March 2023 - Bmegradstudents-list

BME PhD Preliminary Exam Announcement for Neal Patel (V. Rayz, advisor)
by May, Sandra M 24 Mar '23

24 Mar '23

BME PhD Preliminary Exam Announcement for Neal Patel (V. Rayz, advisor) Everyone is invited to attend the public presentation beginning at 4:00 PM EST. Title: Characterization of CSF flow using physics-guided enhancement of 4D flow MRI Date and Time: Monday, April 3 at 4:00 PM EST Location: MJIS 2001 and Zoom link: https://iu.zoom.us/j/86147472960 Committee: Vitaliy L. Rayz, Chair; Amy J. Schwichtenberg; Edward J. Delp; Michael Markel Abstract: Cerebrospinal fluid (CSF) plays a diverse role within the skull including cushioning the brain, regulating intracranial pressure, and clearing metabolic wastes via the glymphatic system. Disruptions in CSF flow have long been investigated for hydrocephalus-related diseases. Recently, changes in CSF flow have been implicated in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. It remains difficult to obtain in vivo measurements of CSF flow which would enable further study of disease initiation, progression, and treatment. Three-directional phase-contrast MR imaging (4D flow MRI) has been used to measure CSF velocities within the cerebral ventricles. However, there remain challenges in balancing acquisition time, spatiotemporal resolution, and velocity-to-noise ratio. This is complicated by the low velocities and long relaxation times associated with CSF flow. To address these challenges, we have applied physics-guided neural networks (PGNN) to super-resolve and denoise synthetic 4D flow MRI of CSF flow within the 3rd and 4th ventricles using novel loss functions. These loss functions are specifically designed to ensure that high-resolution estimations of flow fields are physically consistent and temporarily coherent. We apply these PGNN to various test cases including synthetically generated 4D flow MRI in the cerebral ventricles and vasculature, in vitro 4D flow MRI acquired at two resolutions in 3D printed phantoms of the 3rd and 4th ventricles, and in vivo 4D flow MRI in a healthy subject. Lastly, we propose to use these methods to investigate the influence of vasculature changes to CSF flow in the ventricles and associated implications to conditions such as idiopathic normal pressure hydrocephalus.

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Happening Soon: BME Career Connections (virtual)--Dr. Rush Bartlett--Happening Soon
by Siemers, Tammy R 22 Mar '23

22 Mar '23

Just a friendly reminder that this is happening soon. Hoping Dr. Bartlett has great attendance for his time he is dedicating to BME Grad Programs. Tammy From: Siemers, Tammy R Sent: Monday, March 13, 2023 11:39 AM To: bmegradstudents-list(a)ecn.purdue.edu<mailto:bmegradstudents-list@ecn.purdue.edu> Subject: BME Career Connections (virtual)--Dr. Rush Bartlett--Next Week Good Morning, I recently reached out to our alumni in hopes to start offering career information sessions each month. I had great feedback with more than 25 alumni responding. I have scheduled the first of those sessions for March. Please see below for more details in regards to this. Guest: Dr. Rush Bartlett<https://www.linkedin.com/in/rushbartlett/> Dr. Bartlett has a large portfolio of diverse accomplishments including university connections, entrepreneurship and industry relations. I am pretty sure he will have great insight on many career paths. Date: Wednesday, March 22nd Time: 4:00-5:00 pm Join Zoom Meeting https://purdue-edu.zoom.us/j/97626729361?pwd=WUdXcm5uTnlrNUJMcW9iYksyOGJ3QT… Meeting ID: 976 2672 9361 Passcode: 941765 I am really excited to offer these opportunities to you and hope you consider making time to attend. I will send a calendar invite for those of you who utilize this. Tammy Tammy Siemers She/Her Associate Director, Graduate Education Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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Weldon Graduate Program Announcements March 22nd, 2023
by Siemers, Tammy R 22 Mar '23

