May 2023 - Bmegradstudents-list

FW: ⭐ NEW! Specialty Abstract Window Now Open
by Gelfand, Johanna K 10 May '23

10 May '23

From: BMES <communications(a)bmes.org<mailto:communications@bmes.org>> Sent: Wednesday, May 10, 2023 12:00 PM Subject: ⭐ NEW! Specialty Abstract Window Now Open ---- External Email: Use caution with attachments, links, or sharing data ---- 3 new tracks to submit an abstracts for BMES 2023 View this email in your browser<https://mailchi.mp/46500abb230c/o8cvhb9q5x-9333753?e=ea10e317a2> [https://mcusercontent.com/c253dd2a969c1c996423387a0/images/46c47d16-7ea5-2b…] NEW in 2023: Specialty Tracks Abstract Submission BMES is excited to announce a new abstract submission window for the 2023 Specialty Tracks! As we seek to push the frontiers of biomedical innovation and showcase the research of our industry's foremost researchers like you, we've launched a new category of abstract submissions to enhance this year's conference theme: Science, Technology, and Social Change. This is great news if you are looking to increase your chances of securing an oral presentation at this year’s BMES Annual Meeting to be held in Seattle, WA, from October 11-14. From now until June 7 at 3:00 P.M. ET, we are welcoming submissions for the three specialty tracks<https://bmes.us5.list-manage.com/track/click?u=c253dd2a969c1c996423387a0&id…>. Don't miss this opportunity to showcase your research and insights at the 2023 BMES annual meeting. Specialty Tracks: Immunoengineering Data Analysis and Deep Learning Strategies Social Transformation To get started, read the detailed submission information<https://bmes.us5.list-manage.com/track/click?u=c253dd2a969c1c996423387a0&id…> section on our website. We look forward to highlighting your research findings in Seattle! Specialty Track Abstract Submission DEADLINE: Wednesday, June 7 at 3:00 p.m. ET Start You Abstract Submission<https://bmes.us5.list-manage.com/track/click?u=c253dd2a969c1c996423387a0&id…> Please note that the extended deadline applies ONLY to the specialty tracks. To submit an abstract for one of the 18 tracks being offered, Late-breaking and Undergraduate abstracts will open next month and be eligible for a poster presentation only. To view a full list of tracks, Click Here<https://bmes.us5.list-manage.com/track/click?u=c253dd2a969c1c996423387a0&id…>. For questions regarding the abstract submission process, please contact Abstracts(a)bmes.org<mailto:abstracts@bmes.org>. [Facebook]<https://bmes.us5.list-manage.com/track/click?u=c253dd2a969c1c996423387a0&id…> [Twitter]<https://bmes.us5.list-manage.com/track/click?u=c253dd2a969c1c996423387a0&id…> [LinkedIn]<https://bmes.us5.list-manage.com/track/click?u=c253dd2a969c1c996423387a0&id…> [Link]<https://bmes.us5.list-manage.com/track/click?u=c253dd2a969c1c996423387a0&id…> [Website]<https://bmes.us5.list-manage.com/track/click?u=c253dd2a969c1c996423387a0&id…> This email was sent to smmay(a)purdue.edu<mailto:smmay@purdue.edu> why did I get this?<https://bmes.us5.list-manage.com/about?u=c253dd2a969c1c996423387a0&id=c9183…> unsubscribe from this list<https://bmes.us5.list-manage.com/unsubscribe?u=c253dd2a969c1c996423387a0&id…> update subscription preferences<https://bmes.us5.list-manage.com/profile?u=c253dd2a969c1c996423387a0&id=c91…> Biomedical Engineering Society · 8201 Corporate Drive · Suite 1125 · Landover, MD 20785 · USA

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BME PhD Defense Announcement for Xiao Liu (E. Pienaar, advisor)
by May, Sandra M 09 May '23

09 May '23

BME PhD Defense Announcement for Xiao Liu (E. Pienaar, advisor) Everyone is invited to attend the public presentation beginning at 1:00 PM. Title of the Thesis Research: A DEEP UNDERSTANDING OF EBOLA VIRUS VLP ASSEMBLY: ODE-BASED MODELING APPROACH Date: May 15, 2023 Time: 1:00 PM Place: MJIS 2001 Thesis Committee members: Elsje Pienaar, Nan Kong, Leopold Green, Robert Stahelin Abstract: EBOV infection remains to be a challenge to human health by its high mortality rate. There are only two antibody-based therapy approved today, and the mortality rate is still high. This can be partially due to the fact that study on EBOV is strictly limited to BSL-4 labs, which hinders our understanding of the pathogen. We also lack a systematical and quantitative view of EBOV infection. Mathematical modeling has been used to assist biological and medical studies for a long time, as it has the advantage of integrating data and providing quantitative insight to a biosystem. In our study, we build the primary ODE-based model of EBOV at subcellular level step by step. Through our computation al study, we propose that PS can directly influence the oligomerization process of VP40 filaments and the budding process of VLPs. Also, the oligomerization of VP40 filaments may also follow the nucleation-elongation process. We conduct in-silico simulation to evaluate the efficiency of fendiline in treating EBOV. We find that while in general, fendiline can decrease VLP production, there can be fendiline-induced VLP production at certain time points due to slow filament growth rate or fast VLP budding rate. Also, fendiline is relatively more effective when applied in the budding stage. Moreover, it can be extra efficient when applied with VLP budding step targeted treatment. Finally, we integrate nucleoprotein (NP) into our model. We predict that NP increase VLP production through impacting filament oligomerization and VLP budding steps. Also, dual-effect of NP on VLP production may exist, as too high NP/VP40 production ratio can inversely decrease VLP production. From the aspect of protein expression time, we find that a bit earlier NP production than VP40 production is beneficial for both IB-containing VLPs production and prevention in energy waste on empty VLPs. Overall, we have built a solid foundation towards mathematical EBOV model and demonstrated its ability in assisting experimental EBOV studies.

