[cid:image003.jpg@01D95B11.3D9F9320] BME MONDAY ROUNDTABLE March 20, 2023 DEPUTY HEAD'S NOTE Dear all, Welcome back! I hope you had a wonderful Spring Break wherever you were with family, friends, and colleagues. It was good to take some time off as we all deserved it. I hope you kept warm. We got some white stuff on the ground over the past weekend here in West Lafayette. I had an emotional rollercoaster watching this season of Purdue Men's basketball coming to an end. They won the Big Ten Conference tournament at the beginning of the break and lost to a No. 16-seed on Thursday. I was in town the whole break and was with my students at the Bryant as the loss unfolded. Disbelief was written all over many diner's faces that night at the Bryant. Business as usual. Now we have the second half of the spring semester ahead of us and have another season starting this fall to look forward to. Mike Heinz and Tami Kinzer-Ursem presented a great amount of detail on the newly formatted BME PhD qualifier in the recent BME faculty meeting (3/10). I believe this is a good measure we are taking to better control the quality of our PhD students and give all of us a formal channel to proactively mentor them. We will have some fun in April and May together with our students. As far as the Indianapolis faculty rehoming process goes, we are all set with the two Primary Committee meetings on March 28th and April 4th. We want to have a fair and transparent review process. We want to welcome those who are excellent in their academic careers and who desire to help our school become better with the integration. I know Jo has put the BRAG Session announcement at the top of next block. I still want to use this opportunity to give a shout-out to Kaisa Ejendal, Linlin Li, and Monisha Elumalai, the research scientist organizers. I also want to personally thank Taimoor Qazi and the others who have contributed to BRAG. The following may be an incomplete list * Leo Green: What I wish I knew as a senior postdoc * Deva Chan and Craig Goergen: The needle in the haystack: How to identify, apply for and get the tenure track job of your dreams * Loran Solorio: Breaking into Industry R&D: Tips from a former postdoc * Young Kim: The good, the bad, and the ugly of clinical research as a biomedical engineer * Andrew Brightman: Responsive mentoring for responsible research UPCOMING IMPORTANT DATES Week of March 20 Mon., March 20: BRAG Session (for BME postdocs, visiting scientists and research staff), 11:45 a.m. - 1:00 p.m., MJIS 2001. Meet with one of BME's newest faculty members, Assistant Professor Taimoor Qazi. Taimoor will talk about finding and applying for jobs in academia and what to expect as a new faculty member and title is "Transitioning from a postdoc to a faculty position - what it's like on the other side". Lunch will be provided. Please RSVP via the Microsoft office invitation (sent separately) or directly to kejendal@purdue.edu<mailto:kejendal@purdue.edu> so we can order lunches. Please indicate any dietary restrictions. Mon., March 20: Center for Diabetes and Metabolic Diseases Research Seminar, 12:00 p.m., via Zoom. Renata Pereira Alambert, Assistant Professor of Internal Medicine - Endocrinology and Metabolism, University of Iowa, will present "Novel Players in Brown Adipose Tissue Regulation of Metabolic Health." Zoom link: https://iu.zoom.us/s/87501979533 Tues., March 21: BME PhD Defense Announcement for Rashed Almousa (D. Xie and K. Park, Co-Chairs), 9:00 a.m. via Zoom. Title of presentation: "Surface Modification of PVC/PU for Enhanced Biofouling Resistance." Tues., March 21: Structural Engineering Seminar, 4:30 p.m., HAMP 1144. Professor Ayhan Irfanoglu, Associate Head of Lyles School of Civil Engineering will present a seminar entitled "First Impressions of the February 2023 Earthquake Disaster in Turkey." Abstract: A sequence of earthquakes on 6 February 2023 struck the south-southeastern part of Turkey, bordering Syria. Ground motions recorded near the source fault zone are among the most intense to struck urban built environment. Several cities, large and small, new and historic, were devastated. Just in Turkey, the disaster zone includes over 12 million people in 11 provinces. It is reported that more than fifty thousand lives were lost in Turkey and Syria in collapsed buildings. Observations made during a rapid reconnaissance, February 15-19, supported by the Earthquake Engineering Research Institute will be shared. Reflections will be made on the current practice of earthquake engineering. Wed., March 22: BME Seminar Series, 9:30 a.m., MJIS 