[cid:image001.jpg@01DAB0D8.1249EC70] BME WEEKLY ROUNDTABLE MAY 27, 2024 INTERIM HEAD'S NOTE What a race! I did not super follow this year's Greatest Spectacle in Racing until the race was delayed by severe weather Sunday noon. Jo read my mind by putting a picture on top. I hope you enjoyed your Memorial Day weekend. I was a bit dreading watching the Pacers surrender an 18-point lead late in the game and fell to 0-3 in the NBA Eastern Conference Finals. I have had one-on-one meetings with all the Assistant and Associate Professors with majority appointment in the department. I enjoyed these meetings. Please let me know if there is anything else you want to know from me regarding the Primary Committee evaluations. One highlight I want to provide is about this year's Purdue Day of Giving. The Weldon School of Biomedical Engineering received 41 total gifts compared to 33 last year. We were 34th on the leaderboard in terms of the total amount raised. We also won one of the hourly challenges: 50th Original Tweet using Unit Handle / Hashing - $250 for Purdue Biomedical Engineering Society! UPCOMING IMPORTANT DATES Week of May 27 Mon., May 27: Memorial Day Holiday, All offices closed. Wed., May 29: Mini Symposium with IUSM Radiology & Imaging Sciences, 2:00-5:00 p.m., Goodman Hall Auditorium, Indianapolis and via Teams. We are excited to announce a mini-symposium in Indianapolis, aimed at enhancing awareness and fostering collaboration between IUSM Radiology & Imaging Sciences and Weldon School of Biomedical Engineering. The symposium will be held on May 29th 2-5 PM at the Goodman Hall Auditorium. For those unable to attend in person, a Teams option will be available. We anticipate this event will lead to collaborations in additional areas. However, neuroimaging will serve as our initial focus area, using a bottom-up approach to initiate discussions. The symposium will feature eight 20-minute talks: four from BME (Fang Huang, Vitaliy Raz, Maria Makin, and Young Kim or Cheen Ang) and four from IUSM Radiology . We strongly encourage you to attend this important event to expand our multidisciplinary research collaborations. This will be an opportunity to learn more about research and education at IUSM Radiology & Imaging Sciences. For questions, please contact Young Kim (youngkim@purdue.edu) IMPORTANT MJIS ALERTS In case you missed this in "Purdue Today": Nursing and Pharmacy Education Building<https://www.purdue.edu/administrative-operations/news/2024/050924-nursing-pharmacy-building.php>: Construction on the new Nursing and Pharmacy Education Building, also south of Mitch Daniels Boulevard and along South Russell Street, is scheduled to begin in July. The same traffic patterns for the Life Science Ranges Phenotyping Greenhouse Building will remain in place from July through February 2025. The sidewalk and street parking along the west side of South Russell Street will also close in July and remain closed off through November 2026. The parking lot located at the southwest corner of Mitch Daniels Boulevard and Russell Street will permanently close July 22. The "parking lot located at the southwest corner of Mitch Daniels...." Is the one behind MJIS/HERL. UNIVERSITY REMINDERS New research security training and certification.<https://click.communicate.purdue.edu/?qs=b7367264abb04c4fe1c86c20991f5db7d4a3ca19b0a4f0471040798f24b87f4241be57735773a58631b425912ba2ad67da99d8a7ee83d1ea> As we continue working to safeguard Purdue-led research against inappropriate interference by foreign entities, we have introduced a new online learning module for research security training<https://click.communicate.purdue.edu/?qs=b7367264abb04c4fdb20937734d89d4964f37dfbe60953098f0b43756cc7da1820695c1af4606ad39b2e0e07371d2769a188c941fc984323> that addresses contemporary issues and satisfies new federal requirements. We ask that all researchers within the colleges of agriculture, engineering and science and the Purdue Polytechnic Institute complete this training by Sept. 1, 2024. Read more.