September 2022 - Bmegradstudents-list

BME PhD Defense Announcement for Catherine Weathered (E. Pienaar, advisor)
by May, Sandra M 20 Sep '22

20 Sep '22

BME PhD Defense Announcement for Catherine Weathered (E. Pienaar, advisor) Everyone is invited to attend the public presentation beginning at 11:00am. Title: Multiscale Spatiotemporal Modeling for Human Disease: Agent Based Models for Nontuberculous Mycobacterium Infections and Alzheimer’s Disease Date: September 30, 2022 Time: 11:00am Location: MJIS 2001 and Zoom https://purdue-edu.zoom.us/j/92267006282?pwd=RVo1Nm82R29OUGovNnlJdVVadkR2Zz… Advisory Committee: Elsje Pienaar, PhD, Chair Tamara Kinzer-Ursem, PhD Gregory Knipp, PhD Patricio Escalante, MD Abstract: Human disease and the corresponding immune response occur in three-dimensional space and time. Many diseases are difficult to study experimentally, either in vivo or in vitro, due to the complexity of the system. Despite computational models that can address complexity, many do not capture the spatial aspects of disease. Agent-based models are mechanistic, spatiotemporal computational models that can be integrated with other mathematical models to create multiscale models. Here I describe two agent-based models used to examine spatiotemporal progression and possible treatment strategies for two diseases with low treatment success: Mycobacterium avium complex (MAC) infection and Alzheimer’s Disease. MAC are biofilm-forming environmental microbes capable of residing in human lung nodules, causing MAC pulmonary disease (MAC-PD). Clinical drug susceptibility tests and treatment outcomes are poorly correlated, and nodules are complex and difficult to monitor, leading to low MAC cure rates (45-65%). I have developed an informative model of the initial bacterial deposition in the lung airway and the resulting host innate immune response in MAC-PD. After characterizing this model, I use it to probe the effects of biofilms and resulting macrophage signaling or changes in the immune system, such as those during menopause. By building a better understanding of these system dynamics on the progression of infection, I can quantify the impacts of immunological or environmental interventions such as upregulating macrophage killing, reducing cytokines, or reducing frequency of bacterial exposure. Alzheimer’s Disease (AD) is the leading cause of dementia, with no disease-altering pharmacological intervention. Microglia are phagocytotic neuroimmune cells, known to form barriers around plaques. There has been increased interest in leveraging microglia to slow the progression of neurodegeneration by manipulating these barriers. I developed an agent-based model of microglia barriers at the single plaque level and use knock-out experiments to probe the role of microglial mechanisms and quantify their effects on plaque progression. This increased understanding can be used for immunotherapy interventions to slow or prevent the progression of AD.

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[Bmeroundtable-list] Disaster relief - Puerto Rico hurricane
by Gelfand, Johanna K 19 Sep '22

19 Sep '22

This weekend Puerto Rico was hit by a hurricane, causing many disasters across the island. The Puerto Rican Student Association is collecting items of need or monetary donations to help those affected by this disaster. BME will be placing a box outside MJIS 1051 for this week if anyone wants to contribute any of the listed items. Items of greatest need include: water filters, first-aid kits, non-perishable food, gallons of water, toiletries, solar lanterns, canned and packaged food (rice, oil, pasta, pasta sauce, corned beef, etc.), OTC medications, adult and baby diapers, feminine products, disposable containers and cutlery. If you prefer to give a monetary donation, please contact Angel Enriquez at aenrique(a)purdue.edu<mailto:aenrique@purdue.edu> Our hearts go out to our friends in Puerto Rico, especially our collaborators at the University of Puerto Rico Mayaguez. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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FW: Uncaught bounce notification
by Siemers, Tammy R 19 Sep '22

19 Sep '22

Hi Anna, It looks like we got a bounce from your message that you tried to send out. I just copied and pasted your message and sent it out. I believe you might have used the wrong email address....for future reference, here is the correct email address: bmegradstudents-list(a)ecn.purdue.edu. If that is the one you used, I have no idea what the issue is and may need to send things out for you if they don't go. Tammy -----Original Message----- From: Bmegradstudents-list <mailman-bounces(a)ecn.purdue.edu> Sent: Monday, September 19, 2022 2:05 PM To: bmegradstudents-list-owner(a)ecn.purdue.edu Subject: Uncaught bounce notification The attached message was received as a bounce, but either the bounce format was not recognized, or no member addresses could be extracted from it. This mailing list has been configured to send all unrecognized bounce messages to the list administrator(s). For more information see: https://engineering.purdue.edu/ECN/mailman/admin/bmegradstudents-list/bounce

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BMEGSA QLA Q&A Panel Event!
by Siemers, Tammy R 19 Sep '22

