May 2023 - Bmegradstudents-list

[Bmeroundtable-list] Save the Date: BME Welcome Back Ice Cream Social
by Siemers, Tammy R 10 Jul '23

10 Jul '23

Good Afternoon, We are once again going to host a Welcome Back (for some of you welcome to the Fall semester) Ice Cream Social on the first Friday of classes. Join us for some great conversation and yummy treats as we get the fall semester started. I will send a calendar invite to those that utilize that feature. Date: Friday, August 26th Time: 1-2 pm Location: MJIS South Lawn (rain location: MJIS 2001) I hope you consider joining us! Tammy Tammy Siemers She/Her Associate Director, Graduate Education Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME Roundtable - Tues., May 30
by Gelfand, Johanna K 30 May '23

30 May '23

[cid:image001.jpg@01D99313.B9D18CC0] BME Monday TUESDAY ROUNDTABLE May 30, 2023 Important MJIS Alerts REMINDER: Purdue University is a NON-SMOKING campus. You are not permitted to smoke/vape in or around MJIS. There is a smoking area on the other side of Martin Jischke Drive, near the police station. Remember that the air intakes for the entire building are located externally. If you smoke on the sidewalk outside of MJIS, it is drawn into and distributed throughout the building! Don't do it! Here is a map of all the smoking areas on campus: https://www.purdue.edu/smokefree/Smoking_map.pdf The closest to MJIS is labeled "4" UPCOMING IMPORTANT DATES Week of May 29 Tues., May 30: C.R.A.S.E. (Civilian Response to Active Shooter Events) training is available through the Purdue University Police Department. Contact Sarah Clark (sclark32(a)purdue.edu<mailto:sclark32@purdue.edu>) to sign up for your 9:30, 1:30 or 5:30 session. All faculty and staff are encouraged to attend. For additional information see: https://www.purdue.edu/newsroom/purduetoday/releases/2023/Q2/pupd-to-offer-… Wed., May 31: BME Summer Seminar Series, 9:30 a.m. via Zoom. This week's presenters: Eugene Kim (Tamara Kinzer-Ursem, advisor) will present "The Role of CaMKII, Drebrin-A and F-actin Tripartite in Homeostatic Plasticity" and Rachel Stingel (Riyi Shi, advisor) will present "Excitotoxicity and acrolein damage caused by spinal cord injury - the role of GLT-1." Wed., May 31: Purdue Department of Health & Kinesiology World Class Research Seminar, 3:00 p.m., Lawson B151. Graham Fraser, PhD, will be the guest speaker for the Department of Health & Kinesiology on Wednesday, May 31st, at 3:00 p.m. in Lawson B151. His presentation is entitled "Dynamics of Capillary Blood Flow Regulation in Skeletal Muscle." Thurs., June 1: BME PhD Final Defense Announcement for Jongcheon Lim (H. Lee, advisor). Everyone is invited to attend the public presentation beginning at 3:00 PM in MJIS 2001 and via Zoom. Title: Toward Advanced Neural Interfaces for Selective Vagus Nerve Stimulation Thurs., June 1: BME PhD Preliminary Exam announcement for Claudia Benito Alston (L. Solorio, advisor). Everyone is invited to attend the public presentation beginning at 3:00 PM in DLR 131 and via Zoom. Title: Optimization of a patient-specific 3D printed bone graft for increased osteoinduction through finite element analysis, computational fluid dynamics, as well as in vitro to in vivo modeling Upcoming Opportunity for Fun! Do you play a band instrument? Purdue Bands and Orchestras has just opened registration for the 2023 Purdue University Summer Band! This ensemble is open to all area musicians that are high school age and up. Participation in Purdue's Summer Band is FREE to all. We plan to begin rehearsals on Tuesday, June 20, and rehearse on Tuesday and Thursday afternoons from 4:00-5:30 PM in Hagle Hall, Room 178. Our concert will be held on Thursday, July 20, 6:30 PM at Columbian Park Memorial Island Amphitheater immediately prior to a performance by the Lafayette Citizens' Band. Register Here: https://docs.google.com/forms/d/e/1FAIpQLSd8v47EEuzyl070XPk4QyH0fIBflpdLywl… Upcoming important deadlines and info. Wed., Sept. 6: BMES Early Bird Registration Deadline! Register now to lock in savings with early-bird pricing for the 2023 BMES Annual Meeting (to be held in Seattle, WA, October 11-14). Thousands of biomedical engineers will attend this year's meeting to learn, collaborate, and network. As a BMES member, you can save more than 10% with reduced early bird rates, so if you're not already a member, now would be a good time to join! Click here for details: https://mailchi.mp/e3958bb463f2/o8cvhb9q5x-9335625?e=ea10e317a2 Mon., July 24: Final Grade Entry Begins. (Ends promptly at 5:00 p.m., Tues., August 8th). Committee Updates Academic Programs Update Summer Grading Deadlines: 1. Final Grading windows are found here<https://www.purdue.edu/registrar/faculty/grading/index.html>: * Full 12-week summer session (includes all undergrad and grad-level research students) * Grade entry begins at 8 a.m. Monday July 24th and ends promptly at 5 p.m. Tuesday August 8th. 2. [cid:image002.png@01D99313.B9D18CC0] Guidance on Final grading<https://purdue0.sharepoint.com/:w:/r/sites/RecordsandRegistration/Shared%20…> 3. Now is the perfect time for faculty to take the 15 minutes to get all your required certifications up to date BEFORE the deadline approaches. * FERPA * GLBA * Data Handling * Protecting SSNs 4. This page<https://www.purdue.edu/registrar/faculty/grading/PWL-grade-entry-update.htm…> provides myPurdue grade entry instructions. 5. This page<https://www.purdue.edu/brightspace/Docs/Grades/SubmitFinalGradesToBanner.ph…> provides BrightSpace final grade submission instructions. * Those not making the deadline must use the Grade Change Workflow to submit a grade for each student. * Instructions may be found here<https://www.purdue.edu/registrar/faculty/grading/Grade_Change_Workflow.html…>. Graduate Office Update The Purdue Office of Engagement is sponsoring an "Advancing Graduate Research Impact in Society Professional Development Program for Future Engaged-Scholars." The purpose of the Advancing Graduate Research Impact in Society certification program is to foster the development of engaged scholarship. This professional development program will help increase knowledge, skills, and experience translating your research in ways that help solve societal problems. The program is open is any graduate student or post-doctoral fellow enrolled at Purdue's West Lafayette campus. Participants will meet weekly to learn how to become engaged scholars, develop community partnerships, engage with diverse communities, evaluate engagement activities, and communicate your engaged work. Location: Purdue Grad Student Center, Northwestern Avenue, Room 105 Day & Time: Tuesdays 3:00-4:00 p.m., Fall 2023 Semester. (All sessions are in person) Registration required: Open from May 18 to June 16. If you are interested in learning more or registering, please scan the UR code: [cid:image003.png@01D99313.B9D18CC0] Resources and further information Wed., May 31: BME Summer Seminar Series, 9:30 a.m. via Zoom. This week's presenters: Eugene Kim (Tamara Kinzer-Ursem, advisor) will present "The Role of CaMKII, Drebrin-A and F-actin Tripartite in Homeostatic Plasticity" and Rachel Stingel (Riyi Shi, advisor) will present "Excitotoxicity and acrolein damage caused by spinal cord injury - the role of GLT-1." Eugene Kim (Tamara Kinzer-Ursem, advisor), "The Role of CaMKII, Drebrin-A, and F-actin Tripartite in Homeostatic Plasticity" Abstract: Homeostatic plasticity is defined as the neuron's ability to stabilize its activity to a particular set point, such as the average neuronal firing rate. There is much-emerging evidence that suggests disrupted homeostatic synaptic plasticity leads to neuropsychiatric and neurologic disorders, such as autism spectrum disorder (ASD), Fragile X Syndrome (FXS), and Alzheimer's disease (AD). Out of many ways to regulate homeostatic plasticity, structure-based homeostatic plasticity is one of them. However, structural homeostatic plasticity at the spine head is mainly studied at the post-synaptic density (PSD) and shows wide variance across all studies, such as in-vitro and brain slices. Specifically, spine head enlargement is commonly seen through Ca2+/calmodulin-dependent protein kinase (CaMKII) and filamentous actin (F-actin), but understanding how this translates into structural homeostatic plasticity is lacking. Recent studies have shed light upon the role of Drebrin-A, an actin-binding protein that forms stable F-actin meshes in dendritic spines, and its binding properties with CaMKII and F-actin. However, no studies have shown the interaction of CaMKII, Drebrin-A, and F-actin as a tripartite and how it influences structural homeostatic plasticity. We propose to define the localization of the tripartite in dendritic spine heads and characterize structural homeostatic plasticity due to the tripartite and its interaction with other cytoskeletal proteins using super-resolution microscopy (SRM). Contrary to PSD F-actin dynamics, this tripartite localized at the head-neck interface may serve as a critical indicator in structured-based homeostatic plasticity. Understanding the relationship between tripartite and homeostatic plasticity will open new avenues of pharmacological targets in neuropsychiatric and neurologic disorders. Evaluation link Eugene Kim: https://purdue.ca1.qualtrics.com/jfe/form/SV_6msN1LlhsrNzY9g Rachel Stingel (Riyi Shi, advisor), Excitotoxicity and acrolein damage following (or caused by) spinal cord injury - the role of GLT-1 Abstract: Spinal cord injury (SCI) is a devastating condition that causes variable and often significant sensory, motor, and autonomic dysfunction. Despite extensive research, the limited efficacy of clinical treatments highlights the need for a better understanding of the complex pathology underlying SCI in order to identify new treatment strategies for functional restoration. Immediately following the initial injury (primary injury), secondary inflammatory cascades (secondary injury) perpetuate the extent of damage, and worsen functional outcomes. Acrolein is a reactive α,β-unsaturated aldehyde that forms within hours and remains active for at least two weeks following SCI. It has been found to play an instrumental role in SCI-induced neurodegenerative mechanisms such as oxidative stress, mitochondrial dysfunction, and lipid peroxidation. Excitotoxicity resulting from excess extracellular glutamate accumulation is also heavily implicated in cell death following SCI as well as other neurodegenerative disorders. Synaptic glutamate levels are primarily regulated by glutamate transporter-1 (GLT-1) on astrocyte cell membranes. Evidence showing GLT-1 function is compromised by less reactive aldehydes suggests its potential as a key target for acrolein-mediated dysfunction that could lead to excitotoxicity and neurodegeneration. Thus, we sought to robustly characterize GLT-1 expression following acute SCI and determine if acrolein mediates these findings. Using a clinically relevant T10 contusion model of SCI, we show that: 1) GLT-1 and acrolein levels display an inverse expression pattern as revealed by immunoblotting and immunohistochemical labeling, 2) GLT-1 and acrolein co-localize and co-precipitate following SCI, and 3) the application of exogenous acrolein to intact spinal cord tissue sufficiently reduces GLT-1 expression. Together, these findings have important implications for understanding potential acrolein-mediated excitotoxicity, neuronal regions most at risk, and may reveal targets for therapeutic intervention following acute SCI. Evaluation link Rachel Stingel: https://purdue.ca1.qualtrics.com/jfe/form/SV_0udG1PftA4ygOR8 *Join Zoom Meeting https://purdue-edu.zoom.us/j/98231659969?pwd=T21Oa1B6QzFyQzFvckMzS1doNGlJUT… Meeting ID: 982 3165 9969, Passcode: biomedical Purdue Department of Health & Kinesiology World Class Research Seminar, Wed., May 31, 3:00 p.m., Lawson B151. Graham Fraser, PhD, will be the guest speaker for the Department of Health & Kinesiology on Wednesday, May 31st, at 3:00 p.m. in Lawson B151. His presentation is entitled "Dynamics of Capillary Blood Flow Regulation in Skeletal Muscle." Abstract: Increases in oxidative metabolism, such as during exercise, necessitate increased skeletal muscle blood flow to match oxygen (O2) demand for generating ATP needed for muscular contraction. Skeletal muscle O2 concentration, and other metabolites formed through oxidative and non-oxidative energy pathways serve as direct vasomotor stimulus facilitating oxygen delivery:demand matching. The complex interplay between these metabolically mediated mechanisms, and the potential for overlapping and complementary pathways that produce vasodilation make studying blood flow responses directly in the context of exercising or contracting muscle challenging. In this presentation we quantify the direct capillary level flow responses to acute changes in skeletal muscle oxygen (O2) and carbon dioxide (CO2) concentrations, both in terms of their independent contribution and their combined effects. The dynamics of O2 and CO2 mediated responses and the apparent minimum scale of O2 sensing in microvascular networks will be discussed in the context of potential mechanisms. Bio: Dr. Graham Fraser is an Associate Professor and Coordinator for the Cardiovascular Research group in the Faculty of Medicine at Memorial University of Newfoundland. His NSERC funded research program is focused on the development of novel tools to study blood flow regulation in the microcirculation, and his CIHR research is aimed at examining microvascular regulatory defects in animal models of type 2 diabetes. BME PhD Final Defense Announcement for Jongcheon Lim (H. Lee, advisor). Everyone is invited to attend the public presentation on Thurs., June 1, beginning at 3:00 PM in MJIS 2001 and via Zoom. Title: Toward Advanced Neural Interfaces for Selective Vagus Nerve Stimulation Thesis Committee: Hyowon Lee, Chair; Chi Hwan Lee; Edward Bartlett; Matthew P. Ward Abstract: Vagus nerve branches to multiple organs such as heart, stomach and spleen to regulate their physiological activities. Selective activation of a portion of fibers in the vagus nerve can potentially modulate specific organ activities without off-target effect. Despite recent advancements in microfabrication technology that enables more advanced neural interfaces, current devices for electrical neuromodulation rely on relatively bulky system such as helical cuff electrode for VNS, which stimulates entire fascicle indiscriminately. In this presentation, we show three approaches towards selective vagus nerve stimulation (VNS). First, we investigated VNS using microelectrode with circle and Vicsek fractal shape. Our rat study shows that fractal microelectrode can activate C-fibers in cervical vagus nerve with higher energy efficiency compared to circle microelectrode. Secondly, we developed stretchable and adhesive cuff device for a compliant neural interface for a long-term stability. We designed Y-shaped kirigami thin-film device for stretchable neural interface and applied a tissue-adhesive hydrogel to enable tough adhesion of the cuff electrode, which can be potentially used to fix the position of microelectrode for a reliable selective stimulation with minimal mechanical mismatch. Lastly, we developed a microchannel electrode array device to potentially measure high-quality of single fiber action potential (SFAP) from the abdominal vagal trunk of rat to explore natural patterns selective organ activities which can be used for a fine-tuned selective VNS. Our results show the potential of measuring C-fiber activities evoked by cervical VNS. In the future, we plan to apply an improved design to increase signal to noise ratio to capture the spontaneous SFAP from the teased nerve fibers. Zoom Link: - https://purdue-edu.zoom.us/j/95239025355?pwd=Z2xDOEJ5K3ZKcUdwNXNldTVLNVBNUT… BME PhD Preliminary Exam announcement for Claudia Benito Alston (L. Solorio, advisor). Everyone is invited to attend the public presentation on Thurs., June 1, beginning at 3:00 PM in DLR 131 and via Zoom. Title: Optimization of a patient-specific 3D printed bone graft for increased osteoinduction through finite element analysis, computational fluid dynamics, as well as in vitro to in vivo modeling Thesis Committee: Luis Solorio, Chair; Adrian Buganza Tepole; Deva Chan; Clark T. Barco Abstract: Maxillofacial and oral defects originate from congenital conditions such as cleft palate, diseases such as osteosarcoma that cause malignancies, as well as from injuries due to blasts or vehicular accidents. These defects lead to complications for the patient including difficulty speaking, infections, as well as damaging psychological effects owing to the patient's distorted physical appearance. The current standard of care uses particulates of freeze-dried auto- or allografts covered by a titanium mesh secured in place by screws. This approach is limited by its variability, the length of time the patient is exposed to potential infection during surgery, as well as tight packing often leading to diminished bone regeneration as blood vessels may fail to form. A significant benefit of the current gold standard of freeze-dried particulate is the innate growth factors (GFs) that are released. However, since these are patient-derived the GF composition is poorly defined and varies. To address these fallbacks, a 3D printable, biodegradable, and implantable device with patient-specific shape and a porous core-cover structure was designed. The central hypothesis is that a 3D printed porous cover-core bone graft with spatiotemporally controlled release of GFs FGF-2 and BMP-2 will provide improved vascular infiltration and osteointegration. By using finite element analysis and computational fluid dynamics, we will fine-tune the design to withstand possible masticatory forces as well as optimize inicial plasma influx ensuring complete endogeneous cells permeation, respectively. Overall, through a combination of in silico modeling, in vitro and in vivo studies, we aim to generate a patient-specific bone graft with an increased rate of osteointegration. Zoom Link: https://purdue-edu.zoom.us/j/95213891530 -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] Summer Seminar Announcement: Wed., May 31
by Gelfand, Johanna K 26 May '23