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[Bmeroundtable-list] BME Monday Roundtable - May 8, 2023
by Gelfand, Johanna K 08 May '23

08 May '23

[cid:image009.jpg@01D98188.2EE5D590] BME MONDAY ROUNDTABLE May 8, 2023 DEPUTY HEAD'S NOTE Dear all, I hope your semester has ended well. For some of the faculty/staff, there may be one more day of work to turn in the grades by Tuesday (5/9) at 5 pm. So good luck! For those of you who have started traveling, have fun and enjoy the summer. We have had some good weather in the past weekend. * Recently, a video shoot was completed that will showcase the new undergraduate depth areas, design labs, and six student spotlights. They will soon be added to the "new and improved" BME undergraduate website to be completed later this summer. Please check it out when it is completed. Comments are welcome. * A group of BME undergraduate students have left for Japan on a study abroad trip led by Yunjie Tong and Aaron Lottes. A few such trips will take place during the summer. We love to see our BME students visit every corner of the world, representing our university and the Weldon School. * I am excited about the Spring 2023 commencement. For our Weldon undergraduate students, it will be in Division II on Friday (5/12) at 2:30 p.m., Edward C. Elliott Hall of Music. They will be marching through the campus along with students from a few other engineering departments. For our PhD graduates, the hooding ceremony will be on Sunday (5/14) at 7 pm, Edward C. Elliott Hall of Music. I am so proud of these students. Congratulations to faculty who have been their faculty mentors. Job well done. Big accomplishments. * Please go on to take a look at these wonderful pictures taken in the BMEGSA and BMES joint end-semester celebration. Congratulations to all the award winners. Celebrating Our Students! Last Friday, BMEGSA and BMES hosted a celebration for all of our BME students. Here are just some of the photos from that day: [cid:image010.jpg@01D98188.2EE5D590][cid:image011.jpg@01D98188.2EE5D590] [cid:image012.jpg@01D98188.2EE5D590] Important MJIS Alert Starting Tuesday, May 16th (NOTE new date!), Martin Jischke Drive will be CLOSED to all traffic. The university will be performing infrastructure repairs in the area. The street will be closed to traffic for most, if not all of the summer. When the street reopens, bike lanes will replace the on-street parking, although we do not currently have details/confirmation on the entire process yet. Stay tuned for additional details. UPCOMING IMPORTANT DATES Week of May 8 Mon., May 8: BME PhD Preliminary Exam Announcement for Brendan K. Ball (D. Brubaker, advisor), 11:00 a.m., MJIS 2001 and via Zoom. Title: Alzheimer's Disease Pathology Driven by Orexin and Type 2 Diabetes. Wed., May 10: Diabetes Research Virtual Seminar Series, 2:00 p.m., via Zoom. Katalin Susztak, MD, PhD, Professor of Medicine & Genetics, Director of Penn/CHOP Kidney Innovation Center, University of Pennsylvania, will present "Shifting Focus in Diabetes Care: Moving from Glucose Control to Complications Prevention." Wed., May 10: BME PhD Defense Announcement for James K. Nolan (H. Lee, advisor), 1:30 p.m., DLR 131. Title: Multi-Analyte Biosensing with Enzymatic Electrochemical Sensors. Wed., May 10: BME PhD Preliminary Exam Announcement for Michael Zimmerman (A. Chubykin and K. Jayant, co-advisors). Everyone is invited to attend the public presentation beginning at 2:00 pm in LILY G456 and via Zoom. Title: Understanding Learning and Memory: The Role of Neural Oscillations. Thurs., May 11: BRAG Session, 11:30 a.m., MJIS 2001. We cordially invite you to our upcoming BRAG session featuring Dr. Nan Kong, Professor and Deputy Head, Weldon School of Biomedical Engineering and Associate Director for Health Systems and Marta E. Gross Fellow, Regenstrief Center for Healthcare Engineering, Purdue University. During this session, Professor Kong will be sharing newly gained insights from his position as a Deputy Department Head with a talk titled, "What should you really "BRAG" about in faculty job search and offer negotiation". Mark your calendars for Thursday, May 11, from 11:30 am to 12:30 pm, and join us in MJIS 2001 for a productive lunch session. If you have any dietary restrictions, please let us know in advance. Please RSVP to the Outlook invitation sent following this email or directly to us (Kaisa Ejendal, Monisha Elumalai and Linlin Li. We welcome all attendees and encourage you to bring a Postdoc/Visiting scholar/Research engineer friend along with you!!!! Fri., May 12, Spring Commencement, Engineering Undergraduate Students, 2:30 p.m., Edward C. Elliott Hall of Music. Fri., May 12: Diabetes Data and Hypothesis Hub (D2H2) Seminar, 12:00 p.m., via Zoom. Dr. Avi Ma'ayan will present "The Diabetes Data and Hypothesis Hub (D2H2) and the Playbook Partnership Workflow Builder (PPWB): Bioinformatics Tools for Hypothesis Generation via Data Integration." Register here: https://scgcorp.zoom.us/webinar/register/WN_YgWw6WDTRX6TfaugZ3OBXg Fri., May 12-Sat., May 13: Inaugural Krannert Cardiovascular Research Center Biennial, sponsored by the Indiana University School of Medicine at the JW Marriott and Eiteljorg Museum, Indianapolis, IN. Krannert is conducting a nationally recognized CME event May 12-13 (Fri-Sat) on Myocardial Infarction & Reperfusion Injury. We cordially invite you to join us if possible. We have a strong line up of speakers on the topic who are renowned for their decades of contributions to the field. We are hoping for an event that would capture almost 50 years of activity in the field of ischemia/reperfusion and place it in a context to chart the course forward with the goal of improving care for heart attack patients. This is a great opportunity to meet thought leaders, engage in transformative science, and hopefully be part of a journey to advance CV research. For Program Agenda & Registration, please follow the link: https://medicine.iu.edu/institutes/cardiovascular/research/biennial Sun., May 14: Spring Commencement, Master's and Doctor of Philosophy Students (all colleges/schools), 7:00 p.m., Edward C. Elliott Hall of Music. Upcoming Opportunity for Fun! Do you play a band instrument? Purdue Bands and Orchestras has just opened registration for the 2023 Purdue University Summer Band! This ensemble is open to all area musicians that are high school age and up. Participation in Purdue's Summer Band is FREE to all. We plan to begin rehearsals on Tuesday, June 20, and rehearse on Tuesday and Thursday afternoons from 4:00-5:30 PM in Hagle Hall, Room 178. Our concert will be held on Thursday, July 20, 6:30 PM at Columbian Park Memorial Island Amphitheater immediately prior to a performance by the Lafayette Citizens' Band. Register Here: https://docs.google.com/forms/d/e/1FAIpQLSd8v47EEuzyl070XPk4QyH0fIBflpdLywl… Upcoming important deadlines and info. Wed., May 17: BME Summer Seminar Series, 9:30 a.m., via Zoom. The BME Summer Seminar Series will run from May 17th - August 9th. The first week's speakers will be Ruhi Sharmin and Brendan Ball. Full schedule is attached. Fri., May 19: BME PhD Preliminary Exam Announcement for Shulan Xiao (K. Jayant, advisor), Everyone is invited to attend the presentation beginning at 11:00 a.m. in MJIS 2001 and via Zoom. Title: The Biophysical Basis of Sensory Feature Binding in Cortical Pyramidal Neurons. Thurs., May 25: Application Deadline for Trailblazers in Engineering workshop, to be held on the Purdue campus July 25-26. Trailblazers in Engineering (TBE) is a multi-day workshop focused on preparing future outstanding engineering scholars for future engineering faculty careers who are also committed to increase the success of underrepresented communities of engineers. Trailblazers in Engineering Fellows are selected not only for their outstanding scholarly achievements but also for their potential impact in expanding representation and diversity in engineering. See attached flyer for application instructions. Committee Updates Academic Programs Update Fall 2023 Course Schedule is attached to this email. Drop-in virtual help sessions can assist faculty with end-of-semester Brightspace, other instructional technology - Purdue University Online - Purdue University<https://discover.online.purdue.edu/news/2023/04/05%20-%20Drop-in%20virtual%…> Full Term (16 Weeks) and Second Eight-Week Session grade entry (meeting between March 6 and May 6) begins at 8 a.m. April 21 and ends promptly at 5 p.m. May 9. 