BME PhD Preliminary Exam Announcement for Aditya Shanghavi (A. Sereno and B. Duerstock, co-advisors) Everyone is invited to attend the public presentation beginning at 1:30 pm. Title: A Study of Tremor in Parkinson's Disease Using Signals From Wrist-Worn IMU Sensors Date: 12/06/2022 Time: 1:30 pm Location: MJIS 2001 Virtual Link: https://purdue-edu.zoom.us/j/4520252995 Advisory Committee: Anne B. Sereno, Co-Chair Bradley S. Duerstock, Co-Chair Craig J. Goergen Satyajit S. Ambike Abstract: Parkinson's Disease (PD) is the second most common neurodegenerative disorder with resting tremor (RT) being its most common motor symptom. The literature has revealed that the need for lengthy, clinic-based subjective evaluation by trained neurologists of treatment effects in PD creates challenges for monitoring the progression of the disease and titrating optimal therapeutic therapies. Preliminary studies have shown that features of a power spectral density (PSD) analysis of wrist velocity and acceleration can be used as objective, reliable, and sensitive detectors of RT. Replacing the neurologist's judgement on the progression of the disease is not feasible, yet some aspects of tracking the disorder and treatment may profit from more frequent remote sensor measurements. There is an opportunity to improve patient-care by introducing non-invasive, sensor-based objective measurements of RT using wrist movements that can aid the neurologist with the MS- UPDRS evaluation in the diagnostic process. Success in objectively quantifying RT with such a method would allow physicians to more frequently and remotely monitor patients to change the treatment plan as needed to reduce the severity of harmful side effects of PD medication.