July 2022 - Bmegradstudents-list

BME PhD Final Examination Announcement for Ethan Biggs (P. Irazoqui, advisor)
by May, Sandra M 05 Jul '22

05 Jul '22

BME PhD Final Examination Announcement for Ethan Biggs (P. Irazoqui, advisor) Everyone is invited to attend the public presentation beginning at 9:00 AM EST. Title: On the Role of, and Intervention in, Oxygen-Conserving Reflexes in Sudden Unexpected Death in Epilepsy Committee members: Dr. Pedro Irazoqui (chair), Dr. Maria Dadarlat, Dr. John Jefferys, Dr. Ben Gaston Date: July 18, 2022 Time: 9:00 AM EST Location: MJIS 2001 and Zoom (https://purdue-edu.zoom.us/j/91042108402?pwd=dE5OM1ZROUk4aEdWMmZFMzR4Skg3UT…) Abstract: Sudden unexpected death in epilepsy (SUDEP) is a fatal complication of epilepsy that kills ~12 of every 10,000 epileptic patients every year. SUDEP has proven difficult to study because it frequently occurs unobserved and cannot be predicted. What limited clinical data exists suggests that SUDEP occurs as a cardiorespiratory collapse immediately following a seizure. In this work, I explore how a group of autonomic reflexes termed collectively as ``oxygen-conserving reflexes (OCRs)'' lead to sudden death when activated during seizures. I also demonstrate multiple physiological parallels between the OCR-mediated deaths that I report and the clinical data on cases of human SUDEP. Additionally, I explore the neural pathway underlying OCRs, identify the carotid body as a potential target for intervention, and demonstrate the efficacy of electroceutical intervention in reducing the mortality risk of OCR activation during seizures. This work seeks to both offer a neural explanation for SUDEP as well as present a promising target and means for potential intervention.

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[Bmeroundtable-list] BME Summer Seminar Announcement: July 6th 9:30-10:30am EST via Zoom
by Rowen, Elizabeth Pearl 05 Jul '22

05 Jul '22

[cid:image001.jpg@01D89049.C5640B30] BME Summer Seminar Series Wednesday, July 6th, 2022 9:30-10:30AM EST Via Zoom Meeting - link below* Evaluation links: Agnes Doszpoly: https://purdue.ca1.qualtrics.com/jfe/form/SV_03woaH29QUpxMdU Zachary Davis: https://purdue.ca1.qualtrics.com/jfe/form/SV_8iW9vF9NzocSnae Calcium-dependent CaMKII Signaling and the Regulation of Actin Filaments of Dendritic Spines in Alzheimer's Disease Agnes Doszpoly (D. Umulis/T. Kinzer-Ursem, advisor) [https://engineering.purdue.edu/ResourceDB/ResourceFiles/image243044/alter?b…] Abstract: Alzheimer's Disease (AD) is a neurodegenerative condition that results in a significant loss of neuronal connection in the hippocampus, as well as overall brain mass from onset of disease. There are currently no effective treatments available for diagnosed patients as AD is the 7th leading cause of death in the USA. One hypothesized underlying condition of AD is the loss of synaptic plasticity, the major mechanism by which neurons function and develop cognitive memories in the hippocampus. Glutamatergic neurons receive excitatory input located at specialized post-synaptic compartments called dendritic spines. Calcium (Ca2+) signaling has been shown to induce dynamic changes in neuronal activity of these dendritic spines. Though many Ca2+ -dependent protein signaling mechanisms have been identified, including that of Calmodulin dependent kinase II (CaMKII), their relative contributions to dendrite morphology via actin polymerization are not well understood. This project aims to investigate how Ca2+/CaMKII signaling controls actin organization and dendritic spine regulation in vivo in a mouse model of AD. It will also aim to optimize a neuronal culture technique for stabilizing dendritic spines prior to imaging. Long-term project goals include developing a super-resolution microscopy to image CaMKIIb/actin interactions and compare data with computational model outputs to produce quantifiable results. Overall, the work aims to identify pharmaceutical targets for developing treatments for AD patients. MRI to determine interface mechanics in soft tissue Zachary Davis (Deva Chan, advisor) [https://engineering.purdue.edu/ResourceDB/ResourceFiles/image260875/alter?b…] Abstract: Articular cartilage is a soft-tissue that covers the ends of bones and lubricates motion within the joints. Defects in the articular cartilage affect almost 1 million Americans per year and can lead to major disabilities such as osteoarthritis. Many of the surgical interventions to repair these defects include implants that contain cells, tissue, healing agents, and other factors to restore biochemical content and mechanical function throughout its depth. It is necessary to confirm that both mechanical function and biochemical content are restored through both benchtop and in vivo tests. For confirming mechanical integration on the benchtop, a pushout test is used to determine the failure force of a suspended repair defect. However, this method cannot be used in vivo since it is destructive. An MRI method called displacement encoding with stimulated echoes (DENSE) has been used to look at strain responses to physiological loads non-invasively. DENSE has been used to look at cartilage mechanics in vivo, in situ, and in vitro. The next stage in developing DENSE for repair applications is to optimize the post-processing to look at the interface, or the area where the repair fill meets with native cartilage. Currently, we are developing an MRI safe loading device to apply cyclic loads within an MRI to be run in sync with the DENSE sequence. We will make gels that contain different stiffness ratio of "native" to "repair" portions to create a mechanical interface similar to ones used in repairs. Image processing pipelines will be tested to determine the optimal pathway to view the interface. Non-invasively determining the strains at an interface can be used to evaluate the mechanical integration not only in cartilage, but in other soft tissues as well. *Join Zoom Meeting https://purdue-edu.zoom.us/j/92168739019?pwd=cnBOaFBxN3FWVVVTWC8wWWhaekdIdz… Meeting ID: 921 6873 9019 Passcode: biomedical Liz Rowen She/Her Graduate Program Assistant Weldon School of Biomedical Engineering Martin C. Jischke Hall of Biomedical Engineering 206 S. Martin Jischke Drive West Lafayette, IN 47907-2032 o: 765-494-1197 [7054E290]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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BME Master's Defense Announcement for Heather George (L. Solorio, advisor)
by May, Sandra M 01 Jul '22

