BME Seminar Distinguished Lecture Series Wednesday, October 3, 2018 9:30-10:20am MJIS 1001 Weldon School of Biomedical Engineering Purdue University “Molecular Mechanism of Cytokinesis” Thomas D. Pollard, M.D. Sterling Professor of MCDB Yale University [https://pollardlab.yale.edu/sites/default/files/resize/images/thumbnail_Thom...] Abstract: Professor Pollard’s laboratory combines microscopy, biochemistry, biophysics, molecular biology and mathematical modeling to study the mechanism cytokinesis. His lab characterized important contractile ring proteins (actin, formins, profilin, cofilin, myosin-II and anillin) and developed methods to count protein molecules in live fission yeast cells by fluorescence microscopy, measuring the numbers and dynamics of more than 20 contractile ring proteins. Recently they determined the substructure of the precursors of the contractile ring by high-speed super-resolution fluorescence microscopy of live cells. This body of quantitative data allowed the lab to formulate and test molecularly explicit mathematical models for contractile ring assembly and constriction. Simulations of these models accurately account for events in live cells and provide the physical basis for mechanistic studies of the biochemical systems that regulate the transitions in the system during the cell cycle. ~BME Faculty Host: Fang Huang~ ***Coffee and juice will be provided at West Lafayette*** -- Fang Huang Assistant Professor Weldon School of Biomedical Engineering College of Engineering, Purdue University West Lafayette, IN 47907 office: 206 S Martin Jischke Dr West Lafayette, IN 47907 Room # 2025 Phone: +1 765 494 6216