1. Now is the perfect time for faculty to take the 15 minutes to get all their required certifications up to date BEFORE the deadline approaches. * FERPA * GLBA * Data Handling * Protecting SSNs 2. This page<https://www.purdue.edu/registrar/faculty/grading/PWL-grade-entry-update.html> provides myPurdue grade entry instructions. 3. This page<https://www.purdue.edu/brightspace/Docs/Grades/SubmitFinalGradesToBanner.php> provides BrightSpace final grade submission instructions. 4. Those not making the deadline can use the Grade Change Workflow. * Instructions may be found here<https://www.purdue.edu/registrar/faculty/grading/Grade_Change_Workflow.html>. Graduate Office Update Dear BME Faculty, Weldon BME PhD students performing research in one of these areas - cardiovascular devices, implantable biomaterials design, drug-delivery systems, or biochemical sensors - are eligible for nomination for the Ronald W. Dollens Scholarship. For the nomination, we will need from you a short description (less than 250 words) of an outstanding, current graduate student in your lab who is excelling in research performance and service to the department. In your description, please mention/include the following: * Student's year in the PhD program (1st year, 2nd year, etc.) * Brief description of outstanding research performance * Brief description of service to the department * Mention of recent awards, presentations made at conferences, papers authored, etc., that you think help describe the student's contributions * Student's CV Please send the nomination to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu> by Sunday, May 21st. The Ronald W. Dollens Scholarships in Life Sciences will be awarded based on academic merit to two deserving graduate students in the Weldon School of Biomedical Engineering who meet the criteria and are selected. The scholarship award is $5,000 with half being awarded in the Fall 2023 semester and half in the Spring 2024 semester. If you have any questions, please don't hesitate to reach out. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Details below. Research Update To safeguard our valuable work and bolster Weldon's standing, it is important that we exercise caution with predatory journals and "hidden" predatory journals. We are collaborating with the Purdue library to organize a session. Stay tuned. https://www.science.org/content/article/fast-growing-open-access-journals-s… https://retractionwatch.com/2023/03/21/nearly-20-hindawi-journals-delisted-… Participants needed for a Motor Function Study, "Development of a Diagnostic System for Assessment of Motor Impairment," IRB# IRB-2022-1299. See below for details. Resources and further information BME PhD Preliminary Exam Announcement for Brendan K. Ball (D. Brubaker, advisor), Mon., May 8, 11:00 a.m., MJIS 2001 and via Zoom. Title: Alzheimer's Disease Pathology Driven by Orexin and Type 2 Diabetes. Committee Members: Doug Brubaker, Ph.D. (Chair), Elizabeth Proctor, Ph.D., Deva Chan, Ph.D., Tamara Kinzer-Ursem, Ph.D., Brendan Lucey, M.D. Abstract: Alzheimer's disease (AD) is the most common form of dementia and is often presented with aggregates of amyloid-β and intracellular tau proteins in the brain, which leads to downstream progressive memory loss and cognitive impairment. Multiple risk factors for AD development include age, genetics, and other pre-existing diseases such as type 2 diabetes (T2D). While up to 81% of people with AD may have T2D or impaired glucose levels, the biological mechanisms by which T2D exacerbates AD pathology are not well-understood. Previous studies shown that orexin, a neuropeptide responsible for appetite, arousal, and wakefulness, to be involved in AD and T2D pathology, which may be a potential link between the two diseases. We propose that protein aggregation in the brain, and metabolic processes regulated by the orexin network and T2D exacerbates AD pathology. To test this idea, we will first identify functional and biological associations of gene expressions via protein interaction networks and gene set enrichment analysis. Second, we will incorporate publicly available mouse, post-mortem human brain tissue, and human cell line transcriptomic data into our computational model to characterize pathways by which proteinopathy, T2D and orexin are predictive of human neuropathological status. Finally, we will quantify neuroinflammatory cytokines and gene expression by performing multiplexing assays and RNA sequencing of primary neuron samples after stimulation with disease-associated metabolites and orexin antagonist. Upon completion of this study, we will have improved our understanding on biological mechanisms in which orexin and T2D exacerbates AD pathology, which may introduce avenues for disease-directed therapeutics. Zoom Link: https://purdue-edu.zoom.us/j/5554725555 BME PhD Defense Announcement for James K. Nolan (H. Lee, advisor), Wed., May 10, 1:30 p.m., DLR 131. Title: Multi-Analyte Biosensing with Enzymatic Electrochemical Sensors. Committee: Hyowon Lee, Chair; Aaron B. Bowman; Chi Hwan Lee; Jacqueline Linnes Abstract: Electrochemical biosensor arrays been integrated into microfluidic cell culture platforms have measured metabolic markers, proteins, and nucleic acids. There is a gap for electrochemical biosensor lab on a chip for simultaneously monitoring multiple neurotransmitters, such as glutamate and dopamine, while compatible with recombinant fluorescent neurotransmitter and epigenetic biosensors. A microfluidic neuronal cell-culture platform with these capabilities would be a valuable tool for quantifying phenotypes of PD-linked epigenetic change resulting from environmental chemical exposure. To this end, we aim to develop arrays of enzymatic electrochemical sensors for multi-analyte biosensing. We have developed sensors using direct ink writing robotic printing and conventional thin film processing that can simultaneously measure neurotransmitters (glutamate) and metabolic biomarkers (glucose and lactate) together simultaneously in cell culture media. We have also shown the biocompatibility of theses sensors for neuronal cell culture. What remains to do is verify their stability during many weeks exposure to cell culture conditions and to demonstrate glutamate measurement from glutaminergic neurons in a microfluidic chip. BME PhD Preliminary Exam Announcement for Michael Zimmerman (A. Chubykin and K. Jayant, co-advisors). Everyone is invited to attend the public presentation on Wed., May 10, beginning at 2:00 pm in LILY G456 and via Zoom. Title: Understanding Learning and Memory: The Role of Neural Oscillations. Committee: Dr. Alexander Chubykin (Primary advisor), Dr. Krishna Jayant (Co-advisor). Dr. Maria Dadarlat, Dr. Edward Bartlett Abstract: Autism spectrum disorder (ASD) is an extremely prevalent group of neurodevelopmental disorders that affects 2% of the population worldwide. Many of the symptoms of ASD emerge as difficulties with social communication or other comorbidities such as mood disorders and epilepsy. A hallmark of ASD is disruption of sensory processing and filtering that is associated with either hyper- or hyposensitivity which impacts social interaction, daily functioning, and learning and memory. Currently, the underlying mechanism causing this disruption has yet to be understood. Fragile X Syndrome (FX) is the most common monogenetic form of ASD, accounting for approximately 5% of all cases, and is a prime model for investigating this disruption. This work takes advantage of emerging novel technologies and paradigms to unravel an underlying mechanism behind learning and memory and its impairment in FX. I find that low frequency theta oscillations emerge following familiarity in both the primary visual cortex (V1) and