[cid:image001.png@01D96093.33873BE0] BME MONDAY ROUNDTABLE March 27, 2023 DEPUTY HEAD'S NOTE * The Indianapolis faculty rehoming process will see its first major milestone this week. Thanks to all of you who have made great efforts to help in this ongoing process. I welcome your comments, concerns, and suggestions. * We will have two primary committee meetings to review our West Lafayette faculty. They are on April 14th and 21st. * Estelle Park has officially accepted our offer. We will welcome her to join our faculty as a tenure-track Assistant Professor beginning January 1st, 2024. Important MJIS Alert Starting Monday, May 22nd, Martin Jischke Drive will be CLOSED to all traffic. The university will be performing infrastructure repairs in the area. The street will be closed to traffic for most, if not all of the summer. When the street reopens, bike lanes will replace the on-street parking, although we do not currently have details/confirmation on the entire process yet. Stay tuned for additional details. UPCOMING IMPORTANT DATES Week of March 27 Mon., March 27: Special BME Seminar, 9:30 a.m., MJIS 2001. Joseph R. Leach, MD, PhD, Assistant Professor in Residence, Department of Radiology and Biomedical Engineering at the University of California, San Francisco, will present "Abdominal Aortic Aneurysm Assessment - Moving Beyond Measurement." Wed., March 29: BME Distinguished Seminar Series, 9:30 a.m., MJIS 1001 and via Zoom. Nimmi Ramanujam, PhD, Professor of Engineering and Professor of Cancer Pharmacology and Global Health, Duke University, will present "accelerating the Impact of Technology and Innovation for Global Cervical Cancer Prevention." Wed., March 29: Special Double Seminar, 2:00 p.m., MJIS 2001 or via Zoom. Chung-Hao Lee, Ph.D., Associate Professor, School of Aerospace and Mechanical Engineering, Gallogly College of Engineering, The University of Oklahoma will present " "Towards Personalized Endovascular Treatment of Unruptured Intracranial Aneurysms" and Bradley Bohnstedt, Ph.D., Associate Professor and Director of Neurovascular Disease, Neurosurgery Clerkship Director, Indiana University School of Medicine will present "A Brief History of Cerebral Aneurysms." Thurs., March 30: BME PhD Defense Announcement for Katherine Leyba (Dr. Craig Goergen, Advisor), 10:00 a.m., MJIS 2001 and via Zoom. Research title: Optical and Acoustic-based Imaging Methods for Quantification of Oxygenation and Strain in Murine Cardiovascular Disease Models. Thurs., March 30: Seminars in Hearing Research at Purdue (SHRP), 10:30 a.m., LYLE 1150 and via Zoom. William Salloom, Postdoctoral Fellow, USC Keck School of Medicine will present "Human Cochlear Masking and OAE Suppression Measured Using Dynamic Stimuli." Thurs., March 30-Fri., March 31: 18th Annual Garnet E. Peck Symposium, Purdue Department of Industrial and Physical Pharmacy, Stewart Center and Purdue Memorial Union. 1-1/2 day symposium to showcase advances in pharmaceutical manufacturing, with sessions focusing on biologics and small molecules. Presentations include the latest developments on excipients and continuous manufacturing, novel processing technologies as well as a poster session and 3-minute student thesis competition. Registration is now open: http://www.purdue.edu/conferences/Peck2023 . There is a $15 registration fee. See attached flyer. Upcoming important deadlines and info. Mon. Apr. 3 - Fri., Apr. 7: Grad Student Appreciation Week. Our grad students are superheroes! Let us show you how much we appreciate you! Monday - Not all heroes wear capes! Grab a token of appreciation, 3-4:00 p.m.; Tuesday - Get your POW! back with a snack, 10-11:00 a.m.; Wednesday - A SOUP-er Peer Mentoring Lunch, 11am-1pm; Thursday - Super-charge your morning! 9:30-10:30 a.m.; Friday - Grab a "Frozone" Treat! 3-4:00 p.m. See flyer for details. Mon., April 3: BME PhD Defense Announcement for Anastasiia Vasiukhina (L. Solorio, advisor), 10:00 a.m., MJIS 2001 or via Zoom. Title of presentation: Small-scale Technologies for Enhanced Diagnostics and Therapeutics. Mon., April 3: BME PhD Preliminary Exam Announcement for Neal Patel (V. Rayz, advisor), 4:00 p.m., MJIS 2001 or via Zoom. Title of presentation: Characterization of CSF flow using physics-guided enhancement of 4D flow MRI. Tues., April 4: BME PhD Defense Announcement for Jonathan Cody (E. Pienaar, advisor), 1:30 p.m., DLR 131 and via Zoom. Title of presentation: "Mathematical Modeling of Interluekin-15 Therapy for Human Immunodeficiency Virus." Wed., Apr. 5: Frontiers in Biophysics Seminar Series, 1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present "Mechanical Stability of Microtubules." Wed., April 5: IBSC-BME PhD Defense Announcement for Edmond A. Rogers (R. Shi, advisor), 10:30 a.m., via Zoom. Title of Thesis Research: Elucidating pathological correlations between Traumatic Brain Injury and Alzheimer's Disease Thurs., Apr. 6: BME Faculty and Staff Town Hall, 1:00-2:00 p.m., MJIS 2001. Arvind Raman, the