April 2025 - Bmegradstudents-list

[Bmeroundtable-list] BME PhD Preliminary Exam Announcement for Barrett Davis (T. Kinzer-Ursem, advisor)
by May, Sandra M 21 Apr '25

21 Apr '25

BME PhD Preliminary Exam Announcement for Barrett Davis (T. Kinzer-Ursem, advisor) Everyone is invited to attend the public presentation beginning at 2:00 pm. Title: A Structured Approach to Developing Mechanistic Models of Biological Systems Interactions across Scales Date: May 2nd, 2025 Time: 2:00 pm Location: MJIS 2001 and Zoom Zoom Link: https://purdue-edu.zoom.us/j/93692421121?pwd=6DswLzRxWgQCbFuhzkqxERTIWle5It…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Meeting ID: 936 9242 1121 Passcode: twobricks Committee: Dr. Tamara Kinzer-Ursem (chair), Dr. Elsje Pienaar, Dr. Luis Solorio, Dr. Kevin Webb Abstract: Mechanistic computational models provide a quantitative means to study complex systems interactions within a theory-based framework not otherwise afforded by similar, statistical approaches. However, challenges to model construction, especially the sparsity of parameter data relative to the density of biochemical interaction networks, limits the predictive power and ready application of these models to clinical research. In response to this, here I propose an approach to characterizing biological system interactions from atoms to action potentials in two aims. The first aim details a new method for the cleanroom-free manufacture of an optical biosensing platform to measure the label-free interaction kinetics of single molecules in free-solution. Accompanying this, I develop a biophysical model to interpret this platform's experimental results, including association and dissociation rates, as well as the translational and rotational diffusivities of individual molecules. In the second aim, I create a compartmental model to simulate differences in the activity-dependent synaptic plasticity of typical, excitatory hippocampal neurons and those with SYNGAP1 haploinsufficiency (SG+/-), a rare neurodevelopmental disorder. Simulated small molecule and genetic therapies alike are explored for their potential to recapitulate typical synaptic plasticity in the SG+/- system. Global sensitivity analyses are used to quantify first, second and total-order interaction sensitivities of the plasticity model and to rationally prioritize any future parameterization efforts. Together these studies provide an approach to efficiently parameterize biochemical models and to trial new therapeutics in silico, with immediate applications for both historically understudied rare diseases and basic biomedical sciences more broadly. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

1 0

Wheel RIISE 2025 Invitation
by Siemers, Tammy R 21 Apr '25

21 Apr '25

Wheel RIISE is an annual event that connects adaptive sports and engineering to bring the Midwest adaptive sports community together. This event will feature wheelchair basketball exhibition games with local and collegiate players, Purdue students, and community members. It is also an opportunity to showcase engineering designs from our development team aimed at advancing adaptive sports. This event is free and open to the public and is aimed at celebrating and educating the public about adaptive sports! Allison Lisota BS Biomedical Engineering - December 2024 MS Biomedical Engineering - May 2025 Operations Director - Purdue RIISE [cid:786acdc1-9a71-4b61-9328-d06fe771d874]

1 0

[Bmeroundtable-list] BME Research Symposium - don't forget to register
by Rhonda Wolf Jones 16 Apr '25

16 Apr '25

[cid:image001.png@01DBA7AD.500C0F30] -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

2 1

Weldon Graduate Program Announcements April 16th, 2025
by Siemers, Tammy R 16 Apr '25

