementation thus, restricting their use in low resource settings. Further, drug resistance cases and patient non-compliance to treatment may lead to HIV progression to AIDS; therefore, effective viral load monitoring is a critical component in the HIV care continuum. To address the gaps in viral load monitoring and early HIV detection, I propose to develop assays for handheld self-test platforms to detect low concentrations of HIV via two different approaches: 1) I will optimize an existing NAAT-based assay to semi-quantitatively detect HIV particles that were spiked in clinical samples and 2) I will probe the binding kinetics of the HIV p24 - antibody interaction. Thus, I will lay the foundation for the development of a novel and highly sensitive p24 detection assay. Overall, this work will enable detection of early Acute HIV Infection detection as well as support PLHIV management, all while remaining connected to healthcare and provider support. BME Master's Defense Announcement for Umm E Hani Abdullah (T. Kinzer-Ursem, advisor). Everyone is invited to attend the public presentation on Monday, November 28 beginning at 11:30AM EST (Please note revised start time) in MJIS 2001 and via Zoom. Title: Deep brain stimulation in the Syngap1+/- mouse model of autism and intellectual disability. Thesis Committee: Dr. Tamara Kinzer-Ursem (Major Professor), Dr. Maria Dadarlat Makin, Dr. Karin Ejendal Abstract: Syngap1+/- haploinsufficiency is phenotypically characterized by autism spectrum disorder (ASD), intellectual disability (ID), and epilepsy. SynGAP as a protein, is also known as Synaptic Ras GTPase-activating protein, regulating the function in synapses. Treatment-resistant severe ASD in particular, presents concurrently with ID in 31% patients, where patients exhibit minimal speech formation, self-injurious behavior, and cognitive impairment. Previously, success in alleviating self-injurious behavior along with speech formation was demonstrated in adolescent patients undergoing deep brain stimulation (DBS) of the basolateral amygdala (BLA). In addition, SynGAP protein is an integral component of the post-synaptic density and its role in signaling pathway converges with other autism risk genes and consequently autism risk proteins. A critical gap exists in understanding how electrical stimulation as part of the Hebbian theory, can induce neuroplasticity. Therefore, we sought to develop a chronic DBS model in Syngap1+/- haploinsufficient mice that can be used to assess the behavior and proteomic correlates due to DBS in BLA. We optimized the DBS surgery and anesthesia requirements to ensure survival of Syngap1+/- mice as they are more susceptible to isoflurane anesthesia. Additionally, we optimized the DBS stimulation parameters in accordance with behavior responses from Syngap1+/- mice by performing multiple trials of DBS paremeters. These methods ensure attainment of local field potentials from Syngap1+/- mice – future directions include verifying the role of DBS in producing theta oscillations for the purposes of memory retrieval. Zoom link: https://purdue-edu.zoom.us/j/98616521806?pwd=clUrVkhVa1plTE5kSDduZlJIREZaQT… Weldon School of Biomedical Engineering Distinguished Seminar, Wed., Nov. 30, 9:30 a.m., MJIS 1001 or via Zoom. Arnab Mukherjee, Assistant Professor of Chemical Engineering at University of California, Santa Barbara will be presenting “Engineering protein reporters to image molecular events with magnetic resonance.” Abstract: Answers to some of the most pressing biological questions – such as how cancer cells metastasize, how neurons communicate, and how therapeutic cells find (or miss) their targets – are buried deep inside the body, beyond the reach of conventional optical reporter genes, such as fluorescent and bioluminescent proteins. Conversely, magnetic resonance imaging (MRI) is well-suited to imaging at any depth but lacks robust genetic reporters to visualize biological functions at the molecular and cellular levels. Our research is conducted at this somewhat unusual interface, where we engineer biological molecules, such as water channels, bacteriophages, and paramagnetic proteins, to guide the design of conceptually new biomolecular reporters for MRI. In this talk, I will highlight our recent efforts in this area by focusing on three examples of engineering proteins for MRI: (1) modulating water movement in and out of cells to image gene expression and protease activity, (2) reducing ambiguity in imaging studies by exploiting ligand-induced protein stabilization for background-free MRI, and (3) engineering antimicrobial immunity proteins into calcium biosensors. Bio: Arnab Mukherjee is an Assistant Professor of Chemical Engineering at the University of California, Santa Barbara, where his lab started in the summer of 2018. Prior to arriving at UCSB, he completed a Boswell fellowship in Molecular Engineering at Caltech and obtained his Ph.D. from the University of Illinois at Urbana-Champaign. The Mukherjee lab takes advantage of the unique physical and chemical properties of biological molecules to guide the design of conceptually new technologies for MRI, allowing the latter’s application in molecular-level studies in living organisms. Research in the Mukherjee group has been recognized with notable recent awards, including an Outstanding Young Investigator Award from the NIH (MIRA R35), a Discovery Award from the DoD, the NARSAD Young Investigator Award from the Brain & Behavior Research Foundation, and a Scialog Fellow in Advanced Bioimaging award. ~BME Faculty Host: Dr. Uzay Emir ~ NOTE: Students registered for the seminar are expected to attend in-person. Zoom: https://purdue-edu.zoom.us/j/7731446991?pwd=RHdkZTVnRkxTM3J3dnRvY1VLWTlYUT09 BME PhD Defense Announcement for Joseph C. Muskat (V. Rayz and C. Goergen, Co-Chairs), Wednesday, November 30, 2:00 p.m., MRGN 121 and via Zoom. Everyone is invited to attend the public presentation. Dissertation Title: Application of Multiscale Hemodynamic Models to Explore the Action of Nitrite as a Vasodilator during Acute Cardiovascular Stress. Advisory Committee: Vitaliy L. Rayz, Co-Chair, Craig J. Goergen, Co-Chair, Charles F. Babbs, Elsje Pienaar Abstract: The fluid dynamics of blood in the systemic circulation modulates production of nitric oxide (NO), a potent vasodilator. Non-invasive techniques such as the flow-mediated dilation (FMD) test and physiologic phenomena associated with autonomic stress induce hyperemia and subsequently higher levels of wall shear stress (WSS), stimulating endothelial nitric oxide synthase (eNOS) expression. In the current clinical practice, WSS–a key regulator of endothelial function–is commonly estimated assuming a parabolic velocity distribution, despite the evidence that the temporal changes of pulsatile blood flow over the cardiac cycle modulates vasodilation in mammals. This work investigates the effect of cardiovascular stress on local WSS distributions and the potential for accumulation of near-wall nitrite, the vasoactive storage form of NO in the bloodstream. The specific aims of the project are therefore as follows: 1) develop a reduced-order model of the major systemic vasculature at rest, during a flight-or-flight response, and under moderate levels of aerobic exercise; 2) derive a velocity-driven Womersley solution for pulsatile flow to support accurate estimation of pulsatile WSS in the clinical setting; and 3) quantify cumulative transport of nitrite in a multiscale model of bifurcating vasculature utilizing computational fluid dynamics (CFD). Development of these open-source, translatable methods enable accurate quantification of hemodynamics and species transport during cardiovascular stress. Results detailed herein extend our knowledge about hemodynamics of vascular homeostasis during autonomic stress, suggest a convergent evolutionary theory for having a complete circle of Willis, and potentially clarify reproducibility concerns associated with the FMD test. Zoom: https://purdue-edu.zoom.us/j/93964160161?pwd=Ui9Od2hTNU9sek04Y3gwTlZ2clZlZz… Weldon School of Biomedical Engineering Special Seminar, Thurs., Dec. 1, 9:30 a.m., MJIS 2001 and via Zoom. Chulhong Kim, Department Chair of Convergence IT Engineering, Program Chair of Medical Science and Engineering, POSTECH Young Distinguished Professor and Mueunjae Chair Professor of Electrical Engineering, Convergence IT Engineering, and Mechanical Engineering, Director of Medical Device Innovation Center at Pohang University of Science and Technology (POSTECH), Korea, will present “Multi-modal imaging: Photoacoustic imaging plus more.” Abstract: Trans-energy imaging modalities have been significantly explored to overcome existing problems in conventional imaging modalities with respect to spatial/temporal resolutions, penetration depth, signal-to-noise ratio, contrast, and so on. Among them, photoacoustic imaging, an emerging hybrid modality that can provide strong endogenous and exogenous optical absorption contrasts with high ultrasonic spatial resolution, has overcome the fundamental depth limitation while keeping the spatial resolution. The image resolution, as well as the maximum imaging depth, is scalable with ultrasonic frequency within the reach of diffuse photons. In this presentation, the following topics will be discussed; (1) multiscale and multiparametric trans-energy imaging systems, (2) novel deep-learning powered image processing, (3) recent clinical study results, and (4) efforts to commercialization. Bio: Dr. Chulhong Kim studied for his Ph.D. degree and postdoctoral training under Prof. Lihong Wang at Washington University in St. Louis. He has published 200 peer-reviewed journal articles (Nat. Nanotech., Nat. Mat., Nat. BME, PNAS, Light Science & Applications, Advanced Science, Laser & Photonics Reviews, Cancer Research, Radiology, IEEE T. Medical Imaging, etc). He has currently served as a Section Editor of Photoacoustics Journal, an Associate Editor of IEEE Transactions on Medical Imaging, a Topical Editor of IEEE ACCESS, and an Editorial Board Member of Scientific Reports, Applied Science, Sensors, etc. ~BME Faculty Host: Dr. Young Kim ~ Zoom link: https://purdue-edu.zoom.us/j/91214862961?pwd=T1ZiaytxZ0ZCM1F3c1paZVJBQkRYQT… BME PhD Preliminary Exam Announcement for Chun-Yi Chang (Chien-Chi Lin and Luis Solorio, Co-Chairs), Thurs., Dec. 1, 10:00 a.m. in SL220 at IUPUI and via Zoom https://iu.zoom.us/j/87266126712. Title: In situ generation of physiological gradients in cell-laden hydrogels. Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with 5-year survival rate of ~10%. A major hurdle to treating PDAC is the desmoplastic reaction in the tumor microenvironment (TME), which is a result of excess deposition of extracellular matrices (e.g., hyaluronic acid or HA) secreted by stromal cells. The desmoplastic reaction is a barrier blocking the therapeutics from entering the tumor, while allowing cancer cells to metastasize. To this end, we have developed a gelatin-based hydrogel system with biorthogonal click chemistries to mimic TME in PDAC. Gelatin was dually modified with norbornene and carbohydrazide (i.e., GelNB-CH) to form a primary gel network through thiol-norbornene chemistry and to allow dynamic stiffening via hydrazone click chemistry. The dynamic stiffening changed the cytokine and protein secretion of the encapsulated PDAC cells. Compared to gel stiffening with the bioinert control, matrix stiffening by oxidized HA (oHA) restored the spreading cell morphology and enhanced CD44 expression. To capture the heterogeneous ECM distribution in TME, we sought to create HA gradient in the hydrogel based on microporous annealed GelNB-CH microgels and the diffusion of oHA. The porous structure makes the annealed microgels more permeable for the diffusion of oHA than a nano-porous bulk gel. We expect the system can also be more permissive for cell protrusion or spheroid outgrowth. Future work will be focused on the EMT-related gene/protein expression and cell migration in response to the chemical and mechanical cues from the dynamic matrix. BME Special Seminar, Fri., Dec. 2, 9:30 a.m., MJIS 2001. Tatiana Foroud, Executive Associate Dean for Research Affairs and Chair, Department of Medical & Molecular Genetics, Indiana University School of Medicine will present “Discovery to Translation in Neurodegenerative Disorders.” Abstract: Alzheimer’s disease and Parkinson’s disease are the two most common neurodegenerative disorders. The frequency of both has increased with the aging of the world’s population. Genetics has elucidated key mechanisms of disease risk which are now being targeted for novel therapeutics. Ameliorating symptoms once an individual has been diagnosed is likely too late to dramatically alter disease course. Current goals are to develop approaches to identify those at greatest risk and identify biomarkers which can then be used in trials to not only delay but potentially deter disease onset. This presentation will review the genetics underlying these disorders and discuss ongoing approaches to prepare for future trials in prodromal individuals. Bio: Tatiana Foroud, PhD<https://medicine.iu.edu/faculty/276/foroud-tatiana>, is the Executive Associate Dean for Research Affairs, the August M. Watanabe Professor for Medical Research, and remains as the Joe C. Christian Professor and Chair of the Department of Medical and Molecular Genetics. Dr. Foroud is also a Distinguished Professor and a Chancellor’s Professor, IUPUI. Over the course of her more than 25 years with IU School of Medicine, Dr. Foroud has been actively involved in the genetics of neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease as well as studies of alcoholism and fetal alcohol spectrum disorders. A statistical geneticist by training, she leads several large NIH-funded biorepositories focused on the development of effective biomarkers of disease onset and progression. ~BME Host: Craig Goergen~ The Bilsland Dissertation Fellowship provides support for outstanding PhD candidates in their final year or semester of doctoral degree completion. The goal of the fellowship is to allow exceptional candidates to focus exclusively on finishing their dissertation. The Graduate School Fellowship Manual has additional details https://www.purdue.edu/gradschool/fellowship/fellowship-resources-for-staff… Note: Students in other schools outside of BME should follow those schools procedures. Due Date: Sunday, December 4th (tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>) Student Eligibility * At the time of nomination, students must have 1) completed their preliminary exam or, 2) submitted the paperwork scheduling their preliminary exam for a date before May 31. * Students who will complete their defense prior to September 1, 2023, are not eligible. * Students who need less than 1 semester of support are not eligible. * Nominees must be outstanding engineering PhD students. * The following criteria will be used to rank the nominees: * Merit. Includes publications, conference presentations, GPA etc. * Funding need. * Good citizen of the School and College. Includes service. * Career promise. Includes leadership, innovation, readiness and potential to make an impact. Application Package Should Include the following in one PDF: * A letter (limit 2 pages) from the major professor nominating the student and confirming that the student’s expected graduation date. This can be sent separately if the student is providing the rest of the information. * The student’s thesis abstract, * A copy of the preliminary examination paperwork (to confirm the student is on track to graduate next year), * The student’s CV, * A copy of the student’s most recent transcript – graduate work only. Salary & Usage: * This fellowship includes $28,600 annual salary, tuition remission, medical insurance premium contribution, and coverage of most fees. Engineering differential fee is not covered. * Bilsland Fellowships are administered as assistantships. It is expected that job duties will contribute to the completion of the student’s dissertation. * This year’s Bilsland allocation may be used Summer 2023, Fall 2023, Spring 2024, or Summer 2024. * No additional work appointments may be added, but faculty may (and perhaps must; depending on our minimum salary requirement which may be set in BME) increase the salary or provide additional funds as scholarships, etc. * The fellowship is to be awarded for the full 12 months or until the student graduates, whichever comes first. * Fellowship recipients who graduate before the completion of the fellowship or otherwise stop the fellowship before the full 12 month duration forfeit any remaining funds. * If Bilsland Fellows do not graduate as expected this could hurt our funding allocation from the Graduate School, so please only nominate students you truly expect to graduate and are truly in their final year. The announcement will go out to the students as well. Please let me know if you have any questions. BME PhD Preliminary Exam Announcement for Aditya Shanghavi (A. Sereno and B. Duerstock, co-advisors), Tues., Dec. 6, 1:30 p.m. in MJIS 2001 and via Zoom. Title of presentation: A Study of Tremor in Parkinson’s Disease Using Signals From Wrist-Worn IMU Sensors. Advisory Committee: Anne B. Sereno, Co-Chair; Bradley S. Duerstock, Co-Chair; Craig J. Goergen; Satyajit S. Ambike Abstract: Parkinson’s Disease (PD) is the second most common neurodegenerative disorder with resting tremor (RT) being its most common motor symptom. The literature has revealed that the need for lengthy, clinic-based subjective evaluation by trained neurologists of treatment effects in PD creates challenges for monitoring the progression of the disease and titrating optimal therapeutic therapies. Preliminary studies have shown that features of a power spectral density (PSD) analysis of wrist velocity and acceleration can be used as objective, reliable, and sensitive detectors of RT. Replacing the neurologist’s judgement on the progression of the disease is not feasible, yet some aspects of tracking the disorder and treatment may profit from more frequent remote sensor measurements. There is an opportunity to improve patient-care by introducing non-invasive, sensor-based objective measurements of RT using wrist movements that can aid the neurologist with the MS- UPDRS evaluation in the diagnostic process. Success in objectively quantifying RT with such a method would allow physicians to more frequently and remotely monitor patients to change the treatment plan as needed to reduce the severity of harmful side effects of PD medication. Virtual Link: https://purdue-edu.zoom.us/j/4520252995 BME Distinguished Seminar Series, Wed., Dec. 7, 9:30 a.m., MJIS 1001 and via Zoom. Henry H.N. Lam, Associate Head and Professor, Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology will present “Proteomics and its applications in antibiotic tolerance research” on Wednesday, December 7, at 9:30 a.m. in MJIS 1001 and via Zoom. Abstract: Proteomics has witnessed rapid technological advances in the past decade and a half. Despite its obvious promise, proteomics still poses a considerable barrier of entry for the average life scientist, and the adoption of this powerful technology across different areas has been uneven. In this talk, I will present two rather distinct stories that have the same underlying goal, namely, to suggest a roadmap for proteomics to become truly ubiquitous in all life science research. The first is in computational method development. Proteomics is a prototypical "Big Data" field, but it may be surprising to some that despite the rapid accumulation of LC-MS/MS data in public repositories, for the most part all these data have not been meaningfully reused. This unfortunate situation can be traced to how we are used to analyze data in proteomics in isolation without prior knowledge, and how we store and organize the data. I will discuss our ongoing efforts to change this by organizing proteomics data by spectral similarity, and our vision for a simpler and more user-friendly way to analyze proteomics data. The second is in the application of proteomics to an important problem in microbiology -- the fascinating but annoying ability of bacterial pathogens to survive antibiotic treatment. Antibiotic tolerance, defined as the ability of a bacterial population to outlive lethal doses of antibiotics in a non-proliferating and non-specific way, is distinct from, and less understood, than antibiotic resistance. I will discuss our recent work in applying proteomics and adaptive laboratory evolution to map the "tolerome" (the set of genes and proteins that affect tolerance) in two organisms, Escherichia coli and Staphylococcus aureus, and some hard-learned lessons of how to reduce distraction when dealing with hundreds of differentially expressed proteins. In doing so, I hope to show an example of what proteomics can and cannot do, and how it enables one to make progress towards addressing open-ended biological questions. Bio: Prof. Henry Lam is currently Professor in the Department of Chemical and Biological Engineering in the Hong Kong University of Science and Technology (HKUST). He obtained his Ph. D. (Chemical Engineering) from Massachusetts Institute of Technology in 2005, and received postdoctoral training in the Aebersold group at the Institute for Systems Biology (ISB) in Seattle, Washington. At ISB, he participated in developing data analysis workflows in the then-nascent field of proteomics, some of which have become standard practice today. He has a longstanding interest in making the powerful technology of proteomics more reliable and more accessible to life scientists. Current research in his group focuses on method development in proteomics and metabolomics, particularly in algorithm design and data organization, and applications of proteomics in biological research, particularly in microbiology. ~BME Host: Young Kim~ NOTE:Students registered for the seminar are expected to attend in-person. Zoom link: https://purdue-edu.zoom.us/j/7731446991?pwd=RHdkZTVnRkxTM3J3dnRvY1VLWTlYUT09 -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Revised start time: BME Master's Defense Announcement for Umm E Hani Abdullah (T. Kinzer-Ursem, advisor)
by May, Sandra M 23 Nov '22