hippocampus, which is known to encode memory, yet are primarily formed in V1. Additionally, with an active learning behavior paradigm, these oscillations are modified between stimuli and consistently weaker in FX mice, suggesting they encode more than just familiarity. Finally, I propose future work that will utilize optogenetic stimulation to further investigate the role of these oscillations, and potentially identify a future therapy for ASDs. Overall, this work is investigating the role of theta oscillations across the brain to understand their function in memory formation and encoding while also testing a potential therapeutic treatment for learning disability. Zoom link: https://purdue-edu.zoom.us/j/91953591881 Diabetes Research Virtual Seminar Series, Wed., May 10, 2:00 p.m., via Zoom. Katalin Susztak, MD, PhD, Professor of Medicine & Genetics, Director of Penn/CHOP Kidney Innovation Center, University of Pennsylvania, will present "Shifting Focus in Diabetes Care: Moving from Glucose Control to Complications Prevention." Abstract: Kidney disease is a major driver of mortality among patients with diabetes and diabetic kidney disease (DKD) responsible for close to half of all chronic kidney disease cases. DKD usually develops in a genetically susceptible individual as a result of poor metabolic (glycemic) control. Newly identified molecular pathways could provide the basis for the development of much-needed novel therapeutics. This seminar series is organized by the Diabetes Research Centers and Centers for Diabetes Translation Research. Would you like to meet the speaker immediately following the webinar to speak further about research? You may log in to MEET THE SPEAKER<https://zoom.us/j/95857325830> 3 PM-3:45 PM ET on May 10. Seminar Zoom link: https://zoom.us/j/91323894836 Diabetes Data and Hypothesis Hub (D2H2) Seminar, Fri., May 12, 12:00 p.m., via Zoom. Dr. Avi Ma'ayan will present "The Diabetes Data and Hypothesis Hub (D2H2) and the Playbook Partnership Workflow Builder (PPWB): Bioinformatics Tools for Hypothesis Generation via Data Integration." Register here: https://scgcorp.zoom.us/webinar/register/WN_YgWw6WDTRX6TfaugZ3OBXg Abstract: This seminar will discuss two new interactive bioinformatics software tools that integrate knowledge from many NIH funded and other key resources for hypothesis generation. The Diabetes Data and Hypothesis Hub (D2H2) is a platform that integrates tools and datasets related to diabetes research into one integrative platform. The Playbook Partnership Workflow Builder (PPWB) is a system that enables novice users to created bioinformatics workflows by exploring a network of distributed but connect microservices. These two new tools will be demonstrated through a variety of use cases with applications that prioritize personalized drugs and targets for kidney disease, diabetes, and pan-cancer. Bio: Dr. Ma'ayan is a Mount Sinai Endowed Professor in Bioinformatics, Professor in the Department of Pharmacological Sciences, Director of the Mount Sinai Center for Bioinformatics, and a faculty member of the Department of Artificial Intelligence and Human Health at the Icahn School of Medicine at Mount Sinai in New York City. The Ma'ayan Laboratory applies computational methods to study the complexity of regulatory networks in mammalian cells. His research team develops software systems to help experimental biologists form novel hypotheses from high-throughput data with a focus on drug and target discovery through machine learning and other statistical methods. BME PhD Preliminary Exam Announcement for Shulan Xiao (K. Jayant, advisor), Fri., May 19. Everyone is invited to attend the presentation beginning at 11:00 a.m. in MJIS 2001 and via Zoom. Title: The Biophysical Basis of Sensory Feature Binding in Cortical Pyramidal Neurons. Advisory committee: Krishna Jayant, Chair; Alexander A. Chubykin; Edward L. Bartlett; Fang Huang; Scott R. Pluta Abstract: Feature binding is critical for sensory perception and pattern classification. In cortical layer 2/3 and layer 5 pyramidal neurons (L2/3 and L5 PNs) feedforward inputs synapse onto basal dendritic arbors in distinct spatio-temporal patterns. How these distributed inputs integrate, multiplex, and dictate unique output codes, however, remains poorly mapped. Furthermore, it remains unclear how specific input sequences learn over time to aid pattern classification and whether this plasticity and integration is shaped by top-down feedback. To address these outstanding challenges, I have designed and implemented a new microscope capable of stimulating synapses via 3D transmitter uncaging while simultaneously recording the electrical input-output transformation. Using this platform across in vitro acute slice preparations, I propose to unravel the biophysics of multibranch dendritic integration and feature classification under quiescent and in vivo like states in L5 pyramidal neurons - the primary output layer of the cortex. Here, my aims are focused on dissecting mechanisms that underlie multiplexing across basal dendrites, plasticity mechanisms that assist efficient feature classification, and the role of top-down modulation in shaping basal dendritic integration. I propose innovative methods including two-photon holographic uncaging, dynamic clamp, computational modeling, and in vivo two-photon calcium imaging to test and validate my hypotheses. Successful completion of my aims will lead to a new understanding of how dendritic nonlinearities facilitate efficient feature classification amidst noisy backgrounds in individual L5 PNs, including different subtypes. The outcome of this finding is not only poised to improve our understanding of neural signal processing but could bolster the design of future biologically inspired artificial intelligence-based neuromorphic systems. Zoom link: https://purdue-edu.zoom.us/j/9146700686 Participants Needed for Research Study: (Aditya Shanghavi is a graduate student in Biomedical Engineering at Purdue.) I am currently working on a research project under the direction of my advisor, Dr Anne Sereno. We are inviting you to participate in a brief arm movement study. We are specifically looking for participants aged 45-85 with no history of neurological diseases who are fluent in English and have adequate hearing (with or without amplification) to process verbal instruction and adequate vision to see the computer screen. Participants should be able to perform simple upper arm motions without experiencing major pain or discomfort. We will use non-invasive motion sensors on a wristband to collect arm motion signals during normal and simulated abnormal movements (after viewing short videos) as well as an eye tracker to collect eye motion signals during a prosaccade-antisaccade task. This study's goal is to develop algorithms to detect latencies and amplitudes of movements and to quantify the sensitivity, reliability, and accuracy of the sensors and these algorithms to differentiate normal versus simulated abnormal movements. The study should take no more than 60 minutes and it will be conducted in PSYCH 3125. We will highly appreciate you taking time out of your busy schedule and will compensate you $15 for your help in our research study in addition to our heartfelt gratitude. This study is conducted in accordance with IRB # IRB-2022-1299. If you have more questions regarding this study, please contact Aditya Shanghavi at ashangha(a)purdue.edu<mailto:ashangha@purdue.edu>. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Fall 2023, 3.0 credit hours Wednesdays 11:30-2:20 in MJIS 1083 (in person attendance only) Prerequisite: BME Graduate Standing Course Description: The unique medical needs of pediatric patients in the context of current and emerging clinical technologies are presented in this novel course. Anatomical, physiological, and pathophysiological underpinnings of diseases in infants and children are studied. Unique aspects of pediatric device design, regulation, and translation, including clinical studies and ethical considerations, are explored. Numerous clinical sub specialties such as cardiology, surgery, nephrology, pulmonology, and gastroenterology are examined in terms of technology adoption and remaining clinical needs. Future directions in device development and emerging trends in patient care are considered throughout. Weekly Course Topics: August 23 Pediatrics Introduction August 30 Neonatology Introduction September 6 Pediatric Device Design and Development I September 13 Pediatric Device Design and Development II September 20 Pediatric Device Regulation September 27 Pediatric Clinical Studies October 4 Pediatric Cardiology October 18 Pediatric Cardiovascular Surgery October 25 Pediatric Nephrology November 1 Pediatric Pulmonology November 8 Pediatric Wound Healing November 15 Pediatric Gastroenterology November 29 Ethical Considerations in Pediatrics December 6 Future Directions and Trends Primary Instructor: George Wodicka, MJIS 3036, wodicka(a)purdue.edu Numerous experts from the Indiana University School of Medicine Department of Pediatrics, Riley Hospital for Children, and Cook Medical, Inc. will actively participate. Attachments BME Course Descriptions 2023ClimateSurveyFlyer_Emailing.pdf Course List Fall 2023 Summer Seminar Flyer 2023 -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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BME PhD Preliminary Exam Announcement for Shulan Xiao (K. Jayant, advisor)
by May, Sandra M 05 May '23

05 May '23

BME PhD Preliminary Exam Announcement for Shulan Xiao (K. Jayant, advisor) Everyone is invited to attend the public presentation beginning at 11:00 am. TITLE: THE BIOPHYSICAL BASIS OF SENSORY FEATURE BINDING IN CORTICAL PYRAMIDAL NEURONS Date: May 19th, 2023 Time: 11:00 am Location: MJIS 2001 and Zoom https://purdue-edu.zoom.us/j/9146700686 Advisory committee: Krishna Jayant, Chair; Alexander A. Chubykin; Edward L. Bartlett; Fang Huang; Scott R. Pluta Abstract: Feature binding is critical for sensory perception and pattern classification. In cortical layer 2/3 and layer 5 pyramidal neurons (L2/3 and L5 PNs) feedforward inputs synapse onto basal dendritic arbors in distinct spatio-temporal patterns. How these distributed inputs integrate, multiplex, and dictate unique output codes, however, remains poorly mapped. Furthermore, it remains unclear how specific input sequences learn over time to aid pattern classification and whether this plasticity and integration is shaped by top-down feedback. To address these outstanding challenges, I have designed and implemented a new microscope capable of stimulating synapses via 3D transmitter uncaging while simultaneously recording the electrical input-output transformation. Using this platform across in vitro acute slice preparations, I propose to unravel the biophysics of multibranch dendritic integration and feature classification under quiescent and in vivo like states in L5 pyramidal neurons - the primary output layer of the cortex. Here, my aims are focused on dissecting mechanisms that underlie multiplexing across basal dendrites, plasticity mechanisms that assist efficient feature classification, and the role of top-down modulation in shaping basal dendritic integration. I propose innovative methods including two-photon holographic uncaging, dynamic clamp, computational modeling, and in vivo two-photon calcium imaging to test and validate my hypotheses. Successful completion of my aims will lead to a new understanding of how dendritic nonlinearities facilitate efficient feature classification amidst noisy backgrounds in individual L5 PNs, including different subtypes. The outcome of this finding is not only poised to improve our understanding of neural signal processing but could bolster the design of future biologically inspired artificial intelligence-based neuromorphic systems.

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[Bmeroundtable-list] BME Monday Roundtable - May 1, 2023
by Gelfand, Johanna K 01 May '23

01 May '23

[cid:image003.jpg@01D97C4B.AA086A90] BME MONDAY ROUNDTABLE May 1, 2023 (FINALS WEEK) DEPUTY HEAD'S NOTE May has finally come, which means we are so close to the end of the semester. I just want to wish you a successful end of the semester here! * As you know, Purdue had its annual Day of Giving. In total, the event raised more than $110M. I believe it was the first time a leaderboard was set up to track the amount of money raised by each academic unit. I am so proud that we came in as no. 18 with a total of more than $644K raised in one day. Among the engineering departments, we only trailed the big boys, ECE, ChE, ME, Civil Eng, AAE. I hope we can set a higher target and be strategic and proactive about it for next year. Every penny counts and every penny will come back to supporting our learning, research, and engagement. * We had a wonderful End-of-Year Celebration last Friday, organized by jointly by Purdue BMES and BMEGSA. Thanks to those who put up this event in a short amount of time. Several Undergraduate Scholarships, Graduate Awards, and TA Awards were presented. Congratulations to the graduate students who won the awards. Thanks to the faculty, staff, and graduate students, who worked closely with the undergraduate award recipients. Most importantly, past Friday's event was regarded a de-stress event for students as they were about to enter the Final Exams week. * I personally encourage you to participate in the Weldon School Climate Survey. It is a survey focusing on the issues of diversity, equity, and inclusion. This survey will take about 10 - 15 minutes to complete. Your input is highly valued. We will be able to use the information to guide our DEI efforts over the next year in order to improve the culture of the school. As you know, our school has been a frontrunner on DEI efforts at the college and the university. We want to keep our momentum. Many thanks to Professors Luis Solorio and Elsje Pienaar. If you have questions, please contact them. * Qualifying exams are still under way. Many of the faculty have served with the best of their capacity in these exams. My great appreciation to you especially in this time of the semester. We will continue to collect data and monitor the process. We have expected the adoption of qualifying examination of this form would enhance our PhD students for their preparation in the pursuit of research and professional development. First-year graduate students, I encourage you to reach out to me, Dr. Tami Kinzer-Ursem, and Dr. Mike Heinz if you have questions and comments. The faculty panelists, please do so as well. * We will have our BME faculty/staff Happy Hour on May 17th to celebrate the end of the semester and more importantly, welcome the two new members of the Weldon School. Please come out to have an epic pre-summer celebration. Important MJIS Alert Starting Tuesday, May 16th (NOTE new date!), Martin Jischke Drive will be CLOSED to all traffic. The university will be performing infrastructure repairs in the area. The street will be closed to traffic for most, if not all of the summer. When the street reopens, bike lanes will replace the on-street parking, although we do not currently have details/confirmation on the entire process yet. Stay tuned for additional details. UPCOMING IMPORTANT DATES Week of April 24 Mon., May 1 - Fri., May 5: Final Exams Week. Tues., May 2: BME PhD Preliminary Exam Announcement for Awadh M. Alhawwash (K. Yoshida and H. Lee, co-advisors). Everyone is invited to attend the public presentation beginning at 1:00 PM in IUPUI SL 220A or via Zoom. Title: Exploring Sinusoidal Low Frequency Alternating Currents (LFAC) as a New Modality for Functional Electrical Stimulation. Tues., May 2: Elmore Family School of Electrical & Computer Engineering Distinguished Seminar, 10:30 a.m.