Purdue University School of Chemical Engineering Graduate seminar series Prof. Ruben Carbonell Frank Hawkins Kenan Distinguished Professor North Carolina State University "Challenges and Recent Advances in the Purification of Biotherapeutics" September 23, 2014 9:00-10:15 a.m. FRNY G140 Reception at 10:15-10:45 a.m. in Henson Atrium Abstract: An exciting and fast growing area in medicine involves the use of proteins such as antibodies derived from genetically modified organisms to treat serious chronic diseases. Unfortunately, the high cost of development and production of these biological drugs makes them inaccessible to many individuals, especially in developing countries. There is a growing demand for faster, more efficient and safe approaches for the production of complex biotherapeutics. This seminar will describe some novel purification approaches for biologics that utilize selective small peptide ligands that recognize and bind to protein products and high throughput, high capacity membranes for product capture and purification. Bio: Ruben G. Carbonell is the Frank Hawkins Kenan Distinguished Professor of Chemical and Biomolecular Engineering at NC State University, which he joined in 1984 after 10 years in the Chemical Engineering Department at the University of California, Davis. He is the Director of both the Biomanufacturing Training and Education Center (BTEC) and the Kenan Institute for Engineering, Technology & Science at NC State. Prof. Carbonell has authored over 230 peer-reviewed publications in international journals and he has trained 77 MS and PhD students and 36 postdoctoral students during his academic career. Dr. Carbonell is a member of the National Academy of Engineering and he is a Fellow of the American Institute of Chemical Engineers, and the Industrial and Engineering Chemistry Division of the American Chemical Society. He completed his B.S. degree in Chemical Engineering from Manhattan College in 1969 and his Ph.D. in Chemical Engineering from Princeton University in 1973.