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Graduate Seminar Series - Dr. N.-H. Linda Wang
by Ewing, Virginia G 07 Apr '14

07 Apr '14

Purdue University School of Chemical Engineering GRADUATE SEMINAR SERIES Dr. N.-H. Linda Wang School of Chemical Engineering Purdue University "Fundamental Advances and Applications of Chromatography" April 8, 2014 9:00-10:00 a.m. FRNY G140 Reception immediately following the talk in G140. Abstract. Chromatography processes are highly versatile and selective separation techniques. They have been used for the analysis and purification of many chemicals and biochemicals in foods, fuels, wastes, and pharmaceuticals. In this presentation, I will explain the fundamental principles of chromatography and a continuous process called simulated moving bed chromatography (SMB) and several new technologies developed in my group. The talk will focus on (1) a general method of designing affinity chromatography processes and applications for the production of a medical isotope, and (2) the standing-wave design method (SWD) and applications in designing SMBs for insulin purification, for the recovery of six sugars from biomass hydrolysates, and for the recovery of valuable chemicals from electronic wastes. Bio: Dr. Nien-Hwa Linda Wang has been a professor of Chemical Engineering at Purdue University since 1980. She received her PhD in Chemical Engineering from the University of Minnesota in 1978. She is internationally known for her research contributions in mass transfer, adsorption, multi-component chromatography, and simulated moving beds. The results were described in more than 120 journal articles, six book chapters, two patents, and two current patent applications. She has given more than 100 invited lectures and more than 200 presentations in national and international meetings. She has developed several new chromatography and simulated moving bed technologies that are applicable to the design of a wide range of adsorption and chromatography processes. She was a Director (2001-2004) and the Chair (2013) of the Separation Division of the American Institute of Chemical Engineers, and a Director of the International Adsorption Society (2001-2007). She is a Fellow of the American Institute of Medical and Biological Engineering and the American Institute of Chemical Engineers. She has served as a consultant to NIH, NSF, Oak Ridge National Laboratories, Argonne National Laboratories, and more than 20 chemical, food, and pharmaceutical companies.

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Doug Lauffenburger Seminar April 9 @ 9:30am MJIS 1001
by Ewing, Virginia G 07 Apr '14

07 Apr '14

BME Seminar Series Wednesday, April 9, 2014 9:30-10:20am MJIS 1001 Weldon School of Biomedical Engineering Purdue University Dynamical Feedback Circuits in Cell Biology: Integrative Network Analysis of Receptor/Ligand Signaling Pathways and Proteolytic Feedback Circuits Governing Invasive Cell Migration Douglas A. Lauffenburger<https://sharepoint.ecn.purdue.edu/coe/bme/gradseminar/_Layouts/listform.asp…>, Ph.D. Ford Professor and Head of Bioengineering Departments of Biological Engineering and Biology MIT Abstract: Biochemical signals induced by receptor tyrosine kinases (RTKs) governs mammalian cell behaviors involved in physiology and pathology. RTK signaling is, at the same time, regulated by processes influencing receptor/ligand binding; in recent years, activities of cell surface proteases such as ADAMs have become identified as a key locus for this regulation via shedding receptor and ligand ectodomains. These protease activities are, in turn, modulated by RTK signaling pathways. Thus, the traditional “upstream/downstream” perspective of receptor signaling to cell behavior is generally inadequate for understanding how pathological dysregulation transpires and may be treated by molecular interventions. In the context of malignant diseases including cancer and endometriosis, we have been pursuing a combined experimental/computational approach integrating multiple kinase signaling pathway activities, protease activities, and receptor/ligand shedding in order to determine regulatory network logic governing invasive cell migration. Applying our inferred network model to understanding effects of small molecule inhibitors for kinase pathways, we have identified an ADAM-based mechanism of drug resistance through reduced RTK shedding that can be overcome with appropriate inhibitor combinations. Most recently, we have probed clinical relevance of this mechanism to disease therapeutics with animal model and human patient studies. Bio: Prof. Doug Lauffenburger is the Ford Professor and Head of Biological Engineering, and Professor of Biology at MIT. His research program uses molecular and cellular bioengineering and quantitative biology techniques to study cellular signaling, receptor/ligand dynamics, cell migration, proliferation, differentiation and cell death applied to cancer and endometriosis. His lab has demonstrated that these approaches can be used to identify drug targets and molecular therapeutics to treat these diseases. Prof. Lauffenburger has co-authored more than 375 journal articles and book chapters, has won numerous honors and awards for his foundational work in systems biology and bioengineering, and is a member of both the National Academy of Engineering and the American Academy of Arts and Sciences. ~BME Faculty Hosts: Ann Rundell and Tamara Kinzer-Ursem~ *Sometime after 10:30AM on the day of seminar, go to the link http://boilercast.itap.purdue.edu:8080/ess/feed?id=847e407f-8a44-4b49-ba4b-… to view a recording of that day’s seminar. Works well with Mozilla Firefox, will not work with Google Chrome. Thank you, Tamara Kinzer-Ursem Assistant Professor Weldon School of Biomedical Engineering Purdue University http://engineering.purdue.edu/ursemlab