19 Sep '22

Good afternoon BME students! BMEGSA would like to invite 2nd-year BME students in the midst of their QLA Revisions to attend a QLA Q&A Panel Event this Wednesday @ 11:00-11:30am in MJIS 2001! This is your chance to ask questions of students who have already gone through the review process or passed their QLAs to get feedback on how to successfully complete your revisions. We hope this event will be beneficial to aid students in learning how to appropriately respond to reviewer comments for scientific papers even beyond your QLAs, and to get advice on how to write a comprehensive scientific argument. The event will be very casual, so feel free to drop by at any point during the event window for a chance to have your questions answered! Thank you and we look forward to seeing you there! Best, Anna Alford BMEGSA Co-Chair of Professional Development Tammy Siemers She/Her Associate Director, Graduate Education Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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[Bmeroundtable-list] BME Monday Roundtable - September 19, 2022
by Gelfand, Johanna K 19 Sep '22

19 Sep '22

[cid:image005.jpg@01D8CC1C.3544EDD0] BME MONDAY ROUNDTABLE SEPTEMBER 19, 2022 HEADS NOTE Dear Weldon School of Biomedical Engineering, We are in full swing of the Semester an after an eventful past couple of weeks with the Industrial Roundtable, Advisory Board meeting, Art in Research Exhibition, and the George Wodicka Atrium dedication to name a few of our activities, I want to bring your attention back to us- the students, faculty, and staff of our school. First, we would like to remind everybody that mutual respect and inclusion are pillars of our community. Please remember to show everyone mutual respect and know that the we are stronger because of the diverse population and viewpoints that make up the Weldon School. We would also like to remind everyone of the University vacation policy. All graduate students, TAs, RAs, and graduate students on fellowships have vacation time which they are entitled to use. See the following link for more information: https://www.purdue.edu/policies/human-resources/s3.html#:~:text=Fiscal%2Dye…'s%20normal%20rate%20of%20pay As we continue to grow in many ways- with our largest incoming Graduate student class, our largest incoming class of undergraduate students, and more changes ahead- staying true to what it means to be a member of the Weldon School of Biomedical Engineering is critically important. This past spring, the faculty and staff of the school worked hard on establishing our school Core values- for what we expect now and how we plan to grow together. This is even more important now as we are developing new partnerships with the IU School of Medicine and we are starting the process to integrate the IUPUI BME program. Please find the core-values attached to this roundtable email. We will have continual follow up as these are communicated across the school in the following months. Overall, I think our values in Community, Mentorship, Research, and Partnerships provide a strong base upon which to move forward together as a school. Boiler up! QUICK LINKS * Flu shots UPCOMING IMPORTANT DATES Week of September 19 Now – Wed., Oct. 26: Flu shots available to faculty and staff. All benefits-eligible employees and dependents covered on a Purdue health plan are eligible to receive the free flu vaccine. Regardless of location, individuals coming for a flu shot should bring their Purdue University ID (PUID) card or their Anthem medical plan ID card. Full schedule here: https://www.purdue.edu/hr/CHL/Services/FluShots/Faculty-staff-flushots.php Mon., Sept. 19: BME PhD Preliminary Exam Announcement for Conner C. Earl (C. Goergen, advisor), 3:00 p.m., MJIS 2001 and via Zoom. Tues., Sept. 20: Auditory Neuroscience at Purdue Talk, 4:30-5:30 p.m., LYLE 1017. Sarthak Mangla will speak on “Individualized Hearing Aids.” Wed., Sept. 21: Postdoctoral Fellow and Visiting Scholar Breakfast with the Head, 9:00 a.m., MJIS 2001. Details: Breakfast meeting with the Weldon School head, Dr. David Umulis, to celebrate the National Postdoc Appreciation Week. Please come to join a simple breakfast meeting and talk to each other maybe about how your research work is going. We will have bagels, snacks, and coffee! All postdoctoral fellows and visiting scholars are welcome. Wed., Sept. 21: Weldon School of Biomedical Engineering Distinguished Seminar Series, 9:30 a.m. in MJIS 1001 or via Zoom. Peter Caravan, PhD, Professor of Radiology at Harvard Medical School will present “Molecular MR and PET imaging in fibroproliferative diseases.” Wed., Sept. 21: Graduate Mentorship Fellows Seminar: Creating an Individual Development Plan, 4:30 p.m., WALC 2051. Learn more about what an IDP is and how to develop one to discuss with your faculty advisor. Open to all graduate students. Refreshments will be provided. Wed., Sept. 21: The Purdue Chapter of Alpha Eta Mu Beta is proud to present the 2022 Undergraduate BME Student Showcase. Graduate students, faculty, and staff, come learn about the experiences and accomplishments of these great undergraduate students! When 5:30-6:30pm Where: MJIS 1097 Learn more here: https://aembpurdue.wixsite.com/aemb-purdue/team-4 Wed., Sept. 