[cid:image001.jpg@01DA026C.420AF9B0] BME WEEKLY ROUNDTABLE WEEK OF October 16, 2023 INTERIM HEAD'S NOTE Dear all, sorry for the delay. After I came back from the BMES annual conference. I flew to another conference on Saturday afternoon. I have just returned to Indianapolis. * Many of us had a wonderful experience at the BMES annual conference. It was so good to see our faculty, staff, and students. It was so good to meet our alumni and old colleagues at the conference, and particularly, at the school reception. I took one picture when helping set up the booth. Our staff worked tirelessly at the conference, at the booth, and at the reception. I want to send my special thanks to them. The picture is below. * [cid:image002.jpg@01DA026D.95455250] * I went to the Councils of Chairs meeting at the BMES. Here is a short summary about the agenda: 1) the summary of a BME departments survey and 2) an update on AHPA-H. Let me know if you want a more detailed update. I clearly see the excitement among the BME research community on the upcoming AHPA-H opportunities. Some of us may have gotten included onto these large teams. Please let me know how the department can help. The IUPUI integration is going well. * I am pleased to inform you that Dr. Rachel Surowiec has decided to join the Weldon School of Biomedical Engineering as an Assistant Professor with a tenure-track appointment. She told me that she is enthusiastic about joining the School, and look forward to collaborating with our faculty and students, supporting the School's objectives, continuing to engage in mentoring and teaching, and having a long and productive research career at Purdue. * I am also pleased to inform you (some of you may have known) that Dr. Sharon Miller, already one of us as a non-tenure faculty member in our school, has accepted the position of Assistant Vice Provost for Purdue University in Indianapolis. That being said, she will continue teaching in Indianapolis this semester and co-teach second semester capstone in spring 2024. She, as well as Dr. Steve Higbee and others, have helped us work out our suggestions and proposals on academic programs for Purdue University - Indy. The Purdue Life and Health Sciences Summit will take place today, Oct. 19, from 1-5 p.m. in the Burton D. Morgan Center for Entrepreneurship, Room 121. The 6 finalists were announced in Purdue Today a couple days ago. * Unlocking a Blueprint for Health: The Endoplasmic Reticulum (ER) as a Disease Safeguard * Leveraging Cross-species Digital Twins for Modeling Cancer Progression and Outcome * Synaptic Ultra-Structure and Disease (SUSD) * Using Across-phyla Methods to Increase Genomic Prediction Accuracy to Improve Health and Food Security * Data-Driven Cross-Species Auditory Neuroscience for Accessible Mechanistic Precision Audiology * Role of Environmental Contaminant Exposure in the Health Inequities of Alzheimer's Disease-Related Dementias (ADRD) in Rural Populations Regarding your current involvement, it is still interesting to attend the summit to learn about these finalist teams. UPCOMING IMPORTANT DATES Week of October 16 Mon., Oct. 16: Center for Diabetes and Metabolic Diseases Research Seminar, 12:00 noon, R4-101 (Indianapolis) and via Zoom. Danielle Janosevic, D.O., M.S., Assistant Professor of Medicine IUSM and Thomas De Luca, PhD, Assistant Scientist in Medicine, IUSM will co-present "Acute Kidney Injury in Diabetes: The Role of Phingolipids." Zoom link: https://iu.zoom.us/j/87501979533<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fiu.zoom.us%2Fj%2F87501979533&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=loTfMsyHnAntr0V8TitgzAe5BNBKI62tWFd1SrNqOW0%3D&reserved=0> Tues., Oct. 17: Environmental and Ecological Engineering Research Seminar, 10:30 a.m., POTR 234 (Fu Room). Nikola M. Juhasz, PhD, Global Technical Director for Sustainability, Sun Chemical Corporation, will present "The Urgent Journey to Circularity and Sustainability." Wed., Oct. 18: BME Research Seminar Series, 9:30 a.m., MJIS 1001 or via Zoom. Alan Grodzinsky, PhD, Departments of Biological, Electrical and Mechanical Engineering, Center for Biomedical Engineering, MIT, will present "Human Osteochondral-Synovium Co-Culture Model of Cartilage Degradation & Therapeutic Intervention: Relevance to Post-Traumatic OA on Earth and in Space." Wed., Oct. 18: Advancing Discovery in Antimicrobial Resistance Seminar, 12:00 p.m., Purdue DRUG, Lobby Conference Room. Dr. Christina Ferreira, Bindley Bioscience Center and Center for Analytical Instrumentation and Development (CAID) at Purdue will present "Fat Matters for Microbes and for Purdue: How the role of Lipids in Infectious Disease and Antibiotics