July 2022 - Bmegradstudents-list

[Bmeroundtable-list] BME Summer Seminar Announcement: July 20th 9:30-10:30am EST via Zoom
by Rowen, Elizabeth Pearl 18 Jul '22

18 Jul '22

[cid:image002.jpg@01D89A95.A56C4350] BME Summer Seminar Series Wednesday, July 20th, 2022 9:30-10:30AM EST Via Zoom Meeting - link below* Evaluation links: Om Kolhe: https://purdue.ca1.qualtrics.com/jfe/form/SV_9XBGSuWVQakqYiG Julia Walsh: https://purdue.ca1.qualtrics.com/jfe/form/SV_8kofpIjUVQBJAou Integrated CMOS Neural Amplifier for Multiparameter Recording Om Kolhe (K. Jayant, advisor) [cid:image005.jpg@01D89A95.A583EA00] Abstract: Dopamine is one of the most important neurotransmitters in the brain and plays an important role in body functions, including movement, memory, reward and motivation. The role of dopamine in learning and motivation has been vastly studied and it is believed that the 'slow' (tonic) changes in dopamine modulates motivation, and the 'fast' (phasic) fluctuations encodes reward prediction error. However there have not been many studies exploring the role of dopamine in memory consolidation. It is postulated that a ventral tegmental area (VTA)-hippocampus dopaminergic loop controls the entry of information into long-term memory. This dopaminergic loop can be better studied if we can detect how dopamine levels modulate the neural firing patterns of cells in the hippocampus. Thus, we designed and fabricated a multichannel CMOS circuit in TSMC's 180nm technology node, which can perform simultaneous electrochemistry (EChem) and electrophysiological (EPhys) recording in-vivo. The circuit consists of a transimpedance amplifier (TIA) for EChem recording and a neural amplifier for EPhys recording. Both the circuits are chopper stabilized to push the flicker noise corner to 10 Hz thus improving the noise performance at low frequencies. The TIA is a switch capacitor amplifier with configurable gain and can perform constant voltage amperometry as well as fast scan cyclic voltammetry for detection of dopamine at sub-second time scales. The neural amplifier a bandwidth of 5kHz encompassing both local field potentials (LFP) and neural spikes. Our future work aims to fabricate an implantable flexible neural probe which can integrate with the recording circuit. The system will be then implanted in a mouse brain, while the mouse performs reward-based decision tasks in a virtual reality environment. Evaluation and Comparison of Anti-biofouling Coatings for Implantable Biosensors Julia Walsh (H. Lee / S. Harbin, advisor) [https://engineering.purdue.edu/ResourceDB/ResourceFiles/image243540/alter?b…] Abstract: Biosensors are used in the treatment and diagnosis of a variety of illnesses, including Diabetes and COVID-19. They are a promising part of the treatment of many health conditions that require continuous monitoring. However, despite the growing versatility of these sensors, development of implantable continuous biosensors is limited by short lifetimes. This is largely attributable to fouling with biological molecules and cells as part of the foreign body response. To improve on sensor lifetimes, many groups have created coatings and surface treatments intended to prevent fouling of the surface by biological particles. However, due to differences in the methods used to assess the coatings in these studies, it is impossible to say which approaches work best. Our goal is to carry out standardized testing of a large variety of antifouling techniques to assess which work best to prolong of sensor lifetime and limit immunogenicity. To measure sensor lifetime, we have created a basic enzymatic glucose biosensor that can use amperometry to assess function over time. This technique will be used in combination with cell cultures and in vivo continuous glucose monitoring to measure sensor lifetime under different conditions. To assess immunogenicity, we have been working with the Dunn Lab to carry out intravital microscopy analysis of the coatings we are testing. This technique allows for the real-time monitoring of the immune response to the coatings through microscopy. This technique along with protein assays will be used to assess the interaction of the coatings with biological environments. *Join Zoom Meeting https://purdue-edu.zoom.us/j/92168739019?pwd=cnBOaFBxN3FWVVVTWC8wWWhaekdIdz… Meeting ID: 921 6873 9019 Passcode: biomedical Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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BME-IBSC PhD Preliminary Exam Announcement for Seul Ah Lee (Chi Hwan Lee, advisor)
by May, Sandra M 15 Jul '22