21: The Aerospace Corporation is visiting campus and is interested in meeting with (and hiring!) students from all engineering disciplines. They will have a table set up in the ARMS Atrium on Wednesday 9/21 and then are hosting a tech talk that evening in ARMS. Students registering for the meet & greet can upload resumes for review when they meet with the reps. That’ll basically be a screening for job interviews they’ll be doing the following day (9/22). See attached flyers for details. Thurs., Sept. 22: Purdue Student Soybean Innovation Competition Call-Out, 5:30 p.m., ABE B073. The competition is open to all Purdue students. Registration is OPEN. Team Registration: https://engineering.purdue.edu/ABE/academics/competitions/team_registration Individual Registration: https://engineering.purdue.edu/ABE/academics/competitions/individual_regist… Fri., Sept. 23: IBSC - BME PhD Preliminary Exam Announcement for Navaporn Sritong (J. Linnes, advisor), 2:00 p.m., MRGN 121 and via Zoom. Title: Point-of-care viral molecular detection on paper-based platforms Upcoming important deadlines and info. Mon., Sept. 26: Grant Review Sounding Board Meeting, 1:00-3:00 p.m., MJIS 3041. RSVP to youngkim(a)purdue.edu Mon. Sept. 26: Advance registration deadline for BMES National Conference, to be held October 12-15, San Antonio, TX. Register here: https://www.bmes.org/registration Wed., Sept. 28: BME PhD Preliminary Exam Announcement for Emilee Madsen (J. Linnes, advisor), 11:00 a.m., MJIS 2001. This prelim presentation is open only to those who have signed the Lilly NDA. Title: Hydrogel Microneedle Platform for Electrochemical Sensing of Analytes from Interstitial Fluid Fri., Sept. 30: BME PhD Defense Announcement for Catherine Weathered (E. Pienaar, advisor), 11:00 a.m., MJIS 2001 and via Zoom. Title: Multiscale Spatiotemporal Modeling for Human Disease: Agent Based Models for Nontuberculous Mycobacterium Infections and Alzheimer’s Disease Fri., Sept. 30: 7th Annual Purdue Institute for Drug Discovery Symposium, 9:00-4:30 p.m., Stewart Center Room 218A-D. Mon., Oct. 3: Biomedical Research Associates Group (BRAG) session, 10:00-11:00 a.m., MJIS 2001. Dr. Amruta Inamdar, Senior Career Services Consultant at the Purdue Center for Career Opportunities will hold a session titled: "Resume Development for Advanced Degree Candidates.” All BME postdocs and visiting scientists are welcome to attend. Mon., Oct. 3: BME Faculty Coffee Chats for Grad Students, 9:30-10:30 a.m., MJIS 2041. Faculty host: Eugenio Culurciello. Potential discussion topics: startups commercialization, digital health, health equity Tues., Oct. 4: Graduate Mentorship Seminar Series: Navigating Toxic Environments. 4:30 p.m., online. Learn how to better identify attributes that can lead to poor mentorship relationships or environments and mitigating tips. Guest Speaker: Dr. Vanessa Gonzales-Perez. Mon.-Tues., Oct. 10-11: Purdue Octoberbreak. No classes, but offices and buildings open normal hours. Tues., Oct. 11: MJIS Air Handling Shutdown beginning at 7:30 AM and lasting until approx. 3:00 PM for preventative maintenance of the building’s air systems. This includes air ventilation supplies to all public, classroom and research areas, including chemical fume hoods. There should be NO chemicals used anywhere! All chemical fume hood activity should terminate by 5 PM Monday October 10th. You must make sure all chemical containers are sealed at that time. Chemical fume hoods will have notices posted - do not resume activity until BME staff have verified that work is complete, and have removed postings. Wed., Oct. 19: Special BME Seminar, 9:30 a.m. in MJIS 1001 and via Zoom. Megan Yi-Ping Ho, PhD, Associate Professor of Biomedical Engineering at The Chinese University of Hong Kong will present “Microfluidics for Single Cell Applications.” Wed., Oct. 26: Graduate Mentorship Seminar Series: Building Healthy Mentorship Relationships. 4:30 p.m., WALC 2051. Hear from various COE faculty members and students in a panel-led discussion on how to develop good faculty mentor-student advising relationships. Faculty members welcome! Tues., Nov. 1: Proposals due for WL-Indy Collaborative Seed Grant. (From Jay Akridge): “We are happy to announce a collaborative seed grant competition, which is focused on establishing new research collaborations between faculty located at our two campuses. Please review the attached guidelines and reach out to colleagues to start building new research collaborations. Proposals are due November 1, 2022. See attached RFP. Wed., Nov. 9: Graduate Mentorship Seminar Series: Diversity and Inclusion in Mentorship Relationships, 4:30 p.m., WALC 2051. Learn about how identity and culture are crucial components to recognize in faculty mentor-student advising relationships. Faculty members welcome! Wed., Nov. 9 – Sat., Nov. 12: The Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS) is a go-to conference for underrepresented groups in STEM fields. Scientific or professional development session submissions due July 29. Thurs., Nov. 10: BME Faculty Coffee Chats for Grad Students, 9:30-10:30 a.m., MJIS 3041. Faculty hosts: Hugh Lee, Taimoor Qazi, Steve Steinhubl. Potential discussion topics: ask me anything/ healthcare, academic