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BME Seminar Wednesday, March 11, 2026 3:00 – 4:00 pm, MJIS 2001 Microsoft Teams meeting Join: https://teams.microsoft.com/meet/29439842767101?p=6YaWmmFKW0hKsRNqo2<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fteams.microsoft.com%2Fmeet%2F29439842767101%3Fp%3D6YaWmmFKW0hKsRNqo2&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7Cb607dc68d9d6480625b708de7de9a42d%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639628319567%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=ZCVIjzWdAPB3Gi%2BBG4kqff%2FehQs49NbA4jYFw1qo4DQ%3D&reserved=0> Meeting ID: 294 398 427 671 01 Passcode: ox2ok3mp “Precision Nanomaterials for Cancer Immunotherapy and Bioengineering” [cid:image003.jpg@01DCAFB0.65C3D4F0] Qiangqiang Shi, PhD Postdoctoral Researcher in Bioengineering University of Pennsylvania Abstract: Precision nanomaterials are transforming bioengineering by making therapeutic function programmable and measurable in vivo. In this seminar, I will present three complementary efforts that use molecularly defined design to program biological function and enable quantitative in vivo readouts. First, I will describe prodrug-tethered lipid nanoparticles (LNPs) that couple controlled intracellular drug release with cytokine mRNA delivery to amplify antitumor immunity while improving safety. Second, I will discuss lung-targeted intravenous mRNA vaccination that redirects antigen expression to the lung to promote local immune surveillance and durable tumor protection. Third, I will introduce precision chemical barcode system for nanoparticles encoding and quantification. Together, these studies position precision and encoded nanomaterials as a new operating paradigm for nanobiomaterials. Bio: Qiangqiang Shi, is a postdoctoral researcher in Bioengineering at the University of Pennsylvania in Prof. Michael Mitchell’s laboratory. His research centers on precision nanomaterials for drug and mRNA delivery, with an emphasis on cancer immunotherapy. He develops prodrug-tethered lipid nanoparticles (LNPs) for controlled immunomodulation, lung-targeted intravenous mRNA vaccine strategies to program local anti-tumor immunity. He also develops chemical barcode system that enables built, read, and encode information into nanoparticles. He has authored first/co-first-author papers in Nature Nanotechnology, Nature Chemistry, Nature Reviews Cancer, and PNAS and other leading journals. ________________________________________________________________________________ Microsoft Teams meeting Join: https://teams.microsoft.com/meet/29439842767101?p=6YaWmmFKW0hKsRNqo2<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fteams.microsoft.com%2Fmeet%2F29439842767101%3Fp%3D6YaWmmFKW0hKsRNqo2&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7Cb607dc68d9d6480625b708de7de9a42d%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639628419945%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=%2BLgmbheYVRYkLWJoY6wx2g2pfVCjsBS2U5cfcgCU9PM%3D&reserved=0> Meeting ID: 294 398 427 671 01 Passcode: ox2ok3mp ________________________________ Need help?<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Faka.ms%2FJoinTeamsMeeting%3Fomkt%3Den-US&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7Cb607dc68d9d6480625b708de7de9a42d%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639628467796%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=A5bapRjjnRmnMIcTDAdVhFXaSdst8t7YgG9tXKgFpQQ%3D&reserved=0> | System reference<https://teams.microsoft.com/l/meetup-join/19%3ameeting_YzE4MTdlZGItYWRjMS00OWNmLTgzMTktOTczOWE5MzAxMmY5%40thread.v2/0?context=%7b%22Tid%22%3a%224130bd39-7c53-419c-b1e5-8758d6d63f21%22%2c%22Oid%22%3a%22df347d6f-ac43-4e29-a82a-129a7532453a%22%7d> Dial in by phone +1 219-293-4410,,10262219#<tel:+12192934410,,10262219> United States, Gary Find a local number<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdialin.teams.microsoft.com%2Fe6a15c08-dda2-4f4f-8bb1-75d00bf33d17%3Fid%3D10262219&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7Cb607dc68d9d6480625b708de7de9a42d%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639628505310%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=JBe1gOATUQew8fRDRX1AK53pL9JtiYqI1O0VGKsurvo%3D&reserved=0> Phone conference ID: 102 622 19# Join on a video conferencing device Tenant key: purdue@m.webex.com<mailto:purdue@m.webex.com> Video ID: 119 634 603 8 More info<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.webex.com%2Fmsteams%3Fconfid%3D1196346038%26tenantkey%3Dpurdue%26domain%3Dm.webex.com&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7Cb607dc68d9d6480625b708de7de9a42d%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639628570884%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=cIQdFyAPhJpurOiym4NSMFoG9ph5OJZSLY8cN1JfpaI%3D&reserved=0> For organizers: Meeting options<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fteams.microsoft.com%2FmeetingOptions%2F%3ForganizerId%3Ddf347d6f-ac43-4e29-a82a-129a7532453a%26tenantId%3D4130bd39-7c53-419c-b1e5-8758d6d63f21%26threadId%3D19_meeting_YzE4MTdlZGItYWRjMS00OWNmLTgzMTktOTczOWE5MzAxMmY5%40thread.v2%26messageId%3D0%26language%3Den-US&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7Cb607dc68d9d6480625b708de7de9a42d%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639628633553%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=t%2FxaR9uTggiAqOZT%2BSGq73gb7IufhO0qlWkcCJCujWA%3D&reserved=0> | Reset dial-in PIN<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdialin.teams.microsoft.com%2Fusp%2Fpstnconferencing&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7Cb607dc68d9d6480625b708de7de9a42d%7C4130bd397c53419cb1e58758d6d63f21%7C1%7C0%7C639086639628695110%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=2orEcpXfqCKEh%2BltJWPtgv63p7eyAf%2F37WMdjMDL2q4%3D&reserved=0> ________________________________________________________________________________