26 May '23

[cid:image001.jpg@01D98F19.E4F0C900] BME Summer Seminar Series Wednesday, May 31st, 2023 9:30-10:30 AM EST Via Zoom Meeting - link below* Evaluation links: Eugene Kim: https://purdue.ca1.qualtrics.com/jfe/form/SV_6msN1LlhsrNzY9g Rachel Stingel: https://purdue.ca1.qualtrics.com/jfe/form/SV_0udG1PftA4ygOR8 Title of Presentation: "The Role of CaMKII, Drebrin-A, and F-actin Tripartite in Homeostatic Plasticity" Eugene Kim (Tamara Kinzer-Ursem, advisor) [cid:image007.jpg@01D98F1A.36B60340] Abstract: Homeostatic plasticity is defined as the neuron's ability to stabilize its activity to a particular set point, such as the average neuronal firing rate. There is much-emerging evidence that suggests disrupted homeostatic synaptic plasticity leads to neuropsychiatric and neurologic disorders, such as autism spectrum disorder (ASD), Fragile X Syndrome (FXS), and Alzheimer's disease (AD). Out of many ways to regulate homeostatic plasticity, structure-based homeostatic plasticity is one of them. However, structural homeostatic plasticity at the spine head is mainly studied at the post-synaptic density (PSD) and shows wide variance across all studies, such as in-vitro and brain slices. Specifically, spine head enlargement is commonly seen through Ca2+/calmodulin-dependent protein kinase (CaMKII) and filamentous actin (F-actin), but understanding how this translates into structural homeostatic plasticity is lacking. Recent studies have shed light upon the role of Drebrin-A, an actin-binding protein that forms stable F-actin meshes in dendritic spines, and its binding properties with CaMKII and F-actin. However, no studies have shown the interaction of CaMKII, Drebrin-A, and F-actin as a tripartite and how it influences structural homeostatic plasticity. We propose to define the localization of the tripartite in dendritic spine heads and characterize structural homeostatic plasticity due to the tripartite and its interaction with other cytoskeletal proteins using super-resolution microscopy (SRM). Contrary to PSD F-actin dynamics, this tripartite localized at the head-neck interface may serve as a critical indicator in structured-based homeostatic plasticity. Understanding the relationship between tripartite and homeostatic plasticity will open new avenues of pharmacological targets in neuropsychiatric and neurologic disorders. Excitotoxicity and acrolein damage following (or caused by) spinal cord injury - the role of GLT-1 Rachel Stingel (Riyi Shi, advisor) [cid:image008.png@01D98F1A.36B60340] Abstract: Spinal cord injury (SCI) is a devastating condition that causes variable and often significant sensory, motor, and autonomic dysfunction. Despite extensive research, the limited efficacy of clinical treatments highlights the need for a better understanding of the complex pathology underlying SCI in order to identify new treatment strategies for functional restoration. Immediately following the initial injury (primary injury), secondary inflammatory cascades (secondary injury) perpetuate the extent of damage, and worsen functional outcomes. Acrolein is a reactive α,β-unsaturated aldehyde that forms within hours and remains active for at least two weeks following SCI. It has been found to play an instrumental role in SCI-induced neurodegenerative mechanisms such as oxidative stress, mitochondrial dysfunction, and lipid peroxidation. Excitotoxicity resulting from excess extracellular glutamate accumulation is also heavily implicated in cell death following SCI as well as other neurodegenerative disorders. Synaptic glutamate levels are primarily regulated by glutamate transporter-1 (GLT-1) on astrocyte cell membranes. Evidence showing GLT-1 function is compromised by less reactive aldehydes suggests its potential as a key target for acrolein-mediated dysfunction that could lead to excitotoxicity and neurodegeneration. Thus, we sought to robustly characterize GLT-1 expression following acute SCI and determine if acrolein mediates these findings. Using a clinically relevant T10 contusion model of SCI, we show that: 1) GLT-1 and acrolein levels display an inverse expression pattern as revealed by immunoblotting and immunohistochemical labeling, 2) GLT-1 and acrolein co-localize and co-precipitate following SCI, and 3) the application of exogenous acrolein to intact spinal cord tissue sufficiently reduces GLT-1 expression. Together, these findings have important implications for understanding potential acrolein-mediated excitotoxicity, neuronal regions most at risk, and may reveal targets for therapeutic intervention following acute SCI. *Join Zoom Meeting https://purdue-edu.zoom.us/j/98231659969?pwd=T21Oa1B6QzFyQzFvckMzS1doNGlJUT… Meeting ID: 982 3165 9969 Passcode: biomedical Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] News from Purdue Biomedical Engineering - Spring 2023
by Gelfand, Johanna K 26 May '23