jobs/academia, visas/international students Thurs., Dec. 8: BME Faculty Coffee Chats for Grad Students, 2:00-3:00 p.m., MJIS 2041. Faculty host: Deva Chan. Potential discussion topics: AMA work-life, teaching & diversity statements, time management PROTECT PURDUE * Fall 2022 update: Protect Purdue Fall expectations https://protect.purdue.edu/updates/fall-2022-what-you-need-to-know/ Committee Updates Graduate Office Update We are once again hosting are faculty coffee chats for grad students. Remember, we need attendance for this event to be successful so get these on your calendars today😊. These coffee chats will attempt to accomplish some priorities that have been shared with us by you: 1. First year students—what a great opportunity to find out more about other labs and find potential mentors for your qual committee. 2. Grad student professional development—to learn/ask/chat about topics of interest to the student either about research or other topics. 3. Increase faculty involvement with graduate students outside of their own lab. 4. Help build community between grad students. Here are the dates and faculty for fall: October Date: October 3rd Time: 9:30-10:30 am Location: MJIS 2041 Faculty host: Eugenio Culurciello Potential discussion topics: startups commercialization, digital health, health equity November Date: November 10th Time: 9:30 am-10:30 am Location: MJIS 3041 Faculty hosts: Hugh Lee, Taimoor Qazi, Steve Steinhubl Potential discussion topics: ask me anything/healthcare, academic jobs/academia, visas/international students December: Date: December 8th Time: 2:00 pm-3:00 pm Location: MJIS 2041 Faculty host: Deva Chan Potential discussion topics: AMA work-life, teaching & diversity statements, time management Please plan to participate in as many as your schedule will allow. There will be free snacks and drinks included. Graduate Admissions Update 1. Purdue Engineering Virtual Graduate Showcase <https://engineering.purdue.edu/Engr/Academics/Graduate/graduate-showcase> - September 25 - 26, 2022. 2. Graduate Diversity Visitation Program (GDVP)<https://www.purdue.edu/gradschool/diversity/programs/graduate-diversity-vis…>—October 23rd-26th · Will typically host students on Monday, October 24th from 1-2 pm and will need grad students and faculty to meet with them. 3. New Application Deadline Reminder: December 1st Resources, attachments, further information BME PhD Preliminary Exam Announcement for Conner C. Earl (C. Goergen, advisor), Mon., Sept. 19, 3:00 p.m., MJIS 2001 and via Zoom. Everyone is invited to the public presentation from 3:00-4:00 pm. Title: Simplified, Improved, and Automated 4D Cardiac Image Analysis Advisory committee: Craig J. Goergen, Chair; Guang Lin; Vitaliy L. Rayz; Larry W. Markham; Jonathan H. Soslow Abstract: Cardiovascular disease is the leading cause of death worldwide. Cardiac imaging is an increasingly utilized tool to help with early identification and treatment of disease, however as imaging techniques advance in complexity and application, there is a greater need for accessibility and feasibility for clinical and research use. For example, 3D and 4D imaging methods arguably provide a greater morphological and quantitative assessment of cardiac fitness, however these methods also introduce complexity to analysis and interpretation of results. Deep learning for biomedical image segmentation and classification is a promising method that could potentially be used to automate analysis and reduce complexity but requires an informed approach to do so. This proposal builds on previously developed strengths in our lab in using 4D ultrasound to evaluate mouse models of cardiac disease and 4D cardiac magnetic resonance imaging in the characterization of Duchenne muscular dystrophy-associated cardiomyopathy. Using these frameworks, we plan to simplify, improve, and automate 4D cardiac image analysis in both experimental and clinical cardiac image datasets. We hypothesize that these improvements will decrease analysis time of 4D image datasets by more than 90% and that automated image analysis will achieve >95% accuracy for both image segmentation and classification. Achieving these goals will address a growing need in cardiac imaging to provide accessible techniques and technologies to researchers and healthcare providers with the goal of improving cardiac outcomes for patients worldwide. Zoom link: https://purdue-edu.zoom.us/j/91304131947 Auditory Neuroscience at Purdue Talk, Tues., Sept. 20, 4:30-5:30 p.m., LYLE 1017. Sarthak Mangla will speak on “Individualized Hearing Aids.” As a high school student, Sarthak developed a smartphone-based individualized hearing aid along with a remote hearing aid fitting and diagnostics interface. Join us to learn more about his inventions and their potential to further the auditory field. Sarthak is a first-year undergraduate student majoring in Computer Science. Before coming to Purdue, motivated by his grandmother’s experience with hearing loss and hearing aids, he developed an inexpensive smartphone-based individualized adaptive hearing aid using deep learning. He also developed fully automated and remote versions of traditional fitting and diagnostic procedures like Pure Tone Audiometry and Speech Audiometry. He will tell us about