BME Master's Defense Announcement for John Salvas (C. Goergen, advisor) Everyone is invited to attend the public presentation beginning at 9:00 am. Title: Quantification of left atrial and left ventricular disease progression using high-frequency ultrasound Date: March 4th Time: 9:00 am Location: MJIS 2001 or Zoom - https://purdue-edu.zoom.us/j/4941561938?omn=92885446351<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F4941561938%3Fomn%3D92885446351&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7Ca1ab4c7490ba4e4aa15008dd4fa5578c%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638754293733508725%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=wBnIGELrCzcX%2BNp0yI6yyXTEu499V2%2BRoyDHJcGmowo%3D&reserved=0> Committee: Craig Goergen (Chair), Pierre Sicard, Steven Steinhubl Abstract: Heart disease is the leading cause of death in the United States. Routine cardiac monitoring involves non-invasive imaging techniques which are also employed in clinical and preclinical research. Current echocardiographic technologies allow for robust characterization of global and regional cardiac function in a variety of cardiovascular disease states. While there is a great deal of focus on left ventricular function, left atrial function is emerging as a useful imaging biomarker to predict ventricular function and outcomes. To further explore the predictive nature of left atrial function, we employed a murine model of pressure overload and assessed the relationship between left atrial and ventricular function. Moreover, we built upon advanced four-dimensional image analysis techniques to evaluate the complex global and regional function of the left atrium not typically captured by traditional echocardiographic approaches. We then implemented these techniques in a murine model of reversible pressure overload to assess the reverse remodeling process. Furthermore, we used a similar advanced image analysis technique to monitor the progression of cardiomyopathy in empagliflozin treated and non-treated mice with Duchenne muscular dystrophy. Overall, we employ advanced imaging techniques to expand the breadth of cardiovascular research and better understand underlying cardiovascular pathophysiology. -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list