December 2024 - Embrio-list

EMBRIO at NSF BII Meeting and Zoom links for Hybrid Sessions
by Ladd, Brent Thomas 17 Dec '24

17 Dec '24

Dear EMBRIOphytes, A small group of us are here in Denver representing the Institute at the NSF-BII annual meeting happening today and tomorrow (Agenda<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwhova.com…>). [https://d3ej931a0s5mcg.cloudfront.net/ced6fa63-01e6-4f17-8a5a-b73fa658b26f/…]<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwhova.com…> 2024 NSF BII Grantee & RCN Meeting hosted on Whova<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwhova.com…> December 16 – 18, 2024, Denver, CO whova.com There are a number of hybrid sessions you can connect with via zoom link which has just been shared with me for the sessions as follows: Tuesday NSF Panel (8:30-10:15am) - https://zoom.us/j/98740204129?from=addon<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fzoom.us%2…> Afternoon Session (1-3:30pm) - https://zoom.us/j/99216883301?from=addon<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fzoom.us%2…> Wednesday Morning Session (8:30-12:30pm) - https://zoom.us/j/93987448089?from=addon<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fzoom.us%2…> Afternoon Session (1-4:30pm) - https://zoom.us/j/93915957573?from=addon<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fzoom.us%2…> On site in Denver we have Linlin Li (thank you for representing us in the Early Career Researcher sessions yesterday), David Umulis, Jeremy Zartman, Stephanie Gardner, and Brent Ladd. Best, Brent Brent T. Ladd, Senior Research Program Manager, EMBRIO Institute<https://www.purdue.edu/research/embrio/> Weldon School of Biomedical Engineering, Purdue University Office: Hall for Discovery Learning and Research, Ste. 203 207 S. Martin Jischke Drive West Lafayette, IN 47907 laddb(a)purdue.edu

1 0

All-Hands Seminar Today 3PM ET, Prof. Mark Alber, “Combined multiscale modeling and experimental study of mechanisms of shape formation during tissue development and growth”
by Ladd, Brent Thomas 09 Dec '24

09 Dec '24

Dear EMBRIOphytes, Join us today at 3PM ET for our All-Hands Seminar, presented by Mark Alber, Ph.D., Distinguished Professor of Mathematics, Director of the Interdisciplinary Center for Quantitative Modeling in Biology, UC-Riverside<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Ficqmb.ucr…>, seminar title: “Combined multiscale modeling and experimental study of mechanisms of shape formation during tissue development and growth” Abstract Attached Join Zoom Meeting https://purdue-edu.zoom.us/j/99105530025?pwd=wPuFZtASboXSfD8Y9e4vsbKpcrKl5j…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Meeting ID: 991 0553 0025 Passcode: 469678 See you all there, Brent Brent T. Ladd, Senior Research Program Manager, EMBRIO Institute<https://www.purdue.edu/research/embrio/> Weldon School of Biomedical Engineering, Purdue University Office: Hall for Discovery Learning and Research, Ste. 203 207 S. Martin Jischke Drive West Lafayette, IN 47907 laddb(a)purdue.edu

