[cid:image003.png@01DA94AC.3103CF70] BME WEEKLY ROUNDTABLE April 22, 2024 LAST WEEK OF CLASSES! INTERIM HEAD'S NOTE This week is the quiet period. It occurs during the last Monday through Saturday of the instruction period preceding the final examination period. This is a friendly reminder. Please follow the Quiet Period policies, https://www.purdue.edu/innovativelearning/teaching/module/policies/. It is important to keep a close watch on students' mental health. Quiet period means we are coming to the end of the semester. This is also the awards season and season for giving. Purdue Day of Giving is this Wednesday, April 24. Here is a list of the faculty and student awards I have been made aware of. I plan to do it in the next couple of Roundtables as well. Please let me know if I have missed any. I want to highlight all the accomplishments our people have made this year (not in any particular order). Scott Malloy and Victoria Sinfield received the Magoon Teaching Award, Seokkyoon Hong received the BME Outstanding Graduate Research Award, Juan Mesa received the BME Outstanding Service Scholarship, Aditya Shangavi, Emilee Madsen, Ankit Shah, and Folk Narongrit received Lamp Scholarships for Excellence in Teaching in Biomedical Engineering, Elnaz Ghajar-Rahimi received the Bilsland Dissertation Award, and Timothy (Brock) Beauclair received the Teaching Academy Graduate Teaching Award. Dr. Tamara Kinzer-Ursem received the Dean H.T. Yang Faculty Excellence Award for Leadership in Service. Dr. Jacqueline Linnes received the Faculty Excellence Award for Graduate Student Mentorship. We had our last meeting of the working group on teaching. We came back to the focus we started, i.e., teaching assignments. We made some decisions on getting additional information from the faculty that is expected to facilitate the assignment. An email was sent to you this morning by Jo on behalf of Vitaliy. For the end-of-the semester mini-retreat in Lafayette County Club from 2 to 5 pm on 5/3 (Friday), we have received overwhelming interest. We will have a big party with more than 40 people. Jo and Rhonda have developed an exciting agenda and prepared some fun activities. UPCOMING IMPORTANT DATES Week of April 22 Mon., April 22: Center for Diabetes and Metabolic Diseases Research Seminar Series, 12:00 noon, R4-101 (Indianapolis) and via Zoom. Schafer Boeder, MD, Assistant Professor of Medicine, University of California, San Diego Division of Endocrinology and Metabolism, will speak on "Combination Insulin Adjunctive Therapy to Address Unmet Needs in Type 1 Diabetes." Zoom link: https://iu.zoom.us/j/87501979533#success<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fiu.zoom.us%2Fj%2F87501979533%23success&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C5be193e13aea4c4e9e9808dc62e4db5f%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638493983124541006%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=zT%2BldbNMRdgkGtxsZlCFpOWf1MvspRqc9qiki9JMbsk%3D&reserved=0> This seminar series is sponsored by the Indiana University School of Medicine and the Center for Diabetes and Metabolic Diseases. Wed., April 24: PhD Preliminary Exam Announcement for Rachel Stingel (R. Shi, advisor). Everyone is invited to attend the public presentation beginning at 9:00 AM EDT in MJIS 2001 and via Zoom. Title: Acrolein-mediated excitotoxicity following spinal cord injury Wed., April 24: BME Distinguished Research Seminar Series, 9:30 a.m., MRGN 121 and via Zoom. Stacey D. Finley, PhD, Nichold A. and Thuan Q. Pham Professor, University of Southern California will present "Exploring the tumor ecosystem: Modeling across scales." Wed., April 24: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131 and via Zoom. George Smith, PhD, Professor and Vice Chair, Department of Neural Sciences; Interim Director, Shriner's Children Hospitals Pediatric Research Center; Professor of Bioengineering, Lewis Katz School of Medicine at Temple University will present "Rehabilitation Induces Adaptation of Motor Control Pathways after SCI." Thurs., April 25: Seminars in Hearing Research, 12:00 p.m., Nelson Hall Room 1215. Elle O'Brien, PhD, University of Michigan, will present "How will generative AI change scientific software?" Thurs., April 25: BMS 692/CPB 697 Graduate Seminar, 12:30 p.m., LYNN 1136. Four graduate students will be presenting their research at the BMS 692/CPB 697 graduate course, including one of our very own BME graduate students, Tuba Marjan. Here is the complete listing: "Presumptive Localized Histiocytic Sarcoma in a Dog" by Camila Benaduce E. Mello - Resident, CPB; "Age-Related Differences in Mouse Brain Lipidome" by Punyatoya Panda - Graduate Student, CPB; "Hydrogel Platform with Tunable Biochemical Properties to Study Cell-Matrix