22 Mar '23

[4,354 Breaking News Photos and Premium High Res Pictures - Getty Images] Weldon Graduate Program Announcements March 22nd, 2023 * Career and Internship Opportunities * Summer Course MSE 597 Lean Manufacturing * Fall Class: CHE 502 (used to be CHE 597) Analytical Approach to Healthcare Delivery * Zuckerman Institute Postdoctoral Fellows in Mind Brain Behavior * Research Engineer & Postdoctoral Fellowship Positions at Stanford University - Human Performance Laboratory * CU Anschutz 2nd Annual Summer Seminar Series: Apply by April 17th * Graduate Professional Development Newsletter (MARCH 17) * Invitation to Princeton's GradFUTURES Forum- annual professional development conference * Boilers Work Internship Program - 2 Weeks Left! * 2nd Women's Quantum Programming Workshop Friday, March 24. Lunch provided! * OIGP Social Justice Seminar * GA Position - Data Reporting * Postdoc Houston Event * Workshops and Deadlines * News from You Career and Internship Opportunities Internship Positions * Engineering and Design Co-op, Johnson and Johnson<https://jobs.jnj.com/en/jobs/2306108964w/engineering-and-design-coop/?src=i…> * Package Development Engineer Co-op, Johnson and Johnson<https://jobs.jnj.com/en/jobs/2306103796w/package-development-engineer-co-op…> * R&D Engineering, Fresenius Medical Care<https://jobs.fmcna.com/job/lawrence/r-and-d-engineering-co-op-15/488/461134…> * Hardware Engineer Co-op, Biomerieux<https://careers.biomerieux.com/jobs/12328253-hardware-engineering-co-op?tm_…> * Biomedical Engineering Intern, GH Labs<https://www.linkedin.com/jobs/view/3523472746/?refId=T%2FwoNFlurgrHF3HhX3%2…> Postdoctoral Positions * Postdoctoral Researcher, Enzyme Engineering, Lawrence Livermore National Lab<https://www.llnl.gov/join-our-team/careers/find-your-job/all/all/3743990001…> * Postdoctoral Fellow, Antibody Design and Engineering, AstraZeneca<https://astrazeneca.wd3.myworkdayjobs.com/Careers/job/US---Gaithersburg---M…> * NPA Website: https://careers.nationalpostdoc.org/jobs/ Full Time Positions * Biomedical Engineer, PhD, Procter & Gamble<https://www.linkedin.com/jobs/view/3277244077/?trackingId=je%2BJyxbNRYSP4EA…> * Biomedical Engineering New Grads, Imaging Project Coordinator, Medpace<https://www.linkedin.com/jobs/view/3426339373/?trackingId=CZB4XP8LTzmPtnlpx…> * Medical Device Project Engineer, Element Materials Technology<https://www.linkedin.com/jobs/view/3524258537/?trackingId=ZMNT5xB5TuWHKS41T…> * Engineer, Human Factors, Eli Lilly<https://www.linkedin.com/jobs/view/3437313387/?trackingId=lo65tZmkQkKXsyClr…> * Metabolic Engineer, Trait Biosciences<https://www.simplyhired.com/job/HQ3u3Yz0EeIFMXCoR8R87fviF-JTRl50PGDKbXE7GfD…> * Staff Engineer, R&D, Johnson & Johnson<https://jobs.jnj.com/en/jobs/2306112199w/staff-engineer-r-d/?src=indeed> * Staff Clinical Engineer, Samsung Research America<https://www.linkedin.com/jobs/view/3491781473/?alternateChannel=search&refI…> * Scientist, Genome Engineering Technology Center, Arc Institute<https://www.simplyhired.com/job/3QLBlbS5PNSiivu_Pa9nqm6SNoYU8fXh6rnbZxNt0WQ…> * Senior Scientist I, Protein Engineering, Solugen<https://www.simplyhired.com/job/kyC-07zSnUsODJsc3c7ESaLenihf-nQK-HJV4sJHkFw…> * Lead Microfluidics Engineer, Chronus Health<https://www.simplyhired.com/job/cyfZHJKN53VHnexOS4YMRnJ44V5xgTHYvVQ1d2GG8EA…> * Human Performance Engineer, KBR<https://careers.kbr.com/us/en/job/KIVKBRUSR2065712EXTERNALENUS/Human-Perfor…> * Clinical Systems Engineer, Dimensional Thinking LLC<https://www.simplyhired.com/job/tb132WkkC3d_eoNhHDRF3lCJmEryCggFOdt_4bWsmG4…> * Senior Research Associate, Greenlight Biosciences<https://www.greenlightbiosciences.com/job-details/?gh_jid=4819370004&gh_src…> * Process Engineer, Siemens Healthineers<https://jobs.siemens.com/jobs/361656?lang=en-us> * Systems Engineer-Electro-Mechanical-Product Development, KMC Systems<https://jobs.smartrecruiters.com/ElbitSystemsOfAmerica/743999893314789-syst…> * Early Device Project Engineering Lead, GSK<https://jobs.gsk.com/en-gb/jobs/365067?lang=en-us&source=Indeed&sourceType=…> * Senior Research and Development Engineer, SPR Therapeutics<https://recruiting.paylocity.com/recruiting/jobs/Details/1609915/SPR-Therap…> * Product Development Engineer II, Smith & Nephew<https://smithnephew.wd5.myworkdayjobs.com/en-US/External/job/Memphis-TN/Pro…> * Tech Staff, MIT Lincoln Laboratory<https://careers.ll.mit.edu/job/Lexington-Tech-Staff-MA-02420/1006309400/?jo…> * Scientist, Biologics Engineering, AstraZeneca<https://astrazeneca.wd3.myworkdayjobs.com/Careers/job/US---Gaithersburg---M…> * Research Assistant, Biomedical Engineering, Vanderbilt University<https://ecsr.fa.us2.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX/j…> * Product Development Engineer, PVD<https://www.simplyhired.com/job/9Xu3ZkILnpsVtk2CszdAvRTWhq6TvEvnTN1f4S1Ahky…> * Senior Scientist, PacBio<https://pacbio.wd1.myworkdayjobs.com/en-US/PacBio-/job/US---California---Sa…> * Biomedical Engineering, Imaging Project Coordinator, Medpace<https://www.linkedin.com/jobs/view/3426339373/?trackingId=UYXuvi8mSMyLTB%2F…> * Senior Engineer, Clinical Research, Samsung<https://www.linkedin.com/jobs/view/3454032367/?trackingId=MVZM6mnVQPC8IJG4c…> * Purdue Start-up Job Board<https://purduefoundry.com/jobs?utm_source=Foundry+Mailing+List&utm_campaign…>-Foundry Start Up Companies Looking to Hire * ACTS Career Center<https://careers.actscience.org/>-Association for Clinical and Translational Science * Academic Careers<https://academiccareers.com/> * Doc Jobs<https://www.docjobs.com/jobs/list/>-Jobs beyond traditional clinical and academic roles Summer Course MSE 597 Lean Manufacturing See Attached This course is normally offered spring semester, but if we get enough interest, we will offer it summer as well. Fall Class: CHE 502 (used to be CHE 597) Analytical Approach to Healthcare Delivery See Attached Zuckerman Institute Postdoctoral Fellows in Mind Brain Behavior The Zuckerman Institute Postdoctoral Fellows program at Columbia University provides an opportunity for talented, early-career scientists to pursue pioneering research into understanding how the brain works <https://zuckermaninstitute.columbia.edu/our-science> - how it evolves, performs, endures and recovers. Fellows will be welcomed into the institute's vibrant intellectual community with broad-ranging collaboration opportunities. The Zuckerman Institute welcomes Fellows from a diversity of disciplines and from groups who have traditionally been underrepresented in science, technology, engineering, and math fields (STEM) to apply. The Zuckerman Institute encourages the Fellows to carry out collaborative research under the mentorship of one or more faculty mentors and will promote their mentorship in an inclusive learning environment. Applications are open now through May 1, 2023 with an expected start by Jan 1, 2024. In person interviews will be held on June 14-15, 2023. As integral members of the Zuckerman Institute community, Fellows will have full access to the institute's cutting-edge equipment, facilities, space and services<https://zuckermaninstitute.columbia.edu/our-science>: including a magnetic resonance imaging facility, a cellular imaging team with advanced microscopy instrumentation, customized molecular and genetic tools, single-cell analysis capabilities, opportunities to partner with the country's strongest concentrations of computational neuroscientists, and more. Fellows will also enjoy the institute's extensive portfolio of scientific programs<https://zuckermaninstitute.columbia.edu/our-programs>, including symposia, seminars, public-outreach opportunities and events with award-winning artists-in-residence. Also available to Fellows are resources for career and professional development and community building. Among them are opportunities to build a network of advisors and connect with PIs and postdocs in other disciplines, special-interest activities (like thematic journal clubs), grant-writing consultation and assistance, trainee advisory resources to navigate both academic and non-academic job markets, and much more. Beyond these institute resources, Fellows will become part of the wider Columbia University community. The fellowship offers a competitive salary and access to the university's postdoctoral housing. Strong preference will be given to early-career applicants who received their Ph.D. less than one year prior to their start date. Learn more and apply here<https://apply.interfolio.com/122352>! Contact: programs(a)zi.columbia.edu<mailto:programs@zi.columbia.edu> Research Engineer & Postdoctoral Fellowship Positions at Stanford University - Human Performance Laboratory Postdoctoral Fellowship A team of faculty at Stanford University, led by Professor Scott Delp<https://nmbl.stanford.edu/people/scott-delp/>, is accepting applications for a Postdoctoral Fellowship in biomechanical engineering and human performance science. Candidates are expected to have a PhD in a related discipline and experience with motion capture technology and biomechanical analysis. Individuals with backgrounds in biomechanics, neuroscience, biomedical informatics, robotics, and computer science are all welcome to apply. The position will be in the Human Performance Lab at Stanford<https://ortho.stanford.edu/humanperformance.html>, which is affiliated with the Neuromuscular Biomechanics Lab<http://nmbl.stanford.edu/> and the Wu Tsai Human Performance Alliance<http://humanperformance.stanford.edu/>. We are searching for outstanding individuals to join our team and develop new methods to measure, simulate, and analyze human movement. Our approach will leverage novel data sources, such as real-world wearable sensors and video, experimental analysis, biomechanical modeling, and state-of-the-art models of neural control. Funding is available to support fellows for two or more years. Fellows will have the opportunity to build an interdisciplinary scientific network, participate in mentoring graduate and undergraduate students, and present their work at international scientific meetings. Candidates must have: * A PhD in engineering, computer science, neuroscience, or related fields * Strong record of publication and excellent communication skills * Experience in biomechanics experiments and modeling Learn more and apply now<https://humanperformance.stanford.edu/news/opening-for-postdoctoral-fellows…> ________________________________ Research Engineer The Wu Tsai Human Performance Alliance<https://humanperformance.stanford.edu/> at Stanford University has established a new position in our Human Performance Laboratory<https://ortho.stanford.edu/humanperformance.html>, which is directed by Professor Scott Delp<https://nmbl.stanford.edu/people/scott-delp/>. The research engineer will work with a talented team of faculty, staff, postdoctoral fellows, and graduate students to advance our understanding of human movement through state-of-the-art experiments and biomechanical simulation. The Research Engineer will conduct world-class research in the Human Performance Lab on projects related to the Human Performance Alliance research priorities, such as revealing the mechanisms of peak performance, preventing sports-related injuries, accelerating rehabilitation from injuries, and building engineering tools and data sets that advance the field. Candidates should have a Ph.D. in Bioengineering, Mechanical Engineering, Computer Science, Kinesiology or related field, including research experience in experimental analysis of human movement and a strong record of scientific publications. Experience with motion capture, wearable sensors, metabolic measurements, strength assessment, data acquisition, EMG recordings, programming in Matlab and/or Python, and excellent communication skills and analytical skills are also required for the position. Learn more and apply now<https://careersearch.stanford.edu/jobs/human-performance-lab-research-engin…> CU Anschutz 2nd Annual Summer Seminar Series: Apply by April 17th We are delighted to announce our 2nd Annual Summer Seminar Series hosted by the Biochemistry and Molecular Genetics (BMG) Department at the University of Colorado Anschutz Medical Campus. The BMG Diversity, Equity & Anti-Racism committee is seeking individuals of racial and ethnic underrepresented backgrounds who are within approximately two years of completing their PhDs and are passionate about pursuing postdoctoral research in academia to share their thesis work with our community and meet potential postdoc mentors. Selected candidates will present their research to the department in a 30 minute seminar, engage in one-on-one meetings with faculty members, connect with current postdocs in the department, dine with department members, and explore both the campus and Denver. Travel and lodging will be fully covered. If you are interested, please use this google form<https://docs.google.com/forms/d/e/1FAIpQLSfKWMIf_ZR6uvkxkzQsj509mqDN8SyZ5fR…> to review the eligibility requirements and submit your CV and talk abstract by