[cid:image003.jpg@01D9FAB9.71DE0610] BME WEEKLY ROUNDTABLE WEEK OF October 9, 2023 OCTOBERBREAK! INTERIM HEAD'S NOTE To everyone, please enjoy your Octoberbreak. We have finally gotten some autumn weather. Fall has always been my favorite season. The time when everything bursts with its last beauty as if nature had been saving up year for the grand finale. Did you go to the Feast of the Hunters' Moon? If you did, I hope you enjoyed some time off with family and friends. Sweater weather is better together. We are now getting together to go through the thick of the semester which has been crazy so far with the many events and activities in September. Now we are getting together to show our presence at BMES later this week. I want to send my special thanks to Vitaliy, Cindy, and Asem who have worked hard to get everything ready. Thanks in advance to Cindy, Sandy, Tammy, Asem, Darshini, Luke, and Siting for setting up our booth and staying at our booth during the reception on Wednesday. If you plan to attend the Reception on Wednesday, please stop by our booth during the reception (BMES Booth 800). Thank you for all of you who will serve at our booth during the conference. Travel safely, everyone. UPCOMING IMPORTANT DATES Week of October 9 Mon., Oct. 9 - Tues., Oct. 10: Our semi-annual air handling shutdown is tentatively scheduled for Tuesday, October 10th. As a reminder: the entire building air handling system in MJIS will be turned off. ALL chemical hood activity, biosafety cabinet activity, autoclave work and activities in wet labs will need to STOP by 5 PM on Monday, October 9th. Any chemicals stored in the hoods will have to be sealed at that time. Signs will be posted on all hoods to remind users not to use the hoods Monday evening, and removed when the maintenance work is completed and normal operations can resume. Please plan ahead - DO NOT use chemicals in the lab areas that you would normally use in the hoods. Mon., Oct. 9 - Tues., Oct. 10: The NSF I-Corps Hub Great Lakes is offering an Industry Connect Program<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.greatlakesicorps.org%2Fevent%2Findustry-connect-medical-devices-manufacturing-minneapolis%2F&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187298400%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=0lV7j7rrVdxv4N6G%2FQLMKqC59%2FzTyOKunlbTvqtA9C0%3D&reserved=0>, on Oct 9-Oct 10 in Minneapolis for attendees participating in the Medical Design and Manufacturing Conference, MD&M Conference<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.advancedmanufacturingminneapolis.com%2Fen%2Fshow-brands%2Fmdm-minneapolis.html&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187298400%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=jc%2BablLK1lX%2FZQVWA5PMy5JkJ04DCCuxpQmoLkbj1zk%3D&reserved=0>. The primary goal of the Industry Connect workshop is to provide teams with essential networking and customer discovery skills on how to introduce themselves, talk to technology decision-makers, set up follow-up meetings, acquire feedback, and identify key milestones, etc. Teams then participate in a tradeshow (MD&M Conference) to apply the skills they have acquired. The hub is also offering a Medical Jumpstart Workshop<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.greatlakesicorps.org%2Fevent%2Ffall-2023-medical-jumpstart-regional-i-corps-course%2F&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=l7g08lbaGbopiIbY792TFqnP5m6dXpgRgVXURz3Tm6M%3D&reserved=0>, Sept 29-Nov 17 (offered virtually) to teams exploring the commercial viability of their Medical-based innovation idea. This course is for faculty, researchers, and students with Medical-based ideas or Intellectual Property and a strong interest in commercializing their technology. Teams participating in this workshop will receive funding up to $1000/team for Customer Discovery purposes. The funding can also be used to participate in the Industry Connect Program. Please share this information with interested faculty and students. Feel free to reach out to me or Matthew Lynall (mlynall@purdue.edu<mailto:mlynall@purdue.edu>) for any questions. Thanks, Geetali Geetali Pradhan, Ph.D., MBA (gpradhan@purdue.edu<mailto:gpradhan@purdue.edu>) Tech Commercialization Specialist, Daniels School of Business Innovation and Outreach Specialist, NSF I-Corps Hub, Great Lakes Region Purdue University LinkedIn<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.linkedin.com%2Fin%2Fgeetali-pradhan-8971591a%2F&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=yVwIw2jSBE4xeuUc0sQTUjnYeMjFKxs6N%2BonjFWUp9E%3D&reserved=0> Google Scholar<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fscholar.google.com%2Fcitations%3Fuser%3DK5IZpcgAAAAJ%26hl%3Den%26oi%3Dao&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Mn%2FTQnI0sUhKObe3bhnCSRwzHv9%2BPE43oTnmVZU5Lm8%3D&reserved=0> Great