February 2022 - Bmegradstudents-list

[Bmeroundtable-list] Change to virtual only: IBSC BME Preliminary Exam Announcement for Edmond Rogers (R. Shi, advisor)
by Gelfand, Johanna K 09 Feb '22

09 Feb '22

Please note this preliminary exam will now be held virtually ONLY. IBSC BME Preliminary Exam Announcement for Edmond Rogers (R. Shi, advisor) Research Title: Elucidating Pathological Correlations between Traumatic Brain Injury and Alzheimer's Disease Committee Members: Major professor: Riyi Shi Members: Joseph Rispoli, Fang Huang, GuangJun Zhang Date/Time: Thursday February 10th at 10am *NEW* Location: https://purdue-edu.zoom.us/j/94760432982 (No in person meeting in MJIS 2001.) Abstract: One of the greatest consequences of Traumatic Brain Injuries (TBI) are the resulting long-term effects, especially in milder cases where the damage is initially subclinical and thus lacking acutely observable manifestations that can compound significantly over time. Among these chronic issues, Alzheimer's Disease (AD) is one of the most serious. While a link between TBI and AD has been established, it has not yet been mechanistically elucidated. Multiple hypotheses have been postulated based on various animal/clinical models, which have contributed a great deal to our knowledge base and implicated several key pathways. While extremely valuable, these in vivo procedures and analyses are physiologically and ethically complex: there is currently no model capable of visualizing TBI-induced sub-cellular damage in the seconds immediately following injury, and the subsequent associated long-term changes. It is clear that additional investigative tools are needed, and while in vitro methodologies generally offer the type of resolution required, no such model replicates this phenomenon. Therefore, we introduce the "TBI-on-a-chip" concussive model prototype, with a series of concomitant targeted-experiments to address this currently unmet need. We hypothesize that both the primary, mechanical injury and long-term associated damages (secondary injury) can be successfully recapitulated in vitro, and utilized for mechanistic studies into trauma induced neurodegeneration. Further, we hypothesize that aggregation (β-amyloid) can be initiated by force-solo and demonstrated in our proposed system, further linking TBI with AD. Our ultimate goal is to facilitate translational discoveries by exploring the mechanisms underpinning TBI, acute and chronic, and the link to neurodegeneration. -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME Monday Roundtable - 2/7/2022
by Gelfand, Johanna K 07 Feb '22

07 Feb '22

[cid:image001.png@01D81C06.D6279750] BME MONDAY ROUNDTABLE February 7, 2022 HEAD MESSAGE Dear Weldon School, Two Faculty candidates this week! Please continue to participate in the faculty candidate seminars! We will have several candidates over the next 3-4 weeks. Area chairs- please remind your area to review the website and take notes for updates that are needed. PROTECT PURDUE * Masks are still required! https://protect.purdue.edu/required-covid-19-protocols/ * Vaccines are strongly encouraged (though not required) https://protect.purdue.edu/vaccine-information/ * Updated guidance came out on Jan 7- for research SOPs, etc. and Protect Purdue. Please make sure you are staying current with Purdue guidelines. UPCOMING IMPORTANT DATES Week of Feb. 7 Mon., Feb. 7 – Prospective BME Faculty Seminar: Nancy Xu, “New NanoBiotechnology for Sensing and Imaging of Single Live Cells: From Fundamental Discoveries to Biomedical Innovations,” 9:30 a.m., MJIS 1083 and via Zoom: https://purdue-edu.zoom.us/j/95097354421?pwd=VHVHZGRLb21TVnNlczhEY2dKTjZKUT… Tues., Feb. 8 – IBSC BME Preliminary Exam Announcement for Mazin Hakim (L. Solorio advisor), 2:00 p.m., MJIS 2001. Please note this prelim is open only to those who have signed the Lilly NDA. Wed., Feb. 9 – Prospective BME Faculty Seminar: Mehdi Javanmard, “Electro-Fluidics for Health and Environmental Monitoring,” 9:30 a.m., MJIS 1001 and via Zoom: https://purdue-edu.zoom.us/j/95150439811?pwd=a3hOK0o0bmpkS3poTVBCbVhDNU9FZz… Wed., Feb. 9 – BME Bytes Seminar, 1:30 pm, Location MJIS 1083. Presenter: Sarah Libring. “Using Fibronectin-Based Drug Screening Platforms for Precision Medicine of Metastatic Breast Cancer Patients.” Open to all undergraduate and graduate researchers. Lunch will be provided. Wed., Feb. 9 – Seminar for Neurotrauma and Disease, 4:00-5:00 p.m. via Zoom: https://bit.ly/3tDZOfm, “Nature’s Unifying Theories and How They Can Be Used for Good,” Philip LeDuc, PhD., William J. Brown Professor of Mechanical Engineering, Carnegie Mellon University Thurs., Feb. 10 – IBSC/BME Preliminary Exam for Edmond Rogers (R. Shi, advisor) from 10 am-noon, MJIS 2001. Research title: “Elucidating Pathological Correlations between Traumatic Brain Injury and Alzheimer’s Disease” Fri., Feb. 11 – BME PhD Defense for John G. Damrath IV (J. Wallace, advisor) from 11 am-noon, Joseph E. Walther Hall, Room C203 (IUPUI) and via Zoom: https://iu.zoom.us/j/81801089129, Meeting ID: 818 0108 9129. Research title: “Multiscale Characterization of Skeletal Properties in Diabetes and Chronic Kidney Disease” Upcoming important deadlines and info. Mon., Feb. 14 – Thurs., Feb. 17 – Fulbright Week Info Sessions. See attached flyer. Tues., Feb. 15 – Nomination deadline for excellence in PhD graduate student research. See details below. Tues., Feb. 15 – Nomination deadline for COE Outstanding Service Scholarship. See details below. Wed., Feb. 16 – BME Bytes Seminar, 2:00 pm, MJIS 1083. Presenter: Jen Anderson. Open to all undergraduate and graduate researchers. Lunch will be provided. Wed., Feb. 16 – BRAG Event, 2:00 p.m., MJIS 2001. Drs. Vitaliy Rayz and Luis Solorio will host a Q&A on the topic “Writing a successful NIH postdoctoral (K99/K25) grant: Advice and insights from previous awardees and reviewers” Tues., Feb. 22 – Preclinical Innovation of Biomedical Translational Research: Indiana Clinical and Translational Science (CTSI) Virtual Retreat from 10AM - 3:30PM Eastern. Wed., Feb. 23 – BME Bytes Seminar, 1:30 pm, Location TBD. Presenter: Angel Enriquez. Open to all undergraduate and graduate researchers. Lunch will be provided. Wed., Feb. 23 – Thurs., Feb. 24: Fourth Annual Conference for Associate Professors, sponsored by Susan Bulkeley Butler Center for Leadership Excellence, Purdue University (see below) Thurs., Feb. 24 – Sat., Feb. 26: Admissions Open House visit—planning for hybrid (virtual and in-person) event Mon., Feb. 28 – Deadline to submit a poster to the Graduate School’s Office of Interdisciplinary Graduate Programs (OIGP) for their annual Spring Reception honoring interdisciplinary graduate student research. Details below. Mon., Feb. 28 – Deadline to register for Graduate Faculty Mentoring Workshop through the Graduate School. Details below. Fri., Mar. 4: Coffee Chat with Faculty: 11:00 am-noon, Location TBD. Faculty host: Nan Kong. Potential discussion topics: academic job search, initiate multi-disciplinary research, make social impact with your research Wed., March 9 – BME Bytes Seminar, 1:30 pm, Location TBD. Presenter: Antonia Susnjar. Open to all undergraduate and graduate researchers. Lunch will be provided. Thurs., Mar. 10: Coffee Chat with Faculty: 4:00 pm-5:00 pm, Location TBD. Faculty host: Elsje Pienaar. Potential discussion topics: time management, teaching and diversity statements, work/life balance; imposter syndrome Wed., March 23 – BME Bytes Seminar, 1:30 pm, Location TBD. Presenter: Luke Brennan. Open to all undergraduate and graduate researchers. Lunch will be provided. Wed., March 30 – BME Bytes Seminar, 1:30 pm, Location TBD. Presenter: Mazin Hakim. Open to all undergraduate and graduate researchers. Lunch will be provided. Wed., April 6 – BME Bytes Seminar, 1:30 pm, Location TBD. Presenter: Tommy Jenkins. Open to all undergraduate and graduate researchers. Lunch will be provided. Fri., Apr. 8: Coffee Chat with Faculty: 11:00 am -12:00 pm, Location LYLE (Room TBM). Faculty hosts: Mike Heinz and Hari Bharadwaj. Potential discussion topics: writing grants (fellowships), talking to a lay audience, open science, academic job interviews/negotiating Wed., April 20 – BME Bytes Seminar, 1:30 pm, Location TBD. Presenter: Apekshya Chhetri. Open to all undergraduate and graduate researchers. Lunch will be provided. Thurs., May 5: Coffee Chat with Faculty: 11:00 am -12:00 pm, Location LYLE (Room TBM). Faculty host: Alexandria Volkening. Potential discussion topics: website development, public science and outreach, social media, academic job materials (with an interdisciplinary perspective) Upcoming prospective faculty seminars. Mon., Feb. 7 – Prospective BME Faculty Seminar: Nancy Xu, “New NanoBiotechnology for Sensing and Imaging of Single Live Cells: From Fundamental Discoveries to Biomedical Innovations,” 9:30 a.m., MJIS 1083 and via Zoom: https://purdue-edu.zoom.us/j/95097354421?pwd=VHVHZGRLb21TVnNlczhEY2dKTjZKUT… Wed., Feb. 9 – Prospective BME Faculty Seminar: Mehdi Javanmard, “Electro-Fluidics for Health and Environmental Monitoring,” 9:30 a.m., MJIS 1001 and