01 Jul '22

BME Master's Defense Announcement for Heather George (L. Solorio, advisor) Everyone is invited to attend the public presentation beginning at 11:30 am. Title: Microtissues Demonstrate Properties of Wound Healing in 3D Date: July 18th, 2022 Time: 11:30 am Location: Zoom Link: https://purdue-edu.zoom.us/j/95847791786 Meeting ID: 958 4779 1786 One tap mobile +16465588656,,95847791786# US (New York) +16469313860,,95847791786# US Dial by your location +1 646 558 8656 US (New York) +1 646 931 3860 US +1 301 715 8592 US (Washington DC) +1 312 626 6799 US (Chicago) +1 669 444 9171 US +1 669 900 6833 US (San Jose) +1 253 215 8782 US (Tacoma) +1 346 248 7799 US (Houston) Meeting ID: 958 4779 1786 Find your local number: https://purdue-edu.zoom.us/u/ayhuE6JAP Advisory Committee: Luis Solorio, chair; Adrian Buganza; Jason Hanna Abstract: An essential stage of repair for a healing wound is the proliferation of cells in the damaged space. Epithelial cells, such as fibroblasts, grow and migrate to aid in construction of new tissue and to close the wound. Current methods of studying fibroblast epithelialization in wound healing include a 2D wound healing assay in which a cell monolayer is scratched, and the cells migrate into the pseudo-wound. However, this lacks the 3D architecture of a physiological wound. Current 3D models of wound healing often rely on the use of a preexisting matrix for structural assistance, however an isolated system of cell growth without requirement of structural aid may gather new insights on intercellular behavior and mechanical properties. We hypothesize that proliferating fibroblasts in 3D on a tessellated SU-8 scaffold creates a more physiologically relevant model for wound healing. This project looks at optimizing fibroblast adhesion and proliferation for 3D microtissue fabrication by altering surface and extracellular matrix (ECM) properties to a SU-8 scaffold. Additionally, we consider the effect of different geometries on cell proliferation and cellular stresses/strains, fibronectin production as pseudo-wounds close, and make comparisons to intercellular cancer behavior. Our results show around a 77% decrease in overall culture time required for the microtissues to reach full confluency. Varying geometries in the tessellated design have revealed structural changes in the actin cytoskeleton formation of fibroblasts, and increased fibronectin production along edges of tensioned cells preparing to "close" the wound. When compared to human breast cancer cells, the cancer cells lack the ability to make critical cell to cell junctions that we observe in fibroblasts, noting the characteristic that cancer is similar to a wound that never heals.