April 17th. Applicants will be notified by May 1st. Please contact sarah.vinton(a)cuanschutz.edu<mailto:sarah.vinton@cuanschutz.edu> if you have any questions or technical difficulties. Graduate Professional Development Newsletter (MARCH 17) Graduate Professional Development Newsletter (MARCH 17)<https://mailimages.purdue.edu/vo/?FileID=c15643b5-f156-4ba3-9f45-2e02cbc658…> Invitation to Princeton's GradFUTURES Forum- annual professional development conference [https://gradcareerconsortium.org/photos/Forum_2023_Email_Header_03202023105…] Dear GCC colleagues, On behalf of the GradFUTURES team in Princeton University's Graduate School, I am pleased to invite you, and your graduate students and postdocs to the 2023 GradFUTURES Forum, an annual professional development conference scheduled between March 27-April 1. This forum brings together graduate students, postdocs, graduate alumni, thought leaders and experts across different fields through a lineup of engaging talks, conversations, workshops, resource fair and networking opportunities. The virtual events are open to GCC members, and graduate students, postdocs, faculty, and staff at your universities and institutions. We hope you will share it with your community and encourage participation. We will cover topics addressing innovation and entrepreneurship, research communication, science policy, mental health and wellbeing, diversity equity inclusion and access through professional development, mentorship, leadership, non-linear careers, among others. The topics are relevant to all disciplines. Please click here<https://gradfutures.princeton.edu/VirtualForum2023> for detailed schedule and RSVP for virtual participation (URL- https://gradfutures.princeton.edu/VirtualForum2023) Please don't hesitate to email me (sm4446(a)princeton.edu<mailto:sm4446@princeton.edu>) if you have any questions. Boilers Work Internship Program - 2 Weeks Left! There are only 2 weeks left to submit for the Boilers Work Internship Program! Please share this information with graduate students and faculty in your area! The Boilers Work internship program is open and accepting submissions for the summer of 2023. This internship program provides ten graduate students per year with a stipend to pursue an unpaid summer internship. This year, the stipend award has increased to $7,500! This program is intended to help students garner real-world work experience, refine soft skills, and establish career connections before graduation. The deadline to submit is April 3rd by 11:59 p.m. Awards will be announced on April 14th. More information about this program, as well as rules and requirements, can be found on the website<https://www.purdue.edu/gradschool/professional-development/internships.php>! If you have further questions, please email profdev(a)purdue.edu<mailto:profdev@purdue.edu> Course Announcement: NUR 692: Applied Statistics in Healthcare Mondays 9:30-12:20pm See attached Credits: 3 Course Description: This course surveys statistical methods within the context of healthcare research applications. Emphasis is placed on gaining an intuition for methodological purpose, basic application, and interpretation. Methods covered include descriptive statistics, probability distributions, hypothesis testing, chi-square test, parametric and non-parametric means testing, ANOVA, linear regression, logistic regression, survival analysis, bootstrapping, mixed models, principal components analysis, clustering, and power analysis. Additional topics covered if time permits. Familiarity with basic probability and statistical methods at the undergraduate level is assumed. Lectures and lab will occur in a single period using SPSS software. Assignments follow from methods covered in lecture and lab. 2nd Women's Quantum Programming Workshop Friday, March 24. Lunch provided! See attached RSVP here: purdue.link/iqparc<https://purdue.link/iqparc> (lunch provided!) * Session Chair: Prof. Hadiseh Alaeian (Assistant Professor of Electrical and Computer Engineering and Physics and Astronomy) * 11:00 AM - 11:15 AM: Opening remark by Prof. Mahdi Hosseini (Director of IQPARC, Assistant Professor of Electrical and Computer Engineering and Physics and Astronomy) * 11:15 AM - 11:59 AM Quantum Game Club (Xu (Anderson) Xinzhe and Zirui Zhang, Quantum Game Club Student Leadership) * 11:59 AM - 12:45 PM Lunch Break (Lunch will be provided for in-person attendees). * 12:45 PM - 1:30 PM Dr. Catherine Potts and Dr. Joel Gottlieb (Quantum Data Scientist and Technical Sales Engineer at Quantum Computing Inc.) - Zoom * 1:30 PM - 2:30 PM Mariia Mykhailova (Principal Software Engineer at Microsoft Quantum) - Zoom * 2:30 PM - 3:15 Dr. Ksenia Sosnova, (Senior Physicist, IonQ) * 3:15 PM - 4:00 PM Dr. Sona Najafi (Researcher at IBM Working On Quantum Machine Learning and Quantum Computing) - Zoom * 4:00 PM - 4:15 PM Closing remark by Prof. Alaeian (Assistant Professor of Electrical and Computer Engineering and Physics and Astronomy) OIGP Social Justice Seminar The Office of Interdisciplinary Graduate Programs (OIGP)<http://www.purdue.edu/gradschool/oigp/index.html> cordially invites you to an Interdisciplinary Social Justice Seminar Series: Resilience in Immigrant Youth Experiencing Marginalization: Applying a Social Justice Lens Speaker: Dr. Zoe E. Taylor Associate Professor Department of Human Development and Family Science College of Health and Human Sciences Purdue University Date: Tuesday, March 28, 2023 Time: 12:00 PM Young Hall, Room B-64 Please RSVP<https://purdue.ca1.qualtrics.com/jfe/form/SV_bxZd0EQVt8CDeBw?_ga=2.16913712…> by noon on March 22nd. if you would like to attend the seminar and discussion, lunch will be provided. Visit the Social Justice Seminar Series<https://www.purdue.edu/gradschool/oigp/events/social-justice-seminar-22-23.…> to see other upcoming events that you may be interested in joining. GA Position - Data Reporting See attached Another graduate assistant opening in the College to begin Summer 2023 or Fall 2023 to assist with data reporting. See attached announcement for details and link to apply. Apply by April 7th. Postdoc Houston All are invited to this free, virtual Postdoc Houston recruitment event on May 18th at 11 AM Central! MD Anderson Cancer Center<https://www.linkedin.com/company/mdandersoncancercenter/>, Baylor College of Medicine<https://www.linkedin.com/company/baylor-college-of-medicine/>, The University of Texas Health Science Center at Houston (UTHealth Houston)<https://www.linkedin.com/company/uthealth-houston/>, and Houston Methodist<https://www.linkedin.com/company/houston-methodist/> are teaming up to introduce prospective postdocs to Houston, our institutions, and the incredible opportunities that exist at the Texas Medical Center<https://www.linkedin.com/company/texas-medical-center/>. This event is open to anyone who is interested in learning about postdoc opportunities. Details and registration are here -- https://lnkd.in/gvqxHE9v. https://www.postdochouston.org/ Workshops and Deadlines Here are some upcoming workshops and deadlines more detailed information about the workshops will be sent out separately closer to the event. March 22nd Debt Management (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) March 22nd Ask a Postdoc Panel (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) March 22nd Writer's Room 3 - 5 pm (Sign Up<https://purdue.mywconline.com/register.php?authentication=YES&email2=eprowe…>) March 22nd Deadline to RSVP to OIGP Seminar: Resilience in Immigrant Youth (RSVP<https://purdue.ca1.qualtrics.com/jfe/form/SV_bxZd0EQVt8CDeBw?_ga=2.16913712…>) March 23rd Let's Talk Taxes (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) March 23rd Using Data to Tell a Story (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) March 23rd Preparing an Effective Lecture (Teaching) (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) March 24th LinkedIn (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) March 24th 2nd Women's Quantum Programming Workshop (RSVP<https://boilerlink.purdue.edu/event/8927507>) March 27th Authorship and Publishing (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) Mar. 27 - Apr. 1 Princeton's GradFUTURES Forum: Annual Professional Development Conference (Register Here<https://gradfutures.princeton.edu/VirtualForum2023>) March 28th Seminar: The Heights and Pitfalls of Resilience: A Social Justice Perspective (OIGP<https://www.purdue.edu/gradschool/oigp/events/social-justice-seminar-22-23.…>) March 28th OIGP Seminar: Resilience in Immigrant Youth Experiencing Marginalization (RSVP<https://purdue.ca1.qualtrics.com/jfe/form/SV_bxZd0EQVt8CDeBw?_ga=2.16913712…>) March 29th Writer's Room 3 - 5 pm (Sign Up<https://purdue.mywconline.com/register.php?authentication=YES&email2=eprowe…>) March 30th Inaugural BIPOC in Biotech event in Chicago (Register Here<https://www.eventbrite.com/e/techchicagos-bipoc-in-biotech-tickets-52006152…>) March 31st Deadline to submit application for BME Graduate Research Symposium (Apply Here<https://forms.gle/eT8C8Jkd1cmDbut98>) April 3rd Submission deadline for Boilers Work internship program (Grad School<https://www.purdue.edu/gradschool/professional-development/internships.php>) April 4th Coffee with the Dean (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) April 5th How to Avoid Common Fellowship Application Mistakes (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) April 5th How to Deliver a Winning Presentation (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) April 5th Writer's Room 3 - 5 pm (Sign Up<https://purdue.mywconline.com/register.php?authentication=YES&email2=eprowe…>) April 7th Deadline to apply for Engineering Data Reporting Grad Assistant (Apply Here<https://purdue.ca1.qualtrics.com/jfe/form/SV_2isfuNNMRduJFLE>) April 11th 3MT Competition - in person (Grad School<https://www.purdue.edu/gradschool/professional-development/competitions/3mt…>) April 12th Writer's Room 3 - 5 pm (Sign Up<https://purdue.mywconline.com/register.php?authentication=YES&email2=eprowe…>) April 13th Debt Management (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) April 14th Boilers Work internship program awards announced (Grad School<https://www.purdue.edu/gradschool/professional-development/internships.php>) April 17th Deadline to apply for CU Anschutz 2nd Annual Summer Seminar Series (Apply Here<https://docs.google.com/forms/d/e/1FAIpQLSfKWMIf_ZR6uvkxkzQsj509mqDN8SyZ5fR…>) April 18th Fellowship Office Hour for Grad Students and Postdocs (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) April 18th Credit Cards and Credit Scores (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) April 18th Business Meal Etiquette (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) April 19th Copyrights: An Overview for Scholars (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) April 19th Elevator Pitch Workshop (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) April 19th Writer's Room 3 - 5 pm (Sign Up<https://purdue.mywconline.com/register.php?authentication=YES&email2=eprowe…>) April 19th 2023 Inaugural Tyler Symposium: Honoring Leaders in Pharmaceutical Sciences (Register<https://purdue.ca1.qualtrics.com/jfe/form/SV_0THM10ahPguLFbM>) April 20th Credit cards and Credit Scores (Grad School<https://gspd.gosignmeup.com/public/course/browse?viewstate=eyJPcGVuTWFpbkNh…>) April 24th-25th Facilitating Entering Mentoring Workshop (CIMER<https://sites.google.com/wisc.edu/facilitatingenteringmentoring/home?pli=1>) April 26th Writer's Room 3 - 5 pm (Sign Up<https://purdue.mywconline.com/register.php?authentication=YES&email2=eprowe…>) May 3rd OIGP Annual Spring Reception (OIGP<https://www.purdue.edu/gradschool/oigp/events/spring-reception/index.html>) May 6th Deadline to pass the prelim in order for it to count as Spring 2023 May 11th 2023 BME GSA Graduate Research Symposium May 22nd Deadline to apply for Trailblazers in Engineering (TBE) Workshop (Apply Here<https://engineering.purdue.edu/Engr/Trailblazers/?utm_source=delivra&utm_me…>) May 24th-25th Facilitating Entering Mentoring Workshop (CIMER<https://sites.google.com/wisc.edu/facilitatingenteringmentoring/home?pli=1>) July 24th-25th Facilitating Entering Mentoring Workshop (CIMER<https://sites.google.com/wisc.edu/facilitatingenteringmentoring/home?pli=1>) News from You Please inform Tammy of honors, awards, or other accolades (to include having a paper published) you receive so that the Weldon School may recognize your accomplishments. Send the complete information - specific title and nature of the award, name of conference or event at which award was given, date of said event, photograph if available, etc. - to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu>. Tammy Siemers She/Her Associate Director, Graduate Education Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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REMINDER--Tomorrow: BME Career Connections (virtual)--Dr. Rush Bartlett--Next Week
by Siemers, Tammy R 21 Mar '23

