November 2024 - Bmegradstudents-list

Weldon Graduate Program Announcements November 13th, 2024
by Siemers, Tammy R 13 Nov '24

13 Nov '24

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements November 13th, 2024 * Career and Internship Opportunities * McClintock Bioscience Postdoctoral Fellowship - Apply Now! * New Course: Teaching Engineering Online * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Master's and PhD Internships, Summer 2025, Regeneron<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Manufacturing Intern, Intuitive<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Research Intern, Biomedical AI for Precision Health, Microsoft<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Biomedical Research Clinical Affairs Intern, Beckman Coulter<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> Postdoctoral Positions * NPA Website: https://careers.nationalpostdoc.org/jobs/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.n…> Full Time Positions * Field Clinical Engineer, Orchestra Biomed<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Quality Engineer/Biomedical Engineer, International Biomedical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * R&D Engineer II, Olympus Corporation<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Biomedical Engineer/Clinical Engineer, AgileRank<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Sr. R&D Engineer, Route 92 Medical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Engineer I, Process Development, Acera Surgical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * R&D Engineer, Expanse Medical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Purdue Start-up Job Board<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurduefou…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.a…>-Association for Clinical and Translational Science * Academic Careers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Facademicc…> * Doc Jobs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.docjo…>-Jobs beyond traditional clinical and academic roles McClintock Bioscience Postdoctoral Fellowship - Apply Now! See attached The Sandia Barbara McClintock Distinguished Postdoctoral Fellowship has been established in honor of Nobel-Prize winner, Barbara McClintock. McClintock's pioneering work in maize demonstrated that genes are responsible for turning physical characteristics on and off and her theories explained the suppression and expression of genetic information from one generation to the next. The McClintock Postdoctoral Fellow will spend half of their time on their own original, self-directed research (funded by LDRD) and half of their time on an established Sandia research project. Apply Here - Deadline to Apply is January 2nd, 2025<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcg.sandia…> New Course: Teaching Engineering Online This course is designed for anyone who wants to be prepared to teach engineering or other technical topics online. The course has three modules. The first module introduces five important features of an online course: effective course content design, methods for keeping students engaged, use of the course platform and interactive materials, accessibility of course materials, and assessment of student learning and of the instructional unit itself. In Module Two, each student will design a short instructional unit on a topic of their choice that could be included in what would typically be a "lecture" course for an audience that the student expects to teach. Each week, students will receive guidance on incorporating one of the five features discussed in Module One into their unit. Module Three is similar to Module Two, but students will prepare an instructional unit that could be incorporated into a "laboratory" course. Course Information Course number: ENE 59500-002 CRN: 31996 Meeting Time: Thursdays, 10:30 a.m. - 1:20 p.m. Location: ARMS 3109 Instructor: Audeen Fentiman Online asynchronous section (ENE 59500-003, CRN 31998) is available for students registered on campus but unable to attend the face-to-face section. Contact the instructor for additional information: fentiman(a)purdue.edu<mailto:fentiman@purdue.edu> Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. Nov. 13th Business Databases: Ace Your Job Interview, Find Investors for Your Research Idea (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 14th Business Meal Etiquette (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 14th Conference Paper Writing and Presenting: Strategies for Success (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 15th RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 15th Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 18th Becoming a Resilient Scientist: Unit 5 - Managing Up to Maximize Mentoring Relationships (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>) Nov. 18th Managing Uncertainty During Graduate School (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 19th Debt Management (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 2nd F31/F30 Workshop Series Topic 3: "Research Strategy--Significance & Motivation" Presentation (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 6th Postdoc Power Session: First Friday in December (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 13th Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 16th F31/F30 Workshop Series Topic 3: "Research Strategy--Significance & Motivation" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 2nd Deadline to Apply for McClintock Bioscience Postdoctoral Fellowship (Apply Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcg.sandia…>) Jan. 13th F31/F30 Workshop Series Topic 4: "Research Strategy Approach" Presentation (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 27th F31/F30 Workshop Series Topic 4: "Research Strategy Approach" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 31st Application deadline for Johnson & Johnson Japan Smart Healthy Aging QuickFire Challenge (Apply<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjnjinnova…>) Feb. 10th F31/F30 Workshop Series Topic 5: "Biosketch and Other Documents" Working Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 25th 4th Annual Grad WiE Network Symposium (WiE<https://www.purdue.edu/wiep/CurrentStudents/Graduate%20Women%20in%20Enginee…>) News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education BME Students (ONLY): Schedule appointments with me via BoilerConnect here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>. Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [cid:image002.png@01DB35ED.03D84CF0]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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BME PhD Preliminary Exam Announcement for Madhurima Patra (M. Heinz, advisor)
by May, Sandra M 12 Nov '24