23 Nov '22

*Please note the revised start time.* BME Master's Defense Announcement for Umm E Hani Abdullah (T. Kinzer-Ursem, advisor) Everyone is invited to attend the public presentation beginning at 11:30AM EST. Title: Deep brain stimulation in the Syngap1+/- mouse model of autism and intellectual disability Date: November 28, 2022 Time: 11:30AM EST Location: MJIS 2001 and Zoom (meeting info below*) Thesis Committee: Dr. Tamara Kinzer-Ursem (Major Professor) Dr. Maria Dadarlat Makin Dr. Karin Ejendal Abstract: Syngap1+/- haploinsufficiency is phenotypically characterized by autism spectrum disorder (ASD), intellectual disability (ID), and epilepsy. SynGAP as a protein, is also known as Synaptic Ras GTPase-activating protein, regulating the function in synapses. Treatment-resistant severe ASD in particular, presents concurrently with ID in 31% patients, where patients exhibit minimal speech formation, self-injurious behavior, and cognitive impairment. Previously, success in alleviating self-injurious behavior along with speech formation was demonstrated in adolescent patients undergoing deep brain stimulation (DBS) of the basolateral amygdala (BLA). In addition, SynGAP protein is an integral component of the post-synaptic density and its role in signaling pathway converges with other autism risk genes and consequently autism risk proteins. A critical gap exists in understanding how electrical stimulation as part of the Hebbian theory, can induce neuroplasticity. Therefore, we sought to develop a chronic DBS model in Syngap1+/- haploinsufficient mice that can be used to assess the behavior and proteomic correlates due to DBS in BLA. We optimized the DBS surgery and anesthesia requirements to ensure survival of Syngap1+/- mice as they are more susceptible to isoflurane anesthesia. Additionally, we optimized the DBS stimulation parameters in accordance with behavior responses from Syngap1+/- mice by performing multiple trials of DBS paremeters. These methods ensure attainment of local field potentials from Syngap1+/- mice - future directions include verifying the role of DBS in producing theta oscillations for the purposes of memory retrieval. *Hani Abdullah is inviting you to a scheduled Zoom meeting. Topic: Hani Abdullah's Master's Defense Time: Nov 28, 2022 11:30 AM America/Indiana/Indianapolis Join Zoom Meeting https://purdue-edu.zoom.us/j/98616521806?pwd=clUrVkhVa1plTE5kSDduZlJIREZaQT… Meeting ID: 986 1652 1806 Passcode: 185740 One tap mobile +13092053325,,98616521806#,,,,*185740# US +13126266799,,98616521806#,,,,*185740# US (Chicago) Dial by your location +1 309 205 3325 US +1 312 626 6799 US (Chicago) +1 646 558 8656 US (New York) +1 646 931 3860 US +1 301 715 8592 US (Washington DC) +1 305 224 1968 US +1 253 205 0468 US +1 253 215 8782 US (Tacoma) +1 346 248 7799 US (Houston) +1 360 209 5623 US +1 386 347 5053 US +1 507 473 4847 US +1 564 217 2000 US +1 669 444 9171 US +1 669 900 6833 US (San Jose) +1 689 278 1000 US +1 719 359 4580 US Meeting ID: 986 1652 1806 Passcode: 185740 Find your local number: https://purdue-edu.zoom.us/u/addulYR6hX

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BME PhD Preliminary Exam Announcement for Aditya Shanghavi (A. Sereno and B. Duerstock, co-advisors)
by May, Sandra M 23 Nov '22

23 Nov '22

BME PhD Preliminary Exam Announcement for Aditya Shanghavi (A. Sereno and B. Duerstock, co-advisors) Everyone is invited to attend the public presentation beginning at 1:30 pm. Title: A Study of Tremor in Parkinson's Disease Using Signals From Wrist-Worn IMU Sensors Date: 12/06/2022 Time: 1:30 pm Location: MJIS 2001 Virtual Link: https://purdue-edu.zoom.us/j/4520252995 Advisory Committee: Anne B. Sereno, Co-Chair Bradley S. Duerstock, Co-Chair Craig J. Goergen Satyajit S. Ambike Abstract: Parkinson's Disease (PD) is the second most common neurodegenerative disorder with resting tremor (RT) being its most common motor symptom. The literature has revealed that the need for lengthy, clinic-based subjective evaluation by trained neurologists of treatment effects in PD creates challenges for monitoring the progression of the disease and titrating optimal therapeutic therapies. Preliminary studies have shown that features of a power spectral density (PSD) analysis of wrist velocity and acceleration can be used as objective, reliable, and sensitive detectors of RT. Replacing the neurologist's judgement on the progression of the disease is not feasible, yet some aspects of tracking the disorder and treatment may profit from more frequent remote sensor measurements. There is an opportunity to improve patient-care by introducing non-invasive, sensor-based objective measurements of RT using wrist movements that can aid the neurologist with the MS- UPDRS evaluation in the diagnostic process. Success in objectively quantifying RT with such a method would allow physicians to more frequently and remotely monitor patients to change the treatment plan as needed to reduce the severity of harmful side effects of PD medication.

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BME PhD Preliminary Exam Announcement for Chun-Yi Chang (Chien-Chi Lin and Luis Solorio, Co-Chairs)
by May, Sandra M 21 Nov '22

21 Nov '22

BME PhD Preliminary Exam Announcement for Chun-Yi Chang (Chien-Chi Lin and Luis Solorio, Co-Chairs) Everyone is invited to attend the public presentation beginning at 10:00AM. Title: In situ generation of physiological gradients in cell-laden hydrogels Date: December 1, 2022 Time: 10:00AM Location: SL220 at IUPUI and via Zoom https://iu.zoom.us/j/87266126712 Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with 5-year survival rate of ~10%. A major hurdle to treating PDAC is the desmoplastic reaction in the tumor microenvironment (TME), which is a result of excess deposition of extracellular matrices (e.g., hyaluronic acid or HA) secreted by stromal cells. The desmoplastic reaction is a barrier blocking the therapeutics from entering the tumor, while allowing cancer cells to metastasize. To this end, we have developed a gelatin-based hydrogel system with biorthogonal click chemistries to mimic TME in PDAC. Gelatin was dually modified with norbornene and carbohydrazide (i.e., GelNB-CH) to form a primary gel network through thiol-norbornene chemistry and to allow dynamic stiffening via hydrazone click chemistry. The dynamic stiffening changed the cytokine and protein secretion of the encapsulated PDAC cells. Compared to gel stiffening with the bioinert control, matrix stiffening by oxidized HA (oHA) restored the spreading cell morphology and enhanced CD44 expression. To capture the heterogeneous ECM distribution in TME, we sought to create HA gradient in the hydrogel based on microporous annealed GelNB-CH microgels and the diffusion of oHA. The porous structure makes the annealed microgels more permeable for the diffusion of oHA than a nano-porous bulk gel. We expect the system can also be more permissive for cell protrusion or spheroid outgrowth. Future work will be focused on the EMT-related gene/protein expression and cell migration in response to the chemical and mechanical cues from the dynamic matrix.

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[Bmeroundtable-list] BME Monday Roundtable, 11/21/22
by Gelfand, Johanna K 21 Nov '22