21 Mar '23

Good Afternoon- This is just a friendly reminder in regards to our Career Connection talk tomorrow from one of our alumni. He brings a wealth of knowledge from various backgrounds so I am sure he will have much insight to share. Tammy From: Siemers, Tammy R Sent: Monday, March 13, 2023 11:39 AM To: bmegradstudents-list(a)ecn.purdue.edu Subject: BME Career Connections (virtual)--Dr. Rush Bartlett--Next Week Good Morning, I recently reached out to our alumni in hopes to start offering career information sessions each month. I had great feedback with more than 25 alumni responding. I have scheduled the first of those sessions for March. Please see below for more details in regards to this. Guest: Dr. Rush Bartlett<https://www.linkedin.com/in/rushbartlett/> Dr. Bartlett has a large portfolio of diverse accomplishments including university connections, entrepreneurship and industry relations. I am pretty sure he will have great insight on many career paths. Date: Wednesday, March 22nd Time: 4:00-5:00 pm Join Zoom Meeting https://purdue-edu.zoom.us/j/97626729361?pwd=WUdXcm5uTnlrNUJMcW9iYksyOGJ3QT… Meeting ID: 976 2672 9361 Passcode: 941765 I am really excited to offer these opportunities to you and hope you consider making time to attend. I will send a calendar invite for those of you who utilize this. Tammy Tammy Siemers She/Her Associate Director, Graduate Education Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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[Bmeroundtable-list] FW: Shah Family Global Innovation Lab invites you to the 2023 Innovation for International Development (I2D) Expo - 4/11 (Tue)
by Gelfand, Johanna K 21 Mar '23

21 Mar '23

[cid:image001.png@01D95BFB.DF5AF7A0]<https://engineering.purdue.edu/GEP/ShahLab/Expo2023/Expo_2023> Poster Registration: https://docs.google.com/forms/d/147LyUnxNx-V4FDXTnYraxdaQYvC-LIXx-F0TG6lddC… Seed Grant Showcase Registration: https://docs.google.com/forms/d/1prg58B2P3ZshGC9lr1Waj7JvEMauvTUybp607XlfKe… Keynote Address, Awards, and Reception: https://docs.google.com/forms/d/1psbNzxkc7vLvHB5WWAo34PbilAUKD6GPInun5ckf_K… ----------------------------- George Chiu (he/him/his) Purdue University +1-765-494-2688 gchiu(a)purdue.edu<mailto:gchiu@purdue.edu> -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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IBSC-BME PhD Defense Announcement for Edmond A. Rogers (R. Shi, advisor)
by May, Sandra M 21 Mar '23

21 Mar '23

IBSC-BME PhD Defense Announcement for Edmond A. Rogers (R. Shi, advisor) Everyone is invited to attend the public presentation beginning at 10:30 AM. Title of Thesis Research: Elucidating pathological correlations between Traumatic Brain Injury and Alzheimer's Disease Committee: Major Professor: Dr. Riyi Shi, M.D., Ph.D. Dr. Fang Huang, Ph.D. Dr. Joesph Rispoli, Ph.D. Dr. GuangJun Zhang, M.D., Ph.D. Date/Time: April 5th at 10:30 AM - 12:30 PM Location: https://purdue-edu.zoom.us/j/97333625618 Abstract: Traumatic Brain Injuries (TBI) are a major cause of disability and death in the United States. One of the greatest consequences of the disease is the resulting long-term damage, especially in milder injuries where the damage is initially subclinical and thus lacking acutely observable manifestations that over time can compound significantly. Among these chronic issues, Alzheimer's Disease (AD) could be the most serious. While multiple studies demonstrate an increased likelihood of developing neurodegenerative diseases in response to TBI, the underlying mechanisms remain undefined and limited treatment options are currently available. Multiple hypotheses have been postulated based on various animal and clinical models, contributing a great deal to our current knowledge base and implicating several related-targets of interest (i.g. oxidative stress, inflammation, proteostasis-disruptions). While extremely valuable, these in vivo examinations are physiologically and ethically complex: there is currently no model capable of separating and visualizing TBI-induced sub-cellular damage in the moments immediately following injury, and the associated long-term changes. Further, no mechanistic study has been performed to link mechanical-trauma independently with neurodegeneration initiation via protein aggregation. It is clear that additional investigative tools are needed to rectify these intricate issues, and while in vitro methodologies generally offer the type of resolution required, no such model replicates these phenomena. Therefore, we introduce the "TBI-on-a-chip" in vitro concussive model, with a series of concomitant targeted-experiments to address this urgent, currently unmet need. Utilizing TBI-on-a-chip, we directly observe evidence of impact-induced functional and biochemical consequences, while isolating oxidative stress as a key, contributing component.

