[cid:image001.jpg@01D8E211.B5B7C270] BME MONDAY ROUNDTABLE OCTOBER 17, 2022 HEADS NOTE Hello Weldon School of Biomedical Engineering, Thank you to all the staff, faculty, and students who represented BME at the annual BMES meeting in San Antonio, TX. I thought that Purdue and the Weldon School were very well-represented and I heard many positive comments from other heads about the quality they are seeing at Purdue University. It was an exciting time for many of our students who went to BMES for the first time for talks, posters, and for design competitions. It was also great to work closely with our colleagues at IUPUI on strategic alignment as well as have an opportunity to work together representing the overall Purdue and Indianapolis ecosystem in biomedical engineering. This week- we have the opportunity to welcome an international speaker to the BME seminar series- where she will present on microfluidics research and applications in Biomedical Engineering. Megan Yi-Ping Ho represents the first of two speakers this fall from Hong Kong. The HK quarantine restrictions have been lifted just in time to allow for an in-person visit. With this visit, and the well-attended BMES meeting, it’s great to be returning to a greater sense of “normal.” Covid-19 is still a concern, and it has not gone away, but we have better tools to fight it and be responsive to changes as needed. Have a great week! QUICK LINKS * Flu shots UPCOMING IMPORTANT DATES Week of October 17 Mon., Oct. 17: Center for Diabetes and Metabolic Diseases Research Seminar, 12:00 noon. Shashank J. Davé, Associate Clinical Professor, Departments of Physical Medicine & Rehabilitation and Neurology will present “Lifestyle Medicine: the Basics.” Seminar will be in-person in Indianapolis and via Zoom. Tues., Oct. 18: Special Purdue Institute for Integrative Neuroscience and Weldon BME Seminar: 9:30 a.m., DLR 131 and via Zoom. Leif A. Havton, MD, PhD, Professor, Departments of Neurology and Neuroscience, Icahn School of Medicine at Mount Sinai, NY, presents “Physiologic and Fine Structural Mapping of the Peripheral Nervous System for Neuromodulation of Autonomic Function in Primates.” Tues., Oct. 18: Purdue Engineering Frontiers Lecture, 3:00-4:20 p.m. ARMS, Kurz Atrium. David H. Li, (Ret.) President, CEO and Director at Cabot Microelectronics Corporation will present “Semiconductor Boom – Industry Growth and the Opportunities Awaiting.” Wed., Oct. 19: Special BME Seminar, 9:30 a.m. in MJIS 1001 and via Zoom. Megan Yi-Ping Ho, PhD, Associate Professor of Biomedical Engineering at The Chinese University of Hong Kong will present “Microfluidics for Single Cell Applications.” Wed., Oct. 19: BME PhD Defense Announcement for Sarah Libring (L. Solorio, advisor), 12:30 p.m., MJIS 2001 or via Zoom. Title: Characterizing Interactions Between Cancer Cells and the Extracellular Matrix in Metastatic Breast Cancer through Fibronectin Accumulation Wed., Oct. 19: Frontiers in Biophysics Seminar, 1:30 p.m. via Zoom. Colin Klenthous of the University of Oxford will present “Protein-protein interactions in the Gram-negative bacterial cell envelope.” Register at: https://purdue-edu.zoom.us/meeting/register/tJUtd-2rrTlqEt28s1D20iZPi-9RRDGj... Wed., Oct. 19: Seminar for Neurotrauma and Diseases, 4:00 p.m., Hall of Discovery and Research, Room 131 and via Zoom. Antoine Jerusalem, Professor of Mechanical Engineering and Co-Director, International Brain Mechanics and Trauma Lab at Oxford University will present “The neuron, a firing machine or a multiphysics system?” Zoom link: https://bit.ly/3QN4YhL . The seminar for neurotrauma and diseases is sponsored by Plexon, a leading neuroscience technology company, and supported by the Purdue Institute for Integrative Neuroscience and Purdue Institute for Drug Discovery. Thurs., Oct. 20: Seminars in Hearing Research at Purdue (SHRP), 10:30 a.m., LYLE 1150 and via Zoom. Ed Bartlett, Professor of Biological Sciences and Biomedical Engineering will speak on Rapid assessment of Temporal Processing from the Peripheral and Central Auditory Pathway using Dynamic Amplitude Modulated Stimuli. Upcoming important deadlines and info. Tues., Oct. 25: Purdue Center for Cancer Research Monthly Series on Career Development: A Panel Discussion with Assistant Professors in Cancer Research: Graduate School, Postdoc and Beyond, 12:00-1:00 p.m. via Zoom. Register at: https://purdue-edu.zoom.us/meeting/register/tJYode2grTItGtDD5R1LYZZnCjA2rOVx... Tues., Oct. 25: Mentoring Graduate Writers Workshop for faculty and postdocs: 2:00-3:30 p.m., A good deal of research indicates that mentoring graduate students on their writing is fraught with problems. This initial workshop will share a range of best practices around mentoring and writing in the disciplines, with the hope of making mentoring graduate writers more empowered, effective, and sustainable. Details below. Wed., Oct. 26: Graduate Mentorship Seminar Series: Building Healthy Mentorship Relationships. 