via Zoom: https://purdue-edu.zoom.us/j/95150439811?pwd=a3hOK0o0bmpkS3poTVBCbVhDNU9FZz… Mon., Feb. 14 – Umut Gurkan, 9:30 a.m., MJIS 2001 and via Zoom Mon., Feb. 21 – Craig Forest, 9:30 a.m., MJIS 1083 and via Zoom SPRING 2022 BME Faculty Meetings All faculty meetings will begin at 11:30 a.m. in MJIS 2001 Fri., February 11 Fri., March 25 Fri., April 22 SPRING 2022 BME Primary Committee Meetings Fri., March 4, 11:30-1:00, MJIS 2001 Fri., April 15, 10:00-5:00, MJIS 2001 (LONG meeting!) Committee Updates Academic Programs Accommodating student disability requests: As instructors we are on the front line of creating instruction and course delivery that provide equitable and inclusive access to a Purdue education. Disability is an aspect of diversity that is integral to our society and to the Purdue campus community. It takes a lot of courage for students to ask for accommodation in the classroom. It is our responsibility to treat each request with respect. A rejection can be quite detrimental to the student, as well as being in violation of the Americans with Disabilities Act. If you need assistance accommodating disability request, the Purdue Disability Resource Center is an important campus resource that collaborates with faculty, students, and staff to create usable, equitable, inclusive, and sustainable learning environments. https://www.purdue.edu/drc/faculty/index.php As we are several weeks into the semester, you should have already received accommodation requests from your students and received an “Aggregate Report” from DRC of what curricular accommodations are expected to be requested. Most questions about accommodations can be answered informally through discussion with DRC staff: drc(a)purdue.edu<mailto:drc@purdue.edu>. Graduate Admissions (****TIME SENSITIVE****): * Recruiting season is upon us. Please be proactive about talking to candidates to build rapport and to increase our recruiting pool. * In lieu of extensive research area introduction, we will have a virtual “meet-the-faculty” meeting in Dec to finalize the in-person visitation list. * This is an optional event. * It will be live for invited (applied) students to meet you but could be pre-recorded (i.e., CoE Showcase event that happened before) to introduce your lab. * The premise is to increase our touchpoints with candidates. * We are looking to revive the “Science on Tap” event during our open house. * So we need a volunteer speaker! * We hear it’s a great exposure and highly recommended (by Maria!) Graduate Programs – update The Graduate School will be hosting two Graduate Faculty Mentoring Workshops in West Lafayette this spring. The first will be on Wednesday, March 9, 2022 from 9:00 a.m. to 11:30 a.m.; and the second will be on Thursday, March 10, 2022 from 9:00 a.m. to 11:30 a.m. Both workshops will be held at the Stewart Center in Room 202 unless we have to move to virtual. The workshop provides an overview to the policies, procedures and expectations associated with mentoring graduate students at Purdue University. Participation in the workshop is required for any faculty member who wishes to seek appointment to the Graduate Faculty at Purdue University. Historically it has been the practice of the Graduate School to require faculty new to Purdue to attend a Graduate Faculty Mentoring Workshop before they could obtain graduate faculty status. While a practice, it is not “policy” so we will not hold up faculty appointments due to logistics of when the workshops are offered. This does not negate the request for faculty new to Purdue to attend one of the new faculty workshops, but it does mean the Graduate School will not hold an appointment request based on workshop completion. In addition to attending one of these two workshops, faculty who wish to hold a position as a regular member of the Graduate Faculty must also be recommended by their unit and be a tenure-track or voting status faculty member. This process must be initiated in the Graduate School Database, and is typically done by the department graduate contact. Appointment to the graduate faculty permits a faculty member to teach graduate-level courses, to serve on graduate student advisory committees, and to chair or co-chair master’s and Ph.D. committees. The level of appointment is dependent upon the faculty member’s position, rank and credentials. Graduate coordinators and contacts - Please provide faculty members the instructions below to register online. I will also still accept email registrations if there are any complications but my preference would be to direct them to use the electronic system. It is very important that participants arrive on time and do not leave early. Missing part of the presentation could cause their attendance to not count toward fulfilling the requirement needed to advise students or become a regular faculty member. Please make sure that he registering faculty members are aware of this. To register for one of the workshops, please go to the following link and complete the Qualtrics survey GradFacultyWkshp2022<https://purdue.ca1.qualtrics.com/jfe/form/SV_3lPEgXEbrU2Aej4> or copy and paste the following link into your browser: https://purdue.ca1.qualtrics.com/jfe/form/SV_3lPEgXEbrU2Aej4 Deadline for registration is Monday, February 28, 2022. Additional workshops (including workshops on regional campuses) will not be held until September 2022. If you have any additional questions, please do not hesitate to contact me Casey Hollingsworth Executive Assistant to the Dean | The Purdue University Graduate School She/her/hers Young Hall, Room 169 | 155 S. Grant Street | West Lafayette, IN 47907 o: 765-494-2604 | chollingsworth(a)purdue.edu<mailto:chollingsworth@purdue.edu> Life Sciences The Purdue Lecture Hall Series Dear all, I would like to send out a broad invitation to graduate students conducting life science research to present their work for “The Purdue Lecture Hall Series”. This is a program where graduate students present their experience and journey into the world of research to undergrads and high school science students who are interested in learning more about life sciences research and how they can get started. We are looking for dynamic presenters and investigators that want to engage their audience and inspire a new generation on scientists. If you or someone you know is interested in participating, please have them reach out to Robin Benson benson75(a)purdue.edu<mailto:benson75@purdue.edu>. Best regards, Thomas G. Sors, PhD Assistant Director Purdue Institute of Inflammation, Immunology and Infectious Disease * Individual Development Plans (IDPs). Please find attached IDP forms for BME. The graduate committee wants all of our trainees/students to use IDPs throughout their career with us. These forms are intended to be student initiated and then reviewed AND DISCUSSED with faculty mentors and ideally mentoring/thesis committees. Again, our forms are just helpful templates – any forms you find that you like are OK to use as an IDP. * Launching Coffee Chats THIS SEMESTER. To facilitate more interactions between students and faculty outside their own lab, we are launching a new initiative. 1-2 faculty members will host coffee chats each month to discuss anything that is on the students’ minds (some starter topics are suggested for each meeting, but really anything is on the table.). There is a lot of excitement about this initiative from our students, as well as from the Graduate Committee – we look forward to the first coffee chat in early February. * January is Mentoring Month!! The MOST CONSISTENT THEME that has come out of our systematic Grad-Programs review has been the need for better and more consistent mentoring throughout our student’s graduate programs. Links are provided in the DEI section to several excellent programs (including the NIH webinar series on RAISING A RESILIENT SCIENTIST<https://www.training.nih.gov/workshops_and_trainings_for_extramural_princip…> that was mentioned in faculty meeting on Friday). * Systematic Grad Programs Review and Update: We continue this important work for our students. The goal is to have a broad framework for changes/updates to milestones and mentoring structure by February for implementation starting in Fall 2022. We started with strategic planning to define the desired outcomes for the design of our Training Program. We have reviewed data from current students, graduating students (exit interviews), faculty, head-search survey, DEI survey, Ology Marketing report, and committee-gathered data from other BME programs’ milestone structures. These discussions have led to many great ideas, which we are just now starting to map to our desired learning outcomes across the length of the PhD program to develop a new plan for the most effective milestones/requirements and support systems to achieve our vision for the training program. Stay tuned for updates, and solicitations for feedback. As always, please talk with any member of the Graduate Committee at any time if you have ideas/suggestions/concerns. Later this spring we will begin discussions on improvements to the