his project and work toward individualized hearing healthcare! Weldon School of Biomedical Engineering Distinguished Seminar Series, Wed., Sept. 21, 9:30 a.m. in MJIS 1001 or via Zoom. Peter Caravan, PhD, Professor of Radiology at Harvard Medical School will present “Molecular MR and PET imaging in fibroproliferative diseases.” Abstract: Many chronic diseases have a fibroproliferative component that, if untreated, results in replacement of healthy tissue with fibrotic scar leading to organ dysfunction and ultimate failure. Examples include heart failure, chronic kidney diseases like diabetic nephropathy, chronic liver diseases like NASH, idiopathic pulmonary fibrosis, Crohn’s disease, and scleroderma. Cancers like pancreatic ductal adenocarcinoma also have a fibrotic component. Imaging methods for tissue fibrosis are in general deficient and if available are typically only sensitive to advanced disease. Our lab has been developing molecular probes with MRI or PET imaging reporters to address unmet needs across these disease areas. We are using molecular imaging to address unmet needs in early detection of tissue fibrosis, in noninvasive staging of disease, in measuring disease activity to predict disease progression, and in measuring treatment response. We have also been applying molecular imaging to accelerate therapeutic drug development by measuring drug target expression and target engagement. Since molecular imaging is additive, we have developed multimodal and multiparametric methods for tissue characterization. This lecture will provide examples of these molecular probes and their applications in different models of pulmonary, liver, kidney, and heart disease and in early stage clinical trials. Bio: Peter Caravan, PhD, is co-director of the Institute for Innovation in Imaging (i3) at Massachusetts General Hospital (MGH) and Professor of Radiology at Harvard Medical School. He leads a multidisciplinary and translational molecular imaging lab focused on the invention of novel molecular probes and their broad applications in cardiovascular, pulmonary, renal and hepatic diseases, as well as in cancers. His research spans novel chemistry technologies to advanced MRI and PET imaging in animal models to applications in patient populations. A particular area of focus is imaging in fibroproliferative diseases and the development of new imaging tools for early detection of disease and for measuring disease activity in order to guide treatment. He holds Investigational New Drug (IND) applications for a fibrin-targeted PET tracer and a collagen-targeted PET tracer that are currently being evaluated in 8 clinical trials. Dr. Caravan has invented a general purpose gadolinium-free MRI contrast agent that has been out licensed and is currently in clinical development. He has also invented molecular probes specific to fibrogenesis, acidosis, inflammation and thrombosis. Dr. Caravan received a PhD in Inorganic Chemistry from the University of British Columbia. Following postdoctoral work at the EPFL (Switzerland), he spent 9 years at Epix Pharmaceuticals developing tissue-specific and responsive MRI contrast agents, one of which, gadofosveset, was approved by the FDA and the EMA. He co-founded two companies that are working on commercialization of technology from laboratory. Since joining the MGH in 2007, he has been continuously funded by the NIH. ~BME Faculty Host: Dr. Uzay Emir ~ Zoom link: https://purdue-edu.zoom.us/j/7731446991?pwd=RHdkZTVnRkxTM3J3dnRvY1VLWTlYUT09 (NOTE: Students registered for the seminar are expected to attend in-person.) Purdue Student Soybean Innovation Competition Call-Out, Thurs., Sept. 22, 5:30 p.m., ABE B073. The competition is open to all Purdue students. Registration is OPEN. Team Registration: https://engineering.purdue.edu/ABE/academics/competitions/team_registration Individual Registration: https://engineering.purdue.edu/ABE/academics/competitions/individual_regist… [cid:image006.png@01D8CC1C.3544EDD0] IBSC - BME PhD Preliminary Exam Announcement for Navaporn Sritong (J. Linnes, advisor), Fri., Sept. 23, 2:00 p.m., MRGN 121 and via Zoom. Title: Point-of-care viral molecular detection on paper-based platforms. Everyone is invited to attend the public presentation beginning at 2:00 pm. Committee Members: Jacqueline C. Linnes (Chair), Tamara L. Kinzer-Ursem, Natalia M. Rodriguez, Mohit S. Verma Abstract: Despite the high demand for paper-based point-of-care diagnostics, the limitation in sensitivity is one of the ongoing challenges that can hamper the lab-to-market translation. In this project, I propose to develop 2 detection systems to improve clinical sensitivity and analytical sensitivity of two pathogens: SARS-CoV-2 in saliva and HIV in whole blood. With the surging number of COVID-19 tests, false-negative results have been reported. Integrating internal amplification control (IAC) into an assay can mitigate false-negative due to technical errors. While extensive review papers on paper-based NAATs for SARS-CoV-2 have been published, only a few publications included IAC in their studies. Incorporating IAC on paper-based NAATs is challenging owing to limited one-pot multiplex detection capability on the paper-based platform. Herein, I will develop a one-pot duplex