-11:45 a.m., WALC 2088 and via Zoom. Stephen A. Boppart, MD, PhD, Professor and Grainger Distinguished Chair in Engineering, University of Illinois, Urbana-Champaign will present "Imaging with Artificial Intelligence for Identifying Optical Biosignatures of Disease using Simultaneous Label-free Auto-fluorescence Multi-harmonic (SLAM) Microscopy." Upcoming important deadlines and info. Mon., May 8: BME PhD Preliminary Exam Announcement for Brendan K. Ball (D. Brubaker, advisor), 11:00 a.m., MJIS 2001 and via Zoom. Title: Alzheimer's Disease Pathology Driven by Orexin and Type 2 Diabetes. Wed., May 10: BME PhD Defense Announcement for James K. Nolan (H. Lee, advisor), 1:30 p.m., DLR 131. Title: Multi-Analyte Biosensing with Enzymatic Electrochemical Sensors. Wed., May 10: BME PhD Preliminary Exam Announcement for Michael Zimmerman (A. Chubykin and K. Jayant, co-advisors). Everyone is invited to attend the public presentation beginning at 2:00 pm in LILY G456 and via Zoom. Title: Understanding Learning and Memory: The Role of Neural Oscillations. Fri., May 12-Sat., May 13: Inaugural Krannert Cardiovascular Research Center Biennial, sponsored by the Indiana University School of Medicine at the JW Marriott and Eiteljorg Museum, Indianapolis, IN. Krannert is conducting a nationally recognized CME event May 12-13 (Fri-Sat) on Myocardial Infarction & Reperfusion Injury. We cordially invite you to join us if possible. We have a strong line up of speakers on the topic who are renowned for their decades of contributions to the field. We are hoping for an event that would capture almost 50 years of activity in the field of ischemia/reperfusion and place it in a context to chart the course forward with the goal of improving care for heart attack patients. This is a great opportunity to meet thought leaders, engage in transformative science, and hopefully be part of a journey to advance CV research. For Program Agenda & Registration, please follow the link: https://medicine.iu.edu/institutes/cardiovascular/research/biennial Fri., May 12: Diabetes Data and Hypothesis Hub (D2H2) Seminar, 12:00 p.m., via Zoom. Dr. Avi Ma'ayan will present "The Diabetes Data and Hypothesis Hub (D2H2) and the Playbook Partnership Workflow Builder (PPWB): Bioinformatics Tools for Hypothesis Generation via Data Integration." Register here: https://scgcorp.zoom.us/webinar/register/WN_YgWw6WDTRX6TfaugZ3OBXg Wed., May 17: BME Summer Seminar Series, 9:30 a.m., via Zoom. The BME Summer Seminar Series will run from May 17th - August 9th. The first week's speakers will be Ruhi Sharmin and Brendan Ball. Full schedule is attached. Thurs., May 25: Application Deadline for Trailblazers in Engineering workshop, to be held on the Purdue campus July 25-26. Trailblazers in Engineering (TBE) is a multi-day workshop focused on preparing future outstanding engineering scholars for future engineering faculty careers who are also committed to increase the success of underrepresented communities of engineers. Trailblazers in Engineering Fellows are selected not only for their outstanding scholarly achievements but also for their potential impact in expanding representation and diversity in engineering. See attached flyer for application instructions. Committee Updates Academic Programs Update Fall 2023 Course Schedule is attached to this email. Drop-in virtual help sessions can assist faculty with end-of-semester Brightspace, other instructional technology - Purdue University Online - Purdue University<https://discover.online.purdue.edu/news/2023/04/05%20-%20Drop-in%20virtual%…> Full Term (16 Weeks) and Second Eight-Week Session grade entry (meeting between March 6 and May 6) begins at 8 a.m. April 21 and ends promptly at 5 p.m. May 9. 1. Now is the perfect time for faculty to take the 15 minutes to get all their required certifications up to date BEFORE the deadline approaches. * FERPA * GLBA * Data Handling * Protecting SSNs 2. This page<https://www.purdue.edu/registrar/faculty/grading/PWL-grade-entry-update.html> provides myPurdue grade entry instructions. 3. This page<https://www.purdue.edu/brightspace/Docs/Grades/SubmitFinalGradesToBanner.php> provides BrightSpace final grade submission instructions. 4. Those not making the deadline can use the Grade Change Workflow. * Instructions may be found here<https://www.purdue.edu/registrar/faculty/grading/Grade_Change_Workflow.html>. 5. Lastly but still very important, any faculty that assigned an Incomplete in Spring 2022 has until Tuesday, May 2 at 5pm to use the Grade Change Workflow to submit a completion grade. If not submitted by this deadline it will revert to an IF grade for the student. * Any extension requests for students that faced obstacles outside of their control should be submitted to @Shomaker, Lori<mailto:lshomake@purdue.edu> no later than Friday, May 5 for processing. Graduate Office Update Dear BME Faculty, Weldon BME PhD students performing research in one of these areas - cardiovascular devices, implantable biomaterials design, drug-delivery systems, or biochemical sensors - are eligible for nomination for the Ronald W. Dollens Scholarship. For the nomination, we will need from you a short description (less than 250 words) of an outstanding, current graduate student in your lab who is excelling in research performance and service to the department. In your description, please mention/include the following: * Student's year in the PhD program (1st year, 2nd year, etc.) * Brief description of outstanding research performance * Brief description of service to the department * Mention of recent awards, presentations made at conferences, papers authored, etc., that you think help describe the student's contributions * Student's CV Please send the nomination to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu> by Sunday, May 21st. The Ronald W. Dollens Scholarships in Life Sciences will be awarded based on academic merit to two deserving graduate students in the Weldon School of Biomedical Engineering who meet the criteria and are selected. The scholarship award is $5,000 with half being awarded in the Fall 2023 semester and half in the Spring 2024 semester. If you have any questions, please don't hesitate to reach out. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Details below. Research Update To safeguard our valuable work and bolster Weldon's standing, it is important that we exercise caution with predatory journals and "hidden" predatory journals. We are collaborating with the Purdue library to organize a session. Stay tuned. https://www.science.org/content/article/fast-growing-open-access-journals-s… https://retractionwatch.com/2023/03/21/nearly-20-hindawi-journals-delisted-… Participants needed for a Motor Function Study, "Development of a Diagnostic System for Assessment of Motor Impairment," IRB# IRB-2022-1299. See below for details. Resources and further information BME PhD Preliminary Exam Announcement for Awadh M. Alhawwash, (K. Yoshida and H. Lee, co-advisors). Everyone is invited to attend the public presentation on Tues., May 2, beginning at 1:00 PM in IUPUI SL 220A or via Zoom. Title: Exploring Sinusoidal Low Frequency Alternating Currents (LFAC) as a New Modality for Functional Electrical Stimulation. Committee members: Dr. Ken Yoshida (Co-advisor), Dr. Hyowon Hugh Lee (Co-advisor), Dr. Edward J. Berbari, Dr. Matthew P. Ward Abstract: Functional Electrical Stimulation (FES) is a promising rehabilitative technology that provides hope for restoring functional movements in patients suffering from paralysis caused by spinal cord injury, stroke, or traumatic brain injury. However, the clinical effectiveness of FES is limited by the simultaneous occurrence of muscle fatigue and excessive metabolic cost resulting from the reversed order of muscle fiber recruitment of conventional pulse stimulation. In this project, we propose the use of sinusoidal low frequency alternating current (LFAC) stimulation as a novel motor nerve stimulation method. Our pilot study in a rabbit model showed that LFAC stimulation induced long-lasting non-fatiguing muscle contractions, necessitating further investigation. This research aims to explore and comprehensively analyze the muscle contractions elicited by LFAC stimulation using cuff electrodes. Electrodes are placed on the sciatic nerve of anesthetized rats to evoke motor activity using pulse and LFAC stimulation. The order of motor unit recruitment and rate of muscle fatigue are compared for LFAC and pulse stimulation. The initial results indicate that the muscle is activated by