26 May '23

To view this email as a web page, click here.<https://view.deliver.purdue.edu/?qs=99eca313fe3228ee89084d4e0b44d55cd3f14c0…> [https://image.deliver.purdue.edu/lib/fe3111717064047c761279/m/5/49b22e4e-51…] [A picture containing text, font, screenshot, logo Description automatically generated] [A black text on a white background Description automatically generated with medium confidence] Alumni, colleagues, and friends of the Weldon School of Biomedical Engineering, Welcome to our spring newsletter! In this letter I want to highlight the outstanding achievements of our students and welcome a new class of graduates. Our School continues to rise in the rankings and our College of Engineering achieved another outstanding year with an overall #4 ranking<https://click.deliver.purdue.edu/?qs=433950d926fa3e33af7990b7733906a988b2e4…> according to US News & World Report. This spring, several faculty members led students internationally for service learning, and study abroad experiences in Rwanda and South Korea <https://click.deliver.purdue.edu/?qs=433950d926fa3e33be544a7a3b447284283bbb…> and several trips are underway in May to Japan and Scandinavia. Each trip is centered around a critical aspect of Biomedical Engineering - whether the focus is regulatory affairs, agent-based modeling, or point-of-care diagnostics, these immersive experiences have lasting impact. Also, this spring, it was great to add to our alumni numbers! Ninety-two undergraduate students received their BS degree in BME, and 41 graduate students completed their MS and PhD degrees. This upcoming fall we welcome 140 new sophomore students, continuing our nearly 20% year-over-year growth in students choosing BME! Our faculty have excelled in research, teaching, and entrepreneurship this year. BME faculty-led companies have received substantial recognition and funding this year including Dr. Kinzer-Ursem and Dr. Linnes' company OmniVis<https://click.deliver.purdue.edu/?qs=433950d926fa3e33cb001a5832507de310536d…>, and Dr. Harbin's GeniPhys<https://click.deliver.purdue.edu/?qs=433950d926fa3e33b10f232ec6234a6842ccd8…>. Faculty member Dr. Duerstock was elected to the AIMBE College of Fellows<https://click.deliver.purdue.edu/?qs=433950d926fa3e33f03589d074662ebba00748…> and Dr. Vlachos was elected as a Fellow of the American Heart Association<https://click.deliver.purdue.edu/?qs=433950d926fa3e333f7f039e3fe41f7a5b956a…>. We continue to build momentum in BME and the next few years will see tremendous new opportunities emerge in Indianapolis and West Lafayette for current and future Boilermakers. Thanks again for all your support! Boiler Up! [A close-up of a signature Description automatically generated with low confidence] David M. Umulis Acting Dane A. Miller Head and Professor, Weldon School of Biomedical Engineering Senior Vice Provost for Purdue University in Indianapolis [A picture containing font, graphics, text, screenshot Description automatically generated] [A few women in lab coats looking at a piece of paper Description automatically generated with low confidence] Affordable cervical cancer test holds life-preserving promise Purdue researchers Jacqueline Linnes and Sulma Mohammed are determined to save lives by developing a low-cost, point-of-care paper test that could revolutionize cervical cancer detection worldwide. READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e33b4eb6df8bf844e38824d24…> [Close-up of a person's eye Description automatically generated with medium confidence] New high-tech startup developing smart contact lenses for glaucoma diagnosis and management Optometrists, ophthalmologists and their patients will benefit from new, high-tech tools to detect glaucoma at its earliest stages thanks to a startup that will commercialize smart contact lenses developed at Purdue University. READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e33559faf10c8e7cd3a516faa…> [A picture containing vehicle, transport, land vehicle, mode of transport Description automatically generated] How could future autonomous transportation be accessible to everyone? Brad Duerstock, a professor of practice in industrial engineering and biomedical engineering at Purdue University, is working on accessible accommodations for autonomous vehicles while the technology is still in its early days. The goal is that when these vehicles start to hit the road everywhere, they will be able to accommodate anyone who wants to use them. READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e336df5a2a4d800b7078e61ce…> [A black background with white text Description automatically generated with low confidence] [A picture containing box, plastic, packing materials, transparency Description automatically generated] OmniVis recognized with prestigious Most Fundable Companies designation OmniVis, a Purdue University-affiliated biotechnology company focused on the speed, accuracy and economics of pathogen detection, has been named to the fifth annual Most Fundable Companies list from Pepperdine University's Graziadio Business School. READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e33a1f78e280bc206ebf772bd…> [A person taking a picture of her eye Description automatically generated with medium confidence] Purdue-connected digital health startup wins phase 1 of NIH competition for maternal health HemaChrome, a digital health startup that uses smartphone technology to noninvasively and instantly measure blood hemoglobin levels, has won phase 1 of the National Institutes of Health's RADx Tech for Maternal Health Challenge. READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e331d6942cd3aafbd59cf6848…> [A person wearing green gloves and white coat holding a round object Description automatically generated with low confidence] Life sciences company secures $6M in Series A funding Life sciences company GeniPhys has completed a $6 million Series A round of funding, the company announced Wednesday. GeniPhys has developed a material known as Collymer, a highly-purified form of collagen that is used to support tissue generation. READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e33fd171c3ddef4046489fc9b…> [A picture containing font, graphics, screenshot, text Description automatically generated] [A group of people posing for a photo Description automatically generated with medium confidence] Karaoke and wearable health devices: Weldon School students hit a high note exploring the future of wearable sensors in new course The potential impact of wearable sensors in the medical field is significant, which is what led two professors from Purdue's Weldon School of Biomedical Engineering to launch a new course in spring 2023 titled "BME 595: Wearable Sensors in Healthcare." READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e333cc7d69a58443b91272af6…> [A person and person in lab coats Description automatically generated with low confidence] Purdue engineering graduate program ranked in the top 2% nationally, 4th among more than 200 universities in the US The 2023-24 U.S. News & World Report national graduate school rankings, released Tuesday (April 25), put Purdue's College of Engineering at No. 4 out of 220 for the third consecutive year, with the nation's top four as MIT; Stanford; the University of California, Berkeley and Purdue. READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e33910ac50a1b7447e5cd6a8e…> [A picture containing text, font, screenshot, graphic design Description automatically generated] Changing lives through inventions: Purdue jumps to the top 5 of global leaders in US patents received In 2022, Purdue Research Foundation received an impressive 192 patents from the U.S. Patent and Trademark Office (USPTO), placing it fifth internationally. The top-five breakthrough comes on the heels of Purdue's No. 6 ranking in both 2020 and 2021, when it received 175 and 169 patents, respectively. READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e33be9c4549ff8901a2487438…> [A person holding a transparent device Description automatically generated with low confidence] Purdue, IU research teams awarded pilot funding through Engineering in Medicine collaboration Research teams led by faculty at both Indiana University School of Medicine and the Purdue University College of Engineering were recently awarded pilot grants to fund joint research projects as part of a growing ecosystem of collaboration and integration between the two schools and to continue to build momentum for the planned institute for Engineering in Medicine. READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e337abbf7a2ef958158c8ac2c…> [A person standing in front of a blue wall Description automatically generated with low confidence] Office Hours: A Conversation with BME/IE's Martinez Ramses Martinez never bothers turning on a TV when he checks into a hotel. The room's safe is a much more entertaining option. Martinez loves puzzles, and he considers lock-picking one of the ultimate tests. The professor who holds a joint appointment in industrial engineering and biomedical engineering gave Purdue chemical engineering student Yasar Dambo the lowdown on his hobbies, including different kind of "enhancements" (hacking) Martinez does in his spare time, and much more in the latest "Office Hours." READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e33743721448036feaab5a0b6…> [A picture containing font, screenshot, graphics, graphic design Description automatically generated] [A group of people posing for a photo Description automatically generated] Weldon School students, faculty complete study abroad trips to Rwanda, South Korea Panama City Beach. South Padre Island. Daytona Beach. College students flock to these popular spring break destinations to relax and recharge. But for 15 students from Purdue's Weldon School of Biomedical Engineering, spring break was an opportunity to study abroad to experience new cultures, make new connections, and grow their skills in the field of biomedical engineering. READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e339b123bcb7cd0cda72e9a74…> [A picture containing text, logo, screenshot, font Description automatically generated] Purdue BME student selected for NSF Graduate Research Fellowship Mikayla Roach, PhD student from Purdue University's Weldon School of Biomedical Engineering has been selected for the National Science Foundation's 2023 Graduate Research Fellowship Program (NSF GRFP). The program recognizes and supports outstanding graduate students in NSF-supported science, technology, engineering, and mathematics disciplines who are pursuing research-based master's and doctoral degrees at accredited United States institutions. READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e3342d94b001a2fee74bc4ce6…> [A picture containing human face, clothing, smile, glasses Description automatically generated] Frazier selected for DoD National Defense Science and Engineering Graduate Fellowship Purdue Weldon School PhD student Lizzy Frazier was recently selected to receive the U.S. Department of Defense (DoD) National Defense Science and Engineering Graduate (NDSEG) Fellowship. The NDSEG Fellowship is designed to increase the number of U.S. citizens or nationals trained in disciplines of science and engineering of military importance. READ MORE<https://click.deliver.purdue.edu/?qs=433950d926fa3e3322660176025b5ad8f21499…> READ ALL WELDON SCHOOL NEWS FROM 2023<https://click.deliver.purdue.edu/?qs=433950d926fa3e3386b75bb50eba6417a5cd4d…> MAKE A GIFT TO THE WELDON SCHOOL<https://click.deliver.purdue.edu/?qs=433950d926fa3e332579547f32ee755215bc5e…> [Facebook]<https://click.deliver.purdue.edu/?qs=433950d926fa3e3340a421151b66211fc684b9…> [Instagram]<https://click.deliver.purdue.edu/?qs=433950d926fa3e337352d88f757f2c1d61f134…> [Twitter]<https://click.deliver.purdue.edu/?qs=433950d926fa3e33d7d693bd41574df75e843f…> [LinkedIn]<https://click.deliver.purdue.edu/?qs=433950d926fa3e3313c828dbf8cf5aa1535e28…> [A picture containing logo, symbol, design Description automatically generated] Purdue University Dauch Alumni Center, 403 West Wood Street West Lafayette, IN, 47907, USA -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] "Club Room" - 1st floor MJIS
by Gelfand, Johanna K 25 May '23

25 May '23

This is a reminder that we are still on "probation" with Purdue Health and Safety as to whether or not we will be able to keep this room open and available to our students. The past two days, there has been a sharp uptick of problems with the room being left in a mess - leftovers sitting out, sticky spills on the floor, spills on the table, etc., etc. Our service workers have been cleaning it up, but it is NOT their responsibility! Please remind everyone you work with that each individual is responsible for cleaning up after themselves. Should there be an unannounced inspection, and the "powers that be" would see the mess, they would shut the room down immediately, and we would lose access to the refrigerators, microwaves, etc. permanently. There are a large number of "new" people in the building (e.g., SURF, incoming grad students, etc.) who are not on our mailing list yet. Please make sure everyone in your labs is aware of the room use policy. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Weldon Graduate Program Announcements May 24th, 2023
by Siemers, Tammy R 24 May '23