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Clinical Scientist Posting
by Siemers, Tammy R 01 Jul '22

01 Jul '22

This was sent to us directly so I thought I would share. I will be on vacation next week so I won't be sending out any announcements but wanted to make sure you received this. Tammy I wanted to reach out to you about a new Clinical Scientist Posting: https://americas-cookmedical.icims.com/jobs/11027/clinical-scientist/job

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Fw: Graduate Professional Development Newsletter (July 1)
by Siemers, Tammy R 01 Jul '22

01 Jul '22

________________________________ From: The Office of Professional Development <profdev(a)purdue.edu> Sent: Friday, July 1, 2022 1:30 PM To: Siemers, Tammy R <tsiemers(a)purdue.edu> Subject: Graduate Professional Development Newsletter (July 1) Workshops, Funding Opportunities, Important Announcements & More! [https://mailimages.purdue.edu/spacer.gif]<https://maillinks.purdue.edu/t/43383158/1540384810/80194456/0/125061/?72f79…> View as a Web page<https://maillinks.purdue.edu/t/43383158/1540384810/91948469/0/125061/?b44ed…> [https://mailimages.purdue.edu/purdue-grad_opd/final_newsletter_header_grad.…]<https://maillinks.purdue.edu/t/43383158/1540384810/80938003/0/125061/?x=478…> July 1, 2022 [https://mailimages.purdue.edu/purdue-grad_opd/newsletter_buttons.png] [https://mailimages.purdue.edu/purdue-grad_opd/newsletter_buttons_2.png] [https://mailimages.purdue.edu/purdue-grad_opd/newsletter_buttons_3.png] [https://mailimages.purdue.edu/spacer.gif] MUST KNOW InnovatED Research Magazine! Do you want to share your research with readers in more than 45 countries? The Graduate School is now accepting submissions for the 2022 – 2023 edition of InnovatED Graduate Research Magazine. We've increased the award amount! The student author or co-authors selected will receive an award of $250 per accepted manuscript, with the cover story receiving $500. Learn more about InnovatED!<https://maillinks.purdue.edu/t/43383158/1540384810/91339991/0/125061/?x=ffc…> [https://mailimages.purdue.edu/spacer.gif] [https://mailimages.purdue.edu/purdue-grad_opd/newsletter_workshops_-_new_pa…] [https://mailimages.purdue.edu/spacer.gif] July 4 - July 8, 2022 [https://mailimages.purdue.edu/spacer.gif] Attention Grad Students: We are changing the format of the newsletter! Click on a workshop title if you're interested in learning more about the workshop's time, location, and description! [https://mailimages.purdue.edu/spacer.gif] NSF Fellowship Help Sessions (7/6 - In Person)<https://maillinks.purdue.edu/t/43383158/1540384810/91928785/0/125061/?x=1bf…> Time Management (7/6 - Online)<https://maillinks.purdue.edu/t/43383158/1540384810/91928786/0/125061/?x=8b5…> NSF Fellowship Help Sessions (7/7 - In Person)<https://maillinks.purdue.edu/t/43383158/1540384810/91928787/0/125061/?x=624…> [https://mailimages.purdue.edu/spacer.gif] View a complete list of available workshops here!<https://maillinks.purdue.edu/t/43383158/1540384810/78689550/0/125061/?x=e47…> [https://mailimages.purdue.edu/spacer.gif] [https://mailimages.purdue.edu/purdue-grad_opd/newsletter_opportunities_-_ne…] [https://mailimages.purdue.edu/spacer.gif] FUNDING 2022-2023 Vanier Canada Graduate Scholarships Competition The Vanier Canada Graduate Scholarships program is designed to support world-class students pursuing doctoral degrees at Canadian universities. The scholarship awards $50,000 per year for three years. The program is open to both Canadian and international students. Students must be nominated by the Canadian university at which they plan to study. Learn more and register!<https://maillinks.purdue.edu/t/43383158/1540384810/91836969/0/125061/?x=c2b…><https://maillinks.purdue.edu/t/43383158/1540384810/91836969/1/125061/?x=d43…> <https://maillinks.purdue.edu/t/43383158/1540384810/84492542/0/125061/?x=eef…> Purdue Libraries and School of Information Studies: Institute for Information Literacy at Purdue $4,000 Research Grants The Institute will award five $4,000, two-year research grants to information literacy researchers, including current students or post-docs. Applications will be reviewed in July–August 2022. Funding will be awarded beginning in September 2022. Learn more and start your application!