1 0

Emergence Newsletter Issue 38: Dec 7, 2024
by Ladd, Brent Thomas 06 Dec '24

06 Dec '24

[cid:9cb18fbb-c66c-445c-96cb-8836a571afea] Emergence: A newsletter of discovery, education, and outreach from the EMBRIO Institute Issue 38: Dec 7, 2024 DIRECTORS’ NOTE Plan to join us for the Institute’s all-hands seminar this coming Monday, December 9, 3PM ET with Prof. Mark Alber (UC Riverside, Center for Quantitative Modeling in Biology<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Ficqmb.ucr…>) presenting “Combined multiscale modeling and experimental study of mechanisms of shape formation during tissue development and growth” (see abstract below). If you missed our previous seminar on “Development of EMBRIO as a Community of Practice” presented by Soumi Mukherjee and Emily Georgopoulos from the Gardner Lab at Purdue<https://www.bio.purdue.edu/lab/gardner/>, you can find the recording on our shared Box drive in the All-Hands Meetings Recordings folder<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fapp.box.c…>. EMBRIO investigators at Purdue – it is time it is time to post your summer research projects with the SURF program to recruit undergraduate researchers to your lab! EMBRIO will cover the faculty portion of the stipend and housing agreement. The SURF program provides an 11-week on campus research experience. Get your project posted now for consideration (details and links below). The student portal is now open, with students beginning to apply to the program. EMBRIO faculty at our partner institutions – please let your undergrads know of this opportunity to work with EMBRIO faculty on summer projects and make connections with those at Purdue. There are also a number of resources and programs available for undergraduate thinking about graduate school you may want to share with your undergraduate students (see SURF details and other info below UG Resources section). Jeffery Coulter is presenting a public talk today at 3pm in MJIS 2001 at Purdue as part of his PhD Preliminary Exam “A computational analysis of CaMKII-actin networks and their influence on dendritic spine morphology” (abstract below). Congrats to Mayesha Sahir Mim, Ph.D. Candidate in EMBRIO (Zartman Lab) at Notre Dame, on a successful defense of her Ph.D. dissertation!! "Engineering Morphogenesis through Calcium Signaling and Cellular Mechanical Mediators." We wish Mayesha the very best in the next steps of her career. The NSF Biology Integration Institutes Grantee Annual Meeting will be held December 17-18, Denver, CO. The NSF Research Coordination Network grant team with the BII’s will be hosting this year’s meeting, with goals of community building, peer learning, and future visioning for transformative scientific impact. Please check out the event website<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwhova.com…> for details on hybrid sessions, keynotes, and panels (more details below). EMBRIO members check out these conferences in 2025: Multicellular Engineered Living Systems (M-CELS) Symposium 2025. Organizers invite you to participate in the “M-CELS: Advances in Basic Research and Translational Opportunities<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Furldefens…>” symposium, which will be held on March 26-28, 2025, at the OMNI Hilton Head Resort in South Carolina, USA. July 9-13, 2025 the International Zebrafish Conference<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.izfs.…> will be held in Madison, WI. Best wishes to all as the Fall 2024 semester wraps up! David, Chris, Jeremy, Anjali, Janice, Alejandra, Elsje, and Brent QUICK LINKS All-Hands Meetings Recordings<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fapp.box.c…> Materials from Summer School & Annual Retreat<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fapp.box.c…> Institute Skills and Strengths Sharing Platform<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.goog…> Orientation to EMBRIO<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fapp.box.c…> ABIDES Cultural and Mentoring resources<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fapp.box.c…> Sign the Data Sharing Policy Agreement<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca…> EMBRIO Personnel List<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fapp.box.c…> Summer Undergraduate Research Fellowship and Resources for UG’s Thinking about Graduate School Mentoring and Summer Research (Freshman – Juniors): 1. Early Discovery Mentoring Circles - This Graduate School mentoring for freshman and sophomore students (at least 2+ years remaining in bachelor's degree) will help you build your professional network and get the insider scoop about graduate school through online mentoring circles. Discover whether you might be interested in research and get real world advice about whether graduate school is your next step! * Details: Three 1.5 hour meetings over 2 weeks in January (specific dates/times are on our website: www.engr.purdue.edu/earlydiscovery<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmx.techno…>) * Apply here by January 8, 2025: https://purdue.ca1.qualtrics.com/jfe/form/SV_5o4drtNSvIjlkKW <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmx.techno…> 2. Purdue Summer Undergraduate Research Fellowship (SURF) SURF is a 10-week-long paid research opportunity for undergraduates enrolled in US universities. * Save the Date: Purdue SURF application<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmx.techno…> opens Dec 1, 2024! * Priority deadline is Jan 15, 2025 with rolling admissions after this deadline. * SURF Program Dates: May 25- August 8, 2025 * SURF Students receive a summer stipend of $6,500 * Send any summer research questions to eur(a)purdue.edu<mailto:eur@purdue.edu?subject=Purdue%20Summer%20Research%20Question>. Also check out the Pathways Scholars cohort<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmx.techno…> of SURF, if you are interested in graduate school and a PhD. Selected Pathways Scholars receive $10k, which includes summer stipend ($6500) and is expected to cover the cost of housing ($2500 summer housing allowance) and travel (up to $1000 travel reimbursement). 