BME PhD Preliminary Exam Announcement for Rashed Almousa (D. Xie and K. Park, co-advisors)
Everyone is invited to attend the public presentation beginning at 1:00 pm.
Research title: Hydrogel-coated Polyvinylchloride Surface for Enhanced Antifouling and Biofilm
Resistance
Thesis Committee members: Prof. Dong Xie (co-chair), Prof. Kinam Park
(co-chair), Prof. Jiliang Li, Prof. Sungsoo Na
Date: April 22, 2022
Time: 1:00 pm
Meeting ID: 928 1878 2481
Passcode: 849982
Abstract:
Once a medical device is implanted, a series of interactions occur between the surface of the device and the body fluids where proteins start to be adsorbed on the surface which initiates cell and bacterial adhesion, and this can eventually
lead to thrombus formation and bacterial contamination. Both of the two complications can significantly reduce the quality and the efficiency of the implanted device and may ultimately reduce the reliability of the implant. The polyvinylchloride (PVC) surface
as a common medical material is hydrophobic and highly prone to such complications, urging researchers to develop an enhanced surface coating. Unlike other approaches of inadequate surface coating or limited antifouling polymer density and thickness, we propose
to form a hydrogel that is covalently bonded on the PVC surface to significantly reduce protein adsorption, cell adhesion, and biofilm formation by a dense layer of antifouling polymers via surface-initiated polymerization. Hydrogels are prepared based on
polymers having the capacity of swelling large amounts of water, which can then effectively repel proteins, cells, and bacteria. The covalently attached hydrogel will be fabricated via a conventional free-radical polymerization initiated through a biocompatible
initiator or chain-transfer agent. Conventional free-radical polymerization is efficient, simple, cost-effective, and more friendly to the environment when compared to advanced polymerization methods. We believe that the successful achievement of the project
will greatly impact the field of blood, cardiovascular and urological research, and the quality of health care for those requiring PVC-based medical devices and supplies in blood transfusion, cardiovascular and urological applications.
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Rashed Abdulaziz R Almousa is inviting you to a scheduled Zoom meeting.
Topic: Prelim Exam - Rashed Almousa
Time: Apr 22, 2022 01:00 PM America/Indiana/Indianapolis
Join Zoom Meeting
Meeting ID: 928 1878 2481
Passcode: 849982
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