15 Jul '22

BME-IBSC PhD Preliminary Exam Announcement for Seul Ah Lee (Chi Hwan Lee, advisor) Everyone is invited to attend the public presentation beginning at 1:30 pm EST. Title: Development of Vision and Eye Care Device Integrated into Soft Contact Lens Date: July 28, 2022 Time: 1:30 pm EST Location: MJIS 2001 / Zoom* https://purdue-edu.zoom.us/j/98139249622 Committee: Prof. Chi Hwan Lee, Chair; Prof. Young L. Kim; Prof. Hugh Hyowon Lee; Prof. Shin Ae Park Abstract: A considerable amount of research has been done on smart contact lenses, especially as a minimally invasive diagnostic platform and a drug delivery system. The eyes provide rich physiological and broad diagnostic information, making contact lens sensors a promising disease diagnostic tool. A smart contact lens, one such contact lens sensor, can quantify the concentrations of various biomolecules in ocular fluids and physical biomarkers of the eye, such as intraocular pressure. Continuous and non- or minimally invasive contact lens sensors can be directly utilized in a clinical or point-of-care setting. However, smart contact lenses lack practicality for patient use due to the field being relatively new and underdeveloped. Here, we introduce the incorporation of contact lens sensors and their fabrication, sensitivity, power source, and readout mechanisms. The incorporation is to monitor glaucoma and conditions associated with eye health, such as dry eye syndrome and inflammation. The resulting soft contact lens sensors fit seamlessly across different corneal curvatures and thicknesses in human eyes. The lens can also wirelessly capture the intraocular pressure by utilizing the principle of the capacitor and mechanical deformation under ambulatory conditions. Also, we will discuss the colorimetric ocular electrolyte sensors to detect the color change of dry eye disease and inflammation. We assessed the in vitro biocompatibility, ex vivo functionality, and in vivo safety of the soft contact lens sensor. *Seul-Ah Lee is inviting you to a scheduled Zoom meeting. Join Zoom Meeting https://purdue-edu.zoom.us/j/98139249622 Meeting ID: 981 3924 9622 One tap mobile +13126266799,,98139249622# US (Chicago) +16469313860,,98139249622# US Dial by your location +1 312 626 6799 US (Chicago) +1 646 931 3860 US +1 301 715 8592 US (Washington DC) +1 646 558 8656 US (New York) +1 669 444 9171 US +1 669 900 6833 US (San Jose) +1 253 215 8782 US (Tacoma) +1 346 248 7799 US (Houston) Meeting ID: 981 3924 9622 Find your local number: https://purdue-edu.zoom.us/u/aer9n7SaDZ

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BME PhD Preliminary Exam Announcement for Jongcheon Lim (H. Lee and M. Ward, co-advisors)
by May, Sandra M 15 Jul '22

15 Jul '22

BME PhD Preliminary Exam Announcement for Jongcheon Lim (H. Lee and M. Ward, co-advisors) Everyone is invited to attend the public presentation beginning at 9:30 AM EST. Title: Toward advanced neural interfaces for selective vagus nerve stimulation Date: July 28, 2022 Time: 9:30 AM EST Location: MJIS 2001 Thesis Committee members: Dr. Hyowon Lee (major professor), Dr. Mathew Ward (co-advisor), Dr. Chi-Hwan Lee, Dr. Edward Bartlett Abstract: Vagus nerve branches to multiple organs such as heart, stomach, and spleen to regulate their physiological activities. Selective activation of a portion of fibers in the vagus nerve can potentially modulate specific organ activities without off-target effect. Despite recent advancements in microfabrication technology that enable more advanced neural interfaces, current devices for vagus nerve stimulation (VNS) rely on relatively bulky system such as helical cuff electrode, which stimulates entire fascicle indiscriminately. In this presentation, we show three approaches towards selective VNS. First, we investigated VNS using microelectrode with circle and Vicsek fractal shape. Our rat study shows that fractal microelectrode can activate C-fibers in cervical vagus nerve with higher energy efficiency compared to circle microelectrode. Secondly, we developed stretchable and adhesive cuff device for a compliant neural interface for a long-term stability. We designed Y-shaped kirigami thin-film device for stretchability and applied a tissue-adhesive hydrogel to enable tough adhesion of the cuff electrode to the nerve, which can be potentially used to fix the position of microelectrode for a reliable selective stimulation with minimal mechanical mismatch. We plan to test the device in rat model to evaluate the efficacy of the stimulation and potential failure modes. Lastly, we developed a microchannel electrode array device to measure high-quality of single fiber action potential (SFAP) from the teased fibers in abdominal vagal trunk of rat to explore natural patterns selective organ activities which can be used for a fine-tuned selective VNS. Our preliminary results show the potential of measuring C-fiber activities evoked by cervical VNS. In the future, we plan to apply an improved design to increase signal to noise ratio to capture the spontaneous SFAP from the teased nerve fibers.