16 Apr '25

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements April 16th, 2025 * Career and Internship Opportunities * BME Beats on April 23rd * 2025 Conference on the Changing Brain with CNCM, Allen Institute, and the Cajal Club * Summer Workshop for Dissertation and Thesis Writing at the OWL * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Clinical R&D Engineer Co-op, Abbott<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Cell Therapy Automation Intern, Legend Biotech<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Clinical Trial Landscape Intern, Legend Biotech<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * QC Intern, Legend Biotech<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * R&D Intern, Legend Biotech<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * 2025 Co-op, Regeneron<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> Postdoctoral Positions * NPA Website: https://careers.nationalpostdoc.org/jobs/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.n…> Full Time Positions * Biomedical Research Engineer, Cook Medical<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Biomedical Engineering Imaging Project Coordinator, Medpace<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Human Factors Engineer/Usability Engineer, Amgen<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.simpl…> * Biomedical Engineering Fellowship, Blast Induced Neurotrauma, Oak Ridge Institute<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Associate Clinical Specialist, Medtronic<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> * Other regions available if you search * Purdue Start-up Job Board<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurduefou…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.a…>-Association for Clinical and Translational Science * Academic Careers<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Facademicc…> * Doc Jobs<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.docjo…>-Jobs beyond traditional clinical and academic roles BME Beats on April 23rd [cid:image002.png@01DBAED7.343100F0] 2025 Conference on the Changing Brain with CNCM, Allen Institute, and the Cajal Club 2025 Conference on the Changing Brain with CNCM, Allen Institute, and the Cajal Club<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Ft.e2ma.ne…> Join us for this summer's Conference on the Changing Brain, to be held August 18-20 in Irvine, California. Jointly sponsored by the Allen Institute, the UCI Center for Neural Circuit Mapping (CNMC), and the Cajal Club, the conference will focus on neural circuit studies in health and disease, with six sessions covering the following topics: The Evolving Brain * The Developing Brain * The Learning Brain The Dynamic Brain * States of the Brain * The Disordered Brain REGISTER BY MAY 19<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Ft.e2ma.ne…> CONFERENCE INFO<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Ft.e2ma.ne…> Summer Workshop for Dissertation and Thesis Writing at the OWL The Purdue OWL is offering the Intensive Writing Experience for Thesis and Dissertation Writers (IWE) again this summer. The purpose of the IWE is to give graduate students in good standing with their programs time to write or revise their master's thesis or doctoral dissertation with support from Purdue OWL staff. Participants will receive writing instruction and support from Writing Lab staff, will spend significant time writing or revising their thesis or dissertation, and will network with other graduate writers on campus. Those who attended a previous IWE are allowed to apply, but preference will be given to those who have not yet attended. Writers can choose between a full-day virtual week (3 full days), a full-day in-person week (3 full days), or a half-day in-person week (5 half days, mornings). * May 13-15 (virtual, 8:30 am to 5:00 pm) * May 20-22 (in-person, 9:00 am to 4:30 pm) * May 27-29 (in-person, 9:00 am to 4:30 pm) * June 2-6 (in-person, 8:30 am to 12:30 pm) KEY INFORMATION: Application Period: April 14-23, 2025 Eligibility: Master's or PhD students completing a thesis or dissertation How to Apply: Complete the application survey here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> beginning April 14, 2025. Application requires advisor consent. For more information, see the information sheet<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdrive.goo…> or email Writing.Lab(a)purdue.edu<mailto:Writing.Lab@purdue.edu> and include IWE in the subject line. Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. Apr. 16th Experiences in Women's and Sexual Health (CCO<https://www.cco.purdue.edu/Calendar/Event/485>) Apr. 16th NIH Fellowship Opportunities for Grad Students (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Apr. 16th NIH Fellowship Opportunities for PhD Candidates & Postdoctoral Scholars (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Apr. 16th Sleeping for Success (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Apr. 16th 2025 Just in Time Career Fair (CCO<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-cs…>) Apr. 16th Multicultural Engagement for Researchers & Grads in Engineering (MERGE) Event (COE<https://engineering.purdue.edu/Engr/Academics/Graduate/Events/multicultural…>) Apr. 17th BME Research Symposium in DLR 131 (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.goog…>) Apr. 17th SACNAS Callout Brunch (11:30a-12:30p, Native American Educ. & Cultural Ctr., brunch first come first serve) Apr. 18th Biotech Fizzle Friday w/CBC Entrepreneurial Fellows (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fnorthwest…>) Apr. 21st Deadline to Register for GLCACS 27th Annual Conference (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.goog…>) Apr. 23rd BME Beats feat. Marco Prado & Ben Zeidler (MJIS Atrium, 9:15 am) Apr. 23rd Deadline to apply for Purdue OWL Summer Workshop for Thesis & Dissertation Writers (OWL<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>) Apr. 25th How to be a Good Reviewer (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Apr. 25th Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Apr. 28th & 29th Future Faculty Boot Camp (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) Apr. 30th Abstract Submission Deadline for IQVIA Institute Research Forum (IQVIA<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fapp.smart…>) May 5th Interactive Fellowship Office Hour (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 7th Interactive Fellowship Office Hour (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 9th Postdoc Power Session (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 19th Deadline to register for UCI 2025 Conference on the Changing Brain (Register<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fna.events…>) May 21st NIH Fellowship Opportunities for Grad Students (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 21st NIH Fellowship Opportunities for PhD Candidates & Postdoctoral Scholars (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) May 30th Postdoc Coffee Chat (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 4th NIH Fellowship Opportunities for Graduate Students (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 4th NIH Fellowship Opportunities for PhD Candidates & Postdoctoral Scholars (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 6th RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) June 27th RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) July 18th RCR: Discipline-Specific Training (GSPD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgspd.gosi…>) News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education BME Students (ONLY): Schedule appointments with me via BoilerConnect here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…>. Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [cid:image003.png@01DBAED7.343100F0]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