<https://maillinks.purdue.edu/t/43383158/1540384810/91636044/0/125061/?x=57a…> American Association for the Advancement of Science (AAAS) and Policy Postdoc Fellowship The AAAS S&T Policy Fellowship (STPF) is now accepting applications for the class of 2023-24! Learn more and start your application!<https://maillinks.purdue.edu/t/43383158/1540384810/91528267/0/125061/?x=890…> U.S citizenship required. Quad Fellowship - STEM masters and PhD students Quad Fellowship is open to STEM masters and PhD students from the US, India, Australia, and Japan. Learn more and start your application!<https://maillinks.purdue.edu/t/43383158/1540384810/91528268/0/125061/?x=6ae…> Deadline is June 30. Outside Fellowships Page Did you know that companies, private foundations, and governmental entities often offer funding opportunities for graduate education? Discover currently active external fellowships by visiting the outside fellowships webpage.<https://maillinks.purdue.edu/t/43383158/1540384810/82772873/0/125061/?x=8ed…> [https://mailimages.purdue.edu/spacer.gif] JOBS University of Hawaii: New Tenure-Track Positions<https://maillinks.purdue.edu/t/43383158/1540384810/91636290/0/125061/?x=471…> Virginia Tech Presidential Postdoc Fellowship Accepting Applications<https://maillinks.purdue.edu/t/43383158/1540384810/91217206/0/125061/?x=91f…> Benchspace Job Board: High-Quality Lab & Research Job Opportunities Benchspace is a regularly updated website that centralizes vetted lab and research jobs into one location. Click here<https://maillinks.purdue.edu/t/43383158/1540384810/87899724/0/125061/?x=009…> to check out their most recent opportunities! [https://mailimages.purdue.edu/spacer.gif] [https://mailimages.purdue.edu/purdue-grad_opd/newsletter_announcements_-_ne…] [https://mailimages.purdue.edu/spacer.gif] AWARDS & RECOGNITION Ag Research Spotlight: Johnathon Knott<https://maillinks.purdue.edu/t/43383158/1540384810/91842971/0/125061/?x=fdc…> Boiler Changemaker: Leanne Nieforth<https://maillinks.purdue.edu/t/43383158/1540384810/91722438/0/125061/?x=a98…> [https://mailimages.purdue.edu/spacer.gif] Nominate a Graduate Student or Postdoc for the Boiler Changemaker Award!<https://maillinks.purdue.edu/t/43383158/1540384810/84372814/0/125061/?x=046…> <https://maillinks.purdue.edu/t/43383158/1540384810/84372814/1/125061/?x=a6d…> [https://mailimages.purdue.edu/spacer.gif] GENERAL ANNOUNCEMENTS Creating Informed Learners in the Classroom (CILC) Symposium The symposium highlights recent work on the integration of information literacy into courses using the informed learning model. The founder of informed learning, Christine Bruce, will give a keynote address. Information literacy researchers, Drew Whitworth and Lorna Dawes, will give invited talks describing how they have used informed learning in their research and teaching. This event will also showcase the collaborative work of librarians and instructors who codesigned student projects that embed information literacy into disciplinary courses at three research universities in the United States (University of Arizona, University of Nebraska, and Purdue University). Learn More<https://maillinks.purdue.edu/t/43383158/1540384810/91890592/0/125061/?x=85f…> & Register Here<https://maillinks.purdue.edu/t/43383158/1540384810/91928334/0/125061/?x=04e…> Virginia Tech Future Faculty Diversity Program The Office for Inclusion and Diversity at Virginia Tech is pleased to announce that the fall 2022 Future Faculty Diversity Program (FFDP) will occur in-person October 2-5, 2022. This year we are primarily seeking candidates in STEM fields. All costs for participants (travel, lodging, meals) will be covered by our office. The Future Faculty Diversity Program is designed to assist departments at Virginia Tech with identifying and recruiting talent from historically underrepresented minority populations such as African Americans, Hispanics/Latinx, American Indian/Alaska Natives, and Pacific Islanders and women in STEM. All candidates should have strong potential for recruitment at Virginia Tech. Learn more and register<https://maillinks.purdue.edu/t/43383158/1540384810/91928335/0/125061/?x=f10…> Boiler Share Symposium The Boiler Share Symposium is a professional development opportunity for Purdue faculty, staff, and graduate students to share expertise, collaborate and learn from each other by presenting and/or attending presentations. The goal of the symposium is to connect faculty, staff, and graduate students with local expertise. Presentations are expected to include topics such as personal and professional development, student well-being, health and wellness, technology, leveraging campus culture, resources, inclusion, crisis intervention trainings and more. RSVP<https://maillinks.purdue.edu/t/43383158/1540384810/91640932/0/125061/?x=dec…> and Submit your proposal!