[cid:image001.jpg@01DAD39A.4C087D20] SPECIAL BME RESEARCH SEMINAR Tuesday, July 23, 2024 9:30 - 10:30 AM, MJIS 2001 Zoom link: https://purdue-edu.zoom.us/j/92227098133?pwd=m4ETi98buoacaGPifycOq02yWILIDe.1<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F92227098133%3Fpwd%3Dm4ETi98buoacaGPifycOq02yWILIDe.1&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C244f4427a01e49d4f76608dcaa8a8679%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638572759140169326%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=bOi1VAyzGbwCg18K2zo4HOaXwI4%2FaYN1aJ2so0dd7sw%3D&reserved=0> "Designed synthesis and assembly of inorganic nanomaterials for medical and healthcare applications" [cid:image002.jpg@01DAD39A.4C087D20] Taeghwan (Tag) Hyeon Center for Nanoparticle Research, Institute for Basic Science (IBS) School of Chemical and Biological Engineering, Seoul National University, Republic of Korea Abstract: Over the last 20 years, our laboratory has focused on the designed chemical synthesis, assembly and medical applications of uniform-sized nanocrystals and related nanomaterials. We demonstrated that ceria-based nanoparticles can work as therapeutic antioxidants to treat various intractable diseases.1 MnFe2O4 & CeO2 nanoparticle-anchored mesoporous silica nanoparticles can synergistically treat rheumatoid arthritis (RA).2a Furthermore, we demonstrated that ceria nanoparticle and mesenchymal stem cell works not only individually but also cooperatively toward a comprehensive RA treatment.2b Ceria nanoparticles deposited with copper ions were synthesized for effective and synergistic antioxidant therapy to treat ischemic vascular diseases.3 Ce-DTPA complex combined with Fe-DTPA complex were utilized as non-accumulative adjuvants for treating sepsis.4 Orally deliverable iron-ceria nanotablets, where iron-ceria nanoparticles are clustered in calcium phosphate and coated with a pH-responsive polymer, can treat inflammatory bowel disease.5 We showed that CeO2/Mn3O4 nanoparticles can work as effective radio-protectant not only against acute radiation syndrome, but also for protecting salivary gland during head and neck cancer radiation treatment.6 We synthesized a lysosomal alkalizer with an iron oxide core and ceria satellites to impair lysosomal enzyme activity and autophagy for treatment of primary tumor and metastasis.7 We proposed a co-delivery system of small-molecule drugs, proteins, and nanoparticles using large-pore mesoporous silica nanoparticles to inhibit lactate metabolism and induce intracellular acidification for synergistic cancer treatment.8 We reported a heterogeneous chemodynamic therapy system based on copper-iron peroxide nanoparticles for tumor microenvironment-mediated synergistic therapy.9 We fabricated ultraflexible and/or stretchable soft-electronic and optoelectronic devices integrated with various functional nanomaterials and their applications to wearable and implantable medical and healthcare devices. We fabricated electrically conductive and elastic Ag&Au nanowire-rubber nanocomposites to treat cardiovascular diseases such as heart failure and ventricular tachyarrhythmia.10 We fabricated highly conductive and elastic nano-electrodes for their applications to healthcare and skin electronic devices.11 We synthesized a flexible/sticky electronic patch and an injectable hydrogel nanocomposite for controlled drug delivery for GBM treatment.12 ~ BME Host: Chi Hwan Lee ~ References: 1. a) "Ceria-Based Therapeutic Antioxidants for Biomedical Applications," Adv. Mater. 2023, 35, 202210819; b) "Ceria Nanoparticles that can Protect against Ischemic Stroke," Angew. Chem. Int. Ed. 2012, 51, 11039; c) "Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer's Disease," ACS Nano, 2016, 10, 2860; d) "Ceria-Zirconia Nanoparticles as Enhanced Multi-Antioxidant for Sepsis Treatment," Angew. Chem. Int. Ed. 2017, 56, 11399; e) "Ceria nanoparticle systems for selective scavenging of mitochondrial, intracellular, and extracellular reactive oxygen species in Parkinson's disease," Angew. Chem. Int. Ed. 2018, 57, 9408; f) "Magnetite/Ceria Nanoparticle Assemblies for Extracorporeal Cleansing of Amyloid-β in Alzheimer's Disease," Adv. Mater. 