November 2024 - Bmegradstudents-list

[Bmeroundtable-list] Engineering in Medicine Symposium
by Gelfand, Johanna K 19 Nov '24

19 Nov '24

(Sent to BME faculty, staff and graduate students) This is for a neuro-focused event in Burton Morgan on 12/6. Additional information and registration are available at: https://engineering.purdue.edu/BME/AboutUs/News/allevents/2024-1206-symposi… Thanks, Craig ------------------------------------------- Craig J. Goergen, PhD (he/him/his) Leslie A. Geddes Professor Weldon School of Biomedical Engineering Purdue University 206 S. Martin Jischke Drive, Room 3025 West Lafayette, IN 47907 office: +1 (765) 494-1517 https://engineering.purdue.edu/cvirl -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME PhD Preliminary Exam Announcement for Sayeh Jalali Dowlatshahi (J. Linnes, Advisor)
by May, Sandra M 18 Nov '24

18 Nov '24

BME PhD Preliminary Exam Announcement for Sayeh Jalali Dowlatshahi (J. Linnes, Advisor) Title: Quantification and Validation of Cervical Cancer-Associated Protein Biomarkers for Point-of-Care Early Cervical Cancer Detection Date: Tuesday, December 3, 2024 Time: 10:00 am Location: MJIS 2001 / Zoom Link: https://purdue-edu.zoom.us/j/8087054178<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Thesis Committee Members: Prof. Jacqueline C. Linnes (Chair), Prof. Sulma Mohammed, Prof. Natalia Rodriguez, and Prof. Young Kim Abstract: Cervical cancer is the second most commonly diagnosed cancer in women and the second leading cause of cancer-related deaths among them globally. The incidence and mortality rates of this disease are considerably higher in low- and middle-income countries (LMICs). Current gold-standard cervical cancer screening techniques are expensive and time-consuming, possess low sensitivity or specificity, and require trained personnel and sophisticated instrumentation, limiting their implementation in low-resource settings. Therefore, a low-cost, rapid, sensitive, and specific point-of-care (POC) early-stage cervical cancer diagnostic assay is urgently needed. This research develops a complete workflow for cervical sample (1) collection and processing, (2) testing, and (3) result interpretation, for a POC cervical cancer screening test based on a paper-based lateral flow immunoassay (LFIA). Common cervical collection tools were compared to identify the one with optimal cellular recovery. Subsequently, a simplified cell lysis technique using radioimmunoprecipitation assay lysis buffer was devised for specimen processing. Four known key cervical precancer and cancer protein biomarkers were quantified in lysates of cultured cervical cells and clinical specimens using commercial enzyme-linked immunosorbent assays to assess their detection feasibility on paperfluidic platforms and obtain an estimate of their ranges, as these markers had only been studied qualitatively. The LFIA developed in this research detects topoisomerase II alpha (TOP2A), an enzyme innately involved in DNA replication that is overexpressed in cervical cancer patients. The test's colorimetric labels are 40-nm gold nanoparticles conjugated to mouse anti-TOP2A detector antibody molecules. Conjugation efficiency was evaluated through commercial quality control dipstick tests and dynamic light scattering. The chosen conjugate was then used with in-house dipstick assays to determine the control line's optimal goat anti-mouse immunoglobulin G antibody concentration. So far, the test line has detected as low as 50 ng/mL of TOP2A, showing promise that the platform will work in the 20-100-ng/mL clinical range. Upon optimization, these parameters will be incorporated into the TOP2A LFIA design. The device performance will be assessed with lysates of clinical cervical swab specimens. Furthermore, to streamline result interpretation, a machine learning (ML) classification algorithm will be developed based on the clinical samples' test line signal intensity and cytology category. This low-cost rapid test coupled with the cytology data-informed ML model will enable sensitive and specific cervical cancer screening in LMICs, leading to larger screening populations, more timely diagnosis, and earlier effective treatment, thereby significantly reducing the burden of this disease in those regions and worldwide. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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FW: Bioinformatics webinar flyer and link
by Gelfand, Johanna K 18 Nov '24