1001 and via Zoom. Dr. Nicole Adams, Clinical Associate Professor and RWJF Nursing and Health Policy Fellow, Purdue University School of Nursing. Title of presentation: "The meaningful use of technology in healthcare: Different languages, different goals." Wed., March 22: Seminar for Neurotrauma and Diseases, 4:00 p.m., via Zoom. Brad Duerstock, PhD, Professor of Practice for the Weldon School of Biomedical Engineering at Purdue will present "Detection of autonomic dysreflexia in persons with spinal cord injury using noninvasive sensors." The Seminar for Neurotrauma and Diseases is organized by the Center for Paralysis Research and is sponsored by Plexon, the Purdue Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. Zoom link: https://bit.ly/3HsTf5R Wed., March 23: Seminars in Hearing Research, 10:30 a.m., LYLE 1150 and via Zoom. Leroy Medrano, B.S. COHC, SLHA will present "Cortical measures of cognitive engagement during speech processing." Cochlear Implants (CI) are one of the most successful medical prostheses in the world. Yet, it is still unclear as to why there is substantial variability in speech recognition performance among CI users. Attempts to better understand this enigma have used behavioral tasks to examine cognitive ability in the domain of executive function in adult CI users. Zoom link: https://purdue-edu.zoom.us/j/4326340458 Upcoming important deadlines and info. Mon., March 27: Special BME Seminar, 9:30 a.m., MJIS 2001. Joseph R. Leach, MD, PhD, Assistant Professor in Residence, Department of Radiology and Biomedical Engineering at the University of California, San Francisco, will present "Abdominal Aortic Aneurysm Assessment - Moving Beyond Measurement." Thurs., March 30: BME PhD Defense Announcement for Katherine Leyba (Dr. Craig Goergen, Advisor), 10:00 a.m., MJIS 2001 and via Zoom. Research title: Optical and Acoustic-based Imaging Methods for Quantification of Oxygenation and Strain in Murine Cardiovascular Disease Models. Thurs., March 30-Fri., March 31: 18th Annual Garnet E. Peck Symposium, Purdue Department of Industrial and Physical Pharmacy, Stewart Center and Purdue Memorial Union. 1-1/2 day symposium to showcase advances in pharmaceutical manufacturing, with sessions focusing on biologics and small molecules. Presentations include the latest developments on excipients and continuous manufacturing, novel processing technologies as well as a poster session and 3-minute student thesis competition. Registration is now open: http://www.purdue.edu/conferences/Peck2023 . There is a $15 registration fee. See attached flyer. Mon. Apr. 3 - Fri., Apr. 7: Grad Student Appreciation Week. Our grad students are superheroes! Let us show you how much we appreciate you! Monday - Not all heroes wear capes! Grab a token of appreciation, 3-4:00 p.m.; Tuesday - Get your POW! back with a snack, 10-11:00 a.m.; Wednesday - A SOUP-er Peer Mentoring Lunch, 11am-1pm; Thursday - Super-charge your morning! 9:30-10:30 a.m.; Friday - Grab a "Frozone" Treat! 3-4:00 p.m. See flyer for details. Mon., April 3: BME PhD Defense Announcement for Anastasiia Vasiukhina (L. Solorio, advisor), 10:00 a.m., MJIS 2001 or via Zoom. Title of presentation: Small-scale Technologies for Enhanced Diagnostics and Therapeutics. Tues., April 4: BME PhD Defense Announcement for Jonathan Cody (E. Pienaar, advisor), 1:30 p.m., DLR 131 and via Zoom. Title of presentation: "Mathematical Modeling of Interluekin-15 Therapy for Human Immunodeficiency Virus." Wed., Apr. 5: Frontiers in Biophysics Seminar Series, 1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present "Mechanical Stability of Microtubules." Thurs., Apr. 6: BME Faculty and Staff Town Hall, 1:00-2:00 p.m., MJIS 2001. Arvind Raman, the next dean of Purdue's College of Engineering starting April 1, will begin hosting town halls for Purdue Engineering's academic units and listening sessions for faculty and staff in April and May. The main goal for the town halls is to seek input and advice on the College's priorities for the coming years. Faculty and staff are invited to attend the town hall of their respective academic unit. Registration is not required for the town halls. A zoom link will be provided for each unit's town hall; they will not be recorded. Thurs., Apr. 6: BME Master's Defense Announcement for Sydney Clark (C. Goergen, advisor), 9:00 a.m., MJIS 2001 or via Zoom. Title: Cardiovascular Applications of Non-Invasive Imaging. Fri., May 12-Sat., May 13: Inaugural Krannert Cardiovascular Research Center Biennial, sponsored by the Indiana University School of Medicine at the JW