<https://maillinks.purdue.edu/t/43383158/1540384810/91640933/0/125061/?x=dcc…> Fall 2022 Graduate Student EA/EO Sessions The Office of the Vice President for Ethics and Compliance will be offering the Graduate Student Equal Access / Equal Opportunity presentation to interested individuals and programs throughout the week of August 15-19, 2022. This program helps new graduate students become aware of Purdue's policies and procedures relating to harassment and discrimination and their responsibility to comply with such policies to foster a positive and inclusive environment free from discrimination and harassment. Learn more and register!<https://maillinks.purdue.edu/t/43383158/1540384810/86918546/0/125061/?x=b6d…> Fall 2022 Course: Understand Technology Commercialization Before You Start Learn how to navigate the intellectual, financial, leadership, and management processes associated with translating research into tangible products through university-initiated, early-stage commercialization. Learn more about how to prepare for jobs in industry or academia!<https://maillinks.purdue.edu/t/43383158/1540384810/91132905/0/125061/?x=860…> Stanford PRISM Application Now Open! PRISM (Postdoctoral Recruitment Initiative in Science and Medicine) is an opportunity for late-stage graduate students from broadly diverse backgrounds (and all schools/research interests) to explore postdoctoral training at Stanford. PRISM is open to all individuals who are expecting to earn a PhD by the end of May 2024. Learn more about Stanford PRISM and how to apply!<https://maillinks.purdue.edu/t/43383158/1540384810/84492542/1/125061/?x=11d…> [https://mailimages.purdue.edu/spacer.gif] CULTURAL CENTERS Black Cultural Center (BCC) * BCC Hours and Location!<https://maillinks.purdue.edu/t/43383158/1540384810/91636210/0/125061/?x=457…> LGBTQ Center * Summer Queer Grad Coffee Hours are Thursdays from 11:30 am – 12:30 pm in the LGBTQ Center! (Masks are appreciated) * Queer Grad Student Social Programming - Programs and events are currently virtual. Please contact graduate assistant, Lauren Murfree (lmurfree(a)purdue.edu<mailto:lmurfree@purdue.edu>) for more information! * Queer Grad Needs Assessment: Please complete this short assessment <https://maillinks.purdue.edu/t/43383158/1540384810/91605293/0/125061/?x=533…> if you identify as part of the LGBTQIA+ graduate student community at Purdue. * Hours and Location!<https://maillinks.purdue.edu/t/43383158/1540384810/80907646/0/125061/?x=22d…> [https://mailimages.purdue.edu/spacer.gif] MUST KNOW ARTICLES Grad School News: New Course Pairs Graduate Students with Local Nonprofits to Prepare for Diverse Career Pathways and Give Back to the Community<https://maillinks.purdue.edu/t/43383158/1540384810/91604824/0/125061/?x=0a3…> HBR: What the Best Presenters do Differently<https://maillinks.purdue.edu/t/43383158/1540384810/91929905/0/125061/?x=d0e…> [https://mailimages.purdue.edu/spacer.gif] Looking for something? Click here<https://maillinks.purdue.edu/t/43383158/1540384810/83718161/0/125061/?x=932…> to search our newsletter archive! CONNECT WITH US! 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[Bmeroundtable-list] CAUTION: MJIS dock area
by Gelfand, Johanna K 01 Jul '22

01 Jul '22

We have discovered a bee nest on the side of the building (which has been called in to pest control). Please BE AWARE and use caution when outside around the dock area. There have been reports of multiple stings! Stay safe and enjoy the long weekend (once it gets here.) -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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