LFAC stimulation. The EMG activity was phase-locked to the sinusoidal cycle but exhibited two distinct phenotypes: burst and unitary. The LFAC activation threshold was frequency-dependent and influenced by the cuff electrode geometry. The soleus muscle, mediated by smaller caliber alpha motor neurons, generally had a lower LFAC activation threshold than the lateral gastrocnemius, mediated by larger caliber alpha motor neurons. This finding suggests a normal "physiological" recruitment order is obtained using LFAC stimulation. A comparison of fatigue rate between pulse and LFAC stimulation is pending, but initial indications are that LFAC-based stimulation has greater fatigue resistance but greater force production variability. Systematic characterization of LFAC-based motor nerve stimulation aims to provide empirical evidence to identify the mechanism and locus of action of LFAC stimulation. This will establish a foundation for LFAC to be developed as a new modality in the field of neuromodulation, with the potential to overcome limitations and enhance the effectiveness and usability of FES technology. Zoom link: https://purdue-edu.zoom.us/j/91256810994?pwd=ai9qR3EvWndIRW9paEx3eE4yM2RjZz… * *Zoom meeting additional information: Meeting ID: 912 5681 0994 Passcode: 860596 One tap mobile +13092053325,,91256810994#,,,,*860596# US +13126266799,,91256810994#,,,,*860596# US (Chicago) Dial by your location +1 309 205 3325 US +1 312 626 6799 US (Chicago) +1 646 558 8656 US (New York) +1 646 931 3860 US +1 301 715 8592 US (Washington DC) +1 305 224 1968 US +1 360 209 5623 US +1 386 347 5053 US +1 507 473 4847 US +1 564 217 2000 US +1 669 444 9171 US +1 669 900 6833 US (San Jose) +1 689 278 1000 US +1 719 359 4580 US +1 253 205 0468 US +1 253 215 8782 US (Tacoma) +1 346 248 7799 US (Houston) Meeting ID: 912 5681 0994 Passcode: 860596 Find your local number: https://purdue-edu.zoom.us/u/acjXQSfaK Join by SIP 91256810994(a)zoomcrc.com<mailto:91256810994@zoomcrc.com> Join by H.323 162.255.37.11 (US West) 162.255.36.11 (US East) Meeting ID: 912 5681 0994 Passcode: 860596 Elmore Family School of Electrical & Computer Engineering Distinguished Seminar, Tues., May 2, 10:30 a.m.-11:45 a.m., WALC 2088 and via Zoom. Stephen A. Boppart, MD, PhD, Professor and Grainger Distinguished Chair in Engineering, University of Illinois, Urbana-Champaign will present "Imaging with Artificial Intelligence for Identifying Optical Biosignatures of Disease using Simultaneous Label-free Auto-fluorescence Multi-harmonic (SLAM) Microscopy." Abstract: Label-free intravital optical imaging and imaging of fresh, unstained, resected tissue specimens, offers a wealth of new biosignatures for revealing the true colors of cancer and diagnosing neurodegenerative changes. Using new optical source technology and nonlinear optics to generate new excitation wavelengths and manipulate the light stimulus in new ways, Simultaneous Label-free Auto-fluorescence Multi-harmonic (SLAM) microscopy can achieve fast simultaneous visualization of the rich intrinsic molecular and metabolic features within tissues. Quantitative machine/deep learning analyses of these multi-dimensional datasets can be used to identify selective diagnostic biosignatures for disease. Specifically, extracellular vesicles (EVs) in carcinogenesis and plaque composition in Alzheimer's disease were analyzed via their optical signatures and spatial distributions. Analysis showed that EVs from the tumor microenvironment and variations in amyloid-beta plaques have unique optical signatures, in comparison to those vesicles and tissues from healthy subjects. The clinical demonstration of these optical biomedical imaging technologies offers new paradigms for point-of-procedure diagnosis and guidance. Bio: Stephen Boppart is a Professor and Grainger Distinguished Chair in Engineering at the University of Illinois Urbana-Champaign (UIUC) with appointments in the Departments of Electrical and Computer Engineering, Bioengineering, the Carle Illinois College of Medicine, and the Beckman Institute for Advanced Science and Technology. His Biophotonics Imaging Laboratory is focused on developing novel optical biomedical diagnostic and imaging technologies and translating these into clinical applications. Prof. Boppart received his Ph.D. in Medical and Electrical Engineering from MIT, his M.D. from Harvard Medical School. Prof. Boppart has been a strong advocate for the integration of engineering, technology, and medicine to advance human health and our healthcare systems. He played an active role in the initiation, visioning, launch, and growth of the new engineering-based Carle Illinois College of Medicine at the University of Illinois Urbana-Champaign, and served as Executive Associate Dean and Chief Diversity Officer. Currently he is serving as the Interim Director for the university's Interdisciplinary Health Sciences Institute, and as the Illinois Co-Chair of the Mayo Clinic & Illinois Alliance for Technology-Based Healthcare. He is also leading the Chancellor's charge to develop a new cross-campus model for research and education in technology-inspired health innovation. Host: Prof. Meng Cui Zoom link: https://purdue-edu.zoom.us/j/99256954527 BME PhD Preliminary Exam Announcement for Brendan K. Ball (D. Brubaker, advisor), Mon., May 8, 11:00 a.m., MJIS 2001 and via Zoom. Title: Alzheimer's Disease Pathology Driven by Orexin and Type 2 Diabetes. Committee Members: Doug Brubaker, Ph.D. (Chair), Elizabeth Proctor, Ph.D., Deva Chan, Ph.D., Tamara Kinzer-Ursem, Ph.D., Brendan Lucey, M.D. Abstract: Alzheimer's disease (AD) is the most common form of dementia and is often presented with aggregates of amyloid-β and intracellular tau proteins in the brain, which leads to downstream progressive memory loss and cognitive impairment. Multiple risk factors for AD development include age, genetics, and other pre-existing diseases such as type 2 diabetes (T2D). While up to 81% of people with AD may have T2D or impaired glucose levels, the biological mechanisms by which T2D exacerbates AD pathology are not well-understood. Previous studies shown that orexin, a neuropeptide responsible for appetite, arousal, and wakefulness, to be involved in AD and T2D pathology, which may be a potential link between the two diseases. We propose that protein aggregation in the brain, and metabolic processes regulated by the orexin network and T2D exacerbates AD pathology. To test this idea, we will first identify functional and biological associations of gene expressions via protein interaction networks and gene set enrichment analysis. Second, we will incorporate publicly available mouse, post-mortem human brain tissue, and human cell line transcriptomic data into our computational model to characterize pathways by which proteinopathy, T2D and orexin are predictive of human neuropathological status. Finally, we will quantify neuroinflammatory cytokines and gene expression by performing multiplexing assays and RNA sequencing of primary neuron samples after stimulation with disease-associated metabolites and orexin antagonist. Upon completion of this study, we will have improved our understanding on biological mechanisms in which orexin and T2D exacerbates AD pathology, which may introduce avenues for disease-directed therapeutics. Zoom Link: https://purdue-edu.zoom.us/j/5554725555 BME PhD Defense Announcement for James K. Nolan (H. Lee, advisor), Wed., May 10, 1:30 p.m., DLR 131. Title: Multi-Analyte Biosensing with Enzymatic Electrochemical Sensors. Committee: Hyowon Lee, Chair; Aaron B. Bowman; Chi Hwan Lee; Jacqueline Linnes Abstract: Electrochemical biosensor arrays been integrated into microfluidic cell culture platforms have measured metabolic markers, proteins, and nucleic acids. There is a gap for electrochemical biosensor lab on a chip for simultaneously monitoring multiple neurotransmitters, such as glutamate and dopamine, while compatible with recombinant fluorescent neurotransmitter and epigenetic biosensors. A microfluidic neuronal cell-culture platform with these capabilities would be a valuable tool for quantifying phenotypes of