21 Nov '22

[cid:image002.jpg@01D8FD89.07569010] BME MONDAY ROUNDTABLE NOVEMBER 21, 2022 UPCOMING IMPORTANT DATES Week of November 21 Mon., Nov. 21: IU Center for Diabetes and Metabolic Diseases Research Seminar Series, 12:00 p.m., R4-101 (Indianapolis) and via Zoom. Paul J. Rozance, MD, Professor of Pediatrics and Frederick C. Battaglia Chair in Neonatology Research at the University of Colorado School of Medicine will present “Understanding the in-Utero Origins of Diabetes in Placental Insufficiency and Intrauterine Growth Restriction.” Zoom link: https://iu.zoom.us/j/83951671092?pwd=WC9GNTJaVTRVcEIyako4cHMvN2FXZz09 Tues., Nov. 22: BME PhD Defense Announcement for Tanmaye Nallan Chakravarthula (N. Alves and S. Harbin, co-chairs), 12:00 p.m., via Zoom. Title: Modulating plasmin activity with multivalent inhibitors for drug delivery applications Thurs., Nov. 24 and Fri., Nov. 25: Thanksgiving Holiday. No classes, all university offices and buildings closed. Holiday Updates Purdue University will be closed on Thursday and Friday (Nov. 24-25). This means all offices, labs and buildings will be closed. This translates to no mail or package delivery, so (hopefully) you haven’t ordered anything perishable that will languish until your return on Monday, Nov. 28. We will also be closing and locking the student club room (MJIS 1051) over this time. Any food left in the refrigerator as of 5:00 p.m. on Wednesday, November 23rd will be put in the trash. That being said – users of the Club Room on the 1st floor ARE RESPONSIBLE FOR CLEANING UP YOUR OWN MESSES. Lately, there has been an exponential increase in splattered food not being wiped out of the microwave, and other food debris left on the table surfaces, which has led to an influx of mice (and mice droppings) in this room. If you use the club room, YOU are responsible for cleaning up your mess. We don’t want to be forced to shut this area down, but if it continues to be left dirty, with unlabeled food in the refrigerator, we may have to take more drastic measures for everyone’s health safety. We will similarly be closing the club room over Winter Break (December 23 – January 3). Researchers also need to make note that for the Winter Recess – The ordering deadline for research materials (animals, chemicals, drugs, etc.) will be noon on Wednesday, December 14, 2022, for delivery dates of December 19 – 22, 2022. There will be no deliveries of any kind on campus from December 22, 2022 through January 3, 2023. This same schedule will be followed for Drug Distribution Center orders. Please plan accordingly. Upcoming important deadlines and info. Mon., Nov. 28: BME Master's Defense Announcement for Aiswarya A Ramanujam (T. Kinzer-Ursem, advisor). Everyone is invited to attend the public presentation beginning at 9:30AM EST via Zoom. Title of thesis research: Assay Optimization for Point-Of-Care Detection of HIV Viral Load. Mon., Nov. 28: BME Master's Defense Announcement for Umm E Hani Abdullah (T. Kinzer-Ursem, advisor). Everyone is invited to attend the public presentation beginning at 11:00AM EST in MJIS 2001 and via Zoom. Title: Deep brain stimulation in the Syngap1+/- mouse model of autism and intellectual disability. Tues., Nov. 29: BRAG Meeting for BME postdocs, visiting scientists and research staff, 2:00-3:00 p.m., MJIS 2001. Dr. Elsje Pienaar, Assistant Professor in BME will discuss “Strategies and challenges in learning about DEI”. The session will be in the format of a short presentation followed by Q&A, and the speaker has specifically asked us to send suggestions on topics, questions and thoughts ahead of time to best tailor the sessions to us. Please RSVP and email your suggestions to kejendal(a)purdue.edu. You are of course welcome with spontaneous questions as well! Welcome! Bring a postdoc friend! Wed., Nov. 30: Weldon School of Biomedical Engineering Distinguished Seminar, 9:30 a.m., MJIS 1001 or via Zoom. Arnab Mukherjee, Assistant Professor of Chemical Engineering at University of California, Santa Barbara will be presenting “Engineering protein reporters to image molecular events with magnetic resonance.” Wed., Nov. 30: BME Master's Defense Announcement for Alexandra Plummer (L. Solorio, advisor), 9:00 a.m., via Webex. Thesis Title: Collagen Matrix Modifications Impact on Matrix Microstructure and Mass Transport of Macromolecules. This defense is open only to those who have signed the Lilly NDA. Thesis Committee: Luis Solorio, Chair, Arezoo M. Ardekani, Julie C. Liu Webex link: https://purdue-student.webex.com/meet/plummera Wed., Nov. 30: BME PhD Defense Announcement for Joseph C. Muskat (V. Rayz and C. Goergen, Co-Chairs), 2:00 p.m., MRGN 121 and via Zoom. Everyone is invited to attend the public presentation. Dissertation Title: Application of Multiscale Hemodynamic Models to Explore the Action of Nitrite as a Vasodilator during Acute Cardiovascular Stress. Wed., Nov. 30: Seminar for Neurotrauma and Diseases, 4:00 p.m., via Zoom. Dr. Shihuan Kuang, Cancer Center Chair in Stem Cell Biology and Professor of Animal Sciences at Purdue University will present “Targeting stem cells in neuromuscular diseases.” Zoom link: https://bit.ly/3QN4YhL . This seminar series is sponsored by the Center for Paralysis Research and Plexon Neurotechnology Systems and is supported by the Purdue Institute for Integrative Neuroscience and Purdue Institute for Drug Discovery. Wed., Nov. 30: Frontiers in Biophysics Seminar, 1:30 p.m. via Zoom. Susan Buchanan of the NIDDK/NIH will present “Structural analysis of the Ton motor complex.” Register in advance at https://purdue.edu.zoom.us/meeting/register/UUtd-2rrTlqEt28s1D20iZPi-9RRDGj… Seminar series is co-sponsored by Structural and Computational Biology & Biophysics (SCBB) and the NIGMS-funded Molecular Biophysics Training Program (MBTP) in partnership with the Departments of Biomedical Engineering, Biochemistry, Physics and Astronomy, Chemistry, and Medicinal Chemistry and Molecular Pharmacology; and the following Institutes: PI4D, PCCR, and PIDD. Thurs., Dec. 1: Weldon School of Biomedical Engineering Special Seminar, 9:30 a.m., MJIS 2001 and via Zoom. Chulhong Kim, Department Chair of Convergence IT Engineering, Program Chair of Medical Science and Engineering and Mueunjae Chair of Electrical Engineering, Pohang University of Science and Technology, Korea, will present “Multi-modal imaging: Photoacoustic imaging plus more.” Fri., Dec. 2: BME Master's Defense Announcement for Shaheryar Khan (T. Kinzer-Ursem, advisor), 11:00 a.m., MJIS 2001. Thesis Title: Biophysical measurement of protein-protein interactions. This defense is open only to those who have signed the Lilly NDA. Thesis Committee: Tamara L. Kinzer-Ursem, Chair, Jean-Christophe Rochet, Karin F. K. Ejendal Fri., Dec. 2: Please make note of the grading deadline for all research students (grad & undergrad) and your Fall classes: Full Term (16 Weeks) and Second Eight-Week Session (meeting between October 19 and December 17) Grade entry begins at 8 a.m. December 2 and ends at 5 p.m. December 20. Faculty at West Lafayette not meeting the submission deadline for their reporting window will be required to submit via the Grade change workflow found in their myPurdue portal. Sun., Dec. 4: Deadline for submission for The Bilsland Dissertation Fellowship provides support for outstanding PhD candidates in their final year or semester of doctoral degree completion. The goal of the fellowship is to allow exceptional candidates to focus exclusively on finishing their dissertation. The Graduate School Fellowship Manual has additional details https://www.purdue.edu/gradschool/fellowship/fellowship-resources-for-staff… Note: Students in other schools outside of BME should follow those schools’ procedures. Wed., Dec. 7: BME Distinguished Seminar Series, 9:30 a.m., MJIS 1001 and via Zoom. Henry H.N. Lam, Associate Head and Professor, Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology will present “Proteomics and its applications in antibiotic tolerance research.” Wed., Dec. 7: Frontiers in Biophysics Seminar, 1:30 p.m., MJIS 1001 and via Zoom. Cheng Zhu, Georgia Institute of Technology will present “Mechanosensing through immunoreceptors.” The seminar series is co-sponsored by Structural and Computational Biology & Biophysics in the Department of Biological Sciences and the NIGMS-funded Molecular Biophysics Training Program in partnership with the Departments of Biomedical Engineering, Biochemistry, Physics and Astronomy, Chemistry, and Medicinal Chemistry and Molecular Pharmacology and the following Institutes: PI4D, PCCR, and PIDD. Zoom link: https://purdue-edu.zoom.us/meeting/register/tJUtd-2rrTlqEt28s1D20iZPi-9RRDG… Thurs., Dec. 8: BME Faculty Coffee Chats for Grad Students, 2:00-3:00 p.m., MJIS 2041. Faculty host: Deva Chan. Potential discussion topics: AMA work-life, teaching & diversity statements, time management Thurs., Dec. 15 The BME Senior Design Expo will be from 3:30 - 5:30pm in MJIS 1097, 1001, and Atrium. There will be 24 projects presented followed by awards ceremony. Stay tuned for additional details. Fri., Dec. 23 through Mon., Jan. 2: Winter Recess. No classes, all university offices and buildings closed. Purdue will reopen Tuesday, January 3. PURDUE ADVERSE WINTER WEATHER POLICY If adverse weather conditions necessitate that a wind chill, snow or ice emergency be declared for the West Lafayette campus, special procedures pertaining to classes, operations, parking, pay and/or attendance will become effective. Jay Wasson, vice president for physical facilities and chief public safety officer, describes procedures for adverse winter weather in this memo<https://www.purdue.edu/ehps/emergency-preparedness/docs/adverse-winter-weat…>. Committee Updates Academic Programs Update Fri., Dec. 2: Please make note of the grading deadline for all research students (grad & undergrad) and your Fall classes: Full Term (16 Weeks) and Second Eight-Week Session (meeting between October 19 and December 17) Grade entry begins at 8 a.m. December 2 and ends at 5 p.m. December 20. Faculty at West Lafayette not meeting the submission deadline for their reporting window will be required to submit via the Grade change workflow found in their myPurdue portal. Undergraduate Programs Update The BME Senior Design Expo will be Thursday, December 15 from 3:30 - 5:30pm in MJIS 1097, 1001 and Atrium. There will be 24 projects presented followed by awards ceremony. Stay tuned for additional details. Graduate Office Update The Bilsland Dissertation Fellowship provides support for outstanding PhD candidates in their final year or semester of doctoral degree completion. The goal of the fellowship is to allow exceptional candidates to focus exclusively on finishing their dissertation. The Graduate School Fellowship Manual has additional details https://www.purdue.edu/gradschool/fellowship/fellowship-resources-for-staff… Note: Students in other schools outside of BME should follow those schools procedures. Due Date: Sunday, December 4th (tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>) It is officially Three Minute Thesis (3MT®) competition season! To increase academic representation in our 3MT® competition, we are asking that West Lafayette graduate faculty members nominate talented graduate student(s) to represent their academic units. This is an exciting year to participate, as we have increased the cash prizes, which include $5,000 for first place, $3,000 for second place, and $2,000 for the People’s Choice Award winner. Nominees must be current Purdue graduate students studying at the West Lafayette campus. Each nominee will be contacted by Graduate School staff and encouraged to register for the competition. Nominations are not required for students to submit a draft video; they are simply intended to help the Graduate School identify and encouraged talented students to participate. The link to the nomination form below, as well as some additional information about the Graduate School’s 3MT® competition. Please email me, Allison Loy (Loy2(a)purdue.edu<mailto:Loy2@purdue.edu>), with any questions! Virtual 3MT® 2023 Nomination Form: * Nomination Deadline: January 13, 2023 https://purdue.ca1.qualtrics.com/jfe/form/SV_204r4KOtt2fUIbI What is 3MT®? Three Minute Thesis (3MT®) is a research communication competition that helps graduate students develop academic, presentation, and research communication skills so that they can effectively explain their research to a non-specialist audience. During each competition, graduate students will have three minutes to present a compelling discussion on their research topic, including its significance and relevance, to the general public. This is a fast-paced competition where the top 10 finalists compete by summarizing their two to three-plus years of research in only three minutes with only one slide. The cash awards for this year’s competition have been increased substantially, including $5,000 for first place, $3,000 for second place, and $2,000 for the People’s Choice Award winner. The first-place winner will also be invited to compete in the Midwestern Association of Graduate School’s (MAGS) annual 3MT® competition. 