1 0

THIS FRIDAY: Dr. Matt Rosen (MGH)- Help Us Launch the First Purdue Engineering in Indianapolis Distinguished Lecture!
by Sherry Clemens 16 Apr '25

16 Apr '25

Colleagues, Please help us launch the First Purdue Engineering in Indianapolis Distinguished Lecture series here in Indianapolis THIS FRIDAY (April 18th) at 2PM, Innovation Hall Rm 105 (refreshments served before event) We are kicking things off with a true force in the (magnetic)field: Dr. Matt Rosen. Matt is a disruptor, innovator, and visionary thinker. He directs the Center for Machine Learning at Harvard, leads a wildly creative and productive lab, and founded several startups (check out Hyperfine, the first portable MRI!), is a musician, and gave the keynote lecture at last year’s ISMRM, the largest MRI conference in the world- all to say this is a wildly cool opportunity to meet him and hear him speak in an intimate/small setting. Distinguished Lecturer: Dr. Matthew Rosen, Kiyomi and Ed Baird MGH Research Scholar, Director, Low Field MRI and Hyperpolarized Media Lab, Co-Director, Center for Machine Learning, Associate Professor of Radiology, Mass General/Martinos Center for Biomedical Imaging, Harvard Medical School Talk Title: "A World of Weird: Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) at 6.5 mT" 📍 Location: Innovation Hall (IO) Room 105, Purdue University in Indianapolis, Innovation Hall - IO<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fg.co%2Fkg…> 📅 Date & Time: Friday, April 18 | 2:00 PM 🚐 Shuttle Info: A Free shuttle service between West Lafayette and Indianapolis is available. The Indy drop-off/pick-up is conveniently located adjacent to Innovation Hall. Shuttle Details<https://www.purdue.edu/auxiliary-services/indianapolis/index.php> We would love to see you in person, but a virtual link is available: 🔗 Zoom Link<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> , Meeting ID: 959 6667 7729 We hope to see you there to help us celebrate this special kickoff event! Rachel K. Surowiec, PhD Assistant Professor Weldon School of Biomedical Engineering https://engineering.purdue.edu/QBIS o: 765-495-7753 [Purdue University]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

1 0

ECE Hosted Seminar: "Foundation Models and Generative AI for Medical Imaging Segmentation in Ultra-Low Data Regimes" - Tomorrow, April 16th
by O'Neal, Crystal D 15 Apr '25