24 May '23

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements May 24th, 2023 * Career and Internship Opportunities * 2023 Summer Career and Professional Development Opportunities at NIH * Congratulations, Christopher Schorr! * Graduate Professional Development Newsletter (May 19) * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Quality Engineering Co-op Fall 2023, Mammotome<https://jobs.danaher.com/global/en/job/DANAGLOBALR1241203EXTERNALENGLOBAL/Q…> Postdoctoral Positions * Research Fellow, Physiology and Biomedical Engineering, Mayo Clinic<https://jobs.mayoclinic.org/job/-/-/33647/49060480656> * NPA Website: https://careers.nationalpostdoc.org/jobs/ Full Time Positions * R&D Engineer, Enlight Medical Technologies<https://www.simplyhired.com/job/eKyWVxKnfUizI_bFK5whUWK2gXa7NAY_xiUCTxGqFmy…> * Biomedical Engineer, BCVS Group<https://www.simplyhired.com/job/o57hLQu-BF-Rgw3L9WTTUMWDEZJWYEAO1sbuHN6bToF…> (Contract Work) * Engineer, Imaging and Data Solutions, Novo Nordisk<https://careers.novonordisk.com/job/Lexington-Engineer-Imaging-Data-and-Sol…> * Mechanical Engineer, RTI, Smith & Nephew<https://smithnephew.wd5.myworkdayjobs.com/en-US/External/job/Pittsburgh-PA/…> * Product/Process Engineer, Draper<https://careers-draper.icims.com/jobs/7384/product-process-engineer/job?mod…> * Clinical Engineer, Goldbelt<https://careers-goldbelt.icims.com/jobs/11428/job?utm_source=indeed_integra…> * Purdue Start-up Job Board<https://purduefoundry.com/jobs?utm_source=Foundry+Mailing+List&utm_campaign…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://careers.actscience.org/>-Association for Clinical and Translational Science * Academic Careers<https://academiccareers.com/> * Doc Jobs<https://www.docjobs.com/jobs/list/>-Jobs beyond traditional clinical and academic roles 2023 Summer Career and Professional Development Opportunities at NIH Join us for the 2023 summer career and professional development opportunities at NIH! [VIRTUAL] NIH SUMMER ENRICHMENT CURRICULUM 2023 The 2023 NIH Virtual Summer Enrichment Curriculum<https://www.training.nih.gov/nih_virtual_summer_enrichment_program> is starting the week of June 5th. All events/activities are free. To help you sharpen your science skills and develop both professionally and personally, we have developed a summer-long series of activities. This summer's online curriculum will focus on the exciting science we do at the NIH and on career/professional development, and wellness topics for students at all educational levels. We encourage you to look at all the program offerings and identify events that will help you achieve your scientific and career goals. * Curriculum for Students in College, Graduate, and Professional School<https://www.training.nih.gov/nih_virtual_summer_enrichment_program#college> * Curriculum for High School Students and Recent Graduates<https://www.training.nih.gov/nih_virtual_summer_enrichment_program#high%20s…> Summer Intensive Series - Sexual & Gender Minority Health<https://dpcpsi.nih.gov/sgmro/summer-intensive-series>: New this year, the NIH Sexual & Gender Minority Research Office (SGMRO) sponsors a summer intensive series to enhance scientists' knowledge of sexual and gender minority (SGM) health research. Open to all trainees, including those outside of NIH, the series explores SGM health research, its intersection with science, policy, communication, and community engagement. Weekly sessions feature renowned SGM health researchers, panel discussions, breakout groups, and journal club discussions. Participants can attend one or multiple sessions, with a certificate of completion awarded for attending at least 5 out of 7 sessions. Visit the SGM Health Research SIS webpage<https://dpcpsi.nih.gov/sgmro/summer-intensive-program> to learn more. Register Here for the Summer Intensive Series - Sexual & Gender Minority Health<https://forms.office.com/pages/responsepage.aspx?id=Bg240C0fnECcrczad-tzgV3…>. BECOMING A RESILIENT SCIENTIS SERIES IS BACK (Summer & Fall 2023) The NIH OITE offers a series of workshops<https://www.training.nih.gov/nih_becoming_a_resilient_scientist_series> to help you develop your confidence and resilience in various challenging situations. The series includes four (Summer) or five (Fall) webinars, each followed by a small-group discussion. These sessions focus on strategies for academic success, thriving in research and healthcare careers, building resilience, overcoming obstacles, and mentoring. Attending the entire series is recommended as concepts and themes will be developed progressively, allowing you to integrate and refine the information. Previous participants reported increased resilience, improved stress management, and highly recommended the series. For more information and schedule, please visit here<https://www.training.nih.gov/nih_becoming_a_resilient_scientist_series>: Summer 1, 2023 - College and Graduate/Professional School Students<https://www.training.nih.gov/nih_becoming_a_resilient_scientist_series#summ…> Summer 2, 2023 - Students in High School and Recent High School Graduates<https://www.training.nih.gov/nih_becoming_a_resilient_scientist_series#summ…> Fall 2023 - Postbacs, Graduate/Professional School Students, Postdocs<https://www.training.nih.gov/nih_becoming_a_resilient_scientist_series#fall…> [HYBRID] NIH Graduate & professional School fair 2023 Student registration is now open for the NIH Graduate & Professional School Fair<https://www.training.nih.gov/gp_fair> on July 19, 2023! The fair offers hybrid workshops on getting to graduate and/or professional school, in-person exhibitor sessions to learn about participating institutions and programs on July 19, 2023, and virtual exhibitor sessions on Whova from July 25 to August 11, 2023. Over 270 institutions have registered to participate, providing valuable resources for advanced education and networking opportunities. Stay tuned for the lists of participating institutions and workshop speakers, coming soon. NIH Career Symposium The 16th Annual NIH Career Symposium concluded last week after three exciting days of networking and career exploration. This virtual event provided a unique opportunity for trainees to hear directly from professionals across a wide array of careers to learn about their individual career stories and experiences. With over 6000 attendees from NIH and around the world and with 275 speakers & panelists, this was our largest Career Symposium to date. Recordings of the main talks from the symposium are now available to everyone on the OITE YouTube channel: https://www.youtube.com/playlist?list=PLxnpU66KqCcj-FHpFDMkC3qRHVExBRjnu While all events are free of charge, advance registration is required. To register for events and read event descriptions, please visit Upcoming Events<https://www.training.nih.gov/events/upcoming> on the OITE website and locate the events that interest you or check the virtual summer enrichment curriculum calendar<https://www.training.nih.gov/nih_virtual_summer_enrichment_program_curricul…>. Please subscribe<https://www.training.nih.gov/sas/_20/426/> to our mailing list, NIH-OITE-INFO, if you would like to receive summer updates and information on training programs at the NIH in the future. We hope these opportunities will broaden your knowledge, inspire your curiosity in the field of biomedical research, and prepare you for success. Embrace this opportunity to engage with the NIH community and discover new possibilities in your own journey. Congratulations to Christopher Schorr Who Has Some Great Things to Celebrate! He just recently published 2 papers and was awarded the Distinguished Community Engagement Award. * Schorr et. al https://www.mdpi.com/1422-0067/24/9/8349#<https://www.mdpi.com/1422-0067/24/9/8349> * Schorr et al. https://journals.lww.com/co-hematology/Fulltext/9900/Deficits_in_our_unders… Graduate Professional Development Newsletter (May 19) Graduate Professional Development Newsletter (May 19)<https://mailimages.purdue.edu/vo/?FileID=178c836d-1093-4b33-87b9-a709bc9d09…> Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. May 24th NSF Fellowship Workshop - Research Statement (Register Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4090>) May 24th USDA AFRI Fellowship Info Session (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4089>) May 24th Preparing to Buy a House (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4137>) May 24th GRIP workshop: Citation Management with Zotero (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4133>) May 24th-25th Facilitating Entering Mentoring Workshop (CIMER<https://sites.google.com/wisc.edu/facilitatingenteringmentoring/home?pli=1>) May 25th Eating Right When Your Budget is Tight (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4143>) May 25th NSF Fellowship Help Session (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4097>) May 26th Credit Cards and Credit Scores (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4139>) May 29th Deadline to RSVP for Food Trucks & Families Event @ Purdue Memorial Mall (RSVP<https://purdue.ca1.qualtrics.com/jfe/form/SV_1S14irSJKuaT14y>) May 31st How to Find and Prepare for Fellowship Applications (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4102>) May 31st NSF Fellowship Help Session (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4099>) June 5th Publishing a Scientific Paper (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4091>) June 6th CARE-ing Support: Responding to Disclosures of Interpersonal Violence (CARE<https://gspd.gosignmeup.com/public/Course/browse?courseid=4100>) June 6th NDSEG (Defense Research) Fellowship Info Session (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4125>) June 6th Budgeting and Saving Money (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4141>) June 12th Food Trucks & Families Event @ Purdue Memorial Mall (RSVP<https://purdue.ca1.qualtrics.com/jfe/form/SV_1S14irSJKuaT14y>) June 14th RCR: Discipline-Specific Training (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4130>) June 14th NSF Fellowships - Getting Started (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4103>) June 14th GRIP workshop: Citation Management with Zotero (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4134>) June 15th Business Meal Etiquette (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4129>) June 15th Postdoc Grant Writing: Logic Flow and Methods (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4106>) June 15th NSF Fellowship Help Session (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4105>) June 19th Debt Management (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4136>) June 20th Fellowship Office Hour for Grad Students and Postdocs (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4107>) June 21st NSF Fellowships - Personal Statement (Grantsmanship) (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4104>) June 22nd Mentorship Training for Postdocs: Communication Between Mentors & Mentees (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4110>) June 22nd NSF Fellowship Help Session (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4108>) June 27th Preparing to Buy a House (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4138>) June 28th NSF Fellowship Workshop - Research Statement (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4111>) June 28th Credit Cards and Credit Scores (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4140>) June 29th NSF Fellowship Help Session (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4109>) July 6th NSF Fellowship Help Session (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4116>) July 7th Power & Control Workshop (CARE<https://gspd.gosignmeup.com/public/Course/browse?courseid=4101>) July 7th Postdoc Orientation (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4112>) July 14th RCR: Discipline-Specific Training (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4131>) July 18th Publishing a Scientific Paper (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4092>) July 18th NSF Fellowship Life Sciences Panel (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4113>) July 18th NSF Fellowship Physical and Computational Sciences Panel (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4118>) July 18th Fellowship Office Hour for Grad Students and Postdocs (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4117>) July 19th NSF Fellowship Engineering Panel (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4119>) July 19th NSF Fellowship Social Sciences and Education Panel (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4114>) July 19th NIH Graduate & Professional School Fair (Register Here<https://www.training.nih.gov/gp_fair>) July 20th NSF Fellowship Agriculture Panel (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4115>) July 20th Business Meal Etiquette (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4145>) July 20th NSF Fellowship Help Session (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4120>) July 24th Budgeting and Saving Money (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4142>) July 25th Computational Fellowships Info Session (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4126>) July 26th How to Find and Prepare for Fellowship Applications (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4121>) July 26th NDSEG (Defense Research) Fellowship Info Session (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4124>) July 27th Postdoc Grant Writing: All About NSF (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4123>) July 27th NSF Fellowship Help Session (Enroll Here<https://gspd.gosignmeup.com/public/Course/browse?courseid=4122>) July 24th-25th Facilitating Entering Mentoring Workshop (CIMER<https://sites.google.com/wisc.edu/facilitatingenteringmentoring/home?pli=1>) News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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[Bmeroundtable-list] BME Summer Seminar Announcement: May 24th 9:30-10:30am EST via Zoom
by Rowen, Elizabeth Pearl 23 May '23

