April 2025 - Bmegradstudents-list

[Bmeroundtable-list] Wed., April 16 Seminar Speaker Kip Ludwig, PhD
by Rhonda Wolf Jones 09 Apr '25

09 Apr '25

Weldon School of Biomedical Engineering Distinguished Seminar Series Wednesday, April 16, 2025 9:30-10:20 AM, MJIS 1001 Zoom Link: https://purdue-edu.zoom.us/j/92544114610<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> "Understanding and Mitigating the Therapy Limiting Off-Target Effects of Cranial Nerve Stimulation" [cid:image001.jpg@01DBA931.2A55A870] Kip Allen Ludwig, PhD Associate Professor of Biomedical Engineering, University of Wisconsin-Madison Co-director, Wisconsin Institute for Translational Neuroengineering (WITNe) Abstract: In this talk, Dr. Kip Ludwig will discuss his experience developing neuromodulation therapies from initial concept to animal models, through to clinical trials and regulatory approval. He will focus on work at the Wisconsin Institute for Translational Neuroengineering to develop 'parallel translation' strategies to understand and improve the predictivity of animal models for success in clinical trials, and accelerate the path from concept to clinical translation. Bio: Dr. Ludwig is the Co-Director of the Wisconsin Institute for Translational Neuroengineering (WITNe) and leads the Ludwig Laboratory at the University of Wisconsin within the WITNe structure. The primary focus of his lab is developing next-generation neuromodulation therapies that use minimally invasive strategies to hack the nervous system to treat circuit dysfunction and deliver biomolecules to target areas with unprecedented precision. Prior to Wisconsin Dr. Ludwig served as the Program Director for Neural Engineering at the National Institutes of Health. He co-led the Translational Devices Program at NINDS, led the White House NIH BRAIN Initiative programs to catalyze implantable academic and clinical devices to stimulate and/or record from the central nervous system, and led a trans-NIH planning team in developing the ~250 million dollar S.P.A.R.C. Program to stimulate advances in neuromodulation therapies for organ systems. He also led the trans-NIH Advanced Neural Prosthetics Program. Dr. Ludwig also worked in Industry as a research scientist, where his team conceived, developed and demonstrated the chronic efficacy of a next-generation neural stimulation electrode for reducing blood pressure in both pre-clinical studies and clinical trials. Through his industry work he oversaw Good Laboratory Practice (GLP) and non-GLP studies enabling clinical trials in Europe and the United States, as well as participated in the protocol development and execution of those trials, leading to approval for sale in twenty countries including the United States. Dr. Ludwig connects his academic research to the neuromodulation industry and clinical translation through multiple consulting and advisory roles. He serves as the Chair of the NeuroOne Scientific Advisory Board on Artificial Intelligence, and is a member of the Scientific Advisory Board for Abbott, Battelle, Blackfynn, Cala Health, the National Center for Adaptive Neurotechnologies and Presidio Medical. He is a co-founder of Neuronoff, Inc. and NeuraWorx. Dr. Ludwig is also a paid consultant for NeuroOne, ONWARD, Restora Medical, Presidio Medical, and the Alfred Mann Foundation. ~ BME Faculty Host: Matthew Ward, PhD ~ -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME PhD Defense Announcement for Kentaro Umemori (D. Little, advisor)
by May, Sandra M 08 Apr '25

