[cid:image004.png@01D8C1FA.0396D130] BME MONDAY ROUNDTABLE ON TUESDAY SEPTEMBER 6, 2022 QUICK LINKS * BMES Annual Meeting Early Registration * Flu shots UPCOMING IMPORTANT DATES Week of September 5 Tues., Sept. 6: Early bird registration ends for BMES 2022 Annual Meeting, which will be held in San Antonio, Texas on October 12-15, 2022. Registration is now open! You can save a lot of money by registering early. Register here: https://s7.goeshow.com/bes/annual/2022/attendee_reg.cfm Wed., Sept. 7: Weldon School BME Seminar, 9:30 a.m. Daniel Suter, Professor of Biological Sciences at Purdue will speak on "Dynamics and Mechanics of Axonal Growth and Regeneration." Wed., Sept. 7 - Wed., Oct. 26: Flu shots available to faculty and staff. All benefits-eligible employees and dependents covered on a Purdue health plan are eligible to receive the free flu vaccine. Regardless of location, individuals coming for a flu shot should bring their Purdue University ID (PUID) card or their Anthem medical plan ID card. Full schedule here: https://www.purdue.edu/hr/CHL/Services/FluShots/Faculty-staff-flushots.php Wed., Sept. 7: Seminar for Neurotrauma and Diseases, 4:00 p.m. via Zoom. Nicholas Race, MD, PhD, University of Pittsburgh will present "Toward precision medicine for post-TBI cognitive affective and psychosocial dysfunction: A translational engineering, neuroscience and clinical perspective." Upcoming important deadlines and info. Wed., Sept. 14: BME PhD Defense Announcement for Matthew J. Thompson (D. Umulis and V. Munnamalai, Co-Chairs), 11:30 a.m., MJIS 2001 and via Zoom. Wed., Sept. 14: Diabetes Research Virtual Seminar, 2:00 p.m. via Redcap. Jeffrey Pessin, Professor of Medicine and Director of Einstein-Mount Sinai Diabetes Research Center will present "Temporal and spatial cellular heterogeneity of hepatocyte metabolism." Thurs., Sept. 15: BME PhD Defense Announcement for Jinxia Yao (Y. Tong, advisor), 2:30 p.m., MJIS 2001 and via Zoom. Mon., Sept. 19: BME PhD Preliminary Exam Announcement for Conner C. Earl (C. Goergen, advisor), 3:00 p.m., MJIS 2001 and via Zoom. Fri., Sept. 30: 7th Annual Purdue Institute for Drug Discovery Symposium, 9:00-4:30 p.m., Stewart Center Room 218A-D. Mon.-Tues., Oct. 10-11: Purdue Octoberbreak. No classes, but offices and buildings open normal hours. Tues., Oct. 11: MJIS Air Handling Shutdown beginning at 7:30 AM and lasting until approx. 3:00 PM for preventative maintenance of the building's air systems. This includes air ventilation supplies to all public, classroom and research areas, including chemical fume hoods. There should be NO chemicals used anywhere! All chemical fume hood activity should terminate by 5 PM Monday October 10th. You must make sure all chemical containers are sealed at that time. Chemical fume hoods will have notices posted - do not resume activity until BME staff have verified that work is complete, and have removed postings. Wed., Nov. 9 - Sat., Nov. 12: The Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS) is a go-to conference for underrepresented groups in STEM fields. Scientific or professional development session submissions due July 29. PROTECT PURDUE * Fall 2022 update: Protect Purdue Fall expectations https://protect.purdue.edu/updates/fall-2022-what-you-need-to-know/ Committee Updates Graduate Admissions Update 1. Purdue Engineering Virtual Graduate Showcase <https://engineering.purdue.edu/Engr/Academics/Graduate/graduate-showcase> - September 25 - 26, 2022. 2. Graduate Diversity Visitation Program (GDVP)<https://www.purdue.edu/gradschool/diversity/programs/graduate-diversity-visitation-program/>-October 23rd-26th · Will typically host students on Monday, October 24th from 1-2 pm and will need grad students and faculty to meet with them. 3. New Application Deadline Reminder: December 1st Resources, attachments, further information BMES 2022 Annual Meeting will be held in San Antonio, Texas on October 12-15, 2022. Registration is now open! You can save a lot of money by registering early - early bird registration ends September 6. Register here: https://s7.goeshow.com/bes/annual/2022/attendee_reg.cfm Weldon School BME Seminar, Wed., Sept. 7, 9:30 a.m. in MJIS 1001 or via Zoom. Daniel M. Suter, Professor of Biological Sciences at Purdue will speak on "Dynamics and Mechanics of Axonal Growth and Regeneration." Note: Students registered for the seminar are expected to attend in-person. Zoom link: https://purdue-edu.zoom.us/j/7731446991?pwd=RHdkZTVnRkxTM3J3dnRvY1VLWTlYUT09 Abstract: The research in our lab is aimed at gaining a better understanding of the molecular and cellular mechanisms of axonal growth during both nervous system development and regeneration. We are using two different model systems, cultured Aplysia neurons and whole zebrafish larvae, to determine