Interactions" by Tuba Marjan - Graduate Student, BME; and "Advancing Prey-Predator Models with AI-Enhanced Simulations" by Marwa Ali - Graduate Student, CPB. MJIS END OF SEMESTER ALERTS/REMINDERS Just a quick reminder of a few MJIS policies as we approach the chaos that is the end of the semester. (1) Do not give access (e.g., open a door, prop a door) to anyone you do not know into the secure lab block or any office or meeting room. If there is someone you do not recognize, feel free to call/text Susan Hardy and let her know. Vendors or service personnel should always be invited and escorted by a BME staff or faculty member, and should not be in the building after (or before) normal working hours. Purdue service personnel should always identify themselves and their purpose for being in MJIS. (2) Do not leave office doors unlocked or personal items (backpacks, purses, laptops) unattended. Unfortunately, this is the time of year when individuals come on to our campus to take advantage of distractions associated with the semester ending. We have had personal items stolen in the past. Don't become a victim! GRADING DEADLINES Dear BME faculty, It's crazy to believe the end of the Spring term is just around the corner and final grading opens THIS WEEK. This is the perfect time to ensure your web certifications are current so you don't get stuck during a deadline. FERPA, GLBA, Protecting SSNs, and Data Handling all must be current at the time of grade entry to prevent any roadblocks. Full Term (meets January 8 through May 4) and Second Eight Weeks (meets March 4 through May 4) Grade entry begins at 8 a.m. April 22 and ends at 5 p.m. May 7. Grading Instructions INB or myPurdue grading instructions are here: https://www.purdue.edu/registrar/faculty/gradingPWL-grade-entry-update.html<https://www.purdue.edu/registrar/faculty/grading/PWL-grade-entry-update.html>. The full grading policy can be found here: https://catalog.purdue.edu/content.php?catoid=16&navoid=19719#grades-and-gra... Grading questions: Contact the Office of the Registrar by calling (765) 494-6165 or sending an e-mail to registrar@purdue.edu<mailto:registrar@purdue.edu> GRADUATE PROGRAM UPDATES Our BME Graduate Committee has been hard at work this year overseeing and evaluating our Graduate Programs and developing policies and statements to help with continuous improvements. Please review the slides (attached) to get a glimpse of the work and learn about several significant policy outcomes including the attached policy statement about AI use in Grad Programs Exams and Evaluations. Upcoming important deadlines and information Mon., April 29: BME PhD Preliminary Exam Announcement for Thejas Vishnu Ramesh (J. Rispoli and V. Rayz, advisors). Everyone is invited to attend the public presentation beginning at 2:00 PM in MJIS 2001 and via Zoom. Research title: Conductive fabric based wearable coil for cervical spine and carotid arteries MRI at 3T. Tues., April 30: Neil Armstrong Distinguished Visiting Professors, 3:00 p.m., WALC 1018. Dr. Ronald Latanision, Sennior Fellow, Exponent, Inc. and Neail Armstrong Distinguished Visiting Professor, School of Industrial Engineering, will present "The Evolution of the Materials Genome Initiative." There will be a reception following the seminar, from 4:00-4:30 p.m. More information at https://engineering.purdue.edu/NADVP?utm_source=delivra&utm_medium=email&utm... Thurs., May 2: Neil Armstrong Distinguished Visiting Professors, 2:40-3:20 p.m., STEW 218. Professor Mordechai Segev, Robert J. Shillman Distinguished Professor of Physics and Electrical Engineering, Technion, Israel, and Neil Armstrong Distinguished Visiting Professor, The Elmore Family School of Electrical and Computer Engineering, Purdue will present "Light-Matter Interactions in Photonic Time-Crystals" as part of the 4th Annual Quantum Summer School, The Quantum Science Center, hosted by Purdue. For more information: https://engineering.purdue.edu/NADVP?utm_source=delivra&utm_medium=email&utm... Tues., May 7: BME PhD Defense Announcement for Vidhya Vijayakrishnan Nair (Yunjie Tong, advisor). Everyone is invited to attend the public presentation beginning at 9:00 AM in MJIS 2001 and via Zoom. Research title: Human Cerebrospinal Fluid Movement across Wake and Sleep States - A Multimodal Imaging Study Thurs., May 9: IBSC-BME Preliminary Exam Announcement for Eric J. Tan (Tamara Kinzer-Ursem, advisor), 2:30 p.m., MJIS 2001. This preliminary exam is open only to those who have signed the Lilly NDA. Title: Developing ultrasensitive point-of-care detection of hyper-phosphorylated tau in patients with preclinical Alzheimer's disease. Committee: Tamara L. Kinzer-Ursem, Chair; Jacqueline Linnes; Jean-Christophe Rochet; Scott C. Bolton Fri., June 