18 Nov '24

Please see below opportunity on behalf of Amelia Linnemann. Thanks! From: Kuhn, Joshua <kuhnjo(a)iu.edu<mailto:kuhnjo@iu.edu>> Sent: Thursday, November 14, 2024 12:16 PM To: Eadon, Michael T <meadon(a)iu.edu<mailto:meadon@iu.edu>>; Sutton, Timothy Alan <tsutton2(a)iu.edu<mailto:tsutton2@iu.edu>>; Sandoval Jr, Ruben M <rsandova(a)iu.edu<mailto:rsandova@iu.edu>>; Martinez Irizarry, Michelle Maria <micmart(a)iu.edu<mailto:micmart@iu.edu>>; Barwinska, Daria <dbarwins(a)iu.edu<mailto:dbarwins@iu.edu>>; Melo Ferreira, Ricardo <rimelof(a)iu.edu<mailto:rimelof@iu.edu>>; Gisch, Debora <dgisch(a)iu.edu<mailto:dgisch@iu.edu>>; Rhodes, George J <grhodes(a)iu.edu<mailto:grhodes@iu.edu>>; Dagher, Pierre C. <pdaghe2(a)iu.edu<mailto:pdaghe2@iu.edu>>; Division of Nephrology <divneph(a)iupui.edu<mailto:divneph@iupui.edu>>; IN-MDEP-NEPH-R2-201-Conference Room <IN-NEPH-R2-201(a)resource.exchange.iu.edu<mailto:IN-NEPH-R2-201@resource.exchange.iu.edu>>; Ferkowicz, Michael J. <mferkow(a)iu.edu<mailto:mferkow@iu.edu>>; Ashkar, Tarek Maurice <telachka(a)iu.edu<mailto:telachka@iu.edu>>; Gulbronson, Connor <cgulbron(a)iu.edu<mailto:cgulbron@iu.edu>> Subject: Bioinformatics webinar flyer and link https://iu.zoom.us/webinar/register/WN_3b9g7cMITEWSH0hD08ueSw#/registration<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fiu.zoom.u…> Link to register [cid:image001.png@01DB368E.F62AD620] Joshua B. Kuhn Program Management Specialist- KPMP/OBRIEN Division of Nephrology/Department of Medicine phone- 317-278-6750

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[Bmeroundtable-list] BME 3rd Year PhD Student Seminar Series: Friday 11-22
by Rowen, Elizabeth Pearl 18 Nov '24

18 Nov '24

[cid:image001.jpg@01DB05C3.B4BD0650] BME 3rd Year Seminar Series Friday, November 22nd, 2024 1:30 - 2:30 PM EST MJIS 1001 Evaluation links: Shen Chang: https://purdue.ca1.qualtrics.com/jfe/form/SV_af6g9cIoztLdgeq<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Shahriar Zeynali: https://purdue.ca1.qualtrics.com/jfe/form/SV_0vVmSMn7xBjuebA<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Evaluation surveys should only be completed after the seminar has taken place, and only by those who attended the seminar. We appreciate those who are able to attend and provide feedback; These surveys will help us determine the recipient of the 2024 Fearnot Prize for the best presentation! Advancing Human Situational Awareness Assessment in Medical Intervention Shen Chang (Nan Kong/Renran Tian, advisors) [cid:image002.png@01DB3996.3E4A3590] Abstract: Situational awareness (SA) is a critical cognitive process that fundamentally shapes human performance in complex environments. A significant challenge exists in accurately measuring and evaluating SA, particularly in scenarios where untrained individuals must interact with advanced technologies during critical situations. Our initial research demonstrated this through analysis of human-drone interactions (HDI) in simulated emergency medical responses, where we developed an AI framework leveraging computer vision and graph embeddings to capture spatial-temporal relationships between humans, drones, and their environment. This work revealed both the power and limitations of behavior-based SA measures. Building upon these insights, we propose extending our framework through evidential learning techniques, using the NurViD dataset of nursing procedures as a validation domain. By modeling expert behavior patterns and their associated uncertainties, our proposed approach aims to quantify both the inherent variability in task execution and knowledge gaps in performance. This uncertainty-aware framework would enable objective comparison between expert and novice performance, providing a more standardized method for SA assessment. The implications of this research extend far beyond theoretical advancement-real-time SA assessment could enable adaptive coaching systems that dynamically respond to individual performance levels, transforming how we approach emergency response training and healthcare delivery. By bridging the gap between novice and expert performance through intelligent assessment and feedback, our work aims to enhance the safety and effectiveness of human-technology interactions in life-critical situations, potentially saving lives through improved emergency response capabilities and healthcare outcomes. T1 sensitivity to ferumoxytol at 3T versus 0.55T field strengths Shahriar Zeynali (Behzad Sharif/Craig Goergen, advisors) [cid:image005.jpg@01DB3996.3E4A3590] Abstract: Ferumoxytol-enhanced cardiac MRI (FE CMRI) has the potential to detect myocardial ischemia by enabling accurate assessment of changes in intra-myocardial blood volume (MBV). However, in-vivo comparison of ferumoxytol behavior at different field strengths is lacking. We analyzed and compared (a) relative myocardial and blood T1 changes in response to a range of ferumoxytol doses, (b) artifact severity on MOLLI T1 maps, in a relatively large cohort of animal studies at 0.55T and 3T. FE CMRI at 0.55T demonstrated 2.5-fold greater myocardial T1 sensitivity to ferumoxytol dose compared to 3T, with significantly reduced susceptibility image artifacts. The observed increase in ferumoxytol sensitivity at 0.55T enables dose reduction while maintaining diagnostic quality, offering a more cost-effective platform for FE CMRI. This could particularly benefit stress/rest T1 reactivity mapping where detecting subtle MBV changes is crucial. Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME Distinguished Research Seminar - Wed., Nov. 20
by Gelfand, Johanna K 18 Nov '24