15 Apr '25

All interested BME faculty and students are invited to attend Professor Pengtao Xie's seminar titled "Foundation Models and Generative AI for Medical Imaging Segmentation in Ultra-Low Data Regimes". The seminar is being held tomorrow, April 16th, from 4-5 pm in MSEE 112. If you have any questions, please reach out to Assistant Professor Xiaoquian (Joy) Wang, joywang(a)purdue.edu<mailto:joywang@purdue.edu>. IN PERSON ATTENDANCE IS HIGHLY ENCOURAGED Zoom link: https://purdue-edu.zoom.us/j/93267796938<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Meeting ID: 932 6779 6938 [cid:image001.png@01DBAE00.CAA733B0]

1 0

Opportunity for Purdue Biomed Students: Scholarship & Virtual Biomed Career Meet and Greet
by Siemers, Tammy R 15 Apr '25

15 Apr '25

From: Steven Szymeczek <steven(a)ed2s.org> Sent: Monday, April 14, 2025 6:57 PM To: Holderbaum, Cynthia L <cholderb(a)purdue.edu>; Siemers, Tammy R <tsiemers(a)purdue.edu>; Render, Darshini N <render(a)purdue.edu> Subject: Opportunity for Purdue Biomed Students: Scholarship & Virtual Biomed Career Meet and Greet You don't often get email from steven(a)ed2s.org<mailto:steven@ed2s.org>. Learn why this is important<https://aka.ms/LearnAboutSenderIdentification> ---- External Email: Use caution with attachments, links, or sharing data ---- Purdue Biomedical Engineering - Hope you are all doing well! I am a director for Education2Success, part of an independent 501C3 nonprofit organization working with Universities through our innovation workforce advancement programs (iat1.org<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fiat1.org%2…>) We successfully completed a program with Purdue and Bayer Crop Science recently, with great success (https://www.iat1.org/post/bayer-iat-regenerative-agriculture-a-collaborativ…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.iat1.…>). We are now looking to offer new programs for Purdue students in Biomedical! Reason for reaching out - We are looking for more applicants for our Virtual Career Meet and Greet: Biomedical Focus, happening this Thursday April 17th. Very excited for the program meet and greet, as we have added attending industry members from orthopedic implant and 3d printed surgical guides - RMS, Ricoh Healthcare 3D, and Mayo Clinic. Please pass this along directly to your Biomedical focused students as it will be a great opportunity for them to interact with industry and a chance for a scholarship! Info for students to Apply Submit your resume directly to steven(a)ed2s.org<mailto:steven@ed2s.org> Along with a 2 paragraph statement illustrating: ✔️ Why innovation matters to you ✔️ A biomedical challenge you’re passionate about solving Also happy to set a time to meet individually to discuss our programs more, my availability is here: https://calendar.app.google/ZiuWnRwXWo1TZpG2A<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcalendar.…> Thanks so much for sharing this opportunity! Steven Szymeczek LinkedIn Profile<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linke…> Director, Innovate-A-thon Education2Success iat1.org<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fiat1.org%2…> --------- Innovation Scholarship and Career Showcase Innovation is the driving force behind industry growth. Are you ready to join and excel in the innovation workforce? Join us for an exclusive Virtual Career Meet & Greet where you are eligible to receive scholarships and direct connections for internships and early career positions with top companies in the Biomedical Industry. At this event you can elevate your career, connect with industry leaders, and showcase your hands-on innovation skills! 🔹 What is an Innovation Career Meet & Greet? Our Talent Meet & Greets combine the best aspects of virtual career fairs while eliminating their common challenges. Unlike traditional open career fairs where students have difficulty aligning with direct requirements for typical open positions, our approach is designed to give you direct access to the most promising employers who are seeking your specific talents! Unlike other career fair type opportunities, our Meet & Greets are limited to 30 students and 20 industry members–all focused on the topic of the event. No waste of time roaming between recruiters and hoping you are a fit. 🔹 Why Attend the Career Meet & Greet? · Network with industry professionals looking for specific and emerging talent. · Explore career pathways in Biomedical innovation and technology. · Discover how you can earn additional scholarships ($450-$600) while building real-world expertise in our accompanying program Innovate-A-thon (not required for Meet & Greet) 🔹 Who Should Apply? Students from all disciplines who are passionate about innovation in the biomedical sector. Eligible applicants include: ✅ Undergraduate juniors and seniors ✅ Graduate students Info for students to Apply Submit your resume directly to steven(a)ed2s.org<mailto:steven@ed2s.org> Along with a 2 paragraph statement illustrating: ✔️ Why innovation matters to you ✔️ A biomedical challenge you’re passionate about solving Only excellent applications will be accepted. We encourage you to spend a little time on your submission materials – The top 2 applicant submissions will receive scholarships of $300 and $200! Those top 2 applicants will each give a 5 min presentation at the event showcasing their winning submission–accelerating their visibility from among other applicants. Scholarships will be posted to bursar accounts following Meet & Greet and upon receipt of student ID information. 🚀 Be part of the event will put you at leading edge of new innovative careers that are shaping the future of industry! Event Date Thursday April 17th First session: 12-2 ET Second Session: 3-5 ET Want to learn more about this opportunity before you apply? Reach out directly to steven(a)ed2s.org<mailto:steven@ed2s.org> for questions. Steven Szymeczek Director, Innovate-A-thon Program [https://ci3.googleusercontent.com/mail-sig/AIorK4zHYM3DSJXzbzxgy6HcbxiR-uXe…] Board President [https://ci3.googleusercontent.com/mail-sig/AIorK4zlUDfd9zYucNekU2NVZjaytmz-…] 3dprintingmentality.com<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2F3dprinting…>