reverse transcriptase loop-mediated isothermal amplification assay by using SARS-CoV-2 as a target and an 18s rRNA in human saliva as IAC on a fully integrated paper-based device. Due to limited sensitivity, existing paper-based rapid diagnostic tests for HIV screening cannot detect a low quantity of p24, viral capsid proteins, in acute HIV infection (AHI). Here, an antibody-initiated loop-mediated isothermal nucleic acid amplification (ai-LAMP) will be developed to offer a novel sensitive platform for AHI. In the presence of p24, viral capsid presenting in the virion in larger quantities than viral RNA, two antibody-partial DNA probes will be in close proximity allowing the completed DNA target to form and trigger the LAMP reaction. The LFIA will be integrated into this design to enable simple result visualization. Zoom link: https://purdue-edu.zoom.us/my/jlinnes Grant Review Sounding Board Meeting, Mon., Sept. 26, 1:00-3:00 p.m., MJIS 3041. RSVP to youngkim(a)purdue.edu<mailto:youngkim@purdue.edu> This is a friendly reminder that our next sounding board for feedback and review of grant ideas will meet on Wednesday, September 26th, 1:00-3:00 pm in MJIS 3041. The NIH submission cycle for R01s is October 5 and November 5 for new and resubmissions. These sessions have been helpful by providing a round of feedback from your peers. Even if you are not submitting this cycle, please join if you are able, to learn about what your colleagues are working on and to provide feedback. Please RSVP to youngkim(a)purdue.edu<mailto:youngkim@purdue.edu>, so we can send you the aims pages for review prior to the start of the meeting. Even if you did not sign up, you are still welcome to attend and get feedback and provide feedback! Please email us your one page aims/objectives the night before so that we could share it with the other members of the research group who will be in attendance. During the meeting, plan to have ~ 3 slides describing: 1. the specific call/agency (you can just cut and paste the RFA onto the slide) 2. your objectives/hypothesis and tasks/aims (concise bullet points) 3. what challenges you are facing and want direct feedback on (also concise bullet points) Also, if this is a resubmission, prepare your response to previous reviews prepared if possible. If you have questions or thoughts, please email youngkim(a)purdue.edu<mailto:youngkim@purdue.edu> BME PhD Preliminary Exam Announcement for Emilee Madsen (J. Linnes, advisor), Wed., Sept. 28, 11:00 a.m., MJIS 2001. This prelim presentation is open only to those who have signed the Lilly NDA. Title: Hydrogel Microneedle Platform for Electrochemical Sensing of Analytes from Interstitial Fluid Committee Members: Dr. Jacqueline Linnes (Chair), Dr. Tamara Kinzer-Ursem, Dr. Lia Stanciu, Dr. Luis Solorio BME PhD Defense Announcement for Catherine Weathered (E. Pienaar, advisor), Fri., Sept. 30, 11:00 a.m., MJIS 2001 and via Zoom. Title: Multiscale Spatiotemporal Modeling for Human Disease: Agent Based Models for Nontuberculous Mycobacterium Infections and Alzheimer’s Disease. Everyone is invited to attend the public presentation beginning at 11:00am. Advisory Committee: Elsje Pienaar, PhD, Chair, Tamara Kinzer-Ursem, PhD, Gregory Knipp, PhD, Patricio Escalante, MD Abstract: Human disease and the corresponding immune response occur in three-dimensional space and time. Many diseases are difficult to study experimentally, either in vivo or in vitro, due to the complexity of the system. Despite computational models that can address complexity, many do not capture the spatial aspects of disease. Agent-based models are mechanistic, spatiotemporal computational models that can be integrated with other mathematical models to create multiscale models. Here I describe two agent-based models used to examine spatiotemporal progression and possible treatment strategies for two diseases with low treatment success: Mycobacterium avium complex (MAC) infection and Alzheimer’s Disease. MAC are biofilm-forming environmental microbes capable of residing in human lung nodules, causing MAC pulmonary disease (MAC-PD). Clinical drug susceptibility tests and treatment outcomes are poorly correlated, and nodules are complex and difficult to monitor, leading to low MAC cure rates (45-65%). I have developed an informative model of the initial bacterial deposition in the lung airway and the resulting host innate immune response in MAC-PD. After characterizing this model, I use it to probe the effects of biofilms and resulting macrophage signaling or changes in the immune system, such as those during menopause. By building a better understanding of these system dynamics on the progression of infection, I can quantify the impacts of immunological or environmental interventions such as upregulating macrophage killing, reducing cytokines, or reducing frequency of bacterial exposure. Alzheimer’s Disease (AD) is the leading cause of dementia, with no disease-altering pharmacological intervention. Microglia are phagocytotic neuroimmune cells, known to form barriers around plaques. There has been increased interest in leveraging microglia to slow the progression of neurodegeneration by manipulating these barriers. I developed an agent-based model of microglia barriers at the