the dynamics and mechanics of axonal growth. I will focus this presentation on two ongoing research projects in our lab. First, I will discuss our studies on mechanosensing and mechanotransduction in adhesion-mediated neuronal growth cone advance using both experimental and modeling approaches. Our results suggest that growth cones prefer softer substrates when given a choice. Second, I will talk about our recent investigations of axonal regeneration following injury. We have shown that NADPH oxidase activity is required for axonal regeneration. We are also in the process of screening a drug library for new compounds that improve regeneration after spinal cord injury. We expect that our work will not only contribute to a better understanding of the mechanisms of axonal growth but also lead to potential new therapies for spinal cord injuries. Bio: Dr. Daniel Suter studied Biology at the ETH Zurich in Switzerland, receiving a BS degree in Biological Sciences in 1988. After receiving a PhD in Biochemistry from the University of Zurich in 1995, he joined the laboratory of Dr. Paul Forscher at Yale University as a Postdoctoral fellow. During his time at Yale, Dr. Suter made significant contributions to the understanding of the underlying mechanisms of neuronal growth cone motility and guidance, using quantitative high-resolution live cell imaging techniques. In 2003, he started his own lab at Purdue University as an Assistant Professor of Biological Sciences. His independent research program is focused on the dynamics and mechanics of axonal growth during development and regeneration following injury using both Aplysia and zebrafish as model systems. Since 2017, Dr. Suter is a Professor in the Department of Biological Sciences and member of the Purdue Institute for Integrative Neuroscience at Purdue University. ~BME Faculty Host: Dr. Fang Huang ~ Seminar for Neurotrauma and Diseases, Wed., Sept. 7, 4:00 p.m. via Zoom. Nicholas Race, MD, PhD, Resident Physician-Scientist, University of Pittsburgh School of Physical Medicine and Rehabilitation will present "Toward precision medicine for post-TBI cognitive affective and psychosocial dysfunction: A translational engineering, neuroscience and clinical perspective." Zoom link: https://bit.ly/3QN4YhL This seminar will also be presented in-person in the Hall of Discovery and Learning Research, room 131. This seminar series is sponsored by the Center for Paralysis Research and Plexon Neurotechnology Systems. [ABRCMS]<http://asmusa.informz.net/z/cjUucD9taT0yNDg3MTQwJnA9MSZ1PTUxODk2NDU0OSZsaT0yNTA4NjkyNA/index.html> Share Your Expertise! The Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS)<http://asmusa.informz.net/z/cjUucD9taT0yNDg3MTQwJnA9MSZ1PTUxODk2NDU0OSZsaT0yNTA4NjkyNQ/index.html> is a go-to conference for underrepresented groups in STEM fields. Last year, ABRCMS, held virtually, brought together more than 4,000 of the best and brightest scientists for four days of innovative scientific content, informative professional development sessions, and meaningful networking opportunities. Now, here's your chance to contribute to ABRCMS 2022 - the first in-person conference since 2019! Choose to submit a scientific or professional development session proposal that will engage, educate and empower the ABRCMS community: * Do you have new or exciting research to share? A scientific session proposal could be for you! Share your in-depth insights in one of 12 scientific disciplines<http://asmusa.informz.net/z/cjUucD9taT0yNDg3MTQwJnA9MSZ1PTUxODk2NDU0OSZsaT0yNTA4NjkyNg/index.html> to a diverse audience and strengthen their knowledge of applying specific methodologies and strategies in STEM. * What's your STEM story? Inspire your audience with a professional development proposal! Share your unique perspective on pursuing advanced training and a career in the biomedical and behavioral sciences, or provide tangible takeaways that will help further the audience's educational, personal and professional trajectories. Don't miss your opportunity to join us November 9-12 in Anaheim, Calif., and add your name to the list of established scientists who have shared their work at ABRCMS. Questions? Contact abrcms@asmusa.org<mailto:abrcms@asmusa.org> Don't Forget! Abstract submission is now open<http://asmusa.informz.net/z/cjUucD9taT0yNDg3MTQwJnA9MSZ1PTUxODk2NDU0OSZsaT0yNTA4NjkzMA/index.html>! Spread the word and let your students know about this opportunity to present their science to a national audience. The deadline for abstract submissions is September 9. BME PhD Defense Announcement for Matthew J. Thompson (D. Umulis and V. Munnamalai, Co-Chairs), Wed., Sept. 14, 11:30 a.m., MJIS 2001 and via Zoom. Everyone is invited to attend the public presentation beginning at 11:30am EST. Title: Precision of