12 Nov '24

BME PhD Preliminary Exam Announcement for Madhurima Patra (M. Heinz, advisor) Everyone is invited to attend the public presentation beginning at 2:30 pm. Research title: Neural Correlates of Spectro-Temporal Modulation Detection : Insight from Cross-Species EEG Studies Date: November 20, 2024 Time: 2:30 pm Location: LYLE 1150 and Zoom: https://purdue-edu.zoom.us/my/mheinz.purdue<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Committee members: Michael Heinz ( Chair), Edward Bartlett, Anne Sereno, Hari Bharadwaj Abstract: Individuals with sensorineural hearing loss often struggle to understand speech in noisy environments despite communicating well in quiet settings. Natural sounds exhibit complex spectro-temporal variations in intensity across time and frequency domains. Selective tuning to these Spectro-Temporal Modulations (STMs) is crucial for understanding naturalistic sounds and speech intelligibility in noise. Recent studies suggest that STM stimuli can be good non-language predictors of speech-in-noise intelligibility, forming the basis for a commercial clinical test. However, the underlying mechanisms remain unknown. Our work uses STM stimuli with dynamically modified parameters to study behavioral and electroencephalographic (EEG) signatures responsible for perceptual differences across populations. To gain mechanistic insights, chinchillas are invaluable pre-clinical animal models for exploring auditory functions under controlled hearing-loss conditions. A recently developed multi-channel mini-EEG cap for lightly sedated chinchillas enables reliable cortical response acquisition. Preliminary results indicates that cortical responses reflect STM structure changes in humans and chinchillas. Response magnitude increases with modulation depth, primarily reflected in low-frequency neural oscillations. With increasing signal-to-noise ratio, responses become less scattered and show reduced coherence across channels throughout the cortical topology, concentrating on the contralateral side. This cross-species approach allows direct comparison of analogous responses on a perceptual level, enhancing translational potential. It demonstrates how changes in STM structure are reflected in neural signatures of both species, providing a comprehensive understanding of auditory processing mechanisms across humans and chinchillas. This research is particularly important for aging populations and hearing-aid recipients, as it explores the limitations of missing perceptual information and its impact on speech intelligibility in noisy environments.

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[Bmeroundtable-list] BME Distinguished Research Seminar - Wed., Nov. 13
by Gelfand, Johanna K 12 Nov '24