7: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor, Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Resources and further information Wed., April 24: PhD Preliminary Exam Announcement for Rachel Stingel (R. Shi, advisor). Everyone is invited to attend the public presentation beginning at 9:00 AM EDT in MJIS 2001 and via Zoom. Title: Acrolein-mediated excitotoxicity following spinal cord injury Committee: Riyi Shi (Chair, advisor), Hyowon (Hugh) Lee, Maria Dadarlat, George M. Smith Abstract: Traumatic spinal cord injury (SCI) causes significant sensory, motor, and autonomic dysfunction for which no established treatment option is available. As such, mechanistic investigation is needed to identify effective therapeutic targets to improve the management of SCI. SCI arises from an initial mechanical impact to the spinal cord (primary injury) and is followed by a series of biochemical cascades (secondary injury) that perpetuate the extent of damage. Oxidative stress and glutamate excitotoxicity are two particularly destructive events that manifest within the first two weeks of SCI. Oxidative stress induces lipid peroxidation (LPO), which results in the production of reactive aldehydes (RA) such as acrolein. Acrolein, a strong electrophile that perpetuates oxidative stress, can bind to and cause irreversible structural changes in target proteins. Glutamate transporter-1 (GLT-1), the chief regulator of extracellular glutamate levels, contains a number of nucleophilic amino acid residues that are likely targets of acrolein. Due to its high reactivity and peak levels coinciding with the progression of excitotoxicity, we hypothesize that acrolein binds to and disrupts the function of GLT-1, which underlies excitotoxicity in the secondary injury. Additionally, we have recently found evidence that acrolein damages aldehyde dehydrogenase 2 (ALDH2), an oxidoreductase that metabolizes RAs, making it largely ineffective in neurotraumatic states. We hypothesize that restoring ALDH2 function will reduce acrolein levels and rescue GLT-1, thereby mitigating excitotoxic damage. Completion of these studies will not only better our overall understanding of the mechanisms underlying secondary SCI, but could also be applied to other neurotraumatic injuries or degenerative diseases with similar underlying pathologies. Zoom link for those who cannot attend: meeting ID: 495 923 5472, https://purdue-edu.zoom.us/j/4959235472<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F4959235472&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C5be193e13aea4c4e9e9808dc62e4db5f%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638493983124541006%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=NyFDC5DocuvbfrQjDWmjxDjriEUVNNKWYHgn16YfnCo%3D&reserved=0> Wed., April 24: BME Distinguished Research Seminar Series, 9:30 a.m., MRGN 121 and via Zoom. Stacey D. Finley, PhD, Nichole A. and Thuan Q. Pham Professor, University of Southern California will present "Exploring the tumor ecosystem: Modeling across scales." Abstract: My research group works in the area of mathematical oncology, where we use mathematical models to decipher the complex networks of reactions inside of cancer cells and interactions between cells. We have combined detailed, mechanistic and data-driven modeling to study these networks and predict ways to control tumor growth. Our models generate novel mechanistic insight into cell behavior and predict the effects of strategies aimed at inhibiting tumor growth. We have also developed methods of calibrating the models to tumor image data to generate reliable predictive frameworks. In this talk, I will present our work to model the tumor ecosystem across scales: intracellular signaling of immune cells, evolution of cell states, and interactions between tumor and immune cells using agent-based models. Biography: Dr. Stacey Finley is the inaugural Nichole A. and Thuan Q. Pham Professor at the University of Southern California. She is Professor of Biomedical Engineering and Quantitative and Computational Biology. Dr. Finley received her B.S. in Chemical Engineering from Florida A & M University and obtained her Ph.D. in Chemical Engineering from Northwestern University. She completed postdoctoral training at Johns Hopkins University in the Department of Biomedical Engineering. Dr. Finley joined the faculty at USC in 2013, and she leads the Computational Systems Biology Laboratory. Dr. Finley has a joint appointment in the Department of Chemical Engineering and Materials Science, and she is a member of the USC Norris Comprehensive Cancer Center. Dr. Finley is also a standing member of the MABS Study Section at NIH. Her research has been supported by grants from the NSF, NIH, and American Cancer Society. Selected honors. 