3MT® Timeline * Friday, February 10: Draft Video Submission Deadline – Learn more about making a draft video!<https://www.purdue.edu/gradschool/professional-development/documents/Virtua…> * Friday, February 24: Semifinalists Announced * Friday, March 3: Semi-Finals * Monday, March 6: Finalists Announced * Monday, April 10: 3MT® Rehearsal * Tuesday, April 11: 3MT® Competition Learn more about the Purdue University Graduate School’s 3MT® competition here: https://www.purdue.edu/gradschool/professional-development/competitions/3mt… BME Coffee Chats We are once again hosting are faculty coffee chats for grad students. Remember, we need attendance for this event to be successful so get these on your calendars today😊. These coffee chats will attempt to accomplish some priorities that have been shared with us by you: 1. First year students—what a great opportunity to find out more about other labs and find potential mentors for your qual committee. 2. Grad student professional development—to learn/ask/chat about topics of interest to the student either about research or other topics. 3. Increase faculty involvement with graduate students outside of their own lab. 4. Help build community between grad students. Here are the dates and faculty for fall: December: Date: December 8th Time: 2:00 pm-3:00 pm Location: MJIS 2041 Faculty host: Deva Chan Potential discussion topics: AMA work-life, teaching & diversity statements, time management Please plan to participate in as many as your schedule will allow. There will be free snacks and drinks included. Graduate Admissions Update Fall 2022 (Fall 2023 Admit Term) BME Graduate Admissions DateDATE Activity Now Research Areas create a plan and potentially agree on dates to meet ranking deadlines. December 19th—All Fellowship Nominations Due Dec 1 Complete applications due for priority admission and funding consideration Dec 2 Prescreening of eligibility of Purdue Doctoral and George Washington Carver sent to faculty Dec 2 Spreadsheet and applications posted to Engineering Intranet for Research Area and faculty review Dec 19 DUE: All Fellowship Nominations and Additional Invite Lists Dec 20 Grad office to process admission for all fellowship-nominated applicants to the Purdue Graduate School and any additional applicants you would like to admit from the open house invitation list. Dec 20 Tammy to send invitations to invited students to participate in our virtual open house. Jan 3 Deadline for students to respond to Open House RSVP (hotels released today). Jan 26 Agendas for all invited students due from faculty to Tammy and sent to student. Feb 2-4 Weldon School Visitation Days (Hybrid) Feb 8 Last chance for Research Areas / Faculty to remove students from fellowship consideration Feb 10 Fellowship offers announced and complete rankings list made available to BME faculty; BME Graduate Office will notify students by email (offer letters distributed as soon as signed by BME Head and COE Dean) Mar 10 DUE: All Master’s students to be decisioned as either admit, deny or hold Mar 31 Due: All PhD students to be decisioned as either admit, deny or hold April 15 Graduate applicant acceptance deadline Resources, attachments, further information BME PhD Defense Announcement for Tanmaye Nallan Chakravarthula (N. Alves and S. Harbin, co-chairs), Tues., Nov. 22, 12:00 p.m., via Zoom. Title: Modulating plasmin activity with multivalent inhibitors for drug delivery applications. Zoom: https://purdue-edu.zoom.us/j/95332317333?pwd=dXRvMlAwMG5SLy85L2VlQVZ6Uis0Zz… Meeting ID: 953 3231 7333 Passcode: 582479 Thesis Committee: Dr. Nathan J. Alves (Advisor, Co-Chair), Dr. Sherry L. Voytik-Harbin (Co-Chair), Dr. David H. Thompson (Member), Dr. Luis Solorio (Member) Abstract: Plasmin is a crucial enzyme for blood clot digestion and for maintaining hemostatic balance. There is emerging interest in applying multivalency to achieve strong and highly controlled enzyme inhibition. Benzamidine is a competitive inhibitor of plasmin’s active site whereas tranexamic acid (TXA) is an FDA-approved inhibitor that blocks plasmin’s kringle domains. Herein, benzamidine and TXA were utilized to synthesize three classes of multivalent inhibitors (i) Multivalent benzamidines (ii) Multivalent TXAs, and (iii) Hetero-multivalent molecules having both benzamidine and TXA to evaluate their plasmin inhibition. These inhibitors were synthesized using amine-reactive chemistry, purified using RP-HPLC and confirmed with Mass Spectrometry. Inhibition assays were performed to assess inhibition potency by determining Ki values (inhibition constants). Lower Ki values indicate stronger inhibition. With multivalent benzamidine derivatives, it was observed that changing valency and linker length substantially impacted inhibition and resulted in Ki values ranging from 2.1 to 1,395 µM. Multivalent benzamidine inhibitors with higher valencies and shorter linker lengths exhibited stronger inhibition. Multivalent TXAs of valencies 1 to 16 were also tested and they exhibited Ki values varying from 2.5 to 21,000 µM indicating up to 8,400-fold improvement in inhibition due to valency. It was found that monovalent TXA, primarily a kringle inhibitor, was converted into a stronger active site inhibitor by multivalency. With hetero-bivalent TXA-dPEG36-AMB, simultaneous binding of benzamidine to the active site and TXA to the kringle domains was achieved to attain improved inhibition. These results indicate that multivalency can modulate plasmin inhibition and can significantly improve the potency of inhibitors. BME Master's Defense Announcement for Aiswarya A Ramanujam (T. Kinzer-Ursem, advisor). Everyone is invited to attend the public presentation on Monday, November 28 beginning at 9:30AM EST via Zoom. Title of thesis research: Assay Optimization for Point-Of-Care Detection of HIV Viral Load. Zoom Link - https://purdue-edu.zoom.us/j/94260591743?pwd=U3c3ekVlM01FTkJCT1V6bDlRdXZmdz… Advisory committee: Dr. Tamara Kinzer-Ursem, Dr. Jacqueline Linnes, Dr. Robert V. Stahelin Abstract: As of 2021, 38.4 million people worldwide are living with HIV, with Eastern and Southern Africa having the highest prevalence. The efficacy of treatment is determined by identifying acute HIV infections and prompting early Antiretroviral therapy initiation to achieve viral suppression and reduce the risk of transmission. Existing rapid tests that detect host antibodies are affected by long seroconversions which allow the viruses to remain undetected until long after infection. On the contrary, highly sensitive NAAT-based assays, serving as the gold standard for detection are restricted by their long turnaround time and high cost of implementation thus, restricting their use in low resource settings. Further, drug resistance cases and patient non-compliance to treatment may lead to HIV progression to AIDS; therefore, effective viral load monitoring is a critical component in the HIV care continuum. To address the gaps in viral load monitoring and early HIV detection, I propose to develop assays for handheld self-test platforms to detect low concentrations of HIV via two different approaches: 1) I will optimize an existing NAAT-based assay to semi-quantitatively detect HIV particles that were spiked in clinical samples and 2) I will probe the binding kinetics of the HIV p24 - antibody interaction. Thus, I will lay the foundation for the development of a novel and highly sensitive p24 detection assay. Overall, this work will enable detection of early Acute HIV Infection detection as well as support PLHIV management, all while remaining connected to healthcare and provider support. BME Master's Defense Announcement for Umm E Hani Abdullah (T. Kinzer-Ursem, advisor). Everyone is invited to attend the public presentation on Monday, November 28 beginning at 11:00AM EST in MJIS 2001 and via Zoom. Title: Deep brain stimulation in the Syngap1+/- mouse model of autism and intellectual disability. Thesis Committee: Dr. Tamara Kinzer-Ursem (Major Professor), Dr. Maria Dadarlat Makin, Dr. Karin Ejendal Abstract: Syngap1+/- haploinsufficiency is phenotypically characterized by autism spectrum disorder (ASD), intellectual disability (ID), and epilepsy. SynGAP as a protein, is also known as Synaptic Ras GTPase-activating protein, regulating the function in synapses. Treatment-resistant severe ASD in particular, presents concurrently with ID in 31% patients, where patients exhibit minimal speech formation, self-injurious behavior, and cognitive impairment. Previously, success in alleviating self-injurious behavior along with speech formation was demonstrated in adolescent patients undergoing deep brain stimulation (DBS) of the basolateral amygdala (BLA). In addition, SynGAP protein is an integral component of the post-synaptic density and its role in signaling pathway converges with other autism risk genes and consequently autism risk proteins. A critical gap exists in understanding how electrical stimulation as part of the Hebbian theory, can induce neuroplasticity. Therefore, we sought to develop a chronic DBS model in Syngap1+/- haploinsufficient mice that can be used to assess the behavior and proteomic correlates due to DBS in BLA. We optimized the DBS surgery and anesthesia requirements to ensure survival of Syngap1+/- mice as they are more susceptible to isoflurane anesthesia. Additionally, we optimized the DBS stimulation parameters in accordance with behavior responses from Syngap1+/- mice by performing multiple trials of DBS paremeters. These methods ensure attainment of local field potentials from Syngap1+/- mice – future directions include verifying the role of DBS in producing theta oscillations for the purposes of memory retrieval. Zoom link: https://purdue-edu.zoom.us/j/98616521806?pwd=clUrVkhVa1plTE5kSDduZlJIREZaQT… Weldon School of Biomedical Engineering Distinguished Seminar, Wed., Nov. 30, 9:30 a.m., MJIS 1001 or via Zoom. Arnab Mukherjee, Assistant Professor of Chemical Engineering at University of California, Santa Barbara will be presenting “Engineering protein reporters to image molecular events with magnetic resonance.” Abstract: Answers to some of the most pressing biological questions – such as how cancer cells metastasize, how neurons communicate, and how therapeutic cells find (or miss) their targets – are buried deep inside the body, beyond the reach of conventional optical reporter genes, such as fluorescent and bioluminescent proteins. Conversely, magnetic resonance imaging (MRI) is well-suited to imaging at any depth but lacks robust genetic reporters to visualize biological functions at the molecular and cellular levels. Our research is conducted at this somewhat unusual interface, where we engineer biological molecules, such as water channels, bacteriophages, and paramagnetic proteins, to guide the design of conceptually new biomolecular reporters for MRI. In this talk, I will highlight our recent efforts in this area by focusing on three examples of engineering proteins for MRI: (1) modulating water movement in and out of cells to image gene expression and protease activity, (2) reducing ambiguity in imaging studies by exploiting ligand-induced protein stabilization for background-free MRI, and (3) engineering antimicrobial immunity proteins into calcium