graduate curriculum. Thanks for your support. Undergraduate Curriculum Committee Update In Spring 2022, the UCC will continue working on introducing BME pathways. The UCC will request each Research Area to present the corresponding Pathway to sophomore students in the next month. This will help the students to decide on their area of specialization. The presentation should clarify the knowledge and skills the students would gain as well as the future career opportunities for each BME Pathway. The UCC will also work on developing the Engineering Design courses for the re-structured undergraduate program, including the Junior and Senior Design and professional development courses. The committee will create a task force for collecting benchmark data on curriculum redesign for the future ABET accreditation. Also, the UCC will work on increasing our offering of honors courses or honors sections within courses. DEI Committee Update February is Black History Month 2022 National Theme is Black Health and Wellness. According to the Association for the Study of African American Life and History which sets the annual focus, "This theme acknowledges the legacy of not only Black scholars and medical practitioners in Western medicine, but also other ways of knowing (e.g., birthworkers, doulas, midwives, naturopaths, herbalists, etc.) throughout the African Diaspora. The 2022 theme considers activities, rituals and initiatives that Black communities have done to be well." learn more at: https://asalh.org/black-history-themes/ Purdue's celebrations of Black excellence this month can be found at: https://lifeat.purdue.edu/black-history-month/ January is Mentoring Month The Graduate Student Peer Mentoring groups are running again this semester and new first years have now been paired up with senior students. Grad students and postdocs please reach out to BMEGSA leaders Angel Enriquez (aenrique(a)purdue.edu<mailto:aenrique@purdue.edu>) and Claudia Benito Alston (cbenitoa(a)purdue.edu<mailto:cbenitoa@purdue.edu>) if you want to get involved as a mentor or a mentee. * The scheduled mentor/mentee meeting days are: 11-1pm on January 28th, February 18th, March 11th, April 8th, May 13th BMES Undergraduate Peer mentoring is also getting underway and sophomores have the opportunity to participate in a mentoring group led by 1-2 upper classmen or in individual mentoring pair with a more senior student. Mentors and mentees participate in one large group and a small-group or meeting as a pair each month. Resources for Mentoring Webinars: NIH RAISING A RESILIENT SCIENTIST<https://www.training.nih.gov/workshops_and_trainings_for_extramural_princip…> series for faculty and administrators who mentor students and postdoctoral fellows Mentoring at Purdue (M@P): network and resources<https://www.asec.purdue.edu/map/index.cfm#Resources> for mentors and mentees Podcast: The Science of Effective Mentoring in STEMM<https://www.nationalacademies.org/our-work/the-science-of-effective-mentori…> from the National Academies National Research Mentoring Network<https://nrmnet.net/> open to all career stages Winter Warming Station Meal Sign up<file:///C:/Users/dumulis/Library/Containers/com.apple.mail/Data/Library/Mail%20Downloads/51FC69A6-C178-4415-BF4A-CAFB01D5DCC8/Winter%20Warming%20Station> Lafayette Urban Ministry (LUM) – Meals are needed each day Nov 15 through Apr 15. Business Services Updates Going forward, Purdue Travel has been restructured in order to assist with the Concur expense report process for employees who travel. Please see the below update on the new process and contact information for questions: Purdue Travel will provide all employees with a central, convenient way to submit travel receipts and business mileage, and then compile the travel expense report on the traveler’s behalf. With this change, there is now a team dedicated to the creation of expense reports. Based on a completed pilot program, the centralization of travel expense reports is expected to significantly reduce the time to create an expense report and reimburse the traveler to just four to seven days. By transitioning this work to dedicated Purdue Travel staff, employees will have more time to focus on their core responsibilities. All employees or their delegates will need to submit expenses for reimbursement using one of the following methods upon returning from business travel: * Add business expense receipts to the receipt store in the Concur mobile app. If travel was booked through Concur or Anthony Travel, Purdue Travel will reach out to the traveler/delegate to initiate the expense report process. * Attach business expense receipts in an email to purduetravel(a)purdue.edu<mailto:purduetravel@purdue.edu>. Travelers or their delegates must initiate this process on their own by emailing the receipts. A list of required information and documentation<https://www.purdue.edu/procurement/travel/expenses/index.php> is available on the Travel website under the “Expense Reimbursement” header. For business mileage reimbursement to Purdue employees, either of the above processes may be used. The traveler will need to provide a copy of their mileage log or screenshots showing the distance of business mileage traveled (e.g., using Google Maps). The traveler also must provide the reason for travel in the comment box in Concur or in the email to purduetravel(a)purdue.edu<mailto:purduetravel@purdue.edu>. The Purdue Travel website has been updated to reflect the changes to travel expense reports<https://www.purdue.edu/procurement/travel/expenses/index.php>. Additional information and resources will be added as they become available. Questions may be directed to Purdue Travel at 765-494-7354 or purduetravel(a)purdue.edu<mailto:purduetravel@purdue.edu>. Resources, attachments, further information BME Prospective Faculty Seminar - Monday, February 7, 9:30-10:20am, MJIS 1083 or Via Zoom: https://purdue-edu.zoom.us/j/95097354421?pwd=VHVHZGRLb21TVnNlczhEY2dKTjZKUT… “New NanoBiotechnology for Sensing and Imaging of Single Live Cells: From Fundamental Discoveries to Biomedical Innovations,” presented by X. Nancy Xu, PhD, Professor in Biomedical Engineering, Biomedical Sciences, Biochemistry, and Chemistry, Old Dominion University Abstract: Single cells are building blocks of all living organisms. Understanding of functions of individual live cells and their communications is essential to rationally design and engineer effective diagnosis and therapies. New tools for detecting and targeting specific individual cells would revolutionize disease diagnosis and treatments. Single live cells also offer unique inspiration for rational design and engineer biocompatible smart materials and devices for bioengineering innovation (e.g., self-powered, self-repaired, self-assembled, self-replicated “live” robots). To achieve these transformative potentials, it is crucial to depict how individual live cells function and communicate to enable specific functions in cell culture, tissues, live animals, and ultimately in human in real time at single-cell and single-molecule resolutions. Interactions of couples of molecules in single live cells can induce a cascade of vital cellular responses and alter cellular and tissue functions. Current tools are unable to real-time study molecular machineries of single live cells with adequate quantitation, spatial and temporal resolutions and over a desired long period of time. We have pioneered the development of a set of powerful new technologies, including photostable single plasmonic nanoparticle imaging probes, single molecule nanoparticle optical biosensors (SMNOBS), and far-field photostable optical nanoscopy (PHOTON). We have demonstrated that these new tools can overcome the drawbacks of fluorescence-based imaging platforms for dynamic, single molecule and multiplexing imaging of single live cells with superior temporal and spatial resolutions and over a long period of time (hours, days, weeks). We have used these new tools to real-time study: (i) molecular cascades of signaling transduction pathways of single live cells; (ii) molecular mechanisms of multidrug resistance of single live cells; (iii) efficacies of single drug nanocarriers; (iv) native environments of developing embryos and differentiation of embryonic stem cells into cardiomyocytes and neurons; and (v) rare subsets of single cancer stem cells (CSCs) in clinical tissues for exploring new paradigm of early cancer detection and targeted therapy. We are currently developing new nanobiophotonic sensing and imaging platforms for real-time large-scale recording and modulation of neuron-neuron communicates, aiming to understand how brain develops and functions and how to effectively detect, diagnose and treat brain diseases. In this seminar, I will describe these new nanobiotechnologies and their innovative biomedical engineering applications. The work was supported by NIH and NSF. [cid:image002.png@01D81C06.D6279750] Bio: Dr. X. Nancy Xu is the AAAS Fellow and Professor of Biomedical Engineering, Biomedical Sciences, Biochemistry, and Chemistry at Old Dominion University (ODU). During her tenure at ODU, Dr. Xu has built a state-of-the-art interdisciplinary research laboratory, and successfully developed a nationally and internationally recognized and well-funded interdisciplinary research program at the interface of chemistry, biology, engineering, and medicine. Dr. Xu has successfully directed NSF and NIH funded interdisciplinary research programs and she has demonstrated a track-record of accomplishments in successfully competing for highly prestigious federal research grants, including NSF NIRT, NSF BRAIN Initiative, NIH R01, and DoD MURI awards. Dr. Xu has pioneered the development of a set of powerful new sensing and imaging technologies for biomedical applications. She is especially well recognized for her pioneering work in single nanoparticle optics, single nanoparticle plasmonic spectroscopy, single molecule sensing, and single live cell imaging. Dr. Xu holds a world-wide patent on DNA Biosensors and has consistently published her work in high-impact peer-reviewed journals. Dr. Xu has led and developed several new graduate and undergraduate courses and she has taught 26 different courses on various topics including biosensing, imaging, biomedical sciences, biomedical engineering and nanobiotechnology. Dr. Xu has served as an expert reviewer and panelist for 15 national and international funding agencies, 62 NIH grant review panels and 26 NSF grant review panels. Dr. Xu has led and served as a track director/coordinator for an interdisciplinary joint PhD program in Biomedical Sciences between ODU and Eastern Virginia Medical School. and as the member of advisory board of Frank Reidy Research Center for Bioelectrics. Dr. Xu has received several prestigious national awards (e.g., Nano 50 Innovator Award, Nano 50 Technology Award, NSF BRAIN Initiative EAGER Award, Finalist of NIH Follow That Cell Challenge, ACS Roland F. Hirsch Award, and AAAS Mentor Award) and university awards (e.g., Distinguished Research Award, Faculty Research Achievement Award, University Presidential Diversity Champion Award, student-nominated Shining Star Recognition and Most Inspired Faculty Member Designation). Dr. Xu received her B.S. from Xiamen University and her Ph.D. from the University of Mississippi. She was a postdoctoral fellow at the University of Texas at Austin and Ames Lab-Iowa State University. Her profile is at www.odu.edu/~xhxu<http://www.odu.edu/~xhxu>. Fulbright Week Info Sessions - The Fulbright application process for the U.S. Student Program kicks off. Please put this slide up in your classes (or share screen on Zoom, insert in your PPT) next week (Feb 7 – 11), to advertise before Purdue’s National and International Scholarships Office (NISO) Fulbright information sessions the following week. Sessions are simultaneously virtual and in person. For the first time in Purdue’s history, Purdue is a 2021-22 Fulbright U.S. Student Program Top Producer. This means all of this university’s work toward Fulbright have positioned Purdue University nationally. Thank you! Talking points if you need them: · Fulbright U.S. Student Program is the US’s premier program for international research, teaching, and cultural exchange. Its reputation is for funding the best of US scholars · This is a grant, not a scholarship; and no glorified study abroad experience. It’s living for a year in one of over 140 countries to conduct research in your field, earn an advanced degree, or teach English · English Teaching Assistantships have you teach part time and spend the rest in “cultural engagement” of your own devising. ETAs might go on to jobs, med school graduate school . . . · Graduate schools and industry will often defer offers for a year because Fulbright experience is coveted · Approx 50% of recipients are undergrads or recent alumni when they apply and 50% graduate students · Those who already had a taste of the good life when abroad often apply successfully for Fulbright as a funding opportunity for more and deeper experience · Fulbright also has a special place in its heart to fund those who have never spent time abroad · Fulbrighters are independent and creative, and excited to go to their prospective host country · It is a post-baccalaureate year · First and second year students attend Fulbright Week to find out what to aim for in order to be purposeful in their undergraduate experience; · Third and fourth year students as well as graduate students and recent alumni begin applying now for a 2022-23 grant. More information can be found on our Fulbright Week page<https://www.purdue.edu/niso/fulbright/fulbrightweek.html> where you will find the full schedule, session descriptions, and a digital flyer to download from the left sidebar. You will also find RSVP links and a WebEx address for students off campus to remote into the session. There is an information session for faculty interested in applying to the Fulbright U.S. Scholars<https://cies.org/> program. It’s not on the slide, but that session withChris Lukasik<https://www.cla.purdue.edu/directory/profiles/christopher-lukasik.html> is Monday, 3:30 – 4:30pm in WALC 3138. IBSC BME Preliminary Exam Announcement for Mazin Hakim (L. Solorio advisor), Tues., Feb. 8, 2:00 p.m., MJIS 2001. Please note this prelim is open only to those who have signed the Lilly NDA. Title: Platforms for Molecular Mechanisms and Improvement in Subcutaneous Injection of Biotherapeutics Advisory Committee: Luis Solorio, Chair Arezoo M. Ardekani Julie C. Liu Pavlos P. Vlachos BME Prospective Faculty Seminar – Wednesday, February 9, 2022, 9:30-10:20am, MJIS 1001 or Via Zoom: https://purdue-edu.zoom.us/j/95150439811?pwd=a3hOK0o0bmpkS3poTVBCbVhDNU9FZz… “Electro-Fluidics for Health and Environmental Monitoring,” Mehdi Javanmard, Ph.D., Associate Professor of Electrical & Computer Engineering, Rutgers University Abstract: In this talk, I will discuss my group’s work on fabricating micro- and nanosensing platforms for health and environmental monitoring. In the first part of my talk, I will discuss the fabrication of novel electronic sensing modalities both in vitro and in vivo and the role they can play in electroceutical applications for monitoring chronic inflammatory illnesses, wounds, and infectious diseases. I will also discuss domain specific use of machine learning to enable data-driven biosensors for improvement in accuracy and specificity. Finally, I will talk about my group's work in environmental monitoring. Bio: Mehdi Javanmard is an Associate Professor in the Electrical and Computer Engineering Department at Rutgers University. He received the BS (2002) from Georgia Institute of Technology and the MS (2004) and PhD (2008) all in electrical engineering from Stanford University. During his time at Stanford, he worked on the development of electronic microfluidic platforms for low-cost genomic and proteomic biomarker detection, and later worked as a Senior Research Engineer at the Stanford Genome Technology Center. In Fall 2014, he joined the Electrical and Computer Engineering Department, Rutgers University as an Assistant Professor. His research interests include developing portable and wearable technologies for continuous health monitoring and understanding the effects of the environment on health. In 2017, he was recipient of the Translational Medicine and Therapeutics Award by the American Society for Clinical Pharmacology and Therapeutics for his group's work in point of care diagnostic tools for assessing patient response to cancer therapies. He has received various awards as a Principal Investigator from the National Science Foundation, National Institutes of Health, DARPA, and the PhRMA foundation to support his research. He was awarded the National Science Foundation CAREER Award for young faculty in 2019 and the DARPA Young Faculty Award in 2020. In 2018, he co-founded RizLab Health, a startup company dedicated to enabling point-of-care hematology analysis. ~BME Faculty Host: Dr. Hugh Lee ~ Seminar for Neurotrauma and Diseases Join the Center for Paralysis Research as we host the Spring 2022 installment of the Seminar for Neurotrauma and Diseases, sponsored by Plexon Neurotechnology Systems! There will be six seminars this semester, on February 9, February 23, March 9, March 23, April 6, and April 20, all from 4:00 PM-5:00 PM EST on Zoom. This neurotrauma-focused seminar will host speakers from Purdue, Harvard, and Carnegie Mellon universities. Distinguished experts in their respective fields will present on a variety of neurobiology- and SCI/TBI-related topics, sharing their unique focuses and cutting-edge research. Individual announcements, including abstracts and other presentation information, will be coming shortly, so keep an eye out for those! View the seminar live at https://bit.ly/3tDZOfm. Some seminars will be recorded, so if you can’t make the live event, make sure to check out our website<https://vet.purdue.edu/cpr/Seminar%20for%20Neurotrauma.php> for the latest updates. Contact us with any questions at cpr(a)purdue.edu<mailto:cpr@purdue.edu>! BME Bytes Wednesday, February 9, 1:30 pm, Location MJIS 1083. Presenter: Sarah Libring. “Using Fibronectin-Based Drug Screening Platforms for Precision Medicine of Metastatic Breast Cancer Patients.” Open to all undergraduate and graduate researchers. Lunch will be provided. Breast cancer is the most commonly diagnosed cancer in women. Current practice involves staining a biopsy of the primary tumor for hormone receptors (ER, PR, and HER2) in order to segment patients into more homogenous treatment groups. However, these clinical subtypes are often not representative of how the cancer cells will respond to treatment once the disease has metastasized. We have developed a 3D culture platform utilizing fibrillar fibronectin that facilitates breast cancer cell expansion and maintains cell behavior ex vivo. Using cells isolated from pleural effusions in metastatic breast cancer patients, we are using this platform to compile ex vivo drug sensitivity against 11 common chemotherapeutics with the patientsâ€™ medical history and clinical treatment response. We are also utilizing the fibrillar fibronectin platform to explore dormancy of breast cancer cells once disseminated to the lungs. We hope to translate these results to a Phase II Clinical Trial at the Netherlands Cancer Institute using the scaffolds as a predictive drug screening platform. About BME Bytes: BME Bytes is designed to help introduce undergraduate Purdue students to the breakthrough research happening at the Weldon School as well as help graduate students develop their professional portfolio by giving invited talks. Raising A Resilient Scientist Workshop Series (Message from Sharon Milgram, Director, NIH Office of Intramural Training & Education): Over the last year I have interacted with many trainees across the U.S. as part of the NIH Becoming a Resilient Scientist series<https://www.training.nih.gov/nih_becoming_a_resilient_scientist_series>. After carefully considering input from students, postdocs, faculty and program administrators who participated in the program, I have decided to offer a series, RAISING A RESILIENT SCIENTIST<https://www.training.nih.gov/workshops_and_trainings_for_extramural_princip…>, for faculty and administrators who mentor students and postdoctoral fellows in the biomedical, behavioral, and social sciences. The goal of the Raising a Resilient Scientist series is to promote the mental health and well-being of the academic research community by supporting faculty and administrators to develop self-management, relationship-management, and mentoring skills. A variety of topics will be covered with a specific focus on communication and shared problem-solving to help trainees deal with the inevitable setbacks experienced in high knowledge environments. There will be five units in the series; each unit will consist of a 75-minute lecture, which can be watched in real-time or asynchronously, followed by a 1-hour facilitated discussion with peers. There will be two opportunities for participation in the small groups following each webinar. There is no charge for participation, but advanced registration is required. For more information, and to register, please visit our webpage<https://www.training.nih.gov/workshops_and_trainings_for_extramural_princip…>. I do not anticipate offering this series again in the future; participation in the entire series is recommended but is not required. Please do not hesitate to email me if you have any questions. IBSC BME Preliminary Exam Announcement for Edmond Rogers (R. Shi, advisor) Research Title: Elucidating Pathological Correlations between Traumatic Brain Injury and Alzheimer’s Disease Committee Members: Major professor: Riyi Shi Members: Joseph Rispoli, Fang Huang, GuangJun Zhang Date/Time: Thursday February 10th from 10am-12pm Location: MJIS 2001 Abstract: One of the greatest consequences of Traumatic Brain Injuries (TBI) are the resulting long-term effects, especially in milder cases where the damage is initially subclinical and thus lacking acutely observable manifestations that can compound significantly over time. Among these chronic issues, Alzheimer’s Disease (AD) is one of the most serious. While a link between TBI and AD has been established, it has not yet been mechanistically elucidated. Multiple hypotheses have been postulated based on various animal/clinical models, which have contributed a great deal to our knowledge base and implicated several key pathways. While extremely valuable, these in vivo procedures and analyses are physiologically and ethically complex: there is currently no model capable of visualizing TBI-induced sub-cellular damage in the seconds immediately following injury, and the subsequent associated long-term changes. It is clear that additional investigative tools are needed, and while in vitro methodologies generally offer the type of resolution required, no such model replicates this phenomenon. Therefore, we introduce the “TBI-on-a-chip” concussive model prototype, with a series of concomitant targeted-experiments to address this currently unmet need. We hypothesize that both the primary, mechanical injury and long-term associated damages (secondary injury) can be successfully recapitulated in vitro, and utilized for mechanistic studies into trauma induced neurodegeneration. Further, we hypothesize that aggregation (β-amyloid) can be initiated by force–solo and demonstrated in our proposed system, further linking TBI with AD. Our ultimate goal is to facilitate translational discoveries by exploring the mechanisms underpinning TBI, acute and chronic, and the link to neurodegeneration. BME PhD Defense Announcement for John G. Damrath IV (J. Wallace, advisor) Title of thesis research: Multiscale Characterization of Skeletal Properties in Diabetes and Chronic Kidney Disease Date/time/place: February 11th, 2022, 11AM-12PM, Joseph E. Walther Hall (R3), room C203 (IUPUI) and via Zoom* * JD Damrath is inviting you to a scheduled Zoom@IU meeting. Topic: JD Damrath Dissertation Defense Time: Feb 11, 2022 11:00 AM Eastern Time (US and Canada) Join from computer or mobile: https://iu.zoom.us/j/81801089129 Meeting ID: 818 0108 9129 Committee members: Joseph M. Wallace, PhD - Major professor Sharon M. Moe, MD Matthew R. Allen, PhD Sherry Voytik-Harbin, PhD Sungsoo Na, PhD Abstract: Chronic kidney disease (CKD) affects 15% of Americans and dramatically increases their risk of skeletal fractures and fracture-related mortality. The progression of CKD is marked by abnormal biochemistries including disrupted mineral homeostasis and elevated parathyroid hormone (PTH). High PTH is linked to the bone alterations seen in CKD including cortical porosity and altered turnover. To mitigate the effects of sustained elevations in PTH, dialysis patients are commonly given calcimimetics which act by sensitizing the calcium-sensing receptor on parathyroid chief cells, lowering PTH synthesis and secretion. While calcimimetics are suggested to reduce fracture risk in dialysis patients, little is known about how these drugs impact bone tissue properties or whether they can be implemented in early CKD to prevent CKD-induced bone deterioration. Therefore, understanding how calcimimetics alter bone quality may reveal new strategies to prevent fractures in patients with CKD. While CKD represents a major global health crisis, nearly half of all CKD patients also have diabetes. Diabetes disrupts numerous physiologic systems and independently increases fracture risk by lowering bone mass and quality. Therefore, we have two major objectives in this work. Firstly, we developed a method for analyzing bone composition and material properties in a spatially resolved manner and found that calcimimetics increase mineral crystallinity and stiffness in newly formed periosteal bone while increasing relative mineralization, stiffness, and hardness in perilacunar bone. Further, we found that these properties depended on distance from the osteocyte lacunar wall. Secondly, we developed a novel combined murine model of type 1 diabetes and CKD which revealed a unique combination of detriments in structural and tissue-level bone microarchitecture, mechanical properties, and fracture toughness. Taken together, this work represents a thorough investigation of how diabetes and CKD alter bone quality on multiple scales and how calcimimetics improve bone quality in localized regions in early CKD. BME PhD Defense Announcement for Sarah Lipp (S. Calve, advisor) Title: Defining tissue level architecture changes in extracellular matrix during murine kidney and forelimb myotendinous junction development Date: February 14, 2022 Time: 11:00 AM ET Zoom link: https://iu.zoom.us/j/88099753662?pwd=emp6YkpUVzVPLzZlV3BoRTdzVnFEQT09 Meeting ID: 880 9975 3662; Password: 715208 Advisory Committee: Sarah Calve, PhD, Chair David Hains, MD Tamara Kinzer-Ursem, PhD Andrew Schwaderer, MD Luis Solorio, PhD Abstract: Congenital diseases of the kidney are the leading cause of chronic kidney disease in pediatric patients. Tissue engineering models used to investigate these diseases are limited by an immature phenotype. Models cultured in an extracellular matrix (ECM), a network