23 May '23

We encourage all of you to attend and support our grad students as they participate in the second milestone of their PhD. Feedback on their presentation style and content is critical to their professional development and will be of great benefit to our students. We hope to see you there! [cid:image001.jpg@01D9898B.7AAAE5A0] BME Summer Seminar Series Wednesday, May 24th, 2023 9:30-10:30 AM EST Via Zoom Meeting - link below* Evaluation link: Fahmida Sultana Laboni: https://purdue.ca1.qualtrics.com/jfe/form/SV_d5KOVoQQX0rz1sy Cell Shape Changes Driven by Actomyosin Contractility Fahmida Sultana Laboni (Taeyoon Kim, advisor) [A person in a red dress Description automatically generated with low confidence] Abstract: Living cells undergo continuous shape changes facilitated by contractile forces. The actin cytoskeleton plays a crucial role in generating the necessary contractile forces for various cellular processes. To investigate the effects of actomyosin contractility on cellular-scale changes, numerous in vitro experiments have been conducted using synthetic cell-like systems. These systems typically comprise actin, cross-linking proteins, and myosin motors enclosed within lipid vesicles or water droplets. These experiments aim to understand how forces derived from actomyosin contractility contribute to alterations in cell structure and function. Despite the insights these artificial systems have offered, inherent experimental constraints have kept us from completely comprehending the underlying mechanisms governing the changes in cell structure. In order to surpass the constraints and systematically study alterations in cell morphology, we created an agent-based model. This model represents a simple cell-like structure that consists of a discrete actomyosin cortex, osmotic pressure, and cell membrane. The purpose of this model is to better understand how these components interact and contribute to changes in cell shape. The actomyosin cortex consists of actin filaments, cross-linking proteins, and molecular motors. It is assumed that a fraction of the cross-linking proteins can be bound to the membrane. Motions of all elements are governed by the Langevin equation based on Brownian dynamics. Using the model, we explored a wide parametric space consisting of network connectivity, motor density, and cortex-membrane coupling. We found that forces generated from the actomyosin network induce distinct cell shape changes depending on conditions. If the cortex is tightly coupled to the membrane, contractile forces lead to uneven membrane surfaces. If the cortex is weakly coupled to the membrane, the cortex is separated from the membrane and contracts by itself. Interestingly, blebs are formed when the cortex induces enough contractility, and the cortex-membrane coupling is at an intermediate level. Results from our study shed light on fundamental mechanisms of cell shape changes driven by a competition between osmotic pressure and actomyosin contractility. *Join Zoom Meeting https://purdue-edu.zoom.us/j/98811885943?pwd=Nll1MlE3TTYyOHZJL3hIYlpGSXhUUT… Meeting ID: 988 1188 5943 Passcode: biomedical Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME Monday Roundtable - May 22, 2023
by Gelfand, Johanna K 22 May '23