12 Nov '24

[A close up of a sign Description automatically generated] BME DISTINGUISHED RESEARCH SEMINAR SERIES November 13, 2024 9:30-10:20 am, MJIS 1001 and via ZOOM ZOOM LINK: https://us02web.zoom.us/j/89909212164?pwd=twxyjdZX8IIU3sglvspbepJ8FSZ0NC.1<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fus02web.z…> *Note: Students enrolled in the seminar course are expected to attend in person. “Ultra‐high resolution structural and molecular imaging of cells and tissues” [A person in a red shirt Description automatically generated] Fang Huang Reilly Associate Professor of Biomedical Engineering, Purdue University Abstract: Since Robert Hooke’s first description of a cell in Micrographia 350 years ago, microscopy has played an important role in understanding the rules of life. Far-field fluorescence microscopy is a powerful approach in biological and biomedical research due to its live cell compatibility and molecular specificity. A major hurdle over the last century has been the limited resolution due to the diffraction of light. Super-resolution microscopy methods, such as single-molecule localization microscopy, overcome this fundamental barrier to improve the resolution limit (250-600 nm, lateral-axial) down to a few nanometers. The development and application of SMLM majorly focus on fixed cells in thin samples and cellular structures that lie on/close to the coverslip surface and therefore, the profound impact of SMLM on biophysical, medical, and biological research has yet to fully unfold. Dr. Huang will discuss some of his team’s most recent projects which explore newly available sensors/devices such as high-speed sensors and deformable mirrors, analytical methods such as deep learning, and novel optical instrumentation to allow SMLM imaging in live cells and tissue specimens. He will show the capabilities of these new imaging systems in revealing the fine details of subcellular structures from a diverse set of biological systems including viruses, bacteria, yeasts, mammalian cells, and brain sections. Bio: The Huang lab focuses on developing novel optical imaging capacities to make significant advances in defining the structure and function of cellular constituents in biological systems. Through single molecule detection and localization, the lab develops novel super-resolution instruments, single molecule analytical methods and AI driven systems to push the envelope of spatial and temporal observation limit of biomedical research. The team demonstrate their innovative imaging systems, algorithms and computation platforms across a diverse range of biological model organisms including phages, viruses, bacteria, yeasts, mammalian cell cultures, tissues, and most recently embryos. The lab establishes and maintains strong collaborations with cell and developmental biologists, biophysicists, neuroscientists, and chemists to tackle fundamental biomedical questions in areas such as cytokinesis, epigenetics, neural circuits, immunology, and cell motility. Through these collaborations, the research team generates broad impacts to reveal disease mechanisms in Alzheimer's, autism, addiction, and cancer, and advance drug development. ~ BME Host: Krishna Jayant~ -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME Master's Defense Announcement for Martina Dalolio (R. Shi, advisor)
by May, Sandra M 11 Nov '24

11 Nov '24

BME Master's Defense Announcement for Martina Dalolio (R. Shi, advisor) Everyone is invited to attend the public presentation beginning at 12:00pm. Title: "Characterization of Sleep Spindles Using a Novel Automated Detection Algorithm: Links to Sleep Patterns and Seizure Susceptibility in a Repetitive Blast-Induced Traumatic Brain Injury Mouse Model" Date: November 22, 2024 Time: 12:00pm Location: MJIS 2001 Committee members: Riyi Shi, Chair; Adam J. Kimbrough; Matthew P. Ward Abstract: Blast-induced traumatic brain injury (bTBI) accounts for one-third of traumatic brain injuries in soldiers, with chronic effects largely unknown. Electroencephalogram (EEG) signal changes may help predict outcomes like sleep disorders and post-traumatic epilepsy (PTE), which have been reported in rodent bTBI models. Modification of sleep spindles (SSPs), crucial thalamus-cortical signal for sleep transitions, have been linked to PTE and sleep disorders in non-blast TBI, but variability in detection methods affects findings. This study uses an improved SSPs detection algorithm to aim a more rigorous analysis of SSPs characteristics, necessary to understand the sleep disorders and seizure risk 1-month post-bTBI in mice. Following either bTBI or sham (non-blast) treatment, mice underwent a 1-week video-EEG recording, with pentylenetetrazol (PTZ) administered at the end to assess seizure susceptibility. Increased NREM sleep during dark period (hypersomnia) was observed on the first day of recording and a slight reduction in REM sleep was present over the week in both groups, anticipated in bTBI compared to sham. Seizure susceptibility showed no group difference. SSPs density did not differ, but bTBI showed a reduction of SSPs in higher amplitude and frequency range compared to sham. A specific SSP profile correlated with increased seizure susceptibility, though not with REM reduction nor bTBI itself, was identified. In conclusion, video-EEG recording may induce stress, shown by REM reduction in both groups. bTBI appears to increase fragility to stress, likely due to SSPs alterations, both under acute (e.g., first day in new housing) and chronic stress, manifesting as hypersomnia and earlier REM reduction respectively. EEG electrode implantation surgery might also contribute to increased seizure susceptibility. Although the SSP profile is more associated with seizure susceptibility than with bTBI itself, SSP distribution remains altered in bTBI compared to sham reflecting a possible modification of thalamo-cortical connectivity. Further research is needed to confirm SSPs alterations' origins in bTBI. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME 3rd Year PhD Seminar Series: Friday 11-15
by Rowen, Elizabeth Pearl 11 Nov '24