next dean of Purdue's College of Engineering starting April 1, will begin hosting town halls for Purdue Engineering's academic units and listening sessions for faculty and staff in April and May. The main goal for the town halls is to seek input and advice on the College's priorities for the coming years. Faculty and staff are invited to attend the town hall of their respective academic unit. Registration is not required for the town halls. A zoom link will be provided for each unit's town hall; they will not be recorded. Thurs., Apr. 6: BME Master's Defense Announcement for Sydney Clark (C. Goergen, advisor), 9:00 a.m., MJIS 2001 or via Zoom. Title: Cardiovascular Applications of Non-Invasive Imaging. Tues., Apr. 11: Shah Family Global Innovation Lab 2023 I2D Expo, Student Poster Session, Dudley Atrium, 11:30 a.m. - 1:30 p.m., Seed Grant Showcase, WSLR 116, 2:30-4:30 p.m., Keynote and Awards, ME 1130, 5:30-7:00 p.m. Go here to register for all events and for additional information: https://engineering.purdue.edu/GEP/ShahLab/Expo2023/Expo_2023 Fri., May 12-Sat., May 13: Inaugural Krannert Cardiovascular Research Center Biennial, sponsored by the Indiana University School of Medicine at the JW Marriott and Eiteljorg Museum, Indianapolis, IN. Krannert is conducting a nationally recognized CME event May 12-13 (Fri-Sat) on Myocardial Infarction & Reperfusion Injury. We cordially invite you to join us if possible. We have a strong line up of speakers on the topic who are renowned for their decades of contributions to the field. We are hoping for an event that would capture almost 50 years of activity in the field of ischemia/reperfusion and place it in a context to chart the course forward with the goal of improving care for heart attack patients. This is a great opportunity to meet thought leaders, engage in transformative science, and hopefully be part of a journey to advance CV research. For Program Agenda & Registration, please follow the link: https://medicine.iu.edu/institutes/cardiovascular/research/biennial Thurs., May 25: Application Deadline for Trailblazers in Engineering workshop, to be held on the Purdue campus July 25-26. Trailblazers in Engineering (TBE) is a multi-day workshop focused on preparing future outstanding engineering scholars for future engineering faculty careers who are also committed to increase the success of underrepresented communities of engineers. Trailblazers in Engineering Fellows are selected not only for their outstanding scholarly achievements but also for their potential impact in expanding representation and diversity in engineering. See attached flyer for application instructions. Committee Updates Graduate Office Update Good afternoon, graduate students! I hope you enjoyed your Spring Break last week. Did you know there is a multitude of fellowship opportunities for Graduate Engineering students found on our website<https://engineering.purdue.edu/Engr/Academics/Graduate/fellowship-list>? This list includes external fellowship programs you can apply for, and each award lists eligibility requirements and a link to find out more information. For instance, here are some awards for you to consider: * ACM SIGHPC/Intel Computational & Data Science Fellowships<http://www.sighpc.org/fellowships> * Open to ALL * Field of Study: All science/engineering related to computational/data science * Education Level: Graduate only; must be less than half complete with the program * Award: $15,000 adjusted based on the country of the program for 5 years * URM and/or woman in the U.S. completing degree * Deadline: April 30 * Bloomberg Data Science<https://www.techatbloomberg.com/bloomberg-data-science-ph-d-fellowship/?fbclid=IwAR2RU6ifUiXH-PwoAm2bTIl0Z8AqP9T_0vEz8Radxb0PWNFTUqCSBesscPM> * For DACA, Legal Permanent Residents, Select Foreign Nationals, U.S. Citizens, & U.S. Visas * Deadline: April * Award includes tuition plus $35,000 stipend and $5000 for conferences * All Science/Engineering majors * Ph.D. only, full-time students, must complete their Ph.D. by 2024 * US, EU (including UK) institutions. Must do a 12-week internship in NYC or London, and attend kickoff week in the fall * Major field of computer science, math, statistics, electrical engineering, operations engineering, systems engineering, industrial engineering, or related field For more information on all of the 150+ fellowship opportunities listed, please visit: https://engineering.purdue.edu/Engr/Academics/Graduate/fellowship-list Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001). Full schedule below. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Details below. BMEGSA General Body Meetings - All BME graduate students are welcome, and encouraged to attend! Upcoming meetings: Friday, March 31st 12:30PM-1:30PM Thursday, April 20th 3:30PM-4:30PM All meetings are held in MJIS 2001 in person only. Graduate Admissions Update Fall 2022 (Fall 2023 Admit Term) BME Graduate Admissions DateDATE Activity Mar 31 Due: All PhD students to be decisioned as either admit, deny or hold April 15 Graduate applicant acceptance deadline Research Update Participants needed for a Motor Function Study, "Development of a Diagnostic System for Assessment of Motor Impairment," IRB# IRB-2022-1299. See below for details. Resources and further information Special BME Seminar, Mon., March 27, 9:30 a.m., MJIS 2001. Joseph R. Leach, MD, PhD, Assistant Professor in Residence, Department of Radiology and Biomedical Engineering at the University of California, San Francisco, will present "Abdominal Aortic Aneurysm Assessment - Moving Beyond Measurement." Abstract: Abdominal aortic aneurysms (AAA) have a pooled global prevalence of 4.8% and are most common in men 65 years or older. Small AAAs (<4 cm) are commonly asymptomatic and pose little danger, while larger AAAs have a significant risk of fatal rupture that increases with increasing aneurysm diameter. Despite decades of research elucidating the histologic and biochemical features of AAA evolution, clinicians have relatively little capacity to predict or modify AAA progression in practice - we are lacking an understanding of AAA progression on a patient-specific basis, informed by factors readily assessed during periodic imaging-based surveillance. In his talk, Dr Leach will review the current state-of-the-art in clinical AAA evaluation, and present ongoing research on a comprehensive AAA assessment in which aneurysm measurement is augmented by advanced imaging-based measures of aneurysm inflammation, biomechanics, and higher-order morphologic features. Bio: Joseph R Leach, MD PhD is an Assistant Professor in Residence in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Leach obtained his PhD in Bioengineering in 2009 from University of California -Berkeley, and completed medical school, residency, and a fellowship in abdominal imaging at UCSF prior to joining the faculty in 2018. Dr. Leach has broad clinical and research interests in vascular disease and applies advanced imaging techniques and imaging-based biomechanical modeling to better understand factors influencing disease initiation, progression, and patient outcomes. Outside of the hospital, Dr. Leach enjoys cooking for his wife, Joyce and their cats Jacks and Nigel, and is a lifelong musician and terrible dancer. ~BME Host: Vitaliy Rayz~ BME Distinguished Seminar Series, Wed., March 29, 9:30 a.m., MJIS 1001 and via Zoom. Nimmi Ramanujam, PhD, Professor of Engineering and Professor of Cancer Pharmacology and Global Health, Duke University, will present "Accelerating the Impact of Technology and Innovation for Global Cervical Cancer Prevention." Abstract: The focus of our research efforts is to improve the prevention and treatment of cancer, with an emphasis on women's cancers, which is disproportionately prevalent in low- and middle-income countries. Our global initiative strives to accelerate the impact of technology and innovation to address global health inequities, with cervical cancer prevention serving as an exemplar. Specifically, we have created an imaging device called the Pocket colposcope, which transforms the complex, costly and cumbersome clinical colposcope (for cervical cancer diagnosis) used in specialized settings to a simple, inexpensive, and hand-held device, which can be deployed in a local clinic. A companion deep learning algorithm that our team has developed has the capacity to assist primary care providers, particularly, midwives and nurses, when there is limited access to specialists. We are currently collaborating with partners in Peru to integrate our technologies into community-based models of care delivery and have been able to provide cervical cancer screening to over 2000 patients to date, with timely diagnosis and treatment/referral. Our technology initiative ensures that there is continuum of care throughout the patient journey. Biography: Dr. Nimmi Ramanujam is the Robert W. Carr Professor of Engineering and Professor of Cancer Pharmacology and Global Health at Duke University and co-program leader of the Radiation Oncology and Imaging Program (ROIP) at the Duke Cancer Institute. Dr. Ramanujam's research focuses on breast and cervical cancer. Her goals are to design innovations that enable complex referral services often reserved for hospitals to be accessible at the community/primary care level, develop technologies to see and treat women with early stage disease in one visit and to develop tools that will make cancer treatment more effective and efficient. She founded the Center for Global Women's Health Technologies (GWHT) in 2013 where she empowers trainees to create impactful solutions to improve the lives of women and girls globally. This center, since inception, has catalyzed new research activities and the development and commercialization of several technologies that advance prevention and treatment of cervical and breast cancer. She has created two companies Zenalux<http://www.zenalux.com/> and