2016 NSF Faculty Early CAREER Award; 2016 Young Innovator by the Cellular and Molecular Bioengineering journal; Leah Edelstein-Keshet Prize from the Society of Mathematical Biology; Junior Research Award from the USC Viterbi School of Engineering; the Hanna Reisler Mentorship Award; 2018 AACR NextGen Star; 2018 Orange County Engineering Council Outstanding Young Engineer; 2021 Elected Fellow of American Institute for Biological and Medical Engineering; 2022 Fellow of the Biomedical Engineering Society ~ BME Host: Leo Green ~ ZOOM LINK: https://purdue-edu.zoom.us/j/98872914779<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F98872914779&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C5be193e13aea4c4e9e9808dc62e4db5f%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638493983124541006%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=PELcmDotUPc4QimRkl1tt1Ko%2FFbZWrsVB%2B4BH05ZjiY%3D&reserved=0> *Students registered for the seminar are expected to attend in-person. Wed., April 24: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131 and via Zoom. George Smith, PhD, Professor and Vice Chair, Department of Neural Sciences; Interim Director, Shriner's Children Hospitals Pediatric Research Center; Professor of Bioengineering, Lewis Katz School of Medicine at Temple University will present "Rehabilitation Induces Adaptation of Motor Control Pathways after SCI." Abstract: Approximately 18,000 patients each year are affected by spinal cord injury causing motor, sensory and autonomic dysfunction. Children 16 years of age or younger account for 5% of cases with the majority being cervical level that effect forelimb function. To improve their current lifestyle, patients affected by SCI desire return of hand and digit function. However, most spinal cord injury studies examined recovery of locomotion after thoracic lesions in adults and not goal-directed or skilled forelimb movements after cervical injuries, especially in younger animals. In general, the corticospinal tract drives skilled forelimb movements with support from indirect brainstem regions. After lesions to the corticospinal tract there is a significant loss of forelimb function. Our data shows good recovery in juvenile rats when modulated by altering the excitation of the forelimb motor cortex using chemogenetic channels during play which provided a form of physical and social enrichment. Here expression of Designer Receptors Exclusively Activated by Designer Drugs (Dreadds) showed a hierarchy of recovery of forelimb function. Excitatory Dreadds showed the best recover with significant increases in recover above control levels, whereas reduced recovery below control levels was observed when inhibitory Dreadds were expressed within the motor cortex of lesioned CST axons. Likewise, we saw a similar recovery in forelimb kinematics and muscle activity, in which expression of excitatory Dreadds in cortical motor neurons showed the best recovery, followed by mCherry controls with expression of inhibitory Dreadds showing the poorest outcome. We hypothesize that cortical activity modulates axonal sprouting of the lesioned CST, while physical play shapes the connects to promote circuit adaptation rerouting motor commands through brainstem and propriospinal motor systems. We further show that these brainstem and propriospinal networks are involved in relaying the motor command around the spinal cord lesions. Following these circuits, we have developed a novel approach to motor control theory and circuits involved in motor learning supporting rehabilitation. Zoom link: http://bit.ly/42hhhJG<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fbit.ly%2F42hhhJG&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C5be193e13aea4c4e9e9808dc62e4db5f%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638493983124541006%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=cCeCILg0EmKTiNNpx2k1nWzqPL2OzOEfCVjp7M0GV7g%3D&reserved=0> (Meeting ID: 923 5486 2062, Passcode: CPR. This seminar is sponsored by Purdue's Center for Paralysis Research and Plexon. Thurs., April 25: Seminars in Hearing Research, 12:00 p.m., Nelson Hall Room 1215. Elle O'Brien, PhD, University of Michigan, will present "How will generative AI change scientific software?" Abstract: Across biomedical research areas, scientists make and use code to facilitate data collection, generate data through computational simulations, investigate patterns in data through descriptive statistics and visualizations, and run statistical analyses to connect data to hypotheses. This talk will give an overview of an ongoing research program about the present and future of scientific software with an emphasis on applications to biomedical research. First, we will review findings from a recently-published study of how scientists