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Indiana Soybean Competition - 4 year record for ChE!
by Varma, Arvind 04 Apr '14

04 Apr '14

Dear Colleagues, I am delighted to inform that for the 4th year in a row, a team including one or more ChE students has won the $20,000 first prize in the Student Innovation Contest<http://www.indianasoybean.com/strategic-programs/new-use-innovation/43-stra…> sponsored by the Indiana Soybean Alliance. This year ChE graduate student Nicole Devlin and ChE senior Yanssen Tandy, along with ME senior Carmen Valverde-Paniagua, won the first prize for their S3D Innovations team which developed Filasoy, a next generation 3D printing material. Filasoy replaces petroleum-based plastic with a low-energy, low-temperature, renewable and recyclable filament. It retains similar properties found in a bioplastic with an added "green" twist - it allows printing without waste. For details, pl visit: http://www.purdue.edu/newsroom/releases/2014/Q1/purdue-students-show-how-to… With best wishes, Arvind Arvind Varma R. Games Slayter Distinguished Professor Jay and Cynthia Ihlenfeld Head of Chemical Engineering Purdue University

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Congratulations to Drs Liu, Morgan, Won and Wu!
by Varma, Arvind 04 Apr '14

04 Apr '14

Dear Colleagues, I am absolutely delighted to inform that in their meeting this morning, the Board of Trustees approved the following promotions, effective this Fall semester: Julie Liu - Associate Professor, with tenure John Morgan - Professor You-Yeon Won - Professor Yue Wu - Associate Professor, with tenure These colleagues are doing brilliant research and influential teaching. Pl join me in congratulating them for their promotions. In all their cases, the best is yet to come and our School's future is bright! With best wishes, Arvind Arvind Varma R. Games Slayter Distinguished Professor Jay and Cynthia Ihlenfeld Head of Chemical Engineering Purdue University

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Dr. Joona Bang Bio/Abstract - April 10, 2014
by Waibel, Lucinda M 04 Apr '14