18 Nov '24

[cid:image001.png@01DB3992.CF8DB260] BME DISTINGUISHED RESEARCH SEMINAR SERIES Wednesday, November 20, 2024 9:30 - 10:20am, MJIS 1001 and via ZOOM ZOOM LINK: https://purdue-edu.zoom.us/j/93455052114<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> *Note: Students registered for the seminar are expected to attend in-person. "3D Printing to Engineer Complex Tissues" [cid:image002.png@01DB3992.CF8DB260] John Fisher, Ph.D. Distinguished University Professor & Department Chair Fischell Department of Bioengineering University of Maryland, College Park Abstract: Generating complex tissues has been an increasing focus in tissue engineering and regenerative medicine. With recent advances in bioprinting technology, our laboratory has focused on developing platforms for treating and understanding clinically relevant problems ranging from congenital heart disease to orthopedic trauma. In this presentation, we focus on engineering both orthopedic and gynecological tissues. We utilize digital light processing (DLP)-based and extrusion-based additive manufacturing to generate engineered tissues. Both approaches begin with CAD models that are then transferred to printing platforms. Prints use a variety of inks, including synthetic (PEG) and natural (GelMA, ECM) materials. Evaluation of printed constructs assesses critical criteria, including print fidelity, material properties (immediately after printing and at longer time points), cell viability, and cell functionality. Tissue function is assessed both in vitro and in vivo. This presentation will cover the diverse range of materials and processes developed in our laboratory and their application to relevant, emerging problems in tissue engineering. Biography: Dr. John P. Fisher is a Distinguished University Professor, MPower Professor, Distinguished-Scholar Teacher, Fischell Family Distinguished Professor, and Department Chair in the Fischell Department of Bioengineering at the University of Maryland. Dr. Fisher is also the Director of the Center for Engineering Complex Tissue (CECT), which aims to create a broad community focusing on 3D printing and bioprinting for regenerative medicine applications. As the Director of the Tissue Engineering and Biomaterials Laboratory, Dr. Fisher's group investigates biomaterials, stem cells, bioprinting, and bioreactors for regenerating lost tissues, particularly bone, cartilage, and cardiovascular tissues. Dr. Fisher has been elected Fellow of the American Institute for Medical and Biological Engineering (2012), the Biomedical Engineering Society (2016), the International Academy of Medical and Biological Engineering (2020), and the International Union of Societies for Biomaterials Science and Engineering (2024). Dr. Fisher is currently the Editor-in-Chief of the journal Tissue Engineering. ~ BME Host: Taimoor H. Qazi ~ Jo Gelfand Intra/Extramural Relations Administrator Purdue University Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 765-494-2996 jo(a)purdue.edu<mailto:jo@purdue.edu> [cid:image003.jpg@01DB3992.CF8DB260] -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME PhD Preliminary Exam Announcement for Om Kolhe (K. Jayant, advisor)
by May, Sandra M 15 Nov '24