adopt new software tools for data-intensive research, which sheds light on the pressures currently facing scientists who wish to expand their data analysis toolkit. Second, we will discuss new research that will look at which researchers are using generative AI tools for programming, how researchers reason about the validity of generated code, and how scientific practices and teamwork may be changing as a result. Bio: Elle O'Brien, Ph.D. is a lecturer and research investigator at the University of Michigan. Dr. O'Brien trained at the University of Washington in computational neuroscience methods with a particular focus on the auditory nervous system. Through this work, she became interested in broad questions about how scientists develop software to collect, analyze, and share data and statistical models. Currently, Dr. O'Brien is researching how scientists navigate the use of generative AI tools for programming. This year's SHRP schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fogww.mj.am%2Flnk%2FAU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo%2F5%2FVzPUtXKo0Dowllp_TK_BrQ%2FaHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX3NjaGVkdWxl&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C5be193e13aea4c4e9e9808dc62e4db5f%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638493983124541006%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=04aNEglQmcKzvavFmWjYFrW15t0STAT2lZ%2FWTdWchQw%3D&reserved=0> Titles and abstracts of all SHRP talks are here: https://purdue.edu/TPAN/hearing/shrp_abstracts<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fogww.mj.am%2Flnk%2FAU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo%2F6%2Fa2vUEcd_J6SQbZdR8Ley5Q%2FaHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX2Fic3RyYWN0cw&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C5be193e13aea4c4e9e9808dc62e4db5f%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638493983124541006%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=zLF%2FB1qDsbOB9RpqPFSelGXAg%2Bl64NOvM1VmlmIYXKM%3D&reserved=0> Mon., April 29: BME PhD Preliminary Exam Announcement for Thejas Vishnu Ramesh (J. Rispoli and V. Rayz, advisors). Everyone is invited to attend the public presentation beginning at 2:00 PM in MJIS 2001. Research title: Conductive fabric based wearable coil for cervical spine and carotid arteries MRI at 3T. Thesis committee members: Dr. Joseph Rispoli (co-chair), Dr. Vitaliy Rayz (co-chair), Dr. Craig Goergen (committee member) and Dr. Uzay Emir (committee member). Abstract: MRI is a non-ionizing, non-invasive imaging modality that provides superior soft tissue contrast. Radiofrequency (RF) coils are the antennas through which images are obtained in MRI. Volume coils provide a homogeneous field around the region of interest (ROI) while surface coils help obtain the maximum signal-to-noise ratio (SNR) for high resolution images. Receive arrays are made of multiple surface coils for concomitant acquisition of spatial information from the anatomy, thus enabling parallel imaging. MR angiography (MRA) techniques such as time-of-flight (TOF) MRI and phase contrast (PC) angiography take advantage of parallel imaging to visualize the vasculature and understand the underlying hemodynamics that can lead to cardiovascular diseases, especially in the carotid arteries. A rigid whole neck array that contains coils that extend to the cervical spine are often used to image the carotid arteries. However, the rigid neck array lacks adaptability to varying neck sizes, thus limiting the SNR. Wearable coils that tightly conform around the anatomy of interest developed using techniques such as screen printing, conductive elastomer, and conductive thread reduce coil setup time while ensuring maximum SNR in the final image. However, current wearable coil fabrication methods require specialized manufacturing practices, which render coil development an expensive process. Therefore, a wearable array developed using commercially available conductive fabric is proposed for simultaneous bilateral carotid arteries and cervical spine imaging at 3T. The conductive fabric method eliminates specialized manufacturing needs for developing wearable coils, thus enhancing RF coil accessibility without compromising patient comfort and image quality. Zoom link: https://purdue-edu.zoom.us/j/92041421380?pwd=SGRQaVcvS3MrdEduSHdIazBSNFVkZz09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F92041421380%3Fpwd%3DSGRQaVcvS3MrdEduSHdIazBSNFVkZz09&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C5be193e13aea4c4e9e9808dc62e4db5f%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638493983124697264%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=NhsF7cd3%2BdA3qYXbZu3SBOYphPnYBI%2B7b%2B1Q5PfD9j8%3D&reserved=0> Tues., May 7: BME