11 Nov '24

[cid:image001.jpg@01DB05C3.B4BD0650] BME 3rd Year Seminar Series Friday, November 15th, 2024 1:30 - 2:30 PM EST MJIS 1001 Evaluation links: Adam Wright: https://purdue.ca1.qualtrics.com/jfe/form/SV_5oHr7tCH1pYgxNA<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Tuba Marjan: https://purdue.ca1.qualtrics.com/jfe/form/SV_6wZA650L4jCMzIO<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Evaluation surveys should only be completed after the seminar has taken place, and only by those who attended the seminar. Magnetic resonance imaging tools to navigate the path from healthy brain aging to brain dysfunction Adam Wright (Qiuting Wen/Yunjie Tong, advisors) [cid:image003.png@01DB3427.B5402390] Abstract: The brain is a remarkable organ, constantly engaged in maintenance and remodeling to support our everyday thoughts, actions, and experiences. However, the brain doesn't always function perfectly. A delicate balance exists between age-related declines in brain function and dysfunction that lead to disease. To navigate this complexity, it's essential to understand what constitutes healthy aging, enabling us to better identify and interpret the disruptions associated with neurological diseases. In our research, we leverage magnetic resonance imaging's (MRI) sensitivity to diverse physiological processes-such as cardiac pulsations, respiration, and slow vessel motion-to non-invasively study various aspects of human brain health. We have developed tools to study waste clearance, cerebrovascular health, and cerebral circulation. With advanced aging, we have observed changes across these processes, including waste clearance dysfunction, reduced vascular compliance, and increased cerebral blood circulation times. Our improved understanding of healthy, age-related changes in brain function will ultimately guide future research on brain dysfunction in neurological and neurodegenerative conditions. Constructing a decellularized extracellular matrix containing interpenetrating network hydrogel to probe cell-material interactions Tuba Marjan (Taimoor Qazi, advisor) [cid:image006.jpg@01DB3427.B5402390] Abstract: Synthetic biomaterial scaffolds are commonly used in vitro to study cell behavior, but they often lack the native biochemical cues essential for guiding cellular responses. Decellularized extracellular matrices (dECMs) offer bioactivity but generally lack the mechanical stability needed for long-term cell culture. To address this, we developed an interpenetrating network (IPN) by integrating dECM into a synthetic, photo-crosslinkable hydrogel based on Norbornene-modified hyaluronic acid (Nor-HA). Porcine skeletal muscle tissue was first decellularized, and varying concentrations of dECM were incorporated into the Nor-HA hydrogels. Rheological tests showed that adding dECM at 2.5 mg/mL increased the storage modulus of the IPN hydrogel from ~500 Pa to ~1200 Pa. However, higher dECM concentrations (5 & 10 mg/mL) led to a significant decrease in mechanical strength, likely due to inhibited crosslinking. Hydrogel cryosections stained with Picrosirius red showed uneven dECM distribution potentially caused by dECM particle aggregation. Cell adhesion studies using NIH 3T3 fibroblasts showed that cells had the greatest spreading area on IPNs containing 2.5 mg/mL dECM corresponding to the highest observed mechanical modulus. In contrast, IPNs with higher dECM concentrations and lower mechanical moduli showed reduced cell spreading. Future studies will look into controlling mechanical properties across all groups to isolate the biochemical effects of dECM on cell behavior. Overall, this IPN platform provides a photo-crosslinkable, bioactive scaffold to explore cell-matrix interactions which may help us understand wound healing better in various tissue and disease contexts. Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Watch Party invite
by Gelfand, Johanna K 07 Nov '24

07 Nov '24

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[Bmeroundtable-list] BME 3rd Year PhD Seminar Series: Friday 11-8
by Rowen, Elizabeth Pearl 07 Nov '24