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Weldon Graduate Program Announcements July 13th, 2022
by Siemers, Tammy R 13 Jul '22

13 Jul '22

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements July 13th, 2022 * Career and Internship Opportunities * Registration open for Fall GRAD 590: Grant Writing "Light" * Postdoc Preview (Sept. 15–17, 2022) * AES Energy Innovation Challenge * Graduate Professional Development Newsletter (July 8) * Cleveland Clinic Morgenthaler Symposium * Aviator's Baseball JULY 15 Fundraiser * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Human Performance Research, environmental health effects and aerospace medicine, Naval Medical Research<https://zintellect.com/Opportunity/Details/NAMRU-Dayton-2022-0010> Postdoctoral Positions * Postdoctoral Fellow, Biomedical Sciences: Accelerating Translation of Biostasis, US Air Force and Defense Health Agency<https://zintellect.com/Opportunity/Details/DHA-JBSA-2022-0012R> * Postdoctoral, Medical Extremity Would Treatment Study, Army Institute of Surgical Research<https://zintellect.com/Opportunity/Details/USAISR-2022-0002> * Postdoctoral Researcher, Biomedical Engineering, Marquette University<https://www.simplyhired.com/job/KBhEO6CV_BWNuSYYzllqSzgpUsMn1s4hGyQD5shDiNZ…> * NPA Website: https://careers.nationalpostdoc.org/jobs/ Full time Positions * Electrical Engineer, Ultrasound, DeepSight Technology<https://www.simplyhired.com/job/P-o8Gf3Lnh_KAcqUQLXKOEMo63diGuZEnR0kdPoox6k…> * R&D Engineer II, Biosense Webster<https://jobs.jnj.com/jobs/2206056209W?lang=en-us&src=JB-10281> * Principal Development Engineer, Resonetics<https://www.simplyhired.com/job/JqJncJnZk9mSqQHzpYMmP1AqFRDxg9Ugh5lPuA97dqM…> * Supervisory Biomedical Engineer, Veterans Health Administration<https://www.usajobs.gov/job/665033000> * Bioengineer, Zymeron<https://www.simplyhired.com/job/rFI6MFxRynlThnmDXQJM5BFLkTzLJLBhAapCcBmL1bq…> * Clinical Engineer, Invoy<https://www.simplyhired.com/job/K1KUe7jldaJnaOenWOM0lHtys-W9O-IyqT60alEStPR…> * MRI Engineer, ViewRay<https://www.simplyhired.com/job/EdSoISI2e-NeKHQnIgLRTZr-5BOkv4HBwN__BjKOo9j…> * Purdue Start-up Job Board<https://purduefoundry.com/jobs?utm_source=Foundry+Mailing+List&utm_campaign…>—Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://careers.actscience.org/>—Association for Clinical and Translational Science * Doc Jobs<https://www.docjobs.com/jobs/list/>—Jobs beyond traditional clinical and academic roles Registration open for Fall GRAD 590: Grant Writing "Light" Registration is open for GRAD 590: Grant Writing "Light" for Fall 2022 Asynchronous Online, 1.0 credit hour, Pass/no pass Grade Mode Weekly quizzes instead of writing assignments Register on MyPurdue: GRAD 59000 - 030, CRN: 24427 "Distance Learning" designation but open to all grad students See the attached flyer for more information Students are welcome to contact Lisa R. Nielsen, PhD with their questions! Postdoc Preview (Sept. 15–17, 2022) * Postdoc Preview is a three-day competitive program that provides selected applicants the opportunity to visit VAI to learn about our postdoc training opportunities, meet one-on-one with our internationally recognized faculty and explore our extensive scientific resources. * VAI will provide transportation, lodging and meals for selected applicants. We also are pleased to offer family care grants for those caring for children or other family members. * Eligibility: Applicants must be current graduate students at U.S. institutions who anticipate beginning a postdoc by January 2024. Individuals who identify as members of underrepresented racial and ethnic groups are strongly encouraged to apply. Preference will be given to U.S. citizens and permanent residents. * Applications are due at 11:59 p.m. ET on July 10. * More information and the application may be found here<https://vari.vai.org/event/postdoc-preview-2022/>. AES Energy Innovation Challenge See attachment The AES Corporation<https://www.aes.com/>, a company specializing in clean power generation and distribution worldwide, is seeking participants for this year's AES Innovation Challenge<https://www.aes.com/innovation-challenge>. In