BME PhD Preliminary Exam Announcement for Rashed Almousa (D. Xie and K. Park, co-advisors) Everyone is invited to attend the public presentation beginning at 1:00 pm. Research title: Hydrogel-coated Polyvinylchloride Surface for Enhanced Antifouling and Biofilm Resistance Thesis Committee members: Prof. Dong Xie (co-chair), Prof. Kinam Park (co-chair), Prof. Jiliang Li, Prof. Sungsoo Na Date: April 22, 2022 Time: 1:00 pm Location: https://purdue-edu.zoom.us/j/92818782481?pwd=YnZVNVl6SmpyYW0xeUVKRU5oRjE4dz0... Meeting ID: 928 1878 2481 Passcode: 849982 Abstract: Once a medical device is implanted, a series of interactions occur between the surface of the device and the body fluids where proteins start to be adsorbed on the surface which initiates cell and bacterial adhesion, and this can eventually lead to thrombus formation and bacterial contamination. Both of the two complications can significantly reduce the quality and the efficiency of the implanted device and may ultimately reduce the reliability of the implant. The polyvinylchloride (PVC) surface as a common medical material is hydrophobic and highly prone to such complications, urging researchers to develop an enhanced surface coating. Unlike other approaches of inadequate surface coating or limited antifouling polymer density and thickness, we propose to form a hydrogel that is covalently bonded on the PVC surface to significantly reduce protein adsorption, cell adhesion, and biofilm formation by a dense layer of antifouling polymers via surface-initiated polymerization. Hydrogels are prepared based on polymers having the capacity of swelling large amounts of water, which can then effectively repel proteins, cells, and bacteria. The covalently attached hydrogel will be fabricated via a conventional free-radical polymerization initiated through a biocompatible initiator or chain-transfer agent. Conventional free-radical polymerization is efficient, simple, cost-effective, and more friendly to the environment when compared to advanced polymerization methods. We believe that the successful achievement of the project will greatly impact the field of blood, cardiovascular and urological research, and the quality of health care for those requiring PVC-based medical devices and supplies in blood transfusion, cardiovascular and urological applications. ------------- Rashed Abdulaziz R Almousa is inviting you to a scheduled Zoom meeting. Topic: Prelim Exam - Rashed Almousa Time: Apr 22, 2022 01:00 PM America/Indiana/Indianapolis Join Zoom Meeting https://purdue-edu.zoom.us/j/92818782481?pwd=YnZVNVl6SmpyYW0xeUVKRU5oRjE4dz0... Meeting ID: 928 1878 2481 Passcode: 849982 One tap mobile +16465588656,,92818782481#,,,,*849982# US (New York) +13017158592,,92818782481#,,,,*849982# US (Washington DC) Dial by your location +1 646 558 8656 US (New York) +1 301 715 8592 US (Washington DC) +1 312 626 6799 US (Chicago) +1 669 900 6833 US (San Jose) +1 253 215 8782 US (Tacoma) +1 346 248 7799 US (Houston) Meeting ID: 928 1878 2481 Passcode: 849982 Find your local number: https://purdue-edu.zoom.us/u/aceyrWoQ2h