<https://click.communicate.purdue.edu/?qs=b7367264abb04c4fe1c86c20991f5db7d4a3ca19b0a4f0471040798f24b87f4241be57735773a58631b425912ba2ad67da99d8a7ee83d1ea> Upcoming important deadlines and information Thurs., June 6: IBSC-BME Preliminary Exam Announcement for Shatha J. Mufti (R. Shi, advisor). Everyone is invited to attend the public presentation beginning at 9:30 a.m. in MJIS 2001 and via Zoom. Research Title: Investigating Alterations in Neuronal Network Dynamics, Astrocyte Reactivity, and Oxidative Stress Post-Traumatic Brain Injury Utilizing in vitro TBI-On-A-Chip Model Fri., June 7: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor, Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Fri., June 7: International Society for Applied Cardiovascular Biology Webinar, 9:00 a.m., via Zoom. Dr. Sandra Davidge, PhD, FCAHS, FRSC, Executive Director, Women and Children's Health Research Institute, Distinguished University Professor, University of Alberta, Professor, Depts. of OB/GYN and Physiology will present "Developmental origins of adult cardiovascular disease: Pre-clinical evidence towards improving outcomes." Free registration at https://isacb.wildapricot.org/event-5711321<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fisacb.wildapricot.org%2Fevent-5711321&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C96197678c2854328116e08dc7f12675a%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638524964235053024%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=J%2BWvrp%2FfkNW7%2BeGCj%2BdkbSpE1gH3F%2B0%2BPNUCvqiJQTc%3D&reserved=0>. Organized by ISACB early career members in conjunction with the ISACB Early Career, European Partnership, and Communications Committee. Tues., June 18: Abstract Submission Deadline for 10th Annual Diabetes Symposium to be held August 9, 2024 on the IU School of Medicine's Indianapolis campus. Abstract submissions are included as part of the online registration form. Please refer to the document "Guidelines for Writing an Abstract<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D13c2d0f5cfe94257980bb82421d6edde08a636f167a824debb931e71b0876509ad4627c42b952ab0ef1ca57c0006546c7713bc54a12cca53&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C96197678c2854328116e08dc7f12675a%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638524964235053024%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=j%2Fx2f8w0bNv4a1wgy2nw9y1u3%2BhWSZBvq7KdRaxlXEs%3D&reserved=0>" for recommendations on how to write an abstract. Additional instructions about formatting and submitting your abstract can be found in the general information file<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D13c2d0f5cfe942571c0729488dcb43f36908163997ddaa90439a24ad704840ab75380ba54b90e7ddfd87b1a6134d1603a6d7bd3bc04c42ba&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C96197678c2854328116e08dc7f12675a%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638524964235053024%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=SgS%2Fh6%2BQ619P5FyQBruIS%2B6a%2FZKONVk%2Fz8PtIpDvHs0%3D&reserved=0> Fri., July 19: Online Registration Deadline for 10th Annual Diabetes Symposium to be held August 9, 2024 on the IU School of Medicine's Indianapolis campus. The registration deadline to receive breakfast and lunch is Friday, July 19, 2024, at 5:00 p.m. EST. After the online registration deadline, only on-site registration the day of the Symposium will be available, and lunch will not be included for on-site registrants. Register at: https://redcap.uits.iu.edu/surveys/?s=8KMTKFPHKXCKAJK4<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fredcap.uits.iu.edu%2Fsurveys%2F%3Fs%3D8KMTKFPHKXCKAJK4&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C96197678c2854328116e08dc7f12675a%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638524964235053024%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=eGCc4YrmvucBabNgNTU%2Fzv%2BL3r1JEPrJNqQXYNxOZpE%3D&reserved=0> Resources and further information Thurs., June 6: IBSC-BME Preliminary Exam Announcement for Shatha J. Mufti (R. Shi, advisor). Everyone is invited to attend the public presentation beginning at 9:30 a.m. in MJIS 2001 and via Zoom. Research Title: Investigating Alterations in Neuronal Network Dynamics, Astrocyte Reactivity, and Oxidative Stress Post-Traumatic Brain Injury Utilizing in vitro TBI-On-A-Chip Model. Committee members: Riyi Shi (Chair, BME), Matthew Ward (BME), Yunjie Tong (BME), and GuangJun Zhang (CPB) Abstract: Traumatic brain injury (TBI) can induce critical changes in neuronal network dynamics and alter the structural and functional connectivity of affected brain regions, potentially leading to serious sequalae, such as seizures. Epileptogenesis results from a shift in network dynamics towards a hyperexcitable and highly synchronized state, which occurs after brain injury via unclear