this competition, interdisciplinary teams of graduate students design and present innovative clean energy solutions to real world problems. The first and second place teams are guaranteed $10,000 and $5,000 respectively! In addition to the competition itself, participants will also gain exposure to industry professionals and explore post-graduate opportunities through company presentations, coffee chats, and exclusive free memberships to industry groups such as SEIA<https://seia.org/> and EEI<https://www.eei.org/>. Please refer to the AES flyer for more information about team requirements, the challenge's structure, prizes, networking opportunities, and the competition's prompt and rubric. Graduate Professional Development Newsletter (July 8) Graduate Professional Development Newsletter (July 8)<https://mailimages.purdue.edu/vo/?FileID=a7e12315-eb0c-48c3-b721-a9eab3a400…> Cleveland Clinic Morgenthaler Symposium | Still Time to Apply! See attachment Cleveland Clinic’s Lerner Research Institute is inviting select PhD students for an expenses-paid opportunity to attend and present at the inaugural Morgenthaler Symposium. Join us for two days of networking, talks, posters, and awards with world-renowned faculty and learn about the exciting postdoctoral opportunities at Lerner Research Institute. APPLICATIONS NOW OPEN - Apply Now!<https://ccf.infoready4.com/#competitionDetail/1866217> Applications will be accepted from late-stage STEM PhD students who expect to be looking for a postdoctoral fellowship position in the next few years. Applicants must be enrolled in a United States PhD program. Participants must not have committed to a postdoctoral position before the symposium. Apply by July 15, 2022 at 12pm (Eastern Time). Aviator's Baseball JULY 15 Fundraiser GSO is hosting a fundraiser with the Aviator's baseball team to help fund future GSO events! Purchasing a ticket for the game on July 15th using the Promo Code "ChemE" at checkout will give you $2 off your $10 ticket and a portion of the proceeds will be donated to GSO. Please help promote this event to your friends/family outside the department to help support your GSO. You can purchase your ticket online<https://shop.lafayettebaseball.com/lumberkings-vs-aviators> or at the GSO ticket booth on game day (while supplies last). We suggest purchasing seats in section 111 so we can all sit in a group, although this isn't required. We look forward to seeing you at the game! [https://lh3.googleusercontent.com/jxtrY_S1QMZZh6OTOsvra98orRstAjb7Hyc1iOP01… Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. July 13th BME and IBSc Summer Seminar Presentation: Claudia Benito Alston & Lexi Petrucciani July 18th Coffee with the Dean (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> July 19th Citation Management with Zotero (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> July 19th RCR: Discipline-Specific Training (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> July 19th Suicide Prevention Training July 20th BME and IBSc Summer Seminar Presentation: Om Kolhe & Julia Walsh July 20th Business Meal Etiquette (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> July 27th BME and IBSc Summer Seminar Presentation: Seokkyoon Hong & Sang Hoon Um July 27th Postdoc Grant Writing Lecture: All about National Science Foundation Grants (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> July 27th How to Find and Prepare for Fellowship Applications (Grad) (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> August 3rd BME and IBSc Summer Seminar Presentation: Donghyun Yim & Seul Ah Lee August 10th BME and IBSc Summer Seminar Presentation: Lucy Tecle & Luke Brennan August 17th RCR: Discipline-Specific Training (Grad School)<https://gspd.gosignmeup.com/Public/Course/Browse?viewstate=eyJPcGVuTWFpbkNh…> News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information – specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. – to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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BME PhD Preliminary Exam Announcement for Sang Mok Park (Y. Kim, advisor)
by May, Sandra M 13 Jul '22