single plaque level and use knock-out experiments to probe the role of microglial mechanisms and quantify their effects on plaque progression. This increased understanding can be used for immunotherapy interventions to slow or prevent the progression of AD. Zoom link: https://purdue-edu.zoom.us/j/92267006282?pwd=RVo1Nm82R29OUGovNnlJdVVadkR2Zz… 7th Annual Purdue Institute for Drug Discovery Symposium, Friday, September 30, 9:00 a.m. – 4:30 p.m., Stewart Center Room 218A-D. Keynote speakers include Joseph Schlessinger, Yale University (Cell Signaling by Receptor Tyrosine Kinases; from Basic Principles to Cancer and other Therapies), Gunda Georg, University of Minnesota (Retinoic Acide Receptor Antagonist for Non-hormonal Male Contraception), and Philip Low, Purdue University (A New Generation of Targeted Therapies). Register here: https://purdue.ca1.qualtrics.com/jfe/form/SV_aWQOjeKOgSMQLnU Biomedical Research Associates Group (BRAG) session, Mon., Oct. 3, 10:00-11:00 a.m., MJIS 2001. Dr. Amruta Inamdar, Senior Career Services Consultant at the Purdue Center for Career Opportunities will hold a session titled: "Resume Development for Advanced Degree Candidates.” All BME postdocs and visiting scientists are welcome to attend. This presentation will offer strategies to tailor your experience for the industry job(s) you are applying for. Please bring your current CV and a job posting that you are interested in (even if you are not actively on the job market) as we will have time to workshop material. Coffee + snacks will be served. RSVP (via Outlook link or directly to Kaisa Ejendal at kejendal(a)purdue.edu) before September 26. That way, I can invite senior graduate students to reach the required attendee number for the session. (BRAG has priority) BMES 2022 Annual Meeting will be held in San Antonio, Texas on October 12-15, 2022. Registration is now open! Register here: https://s7.goeshow.com/bes/annual/2022/attendee_reg.cfm Special BME Seminar, Wed., Oct. 19, 9:30 a.m. in MJIS 1001 and via Zoom. Megan Yi-Ping Ho, PhD, Associate Professor of Biomedical Engineering at The Chinese University of Hong Kong will present “Microfluidics for Single Cell Applications.” Abstract: Microfluidics has gathered significant interest for biomedical applications, particularly the analysis of targeted biomolecules from minute amount of samples. This presentation will summarize our efforts on exploiting microfluidics for the manipulation and analysis of individual cells and subcellular organelles. In particular, we have explored the possibility of modulating hydrodynamic shear stress at microscale to selectively disrupt cellular membrane while maintaining the mitochondrial membrane intact. We have also investigated a microfluidics-based method to encapsulate protein payloads into red blood cells by controlling membrane deformation either transiently or extendedly in a microfluidic channel. This presentation will also highlight our recent development of a novel surfactant based on fluorinated plasmonic gold nanoparticles, rendering a previously unavailable feature of photo-responsiveness in droplet microfluidics. Looking forward, we plan to study the fundamentals of how individual cells alter their phenotypes in response to environmental and therapeutic stimuli. These efforts are expected to find clinical applications in diagnostics, prognostics and treatment evaluation of infectious and chronic diseases, as well as to expand our fundamental understanding towards disease development. Bio: Megan Yi-Ping Ho is currently an Associate Professor in the Department of Biomedical Engineering at the Chinese University of Hong Kong. She received her B.S. and M.S. in Power Mechanical Engineering from National Tsing-Hua University, Taiwan. She received her Ph.D. in Mechanical Engineering from the Johns Hopkins University in USA. After her postdoctoral training with Duke University in USA, she received the Young Elite Researcher Award from the Danish Research Council for Independent Research and started her independent career in the Interdisciplinary Nanoscience Centre and the Department of Molecular Biology & Genetics at Aarhus University in Denmark. She is a co-founder of two start-up companies situated in Demark, Zymonostics and vPCiR, focusing on enzyme-based diagnostics. She has published 67 peer-reviewed journal articles, 6 book chapters, 77 conference papers, edited 1 book and holds 2 granted patents. The results that she presented have been recognized internationally by the American Society of Gene Therapy and Controlled Release Society. Her research team is focused on developing nanosensors and microfluidics as diagnostic tools to expand the capacity of disease detection and treatment evaluation. ~BME Host: Young Kim~ Zoom link: https://purdue-edu.zoom.us/j/7731446991?pwd=RHdkZTVnRkxTM3J3dnRvY1VLWTlYUT09 Attachments BME Core Values BME Seminar Schedule Fall 2022 PIDD Symposium Sessions Student Showcase Flyer WL-Indy Collaboration Individual Development Plan AerospaceCorp Tech Talk AerospaceCorp Lobby Day -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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BME PhD Preliminary Exam Announcement for Emilee Madsen (J. Linnes, advisor)
by May, Sandra M 19 Sep '22