1 0

[Bmeroundtable-list] Postponed: BME PhD Preliminary Exam Announcement for Christopher Schorr (K. Lee, X. Bao and S. Harbin, advisors)
by May, Sandra M 15 Apr '25

15 Apr '25

Please note that Christopher Schorr's preliminary exam has been postponed and will be re-scheduled for a future date. From: May, Sandra M <smmay(a)purdue.edu> Sent: Friday, April 4, 2025 8:29 AM To: bmeroundtable-list(a)ecn.purdue.edu Cc: May, Sandra M <smmay(a)purdue.edu> Subject: BME PhD Preliminary Exam Announcement for Christopher Schorr (K. Lee, X. Bao and S. Harbin, advisors) BME PhD Preliminary Exam Announcement for Christopher Schorr (K. Lee, X. Bao and S. Harbin, advisors) Everyone is invited to attend the public presentation beginning at 1:00 pm. Title: Elucidating the Kinase-Independent Regulation of PIM2 in Multiple Myeloma Date: April 16th, 2025 Time: 1:00 pm Zoom link: https://iu.zoom.us/j/82335784398<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fiu.zoom.u…> Committee: Dr. Kelvin Lee, Dr. Xiaoping Bao, Dr. Sherry Harbin, Dr. Michael Heinz Abstract: Multiple myeloma (MM) remains an incurable hematologic malignancy with poor prognosis due to the inevitable development of drug resistance. A key driver of MM progression and therapeutic failure is the overexpression of the oncogenic kinase PIM2, which promotes cancer cell survival through both kinase-dependent and kinase-independent mechanisms. Despite significant overexpression in MM and association with poor outcomes, ATP-competitive PIM2 inhibitors have shown limited efficacy in clinical trials. In contrast, our laboratory's non-ATP competitive inhibitor JP11646 demonstrates superior efficacy by downregulating PIM2 gene expression, suggesting mechanisms beyond simple kinase inhibition. This research investigates the hypothesis that PIM2 maintains its constitutive overexpression in MM through a kinase-independent autoregulatory feedback loop involving the oncogenic transcription factors MYC and SP1. Through chromatin immunoprecipitation, protein interaction studies, and luciferase reporter assays, we demonstrate that both wild-type and kinase-dead PIM2 localize to the nucleus, associate with MYC and SP1, and bind to the PIM2 promoter. We identify critical SP1 binding sites in the PIM2 promoter region essential for this regulation, with mutation of these sites significantly reducing PIM2 expression. Disruption of the PIM2-MYC-SP1 complex through JP11646 treatment, but not through ATP-competitive inhibition, significantly reduces PIM2 expression and MM cell viability. These findings reveal a novel kinase-independent autoregulatory mechanism that maintains high PIM2 levels in MM cells and provides a potential explanation for the limited efficacy of conventional PIM2 kinase inhibitors. This work identifies a previously uncharacterized vulnerability that could be exploited to develop more effective targeted therapies for MM patients. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