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[Bmeroundtable-list] BME Monday Roundtable - March 20, 2023
by Gelfand, Johanna K 20 Mar '23

20 Mar '23

[cid:image003.jpg@01D95B11.3D9F9320] BME MONDAY ROUNDTABLE March 20, 2023 DEPUTY HEAD'S NOTE Dear all, Welcome back! I hope you had a wonderful Spring Break wherever you were with family, friends, and colleagues. It was good to take some time off as we all deserved it. I hope you kept warm. We got some white stuff on the ground over the past weekend here in West Lafayette. I had an emotional rollercoaster watching this season of Purdue Men's basketball coming to an end. They won the Big Ten Conference tournament at the beginning of the break and lost to a No. 16-seed on Thursday. I was in town the whole break and was with my students at the Bryant as the loss unfolded. Disbelief was written all over many diner's faces that night at the Bryant. Business as usual. Now we have the second half of the spring semester ahead of us and have another season starting this fall to look forward to. Mike Heinz and Tami Kinzer-Ursem presented a great amount of detail on the newly formatted BME PhD qualifier in the recent BME faculty meeting (3/10). I believe this is a good measure we are taking to better control the quality of our PhD students and give all of us a formal channel to proactively mentor them. We will have some fun in April and May together with our students. As far as the Indianapolis faculty rehoming process goes, we are all set with the two Primary Committee meetings on March 28th and April 4th. We want to have a fair and transparent review process. We want to welcome those who are excellent in their academic careers and who desire to help our school become better with the integration. I know Jo has put the BRAG Session announcement at the top of next block. I still want to use this opportunity to give a shout-out to Kaisa Ejendal, Linlin Li, and Monisha Elumalai, the research scientist organizers. I also want to personally thank Taimoor Qazi and the others who have contributed to BRAG. The following may be an incomplete list * Leo Green: What I wish I knew as a senior postdoc * Deva Chan and Craig Goergen: The needle in the haystack: How to identify, apply for and get the tenure track job of your dreams * Loran Solorio: Breaking into Industry R&D: Tips from a former postdoc * Young Kim: The good, the bad, and the ugly of clinical research as a biomedical engineer * Andrew Brightman: Responsive mentoring for responsible research UPCOMING IMPORTANT DATES Week of March 20 Mon., March 20: BRAG Session (for BME postdocs, visiting scientists and research staff), 11:45 a.m. - 1:00 p.m., MJIS 2001. Meet with one of BME's newest faculty members, Assistant Professor Taimoor Qazi. Taimoor will talk about finding and applying for jobs in academia and what to expect as a new faculty member and title is "Transitioning from a postdoc to a faculty position - what it's like on the other side". Lunch will be provided. Please RSVP via the Microsoft office invitation (sent separately) or directly to kejendal(a)purdue.edu<mailto:kejendal@purdue.edu> so we can order lunches. Please indicate any dietary restrictions. Mon., March 20: Center for Diabetes and Metabolic Diseases Research Seminar, 12:00 p.m., via Zoom. Renata Pereira Alambert, Assistant Professor of Internal Medicine - Endocrinology and Metabolism, University of Iowa, will present "Novel Players in Brown Adipose Tissue Regulation of Metabolic Health." Zoom link: https://iu.zoom.us/s/87501979533 Tues., March 21: BME PhD Defense Announcement for Rashed Almousa (D. Xie and K. Park, Co-Chairs), 9:00 a.m. via Zoom. Title of presentation: "Surface Modification of PVC/PU for Enhanced Biofouling Resistance." Tues., March 21: Structural Engineering Seminar, 4:30 p.m., HAMP 1144. Professor Ayhan Irfanoglu, Associate Head of Lyles School of Civil Engineering will present a seminar entitled "First Impressions of the February 2023 Earthquake Disaster in Turkey." Abstract: A sequence of earthquakes on 6 February 2023 struck the south-southeastern part of Turkey, bordering Syria. Ground motions recorded near the source fault zone are among the most intense to struck urban built environment. Several cities, large and small, new and historic, were devastated. Just in Turkey, the disaster zone includes over 12 million people in 11 provinces. It is reported that more than fifty thousand lives were lost in Turkey and Syria in collapsed buildings. Observations made during a rapid reconnaissance, February 15-19, supported by the Earthquake Engineering Research Institute will be shared. Reflections will be made on the current practice of earthquake engineering. Wed., March 22: BME Seminar Series, 9:30 a.m., MJIS 1001 and via Zoom. Dr. Nicole Adams, Clinical Associate Professor and RWJF Nursing and Health Policy Fellow, Purdue University School of Nursing. Title of presentation: "The meaningful use of technology in healthcare: Different languages, different goals." Wed., March 22: Seminar for Neurotrauma and Diseases, 4:00 p.m., via Zoom. Brad Duerstock, PhD, Professor of Practice for the Weldon School of Biomedical Engineering at Purdue will present "Detection of autonomic dysreflexia in persons with spinal cord injury using noninvasive sensors." The Seminar for Neurotrauma and Diseases is organized by the Center for Paralysis Research and is sponsored by Plexon, the Purdue Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. Zoom link: https://bit.ly/3HsTf5R Wed., March 23: Seminars in Hearing Research, 10:30 a.m., LYLE 1150 and via Zoom. Leroy Medrano, B.S. COHC, SLHA will present "Cortical measures of cognitive engagement during speech processing." Cochlear Implants (CI) are one of the most successful medical prostheses in the world. Yet, it is still unclear as to why there is substantial variability in speech recognition performance among CI users. Attempts to better understand this enigma have used behavioral tasks to examine cognitive ability in the domain of executive function in adult CI users. Zoom link: https://purdue-edu.zoom.us/j/4326340458 Upcoming important deadlines and info. Mon., March 27: Special BME Seminar, 9:30 a.m., MJIS 2001. Joseph R. Leach, MD, PhD, Assistant Professor in Residence, Department of Radiology and Biomedical Engineering at the University of California, San Francisco, will present "Abdominal Aortic Aneurysm Assessment - Moving Beyond Measurement." Thurs., March 30: BME PhD Defense Announcement for Katherine Leyba (Dr. Craig Goergen, Advisor), 10:00 a.m., MJIS 2001 and via Zoom. Research title: Optical and Acoustic-based Imaging Methods for Quantification of Oxygenation and Strain in Murine Cardiovascular Disease Models. Thurs., March 30-Fri., March 31: 18th Annual Garnet E. Peck Symposium, Purdue Department of Industrial and Physical Pharmacy, Stewart Center and Purdue Memorial Union. 1-1/2 day symposium to showcase advances in pharmaceutical manufacturing, with sessions focusing on biologics and small molecules. Presentations include the latest developments on excipients and continuous manufacturing, novel processing technologies as well as a poster session and 3-minute student thesis competition. Registration is now open: http://www.purdue.edu/conferences/Peck2023 . There is a $15 registration fee. See attached flyer. Mon. Apr. 3 - Fri., Apr. 7: Grad Student Appreciation Week. Our grad students are superheroes! Let us show you how much we appreciate you! Monday - Not all heroes wear capes! Grab a token of appreciation, 3-4:00 p.m.; Tuesday - Get your POW! back with a snack, 10-11:00 a.m.; Wednesday - A SOUP-er Peer Mentoring Lunch, 11am-1pm; Thursday - Super-charge your morning! 9:30-10:30 a.m.; Friday - Grab a "Frozone" Treat! 3-4:00 p.m. See flyer for details. Mon., April 3: BME PhD Defense Announcement for Anastasiia Vasiukhina (L. Solorio, advisor), 10:00 a.m., MJIS 2001 or via Zoom. Title of presentation: Small-scale Technologies for Enhanced Diagnostics and Therapeutics. Tues., April 4: BME PhD Defense Announcement for Jonathan Cody (E. Pienaar, advisor), 1:30 p.m., DLR 131 and via Zoom. Title of presentation: "Mathematical Modeling of Interluekin-15 Therapy for Human Immunodeficiency Virus." Wed., Apr. 5: Frontiers in Biophysics Seminar Series, 1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present "Mechanical Stability of Microtubules." Thurs., Apr. 6: BME Faculty and Staff Town Hall, 1:00-2:00 p.m., MJIS 2001. Arvind Raman, the next dean of Purdue's College of Engineering starting April 1, will begin hosting town halls for Purdue Engineering's academic units and listening sessions for faculty and staff in April and May. The main goal for the town halls is to seek input and advice on the College's priorities for the coming years. Faculty and staff are invited to attend the town hall of their respective academic unit. Registration is not required for the town halls. A zoom link will be provided for each unit's town hall; they will not be recorded. Thurs., Apr. 6: BME Master's Defense Announcement for Sydney Clark (C. Goergen, advisor), 9:00 a.m., MJIS 2001 or via Zoom. Title: Cardiovascular Applications of Non-Invasive Imaging. Fri., May 12-Sat., May 13: Inaugural Krannert Cardiovascular Research Center Biennial, sponsored by the Indiana University School of Medicine at the JW Marriott and Eiteljorg Museum, Indianapolis, IN. Krannert is conducting a nationally recognized CME event May 12-13 (Fri-Sat) on Myocardial Infarction & Reperfusion Injury. We cordially invite you to join us if possible. We have a strong line up of speakers on the topic who are renowned for their decades of contributions to the field. We are hoping for an event that would capture almost 50 years of activity in the field of ischemia/reperfusion and place it in a context to chart the course forward with the goal of improving care for heart attack patients. This is a great opportunity to meet thought leaders, engage in transformative science, and hopefully be part of a journey to advance CV research. For Program Agenda & Registration, please follow the link: https://medicine.iu.edu/institutes/cardiovascular/research/biennial Thurs., May 25: Application Deadline for Trailblazers in Engineering workshop, to be held on the Purdue campus July 25-26. Trailblazers in Engineering (TBE) is a multi-day workshop focused on preparing future outstanding engineering scholars for future engineering faculty careers who are also committed to increase the success of underrepresented communities of engineers. Trailblazers in Engineering Fellows are selected not only for their outstanding scholarly achievements but also for their potential impact in expanding representation and diversity in engineering. See attached flyer for application instructions. Committee Updates Graduate Office Update Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001). Full schedule below. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Details below. BMEGSA General Body Meetings - All BME graduate students are welcome, and encouraged to attend! Upcoming meetings: Friday, March 31st 12:30PM-1:30PM Thursday, April 20th 3:30PM-4:30PM All meetings are held in MJIS 2001 in person only. Graduate Admissions Update Fall 2022 (Fall 2023 Admit Term) BME Graduate Admissions DateDATE Activity Mar 31 Due: All PhD students to be decisioned as either admit, deny or hold April 15 Graduate applicant acceptance deadline Research Update Participants needed for a Motor Function Study, "Development of a Diagnostic System for Assessment of Motor Impairment," IRB# IRB-2022-1299. See below for details. Resources and further information BME PhD Defense Announcement for Rashed Almousa (D. Xie and K. Park, Co-Chairs), Tues., March 21, 9:00 a.m. via Zoom. Title of presentation: "Surface Modification of PVC/PU for Enhanced Biofouling Resistance." Thesis Committee members: Prof. Dong Xie (Co-Chair), Prof. Kinam Park (Co-Chair), Prof. Jiliang Li, Prof. Sungsoo Na Abstract: Medical devices are at risk of biofouling within seconds after implantation, which can lead to thrombus formation and bacterial contamination. These issues can negatively impact the performance and reliability of the device. Poly(vinyl chloride) (PVC) and polyurethane (PU) are popular synthetic polymers used in biomedical applications, but their hydrophobic nature makes them susceptible to biofouling. To improve their biocompatibility, their surfaces must be modified to be antifouling. However, achieving a thoroughly coated surface through homogeneous activation and effective modification with antifouling polymers remains a challenge, despite recent advancements in polymer surface modification. In this dissertation, we modified the surfaces of medical-grade PVC and PU using hydrophilic and biocompatible polymer brushes via wet chemistry approaches in an aqueous medium. Specifically, we activated the PVC surface with amino groups and then modified it with either modified or synthesized hydrophilic polymers end-capped with reactive groups. Additionally, we coupled a functionalized surface initiator to the activated PVC surface to allow the grafting of different hydrophilic polymers via conventional in situ free-radical polymerization. We followed a similar process to activate the PU surface with amino groups and then coupled a co-initiator derivative to allow the grafting of different hydrophilic polymers via conventional in situ free radical polymerization as a redox initiation system. All the modified surfaces of PVC and PU have exhibited a significant increase in wettability, as well as extremely effective antifouling effects against cell and bacterial adhesion. Overall, the findings of this work demonstrate the applicability of wet chemistry surface modification for PVC- or PU-based medical devices and supplies in biofouling-resistant applications. Zoom Link: https://purdue-edu.zoom.us/j/99594936275 BME Seminar Series, Wed., March 22, 9:30 a.m., MJIS 1001 and via Zoom. Dr. Nicole Adams, Clinical Associate Professor and RWJF Nursing and Health Policy Fellow, Purdue University School of Nursing. Title of presentation: "The meaningful use of technology in healthcare: Different languages, different goals." Abstract: Healthcare is a huge sector of our economy and touches all of our lives. It is also a place where efficiency, process improvement, and advanced technology can improve outcomes, both health and financial. However, providing care to a patient and advancing new technologies do not always align. This can be due to a misalignment of the language of medicine and the language of engineering, or a misalignment of the goals of medicine and the goals of engineering. In this seminar, Dr. Adams will talk about some of her active and developing projects which incorporate new technology in healthcare applications. She will focus on the alignment of clinical goals with technological advances and a mutually beneficial relationship between nursing and engineering on a project. Biography: Dr. Adams conducts research focused on community responses and collaborations addressing the opioid crisis, substance use, and mental health. As an associate member of the Regenstrief Center for Healthcare Engineering (RCHE), she works closely with engineers to develop innovative tools for use by communities and organizations. Dr. Adams applies concepts from Systems Thinking and Complex Adaptive Models to evaluate community resources and build collaboration between entities. She also focuses on including human factors and end-user perspectives into new technologies to improve healthcare delivery and organizational efficiency. Dr. Adams has created educational videos, presentations, and modules about substance use and recovery that are approachable to those in academia as well as the general public. Her previous research has included topics related to health economics, hospital payment systems, and value-based purchasing. ~ BME Host: Young Kim ~ Zoom link: https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09 NOTE: Students registered for the seminar are expected to attend in-person. Special BME Seminar, Mon., March 27, 9:30 a.m., MJIS 2001. Joseph R. Leach, MD, PhD, Assistant Professor in Residence, Department of Radiology and Biomedical Engineering at the University of California, San Francisco, will present "Abdominal Aortic Aneurysm Assessment - Moving Beyond Measurement." Abstract: Abdominal aortic aneurysms (AAA) have a pooled global prevalence of 4.8% and are most common in men 65 years or older. Small AAAs (<4 cm) are commonly asymptomatic and pose little danger, while larger AAAs have a significant risk of fatal rupture that increases with increasing aneurysm diameter. Despite decades of research elucidating the histologic and biochemical features of AAA evolution, clinicians have relatively little capacity to predict or modify AAA progression in practice - we are lacking an understanding of AAA progression on a patient-specific basis, informed by factors readily assessed during periodic imaging-based surveillance. In his talk, Dr Leach will review the current state-of-the-art in clinical AAA evaluation, and present ongoing research on a comprehensive AAA assessment in which aneurysm measurement is augmented by advanced imaging-based measures of aneurysm inflammation, biomechanics, and higher-order morphologic features. Bio: Joseph R Leach, MD PhD is an Assistant Professor in Residence in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Leach obtained his PhD in Bioengineering in 2009 from University of California -Berkeley, and completed medical school, residency, and a fellowship in abdominal imaging at UCSF prior to joining the faculty in 2018. Dr. Leach has broad clinical and research interests in vascular disease and applies advanced imaging techniques and imaging-based biomechanical modeling to better understand factors influencing disease initiation, progression, and patient outcomes. Outside of the hospital, Dr. Leach enjoys cooking for his wife, Joyce and their cats Jacks and Nigel, and is a lifelong musician and terrible dancer. ~BME Host: Vitaliy Rayz~ BME PhD Defense Announcement for Katherine Leyba, Thurs., March 30, 10:00 a.m., MJIS 2001 and via Zoom. Research title: Optical and Acoustic-based Imaging Methods for Quantification of Oxygenation and Strain in Murine Cardiovascular Disease Models. Thesis Committee members: Dr. Craig Goergen (Chair), Dr. Fang Huang, Dr. Charles Bouman, Dr. Pierre Sicard Abstract: Cardiovascular disease (CVD) is the leading cause of death worldwide and is expected to increase direct medical costs in the U.S. to $749 billion by the year 2035. Diagnosis of CVD through imaging techniques can improve our understanding of CVD progression and its associated risks through visualization of anatomical features and biological constituents. Non-invasive imaging relies on optimal image quality for visualization of such tissue structures that can be difficult to identify and segment. While various imaging modalities are used to determine tissue characteristics, many lack the spatial resolution that optics-based imaging can provide, which can assess hemodynamic parameters in preclinical models of ischemic disease. Acoustic-based imaging can complement optics-based imaging by providing anatomical and location-specific information of tissues with greater penetration depth. Even with all the advancements in imaging technology, however, limitations still exist in non-invasively, efficiently, and accurately capturing biologically relevant information with adequate spatial and temporal resolution. Furthermore, reproducible feature extraction is difficult due to a lack of standardization in the field, making it difficult to implement when image quality varies. In this work, we implement spatial frequency domain imaging (SFDI), ultrasound, and photoacoustic imaging in preclinical models of 1) peripheral artery disease, 2) traumatic brain injury, and 3) myocardial ischemia to capture imaging biomarkers of vascular and cardiac health in longitudinal studies. We also implement deep learning on preclinical ultrasound and photoacoustic images of the cardiac left ventricle to automatically extract regions of interest to calculate radial strain and oxygen saturation. Eventually findings from this work may help improve clinical cardiovascular disease diagnosis, prognosis, and treatment. Zoom Link: https://purdue-edu.zoom.us/j/95670493593?pwd=cHV1aUJHOTRJSjlvUGx2NUhEZkw4UT… BME PhD Defense Announcement for Anastasiia Vasiukhina (L. Solorio, advisor), Mon., April 3, 10:00 a.m., MJIS 2001 or via Zoom. Title of presentation: Small-scale Technologies for Enhanced Diagnostics and Therapeutics. Committee: Luis Solorio, Chair; Craig J. Goergen; David J. Cappelleri; Yoon Yeo Abstract: Miniaturization of technologies to milli-, micro- and nanoscale offers numerous advantages for diagnostic and therapeutic biomedical applications. In comparison to their macro-scale counterparts, these small-scale systems are more portable, less invasive and less costly. They can facilitate rapid, sensitive and high throughput detection of abnormalities, help track disease progression, reduce sample consumption and improve therapeutic efficacy of drug delivery while decreasing systemic toxicity. Thus, there is clearly a need for creating innovative milli-, micro- and nanoscale tools that can uncover new possibilities in detection and treatment of various types of diseases. The overall objective of this dissertation was to develop novel small-scale technologies