PhD Defense Announcement for Vidhya Vijayakrishnan Nair (Yunjie Tong, advisor). Everyone is invited to attend the public presentation beginning at 9:00 AM in MJIS 2001 and via Zoom. Research title: Human Cerebrospinal Fluid Movement across Wake and Sleep States - A Multimodal Imaging Study. Thesis Committee Members: Dr. Yunjie Tong (Chair), Dr. A.J. Schwichtenberg, Dr. Vitaliy L. Rayz, Dr. Yu-Chien Wu. Abstract: The movement of Cerebrospinal Fluid (CSF) within the brain's ventricles and the subarachnoid spaces of both the cranium and spine is crucial for the health and functioning of the central nervous system. Recent research has emphasized CSF movement's importance in metabolic waste clearance and its effect on the pathophysiology of neurodegenerative and neurodevelopmental disorders. Additionally, CSF movement is significantly enhanced during Non-rapid eye movement (NREM) sleep. Despite the critical role of CSF in maintaining brain health, a comprehensive understanding of the mechanisms driving its movement across different states of wakefulness and sleep is lacking. In this work, multimodal imaging was utilized to simultaneously monitor CSF movement and brain hemodynamics via functional Magnetic Resonance Imaging (MRI), neural activity through Electroencephalography (EEG), and non-neuronal systemic physiology via peripheral functional Near-Infrared Spectroscopy (fNIRS). Our findings reveal that CSF movement is influenced by multiple physiological forces concurrently. During wakefulness, both low-frequency vasomotion and respiration interact to regulate CSF movement. Furthermore, systemic physiological changes significantly impact CSF movement during light NREM sleep, even in the presence of autonomic neural activity. Notably, during deep NREM3 sleep, CSF movement magnitude increases independent of the magnitude of brain hemodynamics, suggesting a decrease in impedance to CSF movement and an enhanced exchange between CSF and interstitial fluid (ISF) in the brain. Building on these observations, significant enhancement of CSF movement was also achieved via simple respiratory interventions, thereby demonstrating their potential to be used as clinical protocols across pathologies characterized by reduced CSF movement. Zoom Meeting Link: https://purdue-edu.zoom.us/j/95341354792?pwd=L2ZBTmJYUEVDRXhDTm03cU9JYlBOUT09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F95341354792%3Fpwd%3DL2ZBTmJYUEVDRXhDTm03cU9JYlBOUT09&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C5be193e13aea4c4e9e9808dc62e4db5f%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638493983124697264%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=rQD4YYqKyCTBL2VNw%2FM7zjhc85Tb4Ip7VPSo7hnI8Dg%3D&reserved=0> Meeting ID: 953 4135 4792 Passcode: 741481 BME Distinguished Seminar Series, 9:30 a.m., MRGN 121 (NOTE LOCATION CHANGE) or via Zoom. Zoom link: https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F5593290378%3Fpwd%3DeFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C5be193e13aea4c4e9e9808dc62e4db5f%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638493983124697264%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=Yvdny7g9vgMb6Py2zENQZeIzF0OQduYFWM5Aj6yhIHA%3D&reserved=0> Note: Students registered for the seminar are expected to attend in-person. Week # Date Speaker Title Host Website 15 4/24/2024 Stacey Finley Nichole A. and Thuan Q. Pham Professor and Associate Professor of Biomedical Engineering, Chemical Engineering and Materials Science, and Quantitative and Computational Biology, USC Kinzer-Ursem Pienaar https://viterbi.usc.edu/directory/faculty/Finley/Stacey<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fviterbi.usc.edu%2Fdirectory%2Ffaculty%2FFinley%2FStacey&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C5be193e13aea4c4e9e9808dc62e4db5f%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638493983124697264%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=yww9zjuKeW9AkaOM1PGN%2B2fJjl8htMJhVXHzQaPI4hU%3D&reserved=0> Postdoctoral Fellow Opportunity - IUSM Emergency Medicine The laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include: (1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally. For additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Findiana.peopleadmin.com%2Fpostings%2F19651&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C5be193e13aea4c4e9e9808dc62e4db5f%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638493983124697264%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=UQhS%2BSH3PzO5AkSaFALAAnIBH5yAXlT%2Bf8WTqAp4flc%3D&reserved=0> Attachments: Grad Programs update April 2024 for faculty meeting presentation New Policy for AI use in Graduate Programs Exams and Dissertations in BME -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list