BME PhD Preliminary Exam Announcement for Cortland Johns (C. Goergen, advisor) Everyone is invited to attend the public presentation beginning at 2:30 PM. Title: Arterial Disease Characterization in Experimental Murine Models Date: April 17th Time: 2:30 PM Location: Burton Morgan 121 or Zoom: https://purdue-edu.zoom.us/j/97172259620<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F97172259620&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C5764e1d348994812964808dd7617736c%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638796565285476556%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=EtoQP3L3w3SVcn4sCLMwNnVWK7TRhVecdbiGGqOzi%2FY%3D&reserved=0> Committee Members: Dr. Craig Goergen (Chair), Dr. Benjamin Landis, Dr. Bruno Roseguini, Dr. Matthew Ward, Dr. George Wodicka Abstract: Cardiovascular disease remains the leading cause of death worldwide, with arterial diseases playing a major role in this mortality rate. Many of these conditions, including aortic aneurysm and carotid artery web (CAW) development, remain asymptomatic until life-threatening events such as rupture or stroke occur. Understanding arterial disease progression is essential for improving early detection and intervention before a medical emergency. Murine models provide a valuable method for studying vascular disease in a controlled setting, allowing for more rapid insights than can be achieved using clinical data alone. This work focuses on three key projects to enhance our knowledge of arterial disease progression. First, we will investigate the role of intraluminal thrombus (ILT) in abdominal aortic aneurysm (AAA) development using an established topical elastase and oral β-aminopropionitrile (BAPN) additive murine model. From 4D ultrasound (4DUS) images, histology, and scanning electron microscopy, we will evaluate aortic growth over time and structural changes to the vessel wall in aneurysms with and without ILT deposition. Second, we will modify the BAPN + elastase model to develop murine models of juvenile and adult thoracic aortic aneurysm (TAA). Using similar 4DUS, histology, and SEM techniques, we will compare growth and structural change between juvenile and adult mice as well as juvenile mice and juvenile humans. Third, we will establish a novel model of CAW in rats. We will confirm its location and geometry with 4DUS and will collect early visualizations of blood flow patterns using time-of-flight magnetic resonance imaging (MRI). Through these three murine models of asymptomatic arterial disease, our goal is to advance the understanding of arterial disease progression and improve decision-making for early surgical intervention. -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list