22 May '23

[cid:image005.jpg@01D98C8F.FBA66BA0] BME Monday ROUNDTABLE May 22, 2023 DEPUTY HEAD'S NOTE This past week was truly the beginning of the summer break. Enjoy it! * The BME Summer Seminar Series kicked off last Wednesday. It was a good one. Dear faculty, please come. It is good to help celebrate the preliminary accomplishment of our students (especially in the early years of their PhD) in their PhD research, important to provide your critiques to their research and presentation. To fellow graduate students, it is also good to learn from your peers and cheer for them. https://purdue-edu.zoom.us/j/98231659969?pwd=T21Oa1B6QzFyQzFvckMzS1doNGlJUT…. * The deadline for the TBE workshop is this coming Thursday. Please give a serious consideration. Trailblazers in Engineering (TBE) is a multi-day workshop focused on preparing future outstanding engineering scholars for future engineering faculty careers who are also committed to increase the success of underrepresented communities of engineers. Important MJIS Alerts Week of May 22: Exterior washing of windows in MJIS will take place this week. If you feel like you're being watched, look out your windows to see if there is someone there. We don't know specifically what days they will be working on MJIS, but it will be this week. There will be lifts moving around the building, so please be aware and be careful. REMINDER: Purdue University is a NON-SMOKING campus. You are not permitted to smoke/vape in or around MJIS. There is a smoking area on the other side of Martin Jischke Drive, near the police station. Remember that the air intakes for the entire building are located externally. If you smoke on the sidewalk outside of MJIS, it is drawn into and distributed throughout the building! Don't do it! Here is a map of all the smoking areas on campus: https://www.purdue.edu/smokefree/Smoking_map.pdf The closest to MJIS is labeled "4" Also, this is the time of year when there are numerous unknown people moving throughout the building. This is also the optimal time for undesirable people to take advantage of the increased unknown traffic. In order to protect your personal belongings, lock your door if there is no one in your office area. We have had teams of criminals working campus buildings in the past, stealing wallets, purses, etc. by simply trying doors and entering unlocked areas. Also, do not admit anyone into a secure area (e.g., the lab block) if you do not know them. Keep personal items tucked away and out of sight. Do not be the victim of a "crime of convenience!" UPCOMING IMPORTANT DATES Week of May 22 Mon., May 22: Center for Diabetes and Metabolic Diseases Research Seminar, 12:00 noon via Zoom. Rita Saroufim, Pediatric Endocrinology Fellow - PGY6, Pediatric Endocrinology & Diabetology, Riley Hospital for Children at Indiana University Health, will present "Fellow Research Presentation." Zoom link: https://iu.zoom.us/s/87501979533 This seminar series is sponsored by the Indiana University School of Medicine. Tues., May 23: BME PhD Defense Announcement for Mrugesh Krishna Parasa (Dr. Kevin Solomon, advisor). Everyone is invited to attend the public presentation beginning at 3:00 PM via Zoom. Title of the Thesis Research: Programmable Control of Protein Activity via Formation of Biomolecular Condensates in Bacteria. Wed., May 24: BME Summer Seminar Series, 9:30 a.m., via Zoom. The BME Summer Seminar Series will run from May 17th - August 9th. This week, Fahmida Sultana Laboni (Taeyoon Kim advisor) will present "Cell Shape Changes Driven by Actomyosin Contractility" as part of the BME Summer Seminar Series on Wednesday, May 24 at 9:30 a.m. via Zoom. Thurs., May 25: Application Deadline for Trailblazers in Engineering workshop, to be held on the Purdue campus July 25-26. Trailblazers in Engineering (TBE) is a multi-day workshop focused on preparing future outstanding engineering scholars for future engineering faculty careers who are also committed to increase the success of underrepresented communities of engineers. Trailblazers in Engineering Fellows are selected not only for their outstanding scholarly achievements but also for their potential impact in expanding representation and diversity in engineering. See attached flyer for application instructions. Upcoming Opportunity for Fun! Do you play a band instrument? Purdue Bands and Orchestras has just opened registration for the 2023 Purdue University Summer Band! This ensemble is open to all area musicians that are high school age and up. Participation in Purdue's Summer Band is FREE to all. We plan to begin rehearsals on Tuesday, June 20, and rehearse on Tuesday and Thursday afternoons from 4:00-5:30 PM in Hagle Hall, Room 178. Our concert will be held on Thursday, July 20, 6:30 PM at Columbian Park Memorial Island Amphitheater immediately prior to a performance by the Lafayette Citizens' Band. Register Here: https://docs.google.com/forms/d/e/1FAIpQLSd8v47EEuzyl070XPk4QyH0fIBflpdLywl… Upcoming important deadlines and info. Tues., May 30: C.R.A.S.E. (Civilian Response to Active Shooter Events) training is available through the Purdue University Police Department. Contact Sarah Clark (sclark32(a)purdue.edu<mailto:sclark32@purdue.edu>) to sign up for your 9:30, 1:30 or 5:30 session. All faculty and staff are encouraged to attend. For additional information see: https://www.purdue.edu/newsroom/purduetoday/releases/2023/Q2/pupd-to-offer-… Wed., May 31: Purdue Department of Health & Kinesiology World Class Research Seminar, 3:00 p.m., Lawson B151. Graham Fraser, PhD, will be the guest speaker for the Department of Health & Kinesiology on Wednesday, May 31st, at 3:00 p.m. in Lawson B151. His presentation is entitled "Dynamics of Capillary Blood Flow Regulation in Skeletal Muscle." Thurs., June 1: BME PhD Final Defense Announcement for Jongcheon Lim (H. Lee, advisor). Everyone is invited to attend the public presentation beginning at 3:00 PM in MJIS 2001 and via Zoom. Title: Toward Advanced Neural Interfaces for Selective Vagus Nerve Stimulation Thurs., June 1: BME PhD Preliminary Exam announcement for Claudia Benito Alston (L. Solorio, advisor). Everyone is invited to attend the public presentation beginning at 3:00 PM in DLR 131 and via Zoom. Title: Optimization of a patient-specific 3D printed bone graft for increased osteoinduction through finite element analysis, computational fluid dynamics, as well as in vitro to in vivo modeling Wed., Sept. 6: BMES Early Bird Registration Deadline! Register now to lock in savings with early-bird pricing for the 2023 BMES Annual Meeting (to be held in Seattle, WA, October 11-14). Thousands of biomedical engineers will attend this year's meeting to learn, collaborate, and network. As a BMES member, you can save more than 10% with reduced early bird rates, so if you're not already a member, now would be a good time to join! Click here for details: https://mailchi.mp/e3958bb463f2/o8cvhb9q5x-9335625?e=ea10e317a2 Committee Updates Graduate Office Update The Purdue Office of Engagement is sponsoring an "Advancing Graduate Research Impact in Society Professional Development Program for Future Engaged-Scholars." The purpose of the Advancing Graduate Research Impact in Society certification program is to foster the development of engaged scholarship. This professional development program will help increase knowledge, skills, and experience translating your research in ways that help solve societal problems. The program is open is any graduate student or post-doctoral fellow enrolled at Purdue's West Lafayette campus. Participants will meet weekly to learn how to become engaged scholars, develop community partnerships, engage with diverse communities, evaluate engagement activities, and communicate your engaged work. Location: Purdue Grad Student Center, Northwestern Avenue, Room 105 Day & Time: Tuesdays 3:00-4:00 p.m., Fall 2023 Semester. (All sessions are in person) Registration required: Open from May 18 to June 16. If you are interested in learning more or registering, please scan the UR code: [cid:image006.png@01D98C8F.FBA66BA0] Resources and further information BME PhD Defense Announcement for Mrugesh Krishna Parasa (Dr. Kevin Solomon, advisor). Everyone is invited to attend the public presentation on Tues., May 23, beginning at 3:00 PM via Zoom. Title of the Thesis Research: Programmable Control of Protein Activity via Formation of Biomolecular Condensates in Bacteria. Thesis Committee members: Dr. Kevin Solomon, Dr. Tamara Kinzer-Ursem, Dr. David Thompson, Dr. Leopold Green Abstract: Biomolecular condensates or membraneless organelles are phase separated proteins and/or other biomolecules that are ubiquitous in eukaryotic cells. While these condensates may be liquid with exchange and diffusion of their components with the rest of the cell (e.g. cytoplasm), they locally concentrate their constituent biomolecules altering their interactions in normal cellular processes. Here, we exploit this phenomenon via reversible coacervate formation to control the activity of cellular proteins in E. coli. To induce liquid-liquid phase separation, we fuse proteins to elastin-like polypeptides (ELP) that reversibly aggregate in response to increases in temperature and/or changes in intracellular pH. In so doing, we sequester their fusion partners from the cytoplasm, limiting their ability to participate in cytoplasmic reactions. We have demonstrated this concept in vivo with enzymes and transcription factors for switchable control of protein activity with temperature. For example, I-SceI mediated cleavage of a host genome can be inhibited by increasing the cultivation temperature, creating a simple temperature-sensitive kill switch; accidental release will lower the culture temperature leading to cell death. Similarly, coupled transcription