Marriott and Eiteljorg Museum, Indianapolis, IN. Krannert is conducting a nationally recognized CME event May 12-13 (Fri-Sat) on Myocardial Infarction & Reperfusion Injury. We cordially invite you to join us if possible. We have a strong line up of speakers on the topic who are renowned for their decades of contributions to the field. We are hoping for an event that would capture almost 50 years of activity in the field of ischemia/reperfusion and place it in a context to chart the course forward with the goal of improving care for heart attack patients. This is a great opportunity to meet thought leaders, engage in transformative science, and hopefully be part of a journey to advance CV research. For Program Agenda & Registration, please follow the link: https://medicine.iu.edu/institutes/cardiovascular/research/biennial Thurs., May 25: Application Deadline for Trailblazers in Engineering workshop, to be held on the Purdue campus July 25-26. Trailblazers in Engineering (TBE) is a multi-day workshop focused on preparing future outstanding engineering scholars for future engineering faculty careers who are also committed to increase the success of underrepresented communities of engineers. Trailblazers in Engineering Fellows are selected not only for their outstanding scholarly achievements but also for their potential impact in expanding representation and diversity in engineering. See attached flyer for application instructions. Committee Updates Graduate Office Update Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001). Full schedule below. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Details below. BMEGSA General Body Meetings - All BME graduate students are welcome, and encouraged to attend! Upcoming meetings: Friday, March 31st 12:30PM-1:30PM Thursday, April 20th 3:30PM-4:30PM All meetings are held in MJIS 2001 in person only. Graduate Admissions Update Fall 2022 (Fall 2023 Admit Term) BME Graduate Admissions DateDATE Activity Mar 31 Due: All PhD students to be decisioned as either admit, deny or hold April 15 Graduate applicant acceptance deadline Research Update Participants needed for a Motor Function Study, "Development of a Diagnostic System for Assessment of Motor Impairment," IRB# IRB-2022-1299. See below for details. Resources and further information BME PhD Defense Announcement for Rashed Almousa (D. Xie and K. Park, Co-Chairs), Tues., March 21, 9:00 a.m. via Zoom. Title of presentation: "Surface Modification of PVC/PU for Enhanced Biofouling Resistance." Thesis Committee members: Prof. Dong Xie (Co-Chair), Prof. Kinam Park (Co-Chair), Prof. Jiliang Li, Prof. Sungsoo Na Abstract: Medical devices are at risk of biofouling within seconds after implantation, which can lead to thrombus formation and bacterial contamination. These issues can negatively impact the performance and reliability of the device. Poly(vinyl chloride) (PVC) and polyurethane (PU) are popular synthetic polymers used in biomedical applications, but their hydrophobic nature makes them susceptible to biofouling. To improve their biocompatibility, their surfaces must be modified to be antifouling. However, achieving a thoroughly coated surface through homogeneous activation and effective modification with antifouling polymers remains a challenge, despite recent advancements in polymer surface modification. In this dissertation, we modified the surfaces of medical-grade PVC and PU using hydrophilic and biocompatible polymer brushes via wet chemistry approaches in an aqueous medium. Specifically, we activated the PVC surface with amino groups and then modified it with either modified or synthesized hydrophilic polymers end-capped with reactive groups. Additionally, we coupled a functionalized surface initiator to the activated PVC surface to allow the grafting of different hydrophilic polymers via conventional in situ free-radical polymerization. We followed a similar process to activate the PU surface with amino groups and then coupled a co-initiator derivative to allow the grafting of different hydrophilic polymers via conventional in situ free radical polymerization as a redox initiation system. All the modified surfaces of PVC and PU have exhibited a significant increase in wettability, as well as extremely effective antifouling effects against cell and bacterial adhesion. Overall, the findings of this work demonstrate the applicability of wet chemistry surface modification for PVC- or PU-based medical devices and supplies in biofouling-resistant applications. Zoom Link: https://purdue-edu.zoom.us/j/99594936275 BME Seminar Series, Wed., March 