Calla Health<https://callahealthfoundation.com/> to commercialize her technologies. ~ BME Host: Jackie Linnes ~ Zoom link: https://purdue-edu.zoom.us/j/99110616268?pwd=TTNhMUJ5ZXI3M2JnQ1BMaVk4bGs0Zz0... NOTE: Students registered for the seminar are expected to attend in-person. Special Double Seminar, Wed., March 29, 2:00 p.m., MJIS 2001 or via Zoom. Chung-Hao Lee, Ph.D., Associate Professor, School of Aerospace and Mechanical Engineering, Gallogly College of Engineering, The University of Oklahoma will present " "Towards Personalized Endovascular Treatment of Unruptured Intracranial Aneurysms" and Bradley Bohnstedt, Ph.D., Associate Professor and Director of Neurovascular Disease, Neurosurgery Clerkship Director, Indiana University School of Medicine will present "A Brief History of Cerebral Aneurysms." Abstract: An intracranial aneurysm (ICA) is the focal dilatation of a brain artery, affecting about 1.3 million Americans. The ICAs, left untreated, can progressively grow, weaken the vessel wall, and eventually rupture-an unpredictable incident that causes hemorrhagic strokes, accounting for 5% of all new strokes each year. Endovascular coil embolization is the current gold standard for treating saccular ICAs. However, aneurysm recurrence can reach 44% within 5-6 years after the initial coil therapy, among which ~58% requires retreatment. Additional emerging challenges for coil embolization include recanalization and suboptimal post-implant occlusion, especially for treating ICAs with a complex 3D geometry. In the second part of this seminar, I will present our recent development of personalized embolic devices for treating unruptured saccular ICAs, that we use additive manufacturing for fabricating customizable shape memory polymer porous structure and a combined experimental/computational approach for iterative bioengineering design. Built upon the fundamental information on aneurysm characteristics derived from holistic biomechanical and hemodynamic analyses, this project will potentially lead to a cutting-edge solution for ICA embolization, allowing individual-optimized aneurysm filling and, therefore, long-lasting occlusion performance. Lee Biography: Dr. Chung-Hao Lee is an associate professor of Aerospace and Mechanical Engineering at the University of Oklahoma (OU) with his biomechanics research program addressing several clinically important cardiovascular and cerebrovascular diseases. Dr. Lee graduated with B.S. and M.S. degrees in Civil Engineering from National Taiwan University (2003 & 2005), and he received a Ph.D. in Civil Engineering (major in computational biomolecular mechanics) from UCLA in 2011. Before he joined OU, Dr. Lee was an American Heart Association postdoctoral fellow at the University of Texas at Austin. Since 2016, Dr. Lee published 58 journal papers and 5 book chapters, with his research supported by the American Heart Association Scientist Development Grant, National Institutes of Health R01 Grant (2022-2027), among others. Dr. Lee is the recipient of OU's University Distinguished Teaching Award (2020) and Vice President for Research and Partnership Research & Creative Activity Award (2022). Bohnstedt Biography: Dr. Bradley Bohnstedt is an Associate Professor of Neurosurgery at IUSM, Chief of Division of Neurovascular Disease, and Fellowship Director for Neuroendovascular and Cerebrovascular Surgery. He earned a BS degree from Manchester University and his medical degree from IUSM. Prior to coming back to IU, he was in Oklahoma for 5.5 years in Neurosurgery as the Director of Cerebrovascular and Endovascular Neurosurgery and held a position as an Assistant Professor in Neurosurgery at OUHSC. He also completed a fellowship at Goodman Campbell Brain & Spine. His current research interests include aneurysms, AVD, stroke, TIA, carotid stenosis, spinal vascular malformation, endovascular tumor treatment, robotic spine procedures and spine trauma. He has extensive experience in neurocritical care disorders and cranial neurosurgery. ~ BME Host: Hugh Lee ~ Zoom link: https://purdue-edu.zoom.us/j/93919059918?pwd=UURtUlMxc1J0UzFXWk1YMFdzaVRyZz0... BME PhD Defense Announcement for Katherine Leyba, Thurs., March 30, 10:00 a.m., MJIS 2001 and via Zoom. Research title: Optical and Acoustic-based Imaging Methods for Quantification of Oxygenation and Strain in Murine Cardiovascular Disease Models. Thesis Committee members: Dr. Craig Goergen (Chair), Dr. Fang Huang, Dr. Charles Bouman, Dr. Pierre Sicard Abstract: Cardiovascular disease (CVD) is the leading cause of death worldwide and is expected to increase direct medical costs in the U.S. to $749 billion by the year 2035. Diagnosis of CVD through imaging techniques can improve our understanding of CVD progression and its associated risks through visualization of anatomical features and biological constituents. Non-invasive imaging relies on optimal image quality for visualization of such tissue structures that can be difficult to