biosensors. Bio: Arnab Mukherjee is an Assistant Professor of Chemical Engineering at the University of California, Santa Barbara, where his lab started in the summer of 2018. Prior to arriving at UCSB, he completed a Boswell fellowship in Molecular Engineering at Caltech and obtained his Ph.D. from the University of Illinois at Urbana-Champaign. The Mukherjee lab takes advantage of the unique physical and chemical properties of biological molecules to guide the design of conceptually new technologies for MRI, allowing the latter’s application in molecular-level studies in living organisms. Research in the Mukherjee group has been recognized with notable recent awards, including an Outstanding Young Investigator Award from the NIH (MIRA R35), a Discovery Award from the DoD, the NARSAD Young Investigator Award from the Brain & Behavior Research Foundation, and a Scialog Fellow in Advanced Bioimaging award. ~BME Faculty Host: Dr. Uzay Emir ~ NOTE: Students registered for the seminar are expected to attend in-person. Zoom: https://purdue-edu.zoom.us/j/7731446991?pwd=RHdkZTVnRkxTM3J3dnRvY1VLWTlYUT09 BME PhD Defense Announcement for Joseph C. Muskat (V. Rayz and C. Goergen, Co-Chairs), Wednesday, November 30, 2:00 p.m., MRGN 121 and via Zoom. Everyone is invited to attend the public presentation. Dissertation Title: Application of Multiscale Hemodynamic Models to Explore the Action of Nitrite as a Vasodilator during Acute Cardiovascular Stress. Advisory Committee: Vitaliy L. Rayz, Co-Chair, Craig J. Goergen, Co-Chair, Charles F. Babbs, Elsje Pienaar Abstract: The fluid dynamics of blood in the systemic circulation modulates production of nitric oxide (NO), a potent vasodilator. Non-invasive techniques such as the flow-mediated dilation (FMD) test and physiologic phenomena associated with autonomic stress induce hyperemia and subsequently higher levels of wall shear stress (WSS), stimulating endothelial nitric oxide synthase (eNOS) expression. In the current clinical practice, WSS–a key regulator of endothelial function–is commonly estimated assuming a parabolic velocity distribution, despite the evidence that the temporal changes of pulsatile blood flow over the cardiac cycle modulates vasodilation in mammals. This work investigates the effect of cardiovascular stress on local WSS distributions and the potential for accumulation of near-wall nitrite, the vasoactive storage form of NO in the bloodstream. The specific aims of the project are therefore as follows: 1) develop a reduced-order model of the major systemic vasculature at rest, during a flight-or-flight response, and under moderate levels of aerobic exercise; 2) derive a velocity-driven Womersley solution for pulsatile flow to support accurate estimation of pulsatile WSS in the clinical setting; and 3) quantify cumulative transport of nitrite in a multiscale model of bifurcating vasculature utilizing computational fluid dynamics (CFD). Development of these open-source, translatable methods enable accurate quantification of hemodynamics and species transport during cardiovascular stress. Results detailed herein extend our knowledge about hemodynamics of vascular homeostasis during autonomic stress, suggest a convergent evolutionary theory for having a complete circle of Willis, and potentially clarify reproducibility concerns associated with the FMD test. Zoom: https://purdue-edu.zoom.us/j/93964160161?pwd=Ui9Od2hTNU9sek04Y3gwTlZ2clZlZz… Weldon School of Biomedical Engineering Special Seminar, Thurs., Dec. 1, 9:30 a.m., MJIS 2001 and via Zoom. Chulhong Kim, Department Chair of Convergence IT Engineering, Program Chair of Medical Science and Engineering, POSTECH Young Distinguished Professor and Mueunjae Chair Professor of Electrical Engineering, Convergence IT Engineering, and Mechanical Engineering, Director of Medical Device Innovation Center at Pohang University of Science and Technology (POSTECH), Korea, will present “Multi-modal imaging: Photoacoustic imaging plus more.” Abstract: Trans-energy imaging modalities have been significantly explored to overcome existing problems in conventional imaging modalities with respect to spatial/temporal resolutions, penetration depth, signal-to-noise ratio, contrast, and so on. Among them, photoacoustic imaging, an emerging hybrid modality that can provide strong endogenous and exogenous optical absorption contrasts with high ultrasonic spatial resolution, has overcome the fundamental depth limitation while keeping the spatial resolution. The image resolution, as well as the maximum imaging depth, is scalable with ultrasonic frequency within the reach of diffuse photons. In this presentation, the following topics will be discussed; (1) multiscale and multiparametric trans-energy imaging systems, (2) novel deep-learning powered image processing, (3) recent clinical study results, and (4) efforts to commercialization. Bio: Dr. Chulhong Kim studied for his Ph.D. degree and postdoctoral training under Prof. Lihong Wang at Washington University in St. Louis. He has published 200 peer-reviewed journal articles (Nat. Nanotech., Nat. Mat., Nat. BME, PNAS, Light Science & Applications, Advanced Science, Laser & Photonics Reviews, Cancer Research, Radiology, IEEE T. Medical Imaging, etc). He has currently served as a Section Editor of Photoacoustics Journal, an Associate Editor of IEEE Transactions on Medical Imaging, a Topical Editor of IEEE ACCESS, and an Editorial Board Member of Scientific Reports, Applied Science, Sensors, etc. ~BME Faculty Host: Dr. Young Kim ~ Zoom link: https://purdue-edu.zoom.us/j/91214862961?pwd=T1ZiaytxZ0ZCM1F3c1paZVJBQkRYQT… The Bilsland Dissertation Fellowship provides support for outstanding PhD candidates in their final year or semester of doctoral degree completion. The goal of the fellowship is to allow exceptional candidates to focus exclusively on finishing their dissertation. The Graduate School Fellowship Manual has additional details https://www.purdue.edu/gradschool/fellowship/fellowship-resources-for-staff… Note: Students in other schools outside of BME should follow those schools procedures. Due Date: Sunday, December 4th (tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>) Student Eligibility * At the time of nomination, students must have 1) completed their preliminary exam or, 2) submitted the paperwork scheduling their preliminary exam for a date before May 31. * Students who will complete their defense prior to September 1, 2023, are not eligible. * Students who need less than 1 semester of support are not eligible. * Nominees must be outstanding engineering PhD students. * The following criteria will be used to rank the nominees: * Merit. Includes publications, conference presentations, GPA etc. * Funding need. * Good citizen of the School and College. Includes service. * Career promise. Includes leadership, innovation, readiness and potential to make an impact. Application Package Should Include the following in one PDF: * A letter (limit 2 pages) from the major professor nominating the student and confirming that the student’s expected graduation date. This can be sent separately if the student is providing the rest of the information. * The student’s thesis abstract, * A copy of the preliminary examination paperwork (to confirm the student is on track to graduate next year), * The student’s CV, * A copy of the student’s most recent transcript – graduate work only. Salary & Usage: * This fellowship includes $28,600 annual salary, tuition remission, medical insurance premium contribution, and coverage of most fees. Engineering differential fee is not covered. * Bilsland Fellowships are administered as assistantships. It is expected that job duties will contribute to the completion of the student’s dissertation. * This year’s Bilsland allocation may be used Summer 2023, Fall 2023, Spring 2024, or Summer 2024. * No additional work appointments may be added, but faculty may (and perhaps must; depending on our minimum salary requirement which may be set in BME) increase the salary or provide additional funds as scholarships, etc. * The fellowship is to be awarded for the full 12 months or until the student graduates, whichever comes first. * Fellowship recipients who graduate before the completion of the fellowship or otherwise stop the fellowship before the full 12 month duration forfeit any remaining funds. * If Bilsland Fellows do not graduate as expected this could hurt our funding allocation from the Graduate School, so please only nominate students you truly expect to graduate and are truly in their final year. The announcement will go out to the students as well. Please let me know if you have any questions. Wed., Dec. 7: BME Distinguished Seminar Series, 9:30 a.m., MJIS 1001 and via Zoom. Henry H.N. Lam, Associate Head and Professor, Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology will present “Proteomics and its applications in antibiotic tolerance research” on Wednesday, December 7, at 9:30 a.m. in MJIS 1001 and via Zoom. Abstract: Proteomics has witnessed rapid technological advances in the past decade and a half. Despite its obvious promise, proteomics still poses a considerable barrier of entry for the average life scientist, and the adoption of this powerful technology across different areas has been uneven. In this talk, I will present two rather distinct stories that have the same underlying goal, namely, to suggest a roadmap for proteomics to become truly ubiquitous in all life science research. The first is in computational method development. Proteomics is a prototypical "Big Data" field, but it may be surprising to some that despite the rapid accumulation of LC-MS/MS data in public repositories, for the most part all these data have not been meaningfully reused. This unfortunate situation can be traced to how we are used to analyze data in proteomics in isolation without prior knowledge, and how we store and organize the data. I will discuss our ongoing efforts to change this by organizing proteomics data by spectral similarity, and our vision for a simpler and more user-friendly way to analyze proteomics data. The second is in the application of proteomics to an important problem in microbiology -- the fascinating but annoying ability of bacterial pathogens to survive antibiotic treatment. Antibiotic tolerance, defined as the ability of a bacterial population to outlive lethal doses of antibiotics in a non-proliferating and non-specific way, is distinct from, and less understood, than antibiotic resistance. I will discuss our recent work in applying proteomics and adaptive laboratory evolution to map the "tolerome" (the set of genes and proteins that affect tolerance) in two organisms, Escherichia coli and Staphylococcus aureus, and some hard-learned lessons of how to reduce distraction when dealing with hundreds of differentially expressed proteins. In doing so, I hope to show an example of what proteomics can and cannot do, and how it enables one to make progress towards addressing open-ended biological questions. Bio: Prof. Henry Lam is currently Professor in the Department of Chemical and Biological Engineering in the Hong Kong University of Science and Technology (HKUST). He obtained his Ph. D. (Chemical Engineering) from Massachusetts Institute of Technology in 2005, and received postdoctoral training in the Aebersold group at the Institute for Systems Biology (ISB) in Seattle, Washington. At ISB, he participated in developing data analysis workflows in the then-nascent field of proteomics, some of which have become standard practice today. He has a longstanding interest in making the powerful technology of proteomics more reliable and more accessible to life scientists. Current research in his group focuses on method development in proteomics and metabolomics, particularly in algorithm design and data organization, and applications of proteomics in biological research, particularly in microbiology. ~BME Host: Young Kim~ NOTE:Students registered for the seminar are expected to attend in-person. Zoom link: https://purdue-edu.zoom.us/j/7731446991?pwd=RHdkZTVnRkxTM3J3dnRvY1VLWTlYUT09 -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] Holiday updates
by Gelfand, Johanna K 18 Nov '22