13 Jul '22

BME PhD Preliminary Exam Announcement for Sang Mok Park (Y. Kim, advisor) Everyone is invited to attend the public presentation beginning at 3:30pm EST. Title: mHealth blood hemoglobin testing with spectral learning and color accuracy Date: July 27, 2022 Time: 3:30pm EST Location: MJIS 2001 and Zoom Meeting link: https://purdue-edu.zoom.us/j/4572570338 Committee: Prof. Young Kim, Chair; Prof. Craig Goergen; Prof. George Chiu; Prof. Jacqueline Linnes Abstract: Blood hemoglobin (Hgb) testing is one of the most common clinical laboratory tests and has been extensively performed for numerous patient care needs. However, even point-of-care blood Hgb measurements require invasive blood sampling, potentially causing iatrogenic blood loss when repeated tests are needed. The performance of current noninvasive blood Hgb tests is often limited and incomparable to clinical laboratory blood Hgb tests. To overcome these limitations, we have developed a mobile health (mHealth) technology for noninvasive blood Hgb quantification. As an easily accessible sensing site, the inner eyelid is used because of the relatively uniform microvasculature and the absence of melanocytes. Spectral learning and color accuracy (color correction) algorithms are used for reliable blood Hgb assessments. Spectral learning allows mapping from a sparse space (RGB values) to a dense space (multiple wavelengths). In other words, spectral learning virtually transforms the smartphone camera into a spectroscopic imaging device. A tissue-specific color accuracy method extracts true color information of the inner eyelid, independent of smartphone models and ambient light conditions during photo acquisition. An easy-to-use color reference chart with a unique color gamut is designed to be highly sensitive to blood Hgb and peripheral perfusion, permitting single-shot photo acquisition. The spectral learning and color accuracy algorithms combined with spectroscopic blood Hgb modeling enable noninvasive, real-time, and accurate blood Hgb measurements over a wide range of blood Hgb values. Our mHealth blood Hgb testing can be scalable, robust, and sustainable both in resource-limited and homecare settings, facilitating the tempo of clinical translation.

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CCO Job Opportunity for Masters and PhD students
by Siemers, Tammy R 13 Jul '22

13 Jul '22

Good morning, Recently a Purdue Alum that works at WuXi Biologics - Global Solution Provider (HQ located in China) has reached out to us about potential job opportunities that they would like to share to Purdue Chinese Boilermakers, specifically Masters and PhD level students. I've attached 3 job descriptions of open positions that the company is seeking for : Raw Material Function Leader, QC Project Manager, and Analyst, Quality Control. "WuXi Biologics is a global Contract Research, Development and Manufacturing Organization (CRDMO) offering end-to-end solutions that enable partners to discover, develop, and manufacture biologics from concept to commercialization for the benefit of patients worldwide. With over 10,000 skilled employees in China, the United States, Germany, Ireland, and Singapore, WuXi Biologics leverages its technologies and expertise to provide customers with efficient and cost-effective biologics discovery, development and manufacturing solutions. As of the end of 2021, WuXi Biologics has supported over 480 integrated client projects, including nine in commercial manufacturing. For more information, visit us on our website : https://www.wuxibiologics.com/ " It would be greatly appreciated if you can share it with Chinese students who are within your department that is currently in Masters/PhD level.