mechanisms. While in vivo TBI models offer crucial insight into pathophysiological changes occurring in the brain post-injury, it is often difficult to precisely control the injury extent (e.g., degree of tissue deformation) in animals, even with strict control of injury administration (e.g., rate of rapid acceleration injury or weight-drop). Unfortunately, this methodological-induced variation confounds experimental outcomes, further obfuscating our understanding of the mechanisms that underly injury pathologies such as seizure. To overcome these limitations by minimizing systemic confounding variables, we utilized our unique in vitro TBI-on-a-chip model to investigate changes in network dynamics and seizure-like activity (SLA) post-TBI, with relative ease of measuring functional and structural changes following injury. TBI-on-a-chip simulates concussion by applying clinically relevant, rapid acceleration injuries to murine cortical networks cultured on microelectrode arrays (MEAs), and allows real-time, cell-scale monitoring of electrophysiological and morphological changes that arise from the impact injury. Extracellular recordings of spike activity revealed that networks exposed to 10 rapidly (4-6 sec) administered 30 g impacts displayed heightened network synchronization, a hallmark of SLA. Furthermore, cross-correlation analysis revealed changes in network dynamics and neuronal firing hierarchy post-impact. Additionally, immunocytochemical studies on networks exposed to single 30, 100, and 200 g impacts showed progressive increases in the astrocyte reactivity marker, GFAP, and the lipid peroxidation product and oxidative stress marker, acrolein. Since astrocytes regulate ion and neurotransmitter concentrations in the extracellular space of synapses, and astrocyte dysfunction via increased reactivity can lead to neuronal hyperexcitability and increased susceptibility for seizures, these results suggest a potential mechanism underlying TBI-induced epilepsy. Moreover, we show that acrolein, even in the absence of injury, is capable of inducing increases in GFAP, suggesting that oxidative stress could increase astrocyte reactivity, and thereby contribute to post-TBI epilepsy. In summary, this work using the TBI-on-a-chip model could provide vital insights into functional and morphological changes in neurons and astrocytes following TBI, and enable investigation of the mechanisms underlying SLA, which could lead to the identification of potential therapeutic targets. Zoom link: https://purdue-edu.zoom.us/j/99714871016?pwd=UmJNSWh0OFRONnFUa3liT0lEd2pVQT09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F99714871016%3Fpwd%3DUmJNSWh0OFRONnFUa3liT0lEd2pVQT09&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C96197678c2854328116e08dc7f12675a%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638524964235053024%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=KAEF612C%2F6vrH3W3MIjSFDdutUyyEq8GxdQ6GAn53WA%3D&reserved=0> Fri., August 9: 10th Annual Diabetes Symposium, 8:00 a.m. to 5:00 p.m. on the IU School of Medicine's Indianapolis campus, sponsored by the Indiana University School of Medicine's Center for Diabetes and Metabolic Diseases. Registration and abstract submissions are now open! The annual Diabetes Symposium of the Center for Diabetes and Metabolic Diseases presents unique opportunities to learn from nationally recognized experts, discuss the recent scientific breakthroughs and forge relationships with potential collaborators. The 2024 Symposium will be held on Friday, August 9, on the IU School of Medicine's Indianapolis campus. We invite everyone in our CDMD community to register and participate.<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D13c2d0f5cfe94257c387ec88f559c3132fddbabb9745fd63450d639383bb0ecdf7609c652e5646752f3a0208abf98ea2244f6b5529aebe96&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C96197678c2854328116e08dc7f12675a%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638524964235053024%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=7OP%2BflP8mTAqcNzlYvsd5jJGhnVVAPyqYtT5V%2FpXysU%3D&reserved=0> This year's keynote speakers are Raghu Mirmira, MD, PhD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D13c2d0f5cfe9425759917d0b0dcf8e5ba17bf70b2556231536ea7c0e1c28b46316ec42a7f117e61b1c9f2c76cd37e8cb74bbe8d15fa62ed9&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C96197678c2854328116e08dc7f12675a%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638524964235209303%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=MMGCCP%2FURqpMt2ZNzMKR%2Bdv13kSbaj9XlDsxSu1WWLE%3D&reserved=0>, professor