3. Webinar: Grad School 101: Why Consider Graduate School? – Tuesday December 3rd, 6:00 – 7:00 p.m. eastern. Think a PhD is just for future faculty? Think again! This session demystifies what it takes to be and become a graduate student (MS and PhD), as well as how you can gain more experience to be competitive through Summer Research. Sponsored by the EngGAP Graduate School Collaborative: UC Berkeley, Carnegie Mellon University, Clarkson University, Georgia Tech, Iowa State, Lehigh University, University of Michigan, Northeastern, NYU, Purdue University, University of Florida, University of Southern California, and Wentworth Institute of Technology. Register here<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmx.techno…>. 4. Interested in Semiconductors? Join STARS (Summer Training on Awareness and Readiness for Semiconductors) at Purdue! Get paid to learn about semiconductors and grow your semiconductor training. Geared towards freshman and sophomore students but all undergraduate student ages/majors welcome to apply. * Application is open December 2024 for Summer 2025 cohort * Program Dates: from May 25 – Aug 8 2025 * $10,000 per student covers stipend, lodging, and program operating fee * Open to Purdue and External students. * Apply here: https://engineering.purdue.edu/Engr/Research/EURO/programs/stars<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmx.techno…> Learn about Graduate School (For students graduating Spring 2025): GradSchoolThriving.com<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmx.techno…> is a collection of FREE resources and insider tips that aim to support the success of graduate students. You don’t know what you don’t know… so let us help you explore information that will help you thrive in your graduate studies. This is a partnership between Purdue University, Virginia Tech, Ohio State University and the University of Oklahoma. Check out the website! Current Senior and Applying? Check out Graduate Application Requirements for Purdue here: https://www.purdue.edu/academics/ogsps/prospective/gradrequirements/westlaf…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmx.techno…> EMBRIO ABIDES (Access, Belonging, Inclusion, Diversity, Equity, Support) Dr. Anjali Iyer-Pascuzzi, EMBRIO ABIDES Director, Thrust 2 Co-Lead, and Professor at Purdue, has led and organized sessions on mentorship, project management, careers, and individual development plans that are available on the Institute’s shared Box folder under ABIDES<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fapp.box.c…>. The ABIDES program will host a talk on active mentoring for EMBRIO in January 2025 by Denise Driscoll, DEI Director, CISTAR ERC, Purdue University. STUDENT LEADERSHIP COUNCIL CORNER The Student Leadership Council has put together a resource to boost collaboration and community connection in EMBRIO. They’ve have created a platform (google slide deck<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.goog…>) where we can all share a little about who we are and what kinds of strengths we can and are willing to share with others. We kindly request that all members take a few minutes to fill out a slide for themselves. This way, we can also use this to gauge what topics would be of most value to EMBRIO for hosting workshops. The SLC welcomes new officers to represent your university and your perspective for EMBRIO. Reach out to David Gazzo (dgazzo(a)nd.edu) SLC president, for more information, and log your ideas for future topics or events<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.goog…> that the SLC could organize. Access SLC slides and documents<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fapp.box.c…>, and consider signing up to give or receive mentoring<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdocs.goog…> for/from EMBRIO trainees in helping support and orient to the EMBRIO mission and interdisciplinary framework. UPCOMING DEADLINES, IMPORTANT DATES, OPPORTUNITIES & INFO EMBRIO All-hands Meeting Schedule, Monday’s 3-4pm ET. Previous All Hands Recordings<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fapp.box.c…> Sept 2 Labor Day Sept 9 State of the Institute and open discussion Sept 23 Donny Hanjaya-Putra, Notre Dame Oct 7 & 8 Fall Break at Purdue Oct 14 Holly Goodson, Notre Dame Oct 28 Mark Alber (re-scheduled) Nov 11 Alex Dowling, Notre Dame Nov 25 Soumi Mukherjee and Emily Georgopoulos, Gardner Lab, Purdue Dec 9 Mark Alber, UC-Riverside Dec. 6, 2024: Jeffery Coulter is presenting a public talk today at 3pm in MJIS 2001 at Purdue as part of his PhD Preliminary Exam “A computational analysis of CaMKII-actin networks and their