22, 9:30 a.m., MJIS 1001 and via Zoom. Dr. Nicole Adams, Clinical Associate Professor and RWJF Nursing and Health Policy Fellow, Purdue University School of Nursing. Title of presentation: "The meaningful use of technology in healthcare: Different languages, different goals." Abstract: Healthcare is a huge sector of our economy and touches all of our lives. It is also a place where efficiency, process improvement, and advanced technology can improve outcomes, both health and financial. However, providing care to a patient and advancing new technologies do not always align. This can be due to a misalignment of the language of medicine and the language of engineering, or a misalignment of the goals of medicine and the goals of engineering. In this seminar, Dr. Adams will talk about some of her active and developing projects which incorporate new technology in healthcare applications. She will focus on the alignment of clinical goals with technological advances and a mutually beneficial relationship between nursing and engineering on a project. Biography: Dr. Adams conducts research focused on community responses and collaborations addressing the opioid crisis, substance use, and mental health. As an associate member of the Regenstrief Center for Healthcare Engineering (RCHE), she works closely with engineers to develop innovative tools for use by communities and organizations. Dr. Adams applies concepts from Systems Thinking and Complex Adaptive Models to evaluate community resources and build collaboration between entities. She also focuses on including human factors and end-user perspectives into new technologies to improve healthcare delivery and organizational efficiency. Dr. Adams has created educational videos, presentations, and modules about substance use and recovery that are approachable to those in academia as well as the general public. Her previous research has included topics related to health economics, hospital payment systems, and value-based purchasing. ~ BME Host: Young Kim ~ Zoom link: https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09 NOTE: Students registered for the seminar are expected to attend in-person. Special BME Seminar, Mon., March 27, 9:30 a.m., MJIS 2001. Joseph R. Leach, MD, PhD, Assistant Professor in Residence, Department of Radiology and Biomedical Engineering at the University of California, San Francisco, will present "Abdominal Aortic Aneurysm Assessment - Moving Beyond Measurement." Abstract: Abdominal aortic aneurysms (AAA) have a pooled global prevalence of 4.8% and are most common in men 65 years or older. Small AAAs (<4 cm) are commonly asymptomatic and pose little danger, while larger AAAs have a significant risk of fatal rupture that increases with increasing aneurysm diameter. Despite decades of research elucidating the histologic and biochemical features of AAA evolution, clinicians have relatively little capacity to predict or modify AAA progression in practice - we are lacking an understanding of AAA progression on a patient-specific basis, informed by factors readily assessed during periodic imaging-based surveillance. In his talk, Dr Leach will review the current state-of-the-art in clinical AAA evaluation, and present ongoing research on a comprehensive AAA assessment in which aneurysm measurement is augmented by advanced imaging-based measures of aneurysm inflammation, biomechanics, and higher-order morphologic features. Bio: Joseph R Leach, MD PhD is an Assistant Professor in Residence in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Leach obtained his PhD in Bioengineering in 2009 from University of California -Berkeley, and completed medical school, residency, and a fellowship in abdominal imaging at UCSF prior to joining the faculty in 2018. Dr. Leach has broad clinical and research interests in vascular disease and applies advanced imaging techniques and imaging-based biomechanical modeling to better understand factors influencing disease initiation, progression, and patient outcomes. Outside of the hospital, Dr. Leach enjoys cooking for his wife, Joyce and their cats Jacks and Nigel, and is a lifelong musician and terrible dancer. ~BME Host: Vitaliy Rayz~ BME PhD Defense Announcement for Katherine Leyba, Thurs., March 30, 10:00 a.m., MJIS 2001 and via Zoom. Research title: Optical and Acoustic-based Imaging Methods for Quantification of Oxygenation and Strain in Murine Cardiovascular Disease Models. Thesis Committee members: Dr. Craig Goergen (Chair), Dr. Fang Huang, Dr. Charles Bouman, Dr. Pierre Sicard Abstract: Cardiovascular disease (CVD) is