15 Nov '24

BME PhD Preliminary Exam Announcement for Om Kolhe (K. Jayant, advisor) Everyone is invited to attend the public presentation beginning at 1:30 PM. TITLE: INVESTIGATING LOCAL RECURRENT CIRCUIT MOTIFS DURING MOTOR DECISION MAKING DATE: November 22, 2024 TIME: 1:30 PM LOCATION: MRGN 129 COMMITTEE MEMBERS: Dr. Krishna Jayant (Primary Advisor) Dr. Edward Bartlett Dr. Kevin Otto Dr. Scott Pluta Dr. Saeed Mohammadi ABSTRACT: Working memory is a fundamental feature in goal-directed decision-making, requiring both online maintenance and volitional manipulation of stored information. A number of studies have shown that the secondary motor cortex (M2), a pre-motor region in the prefrontal cortex, is a major hub for storing working memory. The prevailing view of M2 is that superficial layers L2/3 store working memory representations, evidenced by ramping of neural activity. However, it remains unclear if and how layer 5 contributes to this dynamical interaction. Our hypothesis is that stored information in L2/3 is modulated by deep layer 5 (L5) in a top-down fashion to extract task-relevant information. In this study, I aim to investigate how L5 enables efficient representation and manipulation of working memory in L2/3 through the emergence of neural ensembles in M2. I posit that L5 gates and spatiotemporally filters the information stored in L2/3 through propagating electrical activity known as traveling waves, allowing for the emergence of stable neural ensembles during working memory. Additionally, I postulate that reward reinforcement through dopaminergic inputs to this recurrent L2/3-L5 circuit selectively enhances task-relevant activity, thus increasing the dynamic range of M2. My research comprises two aims: investigating how TWs in the local recurrent circuit enable the emergence of stable neural ensembles (Aim 1) and examining dopamine's role in the maintenance of stable representations (Aim 2). To test these hypotheses, I have designed a novel recording platform combining high-resolution electrical recording in 3D volumes of brain tissue, two-photon imaging in head-fixed behaving mice, and electrochemical recordings of released neurotransmitters like dopamine. Successful completion of these aims will provide new insights into how local recurrent circuits store and compute information, and the role of dopamine in these processes. The outcomes will improve our understanding of cognitive processes like working memory and selective attention while potentially informing the design of large language transformer network models. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME PhD Defense Announcement for YunWen (Darren) Chu (S. Pluta and K. Jayant, co-advisors)
by May, Sandra M 14 Nov '24

14 Nov '24

BME PhD Defense Announcement for YunWen (Darren) Chu (S. Pluta and K. Jayant, co-advisors) Everyone is invited to attend the public presentation beginning at 9:00am. Title: Neural mechanism for tactile stimuli selection Date: Nov 19th (Tue) Time: 9:00am Location: MJIS 2001 and Zoom: https://purdue-edu.zoom.us/j/6550883679?pwd=d014cm1EL1BrUzFzN2VWWlYrQmtDdz0…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Committee members: Dr. Scott R. Pluta, co-chair Department of Biological Sciences Dr. Krishna Jayant, co-chair Weldon School of Biomedical Engineering Dr. Maria C. Dadarlat Makin Weldon School of Biomedical Engineering Dr. Michael G. Heinz Weldon School of Biomedical Engineering Abstract : The ability to selectively respond to a desirable stimulus while ignoring the surroundings is essential for efficient decision making, such as sensing food amongst rocks. This requires accurate discrimination of the input features and their associated values. Current understanding of value-modulated sensory processing is highly biased towards the visual modality, and little is known about how tactile signals evolve across cortical and subcortical regions in the same goal directed task. It is also unclear whether task engagement and action outcome modulates neural representation of the sensory and value space. To answer these questions, we investigated the mouse primary somatosensory cortex (S1) and the superior colliculus (SC) while the animal was performing an active spatial discrimination task. The mice were trained to actively touch and associate a whisker-dependent stimulus with reward (GO whisker) while ignoring tactile input to the adjacent whisker (NoGo whisker). We hypothesize that sensory information in the S1 neocortex is encoded in the form of physical features such as location, which is then converted into a map of stimulus value in the SC. We found that both S1 and SC neurons accurately discriminated between adjacent whisker stimuli with the SC displaying a much stronger preference than S1 for the higher valued stimulus. This bias was unique to SC wherein spiking activities were facilitated for the rewarded stimulus and suppressed for the negative stimulus. Importantly, removing the opportunity for positive stimulus selection reduced but did not abolish positive bias in the SC, reinforcing its role in value-based sensory modulation. Moreover, the spontaneous activity in SC but not S1 predicted response latency and performance accuracy. Taken together, this study demonstrated a transformation of stimulus priority from a somatotopic map in S1 to a value map in SC. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME 3rd Year PhD Seminar Series: Friday 11-15
by Rowen, Elizabeth Pearl 14 Nov '24