Lakes I-Corps Hub Website<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.greatlakesicorps.org%2F&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=hbZz29ZD5fu%2FD8%2B5tm9ISmFC0Ys2QPfsSTqGtWoNI7w%3D&reserved=0> Mon., Oct. 9: Center for Diabetes and Metabolic Diseases Seminar, 12:00 noon, R4 101 (Indianapolis) and via Zoom. Guisheng Song, Associate Professor of Medicine, University of Minnesota, Twin Cities will present "Maximization of Genetic Information During the Development of MAFLD." Zoom link: https://iu.zoom.us/s/87501979533<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fiu.zoom.us%2Fs%2F87501979533&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=hFDdX2eaOIKEaV%2FvnOOugh8zYGcdPQflu7htM3b8EsY%3D&reserved=0> Wed., Oct. 11: BME Research Seminar, 9:30 a.m., MJIS 1001 and via Zoom. Kyung Sung, Chief of Cellular and Tissue Therapy Branch, Office of Cellular Therapy and Human Tissue, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, will present "Advanced analytical methods for Assessing the bioactivity of regenerative medicine cellular products." Wed., Oct. 11: BME PhD Preliminary Exam Announcement for Hao-Cheng Gao (F. Huang, advisor). Everyone is invited to attend the public presentation beginning at 2PM in MJIS 2001. Research title: Ultrahigh-Resolution Imaging and Quantitative Analysis Through Brain Tissue with High Accuracy. Thurs., Oct. 12: BME PhD Preliminary Exam Announcement for Donghyun Yim (T. Kim, advisor). Everyone is invited to attend the public presentation beginning at 12:00 pm in MJIS 2001. Title: Computational modeling of chemotactic cell migration enhanced with stress fiber dynamics. Thurs., Oct. 12: Seminars in Hearing Research, 12:00 noon. Kelsey L. Anbuhl, PhD, Postdoctoral Fellow in Sanes Laboratory, NYU, will present "A top-down, cingulate-to-auditory cortex projection facilitates effortful listening." This seminar will be by Zoom only. Zoom link: https://purdue-edu.zoom.us/j/4326340458<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F4326340458&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=nMsFo05WUgJBVs3lryypKgL9pEPaJ2ekQpDiZPsKicg%3D&reserved=0> Meeting ID: 4326340458 MJIS Updates Our semi-annual air handling shutdown is tentatively scheduled for Tuesday, October 10th. As a reminder: the entire building air handling system in MJIS will be turned off. ALL chemical hood activity, biosafety cabinet activity, autoclave work and activities in wet labs will need to STOP by 5 PM on Monday, October 9th. Any chemicals stored in the hoods will have to be sealed at that time. Signs will be posted on all hoods to remind users not to use the hoods Monday evening, and removed when the maintenance work is completed and normal operations can resume. Please plan ahead - DO NOT use chemicals in the lab areas that you would normally use in the hoods. Graduate Programs Update Are you interested in establishing and implementing your own approaches to teaching undergraduates? Are you looking for a meaningful teaching experience to put on your resume/CV? If so, please consider applying for the College of Engineering Dean's Teaching Fellowship! What: Be the Instructor for a Course in your School When: Two Semesters | Spring/Summer 2024 apprenticeship followed by Summer/Fall 2024 Instructorship Deadline: Applications are due by Wednesday, November 1st, 2023. Applicants must include an endorsement form from their School/Division (details in attached .pdf) and should allow time to secure this before the deadline! Apply here: https://purdue.ca1.qualtrics.com/jfe/form/SV_cCuy9sXBciXIiuW<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca1.qualtrics.com%2Fjfe%2Fform%2FSV_cCuy9sXBciXIiuW&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=JvTz7jDXrTTGVmuIF8v%2BGbJCgMKsNLvuwyR8uzhI%2BCE%3D&reserved=0> Details: * Scholarship of $5,000 split across two semesters (Spring, Summer, and/or Fall 2024) * Half-time TA for one semester (typically Fall 2024) * $750 for personal purchase of technology/equipment for the classroom, and more! Who: Eligibility is listed in the attached document. Must be a College of Engineering PhD student from a participating school (see attached). Must be perceived by the student's advisory committee chair as having high potential to be successful in academia. Please note: Your School may have its own specific Teaching Fellowship with a similar deadline, and the College Dean's Teaching Fellowship cannot be awarded in the same year to a graduate student who has received a Teaching Fellowship through their own School. Please see the attached announcement for additional details. The goal of this College of Engineering Dean's Teaching Fellowship is to provide additional opportunities for you to teach during your senior graduate school years, which can also be excellent training for graduate students