4:30 p.m., WALC 2051. Hear from various COE faculty members and students in a panel-led discussion on how to develop good faculty mentor-student advising relationships. Faculty members welcome! Fri., Oct. 28: Purdue Quantum Science and Engineering Institute Seminar, 10:00 a.m., BRK 2001 and via Zoom. Dr. Vladislav V. Yakovlev, Texas A&M University will present “Seeing life in a new light: From simple classical physics to quantum-enhanced imaging.” Tues., Nov. 1: Proposals due for WL-Indy Collaborative Seed Grant. (From Jay Akridge): “We are happy to announce a collaborative seed grant competition, which is focused on establishing new research collaborations between faculty located at our two campuses. Please review the attached guidelines and reach out to colleagues to start building new research collaborations. Proposals are due November 1, 2022. See attached RFP. Tues., Nov. 1: Mentoring and the Dissertation Process for faculty and postdocs, 2:00-3:30 p.m. . You must have a GoSignMeUp account to register for this free workshop. See details below. Wed., Nov. 2: COE “Celebrating our Associate Professors” Session, 11:30 a.m. This event features recently tenured associate professors making a 10-minute presentation on some aspect of their teaching/learning, research and/or engagement activities, followed by an opportunity to discuss the presented work with other colleagues in attendance. IE/BME’s very own Ramses Martinez will be one of the presenters on this date. Go to https://purdue.ca1.qualtrics.com/jfe/form/SV_4GXBqUDu1DZdTn0 to register. After registering, you will receive a confirmation email containing information about joining the meeting. Wed., Nov. 9: Graduate Mentorship Seminar Series: Diversity and Inclusion in Mentorship Relationships, 4:30 p.m., WALC 2051. Learn about how identity and culture are crucial components to recognize in faculty mentor-student advising relationships. Faculty members welcome! Wed., Nov. 9 – Sat., Nov. 12: The Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS) is a go-to conference for underrepresented groups in STEM fields. Scientific or professional development session submissions due July 29. Thurs., Nov. 10: BME Faculty Coffee Chats for Grad Students, 9:30-10:30 a.m., MJIS 3041. Faculty hosts: Hugh Lee, Taimoor Qazi, Steve Steinhubl. Potential discussion topics: ask me anything/ healthcare, academic jobs/academia, visas/international students Thurs., Dec. 8: BME Faculty Coffee Chats for Grad Students, 2:00-3:00 p.m., MJIS 2041. Faculty host: Deva Chan. Potential discussion topics: AMA work-life, teaching & diversity statements, time management PROTECT PURDUE * Fall 2022 update: Protect Purdue Fall expectations https://protect.purdue.edu/updates/fall-2022-what-you-need-to-know/ Committee Updates Academic Programs Update The spring teaching schedule is finished and attached. FYI, there are always changes before the semester starts, so the most recent version will be accessible via this pathway: \\bmelab\Office\Academic<file://bmelab/Office/Academic> Programs Office\Teaching Schedules NOTE: Spring Evening and Final Exam requests, along with textbook needs, are due to Cindy by Friday, 10/21. Look for an email containing a Course Info Form from her for your responses. Graduate Office Update COE Graduate Mentor Seminar Series In case you missed the excellent workshop this week on “Navigating Toxic Environments” with Dr. Gonzalez-Perez (Associate Dean for Diversity Initiatives) from Princeton, a recording is available (view that here<https://www.youtube.com/watch?v=iy0HaybzNIM>). This virtual seminar covered how to better identify attributes that can lead to poor mentorship relationships or environments and mitigating tips. The next seminar in this series is on Wednesday, October 26th from 4:30-5:30pm in WALC 2051! Contact Stephen McBride<mailto:mcbrid44@purdue.edu> (Assistant Director, Graduate Student Success; College of Engineering - Graduate Education) for more information on this seminar series, or anything else related to the College’s work/initiatives to support graduate students https://engineering.purdue.edu/Engr/Academics/Graduate. BME Coffee Chats We are once again hosting are faculty coffee chats for grad students. Remember, we need attendance for this event to be successful so get these on your calendars today😊. These coffee chats will attempt to accomplish some priorities that have been shared with us by you: 1. First year students—what a great opportunity to find out more about other labs and find potential mentors for your qual committee. 