04 Apr '14

Purdue University School of Chemical Engineering Graduate seminar series Prof. Joona Bang Dept. of Chemical and Biological Engineering Korea University "Design of Cross-Linkable Block Copolymers for Various Nano-Fabrications" Thursday, April 10, 2014 9:00-10:20 a.m. FRNY G140 Reception at 8:30 a.m. in Henson Atrium Abstract. --- In designing polymeric materials for use in nanotechnology it rapidly becomes apparent that control over all aspects of polymer structure (molecular weight, polydispersity, number and position of functional groups, architecture, etc.) is required. Equally important to the rapid introduction and incorporation of these materials into devices is the development of robust and simple techniques for their synthesis. Living free radical procedures have been developed and employed in the preparation of various functionalized polymers. These systems address a wide range of manufacturing issues for the successful adoption of such functional polymers as a viable nanofabrication technique. In the presentation, living radical polymerization was employed to design the photo-crosslinkable block copolymers, and their uses for various nanofabrications such as buildup of 3-dimensional multilayered nanostructures and functional nanocomposites will be discussed. Bio. Joona Bang received his B.S. degree in Chemical Engineering from Seoul National University in 1999. He received his Ph.D. degree in Chemical Engineering from University of Minnesota in 2004 on block copolymer physics under a guidance of Prof. Tim Lodge. He worked as a postdoctoral fellow on polymer chemistry and polymer thin films in Prof. Hawker's group at the University of California, Santa Barbara. Since 2006, he has been at Korea University as an associate professor in Chemical and Biological Engineering. His research interests include self-assembly of block copolymer thin films, living free radical polymerization, organic/inorganic nanocomposites, and polymeric membranes for water purification. Best Regards, Cindy Waibel Secretary ~ Rm 1144 Forney Hall of Chemical Engineering Purdue University 480 Stadium Mall Drive West Lafayette, IN 47907-2100 765-494-4069 Fax: 765-494-0805 leiklebe(a)purdue.edu<mailto:leiklebe@purdue.edu> [http://web.ics.purdue.edu/~snpha/purdue_train3.gif]

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2014 ChE Excellence in Safety Award
by Nagy, Gabriela 03 Apr '14

03 Apr '14

Good afternoon, This is just a reminder that the due date to submit your nominations for the 2014 ChE Excellence in Safety Award is April 10, which is next week. Please use the attached nomination form and send your nominations to Gabriela Nagy (email nagyg(a)purdue.edu<mailto:nagyg@purdue.edu>) by April 10, 2014. Thank you for your commitment to safety! Sincerely, Gabriela On behalf of the ChE Safety Committee ________ Gabriela Nagy, PhD Industrial Education Director ChE Safety Committee Chair School of Chemical Engineering Room FRNY G051 Purdue University Tel: (765)-496-1710 E-mail: nagyg(a)purdue.edu<mailto:nagyg@purdue.edu> From: Che-staff-list [mailto:che-staff-list-bounces@ecn.purdue.edu] On Behalf Of Nagy, Gabriela Sent: Saturday, March 15, 2014 4:48 PM To: chme(a)ecn.purdue.edu; chmegrad(a)ecn.purdue.edu Subject: [Che-staff-list] Nominations accepted for the 2014 ChE Excellence in Safety Award Hello Everyone, The Chemical Engineering Safety Committee is happy to invite nominations for the 2014 ChE Excellence in Safety Award. Please find attached the nomination form, award description and details on eligibility and selection criteria. Nomination Process: Any ChE faculty member, staff, graduate or undergraduate student performing research can nominate any eligible ChE graduate student. A nominator can support only one candidate. Please submit your nominations to Gabriela Nagy at nagyg(a)purdue.edu<mailto:nagyg@purdue.edu>, by April 10, 2014. Nominations should not exceed 250 words and should include specific examples. Due Date for nominations: April 10, 2014, with the award to be presented at the May appreciation reception. Selection: The selection will be made by the ChE Excellence in Safety Award Committee, and communicated to all School employees and students. Thank you for your commitment to safety! Sincerely, Gabriela On behalf of the ChE Safety Committee ________ Gabriela Nagy, PhD Industrial Education Director ChE Safety Committee Chair School of Chemical EngineeringIRoom FRNY G051 Purdue University Tel: (765)-496-1710 E-mail: nagyg(a)purdue.edu<mailto:nagyg@purdue.edu>

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Graduate Seminar Series - Dr. N.-H. Linda Wang
by Ewing, Virginia G 03 Apr '14