influence on dendritic spine morphology” Time: Fri. Dec. 6th at 3pmET Location: MJIS 2001 Zoom Link: https://notredame.zoom.us/j/9721071389<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.googl…> Passcode: 071389 (please send Brent advanced notices of your graduate thesis defense dates and details, so that we can announce these to the community!). Dec. 9th, 2024. EMBRIO All-Hands Seminar, December 9th, 3PM, Mark Alber, Ph.D., Distinguished Professor of Mathematics, Director of the Interdisciplinary Center for Quantitative Modeling in Biology, UC-Riverside, seminar title: “Combined multiscale modeling and experimental study of mechanisms of shape formation during tissue development and growth”. Join Zoom Meeting https://purdue-edu.zoom.us/j/99105530025?pwd=wPuFZtASboXSfD8Y9e4vsbKpcrKl5j…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Meeting ID: 991 0553 0025 Passcode: 469678 Dec. 17-18th, 2024. NSF Biology Integration Institutes Grantee Annual Meeting, December 17-18, Denver, CO. The NSF Research Coordination Network grant with the BII’s will be hosting this year’s meeting, with goals of community building, peer learning, and future visioning for transformative scientific impact. Please check out the event website<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwhova.com…> for details on hybrid sessions, keynotes, and panels (times shown in Mountain Standard time). Each BII will be presenting a lightning talk during Tuesday, Dec. 17 (Noon – 1pm ET). Contact lead organizer, Dr. Gemma Jiang (gemma.jiang(a)colostate.edu<mailto:gemma.jiang@colostate.edu> ) for the zoom link to connect to sessions. Each BII is sending a small team in person (EMBRIO will be represented by David Umulis, Jeremy Zartman, Stephanie Gardner, Linlin Li, and Brent Ladd). March 26-28, 2025. EMBRIO members check out the Multicellular Engineered Living Systems (M-CELS) Symposium 2025. Organizers invite you to participate in the “M-CELS: Advances in Basic Research and Translational Opportunities<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Furldefens…>” symposium, which will be held on March 26-28, 2025, at the OMNI Hilton Head Resort in South Carolina, USA. July 9-13, 2025. International Zebrafish Conference<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.izfs.…>. Madison, WI, USA. BME PhD Preliminary Exam Announcement for Jeffery Coulter (D. Umulis and T. Kim, Co-advisors) Everyone is invited to attend the public presentation beginning at 3:00pm. Title: A computational analysis of CaMKII-actin networks and their influence on dendritic spine morphology Date: December 6, 2024 Time: 3:00 pm Location: MJIS 2001 Committee: Taeyoon Kim (Co-advisor), David Umulis (Co-advisor), Tamara Kinzer-Ursem, Janice Evans Abstract: Dendritic spines are small protrusions on neuronal dendrites responsible for receiving and integrating the post-synaptic signals that contribute to learning and memory formation through a process known as long-term-potentiation (LTP). The changes that occur in spines during LTP can be roughly categorized as “functional" (related to the efficiency of synaptic communication) and “structural" (related to morphological changes). While these changes are closely related and are both required for proper LTP, the molecular mechanisms underlying the structural changes are not well understood. The actin cytoskeleton is the primary system responsible for regulating spine structure and earlier work has found that calcium-calmodulin protein kinase II (CaMKII) has multiple actin binding capabilities. Disruption of CaMKII activity is linked to pathological spine morphologies and improper LTP, although, elucidating how its interactions with the actin cytoskeleton might contribute to this using existing experimental or computational procedures is challenging due to the small size and the multi-scale nature of this system. Here, we plan to test the hypothesis that CaMKII plays a structural role during LTP through its ability to both sequester monomeric G-actin and bundle filamentous F-actin to regulate spine morphology. We will use an agent-based computational model of homogeneous CaMKII-actin networks to understand the relative contributions of CaMKII sequestration and bundling to network architecture. To resolve the limitations of current computational approaches, we will also present a novel hybrid, continuum-discrete modeling framework capable of describing multi-scale biological systems, such as dendritic spines, wherein biochemical reactions are coupled with filamentous networks. Using this framework, we will consider how heterogeneity of CaMKII localization and its activation by calcium (Ca$^{2+}$) following synaptic stimulation affect spine morphology. Our work will provide insight into the structural role that CaMKII plays in LTP, as well as introduce a general computational framework for studying comparable multi-scale systems. EMBRIO ALL-HANDS SEMINAR: DECEMBER 9, 3PM ET VIA ZOOM: https://purdue-edu.zoom.us/j/99105530025?pwd=wPuFZtASboXSfD8Y9e4vsbKpcrKl5j…<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-ed…> Combined multiscale modeling and experimental study of mechanisms of shape formation during tissue development and growth Mark Alber Department of Mathematics, Center for Quantitative Modeling in Biology University of California Riverside, USA The regulation and maintenance of a tissue’s shape and structure is a major