2. Grad student professional development—to learn/ask/chat about topics of interest to the student either about research or other topics. 3. Increase faculty involvement with graduate students outside of their own lab. 4. Help build community between grad students. Here are the dates and faculty for fall: November Date: November 10th Time: 9:30 am-10:30 am Location: MJIS 3041 Faculty hosts: Hugh Lee, Taimoor Qazi, Steve Steinhubl Potential discussion topics: ask me anything/healthcare, academic jobs/academia, visas/international students December: Date: December 8th Time: 2:00 pm-3:00 pm Location: MJIS 2041 Faculty host: Deva Chan Potential discussion topics: AMA work-life, teaching & diversity statements, time management Please plan to participate in as many as your schedule will allow. There will be free snacks and drinks included. Graduate Admissions Update 1. Graduate Diversity Visitation Program (GDVP)<https://www.purdue.edu/gradschool/diversity/programs/graduate-diversity-visitation-program/>—October 23rd-26th · Will typically host students on Monday, October 24th from 1-2 pm and will need grad students and faculty to meet with them. 2. New Application Deadline Reminder: December 1st Research Area Update The NIH OITE is pleased to offer the RAISING A RESILIENT SCIENTIST<https://www.training.nih.gov/workshops_and_trainings_for_extramural_principal_investigators> series for faculty, staff scientists, and administrators who mentor students and postdoctoral fellows in the biomedical, behavioral, and social sciences. A variety of topics will be covered with a specific focus on communication and shared problem-solving to help trainees deal with the inevitable setbacks experienced in high knowledge environments. The goal of the Raising a Resilient Scientist series is to promote the mental health and well-being of the academic research community by supporting faculty and administrators to develop self-management, relationship-management, and mentoring skills. There will be five units in the series and start on November 9th, 2022; each unit will consist of a 75-minute lecture followed by a 1-hour facilitated discussion with peers. Previous participants found participation very valuable, and the tools presented practical and actionable. Here is what those who participated in series have to say: 1. “Informative workshop that I think all faculty should be required to attend. Making this a requirement for mentoring teams for fellowship and training grants would be a great approach! They need to be invested in mentoring and training, as much as training fellows.” 2. “Thank you! I've done a lot of mentoring workshops/training but feel like this one is already taking things to another level.” 3. “This course needs to be offered again and again, such an important resource in any academic curriculum.” There is no charge for participation, but advanced registration is required. For more information, and to register, please visit our webpage<https://www.training.nih.gov/workshops_and_trainings_for_extramural_principal_investigators>. Participation in the entire series is recommended but is not required. Please do not hesitate to email us if you have any questions. Dr. Sharon L. Milgram (she/her/hers) Director, NIH Office of Intramural Training & Education NIH Office of the Director www.training.nih.gov<http://www.training.nih.gov> Resources, attachments, further information Center for Diabetes and Metabolic Diseases Research Seminar, Mon., Oct. 17, 12:00 noon. Shashank J. Davé, Assistant Residency Program Director PM&R, Associate Clinical Professor, Departments of Physical Medicine & Rehabilitation and Neurology, IU School of Medicine will present “Lifestyle Medicine: the Basics.” Seminar will be in-person in Indianapolis in R4-101and via Zoom. Zoom link: https://iu.zoom.us/j/83951671092?pwd=WC9GNTJaVTRVcEIyako4cHMvN2FXZz09 This seminar is hosted by the Indiana University