Positional Information Along the Developing Cochlea Radial Axis: Linear BMP Activity Helps Set the Stage Committee: David M. Umulis, Co-Chair; Vidhya Munnamalai, Co-Chair; Srividya Iyer-Biswas; Michael G. Heinz; Tamara L. Kinzer-Ursem Abstract: Positional information encoded in signaling molecules is essential for early patterning in the prosensory domain of the developing cochlea. The cochlea contains an exquisite repeating pattern of sensory hair cells and supporting cells, and this requires precision in the morphogen signals that set the initial radial compartment boundaries, but this has not been investigated. To measure gradient formation and morphogenetic precision in developing cochlea, we developed a quantitative image analysis procedure measuring SOX2 and pSMAD1/5/9 profiles in mouse embryos at E12.5, E13.5, and E14.5. Intriguingly, we found that pSMAD1/5/9 profile forms a linear gradient in the medial ~75% of the PSD during embryonic day (E)12.5 and E13.5. This is a surprising readout of activity for a diffusive BMP4 ligand secreted from a tightly constrained lateral region, since morphogens typically form exponential or power-law gradient shapes. This is meaningful for gradient interpretation because while linear profiles offer the theoretically highest information content and distributed precision for patterning, a linear morphogen gradient has not yet been observed. In addition to the information-optimized linear profile, we found that while pSMAD1/5/9 is stable during this timeframe an accompanying gradient of SOX2 shifts dynamically. Third, we see through joint decoding maps of pSMAD1/5/9 and SOX2 that there is a high-fidelity mapping between signaling activity and position in the regions soon to become Kölliker's organ and the organ of Corti where radial patterns are more intricate. Mapping is ambiguous in the prosensory domain precursory to the outer sulcus, where cell fates are uniform. Altogether, this research provides new insights into the precision of early morphogenetic patterning cues in the radial cochlea prosensory domain. Join Zoom Meeting: https://purdue-edu.zoom.us/j/94518363803?pwd=QjQvd0x6ank0NjViODI3WW50UGRPUT0... (Meeting ID: 945 1836 3803, Passcode: 722960) Diabetes Research Virtual Seminar, Wed., Sept. 14, 2:00 p.m. via Redcap. Jeffrey Pessin, Professor of Medicine and Director of Einstein-Mount Sinai Diabetes Research Center will present "Temporal and spatial cellular heterogeneity of hepatocyte metabolism." Register here: https://redcap.link/DRC-JeffreyPessin09.14.22 Abstract: The hepatic regulation of glucose and lipid metabolism occur in a zonation selective manner with hepatocytes in the periportal region displaying greater extents of gluconeogenesis and hepatocytes in the pericentral region displaying greater extents of de novo lipogenesis. Using single cell RNAseq coupled with single molecule fluorescence in situ hydridization, we will present data demonstrating that the zonation specificity of gluconeogenic gene expression is not fixed but can vary depending on physiologic conditions. More detailed transcriptional analyses further reveals that the transcriptional activation mechanism of gluconeogenic and lipogenic gene expression are distinct. The consequences of these findings with regard to metabolic dysregulation during insulin resistance will be discussed. The Diabetes Research Virtual Seminar Series is sponsored by the Diabetes Research Centers and Centers for Diabetes Translational Research whose logos are shown below. Questions, feedback, or suggestions for future speakers? Contact us at: virtual.seminar.series@vumc.org More information can be found here: https://www.vumc.org/diabetescenter/virtual-seminar-series BME PhD Defense Announcement for Jinxia Yao (Y. Tong, advisor), Thurs., Sept. 15, 2:30 p.m., MJIS 2001 and via Zoom. Everyone is invited to attend the public presentation beginning at 2:30pm. Title: An investigation of fMRI-based perfusion biomarkers in resting state and physiological stimuli Advisory committee: Dr. Yunjie Tong (Chair), Dr. Vitaliy Rayz, Dr. Ulrike Dydak, Dr. Jean Chen Zoom link: https://purdue-edu.zoom.us/j/94745595165?pwd=NXhHekhKbXJJMzJGUTBvQ0Y4ZVpnUT0... (Meeting ID: 947 4559 5165, Passcode: 411944) Abstract: Cerebrovascular disease is the most common life-threatening neurological disease in the United States. For example, stroke is the third leading cause of death in the U.S. To support normal brain function, maintaining adequate brain perfusion (i.e., cerebral blood flow (CBF)) is important. Therefore, it is crucial to assess the brain perfusion so that early intervention can be applied if abnormal perfusion is observed. The goal of my study is to develop metrics to measure the brain perfusion by understand the brain physiology using blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) under resting state and physiological stimulus. My first and second studies focused on deriving the blood arrival time using the BOLD under resting state. In the first study, we extracted the systemic low-frequency oscillations (sLFOs) fMRI signals from the internal carotid arteries (ICA) and the superior sagittal sinus (SSS). Consistent and robust results of the ICA signals leading the SSS signals by about 5 seconds among 400 fMRI scans. This delay time could be considered as an effective perfusion biomarker that associates with the cerebral circulation time (CCT). To further explore sLFO in assessing dynamic blood flow changes during the scan, in my second study, a "carpet plot", a 2-dimensional plot (time vs. voxel) of scaled fMRI signal intensity, was reconstructed and paired with a developed slope-detection algorithm. Tilted vertical edges across which a sudden signal intensity change was observed. The edges were successfully detected by the algorithm and the averaged propagation time derived from the carpet plot matches the cerebral circulation time. Given that CO2 is a vasodilator, controlling of inhaled CO2 is able to modulate the BOLD signal, therefore, as a follow-up study, we focused on investigating the feasibility of using the CO2 modulated sLFO signal as a "natural" bolus to track the CBF with the tool developed from the second study. Meaningful and comparable transit times were derived from the CO2-MRI carpet plots. Not only the timing, the BOLD signal deformation (the waveform change) under CO2 challenge is also a very useful perfusion information, which represents how the brain react to stimulus. Therefore, my fourth study focused on characterizing the brain reaction to the CO2 stimulus to better measure the brain health. Overall, these studies deepen our understanding of fMRI signal and the derived perfusion parameters can potentially be used to assess some cerebrovascular diseases, such as stroke, ischemic brain damage, and steno-occlusive arterial disease in addition to functional activations. BME PhD Preliminary Exam Announcement for Conner C. Earl (C. Goergen, advisor), Mon., Sept. 19, 3:00 p.m., MJIS 2001 and via Zoom. Everyone is invited to the public presentation from 3:00-4:00 pm. Title: Simplified, Improved, and Automated 4D Cardiac Image Analysis Advisory committee: Craig J. Goergen, Chair; Guang Lin; Vitaliy L. Rayz; Larry W. Markham; Jonathan H. Soslow Abstract: Cardiovascular disease is the leading cause of death worldwide. Cardiac imaging is an increasingly utilized tool to help with early identification and treatment of disease, however as imaging techniques advance in complexity and application, there is a greater need for accessibility and feasibility for clinical and research use. For example, 3D and 4D imaging methods arguably provide a greater morphological and quantitative assessment of cardiac fitness, however these methods also introduce complexity to analysis and interpretation of results. Deep learning for biomedical image segmentation and classification is a promising method that could potentially be used to automate analysis and reduce complexity but requires an informed approach to do so. This proposal builds on previously developed strengths in our lab in using 4D ultrasound to evaluate mouse models of cardiac disease and 4D cardiac magnetic resonance imaging in the characterization of Duchenne muscular dystrophy-associated cardiomyopathy. Using these frameworks, we plan to simplify, improve, and automate 4D cardiac image analysis in both experimental and clinical cardiac image datasets. We hypothesize that these improvements will decrease analysis time of 4D image datasets by more than 90% and that automated image analysis will achieve >95% accuracy for both image segmentation and classification. Achieving these goals will address a growing need in cardiac imaging to provide accessible techniques and technologies to researchers and healthcare providers with the goal of improving cardiac outcomes for patients worldwide. Zoom link: https://purdue-edu.zoom.us/j/91304131947 7th Annual Purdue Institute for Drug Discovery Symposium, Friday, September 30, 9:00 a.m. - 4:30 p.m., Stewart Center Room 218A-D. Keynote speakers include Joseph Schlessinger, Yale University (Cell Signaling by Receptor Tyrosine Kinases; from Basic Principles to Cancer and other Therapies), Gunda Georg, University of Minnesota (Retinoic Acide Receptor Antagonist for Non-hormonal Male Contraception), and Philip Low, Purdue University (A New Generation of Targeted Therapies). Register here: https://purdue.ca1.qualtrics.com/jfe/form/SV_aWQOjeKOgSMQLnU Attachments BME Seminar Schedule Fall 2022 PIDD Symposium Sessions -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list