1 0

Weldon BME Grad Student Townhall
by Kevin John Otto 14 Apr '25

14 Apr '25

Hi all, I appreciate that current events have contributed to a lot of uncertainty. I'd like to hear from you about what's most pressing on your mind. I'm also happy to share what I know or can speculate. * Please join me for a townhall on April 14 (details below). * I don't have a set agenda. Rather, during this townhall I will level-set our foundation and then open the floor for discussion. I welcome you to come and share your thoughts, ask questions, or just listen to the discussion. * You are welcome to join online or in-person. I also welcome topics/questions sent directly to me in advance of the townhall. [cid:image001.jpg@01DBA86C.CA433CA0] -- Kevin Otto, Ph.D. Dane A. Miller Head and Professor Weldon School of Biomedical Engineering [Purdue University, 150 years of Purdue Engineering] **My email may come at odd hours. My work hours may not be your work hours. Do not feel obliged to reply outside of your normal working day**

1 2

[Bmeroundtable-list] BME Master's Defense Announcement for Alec Booth (K. Jayant, advisor)
by May, Sandra M 14 Apr '25

14 Apr '25

BME Master's Defense Announcement for Alec Booth (K. Jayant, advisor) Everyone is invited to attend the public presentation beginning at 2:30 pm. Title: Chronic Multimodal Platform for Simultaneous Electrophysiology and Calcium Imaging Date: April 16, 2025 Time: 2:30 pm Location: MRGN 121 Zoom: https://purdue-edu.zoom.us/j/97997817149<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Committe Members: Dr. Krishna Jayant (Chair), Dr. Kevin Otto, Dr. Scott Pluta Abstract: Neural technologies that combine high-density electrophysiology with nonlinear optical imaging in deep-scattering tissue are crucial for understanding population-level neural dynamics in active behaving preparations. Although acute experiments have been demonstrated, chronic multimodal approaches can provide unmatched insight into neural processes that evolve over many days, such as learning. Such insights, however, have remained unattainable due to technological barriers. Here, we present a novel platform for simultaneous electrophysiological recording and two-photon calcium imaging across months in the awake mouse brain. This system is supported by a custom-engineered, lightweight head stage optimized for chronic studies and an integrated analysis pipeline for multimodal data processing. Using this platform, we investigated the dynamics of motor learning by examining the spatiotemporal organization of population-level activity with single-cell resolution. Throughout a mouse's progression from novice to mastery in a repetitive motor learning task such as the lever-pull task, neural ensembles gradually showed increased sparsity and representational stability, possibly reflecting a shift in encoding strategy across the learning spectrum. This sparse representation was synonymous with a lowering in traveling wave speed, attributed to increased inhibition in the circuit. In addition, this methodological approach also established a technique for the chronic implantation of flexible, penetrating depth probes that conform to brain micromotion, which reduces inflammation and extends recording longevity. Together, these advances overcome critical hurdles in chronic neural interfacing, laying the foundation for long-term studies of neural dynamics, learning, and disease progression. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

1 0