03 Apr '14

Purdue University School of Chemical Engineering GRADUATE SEMINAR SERIES Dr. N.-H. Linda Wang School of Chemical Engineering Purdue University "Fundamental Advances and Applications of Chromatography" April 8, 2014 9:00-10:00 a.m. FRNY G140 Reception immediately following the talk in G140. Abstract. Chromatography processes are highly versatile and selective separation techniques. They have been used for the analysis and purification of many chemicals and biochemicals in foods, fuels, wastes, and pharmaceuticals. In this presentation, I will explain the fundamental principles of chromatography and a continuous process called simulated moving bed chromatography (SMB) and several new technologies developed in my group. The talk will focus on (1) a general method of designing affinity chromatography processes and applications for the production of a medical isotope, and (2) the standing-wave design method (SWD) and applications in designing SMBs for insulin purification, for the recovery of six sugars from biomass hydrolysates, and for the recovery of valuable chemicals from electronic wastes. Bio: Dr. Nien-Hwa Linda Wang has been a professor of Chemical Engineering at Purdue University since 1980. She received her PhD in Chemical Engineering from the University of Minnesota in 1978. She is internationally known for her research contributions in mass transfer, adsorption, multi-component chromatography, and simulated moving beds. The results were described in more than 120 journal articles, six book chapters, two patents, and two current patent applications. She has given more than 100 invited lectures and more than 200 presentations in national and international meetings. She has developed several new chromatography and simulated moving bed technologies that are applicable to the design of a wide range of adsorption and chromatography processes. She was a Director (2001-2004) and the Chair (2013) of the Separation Division of the American Institute of Chemical Engineers, and a Director of the International Adsorption Society (2001-2007). She is a Fellow of the American Institute of Medical and Biological Engineering and the American Institute of Chemical Engineers. She has served as a consultant to NIH, NSF, Oak Ridge National Laboratories, Argonne National Laboratories, and more than 20 chemical, food, and pharmaceutical companies.

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Graduate Seminar Series - Dr. Deborah E. Leckband
by Heide, Karen Kay 31 Mar '14

31 Mar '14

Purdue University School of Chemical Engineering GRADUATE SEMINAR SERIES Dr. Deborah E. Leckband Reid T Milner Professor of Chemical Sciences Department of Chemistry University of Illinois at Urbana "Thermally Responsive Polymers In Biotechnology: New Perspectives On An Old Problem" Tuesday, April 1, 2014 9:00-10:30 A.M. FRNY G140 Refreshments at 8:30 AM in Henson Atrium, FRNY Hall Abstract. The temperature-dependent solubility of poly(N-isopropyl acrylamide) is exploited to reversibly switch polymer interactions with proteins and cells at the lower critical solution temperature (LCAT) near 32°C. Two notable applications are cell sheet engineering and thermally programmed protein separations. Both applications hinge on achieving reversible bioadhesion to PNIPAM coatings, but a fundamental challenge has been the identification of polymer design parameters that impact reversible bioadsorption above and below the LCST. For decades, the assumption has been that thermally triggered polymer collapse and reswelling are essential for thermally reversible bioadhesion. I will present evidence that contradicts this view, but provides an alternative model consistent with current data. Surface force measurements, neutron reflectivity, and AFM imaging characterized the brush architecture as a function of the chain density, chain molecular weight, and temperature. The latter findings were in turn compared with temperature-dependent protein (and cell) adsorption and release. Qualitative comparisons of the experimental trends with theories for polymer brushes and their interactions with proteins in good and poor solvents suggests an alternative model for thermally-switchable bioadsorption, as well as design guidelines for tailoring the performance of PNIPAM coatings in these biological applications. Bio: Deborah Leckband pioneered the use of force measurements to quantify biomaterial surface properties at the molecular scale and their impact on material performance in biotechnology and the clinic. She investigated a range of materials, including water-soluble polymers, membranes, and immobilized proteins. Findings resulted in novel insights regarding how molecular scale surface forces impact many applications including drug delivery, biofouling, biosensing, and fundamental biological issues such as cell-cell cohesion. Her studies of biomaterials, in particular, often transformed long-held views on mechanisms underlying bioadhesion and how to control them.