planning to pursue faculty careers. The 2024 Dean's Teaching Fellows will be selected by the College of Engineering's review committee, and applicants will be notified by December 15, 2023. We highly encourage students from all backgrounds to apply for this opportunity. Please let me know what questions you have! Stephen M. McBride, Ph.D. Assistant Director, Graduate Student Success College of Engineering - Graduate Education Purdue University Neil Armstrong Hall of Engineering ARMS 1233 701 West Stadium Avenue West Lafayette, IN 47907 mcbrid44@purdue.edu<mailto:mcbrid44@purdue.edu> www.engr.purdue.edu/grad<http://www.engr.purdue.edu/grad> Upcoming important deadlines and information Wed., Oct. 18: Seminar for Neurotrauma and Diseases, 4:00 p.m., NLSN 1995. Richard Rogers, MD, Neurosurgeon, Goodman Campbell Brain and Spine Neurosurgery Group will present "Traumatic Brain Injury Outcome Prediction from the ICU." This seminar series is organized by the Center for Paralysis Research and supported by Plexon, the Purdue Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. The Zoom link is: https://bit.ly/441Dllq<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbit.ly%2F441Dllq&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=6GTx9lIAsNO%2FB5Z3fkLBHHZiESakp8VsuliTZt9M8Jo%3D&reserved=0>. For additional information, see https://vet.purdue.edu/cpr/ Wed., Oct. 25: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131. Wenjing Sun, Assistant Professor of Neuroscience, The Ohio State University will present "Unraveling the Cellular and Molecular Mechanisms Controlling Activity-dependent Myelin Formation and Restoration in the Central Nervous System." This seminar series is organized by the Center for Paralysis Research and supported by Plexon, the Purdue Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. The Zoom link is: https://bit.ly/441Dllq<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbit.ly%2F441Dllq&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=6GTx9lIAsNO%2FB5Z3fkLBHHZiESakp8VsuliTZt9M8Jo%3D&reserved=0>. For additional information, see https://vet.purdue.edu/cpr/ Wed., Nov. 29: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131. Koji Uchida, Professor of Food Chemistry, University of Tokyo will present "Conversion of Proteins into DNA Mimetics by Reactive Aldehydes." This seminar series is organized by the Center for Paralysis Research and supported by Plexon, the Purdue Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. The Zoom link is: https://bit.ly/441Dllq<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbit.ly%2F441Dllq&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=6GTx9lIAsNO%2FB5Z3fkLBHHZiESakp8VsuliTZt9M8Jo%3D&reserved=0>. For additional information, see https://vet.purdue.edu/cpr/ Fri., Dec. 1: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Jackie Linnes, Associate Professor of Biomedical Engineering at Purdue. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Fri., March 1: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Andrew Miller, Associate Professor and Chair, Department of Hunan-Centered Computing, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Fri., June 7: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor, Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Resources and further information Wed., Oct. 11: BME Research Seminar, 9:30 a.m., MJIS 1001 and via Zoom. Kyung Sung, Chief of Cellular and Tissue Therapy Branch, Office of Cellular Therapy and Human Tissue, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, will present "Advanced analytical methods for Assessing the bioactivity of regenerative medicine cellular products." Abstract: Multipotent stromal cells (MSCs) have become popular sources for manufacturing regenerative medicine cellular products due to their ability to undergo lineage-specific differentiation. MSCs, on the other hand, are heterogeneous and responsive to their surroundings, resulting in distinct subpopulations of cells with potentially different properties required for product functional bioactivity. Because there are numerous biochemical and biomechanical factors that influence MSC function, developing reliable high-throughput assays that allow for the efficient exploration of large and complex parameters for evaluating cellular function is critical. Microphysiological systems offer a viable solution to this unmet need. This presentation will provide an overview of regenerative medicine cellular product regulation as well as easy-to-use, microscale technologies that improve throughput, relevance, and reliability. How such technologies could be used to evaluate the efficacy of regenerative medicine cellular products will also be discussed. Biography: Dr. Kyung Sung is the Chief of the Cellular and Tissue Therapies Branch in the Office of Cellular Therapy and Human