the leading cause of death worldwide and is expected to increase direct medical costs in the U.S. to $749 billion by the year 2035. Diagnosis of CVD through imaging techniques can improve our understanding of CVD progression and its associated risks through visualization of anatomical features and biological constituents. Non-invasive imaging relies on optimal image quality for visualization of such tissue structures that can be difficult to identify and segment. While various imaging modalities are used to determine tissue characteristics, many lack the spatial resolution that optics-based imaging can provide, which can assess hemodynamic parameters in preclinical models of ischemic disease. Acoustic-based imaging can complement optics-based imaging by providing anatomical and location-specific information of tissues with greater penetration depth. Even with all the advancements in imaging technology, however, limitations still exist in non-invasively, efficiently, and accurately capturing biologically relevant information with adequate spatial and temporal resolution. Furthermore, reproducible feature extraction is difficult due to a lack of standardization in the field, making it difficult to implement when image quality varies. In this work, we implement spatial frequency domain imaging (SFDI), ultrasound, and photoacoustic imaging in preclinical models of 1) peripheral artery disease, 2) traumatic brain injury, and 3) myocardial ischemia to capture imaging biomarkers of vascular and cardiac health in longitudinal studies. We also implement deep learning on preclinical ultrasound and photoacoustic images of the cardiac left ventricle to automatically extract regions of interest to calculate radial strain and oxygen saturation. Eventually findings from this work may help improve clinical cardiovascular disease diagnosis, prognosis, and treatment. Zoom Link: https://purdue-edu.zoom.us/j/95670493593?pwd=cHV1aUJHOTRJSjlvUGx2NUhEZkw4UT0... BME PhD Defense Announcement for Anastasiia Vasiukhina (L. Solorio, advisor), Mon., April 3, 10:00 a.m., MJIS 2001 or via Zoom. Title of presentation: Small-scale Technologies for Enhanced Diagnostics and Therapeutics. Committee: Luis Solorio, Chair; Craig J. Goergen; David J. Cappelleri; Yoon Yeo Abstract: Miniaturization of technologies to milli-, micro- and nanoscale offers numerous advantages for diagnostic and therapeutic biomedical applications. In comparison to their macro-scale counterparts, these small-scale systems are more portable, less invasive and less costly. They can facilitate rapid, sensitive and high throughput detection of abnormalities, help track disease progression, reduce sample consumption and improve therapeutic efficacy of drug delivery while decreasing systemic toxicity. Thus, there is clearly a need for creating innovative milli-, micro- and nanoscale tools that can uncover new possibilities in detection and treatment of various types of diseases. The overall objective of this dissertation was to develop novel small-scale technologies that could help enhance diagnostic and/or therapeutic outcomes in patients with cancer, opioid addiction and inflammatory bowel disease. First, we developed an echogenically stable nanodroplet ultrasound contrast agent with potential applications in diagnostic extravascular tumor imaging and targeted cancer therapies. Then, we created a polymer blend microsphere system that could be integrated in prescription opioid tablets to develop an abuse-deterrent formulation against smoking. Finally, we designed a release system for localized delivery of aminosalicylates from magnetically actuated millirobots in the colon to improve therapeutic outcomes in patients suffering from inflammatory bowel disease. Overall, the technologies we developed could serve as a basis for designing diagnostic and therapeutic tools that are superior to currently existing platforms. Zoom Link: https://purdue-edu.zoom.us/j/92472577791?pwd=YUxuSDVPMlV3cHFBY1lYanJPYmFWdz0... Meeting ID: 924 7257 7791, Passcode: 473469 BME PhD Defense Announcement for Jonathan Cody (E. Pienaar, advisor), Tues., April 4, 1:30 p.m., DLR 131 and via Zoom. Title of presentation: "Mathematical Modeling of Interluekin-15 Therapy for Human Immunodeficiency Virus." Committee: Elsje Pienaar (Major Professor), Tamara Kinzer-Ursem, Nan Kong, Shelby O'Connor, David Umulis Abstract: Interleukin-15 (IL-15) is a cytokine that promotes maintenance and activation of cytotoxic immune cells. Therapeutic IL-15 stimulates these cells to fight cancer and chronic infections, such as Human Immunodeficiency