19 Sep '22

This prelim presentation is open only to those who have signed the Lilly NDA. BME PhD Preliminary Exam Announcement for Emilee Madsen (J. Linnes, advisor) Title: Hydrogel Microneedle Platform for Electrochemical Sensing of Analytes from Interstitial Fluid Date: September 28, 2022 Time: 11:00 AM EST Location: MJIS 2001 Committee Members: Dr. Jacqueline Linnes (Chair), Dr. Tamara Kinzer-Ursem, Dr. Lia Stanciu, Dr. Luis Solorio

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Save the Date: Fall Faculty Coffee Chats
by Siemers, Tammy R 16 Sep '22

16 Sep '22

Happy Friday! We are once again hosting are faculty coffee chats for grad students. Remember, we need attendance for this event to be successful so get these on your calendars today😊. These coffee chats will attempt to accomplish some priorities that have been shared with us by you: 1. First year students—what a great opportunity to find out more about other labs and find potential mentors for your qual committee. 2. Grad student professional development—to learn/ask/chat about topics of interest to the student either about research or other topics. 3. Increase faculty involvement with graduate students outside of their own lab. 4. Help build community between grad students. Here are the dates and faculty for fall October Date: October 3rd Time: 9:30-10:30 am Location: MJIS 2041 Faculty host: Eugenio Culurciello Potential discussion topics: startups commercialization, digital health, health equity November Date: November 10th Time: 9:30 am-10:30 am Location: MJIS 3041 Faculty hosts: Hugh Lee, Taimoor Qazi, Steve Steinhubl Potential discussion topics: ask me anything/healthcare, academic jobs/academia, visas/international students December: Date: December 8th Time: 2:00 pm-3:00 pm Location: MJIS 2041 Faculty host: Deva Chan Potential discussion topics: AMA work-life, teaching & diversity statements, time management Please plan to participate in as many as your schedule will allow. There will be free snacks and drinks included. I will also send out calendar invites for those of you who utilize them. Tammy Tammy Siemers Senior Graduate Training Program Administration and Professional Development Specialist Weldon School of Biomedical Engineering 206 S. Martin Jischke Drive, West Lafayette, IN 47907-2032 o: 765-496-0294 Achiever, Relator, Includer, Restorative, Developer [233FFCD4]<https://www.purdue.edu/?utm_source=signature&utm_medium=email&utm_campaign=…>

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ANAP Talk--Individualized Hearing Aids
by Siemers, Tammy R 16 Sep '22

16 Sep '22

Join ANAP for a talk by Sarthak Mangla on his work developing his hearing aid software. Sarthak is a first-year undergraduate student majoring in Computer Science. Before coming to Purdue, motivated by his grandmother's experience with hearing loss and hearing aids, he developed an inexpensive smartphone-based individualized adaptive hearing aid using deep learning. He also developed fully automated and remote versions of traditional fitting and diagnostic procedures like Pure Tone Audiometry and Speech Audiometry. He will tell us about his project and work toward individualized hearing healthcare! Location - LYLE1017 Date - September 20, 2022 Time - 4:30 to 5:30 pm

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TONIGHT: Catalent Info-Session & Networking Opportunity
by Siemers, Tammy R 15 Sep '22

15 Sep '22

[cid:image005.png@01D8C909.D0ACE4F0] September 15 | 6:00 - 7:30pm Purdue University ARMS 1103 [cid:image006.png@01D8C909.D0ACE4F0] Apply now & stay connected by joining our Talent Community at careers.catalent.com.

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[Bmeroundtable-list] MJIS ALERT: Air handling
by Gelfand, Johanna K 15 Sep '22

15 Sep '22

Bearings are being replaced on one of the MJIS building fans. This will be an all-day project. You will hear loud noises, and air handling will be up and down, but major building functions should not be affected. Thank you for your continued patience and understanding! Susan Hardy Hardy13(a)purdue.edu -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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