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BME PhD Preliminary Exam Announcement for Yuhyun Ji (Y. Kim, advisor)
by May, Sandra M 11 Jul '22

11 Jul '22

BME PhD Preliminary Exam Announcement for Yuhyun Ji (Y. Kim, advisor) Everyone is invited to attend the public presentation beginning at 3:00pm. Title: Spectrally driven hyperspectral learning for hemodynamic imaging Date: July 22, 2022 Time: 3:00pm EST Location: Zoom* https://purdue-edu.zoom.us/j/98106894285 Committee: Prof. Young Kim, Chair; Prof. Maria C. Dadarlat Makin; Prof. Stephen B. Hooser; Prof. Yunjie Tong Abstract: Hyperspectral imaging acquires and processes spatial and frequency data, offering rich physical and biological information for a variety of samples. However, due to the concurrent data acquisition in both spatial and frequency domains, conventional hyperspectral imaging systems have the intrinsic limitations of bulky instrumentation and slow data acquisition, often resulting in a tradeoff between spatial and spectral resolution. Here we introduce a learning-based snapshot hyperspectral imaging by hybridizing locally sampled hyperspectral data and a hyperspectral learning algorithm for hypercube recovery. Locally sampled hyperspectral data serve as prior information or physical constraints to incorporate domain-specific modeling into the algorithm. The trained hyperspectral learning algorithm can recover a hypercube from an RGB image without complete hyperspectral scanning of the entire area. We analyze vascular developmental models using learning-based snapshot hyperspectral imaging along with a conventional imaging system for demonstration and validation. Furthermore, hemodynamics of peripheral microcirculation in humans is assessed using a video mode of a smartphone camera with an unprecedentedly high temporal resolution, supported by functional near-infrared spectroscopy measurements of the brain and other peripheral sites. The key advantages of this hybrid approach include the hardware simplicity of using conventional cameras, high temporal resolution when a video is used, no tradeoff between spatial and spectral resolutions, and rich spectral information for a variety of machine learning methods. ______________________________________________________ *ji145(a)purdue.edu<mailto:ji145@purdue.edu> is inviting you to a scheduled Zoom meeting. Topic: Yuhyun Ji - Ph.D. preliminary exam Time: Jul 22, 2022 03:00 PM Indiana (East) Meeting ID: 981 0689 4285 One tap mobile +13017158592,,98106894285# US (Washington DC) +13126266799,,98106894285# US (Chicago) Dial by your location +1 301 715 8592 US (Washington DC) +1 312 626 6799 US (Chicago) +1 646 558 8656 US (New York) +1 253 215 8782 US (Tacoma) +1 346 248 7799 US (Houston) +1 669 900 6833 US (San Jose) Meeting ID: 981 0689 4285 Find your local number: https://purdue-edu.zoom.us/u/adeRrHXCLQ ______________________________________________________

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New Course this Fall: Topics in Cognitive Neuroscience
by Siemers, Tammy R 11 Jul '22

11 Jul '22

Happy Monday! Please find attached a draft syllabus for a new course being taught this fall. For those of you following a BME plan of study, this course will either meet a BME, Life Science or Other Engineering category. The course is live now so feel free to register in the course if you are interested. Tammy Tammy Siemers She/Her Associate Director, Graduate Education Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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Academic Programs Candidate presentations - you are invited
by Gelfand, Johanna K 11 Jul '22

11 Jul '22

We will be interviewing three candidates for our Associate Director of Undergraduate Programs position. All three candidates will be giving a brief presentation, followed by a question and answer session. We would greatly appreciate your attendance at the presentations, and feedback afterward. The three dates are: Tuesday, July 12, Thursday, July 14, and Monday, July 18. All presentation will be from 1:30-2:00 in MJIS 2001. Please attend, give us your feedback (you will be sent a link to a Qualtrics survey), and help us select our next staff/leader. If you have any questions or need additional information, please contact Corey Linkel.