08 Apr '25

BME PhD Defense Announcement for Kentaro Umemori (D. Little, advisor) Everyone is invited to attend the public presentation beginning at 10:00 AM. Title: APPLYING TENDON STRUCTURE AND FUNCTION INTO ENGINEERED SCAFFOLDS Date: 4/22/2025 Time: 10:00AM Place: MJIS 2001 Committee: Dr. Dianne Little, Chair; Dr. Deva Chan; Dr. Luis Solorio; Dr. Vikki Weake Abstract: Rotator cuff tendon tears disrupt the balance between shoulder stability and mobility, leading to disability and reduced quality of life. With nearly half a million surgeries performed annually in the U.S., outcomes remain suboptimal due to poor healing capacity and the formation of fibrotic scar tissue with compromised mechanical strength. Tissue engineering offers a promising approach by combining biomaterials and stem cells to promote tendon regeneration. However, current biomaterials often fall short: synthetic scaffolds lack bioactivity, while biologic scaffolds fail to provide sufficient mechanical support. Most tendon tears occur at the tendon-to-bone interface, a complex, graded structure transitioning from uncalcified tendon to calcified bone, where collagen fibers shift from aligned to disorganized. This gradient is rarely replicated by existing materials, highlighting a critical need for improved scaffold designs. 3D meltblowing (3DMB) is a high-throughput fabrication process that produces highly aligned fiber scaffolds, mimicking the native tendon's collagen architecture. To date, 3DMB scaffolds have not been thoroughly evaluated for tendon repair. The goal of this study is to advance tendon tissue engineering by developing a scaffold that promotes tendon regeneration and interface healing. We first assessed 3DMB scaffolds for their suitability in tendon repair. Next, we applied mechanical stimulation to enhance tendon matrix production and simulate in vivo conditions. Finally, we aimed to stimulate development of the tendon-to-bone interface by encouraging trifunctional matrix synthesis through the combination of scaffold, tendon- and cartilage-derived matrix, and demineralized bone, providing stem cell substrates that guide differentiation into the various cell types of the native enthesis. Together, this body of work introduces translational strategies that advance the field of tendon tissue engineering and support the development of more effective treatments for tendon injuries. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME PhD Preliminary Exam Announcement for Cortland Johns (C. Goergen, advisor)
by May, Sandra M 07 Apr '25

07 Apr '25

BME PhD Preliminary Exam Announcement for Cortland Johns (C. Goergen, advisor) Everyone is invited to attend the public presentation beginning at 2:30 PM. Title: Arterial Disease Characterization in Experimental Murine Models Date: April 17th Time: 2:30 PM Location: Burton Morgan 121 or Zoom: https://purdue-edu.zoom.us/j/97172259620<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Committee Members: Dr. Craig Goergen (Chair), Dr. Benjamin Landis, Dr. Bruno Roseguini, Dr. Matthew Ward, Dr. George Wodicka Abstract: Cardiovascular disease remains the leading cause of death worldwide, with arterial diseases playing a major role in this mortality rate. Many of these conditions, including aortic aneurysm and carotid artery web (CAW) development, remain asymptomatic until life-threatening events such as rupture or stroke occur. Understanding arterial disease progression is essential for improving early detection and intervention before a medical emergency. Murine models provide a valuable method for studying vascular disease in a controlled setting, allowing for more rapid insights than can be achieved using clinical data alone. This work focuses on three key projects to enhance our knowledge of arterial disease progression. First, we will investigate the role of intraluminal thrombus (ILT) in abdominal aortic aneurysm (AAA) development using an established topical elastase and oral β-aminopropionitrile (BAPN) additive murine model. From 4D ultrasound (4DUS) images, histology, and scanning electron microscopy, we will evaluate aortic growth over time and structural changes to the vessel wall in aneurysms with and without ILT deposition. Second, we will modify the BAPN + elastase model to develop murine models of juvenile and adult thoracic aortic aneurysm (TAA). Using similar 4DUS, histology, and SEM techniques, we will compare growth and structural change between juvenile and adult mice as well as juvenile mice and juvenile humans. Third, we will establish a novel model of CAW in rats. We will confirm its location and geometry with 4DUS and will collect early visualizations of blood flow patterns using time-of-flight magnetic resonance imaging (MRI). Through these three murine models of asymptomatic arterial disease, our goal is to advance the understanding of arterial disease progression and improve decision-making for early surgical intervention. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Inaugural Purdue Engineering in Indianapolis Distinguished Lecture – Dr. Matthew Rosen (April 18)
by Rhonda Wolf Jones 04 Apr '25