Center for Diabetes and Metabolic Diseases. Special Purdue Institute for Integrative Neuroscience and Weldon BME Seminar: Tues., Oct. 18, 9:30 a.m., DLR 131. Leif A. Havton, MD, PhD, Professor, Departments of Neurology and Neuroscience, Icahn School of Medicine at Mount Sinai, NY and Staff Physician, Neurology, James J. Peters VA Medical Center, presents “Physiologic and Fine Structural Mapping of the Peripheral Nervous System for Neuromodulation of Autonomic Function in Primates.” Abstract: Dr. Havton will present recent developments in non-human primate studies of transcutaneous spinal cord stimulation (TSCS) for functional mapping of autonomic and motor functions in pelvic organs. He will also present a new anatomical tool for the correction of varied dispersion angles and myelination in light and electron microscopy as well as a new non-binary approach for the analysis of clustering of defined nerve fiber subtypes in the peripheral nervous system. Integration of detailed morphological and physiologic data will be discussed with implications for ongoing efforts to refine neuromodulation strategies to reverse conditions. Bio: Dr. Leif A Havton serves as Professor of Neurology and Neuroscience at the Icahn School of Medicine at Mount Sinai in New York, NY. He also serves as Staff Physician in Neurology and Principal Investigator at the Spinal Cord Injury Research Center at the James J Peters VA Medical Center in the Bronx, NY. The Havton research laboratory studies neural repair and plasticity after injury to the spinal cord, proximal nerve roots, and peripheral nerves, and the lab has a special interest in the recovery and restoration of motor and autonomic functions. Dr. Havton and his research team develop translational research models in small and large animals for the development of new therapeutics and refinement of available treatment strategies, including neuromodulation and cell-based approaches. The laboratory includes an anatomical platform for the development of new analytical tools with expertise in ultrastructural studies. ~Faculty Hosts: Dr. Matthew Ward, Dr. Terry Powley, and Dr. Chris Rochet~ Join Zoom Meeting: https://purdue-edu.zoom.us/j/97665921496?pwd=bzNhUFpLNUdFcW9WeWlCTmcxdzhkdz0... Purdue Engineering Frontiers Lecture, Tues., Oct. 18, 3:00-4:20 p.m. ARMS, Kurz Atrium. David H. Li, (Ret.) President, CEO and Director at Cabot Microelectronics Corporation will present “Semiconductor Boom – Industry Growth and the Opportunities Awaiting.” Following the lecture there will be a panel from 4:30-5:30 p.m. “Launching Leaders – Transitioning from Student to Professional.” The lecture and panel are hosted by the College of Engineering and Davidson School of Chemical Engineering. Special BME Seminar, Wed., Oct. 19, 9:30 a.m. in MJIS 1001 and via Zoom. Megan Yi-Ping Ho, PhD, Associate Professor of Biomedical Engineering at The Chinese University of Hong Kong will present “Microfluidics for Single Cell Applications.” Abstract: Microfluidics has gathered significant interest for biomedical applications, particularly the analysis of targeted biomolecules from minute amount of samples. This presentation will summarize our efforts on exploiting microfluidics for the manipulation and analysis of individual cells and subcellular organelles. In particular, we have explored the possibility of modulating hydrodynamic shear stress at microscale to selectively disrupt cellular membrane while maintaining the mitochondrial membrane intact. We have also investigated a microfluidics-based method to encapsulate protein payloads into red blood cells by controlling membrane deformation either transiently or extendedly in a microfluidic channel. This presentation will also highlight our recent development of a novel surfactant based on fluorinated plasmonic gold nanoparticles, rendering a previously unavailable feature of photo-responsiveness in droplet microfluidics. Looking forward, we plan to study the fundamentals of how individual cells alter their phenotypes in response to environmental and therapeutic stimuli. These efforts are expected to find clinical applications in diagnostics, prognostics and treatment evaluation of infectious and chronic diseases, as well as to expand our fundamental understanding towards disease development. Bio: Megan Yi-Ping Ho is currently an Associate Professor in the Department of Biomedical Engineering at the Chinese University of Hong Kong. She received her B.S. and M.S. in Power Mechanical