Virus (HIV). Animal models of HIV have demonstrated that IL-15 agonists can suppress the virus, but this was transient and was not observed in all cohorts. We developed a mechanistic mathematical model of IL-15 therapy of HIV to explain these differences in efficacy and to explore solutions. First, the model was applied to evaluate mitigating factors, including immune regulation, viral escape, and drug tolerance, using Akaike Information Criterion. We found that immune regulatory mechanisms could explain the viral rebound observed with continued IL-15 therapy. Next, the model was expanded to allow it to simultaneously explain both the transient viral suppression noted above and the lack of viral suppression observed in another animal cohort. In this cohort, the model suggested that higher pre-treatment viral load came with higher activation of immune cells and a balancing regulatory inhibition of cytotoxicity. Finally, we conducted stability analysis at a range of IL-15 therapeutic strengths. While there was an ideal IL-15 strength, monotherapy could not maintain viral levels below what would clinically be considered to be safely controlled. Stable viral control in the model required the combination of IL-15 with blockade of key regulatory pathways. Immune therapy of complex diseases will likely require combinations of medicines that boost the immune response at multiple key points. Mathematical models like this can expedite development of these treatments. Place: Hall for Discovery and Learning Research DLR 131 and on Zoom https://purdue-edu.zoom.us/j/94454650628?pwd=ZnFUWkJCSXFtSER4VlVPS2xqeVlJQT0... Frontiers in Biophysics Seminar Series, Wed., Apr. 5, 1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present "Mechanical Stability of Microtubules." Microtubules are rigid polymers of tubulin that give structure to cells and serve as tracks for molecular motors. Until recently, the growth and shrinkage of microtubules was thought to be confined to their ends. Over the last few years, however, evidence has emerged that exchange of tubulin in and out of microtubules can take place within the lattice and not just at the ends. I will present our recent work on the microtubule severing protein spastin on microtubule dynamics as well as measurements of the forces necessary to remove tubulin from the lattice. This seminar is sponsored by the Molecular Biophysics Training Program (MBTP), Structural and Computational Biology and Biophysics (SCBB) and the Weldon School of Biomedical Engineering. BME Master's Defense Announcement for Sydney Clark (C. Goergen, advisor), Thurs., Apr. 6, 9:00 a.m., MJIS 2001 or via Zoom. Title: Cardiovascular Applications of Non-Invasive Imaging. Thesis Committee: Craig J. Goergen, Chair; Steven R. Steinhubl; Gregory J. Loomis Abstract: Cardiovascular disease has been the leading cause of death in the United States for over 70 years. To evaluate the extent and progression of cardiovascular disease, non-invasive imaging techniques are frequently used clinically and pre-clinically. Current echocardiographic and cine magnetic resonance approaches rely on measurements that are typically obtained from two-dimensional images, which assumes uniformity of the structure being evaluated. To explore methods to potentially address these shortcomings, our group has developed and validated high frequency four-dimensional ultrasound techniques as well as created a software toolbox that allows for measurement of myocardial kinematics. In this thesis, I assisted in the application of these methods to two murine models of disease states: myocardial infarction and aortic aneurysm. Another study I aided in focused on cardiac magnetic resonance imaging data from patients with Duchenne muscular dystrophy. From our software, we are able to obtain various strain and strain rate estimates that reveal significant functional changes in infarction and Duchenne muscular dystrophy earlier than standard measurement techniques. Furthermore, we are able to identify vascular expansion, transmural thickening, and changes in hemodynamics prior to aneurysm development. Earlier detection and localization allows for more targeted surveillance and interventions, which ultimately may result in improved clinical outcomes. Ideally, these findings can be used to expand the capabilities of cardiac research and the development of clinically applicable imaging techniques and treatments to better address underlying cardiovascular pathophysiology. Zoom link: https://iu.zoom.us/j/89684973230 Participants Needed for Research Study: (Aditya Shanghavi