Tissue at the Center for Biologics Evaluation and Research, U.S. Food and Drug Administration. In addition to overseeing regulatory science research programs, she is responsible for overseeing the regulatory review process for cell and tissue therapeutic products and medical devices. Her research team studies the effects of interactions between living cells and biomaterials by developing novel quantitative assays using a variety of biomedical engineering tools. The overarching goal is to understand how these interactions affect the production and characterization of regenerative medicine cellular products. She earned her Ph.D. in Chemical Engineering from the University of Michigan, Ann Arbor, and completed her postdoctoral training at the University of Wisconsin, Madison. Before joining the FDA in 2015, she had experience working as a patent examiner in Biotechnology at the US Patent and Trademark Office. ~ BME Host: Young Kim ~ Zoom link: https://purdue-edu.zoom.us/j/5593290378?pwd=eFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F5593290378%3Fpwd%3DeFBOZFlNTU50ZDA2S2gwcnpyOWIwUT09&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=pJu2ZMXZDAT0ZYY0hL8DLXuTUaEcHGOmnfX0Fg7sVds%3D&reserved=0> Note: Students registered for the seminar are expected to attend in-person. Wed., Oct. 11: BME PhD Preliminary Exam Announcement for Hao-Cheng Gao (F. Huang, advisor). Everyone is invited to attend the public presentation beginning at 2PM in MJIS 2001. Research title: Ultrahigh-Resolution Imaging and Quantitative Analysis Through Brain Tissue with High Accuracy. Thesis Committee members: Fang Huang, Chair; Alexander A. Chubykin; Daniel M. Suter; Kevin J. Webb Abstract: 4Pi single-molecule localization microscopy (4Pi-SMLM) enables the revealing of ultrastructure by combining interferometric coherent fluorescence imaging and single-molecule localization. Current methods model the interferometric point spread function (PSF) by scanning in-vitro beads on coverslips to infer in-situ 3D location of single-molecule fluorophores in specimens. Although a resolution of sub-20-nm throughout the whole cell has been achieved, imaging tissue specimens was impeded by the heterogeneous aberration and scattering in tissue environment. Here, we introduce 4Pi in-situ PSF retrieval method (4Pi-INSPR), which allows 12-nm-resolution visualization and quantitative analysis through brain tissue with high accuracy. 4Pi-INSPR incorporates sample-induced aberrations, previously unattainable by conventional 4Pi-SMLM. 4Pi-INSPR also minimizes reconstruction artifacts from instrumental imperfections such as objective and imaging-quadrant misalignments. We demonstrate 4Pi-INSPR capabilities by revealing the ultrastructure of dendrites and dendritic spines in 50-μm mouse brain sections and quantifying their morphology changes and nanoscale molecular distribution. Together, 4Pi-INSPR provides potential in examining synaptic functions for brain development. Thurs., Oct. 12: BME PhD Preliminary Exam Announcement for Donghyun Yim (T. Kim, advisor). Everyone is invited to attend the public presentation beginning at 12:00 pm in MJIS 2001. Title: Computational modeling of chemotactic cell migration enhanced with stress fiber dynamics. Advisory Committee: Taeyoon Kim, Chair; Adrian Buganza-Tepole; Daniel M. Suter; Qing Deng Abstract: Directional cell migration is the essential ability of many cells and occurs in the guidance of different types of cues, including substrate stiffness, surface topology, and chemoattractant gradient. In particular, when the external chemotactic stimuli are present, chemoattractant successively activates signaling pathways in the cell, followed by the nucleation and polymerization of actin filaments (F-actins). As a result, F-actin establishment and protrusion are biased at the sites with the maximal concentration of chemotactic cues, leading to migration toward chemoattractant. For the migration, formation of focal adhesions between the cell and an extracellular environment is necessary. Chemotaxis has been studied in various computational studies. However, to our knowledge, the computational model of chemotaxis considering the dynamics of F-actins and focal adhesions still lacks. To address this gap, we introduce a two-dimensional cell migration model comprising nucleus, membrane, F-actins, and underlying substrate. In this model, it is assumed that the elongation rate of an individual F-actin is enhanced by the local chemoattractant level in order to capture the dependence of the F-actin polymerization rate on the chemoattractant concentration. Repulsive forces act between F-actin and the membrane to simulate the membrane protrusion driven by elongating F-actins. F-actins are allowed to bind to substrate via focal adhesions. In preliminary results, it was observed that a cell located