07 Nov '24

[cid:image001.jpg@01DB05C3.B4BD0650] BME 3rd Year Seminar Series Friday, November 8th, 2024 1:30 - 2:30 PM EST MJIS 1001 Evaluation links: Alexander Donabedian: https://purdue.ca1.qualtrics.com/jfe/form/SV_8kPRBEQ9RLT9WXI<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Jee Hyun Park: https://purdue.ca1.qualtrics.com/jfe/form/SV_24T8XAvaQCb4fqe<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> Evaluation surveys should only be completed after the seminar has taken place, and only by those who attended the seminar. We appreciate those who are able to attend and provide feedback; These surveys will help us determine the recipient of the 2024 Fearnot Prize for the best presentation! Sensitivity of Finite Element Models to Relationship Between T2 Relaxation and Modulus in Articular Cartilage Alex Donabedian (Deva Chan, advisor) [cid:image005.png@01DB2E97.82B71EA0] Abstract: Osteoarthritis (OA) is a disabling joint disease that continues to prevail among the US population. Without a true noninvasive cure, total joint replacement surgery is a likely outcome that is costly for the healthcare system and individual. To shift treatment towards prevention and away from palliation, computational models can be a tool to study articular cartilage at risk of degradation, a hallmark sign of OA progression, before reaching severe disease states. Due to the complex microstructure of articular cartilage, generalized models cannot reliably provide subject-specific information about the underlying tissue. Finite element (FE) models can be tailored to the patient with magnetic resonance imaging (MRI) providing an individualized risk assessment. MRI-informed models exist today; however, very few of them address the spatially varying properties of articular cartilage hindering their accuracy. Here, we use MRI to inform an FE model of articular cartilage where the stiffness varies spatially. We employ an established linear relationship between MRI T2 relaxation and the dynamic modulus of articular cartilage to inform the stiffness of each element within our model. Due to the inter- and intra-material variability of cartilage, we alter this relationship by (1) shifting the dynamic modulus range while maintaining the same slope relationship to T2 and (2) altering the slope relationship to assess the change in the computed outputs. Additionally, computed areas of high stress and strain will be compared with regional cartilage health data to assess the model's potential to predict regional degradation. Tailoring the model's material properties to the patient suggests an improved individual risk assessment of developing OA compared to generalized models. APOE4 Mouse to Human Alzheimer's Disease Translational Modeling Reveals Therapeutic Perturbagen Signature Associations Jee Hyun Park (Douglas Brubaker, advisor) [cid:image002.jpg@01DB2E97.E0F65120] Abstract: Alzheimer's Disease (AD) impacts the brain by hindering behavior and cognitive function. Coupled with tau tangles and amyloid plaque, increased synapse and neuron death are features in AD patients. Numerous aspects, such as age and genetics, specifically apolipoprotein E e4 (APOE4), increase susceptibility to AD development. APOE is a carrier of lipids in the brain. There is a heightened risk of AD by expressing the APOE e4 allele due to increased levels of plaque aggregates compared to e3 carriers with dysfunctional lipid metabolism. However, how APOE4 aggravates AD has not been fully characterized. In addition, insufficient effective human therapies from mice studies and drug screenings are a challenge due to models not fully encompassing AD pathology. Thus, we used a cross-species translational model by integrating APOE4 knock-in mouse and human gene expression with demographic and clinical factors to predict human AD states. Our model determined axon guidance downregulation in AD and inflammatory pathways upregulated in AD. We also performed a Spearman correlation to identify gene signatures of drugs that resemble or reverse AD features based on mouse principal components predictive of AD. We discovered drugs used for diabetes treatment to resemble the control signatures. Our study revealed biological mechanisms dysregulated by APOE4 in mice that could be potential therapeutic targets for treating AD in humans. Future work will validate results with human datasets carrying the APOE4 allele. Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Weldon Graduate Program Announcements November 6th, 2024
by Siemers, Tammy R 07 Nov '24