identify and segment. While various imaging modalities are used to determine tissue characteristics, many lack the spatial resolution that optics-based imaging can provide, which can assess hemodynamic parameters in preclinical models of ischemic disease. Acoustic-based imaging can complement optics-based imaging by providing anatomical and location-specific information of tissues with greater penetration depth. Even with all the advancements in imaging technology, however, limitations still exist in non-invasively, efficiently, and accurately capturing biologically relevant information with adequate spatial and temporal resolution. Furthermore, reproducible feature extraction is difficult due to a lack of standardization in the field, making it difficult to implement when image quality varies. In this work, we implement spatial frequency domain imaging (SFDI), ultrasound, and photoacoustic imaging in preclinical models of 1) peripheral artery disease, 2) traumatic brain injury, and 3) myocardial ischemia to capture imaging biomarkers of vascular and cardiac health in longitudinal studies. We also implement deep learning on preclinical ultrasound and photoacoustic images of the cardiac left ventricle to automatically extract regions of interest to calculate radial strain and oxygen saturation. Eventually findings from this work may help improve clinical cardiovascular disease diagnosis, prognosis, and treatment. Zoom Link: https://purdue-edu.zoom.us/j/95670493593?pwd=cHV1aUJHOTRJSjlvUGx2NUhEZkw4UT0... Seminars in Hearing Research at Purdue (SHRP), Thurs., March 30, 10:30 a.m., LYLE 1150 and via Zoom. William Salloom, Postdoctoral Fellow, USC Keck School of Medicine will present "Human Cochlear Masking and OAE Suppression Measured Using Dynamic Stimuli." Abstract: Schroeder-phase complexes are stimuli that contain multiple harmonic frequency components of equal amplitude but variable starting phase, summing to produce a series of periodic linear frequency sweeps. Classic psychoacoustic studies find that upwards swept Schroeder-phase maskers are more effective maskers of tonal signals than downwards swept Schroeder-phase maskers. The psychoacoustic literature on Schroeder-phase masking interprets the dependence on sweep direction as arising not primarily from suppression, but from cochlear dispersion (phase curvature), an interpretation supported by animal measurements and physiological models. The current study investigates the effects of sweep rate and direction in normal hearing humans, both behaviorally and physiologically. For the psychoacoustic experiments, detection thresholds for tonal signals masked by upward and downward sweeps are measured as a function of sweep rate and direction. In the same subjects, stimulus-frequency otoacoustic emissions (SFOAEs) at the tone frequency are recorded using the sweep combinations from the psychoacoustic paradigm as suppressors. To the extent that the two phenomena share common generation mechanisms, we expect behavioral masking and OAE suppression to depend similarly on sweep characteristics. This year's SHRP schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule<http://ogww.mj.am/lnk/AU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo/5/VzPUtXKo0Dowllp_TK_BrQ/aHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX3NjaGVkdWxl> Titles and abstracts of all SHRP talks are here: https://purdue.edu/TPAN/hearing/shrp_abstracts<http://ogww.mj.am/lnk/AU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo/6/a2vUEcd_J6SQbZdR8Ley5Q/aHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX2Fic3RyYWN0cw> Zoom link: https://purdue-edu.zoom.us/j/4326340458 MEETINGID:4326340458 BME PhD Defense Announcement for Anastasiia Vasiukhina (L. Solorio, advisor), Mon., April 3, 10:00 a.m., MJIS 2001 or via Zoom. Title of presentation: Small-scale Technologies for Enhanced Diagnostics and Therapeutics. Committee: Luis Solorio, Chair; Craig J. Goergen; David J. Cappelleri; Yoon Yeo Abstract: Miniaturization of technologies to milli-, micro- and nanoscale offers numerous advantages for diagnostic and therapeutic biomedical applications. In comparison to their macro-scale counterparts, these small-scale systems are more portable, less invasive and less costly. They can facilitate rapid, sensitive and high throughput detection of abnormalities, help track disease progression, reduce sample consumption and improve therapeutic efficacy of drug delivery while decreasing systemic toxicity. Thus, there is clearly a need for creating innovative milli-, micro- and nanoscale tools that can uncover new possibilities in detection and treatment of various types of diseases. The overall objective of this dissertation was to develop novel small-scale technologies that could help enhance diagnostic and/or therapeutic outcomes in patients with cancer, opioid addiction and inflammatory bowel disease. First, we developed an echogenically stable nanodroplet ultrasound contrast agent with potential