outstanding question in developmental biology and plant biology. In this talk, through iterations between experiments and multiscale model simulations that include a mechanistic description of interkinetic nuclear migration, we will show that the local curvature, height, and nuclear positioning of cells in the Drosophila wing imaginal disc are defined by the concurrent patterning of actomyosin contractility, cell-ECM adhesion, ECM stiffness, and interfacial membrane tension [1]. The biologically calibrated model describing both tissue growth and morphogenesis incorporates the spatial patterning of fundamental subcellular properties. Additionally, the model implements for the first time the dynamics of interkinetic nuclear migration within the simulated pseudostratified epithelium. This includes the basal to apical motion of the nucleus, mitotic rounding, and cell division dynamics. Key characteristics of global tissue architecture, such as the local curvature of the basal wing disc epithelium, cell height, and nuclear positioning, serve as metrics for model calibration. The experiments have shown how these physical features are jointly regulated through spatiotemporal dynamics in the localization of pMyoII, β-Integrin, and ECM stiffness. As the disc grows, there are progressive changes in the patterning of key subcellular features such as actomyosin contractility. The predictions made by the model simulations agree with the observed changes in contractility and cell-ECM adhesion during wing disc morphogenesis. Multiscale modeling approach combined with experiments was also applied to studying stem cell maintenance in multilayered shoot apical meristems (SAMs) of plants which requires strict regulation of cell growth and division. In this talk, the combined approach will be demonstrated through testing three hypothesized mechanisms for the regulation of cell division plane orientation and the direction of anisotropic cell expansion in the corpus [2]. 1. Nilay Kumar, Jennifer Rangel Ambriz, Kevin Tsai, Mayesha Sahir Mim, Marycruz Flores-Flores, Weitao Chen, Jeremiah J. Zartman and Mark Alber [2024], Balancing competing effects of tissue growth and cytoskeletal regulation during Drosophila wing disc development, Nature Communications, volume 15, 2477. 2. Mikahl Banwarth-Kuhn, Kevin Rodriguez, Christian Michael, Calvin-Khang Ta, Alexander Plong, Eric Bourgain-Chang, Ali Nematbakhsh,Weitao Chen, Amit Roy-Chowdhury, G. Venugopala Reddy and Mark Alber [2022], Combined computational modeling and experimental analysis integrating chemical and mechanical signals suggests possible mechanism of shoot meristem maintenance, PLOS Computational Biology 18(6): e1010199. About the speaker: Professor Mark Alber earned his Ph.D. in mathematics at the University of Pennsylvania. He held several positions at the University of Notre Dame including most recently Vincent J. Duncan Family Chair in Applied Mathematics. He is currently Distinguished Professor in the Department of Mathematics and Director of the Center for Quantitative Modeling in Biology, University of California, Riverside. Dr. Alber was elected in 2011 Fellow of the American Association for the Advancement of Science (AAAS) and received 2024 US Fulbright Scholar Award, The Netherlands. He is currently a section editor in systems biology of PLoS Computational Biology and member of editorial board of Bulletin of Mathematical Biology. Hot Off the Press: New & Recent EMBRIO Journal Papers Let us know about new papers you want to highlight for the EMBRIO community! Check out our Google Scholar Page<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fscholar.g…> See a more complete list of Scholarly Products produced under support of EMBRIO Institute<https://www.purdue.edu/research/embrio/research/scholarly-products.php> Khan, H.F., Dutta, S., Scott, A.N., Xiao, S., Yadav, S., Chen, X., Kinzer-Ursem, T.L., Rochet, J-C., Jayant, K. *“Site-specific seeding of Lewy pathology induces distinct pre-motor cellular and dendritic vulnerabilities in the cortex”. Accepted Nov. 26, 2024, Nature Communications. REMINDER: EMBRIO Acknowledgement for Scholarly Papers and Posters. For EMBRIO related research publications, NSF requires acknowledgement of EMBRIO NSF funding for our Institute to claim the work in our reporting back to NSF. Please include the following acknowledgement in your journal and conference papers and posters: “This work is based upon efforts supported by EMBRIO Institute, contract #2120200, a National Science Foundation (NSF) Biology Integration Institute.” Awards Let us know about your grants and other awards! New Lab Members? Did you recently have new students or staff members join your EMBRIO projects? We want to add them to the listserv, Box account, demographics survey, and Personnel List for ensuring their inclusion in communications and participation. If they are not already on our Personnel spreadsheet<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fapp.box.c…> , or they have graduated, let Brent know their names and email contacts (laddb(a)purdue.edu<mailto:laddb@purdue.edu> ) Brent T. Ladd, Senior Research Program Manager, EMBRIO Institute<https://www.purdue.edu/research/embrio/> Weldon School of Biomedical Engineering, Purdue University Office: Hall for Discovery Learning and Research, Ste. 203 207 S. Martin Jischke Drive West Lafayette, IN 47907 laddb(a)purdue.edu

1 0