that could help enhance diagnostic and/or therapeutic outcomes in patients with cancer, opioid addiction and inflammatory bowel disease. First, we developed an echogenically stable nanodroplet ultrasound contrast agent with potential applications in diagnostic extravascular tumor imaging and targeted cancer therapies. Then, we created a polymer blend microsphere system that could be integrated in prescription opioid tablets to develop an abuse-deterrent formulation against smoking. Finally, we designed a release system for localized delivery of aminosalicylates from magnetically actuated millirobots in the colon to improve therapeutic outcomes in patients suffering from inflammatory bowel disease. Overall, the technologies we developed could serve as a basis for designing diagnostic and therapeutic tools that are superior to currently existing platforms. Zoom Link: https://purdue-edu.zoom.us/j/92472577791?pwd=YUxuSDVPMlV3cHFBY1lYanJPYmFWdz… Meeting ID: 924 7257 7791, Passcode: 473469 BME PhD Defense Announcement for Jonathan Cody (E. Pienaar, advisor), Tues., April 4, 1:30 p.m., DLR 131 and via Zoom. Title of presentation: "Mathematical Modeling of Interluekin-15 Therapy for Human Immunodeficiency Virus." Committee: Elsje Pienaar (Major Professor), Tamara Kinzer-Ursem, Nan Kong, Shelby O'Connor, David Umulis Abstract: Interleukin-15 (IL-15) is a cytokine that promotes maintenance and activation of cytotoxic immune cells. Therapeutic IL-15 stimulates these cells to fight cancer and chronic infections, such as Human Immunodeficiency Virus (HIV). Animal models of HIV have demonstrated that IL-15 agonists can suppress the virus, but this was transient and was not observed in all cohorts. We developed a mechanistic mathematical model of IL-15 therapy of HIV to explain these differences in efficacy and to explore solutions. First, the model was applied to evaluate mitigating factors, including immune regulation, viral escape, and drug tolerance, using Akaike Information Criterion. We found that immune regulatory mechanisms could explain the viral rebound observed with continued IL-15 therapy. Next, the model was expanded to allow it to simultaneously explain both the transient viral suppression noted above and the lack of viral suppression observed in another animal cohort. In this cohort, the model suggested that higher pre-treatment viral load came with higher activation of immune cells and a balancing regulatory inhibition of cytotoxicity. Finally, we conducted stability analysis at a range of IL-15 therapeutic strengths. While there was an ideal IL-15 strength, monotherapy could not maintain viral levels below what would clinically be considered to be safely controlled. Stable viral control in the model required the combination of IL-15 with blockade of key regulatory pathways. Immune therapy of complex diseases will likely require combinations of medicines that boost the immune response at multiple key points. Mathematical models like this can expedite development of these treatments. Place: Hall for Discovery and Learning Research DLR 131 and on Zoom https://purdue-edu.zoom.us/j/94454650628?pwd=ZnFUWkJCSXFtSER4VlVPS2xqeVlJQT… Frontiers in Biophysics Seminar Series, Wed., Apr. 5, 1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present "Mechanical Stability of Microtubules." Microtubules are rigid polymers of tubulin that give structure to cells and serve as tracks for molecular motors. Until recently, the growth and shrinkage of microtubules was thought to be confined to their ends. Over the last few years, however, evidence has emerged that exchange of tubulin in and out of microtubules can take place within the lattice and not just at the ends. I will present our recent work on the microtubule severing protein spastin on microtubule dynamics as well as measurements of the forces necessary to remove tubulin from the lattice. This seminar is sponsored by the Molecular Biophysics Training Program (MBTP), Structural and Computational Biology and Biophysics (SCBB) and the Weldon School of Biomedical Engineering. BME Master's Defense Announcement for Sydney Clark (C. Goergen, advisor), Thurs., Apr. 6, 9:00 a.m., MJIS 2001 or via Zoom. Title: Cardiovascular Applications of Non-Invasive Imaging. Thesis Committee: Craig J. Goergen, Chair; Steven R. Steinhubl; Gregory J. Loomis Abstract: Cardiovascular disease has been the leading cause of death in the United States for over 70 years. To evaluate the extent and progression of cardiovascular disease, non-invasive imaging techniques are frequently used clinically and pre-clinically. Current echocardiographic and cine magnetic resonance approaches rely on measurements that are typically obtained from two-dimensional images, which assumes uniformity of the structure being evaluated. To explore methods to potentially address these shortcomings, our group has developed and validated high frequency four-dimensional ultrasound techniques as well as created a software toolbox that allows for measurement of myocardial kinematics. In this thesis, I assisted in the application of these methods to two murine models of disease states: myocardial infarction and aortic aneurysm. Another study I aided in focused on cardiac magnetic resonance imaging data from patients with Duchenne muscular dystrophy. From our software, we are able to obtain various strain and strain rate estimates that reveal significant functional changes in infarction and Duchenne muscular dystrophy earlier than standard measurement techniques. Furthermore, we are able to identify vascular expansion, transmural thickening, and changes in hemodynamics prior to aneurysm development. Earlier detection and localization allows for more targeted surveillance and interventions, which ultimately may result in improved clinical outcomes. Ideally, these findings can be used to expand the capabilities of cardiac research and the development of clinically applicable imaging techniques and treatments to better address underlying cardiovascular pathophysiology. Zoom link: https://iu.zoom.us/j/89684973230 Participants Needed for Research Study: (Aditya Shanghavi is a graduate student in Biomedical Engineering at Purdue.) I am currently working on a research project under the direction of my advisor, Dr Anne Sereno. We are inviting you to participate in a brief arm movement study. We are specifically looking for participants aged 45-85 with no history of neurological diseases who are fluent in English and have adequate hearing (with or without amplification) to process verbal instruction and adequate vision to see the computer screen. Participants should be able to perform simple upper arm motions without experiencing major pain or discomfort. We will use non-invasive motion sensors on a wristband to collect arm motion signals during normal and simulated abnormal movements (after viewing short videos) as well as an eye tracker to collect eye motion signals during a prosaccade-antisaccade task. This study's goal is to develop algorithms to detect latencies and amplitudes of movements and to quantify the sensitivity, reliability, and accuracy of the sensors and these algorithms to differentiate normal versus simulated abnormal movements. The study should take no more than 60 minutes and it will be conducted in PSYCH 3125. We will highly appreciate you taking time out of your busy schedule and will compensate you $15 for your help in our research study in addition to our heartfelt gratitude. This study is conducted in accordance with IRB # IRB-2022-1299. If you have more questions regarding this study, please contact Aditya Shanghavi at ashangha(a)purdue.edu<mailto:ashangha@purdue.edu>. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Fall 2023, 3.0 credit hours Wednesdays 11:30-2:20 in MJIS 1083 (in person attendance only) Prerequisite: BME Graduate Standing Course Description: The unique medical needs of pediatric patients in the context of current and emerging clinical technologies are presented in this novel course. Anatomical, physiological, and pathophysiological underpinnings of diseases in infants and children are studied. Unique aspects of pediatric device design, regulation, and translation, including clinical studies and ethical considerations, are explored. Numerous clinical sub specialties such as cardiology, surgery, nephrology, pulmonology, and gastroenterology are examined in terms of technology adoption and remaining clinical needs. Future directions in device development and emerging trends in patient care are considered throughout. Weekly Course Topics: August 23 Pediatrics Introduction August 30 Neonatology Introduction September 6 Pediatric Device Design and Development I September 13 Pediatric Device Design and Development II September 20 Pediatric Device Regulation September 27 Pediatric Clinical Studies October 4 Pediatric Cardiology October 18 Pediatric Cardiovascular Surgery October 25 Pediatric Nephrology November 1 Pediatric Pulmonology November 8 Pediatric Wound Healing November 15 Pediatric Gastroenterology November 29 Ethical Considerations in Pediatrics December 6 Future Directions and Trends Primary Instructor: George Wodicka, MJIS 3036, wodicka(a)purdue.edu Numerous experts from the Indiana University School of Medicine Department of Pediatrics, Riley Hospital for Children, and Cook Medical, Inc. will actively participate. Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001) Week Date Speaker Host Week 10 3/22/2023 Dr. Nicole Adams, Clinical Associate Professor and RWJF Nursing and Health Policy Fellow, Purdue University School of Nursing Dr. Young Kim Week 11 3/29/2023 Dr. Nimmi Ramanujam Robert W. Carr Professor of Biomedical Engineering, Department of Pharmacology and Cell Biology, Director of The Center for Global Women's Health Technologies, Duke University Dr. Jackie Linnes Week 12 4/5/2023 Dr. Junhong Chen Crown Family Professor of Molecular Engineering and Lead Water Strategist at Argonne National Laboratory Dr. Chi Hwan Lee Week 13 4/12/2023 Dr. Chien-Chi Lin Thomas J. Linnemeier Guidant Foundation Endowed Chair & Professor of BME at IUPUI Dr. Young Kim Week 14 4/19/2023 Dr. Rachel Surowiec Assistant Professor of BME at IUPUI Dr. Young Kim Week 15 4/26/2023 Dr. James Moon J. G. Searle Professor, Pharmaceutical Sciences Professor, Biomedical Engineering at Michigan Dr. Chi Hwan Lee The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts<http://ogww.mj.am/lnk/AU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90y…> Attachments Peck_flyer Trailblazers-in-Engineering Grad Appreciation Week -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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BME PhD Defense Announcement for Jonathan Cody (E. Pienaar, advisor)
by May, Sandra M 17 Mar '23