14 Nov '24

[cid:image001.jpg@01DB05C3.B4BD0650] BME 3rd Year Seminar Series Friday, November 15th, 2024 1:30 - 2:30 PM EST MJIS 1001 Evaluation links: Adam Wright: https://purdue.ca1.qualtrics.com/jfe/form/SV_5oHr7tCH1pYgxNA<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Tuba Marjan: https://purdue.ca1.qualtrics.com/jfe/form/SV_6wZA650L4jCMzIO<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Evaluation surveys should only be completed after the seminar has taken place, and only by those who attended the seminar. We appreciate those who are able to attend and provide feedback; These surveys will help us determine the recipient of the 2024 Fearnot Prize for the best presentation! Magnetic resonance imaging tools to navigate the path from healthy brain aging to brain dysfunction Adam Wright (Qiuting Wen/Yunjie Tong, advisors) [cid:image003.png@01DB3427.B5402390] Abstract: The brain is a remarkable organ, constantly engaged in maintenance and remodeling to support our everyday thoughts, actions, and experiences. However, the brain doesn't always function perfectly. A delicate balance exists between age-related declines in brain function and dysfunction that lead to disease. To navigate this complexity, it's essential to understand what constitutes healthy aging, enabling us to better identify and interpret the disruptions associated with neurological diseases. In our research, we leverage magnetic resonance imaging's (MRI) sensitivity to diverse physiological processes-such as cardiac pulsations, respiration, and slow vessel motion-to non-invasively study various aspects of human brain health. We have developed tools to study waste clearance, cerebrovascular health, and cerebral circulation. With advanced aging, we have observed changes across these processes, including waste clearance dysfunction, reduced vascular compliance, and increased cerebral blood circulation times. Our improved understanding of healthy, age-related changes in brain function will ultimately guide future research on brain dysfunction in neurological and neurodegenerative conditions. Constructing a decellularized extracellular matrix containing interpenetrating network hydrogel to probe cell-material interactions Tuba Marjan (Taimoor Qazi, advisor) [cid:image006.jpg@01DB3427.B5402390] Abstract: Synthetic biomaterial scaffolds are commonly used in vitro to study cell behavior, but they often lack the native biochemical cues essential for guiding cellular responses. Decellularized extracellular matrices (dECMs) offer bioactivity but generally lack the mechanical stability needed for long-term cell culture. To address this, we developed an interpenetrating network (IPN) by integrating dECM into a synthetic, photo-crosslinkable hydrogel based on Norbornene-modified hyaluronic acid (Nor-HA). Porcine skeletal muscle tissue was first decellularized, and varying concentrations of dECM were incorporated into the Nor-HA hydrogels. Rheological tests showed that adding dECM at 2.5 mg/mL increased the storage modulus of the IPN hydrogel from ~500 Pa to ~1200 Pa. However, higher dECM concentrations (5 & 10 mg/mL) led to a significant decrease in mechanical strength, likely due to inhibited crosslinking. Hydrogel cryosections stained with Picrosirius red showed uneven dECM distribution potentially caused by dECM particle aggregation. Cell adhesion studies using NIH 3T3 fibroblasts showed that cells had the greatest spreading area on IPNs containing 2.5 mg/mL dECM corresponding to the highest observed mechanical modulus. In contrast, IPNs with higher dECM concentrations and lower mechanical moduli showed reduced cell spreading. Future studies will look into controlling mechanical properties across all groups to isolate the biochemical effects of dECM on cell behavior. Overall, this IPN platform provides a photo-crosslinkable, bioactive scaffold to explore cell-matrix interactions which may help us understand wound healing better in various tissue and disease contexts. Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Machine Learning Hackathon Event
by Siemers, Tammy R 14 Nov '24

14 Nov '24

Please see attached for a Machine Learning Hackathon Event that is taking place on campus. Registration: https://docs.google.com/forms/d/e/1FAIpQLSfjljIEVIEx_42OJkc3qYlGAfQZT7kwuun…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.goog…> Tammy

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[Bmeroundtable-list] End of semester reminder
by Gelfand, Johanna K 14 Nov '24

14 Nov '24

Just a reminder: If you need to spray paint something, PLEASE put down some newspaper or a tarp.... And move away from the building. Since the Grounds crew has already done their final mow of the season, we will not be able to repair this area until Spring. [cid:image001.jpg@01DB366B.D2158D70] Jo Gelfand Intra/Extramural Relations Administrator Purdue University Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 765-494-2996 jo(a)purdue.edu<mailto:jo@purdue.edu> [cid:image002.jpg@01DB366B.D2158D70] -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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