Engineering from National Tsing-Hua University, Taiwan. She received her Ph.D. in Mechanical Engineering from the Johns Hopkins University in USA. After her postdoctoral training with Duke University in USA, she received the Young Elite Researcher Award from the Danish Research Council for Independent Research and started her independent career in the Interdisciplinary Nanoscience Centre and the Department of Molecular Biology & Genetics at Aarhus University in Denmark. She is a co-founder of two start-up companies situated in Demark, Zymonostics and vPCiR, focusing on enzyme-based diagnostics. She has published 67 peer-reviewed journal articles, 6 book chapters, 77 conference papers, edited 1 book and holds 2 granted patents. The results that she presented have been recognized internationally by the American Society of Gene Therapy and Controlled Release Society. Her research team is focused on developing nanosensors and microfluidics as diagnostic tools to expand the capacity of disease detection and treatment evaluation. ~BME Host: Young Kim~ Zoom link: https://purdue-edu.zoom.us/j/7731446991?pwd=RHdkZTVnRkxTM3J3dnRvY1VLWTlYUT09 BME PhD Defense Announcement for Sarah Libring (L. Solorio, advisor), Wed., Oct. 19, 12:30 p.m., MJIS 2001 or via Zoom. Title: Characterizing Interactions Between Cancer Cells and the Extracellular Matrix in Metastatic Breast Cancer through Fibronectin Accumulation Location: MJIS 2001 or Zoom: https://purdue-edu.zoom.us/j/98072942203?pwd=Y09ub3NUZndSckdPeGtYOEhIZlNMQT0... Committee: Luis Solorio (Chair), Michael K. Wendt, Hyowon (Hugh) Lee, Sherry Voytik-Harbin Abstract: Metastases are responsible for approximately 90% of all cancer-related deaths, with metastatic breast cancer (BC) holding a 5-year survival rate of only 27%. Recent research has highlighted a complex dynamic between cancer cells and the tumor microenvironment as essential for the formation of macrometastases. Within this field, tissue stiffening through matrix accumulation and altered matrix organization at the primary tumor site were recently linked with sustained proliferation and increased migration of tumor cells. Separately, elevated levels of the glycoprotein, fibronectin, were correlated to poor patient survival in BC and were linked to enhanced seeding of disseminated tumor cells at metastatic sites. Through my thesis work, we have identified several mechanisms through which accumulated fibronectin impacts the metastatic potential of BC cells. First, we identified a transient increase in extracellular fibronectin in the lungs, which peaked before overt metastasis, coupled with a non-transient increase in total lung volume. To better recapitulate physiological conditions, we then developed a novel magnetically-actuating platform with the ability to apply tensile strain on cells at various amplitudes and frequencies in a high-throughput multi-well culture plate using suspended fibrillar fibronectin for 3D cell culture that is not reliant on a synthetic substrate. Using this as a biomimetic lung model, we found that cyclic mechanical force acted as a suppressor of cancer cell growth in a biomimetic lung model, implicating the accumulation and reorganization of extracellular matrix as an attempt by the cancer cells to alter the mechanical properties of the lung tissue and resist entering dormancy. However, our results showed that BC cells could not organize extracellular fibronectin independently. Instead, BC cells altered the accumulation and architecture of fibronectin by conditioning fibroblasts through soluble factors and extracellular vesicles. We observed that the fibronectin produced by conditioned fibroblasts varied as an effect of both the method of conditioning and the phenotype of the BC cell as the conditioning source. Taken together, these results have increased our knowledge of the relationship between disseminated breast cancer cells, fibroblasts, and fibronectin architecture in the early metastatic lung niche that paves the way for further investigation on targeting disseminated BC cells during early disease intervention in order to inhibit later overt metastatic outgrowth. Seminars in Hearing Research at Purdue (SHRP), Thurs., Oct. 20, 10:30 a.m., LYLE 1150 and via Zoom. Ed Bartlett, Professor of Biological Sciences and Biomedical Engineering will speak on Rapid assessment of Temporal Processing from the Peripheral and Central Auditory Pathway using Dynamic Amplitude Modulated Stimuli. Abstract: Envelope