applications in diagnostic extravascular tumor imaging and targeted cancer therapies. Then, we created a polymer blend microsphere system that could be integrated in prescription opioid tablets to develop an abuse-deterrent formulation against smoking. Finally, we designed a release system for localized delivery of aminosalicylates from magnetically actuated millirobots in the colon to improve therapeutic outcomes in patients suffering from inflammatory bowel disease. Overall, the technologies we developed could serve as a basis for designing diagnostic and therapeutic tools that are superior to currently existing platforms. Zoom Link: https://purdue-edu.zoom.us/j/92472577791?pwd=YUxuSDVPMlV3cHFBY1lYanJPYmFWdz0... Meeting ID: 924 7257 7791, Passcode: 473469 BME PhD Preliminary Exam Announcement for Neal Patel (V. Rayz, advisor), Mon., April 3, 4:00 p.m., MJIS 2001 or via Zoom. Title of presentation: Characterization of CSF flow using physics-guided enhancement of 4D flow MRI. Committee: Vitaliy L. Rayz, Chair; Amy J. Schwichtenberg; Edward J. Delp; Michael Markel Abstract: Cerebrospinal fluid (CSF) plays a diverse role within the skull including cushioning the brain, regulating intracranial pressure, and clearing metabolic wastes via the glymphatic system. Disruptions in CSF flow have long been investigated for hydrocephalus-related diseases. Recently, changes in CSF flow have been implicated in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. It remains difficult to obtain in vivo measurements of CSF flow which would enable further study of disease initiation, progression, and treatment. Three-directional phase-contrast MR imaging (4D flow MRI) has been used to measure CSF velocities within the cerebral ventricles. However, there remain challenges in balancing acquisition time, spatiotemporal resolution, and velocity-to-noise ratio. This is complicated by the low velocities and long relaxation times associated with CSF flow. To address these challenges, we have applied physics-guided neural networks (PGNN) to super-resolve and denoise synthetic 4D flow MRI of CSF flow within the 3rd and 4th ventricles using novel loss functions. These loss functions are specifically designed to ensure that high-resolution estimations of flow fields are physically consistent and temporarily coherent. We apply these PGNN to various test cases including synthetically generated 4D flow MRI in the cerebral ventricles and vasculature, in vitro 4D flow MRI acquired at two resolutions in 3D printed phantoms of the 3rd and 4th ventricles, and in vivo 4D flow MRI in a healthy subject. Lastly, we propose to use these methods to investigate the influence of vasculature changes to CSF flow in the ventricles and associated implications to conditions such as idiopathic normal pressure hydrocephalus. Zoom link: https://iu.zoom.us/j/86147472960 BME PhD Defense Announcement for Jonathan Cody (E. Pienaar, advisor), Tues., April 4, 1:30 p.m., DLR 131 and via Zoom. Title of presentation: "Mathematical Modeling of Interluekin-15 Therapy for Human Immunodeficiency Virus." Committee: Elsje Pienaar (Major Professor), Tamara Kinzer-Ursem, Nan Kong, Shelby O'Connor, David Umulis Abstract: Interleukin-15 (IL-15) is a cytokine that promotes maintenance and activation of cytotoxic immune cells. Therapeutic IL-15 stimulates these cells to fight cancer and chronic infections, such as Human Immunodeficiency Virus (HIV). Animal models of HIV have demonstrated that IL-15 agonists can suppress the virus, but this was transient and was not observed in all cohorts. We developed a mechanistic mathematical model of IL-15 therapy of HIV to explain these differences in efficacy and to explore solutions. First, the model was applied to evaluate mitigating factors, including immune regulation, viral escape, and drug tolerance, using Akaike Information Criterion. We found that immune regulatory mechanisms could explain the viral rebound observed with continued IL-15 therapy. Next, the model was expanded to allow it to simultaneously explain both the transient viral suppression noted above and the lack of viral suppression observed in another animal cohort. In this cohort, the model suggested that higher pre-treatment viral load came with higher activation of immune cells and a balancing regulatory inhibition of cytotoxicity. Finally, we conducted stability analysis at a range of IL-15 therapeutic strengths. While there was an ideal IL-15 strength, monotherapy could not maintain viral levels below what would clinically be considered to be safely controlled. Stable viral control in the model required the combination of IL-15 with blockade of key regulatory pathways. Immune therapy of complex diseases will likely require combinations of medicines that boost the immune response at multiple key points. Mathematical models like this can expedite development of these treatments. Place: Hall for Discovery and Learning Research DLR 131 and on Zoom