PD-linked epigenetic change resulting from environmental chemical exposure. To this end, we aim to develop arrays of enzymatic electrochemical sensors for multi-analyte biosensing. We have developed sensors using direct ink writing robotic printing and conventional thin film processing that can simultaneously measure neurotransmitters (glutamate) and metabolic biomarkers (glucose and lactate) together simultaneously in cell culture media. We have also shown the biocompatibility of theses sensors for neuronal cell culture. What remains to do is verify their stability during many weeks exposure to cell culture conditions and to demonstrate glutamate measurement from glutaminergic neurons in a microfluidic chip. BME PhD Preliminary Exam Announcement for Michael Zimmerman (A. Chubykin and K. Jayant, co-advisors). Everyone is invited to attend the public presentation on Wed., May 10, beginning at 2:00 pm in LILY G456 and via Zoom. Title: Understanding Learning and Memory: The Role of Neural Oscillations. Committee: Dr. Alexander Chubykin (Primary advisor), Dr. Krishna Jayant (Co-advisor). Dr. Maria Dadarlat, Dr. Edward Bartlett Abstract: Autism spectrum disorder (ASD) is an extremely prevalent group of neurodevelopmental disorders that affects 2% of the population worldwide. Many of the symptoms of ASD emerge as difficulties with social communication or other comorbidities such as mood disorders and epilepsy. A hallmark of ASD is disruption of sensory processing and filtering that is associated with either hyper- or hyposensitivity which impacts social interaction, daily functioning, and learning and memory. Currently, the underlying mechanism causing this disruption has yet to be understood. Fragile X Syndrome (FX) is the most common monogenetic form of ASD, accounting for approximately 5% of all cases, and is a prime model for investigating this disruption. This work takes advantage of emerging novel technologies and paradigms to unravel an underlying mechanism behind learning and memory and its impairment in FX. I find that low frequency theta oscillations emerge following familiarity in both the primary visual cortex (V1) and hippocampus, which is known to encode memory, yet are primarily formed in V1. Additionally, with an active learning behavior paradigm, these oscillations are modified between stimuli and consistently weaker in FX mice, suggesting they encode more than just familiarity. Finally, I propose future work that will utilize optogenetic stimulation to further investigate the role of these oscillations, and potentially identify a future therapy for ASDs. Overall, this work is investigating the role of theta oscillations across the brain to understand their function in memory formation and encoding while also testing a potential therapeutic treatment for learning disability. Zoom link: https://purdue-edu.zoom.us/j/91953591881 Diabetes Data and Hypothesis Hub (D2H2) Seminar, Fri., May 12, 12:00 p.m., via Zoom. Dr. Avi Ma'ayan will present "The Diabetes Data and Hypothesis Hub (D2H2) and the Playbook Partnership Workflow Builder (PPWB): Bioinformatics Tools for Hypothesis Generation via Data Integration." Register here: https://scgcorp.zoom.us/webinar/register/WN_YgWw6WDTRX6TfaugZ3OBXg Abstract: This seminar will discuss two new interactive bioinformatics software tools that integrate knowledge from many NIH funded and other key resources for hypothesis generation. The Diabetes Data and Hypothesis Hub (D2H2) is a platform that integrates tools and datasets related to diabetes research into one integrative platform. The Playbook Partnership Workflow Builder (PPWB) is a system that enables novice users to created bioinformatics workflows by exploring a network of distributed but connect microservices. These two new tools will be demonstrated through a variety of use cases with applications that prioritize personalized drugs and targets for kidney disease, diabetes, and pan-cancer. Bio: Dr. Ma'ayan is a Mount Sinai Endowed Professor in Bioinformatics, Professor in the Department of Pharmacological Sciences, Director of the Mount Sinai Center for Bioinformatics, and a faculty member of the Department of Artificial Intelligence and Human Health at the Icahn School of Medicine at Mount Sinai in New York City. The Ma'ayan Laboratory applies computational methods to study the complexity of regulatory networks in mammalian cells. His research team develops software systems to help experimental biologists form novel hypotheses from high-throughput data with a focus on drug and target discovery through machine learning and other statistical methods. Participants Needed for Research Study: (Aditya Shanghavi is a graduate student in Biomedical Engineering at Purdue.) I am currently working on a research project under the direction of my advisor, Dr Anne Sereno. We are inviting you to participate in a brief arm movement study. We are specifically looking for participants aged 45-85 with no history of neurological diseases who are fluent in English and have adequate hearing (with or without amplification) to process verbal instruction and adequate vision to see the computer screen. Participants should be able to perform simple upper arm motions without experiencing major pain or discomfort. We will use non-invasive motion sensors on a wristband to collect arm motion signals during normal and simulated abnormal movements (after viewing short videos) as well as an eye tracker to collect eye motion signals during a prosaccade-antisaccade task. This study's goal is to develop algorithms to detect latencies and amplitudes of movements and to quantify the sensitivity, reliability, and accuracy of the sensors and these algorithms to differentiate normal versus simulated abnormal movements. The study should take no more than 60 minutes and it will be conducted in PSYCH 3125. We will highly appreciate you taking time out of your busy schedule and will compensate you $15 for your help in our research study in addition to our heartfelt gratitude. This study is conducted in accordance with IRB # IRB-2022-1299. If you have more questions regarding this study, please contact Aditya Shanghavi at ashangha(a)purdue.edu<mailto:ashangha@purdue.edu>. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Fall 2023, 3.0 credit hours Wednesdays 11:30-2:20 in MJIS 1083 (in person attendance only) Prerequisite: BME Graduate Standing Course Description: The unique medical needs of pediatric patients in the context of current and emerging clinical technologies are presented in this novel course. Anatomical, physiological, and pathophysiological underpinnings of diseases in infants and children are studied. Unique aspects of pediatric device design, regulation, and translation, including clinical studies and ethical considerations, are explored. Numerous clinical sub specialties such as cardiology, surgery, nephrology, pulmonology, and gastroenterology are examined in terms of technology adoption and remaining clinical needs. Future directions in device development and emerging trends in patient care are considered throughout. Weekly Course Topics: August 23 Pediatrics Introduction August 30 Neonatology Introduction September 6 Pediatric Device Design and Development I September 13 Pediatric Device Design and Development II September 20 Pediatric Device Regulation September 27 Pediatric Clinical Studies October 4 Pediatric Cardiology October 18 Pediatric Cardiovascular Surgery October 25 Pediatric Nephrology November 1 Pediatric Pulmonology November 8 Pediatric Wound Healing November 15 Pediatric Gastroenterology November 29 Ethical Considerations in Pediatrics December 6 Future Directions and Trends Primary Instructor: George Wodicka, MJIS 3036, wodicka(a)purdue.edu Numerous experts from the Indiana University School of Medicine Department of Pediatrics, Riley Hospital for Children, and Cook Medical, Inc. will actively participate. Attachments BME Course Descriptions 2023ClimateSurveyFlyer_Emailing.pdf Course List Fall 2023 Summer Seminar Flyer 2023 -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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