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[Bmeroundtable-list] BME Summer Seminar Announcement: July 13th 9:30-10:30am EST via Zoom
by Rowen, Elizabeth Pearl 11 Jul '22

11 Jul '22

[cid:image001.jpg@01D894FD.11E581C0] BME Summer Seminar Series Wednesday, July 13th, 2022 9:30-10:30AM EST Via Zoom Meeting - link below* Evaluation links: Claudia Benito Alston: https://purdue.ca1.qualtrics.com/jfe/form/SV_eIPB8qSBTdiwCbA Lexi Petrucciani: https://purdue.ca1.qualtrics.com/jfe/form/SV_2hhdmdxcdnMQcpE Fully resorbable 3D printed bone graft for alveolar ridge reconstruction Claudia Benito Alston (L. Solorio, advisor) [https://engineering.purdue.edu/ResourceDB/ResourceFiles/image260837/alter?b…] Abstract: Oral and maxillofacial reconstruction, which is performed on 1.5 million patients worldwide each year, is required for a variety of intraoral and extraoral critically sized bone defects. These defects can originate from accidental injuries such as a car accident, congenital conditions such as cleft palate or diseases such as osteosarcoma which cause maxillofacial malignancies. We aim to generate a 3D printed patient-specific bone graft with controlled release of growth factors. The current standard of care uses particulates of freeze-dried auto- or allografts covered by a titanium mesh, which is then secured in place by screws. This approach is limited by its variability, the length of time the patient is exposed to potential infection during surgery, and although the highly packed allograft signals cells to differentiate along the osteogenic lineage, tight packing often leads to diminished as well as slow bone healing as blood vessels may fail to form. A significant benefit of the current gold-standard of freeze-dried particulate bone allografts are the growth factors (GFs) that are released by the particulates. However, since these are patient derived the GF composition is poorly defined and varies from patient to patient. To address these fallbacks, a 3D printable, biodegradable and implantable device with patient-specific shape and a porous core-cover structure was designed. The cover is porous for cell infiltration and will be loaded with GF releasing microspheres which aim to provide a means for spatial-temporal control of osteoinductive GFs. We hypothesize that the controlled release of microspheres containing growth factors BMP-2 and VEGF as well as FGF encapsulated microbubbles will increase the rate of osteoinduction of a 3D-printed graft. Overall, through a combination of finite element analysis modeling, as well as in vitro and in vivo studies, we aim to generate a patient specific bone graft with an increased rate of osteointegration. Comparing Spheroid And Traditional Cultures Of M. Tuberculosis Using Agent-based Modeling Lexi Petrucciani (E. Pienaar, advisor) [cid:image003.jpg@01D894FD.11E581C0] Abstract: Tuberculosis (TB) continues to be global public health crisis. In 2020, an estimated 1.3 million people died from TB. In vitro methods are commonly used to study host-pathogen interactions in M. tuberculosis (Mtb) infection. There has been a recent interest in developing spheroid models that can represent the TB granuloma environment more closely than the traditional cell culture plate counterparts. Previous work has shown that spheroid models using PBMCs have better bacterial control than traditional culture equivalents, but the cause of these differences is unclear. We use an in silico model to simulate both spheroid and traditional culture to explore whether the difference in Mtb control can be solely due to spatiality. An agent-based model is constructed with Mtb, macrophages (Mφ), CD4+ and CD8+ T cells. Mechanisms include phagocytosis of Mtb by Mφ and activation of Mφ through NFκB and STAT1. Parameters include secretion rates, activation thresholds, and probabilities of killing and movement. After a large parameter sweep using latin hypercube sampling, we select parameter sets that fell within the experimental Mtb counts and sampled ranges around these to enrich sets that represent the entire experimental range. Our results suggest that spatial differences alone can account for the differential Mtb control. Preliminary results suggest that poorer Mtb control in the traditional model is due to lower levels of Mφ activation. The difference in infected Mφ activation is specifically due to STAT1, implying more T cell activation in the spheroid model. But the opposite was seen, with traditional model having more activated T cells. Together, our results suggest that the spatial organization of spheroids allows for more targeted, effective T cell activation. Our model can be used to answer further hypotheses about the dynamics of early Mtb infection in granulomas and to possibly "3-dimensionalize" the results of traditional in vitro models. *Join Zoom Meeting https://purdue-edu.zoom.us/j/92168739019?pwd=cnBOaFBxN3FWVVVTWC8wWWhaekdIdz… Meeting ID: 921 6873 9019 Passcode: biomedical Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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