is a graduate student in Biomedical Engineering at Purdue.) I am currently working on a research project under the direction of my advisor, Dr Anne Sereno. We are inviting you to participate in a brief arm movement study. We are specifically looking for participants aged 45-85 with no history of neurological diseases who are fluent in English and have adequate hearing (with or without amplification) to process verbal instruction and adequate vision to see the computer screen. Participants should be able to perform simple upper arm motions without experiencing major pain or discomfort. We will use non-invasive motion sensors on a wristband to collect arm motion signals during normal and simulated abnormal movements (after viewing short videos) as well as an eye tracker to collect eye motion signals during a prosaccade-antisaccade task. This study's goal is to develop algorithms to detect latencies and amplitudes of movements and to quantify the sensitivity, reliability, and accuracy of the sensors and these algorithms to differentiate normal versus simulated abnormal movements. The study should take no more than 60 minutes and it will be conducted in PSYCH 3125. We will highly appreciate you taking time out of your busy schedule and will compensate you $15 for your help in our research study in addition to our heartfelt gratitude. This study is conducted in accordance with IRB # IRB-2022-1299. If you have more questions regarding this study, please contact Aditya Shanghavi at ashangha@purdue.edu<mailto:ashangha@purdue.edu>. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Fall 2023, 3.0 credit hours Wednesdays 11:30-2:20 in MJIS 1083 (in person attendance only) Prerequisite: BME Graduate Standing Course Description: The unique medical needs of pediatric patients in the context of current and emerging clinical technologies are presented in this novel course. Anatomical, physiological, and pathophysiological underpinnings of diseases in infants and children are studied. Unique aspects of pediatric device design, regulation, and translation, including clinical studies and ethical considerations, are explored. Numerous clinical sub specialties such as cardiology, surgery, nephrology, pulmonology, and gastroenterology are examined in terms of technology adoption and remaining clinical needs. Future directions in device development and emerging trends in patient care are considered throughout. Weekly Course Topics: August 23 Pediatrics Introduction August 30 Neonatology Introduction September 6 Pediatric Device Design and Development I September 13 Pediatric Device Design and Development II September 20 Pediatric Device Regulation September 27 Pediatric Clinical Studies October 4 Pediatric Cardiology October 18 Pediatric Cardiovascular Surgery October 25 Pediatric Nephrology November 1 Pediatric Pulmonology November 8 Pediatric Wound Healing November 15 Pediatric Gastroenterology November 29 Ethical Considerations in Pediatrics December 6 Future Directions and Trends Primary Instructor: George Wodicka, MJIS 3036, wodicka@purdue.edu Numerous experts from the Indiana University School of Medicine Department of Pediatrics, Riley Hospital for Children, and Cook Medical, Inc. will actively participate. Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001) Week Date Speaker Host Week 10 3/22/2023 Dr. Nicole Adams, Clinical Associate Professor and RWJF Nursing and Health Policy Fellow, Purdue University School of Nursing Dr. Young Kim Week 11 3/29/2023 Dr. Nimmi Ramanujam Robert W. Carr Professor of Biomedical Engineering, Department of Pharmacology and Cell Biology, Director of The Center for Global Women's Health Technologies, Duke University Dr. Jackie Linnes Week 12 4/5/2023 Dr. Junhong Chen Crown Family Professor of Molecular Engineering and Lead Water Strategist at Argonne National Laboratory Dr. Chi Hwan Lee Week 13 4/12/2023 Dr. Chien-Chi Lin Thomas J. Linnemeier Guidant Foundation Endowed Chair & Professor of BME at IUPUI Dr. Young Kim Week 14 4/19/2023 Dr. Rachel Surowiec Assistant Professor of BME at IUPUI Dr. Young Kim Week 15 4/26/2023 Dr. James Moon J. G. Searle Professor, Pharmaceutical Sciences Professor, Biomedical Engineering at Michigan Dr. Chi Hwan Lee The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts<http://ogww.mj.am/lnk/AU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo/6/a2vUEcd_J6SQbZdR8Ley5Q/aHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX2Fic3RyYWN0cw> Attachments Peck_flyer Trailblazers-in-Engineering Grad Appreciation Week -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list