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Fwd: Shiva Haghighi Memorial
by Varma, Arvind 27 Mar '14

27 Mar '14

Colleagues, I am sorry to transmit this sad news... Arvind Sent from my iPhone Begin forwarded message: From: Leah Jamieson <lhj(a)purdue.edu<mailto:lhj@purdue.edu>> Date: March 27, 2014 4:48:58 PM CDT To: Ahmed Hassanein <hassanein(a)purdue.edu<mailto:hassanein@purdue.edu>>, Anil Bajaj <anil.k.bajaj.1(a)purdue.edu<mailto:anil.k.bajaj.1@purdue.edu>>, "Bahr, David F" <dfbahr(a)purdue.edu<mailto:dfbahr@purdue.edu>>, Venkataramanan Balakrishnan <ragu(a)purdue.edu<mailto:ragu@purdue.edu>>, Elizabeth M Holloway <holloway(a)purdue.edu<mailto:holloway@purdue.edu>>, David Carmichael <carmicha(a)purdue.edu<mailto:carmicha@purdue.edu>>, "Melba M Crawford" <mcrawford(a)purdue.edu<mailto:mcrawford@purdue.edu>>, Dale Harris <harris(a)purdue.edu<mailto:harris@purdue.edu>>, "David Radcliffe" <dradcliffe(a)purdue.edu<mailto:dradcliffe@purdue.edu>>, Abhi Deshmukh <abhi(a)purdue.edu<mailto:abhi@purdue.edu>>, "Jason Matthew Dietz" <dietz(a)purdue.edu<mailto:dietz@purdue.edu>>, "Bernard A. Engel" <engelb(a)purdue.edu<mailto:engelb@purdue.edu>>, Audeen Fentiman <fentiman(a)purdue.edu<mailto:fentiman@purdue.edu>>, "Robert J. Frosch" <frosch(a)purdue.edu<mailto:frosch@purdue.edu>>, Rao S Govindaraju <govind(a)purdue.edu<mailto:govind@purdue.edu>>, Michael T Harris <mtharris(a)purdue.edu<mailto:mtharris@purdue.edu>>, Makarand Hastak <hastak(a)purdue.edu<mailto:hastak@purdue.edu>>, Klod Kokini <kokini(a)purdue.edu<mailto:kokini@purdue.edu>>, "Carolyn A. Percifield" <carolynp(a)purdue.edu<mailto:carolynp@purdue.edu>>, "Pinion, Tyson L" <tlpinion(a)prf.org<mailto:tlpinion@prf.org>>, David C Robledo <drobledo(a)purdue.edu<mailto:drobledo@purdue.edu>>, "Tom I-P. Shih" <tomshih(a)purdue.edu<mailto:tomshih@purdue.edu>>, John Sutherland <jwsuther(a)purdue.edu<mailto:jwsuther@purdue.edu>>, Arvind Varma <avarma(a)purdue.edu<mailto:avarma@purdue.edu>>, George Wodicka <wodicka(a)purdue.edu<mailto:wodicka@purdue.edu>>, William J Sondgerath <wsondgerath(a)purdue.edu<mailto:wsondgerath@purdue.edu>> Cc: Leah Jamieson <lhj(a)purdue.edu<mailto:lhj@purdue.edu>>, Noah Amy R. <ARNoah(a)prf.org<mailto:ARNoah@prf.org>> Subject: Fwd: Shiva Haghighi Memorial Colleagues - It is with great sadness that I share this news about the death of Kamyar Haghighi's daughter, Shiva. Many of us knew and loved Kamyar and also knew Shiva, both as his daughter and as a Purdue Engineering student. My heart goes out to Kamyar's wife/Shiva's mother, Atossa, and to Shiva's sister, Nina. The obituary is at http://hosting-5049.tributes.com/obituary/show/Shiva-Haghighi-101055007 A memorial scholarship fund at Purdue has been established in Shiva's memory. Gifts may be made either through the crowd-funding site https://shivahaghighi.crowdtilt.com or by check payable to the Purdue Foundation with a note that the gift be directed to the fund in honor of Shiva Haghighi. The checks can be sent to Amy Noah at the Dauch Alumni Center, 403 West Wood Street, West Lafayette, IN 47907-2007. Keith Hansen (BSBME 2012) was the student responder at the Engineering commencement ceremony in May 2012, a year after Kamyar's passing. Keith's commencement address was built around the inspiration that Kamyar had been for him. Please share the sad news. leah Begin forwarded message: From: Keith Hansen <keithshansen(a)gmail.com<mailto:keithshansen@gmail.com>> Subject: Shiva Haghighi Memorial Date: March 27, 2014 at 1:56:01 PM EDT To: Leah Jamieson <lhj(a)purdue.edu<mailto:lhj@purdue.edu>> Dean Jamieson, I hope this email finds you well. I’m not sure if you heard but Dr. Kamyar Haghighi’s daughter, Shiva, passed away last Friday from breast cancer at the age of 28. She had an undergraduate degree in Civil from Purdue and a Masters in Green/LEED design from here as well. We’ve decided to set up a memorial scholarship in Shiva's name and Amy Noah suggested I pass along the information to you to share with anyone you’d like. I’ve been using a open-source crowd funding site that doesn’t take fees to raise the money online and Amy’s setting up a fund for Shiva via the Purdue Foundation. Here’s the site with all the information: https://shivahaghighi.crowdtilt.com Best, Keith -- Keith S. Hansen Indiana University School of Medicine Cell: (765) 532-0537 | Email: kshansen(a)iupui.edu<mailto:kshansen@iupui.edu> The content of this message and/or any attachments is the private, confidential property of the sender. The use, disclosure, copying, dissemination, or distribution of the message and/or attachments content by anyone other than the intended recipient is prohibited. If you are not the intended recipient of this message please notify the sender by reply e-mail and immediately delete the message.