https://purdue-edu.zoom.us/j/94454650628?pwd=ZnFUWkJCSXFtSER4VlVPS2xqeVlJQT0... Frontiers in Biophysics Seminar Series, Wed., Apr. 5, 1:30 p.m. in MJIS 1001. Joe Howard, the Eugene Higgins Professor of Molecular Biophysics and Biochemistry, Department of Molecular Biophysics and Biochemistry, Yale University, will present "Mechanical Stability of Microtubules." Microtubules are rigid polymers of tubulin that give structure to cells and serve as tracks for molecular motors. Until recently, the growth and shrinkage of microtubules was thought to be confined to their ends. Over the last few years, however, evidence has emerged that exchange of tubulin in and out of microtubules can take place within the lattice and not just at the ends. I will present our recent work on the microtubule severing protein spastin on microtubule dynamics as well as measurements of the forces necessary to remove tubulin from the lattice. This seminar is sponsored by the Molecular Biophysics Training Program (MBTP), Structural and Computational Biology and Biophysics (SCBB) and the Weldon School of Biomedical Engineering. IBSC-BME PhD Defense Announcement for Edmond A. Rogers (R. Shi, advisor), Wed., April 5, 10:30 a.m., via Zoom. Title of Thesis Research: Elucidating pathological correlations between Traumatic Brain Injury and Alzheimer's Disease. Committee: Major Professor: Dr. Riyi Shi, M.D., Ph.D.; Dr. Fang Huang, Ph.D.; Dr. Joesph Rispoli, Ph.D.; Dr. GuangJun Zhang, M.D., Ph.D. Abstract: Traumatic Brain Injuries (TBI) are a major cause of disability and death in the United States. One of the greatest consequences of the disease is the resulting long-term damage, especially in milder injuries where the damage is initially subclinical and thus lacking acutely observable manifestations that over time can compound significantly. Among these chronic issues, Alzheimer's Disease (AD) could be the most serious. While multiple studies demonstrate an increased likelihood of developing neurodegenerative diseases in response to TBI, the underlying mechanisms remain undefined and limited treatment options are currently available. Multiple hypotheses have been postulated based on various animal and clinical models, contributing a great deal to our current knowledge base and implicating several related-targets of interest (i.g. oxidative stress, inflammation, proteostasis-disruptions). While extremely valuable, these in vivo examinations are physiologically and ethically complex: there is currently no model capable of separating and visualizing TBI-induced sub-cellular damage in the moments immediately following injury, and the associated long-term changes. Further, no mechanistic study has been performed to link mechanical-trauma independently with neurodegeneration initiation via protein aggregation. It is clear that additional investigative tools are needed to rectify these intricate issues, and while in vitro methodologies generally offer the type of resolution required, no such model replicates these phenomena. Therefore, we introduce the "TBI-on-a-chip" in vitro concussive model, with a series of concomitant targeted-experiments to address this urgent, currently unmet need. Utilizing TBI-on-a-chip, we directly observe evidence of impact-induced functional and biochemical consequences, while isolating oxidative stress as a key, contributing component. Zoom link: https://purdue-edu.zoom.us/j/97333625618 BME Master's Defense Announcement for Sydney Clark (C. Goergen, advisor), Thurs., Apr. 6, 9:00 a.m., MJIS 2001 or via Zoom. Title: Cardiovascular Applications of Non-Invasive Imaging. Thesis Committee: Craig J. Goergen, Chair; Steven R. Steinhubl; Gregory J. Loomis Abstract: Cardiovascular disease has been the leading cause of death in the United States for over 70 years. To evaluate the extent and progression of cardiovascular disease, non-invasive imaging techniques are frequently used clinically and pre-clinically. Current echocardiographic and cine magnetic resonance approaches rely on measurements that are typically obtained from two-dimensional images, which assumes uniformity of the structure being evaluated. To explore methods to potentially address these shortcomings, our group has developed and validated high frequency four-dimensional ultrasound techniques as well as created a software toolbox that allows for measurement of myocardial kinematics. In this thesis, I assisted in the application of these methods to two murine models of disease states: myocardial infarction and aortic aneurysm. Another study I aided in focused on cardiac magnetic resonance imaging data from patients with Duchenne muscular dystrophy. From our software, we are able to obtain various strain and strain rate estimates that reveal significant functional changes in infarction and Duchenne muscular dystrophy earlier than standard measurement techniques. Furthermore, we are able to identify vascular expansion, transmural thickening, and changes in hemodynamics prior to aneurysm