04 Apr '25

Dear Colleagues, We’re thrilled to announce the inaugural Purdue Engineering in Indianapolis Distinguished Lecture Series, and we hope you’ll join us in person to celebrate this exciting milestone! Distinguished Lecturer: Dr. Matthew Rosen, Kiyomi and Ed Baird MGH Research Scholar, Director, Low Field MRI and Hyperpolarized Media Lab, Co-Director, Center for Machine Learning, Associate Professor of Radiology, Mass General/Martinos Center for Biomedical Imaging, Harvard Medical School Talk Title: "A World of Weird: Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) at 6.5 mT" 📍 Location: Innovation Hall (IO) Room 105, Purdue University in Indianapolis, Innovation Hall - IO<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fg.co%2Fkg…> 📅 Date & Time: Friday, April 18 | 2:00 PM 🚐 Shuttle Info: A Free shuttle service between West Lafayette and Indianapolis is available. The Indy drop-off/pick-up is conveniently located adjacent to Innovation Hall. Shuttle Details<https://www.purdue.edu/auxiliary-services/indianapolis/index.php> We would love to see you in person, but a virtual link is available: 🔗 Zoom Link<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> , Meeting ID: 959 6667 7729 We hope to see you there to help us celebrate this special kickoff event! Dr. Rachel Surowiec, Assistant Professor at the Weldon School of Biomedical Engineering, will be Dr. Rosen’s faculty host. Please email rsurowie(a)purdue.edu<mailto:rsurowie@purdue.edu> if you have any questions/would like to meet with Dr. Rosen. [cid:b6746216-0d85-4f1a-afde-c6d8a7628e8b] Rachel K. Surowiec, PhD Assistant Professor Weldon School of Biomedical Engineering https://engineering.purdue.edu/QBIS o: 765-495-7753 [Purdue University]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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[Bmeroundtable-list] BME Master's Defense Announcement for Andrew Frels (Y. Tong, advisor)
by May, Sandra M 04 Apr '25

04 Apr '25

BME Master's Defense Announcement for Andrew Frels (Y. Tong, advisor) Everyone is invited to attend the public presentation beginning at 12 PM. Title: Physiological Biomarkers of the Central Nervous System in fMRI Date: April 18th Time: 12 PM Location: Zoom, in person space in BME 2041 is highly limited https://purdue-edu.zoom.us/j/93647842679<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Committee: Dr Yunjie Tong, Dr. Qiuting Wen, and Dr. Riyi Shi Abstract: In functional magnetic resonance imaging the primary contrast is blood oxygen level dependent (BOLD) signal, changes of which are caused by a number of factors. Filtering the BOLD signal to the low frequency oscillation (LFO) band (0.01-0.1 Hz) yields the long-term fluctuations in signal from metabolic or systemic changes. A prominent component of the LFO band has been shown to originate from outside the brain, dubbed the systemic LFO (sLFO). Correlating averaged regional sLFO signals acts as an endogenous bolus to track the flow of blood. Shifts between maximal correlation correspond to the relative delay of blood arrival at these regions of interest. This provides a useful and non-invasive method to evaluate blood flow changes. In Sickle Cell Disease (SCD) this method was used to evaluate the abnormal blood flow common within the condition. In healthy patients, the relationship between the brain and its major venous outflow, the superior sagittal sinus (SSS), was normal with the SSS lagging. However, it was found that in all SCD individuals there was also a leading signal, possibly suggesting two pathways for blood to reach the SSS. These are hypothesized to be a normal pathway through the capillary bed and an alternative shunted pathway wherein blood flow bypasses the capillary bed and highly oxygenated blood reaches the venous system. Novelly, the magnitude of this shunted pathway signal increased with disease severity, implying a novel biomarker for SCD progression. Similarly, the hemodynamic relationship between the brain and spinal cord, an under-investigated topic, was assessed using sLFO techniques. It was found that the brain-spinal cord relationship is comprised of two distinct signals, one with the spinal cord leading the brain and one with it lagging. The early signal is proposed to be carried by arterial flow, reaching the spinal cord before the brain. The late path is believed to be outflow from the brain via the vertebral venous plexus, a network of veins connecting the lower brain to the cervical spine. This could provide a valuable biomarker for vascular damage in spinal cord injury. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] FW: BME Spirit Week: Whose that baby!
by Rhonda Wolf Jones 04 Apr '25