of proteins and glycosaminoglycans surrounding cells and providing structural support that mimic the matrix found in development will be likely more mature. However, developing kidney ECM composition and structural dynamics are unknown. To address this gap, we studied ECM composition using mass spectrometry and organization by visualizing the ECM in 3D. In this work, we used mass spectrometry to resolve ECM basement membrane and interstitial matrix dynamics between embryonic, perinatal, and adult kidneys. Surprisingly, we observed a transient upregulation of interstitial matrix structures that corresponded to dynamic 3D structures in the cortex (vertical fibers) and at the corticomedullary junction (medullary ray sheath fibers). Notably, in a model of abnormal Foxd1+ stromal cells, the vertical fibers were disorganized, and medullary ray sheath fibers were no longer associated with blood vessels, suggesting the dynamic 3D structures depended on stromal cell modulation. One of the effects of abnormal kidney development is decreased amniotic fluid, which limits embryonic movement and subsequent limb development. In additional studies, we looked at the implications of the lost motility in the muscle dysgenesis (mdg) mouse on the development of the myotendinous junction (MTJ). The MTJ links contractile muscle with tendon. We found the ECM protein COL22A1 was specific to the developing MTJ as early as embryonic day (E)13.5. The development of the MTJ from a linear structure to a cap-like structure with invaginations in adolescent mice depended on muscle contraction. Furthermore, we used a model to decouple the muscle-tendon-bone complex at an ectopic lateral triceps insertion (Prrx1Cretg/+; Tbx3fl/fl). We observed disorganized tendon and MTJ markers at the termination of the ectopic lateral triceps muscle but negligible cartilage markers. Together, this indicated MTJ maturation depended on motility but not on the enthesis. The information gleaned from our studies on how stromal cells affect dynamic 3D interstitial ECM structures and composition change during kidney development can be used as a template for 3D kidney culture systems. Combined with forelimb MTJ development, our results indicate the importance of the interstitial matrix in tissue morphogenesis. Nomination Deadline for Excellence in PhD Graduate Student Research – Feb. 15, 5:00 p.m. We are seeking nominations to recognize excellence in PhD graduate student research. Before choosing to nominate one of your past or present BME or IBSC PhD students, please see the specific eligibility requirements and selection criteria that follow: Eligibility: · PhD students in good academic standing who have passed the preliminary exam; · Have graduated or are expected to graduate between June 1, 2021 and December 31, 2022; · Have published at least one peer-reviewed journal article and/or made at least one oral or poster presentation at a professional conference. For non-publicly published articles, certifications from appropriate authorities are needed. Priority should be given to papers where the student is lead author. Selection Criteria examples: Peer-reviewed publications in journals or conference proceedings; Awards for research, including best paper and outstanding presentations; Recognized or potential contribution of the research to the field; Recognized or potential contribution of the research to Society; Leadership within a research group or community (including mentoring of graduate and undergraduate students in their research); Academic achievement; Participation in professional societies. Nomination Deadline: The following materials are due to smmay(a)purdue.edu<mailto:smmay@purdue.edu> no later than February 15, 2022 at 5:00pm EST: · Letter from the student’s major professor addressing the selection criteria; · Copy of one paper accepted or published in a peer-reviewed journal or conference proceeding; · Copy of the student’s Purdue transcript. Biomedical Engineering will name one recipient for this award. The person that is selected will receive $2,000, a certificate, and recognition in a video by the College of Engineering. Any questions, let us know at smmay(a)purdue.edu<mailto:smmay@purdue.edu>. College of Engineering Outstanding Service Scholarship – nominations due February 15. The College of Engineering awards an Outstanding Service Scholarship of $2,000 to a graduate student in each school who has provided outstanding service to the graduate student community, the School, the College, and/or the University. Awardees will also receive a certificate as well as recognition in a video produced specifically for this achievement. Nominees should meet the following criteria: 1. Be pursuing a graduate degree (M.S. or Ph.D.) in our school. 2. Be in good academic standing with a minimum GPA of 3.0, with a higher GPA preferred. 3. Have completed at least one full calendar year in your graduate program at the time of the nomination. 4. Have contributed over time to the quality, reputation, or success of the graduate student community, School, College, and/or University. If you meet the above criteria and wish to submit a nomination, please provide the following documents as one single PDF to tsiemers(a)purdue.edu<mailto:tsiemers@purdue.edu> no later than 5:00PM on February 15, 2021 (NO exceptions): · Student’s self-written nomination letter describing evidence of #4 above (1-2 pages), plus a chronological list of your service activities; · Student’s current c.v.; · Student’s current Purdue transcript (unofficial will suffice) If you have any questions, contact Tammy Siemers (tsiemers(a)purdue.edu) BME PhD Defense Announcement for Hannah Cebull (C. Goergen, advisor) Everyone is invited to attend the public presentation beginning at 3:00PM ET. Title: Noninvasive biomechanical characterization of the aorta Date: February 21, 2022 Time: 3:00 PM ET Location: MJIS 2001 and Zoom – link below* Advisory Committee: Craig Goergen, Chair; Luis Solorio; Vitaliy Rayz; Ntobeko Ntusi Abstract: The aorta has many complex features including valve and vessel wall geometry, blood flow, and wall composition. Diseases such as aortic aneurysms and aortic valve lesions affect vessel function and may even lead to rupture, which can be fatal. However, current clinical diagnoses of aortopathies mainly rely on simple parameters such as diameter and growth rate. To better understand aortopathies and ultimately provide better patient diagnoses and treatments, it is important to investigate disease progression as well as the effect of vessel wall composition changes and hemodynamic forces on aortic biomechanics, such as strain and wall shear stress distribution. Preclinical research using small animals allows for disease progression to be studied while controlling outside factors. The next important step is to apply the methods used in the preclinical studies to human patient data. Both preclinical and clinical studies often focus on noninvasive, patient-specific methods for further characterizing the biomechanics of the aorta using advanced techniques such as 4D flow magnetic resonance imaging, 4D ultrasound, computational fluid dynamics (CFD), and fluid structure interaction (FSI) modeling. Yet the challenge of bridging these research techniques to a clinical setting remains. Factors such as financial costs, acquisition time, and ease of analysis must be considered. Therefore, the following document highlights two specific aims to extend our knowledge about the effects of aneurysms and aortic valve lesions. We will 1) characterize the regional effects of murine abdominal aortic aneurysms on strain over time, and 2) use CFD and FSI to simulate the hemodynamic effects on the thoracic aorta using both murine and human patient imaging data. Conducting research using clinically translatable methods of biomechanical characterization that consider the complexity of the aorta on a patient-specific basis will contribute to our understanding and lead to better patient outcomes. *Join Zoom Meeting https://purdue-edu.zoom.us/j/95658148163?pwd=djlCN1BaN1MyZzdLeTdNS0hHMDZMUT… Meeting ID: 956 5814 8163 Passcode: 539840 One tap mobile +13126266799,,95658148163#,,,,*539840# US (Chicago) +16465588656,,95658148163#,,,,*539840# US (New York) Find your local number: https://purdue-edu.zoom.us/u/adoKmAYkr3 Preclinical Innovation of Biomedical Translational Research: Indiana Clinical and Translational Science (CTSI) Virtual Retreat Please join us for the Indiana Clinical and Translational Science (CTSI) Virtual Retreat hosted by Purdue University on Tuesday, February 22, 2022 from 10AM - 3:30PM Eastern. REGISTER HERE<https://purdue.ca1.qualtrics.com/jfe/form/SV_9ssqC4oEet1aIIu> A keynote address will be given by Dr. Christopher Austin, CEO Partner of Flagship Pioneering and previous founding Director of the National Center for Advancing Translational Sciences (NCATS). The agenda includes: * Introduction from Indiana CTSI * Keynote speaker: Dr. Christopher Austin * Virtual Poster Session * Discussion Panels, including: * Novel technologies and capabilities at the CTSI institutions * Imaging techniques supporting many preclinical studies * Innovative preclinical animal models * Best practices for industry-academia collaboration in preclinical studies Partners of Indiana CTSI<https://indianactsi.org/> are Purdue University, Indiana University and the University of Notre Dame. CALL FOR POSTERS: https://engineering.purdue.edu/BME/AboutUs/News/2022/call-for-posters-india… Fourth Annual Conference for Associate Professors set for Feb. 23-24 The Susan Bulkeley Butler Center for Leadership Excellence in collaboration with the Office of the Provost will hold the Fourth Annual Conference for Associate Professors on Feb. 23-24 in Purdue Memorial Union. The conference is titled "Charting Your Path to Promotion." The conference will include a keynote address and two panel sessions. Over the course of the conference, attendees will have opportunities to network, share information and learn from others in ways that will enable associate professors, particularly women associate, to accelerate their progression to full professor. The panel sessions comprise speakers from within and outside Purdue. Although this conference targets associate professors, the strategies and insights offered by the keynote speaker and the panelists will be useful for all faculty members. Conference details include: o Keynote address: Elizabeth Field Hendry, provost and senior vice president for academic affairs, Queens College, CUNY. o Panel session 1: "Managing Time: Service, Teaching, Mentoring, and Research." o Panel session 2: “Promotion to Full Professor.” The conference is free for Purdue faculty, who must email butlercenter(a)purdue.edu<mailto:butlercenter@purdue.edu> for the code before registering. Faculty from outside Purdue will pay a registration fee. Registration will open in about two weeks. More information, including the conference schedule, keynote and panel sessions, is available on the conference webpage<https://www.purdue.edu/butler/conferences-for-faculty/conference-associate-…>. Please plan on joining The Graduate School’s Office of Interdisciplinary Graduate Programs (OIGP)<https://www.purdue.edu/gradschool/oigp/index.html> for our annual Spring Reception<https://www.purdue.edu/gradschool/oigp/events/spring-reception/index.html> in celebration of interdisciplinary graduate student research on Wednesday, May 4, 2022 from 10:00 AM to 12:00 PM in the Purdue Memorial Union North and South Ballrooms. Please consider submitting a presentation and applying for the Most Outstanding Interdisciplinary Project Award (MOIPA—winner receives $1000). Poster and Award Submission Deadline: Monday, February 28, 2022. Details can be found at the links below: Poster Submission Application and Details<https://www.purdue.edu/gradschool/oigp/events/spring-reception/submission.h…> Award Application and Details<https://www.purdue.edu/gradschool/oigp/events/spring-reception/award-applic…> Attachments *2022FulbrightWeek *2022 CTSI Winter Retreat Flyer -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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Update: Travel Expense Report Process
by Overly, Benjamin E 04 Feb '22

04 Feb '22

Good Morning, As an update to my original email below, please see today's related announcement in PurdueToday which slightly revises this process: https://www.purdue.edu/newsroom/purduetoday/releases/2022/Q1/new-online-sub…. "A new online submission form is now available to assist those who travel on official University-related business with the travel expense reporting process. Last year, Purdue Travel announced that travel expense reports would be centralized through its department. The transition from having travelers submit their own expense reports to having the Purdue Travel department compile the travel expense report on a traveler's behalf was completed in December. At that time, travelers or their delegates were given two methods to submit expenses for reimbursement upon returning from travel: * Add business expense receipts to the receipt store in the Concur mobile app. If travel was booked through Concur, Purdue Travel will reach out to the traveler or delegate to initiate the expense report process. * Attach business expense receipts in an email to purduetravel(a)purdue.edu<mailto:purduetravel@purdue.edu>. Travelers or their delegates must initiate this process on their own. Now, the online form will assist with the expense reporting process and the following changes will be made to the two submission methods: * Add business expense receipts to the receipt store in the Concur mobile app. If travel was booked through Concur, Purdue Travel will reach out to the traveler or delegate with the form to obtain additional information to complete the expense report. * *Instead of emailing purduetravel(a)purdue.edu<mailto:purduetravel@purdue.edu> for the second method, travelers or their delegates must submit receipts and expenses that were not booked through Concur or Anthony Travel through the online form<https://purdue.ca1.qualtrics.com/jfe/form/SV_cIym81HgtQRniyW>.* If receipts have already been submitted to purduetravel(a)purdue.edu<mailto:purduetravel@purdue.edu>, do not resubmit using the form as it will create duplicate records. The online form can also be found on the Purdue Travel website.<https://www.purdue.edu/procurement/travel/> Questions may be directed to Purdue Travel at 765-496-7354 or purduetravel(a)purdue.edu<mailto:purduetravel@purdue.edu>." Best regards, Benjamin Overly Business Manager Biomedical Engineering & LORRE Purdue University [cid:image001.png@01D819A2.90BE8130] From: Bmestaff-list <bmestaff-list-bounces(a)ecn.purdue.edu> On Behalf Of Overly, Benjamin E Sent: Thursday, January 27, 2022 3:09 PM To: bmestaff-list(a)ecn.purdue.edu; Bmewlfaculty-list(a)ecn.purdue.edu; bmepostdocs-list(a)ecn.purdue.edu; bmegradstudents-list(a)ecn.purdue.edu Subject: [Bmestaff-list] Travel Expense Report Process Change Importance: High Good Afternoon, Going forward, Purdue Travel has been restructured in order to assist with the Concur expense report process for employees who travel. Please see the below update on the new process and contact information for questions: Purdue Travel will provide all employees with a central, convenient way to submit travel receipts and business mileage, and then compile the travel expense report on the traveler's behalf. With this change, there is now a team dedicated to the creation of expense reports. Based on a completed pilot program, the centralization of travel expense reports is expected to significantly reduce the time to create an expense report and reimburse the traveler to just four to seven days. By transitioning this work to dedicated Purdue Travel staff, employees will have more time to focus on their core responsibilities. All employees or their delegates will need to submit expenses for reimbursement using one of the following methods upon returning from business travel: * Add business expense receipts to the receipt store in the Concur mobile app. If travel was booked through Concur or Anthony Travel, Purdue Travel will reach out to the traveler/delegate to initiate the expense report process. * Attach business expense receipts in an email to purduetravel(a)purdue.edu<mailto:purduetravel@purdue.edu>. Travelers or their delegates must initiate this process on their own by emailing the receipts. A list of required information and documentation<https://www.purdue.edu/procurement/travel/expenses/index.php> is available on the Travel website under the "Expense Reimbursement" header. For business mileage reimbursement to Purdue employees, either of the above processes may be used. The traveler will need to provide a copy of their mileage log or screenshots showing the distance of business mileage traveled (e.g., using Google Maps). The traveler also must provide the reason for travel in the comment box in Concur or in the email to purduetravel(a)purdue.edu<mailto:purduetravel@purdue.edu>. The Purdue Travel website has been updated to reflect the changes to travel expense reports<https://www.purdue.edu/procurement/travel/expenses/index.php>. Additional information and resources will be added as they become available. Questions may be directed to Purdue Travel at 765-494-7354 or purduetravel(a)purdue.edu<mailto:purduetravel@purdue.edu>. Thank you! Benjamin Overly Business Manager Biomedical Engineering & LORRE Purdue University [cid:image001.png@01D8136F.B90AF3F0]

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[Bmeroundtable-list] Prospective BME Faculty Seminar - Nancy Xu - Monday, February 7
by Gelfand, Johanna K 02 Feb '22

02 Feb '22