18 Nov '22

Just a few notes as we head full-throttle into the holiday season: Purdue University will be closed next Thursday and Friday (Nov. 24-25). This means all offices, labs and buildings will be closed. This translates to no mail or package delivery, so (hopefully) you haven't ordered anything perishable that will languish until your return on Monday, Nov. 28. We will also be closing and locking the student club room (MJIS 1051) over this time. Any food left in the refrigerator as of 5:00 p.m. on Wednesday, November 23rd will be put in the trash. That being said - users of the Club Room on the 1st floor ARE RESPONSIBLE FOR CLEANING UP YOUR OWN MESSES. Lately, there has been an exponential increase in splattered food not being wiped out of the microwave, and other food debris left on the table surfaces, which has led to an influx of mice (and mice droppings) in this room. If you use the club room, YOU are responsible for cleaning up your mess. We don't want to be forced to shut this area down, but if it continues to be left dirty, with unlabeled food in the refrigerator, we may have to take more drastic measures for everyone's health safety. We will similarly be closing the club room over Winter Break (December 23 - January 3). Researchers also need to make note that for the Winter Recess - The ordering deadline for research materials (animals, chemicals, drugs, etc.) will be noon on Wednesday, December 14, 2022, for delivery dates of December 19 - 22, 2022. There will be no deliveries of any kind on campus from December 22, 2022 through January 3, 2023. This same schedule will be followed for Drug Distribution Center orders. Please plan accordingly. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] News from Purdue Biomedical Engineering - Fall 2022
by Gelfand, Johanna K 18 Nov '22