04 Apr '25

[cid:image001.png@01DBA53E.44736450] [cid:image003.jpg@01DBA2E1.B6840BD0][cid:image004.jpg@01DBA2E1.B6840BD0] -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Purdue MRI Faculty Candidate with expertise in Diffusion MRI and Aging/Neurodegeneration
by Kevin John Otto 03 Apr '25

03 Apr '25

Attached is the seminar flier for Dr. Gabriel Ramos Llordén, a faculty candidate in the area of MRI, who will be on campus next week interviewing for the open Medical Physics faculty position in the School of Health Sciences. Seminar: "Diffusion MRI for Neuroscience: Probing Brain Structure and Microstructure In Vivo"" Gabriel Ramos Llordén, PhD Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Harvard Medical School Monday, April 7, 2025 ARMS 3115 11:45 a.m. - 12:45 p.m. (EDT) You are cordially invited to attend his Seminar, and if you want to meet with this candidate, please contact Karen Walker under kwalker(a)purdue.edu<mailto:kwalker@purdue.edu> Thanks! Ulrike Ulrike Dydak Professor, School of Health Sciences Director, Purdue Life Science MRI Facility<https://www.purdue.edu/hhs/mri/> Director, Medical Physics and Imaging Sciences Programs<https://hhs.purdue.edu/graduate-programs/medical-physics-graduate-program-c…> Associate Director, Women's Global Health Institute<https://www.purdue.edu/discoverypark/WGHI/> Purdue University 550 Stadium Mall Drive West Lafayette, IN 47907 phone: (765) 494 0550 email: udydak(a)purdue.edu<mailto:udydak@purdue.edu>

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[Bmeroundtable-list] BME Master's Defense Announcement for Victoria Sinfield (Y. Tong and M. Shader, co-advisors)
by May, Sandra M 03 Apr '25

03 Apr '25

BME Master's Defense Announcement for Victoria Sinfield (Y. Tong and M. Shader, co-advisors) Everyone is invited to attend the public presentation beginning at 1:45pm. Title: Systemic noise correction and integration of neurophysiological and behavioral measures in fNIRS for enhanced cognitive load analysis Date: April 11th Time: 1:45 PM Location: Creighton Hall (CRTN) 1011 and Zoom: https://purdue-edu.zoom.us/j/95438047996<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Committee Members: Dr. Yunjie Tong (co-chair), Dr. Maureen Shader (co-chair), Dr. Anne Sereno Abstract: Functional near-infrared spectroscopy (fNIRS) is a valuable neuroimaging technique for studying cognitive processes, offering a non-invasive way to measure hemodynamic responses associated with cortical activity during naturalistic tasks. However, systemic-physiological noise - originating from factors such as respiration, heart rate, and extracerebral tissue - compromises neural signal accuracy and test-retest reliability. To address this, we conducted a comprehensive analysis of noise correction methods across repeated sessions of a passive auditory task. While certain correction approaches reduce reliability metrics by removing global systemic noise, which can artificially bolster reliability, regressing out these artifacts improves the accuracy and interpretability of the auditory-evoked neural response. Building on these findings, we applied an optimized correction approach to an independent active experiment examining the effects of varying forms of auditory cognitive load on sentence recognition in younger and older adults. Cognitive load was manipulated through two factors: stimulus length and stimulus speed. Behavioral measures included delayed recall task performance and standardized cognitive assessments, while neurophysiological measures encompassed fNIRS-derived cortical hemodynamics and systemic-physiological signals. Results indicate that task accuracy and physiological responses are differentially modulated by cognitive load type and age, with neural engagement decreasing when cognitive demands exceed an individual's capacity, particularly in older adults. Additionally, behavioral data suggest age-related differences in the cognitive strategies used to manage these load conditions. These findings contribute to a more nuanced understanding of the relationship between cognitive load, neural processing, and age-related cognitive adaptation in auditory and speech perception. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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FW: Posters
by Rhonda Wolf Jones 03 Apr '25