of medicine, vice chair for research and co-director of the Diabetes Research and Training Center at the University of Chicago, and Annemarie Hirsch, MPH, PhD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D13c2d0f5cfe94257e7f6716e253887d3f06a9932120f5a9ce040515be16d68d9001c975ed1d837408b144cf2b0af26ca7df39434a7f6332f&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C96197678c2854328116e08dc7f12675a%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638524964235209303%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=k6uHNjE3IIm1Ldw6Aa%2FyP6jvTOAs%2BOmTtai8%2FhZzKfI%3D&reserved=0>, associate professor and co-director of the Environmental Health Institute in the department of population health sciences at Johns Hopkins Bloomberg School of Public Health. In celebration of the Symposium's 10th anniversary this year, we're also pleased to present a special lecture by Corinne M. Silva, PhD<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D13c2d0f5cfe94257dcacf340d265db8702ac52d0915b906083b7a2b206bc144399704ec149826a9eaeb8be288ab480bfb0114aa2d7f4e07b&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C96197678c2854328116e08dc7f12675a%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638524964235209303%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=V1SRmyNr8iYn%2B6kIX38uGdjmkIYaF%2ByGFMcsb%2Br%2BzbA%3D&reserved=0>, program director of the division of diabetes, endocrinology and metabolic diseases at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health. In addition, there will once again be Oral Abstract Presentation sessions by trainees. Please check the general information file <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D13c2d0f5cfe942571c0729488dcb43f36908163997ddaa90439a24ad704840ab75380ba54b90e7ddfd87b1a6134d1603a6d7bd3bc04c42ba&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C96197678c2854328116e08dc7f12675a%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638524964235209303%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=u8zQGJoCdZGVUnSszwFgQCt%2BL3Tzx7qWtyOZ5LyQjpQ%3D&reserved=0> for details on how to participate. There will be four simultaneous sessions that will include 4-5 presentations based on topic. Topics are listed in the abstract submission form, and the category can be selected from the list during submission. For those who do not wish to present orally, abstracts can also be submitted to be presented as posters. Please make sure you check the correct box when you submit your abstract. We would like to encourage all trainees to submit an abstract. The main goal is to discuss your project and ideas and get feedback from colleagues. Any existing data is welcome, even if the study has just started and/or is incomplete. All trainees are invited to join one of our guest speakers for breakfast and junior faculty are also invited to attend a special afternoon session with Dr. Corinne Silva. These will be great opportunities to discuss your science, and we anticipate that you will enjoy interacting with these outstanding researchers. Please let us know if you are interested in participating in this activity when you register, and select the speaker you would like to talk to. Please note that access to sessions will be limited to official registrants of the Symposium. We hope that you will join us, share your research, and make this year's milestone Symposium an incredible one! Additional details about the Symposium's agenda and logistics will be shared before the event. Please contact Shari Parker (shupchur@iu.edu<mailto:shupchur@iu.edu?subject=>) if you have additional questions or concerns. Postdoctoral Fellow Opportunity - IUSM Emergency Medicine The laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include: (1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally. For additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Findiana.peopleadmin.com%2Fpostings%2F19651&data=05%7C02%7Cbmeroundtable-list%40ecn.purdue.edu%7C96197678c2854328116e08dc7f12675a%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638524964235209303%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=DbSjrExWN0XPXFMuAPjDrYjtKIlpHvBkKH%2BqLaGDrR0%3D&reserved=0> -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list