18 Nov '22

To view this email as a web page, click here.<https://view.deliver.purdue.edu/?qs=cea38bb7bdd5bf94de811487e309d1f7e36ecd6…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/49b22e4e-51…] [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/9ce07102-9c…] [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/a451755f-3b…] Weldon School Friends and Colleagues, It’s one of my greatest privileges each year to write you with updates from the Weldon School of Biomedical Engineering at Purdue. The past year has been a tremendous year for the School with a new undergraduate incoming class of 171 students, over 70 new graduate students, three new faculty, one returning faculty member who brings back rich entrepreneurial leadership experience, and many faculty and staff successes that are in this newsletter. This year also brings new opportunities with our colleagues in Indianapolis in BME at IUPUI and the IU School of Medicine (IUSM) that I expand upon below. We also had an opportunity to work as a faculty and staff team to update our Weldon School of Biomedical Engineering Core Values<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd4dcc0d2d3bd74391f7740a…> that define who we are as a school, how we train and mentor, how we form partnerships and joint ventures, and how we position ourselves for success in research. These are our updated guiding principles that define who we are as a school, how we train and mentor, how we form partnerships and joint ventures, and how we position ourselves for success in research. This community-building process is paying dividends as we take the next giant leaps as the Weldon School of Biomedical Engineering at Purdue. Evolving student training for greater success Our program continues to grow at both the undergraduate and graduate levels. With this growth comes new opportunities to tailor experiences at the undergraduate level in interest areas in bioelectricity, biomechanics, computational biomedicine, and others. Students now have the option for enrichment in particular specialties of biomedical engineering to provide the added depth that potential employers are seeking. At the graduate program level, we have refined a high-contact mentorship process with regular milestones that includes professional development and additional training in grantsmanship and scientific writing. These endeavors lead to new student successes including Ph.D. student Sarah Libring<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd99f15e215b02fdf0a6cd11…> becoming a recipient of the National Cancer Institute F99/K00 Pre-Doctoral to Post-Doctoral Fellowship, and undergraduate student Carl Russell III<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd62e1daf667decbe0546c8f…> being named a Purdue Engineering Fellow. IUPUI Merger – Combining forces for biomedical engineering in Indiana In a joint announcement<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd2ebb8db113bc2ca049def4…> from the Boards of Trustees from both IU and Purdue University, a new direction for the future of Purdue and IU was established for Indianapolis. For the Weldon School, this means that the IUPUI Department of Biomedical Engineering will join forces with us, and we have already started the process! Joey Wallace<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd22259bba85bd84547f6469…>, chair of the department of biomedical engineering at IUPUI is excited for the new opportunities that our unification will bring about and he wanted to share the following message: “From its inception in 1996, the BME program at IUPUI was intimately linked with the Weldon School through a joint PhD program and shared governance. The faculty and staff in Indianapolis look forward to reestablishing and bolstering that relationship to build something truly special for the city and state and I am excited to work with David to make the merging of our two departments as efficient and synergistic as possible." The Purdue and IUPUI Biomedical Engineering programs have a longstanding collaborative relationship at multiple levels. The recent announcement takes this to the next level and by 2024 we will be one BME program with unique capabilities and the best of both worlds – Purdue Engineering in West Lafayette and the engineering in medicine ecosystem with our partners in Indianapolis including the IU School of Medicine and Riley Hospital for Children. New Institute – Increasing collaboration at the intersection of our strengths In the same Trustees’ message, they announced a new joint institute that bridges Purdue Engineering and health-related sciences at Purdue University with the IU School of Medicine and health-related sciences at Indiana University. The institute between universities will build a premier program in engineering, science, and medicine to train the next generation workforce, make new breakthrough discoveries, and develop innovative solutions and life-saving technologies in medicine. This new initiative grew out of the strengths of existing collaborations between the Weldon School of Biomedical Engineering and the IU School of Medicine, and we are kicking things off with a Purdue Engineering/IUSM joint research grant program<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dde2172655917c79a8826b44…>. I have been deeply involved in the Institute planning as the leader of the Purdue team, working closely with our IU colleagues in this new initiative. I will continue to update this community as the exciting new initiative develops. New faculty Over the past year we welcomed three new faculty and one returning faculty from industry to the Weldon School of Biomedical Engineering. Steve Steinhubl, MD<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd1bf58c5351ab9e2b9d5953…>, joins us from Scripps as Reilly Professor of Biomedical Engineering. Steve is a cardiologist and expert in digital medicine and clinical trial design. He was selected as a “Health Equity Faculty Champion <https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd5b4430fb68e51b8d0f2196…> ” to work closely with former U.S. Surgeon General and Purdue Distinguished Professor of Practice Jerome Adams, MD<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd24ad3f33185307b2c31e35…>, to lead a team focused on health equity as it relates to infectious diseases. Taimoor Qazi, PhD<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd6285e6db307d539d856ec5…>, joins us to lead research and teaching in biomaterials and biomechanics. Taimoor is an innovator who couples AI and simulation to guide research in granular biomaterials research with applications in regenerative medicine. Matthew Ward, PhD<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2ddb3bab4da17be810c9b7291…>, is an expert in neuroengineering, device development, and is an alumnus of Purdue BME. Matthew will lead the development of new devices and technologies related to vagal nerve stimulation, gastroparesis, and other areas of neuroengineering. Eugenio Culurciello, PhD<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dda37cf752480279d724a74d…>, returns to BME after a three-year hiatus in industry and brings back a highly successful experience to support further training and entrepreneurial activities in the School. We’ve had an exciting year in the Weldon School. We look forward to the changes ahead as it will help us to realize a greater vision for Biomedical Engineering and Medicine. We are thankful for our eager partners in the IU School of Medicine and IUPUI, and I’m impressed by the unity of vision for the next generation of engineering advances in medicine. Purdue’s strengths lie in its mission and its people, and I will continue to tirelessly evoke the highest standards as Head of BME as we take this next giant leap in Engineering in Medicine. Thank you for your ongoing support, and Boiler Up! [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/dad9306d-7b…] David M. Umulis Dane A. Miller Head and Professor Weldon School of Biomedical Engineering [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/d42bb808-8e…] [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/b8b56304-5d…] [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/9de9fc9b-33…] Chi Hwan Lee addresses glaucoma diagnosis and management through smart soft contact lens The vision of Purdue University biomedical engineer Chi Hwan Lee to develop specialized smart soft contact lenses that can accurately measure intraocular pressure (IOP) in a person's eye could be the latest answer to stopping glaucoma-related blindness. READ MORE<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd2743656564f7ec252afd51…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/c2075421-f2…] BME researchers develop edible QR code to take a shot at fake whiskey A silk tag with a QR code is a security measure that could reveal if whiskey is fake. Developed by biomedical engineers from Purdue University and the National Institute of Agricultural Sciences in South Korea, a smartphone can scan the tag to confirm the drink's authenticity. READ MORE<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2ddde9390f34a989109bb6085…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/20f21762-a8…] Hunting for early biomarkers of Duchenne muscular dystrophy Medical providers currently lack standard imaging biomarkers to forecast cardiomyopathy's early onset or developmental pace. To facilitate those diagnoses, BME's Craig Goergen and IU's Larry W. Markham have developed an innovative method to measure strain in three dimensions. READ MORE<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd9a7b81a3a5809f65ffa901…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/e869cfb8-dc…] [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/e8990c0b-f9…] Purdue team named winner of $1M first place prize in DOT’s Inclusive Design Challenge A team of Purdue engineering professors, led by Bradley Duerstock, professor of practice in biomedical engineering, was named the winner of the $1 million 1st place prize on July 26 in the 2020 U.S. Department of Transportation (DOT) Inclusive Design Challenge (IDC). The contest aimed at improving transportation access to persons with disabilities and individuals with mobility challenges. READ MORE<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd2b6c56608ef9e9e79da67a…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/ebc10e6f-03…] Opioid overdose detection and response startup receives four-year, $2.8M Fast-Track SBIR grant from NIH Rescue Biomedical <https://click.deliver.purdue.edu/?qs=2258260c1e9ae2ddbf7f3ee8f7ba76d14bc3ee…> has received a Fast-Track Small Business Innovation Research, or SBIR, grant from the National Institutes of Health to develop its technology that detects when a person is overdosing on an opioid and delivers naloxone to reverse the action. Hyowon “Hugh” Lee, Rescue Biomedical CEO and associate professor of biomedical engineering at Purdue, said the company looks to partner with recovery clinics and clinicians to identify and work with opioid use disorder (OUD) patients at high risk of overdosing again. READ MORE<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd2df896319d32f29e2af744…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/c3601ace-58…] Claridge receives Schmidt Science Polymaths award Shelley Claridge, associate professor of biomedical engineering and chemistry, is one of 10 recipients of the award, which provides $500,000 a year, paid through their institution, for up to five years to help support part of a research group. READ MORE<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dde67ea327f2528845257ae9…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/c814841d-6b…]<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd63c7b15e011e417f0594fc…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/6a02791e-84…] [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/6667e7b2-3d…] Indiana University, Purdue University announce new vision for Indianapolis campus The MOU to transform IUPUI includes the creation of a joint biosciences engineering institute to harness the power of the universities' collective academic and research strengths and ongoing collaboration between Purdue's Weldon School of Biomedical Engineering and Indiana University's School of Medicine. READ MORE<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dda0cbcbdf0002ad2dc6d123…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/108baaf3-82…] Student success, collaborations highlight Wodicka’s legacy in BME George Wodicka's thinking has been bigger than big, transforming a small research center into the renowned Weldon School of Biomedical Engineering, whose work impacts millions of patients worldwide. READ MORE<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd1a52f0947aea3940dca5a2…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/36e3917c-68…] Umulis, Weldon School featured on College Knowledge podcast David Umulis recently joined Dave Kozak, CEO of College Planning Network and host of the College Knowledge podcast to discuss biomedical engineering at Purdue, Weldon School experiences and programs, and what high school students interested in a career in engineering should be thinking about. READ MORE<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd9442832bfb15ca17a20e42…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/ddb7da18-76…]<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2ddec2600f97f3dbd787e4ff3…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/b81c95aa-92…] [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/c4e33590-83…] Libring, Purdue’s first recipient of National Cancer Institute F99/K00 pre-doctoral to post-doctoral fellowship, closes chapter on impressive Purdue career Sarah Libring first entered the Purdue BME program in August 2017 and has since contributed tremendously through her research, as well as through her involvement with campus organizations. READ MORE<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd1497add24578e7f87d0f40…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/40164393-35…] Graduate research assistant in BME lab chosen as LATinE Trailblazers in Engineering Fellow Current Purdue PhD student, Javier Muñoz Briones, was chosen as a LATinE Trailblazers in Engineering Fellow through Purdue University's College of Engineering for the summer 2022 cohort. The LATinE program has a goal to prepare future trailblazing faculty in engineering with a focus on preparing outstanding scholars who are also committed to increasing the success of Latinx engineers. Trailblazers in Engineering Fellows are selected not only for their outstanding scholarly achievements but also for their potential impact in expanding representation and diversity in engineering. READ MORE<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2ddc45efd66907d0325fb26e7…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/d3a0f15c-c1…] Engineering Fellows program grows; seven graduating seniors to receive $20K including BME's Russell Seven Purdue College of Engineering seniors, including biomedical engineering student Carl Russell III, have been announced as 2022-2023 Purdue Engineering Fellows, becoming the fourth class of recipients since the program’s inception. The program was designed to recognize the accomplishments, contributions, and potential of outstanding seniors. READ MORE<https://click.deliver.purdue.edu/?qs=2258260c1e9ae2dd3051d016ac861c83cc9e69…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/25f2df66-5e…] EMBRIO Institute hosts trainee summer workshop at Purdue This past summer, the inaugural EMBRIO Summer Workshop, themed “Computational Cabal,” was hosted in the Weldon School of Biomedical Engineering. The three-day intensive workshop engaged 44 diverse trainees in achieving new knowledge and skills they are now applying in their research as integral parts of the interdisciplinary whole that will move EMBRIO forward. The workshop brought together BME students with students from biological sciences and engineering domains representing six universities (Purdue University, Indiana University, Morehouse College, University of Notre Dame, University of Pennsylvania, and University of Puerto Rico Mayagüez). READ MORE<https://click.deliver.purdue.edu/?qs=bf51895a70a97f3428b1d4f3ec57bf529ce700…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/515544d3-ae…]<https://click.deliver.purdue.edu/?qs=bf51895a70a97f341185d88496ff4a511108dc…> READ ALL WELDON SCHOOL NEWS FROM 2022<https://click.deliver.purdue.edu/?qs=bf51895a70a97f341bdd94a14b5b72d10902d9…> MAKE A GIFT TO THE WELDON SCHOOL<https://click.deliver.purdue.edu/?qs=bf51895a70a97f34ddf2e63ffebca5dc60f561…> [Facebook]<https://click.deliver.purdue.edu/?qs=bf51895a70a97f34092bdebef819d0a41cf8ba…> [Instagram]<https://click.deliver.purdue.edu/?qs=bf51895a70a97f34dec61d3d77c65ab1552024…> [Twitter]<https://click.deliver.purdue.edu/?qs=bf51895a70a97f349abd246348c8c99e92d74f…> [LinkedIn]<https://click.deliver.purdue.edu/?qs=bf51895a70a97f347cb3c172c145395f3262c1…> [http://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/1/410de3a2-627…] Purdue University Dauch Alumni Center, 403 West Wood Street West Lafayette, IN, 47907, USA Manage Subscriptions<https://click.deliver.purdue.edu/?qs=bf51895a70a97f3420886f68644df379543e7f…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Weldon Graduate Program Announcements November 9th, 2022
by Siemers, Tammy R 17 Nov '22