03 Apr '25

Good Morning - Yesterday, I noticed some of the posters coming out of the poster printer had a very old logo/setup on them. The old has the blue/yellow top. For future projects, could you remind the students to use the brand-approved template? The Weldon School can be found on our website here: https://engineering.purdue.edu/BME/Communications. There are also templates on MarCom's website here: https://marcom.purdue.edu/toolbox/templates/all-templates/?media=ms-office. I appreciate your help in keeping us all in line with brand standards. Boiler Up! Rhonda Jones (she/her/hers) Senior Marketing and Communications Professional Weldon School of Biomedical Engineering O 765.494.3940 | C 765.427.2065 rwjones(a)purdue.edu<mailto:rwjones@purdue.edu> [cid:image001.jpg@01DBA487.FAEB81C0]

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[Bmeroundtable-list] Wednesday seminar: Dr. Shuichi Takayama on Lung & other Microphysiological Systems
by Rhonda Wolf Jones 03 Apr '25

03 Apr '25

[cid:image001.png@01DBA482.1A810B50] BME DISTINGUISHED RESEARCH SEMINAR SERIES Wednesday, April 09, 2025 9:30 - 10:20 am, MJIS 1001 ZOOM LINK: https://purdue-edu.zoom.us/j/93634966285<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> *Note: Students enrolled in the seminar course are expected to attend in person. "Lung & Other Microphysiological Systems" [cid:image004.png@01DBA482.2140F310] Dr. Shuichi Takayama Associate editor of Integrative Biology, Recipient of the Pioneers of Miniaturization Prize and Steven A. Denning Faculty Award for Global Engagement, Director of the Nakatani RIES Program Abstract: This presentation will describe efforts in our lab to develop microphysiological systems (MPSs) *such as organs-on-a-chip or Transwell cultures and organoids* of the lung. The talk will start with microfluidic small airway models that combine in-channel air-liquid interface culture with liquid plug propagation and rupture under conditions of surfactant dysfunction. Transwell-96 based air-blood barriers model will be described that facilitates virus infections studies and also promises to accelerate studies of effects of air pollution on lung inflammation. The presentation will also describe airway organoids that have an inverted, apical-out geometry. These Organoids with Reversed Biopolarity (ORBs) are used in 384 well plates in a single-organoid-per-well format to test drugs and disease physiology. The airway ORBs are infected with high yields with multiple SARS-CoV-2 strains; the Omicron variant showing the highest viral replication and the Delta variant inducing a higher inflammatory signature. The airway ORBs also predict anti-viral drug efficacy correctly where conventional 2D cultures give false signals. Time permitting studies using human intestinal organoids and mammary organoids that mimic early-stage breast cancer progression will also be briefly covered. Biography: Prof. Shuichi Takayama's research interests started with bioorganic synthesis at the University of Tokyo and Scripps Research Institute. Subsequently he pursued postdoctoral studies in bioengineered microsystems at Harvard University as a Leukemia and Lymphoma Society Fellow. He spent 17 years at the University of Michigan in the Biomedical Engineering Department and Macromolecular Science and Engineering Program, then moved to the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory School of Medicine in the summer of 2017. He is an associate editor of Integrative Biology and recipient of the Pioneers of Miniaturization Prize and Steven A. Denning Faculty Award for Global Engagement. He is Director of the Nakatani RIES Program which promotes international undergraduate student internships between the US and Japan. ~ BME Host: Estelle Park ~ -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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