[cid:6052bfbb-8a89-46dc-a30b-7f09c018d537] Weldon School of Biomedical Engineering Prospective Faculty Seminar Monday, February 7, 2022 9:30-10:20am MJIS 1083 or Via Zoom: https://purdue-edu.zoom.us/j/95097354421?pwd=VHVHZGRLb21TVnNlczhEY2dKTjZKUT… New NanoBiotechnology for Sensing and Imaging of Single Live Cells: >From Fundamental Discoveries to Biomedical Innovations [cid:1422b007-cc53-4032-b205-7d5b17542232] X. Nancy Xu, PhD Professor in Biomedical Engineering, Biomedical Sciences, Biochemistry, and Chemistry Old Dominion University Abstract: Single cells are building blocks of all living organisms. Understanding of functions of individual live cells and their communications is essential to rationally design and engineer effective diagnosis and therapies. New tools for detecting and targeting specific individual cells would revolutionize disease diagnosis and treatments. Single live cells also offer unique inspiration for rational design and engineer biocompatible smart materials and devices for bioengineering innovation (e.g., self-powered, self-repaired, self-assembled, self-replicated “live” robots). To achieve these transformative potentials, it is crucial to depict how individual live cells function and communicate to enable specific functions in cell culture, tissues, live animals, and ultimately in human in real time at single-cell and single-molecule resolutions. Interactions of couples of molecules in single live cells can induce a cascade of vital cellular responses and alter cellular and tissue functions. Current tools are unable to real-time study molecular machineries of single live cells with adequate quantitation, spatial and temporal resolutions and over a desired long period of time. We have pioneered the development of a set of powerful new technologies, including photostable single plasmonic nanoparticle imaging probes, single molecule nanoparticle optical biosensors (SMNOBS), and far-field photostable optical nanoscopy (PHOTON). We have demonstrated that these new tools can overcome the drawbacks of fluorescence-based imaging platforms for dynamic, single molecule and multiplexing imaging of single live cells with superior temporal and spatial resolutions and over a long period of time (hours, days, weeks). We have used these new tools to real-time study: (i) molecular cascades of signaling transduction pathways of single live cells; (ii) molecular mechanisms of multidrug resistance of single live cells; (iii) efficacies of single drug nanocarriers; (iv) native environments of developing embryos and differentiation of embryonic stem cells into cardiomyocytes and neurons; and (v) rare subsets of single cancer stem cells (CSCs) in clinical tissues for exploring new paradigm of early cancer detection and targeted therapy. We are currently developing new nanobiophotonic sensing and imaging platforms for real-time large-scale recording and modulation of neuron-neuron communicates, aiming to understand how brain develops and functions and how to effectively detect, diagnose and treat brain diseases. In this seminar, I will describe these new nanobiotechnologies and their innovative biomedical engineering applications. The work was supported by NIH and NSF. [cid:bcb480b0-b69e-45fd-8b1b-7ec9c794d726] Bio: Dr. X. Nancy Xu is the AAAS Fellow and Professor of Biomedical Engineering, Biomedical Sciences, Biochemistry, and Chemistry at Old Dominion University (ODU). During her tenure at ODU, Dr. Xu has built a state-of-the-art interdisciplinary research laboratory, and successfully developed a nationally and internationally recognized and well-funded interdisciplinary research program at the interface of chemistry, biology, engineering, and medicine. Dr. Xu has successfully directed NSF and NIH funded interdisciplinary research programs and she has demonstrated a track-record of accomplishments in successfully competing for highly prestigious federal research grants, including NSF NIRT, NSF BRAIN Initiative, NIH R01, and DoD MURI awards. Dr. Xu has pioneered the development of a set of powerful new sensing and imaging technologies for biomedical applications. She is especially well recognized for her pioneering work in single nanoparticle optics, single nanoparticle plasmonic spectroscopy, single molecule sensing, and single live cell imaging. Dr. Xu holds a world-wide patent on DNA Biosensors and has consistently published her work in high-impact peer-reviewed journals. Dr. Xu has led and developed several new graduate and undergraduate courses and she has taught 26 different courses on various topics including biosensing, imaging, biomedical sciences, biomedical engineering and nanobiotechnology. Dr. Xu has served as an expert reviewer and panelist for 15 national and international funding agencies, 62 NIH grant review panels and 26 NSF grant review panels. Dr. Xu has led and served as a track director/coordinator for an interdisciplinary joint PhD program in Biomedical Sciences between ODU and Eastern Virginia Medical School. and as the member of advisory board of Frank Reidy Research Center for Bioelectrics. Dr. Xu has received several prestigious national awards (e.g., Nano 50 Innovator Award, Nano 50 Technology Award, NSF BRAIN Initiative EAGER Award, Finalist of NIH Follow That Cell Challenge, ACS Roland F. Hirsch Award, and AAAS Mentor Award) and university awards (e.g., Distinguished Research Award, Faculty Research Achievement Award, University Presidential Diversity Champion Award, student-nominated Shining Star Recognition and Most Inspired Faculty Member Designation). Dr. Xu received her B.S. from Xiamen University and her Ph.D. from the University of Mississippi. She was a postdoctoral fellow at the University of Texas at Austin and Ames Lab-Iowa State University. Her profile is at www.odu.edu/~xhxu<http://www.odu.edu/~xhxu>. ~BME Host: Hugh Lee~ -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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[Bmeroundtable-list] BME Prospective Faculty Seminar - Connie Wu - Wed., Feb. 2
by Gelfand, Johanna K 01 Feb '22

01 Feb '22

[cid:image001.jpg@01D81770.7AA2B850] Weldon School of Biomedical Engineering Prospective Faculty Seminar Wednesday, February 2, 2022 9:30-10:20am MJIS 1001 or Via Zoom: https://purdue-edu.zoom.us/j/95150439811?pwd=a3hOK0o0bmpkS3poTVBCbVhDNU9FZz… Tackling Disease-associated Biomolecules: >From RNA Therapeutics to Single-molecule Detection [cid:image002.jpg@01D81770.7AA2B850] Connie Wu, Ph.D. NIH F32 Ruth L. Kirschstein Postdoctoral Research Fellow Department of Pathology, Harvard Medical School and Brigham and Women's Hospital Abstract: The functionality versatility of polymeric and nucleic acid materials provides diverse engineering opportunities for the detection and therapeutic targeting of disease-associated biomolecules. My work has encompassed nanoscale and microscale technologies to address challenges in cancer therapeutics and diagnostics, from targeting the expression of dysregulated genes to probing rare protein biomarkers. I will first describe the design of a highly potent small interfering RNA nanoparticle delivery system that leverages approaches in nucleic acid engineering and polymer chemistry. Towards overcoming analytical barriers in clinical diagnostics, I will then describe the development of ultrasensitive single-molecule detection technologies to measure low abundance proteins. By utilizing powerful molecular amplification methods and simple signal readouts, these digital enzyme-linked immunosorbent assay (ELISA) platforms enable the detection of low attomolar (10-18 M) protein concentrations, with over four orders-of-magnitude improvements in sensitivity over conventional protein detection methods. Importantly, these methods democratize ultrasensitive protein detection, enabling high-throughput, high-multiplex digital measurements to be carried out with common laboratory instrumentation. Finally, I will highlight the application of digital ELISA technology towards the development of an ultrasensitive blood test for a retrotransposon-encoded protein as a highly specific multi-cancer biomarker. Overall, the development of these technologies can pave the way towards the future integration of materials and biomolecular engineering approaches with ultrasensitive bioanalytical tools for accelerating biomarker signature discovery and precision medicine. Bio: Connie is an NIH F32 Ruth L. Kirschstein postdoctoral research fellow in Dr. David Walt's lab at Brigham and Women's Hospital and the Wyss Institute for Biologically Inspired Engineering at Harvard University. She obtained her B.S. in chemical engineering from Yale University, where she worked with Dr. Paul Van Tassel in designing porous layer-by-layer polymer films for tissue engineering applications and received a Barry M. Goldwater Scholarship. Connie pursued her Ph.D. in chemical engineering at MIT, working in Dr. Paula Hammond's lab on polymer-based RNA interference delivery systems for cancer therapeutics. She was the recipient of multiple fellowships during her Ph.D. training, including an NSF Graduate Research Fellowship, Ludwig Center for Molecular Oncology Graduate Fellowship, and MIT Presidential Fellowship. In her current postdoctoral work, Connie has developed ultrasensitive single-molecule detection platforms for biomarker discovery and diagnostic applications. ~BME Faculty Host: Dr. Vitaliy Rayz ~ -- Bmeroundtable-list mailing list Bmeroundtable-list(a)ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list

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