17 Mar '23

BME PhD Defense Announcement for Jonathan Cody (E. Pienaar, advisor) Everyone is invited to attend the public presentation beginning at 1:30 PM. Title: “Mathematical Modeling of Interluekin-15 Therapy for Human Immunodeficiency Virus” Time: Tuesday, April 4th from 1:30-3:30 PM Place: Hall for Discovery and Learning Research DLR 131 and on Zoom https://purdue-edu.zoom.us/j/94454650628?pwd=ZnFUWkJCSXFtSER4VlVPS2xqeVlJQT… Committee: Elsje Pienaar (Major Professor), Tamara Kinzer-Ursem, Nan Kong, Shelby O’Connor, David Umulis Abstract: Interleukin-15 (IL-15) is a cytokine that promotes maintenance and activation of cytotoxic immune cells. Therapeutic IL-15 stimulates these cells to fight cancer and chronic infections, such as Human Immunodeficiency Virus (HIV). Animal models of HIV have demonstrated that IL-15 agonists can suppress the virus, but this was transient and was not observed in all cohorts. We developed a mechanistic mathematical model of IL-15 therapy of HIV to explain these differences in efficacy and to explore solutions. First, the model was applied to evaluate mitigating factors, including immune regulation, viral escape, and drug tolerance, using Akaike Information Criterion. We found that immune regulatory mechanisms could explain the viral rebound observed with continued IL-15 therapy. Next, the model was expanded to allow it to simultaneously explain both the transient viral suppression noted above and the lack of viral suppression observed in another animal cohort. In this cohort, the model suggested that higher pre-treatment viral load came with higher activation of immune cells and a balancing regulatory inhibition of cytotoxicity. Finally, we conducted stability analysis at a range of IL-15 therapeutic strengths. While there was an ideal IL-15 strength, monotherapy could not maintain viral levels below what would clinically be considered to be safely controlled. Stable viral control in the model required the combination of IL-15 with blockade of key regulatory pathways. Immune therapy of complex diseases will likely require combinations of medicines that boost the immune response at multiple key points. Mathematical models like this can expedite development of these treatments.

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BME PhD Defense Announcement for Anastasiia Vasiukhina (L. Solorio, advisor)
by May, Sandra M 17 Mar '23

17 Mar '23

BME PhD Defense Announcement for Anastasiia Vasiukhina (L. Solorio, advisor) Everyone is invited to attend the public presentation beginning at 10:00 am. Title: small-scale technologies for enhanced diagnostics and therapeutics Date and time: April 3rd, 2023 at 10:00 am Location: MJIS 2001 or Zoom* Committee: Luis Solorio, Chair; Craig J. Goergen; David J. Cappelleri; Yoon Yeo Abstract: Miniaturization of technologies to milli-, micro- and nanoscale offers numerous advantages for diagnostic and therapeutic biomedical applications. In comparison to their macro-scale counterparts, these small-scale systems are more portable, less invasive and less costly. They can facilitate rapid, sensitive and high throughput detection of abnormalities, help track disease progression, reduce sample consumption and improve therapeutic efficacy of drug delivery while decreasing systemic toxicity. Thus, there is clearly a need for creating innovative milli-, micro- and nanoscale tools that can uncover new possibilities in detection and treatment of various types of diseases. The overall objective of this dissertation was to develop novel small-scale technologies that could help enhance diagnostic and/or therapeutic outcomes in patients with cancer, opioid addiction and inflammatory bowel disease. First, we developed an echogenically stable nanodroplet ultrasound contrast agent with potential applications in diagnostic extravascular tumor imaging and targeted cancer therapies. Then, we created a polymer blend microsphere system that could be integrated in prescription opioid tablets to develop an abuse-deterrent formulation against smoking. Finally, we designed a release system for localized delivery of aminosalicylates from magnetically actuated millirobots in the colon to improve therapeutic outcomes in patients suffering from inflammatory bowel disease. Overall, the technologies we developed could serve as a basis for designing diagnostic and therapeutic tools that are superior to currently existing platforms. *Anastasiia Vasiukhina is inviting you to a scheduled Zoom meeting. Topic: Anastasiia Vasiukhina PhD Defense Time: Apr 3, 2023 10:00 AM America/Indiana/Indianapolis Join Zoom Meeting https://purdue-edu.zoom.us/j/92472577791?pwd=YUxuSDVPMlV3cHFBY1lYanJPYmFWdz… Meeting ID: 924 7257 7791 Passcode: 473469

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BME Master's Defense Announcement for Sydney Clark (C. Goergen, advisor)
by May, Sandra M 16 Mar '23

16 Mar '23

BME Master's Defense Announcement for Sydney Clark (C. Goergen, advisor) Everyone is invited to attend the public presentation beginning at 9 am. Title: Cardiovascular Applications of Non-Invasive Imaging Date & Time: April 6th, 9 am - 11 am Location: MJIS 2001 or zoom: https://iu.zoom.us/j/89684973230 Thesis Committee: Craig J. Goergen, Chair; Steven R. Steinhubl; Gregory J. Loomis Abstract: Cardiovascular disease has been the leading cause of death in the United States for over 70 years. To evaluate the extent and progression of cardiovascular disease, non-invasive imaging techniques are frequently used clinically and pre-clinically. Current echocardiographic and cine magnetic resonance approaches rely on measurements that are typically obtained from two-dimensional images, which assumes uniformity of the structure being evaluated. To explore methods to potentially address these shortcomings, our group has developed and validated high frequency four-dimensional ultrasound techniques as well as created a software toolbox that allows for measurement of myocardial kinematics. In this thesis, I assisted in the application of these methods to two murine models of disease states: myocardial infarction and aortic aneurysm. Another study I aided in focused on cardiac magnetic resonance imaging data from patients with Duchenne muscular dystrophy. From our software, we are able to obtain various strain and strain rate estimates that reveal significant functional changes in infarction and Duchenne muscular dystrophy earlier than standard measurement techniques. Furthermore, we are able to identify vascular expansion, transmural thickening, and changes in hemodynamics prior to aneurysm development. Earlier detection and localization allows for more targeted surveillance and interventions, which ultimately may result in improved clinical outcomes. Ideally, these findings can be used to expand the capabilities of cardiac research and the development of clinically applicable imaging techniques and treatments to better address underlying cardiovascular pathophysiology.

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