or amplitude modulation (AM) cues in a signal are critically important for the perception of complex signals, e.g., speech. Neural coding of AM can be noninvasively probed using the envelope following response (EFR), which receives contributions from both cortical (slower fluctuations, <40 Hz) and subcortical (faster fluctuations, >100 Hz) generators. As subcortical versus cortical signatures of AM representations vary across hearing loss etiologies, the EFR has great diagnostic potential. AM representations are routinely evaluated by the temporal modulation transfer function (tMTF), which is the strength of the EFR as a function of AM frequency. Currently, tMTF is measured serially for discrete sinusoidally amplitude modulated (sAM) tones. This process is time-consuming and inefficient, impeding clinical translation. Here we present a dynamically varying AM tone (dAM) used to measure a tMTF. I will analyze the tMTF obtained with and without hearing pathologies (aging, inflammation). Methods: EEG responses were obtained using sub-dermal needle electrodes in rodent models. In rodents, carrier frequencies and amplitude modulation rates varied based on species-specific differences. Tones with dynamically varying AM, the frequency of which increased exponentially from 9 Hz to 1.5 kHz over one second, and identical carrier frequencies were also used to elicit EFRs and the tMTFs were compared. Fast Fourier transforms were used to calculate discrete EFR amplitudes. A spectrally specific frequency-demodulation-based analysis was used to calculate EFR amplitudes from dAM stimuli. Results: Robust tMTFs were obtained for discrete sAM stimuli from all species tested. Preliminary results show strong tracking of dAM envelopes in rodents, which can be used to estimate the tMTF at a fine frequency resolution. These tMTFs are comparable to those obtained using discrete sAM tones. In humans, preliminary results suggest that tracking of dAM envelopes was comparable to sAM stimuli, but only at lower modulation frequencies. Ongoing analysis is aimed at refining the dAM stimuli (trajectories, timescales) to optimize AM tracking while simultaneously reducing recording times in humans. Conclusions: These results suggest that dynamically varying AM tones can be used to efficiently estimate the tMTF. However, further optimization is needed to obtain robust tMTF estimates in humans at higher AM frequencies. When combined with spectrally specific analysis, the dAM tone can be used to substantially speed up the tMTF measuring time, paving the way for potential clinical translation. Zoom link for remote attendees: https://purdue-edu.zoom.us/j/4326340458 Meeting ID: 432 634 0458 The working SHRP schedule is available on the T32 TPAN website here: https://purdue.edu/TPAN/hearing/shrp_schedule The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts<http://ogww.mj.am/lnk/AU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo/6/a2vUEcd_J6SQbZdR8Ley5Q/aHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX2Fic3RyYWN0cw> Purdue Center for Cancer Research Monthly Series on Career Development: A Panel Discussion with Assistant Professors in Cancer Research: Graduate School, Postdoc and Beyond, Tues., Oct. 25, 12:00-1:00 p.m. via Zoom. Register at: https://purdue-edu.zoom.us/meeting/register/tJYode2grTItGtDD5R1LYZZnCjA2rOVx... Questions that you could ask the panelists: * How did you find your postdoc? * What are the secrets for a successful postdoctoral training? * How to find mentors? * How to make yourself stand out as an academic faculty candidate? * Bring your own set of questions! Panelists: Lauren Ann Metskas, Ph.D. Assistant Professor, Department of Biological Sciences Matthew Scarpelli, Ph.D. Assistant Professor, School of Health Sciences Chi Zhang, Ph.D. Assistant Professor, Department of Chemistry Check out other PCCR career development events and resources at: https://www.purdue.edu/cancer-research/training-and-education/Monthly%20Seri... Questions: yang1491@purdue.edu Mentoring Graduate Writers Workshop for faculty and postdocs: Tues., Oct. 25, 2:00-3:30 p.m., A good deal of research indicates that mentoring graduate students on their writing is fraught with problems. This initial workshop will share a range of best practices around mentoring and writing in the disciplines, with the hope of making mentoring graduate writers more empowered, effective, and sustainable. Participants will learn strategies for sound response and receive