17 Nov '22

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements November 9th, 2022 * Career and Internship Opportunities * Healthcare Resources for Students<https://bcove.video/3NArCci> * Concord Law Opportunity * 3MT Competition Now Accepting Faculty Nominations * Graduate Professional Development Newsletter (NOV 11) * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Graduate Level Internships, Align Technologies<https://www.linkedin.com/jobs/view/3243820445/?trackingId=Xr8k0nxkBD1KyBf04…> * User Research Doctoral Internship, Slack<https://www.linkedin.com/jobs/view/3343630668/?alternateChannel=search&refI…> * Summer Technical Internship, Evonik<https://www.linkedin.com/jobs/view/3352137959/?alternateChannel=search&refI…> * Validation Engineer Intern, Arthrex<https://www.linkedin.com/jobs/view/3349118561/?alternateChannel=search&refI…> * Internship, Kyverna Therapeutics<https://www.linkedin.com/jobs/view/3320510123/?trackingId=p0%2BbdbBEMRQD2oL…> * Intern, Device Engineering, Gilead<https://gilead.yello.co/jobs/KNd-3DPimB0ZkkQTowdf_w?job_board_id=v42vD4vKxb…> * Drug Development Summer Intern (PhD), Bristol Myers Squibb<https://careers.bms.com/jobs/R1564494?lang=en-us&previousLocale=en-US> * Biologics Development Intern (PhD), Bristol Myers Squibb<https://careers.bms.com/jobs/R1563920?lang=en-us&previousLocale=en-US> Postdoctoral Positions * Post Doc Fellow, Biomedical Engineering, University of Cincinnati<https://jobs.uc.edu/job/Cincinnati-Post-Doc-Fellow%2C-Department-of-Biomedi…> * NPA Website: https://careers.nationalpostdoc.org/jobs/ Full time Positions * Development Senior Engineer, Zimmer Biomet<https://www.linkedin.com/jobs/view/3352997362/?alternateChannel=search&refI…> * Quality Engineer, Bigfoot Biomedical<https://www.linkedin.com/jobs/view/2914907034/?alternateChannel=search&refI…> * Research Assistant, Research Gene Therapy, Nationwide Children's Hospital<https://www.linkedin.com/jobs/view/3349718744/> * Biomechanical Engineer, Rimkus<https://www.simplyhired.com/job/iw5RIyvljDY3C6W3YjVgZq6vJXUJKkmU22Gkho8OSTf…> * R&D Engineer, Medical Murray<https://www.simplyhired.com/job/Fr5jWKLI6vA_VjBajMr4ID2JZims9UwZAsAFbzEBnmH…> * Research Associate, Piper Companies<https://careers.pipercompanies.com/details/85738> * Research Associate, Genomics Base Medicine, Cornell University<https://apps.hr.cornell.edu/recruiting/facultyview.cfm?posting_id=_JOB_POST…> * Sr. Application Researcher, Avantor<https://vwr.wd1.myworkdayjobs.com/en-US/avantorJobs/job/Remote---Japan/Sr-A…> * Research and Development Engineer, Cook Medical<https://jobsearcher.com/j/research-development-engineer-at-cook-medical-in-…> * Associate Clinical Account Specialist, Biosense Webster<https://jobs.jnj.com/en/jobs/2206018844w/associate-clinical-account-special…> * See Attached QR code * Video link: https://bcove.video/3NArCci * Material Science Engineer, Genentech<https://www.simplyhired.com/job/Wnfl8TFIDKQ2-DdKuV0SLVYn0LIEehRH3mYDjXUm4Lb…> (through Visions in View) * Purdue Start-up Job Board<https://purduefoundry.com/jobs?utm_source=Foundry+Mailing+List&utm_campaign…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://careers.actscience.org/>-Association for Clinical and Translational Science * Doc Jobs<https://www.docjobs.com/jobs/list/>-Jobs beyond traditional clinical and academic roles Healthcare Resources for Students See Attached Concord Law Opportunity See attached A partnership has been established that allows WL domestic graduate students to take online courses or microcredentials with Concord Law School through Purdue Global at no or reduced cost. Because Purdue Global/Concord is not connected with SEVIS, international students in the U.S. on residential visas are not eligible to take any classes from them (not even the 1 online class up to 3 credits they are eligible with through Purdue West Lafayette). So, this offering is currently only available for domestic students. See the attached "Flyer" for details, and the other two attachments for course offerings. Interested students should contact Christal Musser in the Office of Interdisciplinary Graduate Programs at PGConcordWL(a)purdue.edu<mailto:PGConcordWL@purdue.edu> to learn more about this opportunity and discuss their specific funding situation and courses of interest. This could be a wonderful opportunity for students wishing to add an understanding of various legal practices they could encounter in their engineering careers. 3MT Competition Now Accepting Faculty Nominations Virtual 3MT(r) 2023 Nomination Form: * Nomination Deadline: January 13, 2023 https://purdue.ca1.qualtrics.com/jfe/form/SV_204r4KOtt2fUIbI What is 3MT(r)? Three Minute Thesis (3MT(r)) is a research communication competition that helps graduate students develop academic, presentation, and research communication skills so that they can effectively explain their research to a non-specialist audience. During each competition, graduate students will have three minutes to present a compelling discussion on their research topic, including its significance and relevance, to the general public. This is a fast-paced competition where the top 10 finalists compete by summarizing their two to three-plus years of research in only three minutes with only one slide. The cash awards for this year's competition have been increased substantially, including $5,000 for first place, $3,000 for second place, and $2,000 for the People's Choice Award winner. The first-place winner will also be invited to compete in the Midwestern Association of Graduate School's (MAGS) annual 3MT(r) competition. 3MT(r) Timeline * Friday, February 10: Draft Video Submission Deadline - Learn more about making a draft video!<https://www.purdue.edu/gradschool/professional-development/documents/Virtua…> * Friday, February 24: Semifinalists Announced * Friday, March 3: Semi-Finals * Monday, March 6: Finalists Announced * Monday, April 10: 3MT(r) Rehearsal * Tuesday, April 11: 3MT(r) Competition Learn more about the Purdue University Graduate School's 3MT(r) competition here: https://www.purdue.edu/gradschool/professional-development/competitions/3mt… Nominees must be current Purdue graduate students studying at the West Lafayette campus. Each nominee will be contacted by Graduate School staff and encouraged to register for the competition. Nominations are not required for students to submit a draft video; they are simply intended to help the Graduate School identify and encouraged talented students to participate. Graduate Professional Development Newsletter (NOV 11) Graduate Professional Development Newsletter (NOV 11)<https://mailimages.purdue.edu/vo/?FileID=31a03dc4-d957-4d95-b442-347ce0f45c…> Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. November 17th Comparing Job Offers (Grad School<https://gspd.gosignmeup.com/public/course/browse>) November 17th Lunch & Learn: Mili Jha November 17th Evaluating and Negotiating a Job Offer (Grad School<https://gspd.gosignmeup.com/public/course/browse>) November 18th PLaCE Workshop: Writing Clearer Paragraphs (PLaCE<https://purdue-place.gosignmeup.com/public/course/browse>) Nov. 18th & 19th 2022 Rising Stars in Engineering in Health Workshop hosted by JHU & Columbia November 21st NAECC and AARCC Friendsgiving November 30th Mentorship Training for Postdocs (Grad School<https://gspd.gosignmeup.com/public/course/browse>) November 30th Preparing to Buy a House (Grad School<https://gspd.gosignmeup.com/public/course/browse>) November 30th Publishing a Scientific Paper (Grad School<https://gspd.gosignmeup.com/public/course/browse>) November 30th Coffee with the Dean (Grad School<https://gspd.gosignmeup.com/public/course/browse>) December 1st The Cover Letter (Grad School<https://gspd.gosignmeup.com/public/course/browse>) December 1st Lunch & Learn: Maria Whipple, M.A. December 1st Talk it Out (Grad School<https://gspd.gosignmeup.com/public/course/browse>) December 1st Equity, Diversity, and Inclusive Teaching in the Community College Setting (CIRTL<https://www.cirtl.net/events/1181>) December 5th Let's Talk Taxes (Grad School<https://gspd.gosignmeup.com/public/course/browse>) December 5th Ethical Dilemmas in Inclusive Teaching: Difficult Dynamics in the Lab (CIRTL<https://www.cirtl.net/events/1223>) Dec. 5th - 8th Comida Para Estudiar (LCC<https://www.purdue.edu/lcc/events/index.php>) Dec. 5th - 9th De-Stress Week of Events (AARCC) December 8th Coffee Chat in MJIS 2041 - Faculty Host: Deva Chan News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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