BME Master's Defense Announcement for Kevin Bautista (Jacqueline Linnes, advisor) Everyone is invited to attend the public presentation beginning at 1:00 PM EST. Title: A Miniaturized Potentiostat for Electrochemical Impedance Spectroscopy Date: 04/01/2024 Time: 1:00 PM EST – 3:00 PM EST Room: MRGN 129 Zoom link: https://purdue-edu.zoom.us/j/95371010513?pwd=VW1vZXVJZ0crT0ViSGR4ZUtvUGVrdz09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F95371010513%3Fpwd%3DVW1vZXVJZ0crT0ViSGR4ZUtvUGVrdz09&data=05%7C02%7Cbmegradstudents-list%40ecn.purdue.edu%7Cfb42c0b7801246d9bc0f08dc4a740dd3%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638467109561628634%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=L6614BISuOeWEUtRzYMWwHI%2Btaoogy7tgFIPwt1fnlQ%3D&reserved=0> Committee: Dr. Jacqueline Linnes (Chair) Dr. Lia Stanciu Dr. D. Marshall Porterfield Abstract: Portable sensing enables an enhanced form of disease monitoring due to its accessible form-factors, low costs, and insights into user health, along with enhanced detection methods due to its many use cases for at-home or in-field applications. To that end, electrochemistry has been a widely used technique in characterization, detection, and diagnostics. Electrochemical Impedance Spectroscopy (EIS), is an electrochemical technique that enables electrode surface characterization through changes in impedance across a given frequency range making it sensitive to interactions at the electrode surface and enabling the detection and quantification of analytes. While EIS has been traditionally limited to benchtop potentiostats, advancements in integrated circuits (ICs) have since enabled the miniaturization of potentiostats for at-home or field applications. However, implementation of EIS in a portable format is still limited by discontinuous measurements, high cost, or designs not fit for portability. This work revolves around the development of a miniaturized potentiostat that can implement EIS to better accommodate the need for miniaturized sensing platforms. My design uses the AD5941 IC which is a single-chip potentiostat analog-front-end enabling a small form-factor that fits in the palm of the user’s hand. The device was able to characterize a resistor-capacitor circuit with errors as low as 0.052% and quantify the concentration of a redox active compound with a 6.2% error, providing agreeable results with a commercial benchtop potentiostat and demonstrating our device’s potential for diagnostic applications. Our working frequency range of 200 kHz – 0.15 Hz, coupled with high system configurability and a cost of $50 makes our device an accessible option for at-home and portable applications. Future work to implement truly wireless functionalities, such as WiFi or Bluetooth Low Energy, along with experimental testing of biological substances will create a truly robust platform for portable diagnostic and sensing applications.