07 Nov '24

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements November 6th, 2024 * Career and Internship Opportunities * Coming in Spring 2025: Deep Learning * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Engineering Intern, Biomedical Engineering, Intuitive<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Regeneron 2025 Intern, Biomedical Engineering<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Intern, Graduate, Kaiser Permanente<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.kaise…> * IAM Intern, Data Science, LabCorp<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> Postdoctoral Positions * NPA Website: https://careers.nationalpostdoc.org/jobs/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.n…> Full Time Positions * Laser Engineer, Sightpath Medical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Research and Development Engineer I, Cook Group<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Complaints Specialist, DEKA<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Design Quality Engineer, LSI Solutions<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Clinical Engineer, InterMed<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Purdue Start-up Job Board<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurduefou…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.a…>-Association for Clinical and Translational Science * Academic Careers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Facademicc…> * Doc Jobs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.docjo…>-Jobs beyond traditional clinical and academic roles Coming in Spring 2025: Deep Learning See attached Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. Nov. 6th AI Tools for Literature Review (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 6th Networking (including LinkedIn): Small Talk, Big Opportunity (CCO<https://www.cco.purdue.edu/Calendar/Event/518>) Nov. 6th Wisconsin Postdoc Expo: Free & Virtual Event (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwipostdoc…>) Nov. 7th Healthy Eating on the Run (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 8th LinkedIn (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 11th F31/F30 Workshop Series Topic 2: "Background, Training Goals, & Mentoring" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 12th Healthy Eating on the Run (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 12th Preparing to Buy a Car (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 12th Becoming a Resilient Scientist Discussion Group for Unit 4 Nov. 12th Deadline to submit Letter of Intent (LOI) for NIH DiabDocs Program (Submit Here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fredcap.st…>) Nov. 12th The Transition from Grad Student to Postdoc Virtual Presentation (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Ftennessee…>) Nov. 13th Business Databases: Ace Your Job Interview, Find Investors for Your Research Idea (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 14th Business Meal Etiquette (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 14th Conference Paper Writing and Presenting: Strategies for Success (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 15th RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 15th Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 18th Becoming a Resilient Scientist: Unit 5 - Managing Up to Maximize Mentoring Relationships (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.train…>) Nov. 18th Managing Uncertainty During Graduate School (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Nov. 19th Debt Management (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 2nd F31/F30 Workshop Series Topic 3: "Research Strategy--Significance & Motivation" Presentation (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 6th Postdoc Power Session: First Friday in December (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 13th Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Dec. 16th F31/F30 Workshop Series Topic 3: "Research Strategy--Significance & Motivation" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 13th F31/F30 Workshop Series Topic 4: "Research Strategy Approach" Presentation (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 27th F31/F30 Workshop Series Topic 4: "Research Strategy Approach" Q&A Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Jan. 31st Application deadline for Johnson & Johnson Japan Smart Healthy Aging QuickFire Challenge (Apply<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fjnjinnova…>) Feb. 10th F31/F30 Workshop Series Topic 5: "Biosketch and Other Documents" Working Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Feb. 25th 4th Annual Grad WiE Network Symposium (WiE<https://www.purdue.edu/wiep/CurrentStudents/Graduate%20Women%20in%20Enginee…>) News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education BME Students (ONLY): Schedule appointments with me via BoilerConnect here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>. Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [cid:image002.png@01DB30FE.418E8FD0]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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[Bmeroundtable-list] BME PhD Preliminary Exam Announcement for Sergio Ruiz Vega (H. Lee, advisor)
by May, Sandra M 06 Nov '24