in the middle of a linear concentration gradient for chemoattractant protrudes and then migrates toward the region with higher concentration. We expect the current concept of the model will provide better understanding of F-actin-mediated chemotaxis. BME Weekly Research Seminars Week # Date Speaker Title Host Website 8 10/11/2023 Kyung Sung Chief of Cellular and Tissue Therapy Branch, FDA Young Kim https://www.fda.gov/vaccines-blood-biologics/biologics-research-projects/investigating-effects-cell-materials-interactions-safety-and-effectiveness-cell-based-products<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.fda.gov%2Fvaccines-blood-biologics%2Fbiologics-research-projects%2Finvestigating-effects-cell-materials-interactions-safety-and-effectiveness-cell-based-products&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=c5H9p82A25mqLW1K7T9%2Bs7CqTPU%2BSiepBd3yZ1mnIfE%3D&reserved=0> 9 10/18/2023 Alan Grodzinsky Professor of Biological, Electrical, and Mechanical Engineering Department of Biological Engineering, MIT Deva Chan https://be.mit.edu/directory/alan-j-grodzinsky<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbe.mit.edu%2Fdirectory%2Falan-j-grodzinsky&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187454665%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=dh%2Fpmg%2BWLRG6wXAbusW8lN0v73e2K9mnJXroSA4mZrU%3D&reserved=0> 10 10/25/2023 Nian Wang Assistant Professor of Radiology & Imaging Sciences, Indiana School of Medicine Yunjie Tong https://medicine.iu.edu/faculty/48212/wang-nian<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmedicine.iu.edu%2Ffaculty%2F48212%2Fwang-nian&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187610953%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Y77HmcZEZUJgRjMGFBNU5XVrJZXgavbYxiQ9AOq4cP0%3D&reserved=0> 11 11/1/2023 Ben Gaston Billie Lou Wood Professor of Pediatrics Indiana University School of Medicine George Wodicka https://medicine.iu.edu/faculty/43800/gaston-benjamin<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmedicine.iu.edu%2Ffaculty%2F43800%2Fgaston-benjamin&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187610953%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=mDvN0FlUydkj5ND%2BvOf0FZyKF8U92vMyFNP3YO447I8%3D&reserved=0> 12 11/8/2023 Jean-Pierre Mobasser Affiliate Clinical Faculty Indiana University Young Kim https://www.goodmancampbell.com/our-team/team-member/jean-pierre-mobasser-md<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.goodmancampbell.com%2Four-team%2Fteam-member%2Fjean-pierre-mobasser-md&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187610953%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=UdpUVm%2BaIw7iP%2FIOivIFDbwaxuln23ambhMp5kSvZHk%3D&reserved=0> 13 11/15/2023 Jane Grande- Allen Isabel C. Cameron Professor of Bioengineering, Rice University Deva Chan https://profiles.rice.edu/faculty/k-jane-grande-allen<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fprofiles.rice.edu%2Ffaculty%2Fk-jane-grande-allen&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187610953%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=coCME%2BMU%2BWGA%2FkuV5kVYhWFasgvc0%2BMv8i7wfs87ZVI%3D&reserved=0> 14 11/29/2023 Sarah Wiehe Jean and Jerry Bepko Professor of Pediatrics Indiana University School of Medicine George Wodicka https://medicine.iu.edu/faculty/16722/wiehe-sarah<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmedicine.iu.edu%2Ffaculty%2F16722%2Fwiehe-sarah&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187610953%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=%2BYn%2FaLAnsRHQsFq6qKvql%2F6I6KH9qJgqiyPZkqrl2ug%3D&reserved=0> 15 12/6/2023 Robbee Wedow Assistant Professor of Sociology and Data Science, Purdue University Department of Sociology David Umulis https://www.robbeewedow.com/?_ga=2.88497945.389094989.1679581193-1816225309.1603576015<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.robbeewedow.com%2F%3F_ga%3D2.88497945.389094989.1679581193-1816225309.1603576015&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187610953%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=6cXhRJp7ipP4FzKIhRr0WQcDg6HHHC6DInX9DT8HDcs%3D&reserved=0> Postdoctoral Fellow Opportunity - IUSM Emergency Medicine The laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include: (1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally. For additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Findiana.peopleadmin.com%2Fpostings%2F19651&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C0db8652b2d94403b439f08dbc8f21c49%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638324715187610953%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=6yfZSB0jRiAQLhpyJISmsJhonUOk%2FiCa%2FTCD9jXwSQ4%3D&reserved=0> Attachments 2024 College of Engineering Dean's Teaching Fellowship -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list