factors exhibit a 2-fold increase in transcription in response to temperature. More importantly, the threshold for coacervate formation and control of protein activity may be tuned through appropriate design of the ELP fusion partner. Our results introduce a simple yet effective, rapid and tunable approach to control protein activity via induction of coacervate formation that may form a powerful new tool for synthetic biology. Zoom link: https://purdue-edu.zoom.us/j/99880181010 BME Summer Seminar Series, Wed., May 24, 9:30 a.m., via Zoom. Fahmida Sultana Laboni (Taeyoon Kim advisor) will present "Cell Shape Changes Driven by Actomyosin Contractility". Abstract: Living cells undergo continuous shape changes facilitated by contractile forces. The actin cytoskeleton plays a crucial role in generating the necessary contractile forces for various cellular processes. To investigate the effects of actomyosin contractility on cellular-scale changes, numerous in vitro experiments have been conducted using synthetic cell-like systems. These systems typically comprise actin, cross-linking proteins, and myosin motors enclosed within lipid vesicles or water droplets. These experiments aim to understand how forces derived from actomyosin contractility contribute to alterations in cell structure and function. Despite the insights these artificial systems have offered, inherent experimental constraints have kept us from completely comprehending the underlying mechanisms governing the changes in cell structure. In order to surpass the constraints and systematically study alterations in cell morphology, we created an agent-based model. This model represents a simple cell-like structure that consists of a discrete actomyosin cortex, osmotic pressure, and cell membrane. The purpose of this model is to better understand how these components interact and contribute to changes in cell shape. The actomyosin cortex consists of actin filaments, cross-linking proteins, and molecular motors. It is assumed that a fraction of the cross-linking proteins can be bound to the membrane. Motions of all elements are governed by the Langevin equation based on Brownian dynamics. Using the model, we explored a wide parametric space consisting of network connectivity, motor density, and cortex-membrane coupling. We found that forces generated from the actomyosin network induce distinct cell shape changes depending on conditions. If the cortex is tightly coupled to the membrane, contractile forces lead to uneven membrane surfaces. If the cortex is weakly coupled to the membrane, the cortex is separated from the membrane and contracts by itself. Interestingly, blebs are formed when the cortex induces enough contractility, and the cortex-membrane coupling is at an intermediate level. Results from our study shed light on fundamental mechanisms of cell shape changes driven by a competition between osmotic pressure and actomyosin contractility. *Join Zoom Meeting: https://purdue-edu.zoom.us/j/98811885943?pwd=Nll1MlE3TTYyOHZJL3hIYlpGSXhUUT… Meeting ID: 988 1188 5943 Passcode: biomedical Evaluation link: for Fahmida Sultana Laboni: https://purdue.ca1.qualtrics.com/jfe/form/SV_d5KOVoQQX0rz1sy Purdue Department of Health & Kinesiology World Class Research Seminar, Wed., May 30, 3:00 p.m., Lawson B151. Graham Fraser, PhD, will be the guest speaker for the Department of Health & Kinesiology on Wednesday, May 31st, at 3:00 p.m. in Lawson B151. His presentation is entitled "Dynamics of Capillary Blood Flow Regulation in Skeletal Muscle." Abstract: Increases in oxidative metabolism, such as during exercise, necessitate increased skeletal muscle blood flow to match oxygen (O2) demand for generating ATP needed for muscular contraction. Skeletal muscle O2 concentration, and other metabolites formed through oxidative and non-oxidative energy pathways serve as direct vasomotor stimulus facilitating oxygen delivery:demand matching. The complex interplay between these metabolically mediated mechanisms, and the potential for overlapping and complementary pathways that produce vasodilation make studying blood flow responses directly in the context of exercising or contracting muscle challenging. In this presentation we quantify the direct capillary level flow responses to acute changes in skeletal muscle oxygen (O2) and carbon dioxide (CO2) concentrations, both in terms of their independent contribution and their combined effects. The dynamics of O2 and CO2 mediated responses and the apparent minimum scale of O2 sensing in microvascular networks will be discussed in the context of potential mechanisms. Bio: Dr. Graham Fraser is an Associate Professor and Coordinator for the Cardiovascular Research group in the Faculty of Medicine at Memorial University of Newfoundland. His NSERC funded research program is focused on the development of novel tools to study blood flow regulation in the microcirculation, and his CIHR research is aimed at examining microvascular regulatory defects in animal models of type 2 diabetes. BME PhD Final Defense Announcement for Jongcheon Lim (H. Lee, advisor). Everyone is invited to attend the public presentation on Thurs., June 1, beginning at 3:00 PM in MJIS 2001 and via Zoom. Title: Toward Advanced Neural Interfaces for Selective Vagus Nerve Stimulation Thesis Committee: Hyowon Lee, Chair; Chi Hwan Lee; Edward Bartlett; Matthew P. Ward Abstract: Vagus nerve branches to multiple organs such as heart, stomach and spleen to regulate their physiological activities. Selective activation of a portion of fibers in the vagus nerve can potentially modulate specific organ activities without off-target effect. Despite recent advancements in microfabrication technology that enables more advanced neural interfaces, current devices for electrical neuromodulation rely on relatively bulky system such as helical cuff electrode for VNS, which stimulates entire fascicle indiscriminately. In this presentation, we show three approaches towards selective vagus nerve stimulation (VNS). First, we investigated VNS using microelectrode with circle and Vicsek fractal shape. Our rat study shows that fractal microelectrode can activate C-fibers in cervical vagus nerve with higher energy efficiency compared to circle microelectrode. Secondly, we developed stretchable and adhesive cuff device for a compliant neural interface for a long-term stability. We designed Y-shaped kirigami thin-film device for stretchable neural interface and applied a tissue-adhesive hydrogel to enable tough adhesion of the cuff electrode, which can be potentially used to fix the position of microelectrode for a reliable selective stimulation with minimal mechanical mismatch. Lastly, we developed a microchannel electrode array device to potentially measure high-quality of single fiber action potential (SFAP) from the abdominal vagal trunk of rat to explore natural patterns selective organ activities which can be used for a fine-tuned selective VNS. Our results show the potential of measuring C-fiber activities evoked by cervical VNS. In the future, we plan to apply an improved design to increase signal to noise ratio to capture the spontaneous SFAP from the teased nerve fibers. Zoom Link: - https://purdue-edu.zoom.us/j/95239025355?pwd=Z2xDOEJ5K3ZKcUdwNXNldTVLNVBNUT… BME PhD Preliminary Exam announcement for Claudia Benito Alston (L. Solorio, advisor). Everyone is invited to attend the public presentation on Thurs., June 1, beginning at 3:00 PM in DLR 131 and via Zoom. Title: Optimization of a patient-specific 3D printed bone graft for increased osteoinduction through finite element analysis, computational fluid dynamics, as well as in vitro to in vivo modeling Thesis Committee: Luis Solorio, Chair; Adrian Buganza Tepole; Deva Chan; Clark T. Barco Abstract: Maxillofacial and oral defects originate from congenital conditions such as cleft palate, diseases such as osteosarcoma that cause malignancies, as well as from injuries due to blasts or vehicular accidents. These defects lead to complications for the patient including difficulty speaking, infections, as well as damaging psychological effects owing to the patient's distorted physical appearance. The current standard of care uses particulates of freeze-dried auto- or allografts covered by a titanium mesh secured in place by screws. This approach is limited by its variability, the length of time the patient is exposed to potential infection during surgery, as well as tight packing often leading to diminished bone regeneration as blood vessels may fail to form. A significant benefit of the current gold standard of freeze-dried particulate is the innate growth factors (GFs) that are released. However, since these are patient-derived the GF composition is poorly defined and varies. To address these fallbacks, a 3D printable, biodegradable, and implantable device with patient-specific shape and a porous core-cover structure was designed. The central hypothesis is that a 3D printed porous cover-core bone graft with spatiotemporally controlled release of GFs FGF-2 and BMP-2 will provide improved vascular infiltration and osteointegration. By using finite element analysis and computational fluid dynamics, we will fine-tune the design to withstand possible masticatory forces as well as optimize inicial plasma influx ensuring complete endogeneous cells permeation, respectively. Overall, through a combination of in silico modeling, in vitro and in vivo studies, we aim to generate a patient-specific bone graft with an increased rate of osteointegration. Zoom Link: https://purdue-edu.zoom.us/j/95213891530 -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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BME PhD Final Defense Announcement for Jongcheon Lim (H. Lee, advisor)
by May, Sandra M 20 May '23