06 Nov '24

BME PhD Preliminary Exam Announcement for Sergio Ruiz Vega (H. Lee, advisor) Everyone is invited to attend the public presentation beginning at 2:00 pm. Research title: Innovation on catheter designs for cerebrovascular disease treatment Date: November 20, 2024 Time: 2:00 pm Location: MJIS 2001 Thesis committee members: Hyowon Lee (chair), Chi Hwan Lee, Sunghee Park, Daniel Sahlein Abstract: Cerebrovascular diseases rank as the second leading cause of death globally, resulting in 6.2 million fatalities annually. These conditions disrupt blood flow in the brain due to vessel narrowing (stenosis), clot formation (thrombosis), artery blockage (embolism), or vessel rupture (hemorrhage). Among cerebrovascular diseases, stroke and aneurysm are the most prevalent. Stroke occurs when a blood clot obstructs an artery, impeding cerebral circulation, while an aneurysm involves the dilation of vessel walls, which can rupture if untreated. Advancements in endovascular therapies have improved the safety and efficiency of treating these conditions compared to traditional surgical methods. Neurointerventionalists can now perform minimally invasive procedures using catheters, reducing both procedure time and recovery periods. Despite these advancements in endovascular therapies, significant challenges still contribute to complications during these procedures. We introduce two catheter innovations designed to enhance the treatment of stroke and aneurysm. Mechanical thrombectomy is an endovascular therapy that employs an aspiration catheter to remove the blood clot responsible for a stroke. However, successful clot removal on the first attempt occurs in less than 25% of patients, leading to longer procedure times and reduced survival rates. To address this, we developed a passive clot-trapping microstructure at the tip of aspiration catheters, designed to increase the force applied during clot extraction. Another endovascular therapy, aneurysm embolization, involves using a detachable coil to fill the aneurysm sac, thereby reducing the risk of rupture. However, this method has been associated with long-term complications, including incomplete aneurysmal occlusion and aneurysm recurrence. To improve outcomes, we are developing a packaging-delivery device that utilizes a novel shape memory polymer, offering a patient-specific approach to aneurysm embolization therapy. These innovations have the potential to significantly improve the effectiveness and safety of stroke and aneurysm treatments, leading to better patient outcomes. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] IBSC-BME PhD Preliminary Exam Announcement for Jhon Martinez (R. Shi, advisor)
by May, Sandra M 06 Nov '24

06 Nov '24

IBSC-BME PhD Preliminary Exam Announcement for Jhon Martinez (R. Shi, advisor) Everyone is invited to attend the public presentation beginning at 3:00 pm. Title: Mechanistic Insights into Neuroprotective Strategies: Studying Neuronal Network Activity Changes in an In Vitro Model of Blast-Induced TBI Date: Thursday, November 19 Time: 3:00 pm Location: MJIS 2001and Zoom https://purdue-edu.zoom.us/j/3867778660?omn=94227865837<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Committee Members: Riyi Shi (chair), Charles Babbs, Bradley Duerstock, and Ranjie Xu Abstract: Traumatic brain injury (TBI) is a significant global public health issue, affecting up to 74 million individuals each year. In war zones, individuals are particularly vulnerable to Blast-Induced Traumatic Brain Injury (bTBI), which can result from exposure to explosive shockwaves. After the initial injury (primary injury), chemical cascades and chronic brain inflammation can further spread damage (secondary injury). Both primary and secondary injury can trigger long-term behavioral and cognitive deficiencies, including an increased risk of neurodegenerative diseases. These changes can occur even for mild injuries (mbTBI), where immediate symptoms may not be apparent. Key components of secondary injury that contribute to long-term brain pathology are oxidative stress, elevated levels of reactive oxygen species (ROS), and increased levels of acrolein. In particular, acrolein is a highly reactive aldehyde that plays a central role in exacerbating cellular damage. However, the link between cellular damage and brain pathologies remains unclear and requires a better understanding of how damage alters cell function at the cellular and sub-cellular levels. This study aims to investigate injury-related changes at the cellular level using a TBI-on-a-chip model, in which primary murine cortical neuronal networks are cultured on microelectrode arrays (MEAs), allowing recordings of neuronal activity (spikes) before and after mbTBI administration. We observed that mbTBI led to immediate functional alterations, including reduced spike rate and alterations to bursts (coordinated activity with rapid spiking) patterns, such as reduced burst rate, burst duration, and an increase in burst period. Additionally, cross-correlation analysis of MEA recordings revealed disruptions in firing order dynamics, with notable changes in firing hierarchy and the number of correlogram peaks, indicating altered temporal coordination between neurons. Furthermore, employing acrolein-scavenging drugs, such as hydralazine, helped restore aspects of network function, suggesting that neutralizing acrolein may mitigate mbTBI-induced deficits. These findings indicate that mbTBI significantly alters neuronal firing, potentially contributing to neurodegeneration, and that targeting secondary injury mechanisms, such as acrolein scavenging, could help preserve neuronal integrity and function. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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