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Graduate Seminar Series - Dr. Deborah E. Leckband, University of Illinois at Urbana
by Heide, Karen Kay 26 Mar '14

26 Mar '14

Purdue University School of Chemical Engineering GRADUATE SEMINAR SERIES Dr. Deborah E. Leckband Reid T Milner Professor of Chemical Sciences Department of Chemistry University of Illinois at Urbana "Thermally Responsive Polymers In Biotechnology: New Perspectives On An Old Problem" Tuesday, April 1, 2014 9:00-10:30 a.m. FRNY G140 Abstract. The temperature-dependent solubility of poly(N-isopropyl acrylamide) is exploited to reversibly switch polymer interactions with proteins and cells at the lower critical solution temperature (LCAT) near 32°C. Two notable applications are cell sheet engineering and thermally programmed protein separations. Both applications hinge on achieving reversible bioadhesion to PNIPAM coatings, but a fundamental challenge has been the identification of polymer design parameters that impact reversible bioadsorption above and below the LCST. For decades, the assumption has been that thermally triggered polymer collapse and reswelling are essential for thermally reversible bioadhesion. I will present evidence that contradicts this view, but provides an alternative model consistent with current data. Surface force measurements, neutron reflectivity, and AFM imaging characterized the brush architecture as a function of the chain density, chain molecular weight, and temperature. The latter findings were in turn compared with temperature-dependent protein (and cell) adsorption and release. Qualitative comparisons of the experimental trends with theories for polymer brushes and their interactions with proteins in good and poor solvents suggests an alternative model for thermally-switchable bioadsorption, as well as design guidelines for tailoring the performance of PNIPAM coatings in these biological applications. Bio: Deborah Leckband pioneered the use of force measurements to quantify biomaterial surface properties at the molecular scale and their impact on material performance in biotechnology and the clinic. She investigated a range of materials, including water-soluble polymers, membranes, and immobilized proteins. Findings resulted in novel insights regarding how molecular scale surface forces impact many applications including drug delivery, biofouling, biosensing, and fundamental biological issues such as cell-cell cohesion. Her studies of biomaterials, in particular, often transformed long-held views on mechanisms underlying bioadhesion and how to control them.

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