development. Earlier detection and localization allows for more targeted surveillance and interventions, which ultimately may result in improved clinical outcomes. Ideally, these findings can be used to expand the capabilities of cardiac research and the development of clinically applicable imaging techniques and treatments to better address underlying cardiovascular pathophysiology. Zoom link: https://iu.zoom.us/j/89684973230 Participants Needed for Research Study: (Aditya Shanghavi is a graduate student in Biomedical Engineering at Purdue.) I am currently working on a research project under the direction of my advisor, Dr Anne Sereno. We are inviting you to participate in a brief arm movement study. We are specifically looking for participants aged 45-85 with no history of neurological diseases who are fluent in English and have adequate hearing (with or without amplification) to process verbal instruction and adequate vision to see the computer screen. Participants should be able to perform simple upper arm motions without experiencing major pain or discomfort. We will use non-invasive motion sensors on a wristband to collect arm motion signals during normal and simulated abnormal movements (after viewing short videos) as well as an eye tracker to collect eye motion signals during a prosaccade-antisaccade task. This study's goal is to develop algorithms to detect latencies and amplitudes of movements and to quantify the sensitivity, reliability, and accuracy of the sensors and these algorithms to differentiate normal versus simulated abnormal movements. The study should take no more than 60 minutes and it will be conducted in PSYCH 3125. We will highly appreciate you taking time out of your busy schedule and will compensate you $15 for your help in our research study in addition to our heartfelt gratitude. This study is conducted in accordance with IRB # IRB-2022-1299. If you have more questions regarding this study, please contact Aditya Shanghavi at ashangha@purdue.edu<mailto:ashangha@purdue.edu>. New Course for Fall 2023: BME 69500 Pediatric Medical Devices (CRN 14011). Fall 2023, 3.0 credit hours Wednesdays 11:30-2:20 in MJIS 1083 (in person attendance only) Prerequisite: BME Graduate Standing Course Description: The unique medical needs of pediatric patients in the context of current and emerging clinical technologies are presented in this novel course. Anatomical, physiological, and pathophysiological underpinnings of diseases in infants and children are studied. Unique aspects of pediatric device design, regulation, and translation, including clinical studies and ethical considerations, are explored. Numerous clinical sub specialties such as cardiology, surgery, nephrology, pulmonology, and gastroenterology are examined in terms of technology adoption and remaining clinical needs. Future directions in device development and emerging trends in patient care are considered throughout. Weekly Course Topics: August 23 Pediatrics Introduction August 30 Neonatology Introduction September 6 Pediatric Device Design and Development I September 13 Pediatric Device Design and Development II September 20 Pediatric Device Regulation September 27 Pediatric Clinical Studies October 4 Pediatric Cardiology October 18 Pediatric Cardiovascular Surgery October 25 Pediatric Nephrology November 1 Pediatric Pulmonology November 8 Pediatric Wound Healing November 15 Pediatric Gastroenterology November 29 Ethical Considerations in Pediatrics December 6 Future Directions and Trends Primary Instructor: George Wodicka, MJIS 3036, wodicka@purdue.edu Numerous experts from the Indiana University School of Medicine Department of Pediatrics, Riley Hospital for Children, and Cook Medical, Inc. will actively participate. Spring 2023 BME Seminar Schedule (Wednesdays, 9:30 a.m. in MJIS 1001) Week Date Speaker Host Week 11 3/29/2023 Dr. Nimmi Ramanujam Robert W. Carr Professor of Biomedical Engineering, Department of Pharmacology and Cell Biology, Director of The Center for Global Women's Health Technologies, Duke University Dr. Jackie Linnes Week 12 4/5/2023 Dr. Junhong Chen Crown Family Professor of Molecular Engineering and Lead Water Strategist at Argonne National Laboratory Dr. Chi Hwan Lee Week 13 4/12/2023 Dr. Chien-Chi Lin Thomas J. Linnemeier Guidant Foundation Endowed Chair & Professor of BME at IUPUI Dr. Young Kim Week 14 4/19/2023 Dr. Rachel Surowiec Assistant Professor of BME at IUPUI Dr. Young Kim Week 15 4/26/2023 Dr. James Moon J. G. Searle Professor, Pharmaceutical Sciences Professor, Biomedical Engineering at Michigan Dr. Chi Hwan Lee The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts<http://ogww.mj.am/lnk/AU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo/6/a2vUEcd_J6SQbZdR8Ley5Q/aHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX2Fic3RyYWN0cw> Attachments Peck_flyer Trailblazers-in-Engineering Grad Appreciation Week ShahFamilyGlobalI2DExpo -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list