2018, 30, 1807965. 2. a) "Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment," ACS Nano 2019, 13, 3206. b) "Ceria nanoparticle-immobilized mesenchymal stem cell nanovesicle bridges innate and adaptive immunity for comprehensive rheumatoid arthritis treatment," Nature Nanotechnol. 2023, 18, 1502. 3. "Ceria Nanoparticles as Copper Chaperones that Activate SOD1 for Synergistic Antioxidant Therapy to Treat Ischemic Vascular Diseases," Adv. Mater. 2023, 35, 2208989. 4. "Co-Delivery of Renal Clearable Cerium Complex and Synergistic Antioxidant Iron Complex for Treating Sepsis," In revision. 5. "Orally Deliverable Iron-Ceria Nanotablets for Treatment of Inflammatory Bowel Disease," In revision. 6. "Epitaxially Strained CeO2/Mn3O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection," Adv. Mater. 2020, 32, 2001566. 7. "Cascade Catalytic Nanoparticles Selectively Alkalize Cancerous Lysosomes to Suppress Cancer Progression and Metastasis," Adv. Mater. 2023, 35, 202305394. 8. "Co-delivery of Metabolic Modulators Leads to Simultaneous Lactate Metabolism Inhibition and Intracellular Acidification for Synergistic Cancer Therapy," Adv. Mater. 2023, 35, 202305512. 9. "Enhanced Chemodynamic Therapy by Cu-Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction," ACS Nano 2022, 16, 2535. 10. "Electromechanical cardioplasty using a wrapped elasto-conductive epicardial mesh," Sci. Transl. Med. 2016, 8, 344ra86; "Highly conductive, stretchable & biocompatible Ag-Au core-shell nanowire composite for wearable and implantable bioelectronics," Nature Nano. 2018, 13, 1048; "Ventricular tachyarrhythmia treatment and prevention by subthreshold stimulation with stretchable epicardial multichannel electrode array," Sci. Adv. 2023, 9, eadf6856. 11. "Highly conductive and elastic nanomembrane for skin electronics," Science 2021, 373, 1022; "Stretchable low-impedance conductor with Ag-Au-Pt core-shell-shell nanowires and in-situ-formed Pt nanoparticles for wearable and implantable device," ACS Nano 2023, 17, 7550. 12. "Penetrative and sustained drug delivery using injectable hydrogel nanocomposites for post-surgical brain tumor treatment," ACS Nano 2023, 17, 5435. Bio: Taeghwan Hyeon is a SNU Distinguished Professor at Seoul National University (SNU) and a Director of Center for Nanoparticle Research of Institute for Basic Science (IBS). He is recognized for his outstanding contributions in scalable synthesis of uniform nanoparticles, and pioneering research in designed synthesis of inorganic nanomaterials for biomedical, energy, and soft-electronic-device applications. He was listed in Top 100 Chemists in 2011, Highly Cited Researcher (both Chem&MSE) from 2014 to 2023, and chosen as 2020 Citation Laureate in Chemistry. He received four major Korean Sci&Tech awards including 2022 Grand Prize of National Academy of Engineering of Korea, 2016 Presidential Korea's Best Scientist Award, 2012 Samsung Hoam Prize, and 2008 POSCO-T.J. Park Award. He also received 2016 IUVSTA Prize at International Vacuum Congress, and delivered Kavli Foundation Frontiers of Materials Research Lecture. He is an elected Fellow/Member of Korean Academy of Science and Technology, National Academy of Engineering of Korea, US National Academy of Engineering, Swedish Royal Academy of Engineering Sciences, Royal Society of Chemistry, and Materials Research Society. From 2010 to 2020, he served as Associate Editor of J. Am. Chem. Soc. Join Zoom Meeting https://purdue-edu.zoom.us/j/92227098133?pwd=m4ETi98buoacaGPifycOq02yWILIDe.1<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F92227098133%3Fpwd%3Dm4ETi98buoacaGPifycOq02yWILIDe.1&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C244f4427a01e49d4f76608dcaa8a8679%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638572759140169326%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=bOi1VAyzGbwCg18K2zo4HOaXwI4%2FaYN1aJ2so0dd7sw%3D&reserved=0> Meeting ID: 922 2709 8133 Passcode: 831591 -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list