materials to take away and study. Depending on faculty interest, additional workshops will be scheduled to address needs that arise during the conversation. This workshop is for faculty and postdocs only. Register: https://gspd.gosignmeup.com/public/Course/browse?courseid=3923 Purdue Quantum Science and Engineering Institute Seminar, Fri., Oct. 28, 10:00 a.m., BRK 2001 and via Zoom. Dr. Vladislav V. Yakovlev, Texas A&M University will present “Seeing life in a new light: From simple classical physics to quantum-enhanced imaging.” Abstract: The progress of biomedical sciences depends on the availability of advanced instrumentation and imaging tools capable of attaining the state of biological systems in vivo without using exogenous markers. Mechanical forces and local elasticity play a central role in understanding physical interactions in all living systems. We demonstrate a novel way to image microscopic viscoelastic properties of biological systems using Brillouin microspectroscopy [1]. In my talk, I will discuss the ways how an old spectroscopic tool can be used for real time microscopic imaging [2-3] and provide possible solutions to long standing problems in Life Sciences and Medicine [4-6] while advancing instrumentation beyond classical limits [7]. References: [1] Zh. Meng, A. Traverso, C. Ballmann, M. Troyanova-Wood, and V. V. Yakovlev, “Seeing cells in a new light: a renaissance of Brillouin spectroscopy,” Advances in Optics and Photonics 8(2), 300-327 (2016). [2] Zh. Meng, S. C. Bustamante-Lopez, K. E. Meissner and V. V. Yakovlev, “Subcellular imaging of mechanical and chemical properties using Brillouin microspectroscopy,” Journal of Biophotonics 9(3), 201-207 (2016). [3] C. W. Ballmann, Zh. Meng, A. J. Traverso, M. O. Scully, and V. V. Yakovlev “Impulsive Brillouin microscopy,” Optica 4(1), 124-128 (2017). [4] Zh. Meng, T. Thakur, C. Chitrakar, M. K. Jaiswal, A. K. Gaharwar, and V. V. Yakovlev, “Assessment of local heterogeneity in mechanical properties of a bulk hydrogel network,” ACS Nano 11(8), 7690–7696 (2017). [5] M. Troyanova-Wood, Zh. Meng, and V. V. Yakovlev, “Differentiating melanoma and healthy tissues based on elasticity-specific Brillouin microspectroscopy,” Biomedical Optics Express 10(4), 1774-1781 (2019). [6] D. Akilbekova, V. Ogay, T. Yakupov, M. Sarsenova, B. Umbayev, A. Nurakhmetov, K. Tazhin, V. V. Yakovlev, Zh. Utegulov, “Brillouin spectroscopy and radiography for assessment of viscoelastic and regenerative properties of mammalian bones,” Journal of Biomedical Optics 23(9), 097004 (2018). [7] T Li, F Li, X Liu, VV Yakovlev, GS Agarwal, “Quantum-enhanced stimulated Brillouin scattering spectroscopy and imaging,” Optica 9(8), 959-964 (2022) Host: Prof. Alexandra Boltasseva Virtual Option: Zoom Link<https://purdue-edu.zoom.us/j/91367611800> This seminar is sponsored by the Purdue Quantum Science and Engineering Institute’s Emerging Frontiers Center Crossroads of Quantum and AI. Mentoring and the Dissertation Process for faculty and postdocs, Tues., Nov. 1, 2:00-3:30 p.m. Among the most consequential documents that writers produce in graduate school is the dissertation. Strong mentoring at specific critical junctures in the dissertation process can strengthen both the document itself and graduate students’ abilities to later support their own graduate students. Unfortunately, most faculty receive little to no training about the writing instruction central to the dissertation process, from invention to final deposit. Instead, they rely upon their own experiences producing a doctoral thesis, which might have been problematic and trauma producing or wonderful yet still mystifying. This workshop incorporates current research on graduate student writing and builds on insights about graduate student struggles that the Writing Lab gains through working with dissertation writers. Faculty will be offered actionable strategies for helping dissertation writers be more effective. The workshop also will offer faculty mentors guidance on when and how to direct their students to the Writing Lab for intensive and on-going support. This workshop is for faculty and postdocs only. You must have a GoSignMeUp account to register for this free workshop. Registration: https://gspd.gosignmeup.com/public/Course/browse?courseid=3923 Attachments SPRING 2023 class schedule BMES 2022 Mentoring Special Session Flyer How_Do_I_Register_for_a_Purdue_University_Workshop -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list