20 May '23

BME PhD Final Defense Announcement for Jongcheon Lim (H. Lee, advisor) Everyone is invited to attend the public presentation beginning at 3:00 PM. Title: Toward Advanced Neural Interfaces for Selective Vagus Nerve Stimulation Date: June 1, 2023 Time: 3:00 PM Location: MJIS 2001 and Zoom - https://purdue-edu.zoom.us/j/95239025355?pwd=Z2xDOEJ5K3ZKcUdwNXNldTVLNVBNUT… Thesis Committee: Hyowon Lee, Chair; Chi Hwan Lee; Edward Bartlett; Matthew P. Ward Abstract: Vagus nerve branches to multiple organs such as heart, stomach and spleen to regulate their physiological activities. Selective activation of a portion of fibers in the vagus nerve can potentially modulate specific organ activities without off-target effect. Despite recent advancements in microfabrication technology that enables more advanced neural interfaces, current devices for electrical neuromodulation rely on relatively bulky system such as helical cuff electrode for VNS, which stimulates entire fascicle indiscriminately. In this presentation, we show three approaches towards selective vagus nerve stimulation (VNS). First, we investigated VNS using microelectrode with circle and Vicsek fractal shape. Our rat study shows that fractal microelectrode can activate C-fibers in cervical vagus nerve with higher energy efficiency compared to circle microelectrode. Secondly, we developed stretchable and adhesive cuff device for a compliant neural interface for a long-term stability. We designed Y-shaped kirigami thin-film device for stretchable neural interface and applied a tissue-adhesive hydrogel to enable tough adhesion of the cuff electrode, which can be potentially used to fix the position of microelectrode for a reliable selective stimulation with minimal mechanical mismatch. Lastly, we developed a microchannel electrode array device to potentially measure high-quality of single fiber action potential (SFAP) from the abdominal vagal trunk of rat to explore natural patterns selective organ activities which can be used for a fine-tuned selective VNS. Our results show the potential of measuring C-fiber activities evoked by cervical VNS. In the future, we plan to apply an improved design to increase signal to noise ratio to capture the spontaneous SFAP from the teased nerve fibers.

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BME PhD Preliminary Exam announcement for Claudia Benito Alston (L. Solorio, advisor)
by May, Sandra M 20 May '23

20 May '23

BME PhD Preliminary Exam announcement for Claudia Benito Alston (L. Solorio, advisor) Everyone is invited to attend the public presentation beginning at 3:00 PM. Title: Optimization of a patient-specific 3D printed bone graft for increased osteoinduction through finite element analysis, computational fluid dynamics, as well as in vitro to in vivo modeling Date: June 1st, 2023 Time: 3:00 PM Location: DLR 131 and Zoom - https://purdue-edu.zoom.us/j/95213891530 Thesis Committee: Luis Solorio, Chair; Adrian Buganza Tepole; Deva Chan; Clark T. Barco Abstract: Maxillofacial and oral defects originate from congenital conditions such as cleft palate, diseases such as osteosarcoma that cause malignancies, as well as from injuries due to blasts or vehicular accidents. These defects lead to complications for the patient including difficulty speaking, infections, as well as damaging psychological effects owing to the patient’s distorted physical appearance. The current standard of care uses particulates of freeze-dried auto- or allografts covered by a titanium mesh secured in place by screws. This approach is limited by its variability, the length of time the patient is exposed to potential infection during surgery, as well as tight packing often leading to diminished bone regeneration as blood vessels may fail to form. A significant benefit of the current gold standard of freeze-dried particulate is the innate growth factors (GFs) that are released. However, since these are patient-derived the GF composition is poorly defined and varies. To address these fallbacks, a 3D printable, biodegradable, and implantable device with patient-specific shape and a porous core-cover structure was designed. The central hypothesis is that a 3D printed porous cover-core bone graft with spatiotemporally controlled release of GFs FGF-2 and BMP-2 will provide improved vascular infiltration and osteointegration. By using finite element analysis and computational fluid dynamics, we will fine-tune the design to withstand possible masticatory forces as well as optimize inicial plasma influx ensuring complete endogeneous cells permeation, respectively. Overall, through a combination of in silico modeling, in vitro and in vivo studies, we aim to generate a patient-specific bone graft with an increased rate of osteointegration.

1 0