Resistance can be Explored using Shared-User Analytical Platforms Available on Campus." These seminars are supported by Purdue's College of Veterinary Medicine, Department of Basic Medical Sciences and Institute for Drug Discovery. Wed., Oct. 18: Seminar for Neurotrauma and Diseases, 4:00 p.m., NLSN 1995. Richard Rogers, MD, Neurosurgeon, Goodman Campbell Brain and Spine Neurosurgery Group will present "Civilian Gunshot Wounds and Neurotrauma." This seminar series is organized by the Center for Paralysis Research and supported by Plexon, the Purdue Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. The Zoom link is: https://bit.ly/441Dllq<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbit.ly%2F441Dllq&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=gdR15Xj%2BG%2B4CRjVx4Ril5dAZ8TAzvCabnEQI%2FDyO%2FVQ%3D&reserved=0>. For additional information, see https://vet.purdue.edu/cpr/ Thurs., Oct. 19: Purdue Distinguished Ambassador Lecture and Krach Freedom Lecture, 10:30 a.m., Union Club Hotel North Ballroom. Join us for a conversation with Nate Fick, the inaugural U.S. Ambassador at Large for Cyberspace and Digital Policy. Moderated by former U.S. Under Secretary of State Keith Krach. RSVP: https://tinyurl.com/kitdpfick<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Ftinyurl.com%2Fkitdpfick&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=t9rIaEj0eSesfqUpkDCqfTVzJIRbRi5TEJKXv5uoaIA%3D&reserved=0> There will be networking and a light breakfast at 10:00 a.m. Sponsored by the Krach Institute for Tech Diplomacy at Purdue. Thurs., Oct. 19: Seminars in Hearing Research, 12:00 p.m. via Zoom. Aditi Gargeshwari, Doctoral Candidate, Auditory Electrophysiology Lab, SLHS will present "Influence of Visual Speech Cues on Auditory Subcortical and Cortical Responses in Normal and Impaired Ears." This seminar will be offered virtually only. Zoom link: https://purdue-edu.zoom.us/j/4326340458<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F4326340458&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=D8Q1Jjf%2FccxE0D5%2BScKYFIHUCYgXH7iL83ifgMxmdAo%3D&reserved=0> . These seminars are sponsored by Speech, Language and Hearing Sciences. Thurs., Oct. 19: Purdue Engineering Distinguished Lecture Series: Al Bovik, The Cockrell Family Regents Endowed Chair, Professor and Director of the Laboratory for Image and Video Engineering, University of Texas at Austin, will present "Secret of Video Quality" at 2:00 p.m. in the ARMS Atrium. Register here: https://purdue.ca1.qualtrics.com/jfe/form/SV_6EetsE7oLoMwg9E?utm_source=delivra&utm_medium=email&utm_campaign=PEDLS%20-%20Al%20Bovik%20-%20Oct%202023&utm_id=45368744<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca1.qualtrics.com%2Fjfe%2Fform%2FSV_6EetsE7oLoMwg9E%3Futm_source%3Ddelivra%26utm_medium%3Demail%26utm_campaign%3DPEDLS%2520-%2520Al%2520Bovik%2520-%2520Oct%25202023%26utm_id%3D45368744&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=5EAeseCg4iKYeoj4BV94i5ir0P%2FHSw8kVD136AfHQiY%3D&reserved=0> Thurs., Oct. 19: College of Veterinary Medicine Graduate Seminar Series, 12:30 p.m., LYNN 1136. Four graduate students/staff will present: Em Adam, Resident, CPB will present "Low Numbers of Heinz Bodies in Cats: Normal Finding or Subclinical Damage." Annapoorani Jegatheesan, Graduate RA, CPB will present "Characterization of SnROP9, a Rhoptry Protein of Sarcocystis Neurona." Martina Dalolio, IBSC Graduate Student will present "An Enhanced Mice Model of Post-Traumatic Epilepsy to Study Epileptogenesis nd Identify Electroencephalographic Biomarkers." Ying Chen Chen, Graduate RA, BMS will present "Adipose Derived Mesenchyml Stromal Cells as Oncolytic Adenovirus Carriers to Treat Prostate Cancer." The seminars are sponsored by the College of Veterinary Medicine. Graduate Programs Update Are you interested in establishing and implementing your own approaches to teaching undergraduates? Are you looking for a meaningful teaching experience to put on your resume/CV? If so, please consider applying for the College of Engineering Dean's Teaching Fellowship! What: Be the Instructor for a Course in your School When: Two Semesters | Spring/Summer 2024 apprenticeship followed by Summer/Fall 2024 Instructorship Deadline: Applications are due by Wednesday, November 1st, 2023. Applicants must include an endorsement form from their School/Division (details in attached .pdf) and should allow time to secure this before the deadline! Apply here: https://purdue.ca1.qualtrics.com/jfe/form/SV_cCuy9sXBciXIiuW<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca1.qualtrics.com%2Fjfe%2Fform%2FSV_cCuy9sXBciXIiuW&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=VC44RJjYZvv%2BFWoWtQHYol8HhPNt77L7%2BQ921CEkbpk%3D&reserved=0> Details: * Scholarship of $5,000 split across two semesters (Spring, Summer, and/or Fall 2024) * Half-time TA for one semester (typically Fall 2024) * $750 for personal purchase of technology/equipment for the classroom, and more! Who: Eligibility is listed in the attached document. Must be a College of Engineering PhD student from a participating school (see attached). Must be perceived by the student's advisory committee chair as having high potential to be successful in academia. Please note: Your School may have its own specific Teaching Fellowship with a similar deadline, and the College Dean's Teaching Fellowship cannot be awarded in the same year to a graduate student who has received a Teaching Fellowship through their own School. Please see the attached announcement for additional details. The goal of this College of Engineering Dean's Teaching Fellowship is to provide additional opportunities for you to teach during your senior graduate school years, which can also be excellent training for graduate students planning to pursue faculty careers. The 2024 Dean's Teaching Fellows will be selected by the College of Engineering's review committee, and applicants will be notified by December 15, 2023. We highly encourage students from all backgrounds to apply for this opportunity. Please let me know what questions you have! Stephen M. McBride, Ph.D. Assistant Director, Graduate Student Success College of Engineering - Graduate Education Purdue University Neil Armstrong Hall of Engineering ARMS 1233 701 West Stadium Avenue West Lafayette, IN 47907 mcbrid44@purdue.edu<mailto:mcbrid44@purdue.edu> www.engr.purdue.edu/grad<http://www.engr.purdue.edu/grad> Upcoming important deadlines and information Wed., Oct. 25: BME Research Seminar: 9:30 a.m., MJIS 1001 and via Zoom. Kennedy O. Okeyo, PhD, TIS/Project Manager, Jackson Laboratory Japan will present "Microengineering Approaches for Biofunction Design in the Era of Personalized Medicine." Wed., Oct. 25: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131. Wenjing Sun, Assistant Professor of Neuroscience, The Ohio State University will present "Unraveling the Cellular and Molecular Mechanisms Controlling Activity-dependent Myelin Formation and Restoration in the Central Nervous System." This seminar series is organized by the Center for Paralysis Research and supported by Plexon, the Purdue Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. The Zoom link is: https://bit.ly/441Dllq<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbit.ly%2F441Dllq&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=gdR15Xj%2BG%2B4CRjVx4Ril5dAZ8TAzvCabnEQI%2FDyO%2FVQ%3D&reserved=0>. For additional information, see https://vet.purdue.edu/cpr/ Wed., Oct. 25: Advancing Discovery in Antimicrobial Resistance Seminar, 12:00 p.m., Purdue DRUG, Lobby Conference Room. Dr. Daniel P. Flaherty, Associate Professor of Medicinal Chemistry and Molecular Pharmacology and PI4D-PIIN-PICR-PIDD at Purdue will present "Evaluation of bacterial carbonic anhydrases as antibiotic therapeutic targets." These seminars are supported by Purdue's College of Veterinary Medicine, Department of Basic Medical Sciences and Institute for Drug Discovery. Wed., Nov. 29: Seminar for Neurotrauma and Diseases, 4:00 p.m., DLR 131. Koji Uchida, Professor of Food Chemistry, University of Tokyo will present "Conversion of Proteins into DNA Mimetics by Reactive Aldehydes." This seminar series is organized by the Center for Paralysis Research and supported by Plexon, the Purdue Institute for Integrative Neuroscience, and Purdue Institute for Drug Discovery. The Zoom link is: https://bit.ly/441Dllq<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbit.ly%2F441Dllq&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=gdR15Xj%2BG%2B4CRjVx4Ril5dAZ8TAzvCabnEQI%2FDyO%2FVQ%3D&reserved=0>. For additional information, see https://vet.purdue.edu/cpr/ Fri., Dec. 1: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Jackie Linnes, Associate Professor of Biomedical Engineering at Purdue. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Fri., March 1: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Andrew Miller, Associate Professor and Chair, Department of Hunan-Centered Computing, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Fri., June 7: Indiana Human-Centered Design for Health Seminar Series, 12:00 p.m. via Zoom. Lean about research and best practices in HCD and health, promote the diverse HCD expertise in Indiana, and build a community of HCD researchers and practitioners focused on health, in Indiana and beyond. The speaker will be Youngbok Hon, Professor, Herron School of Art and Design, IUPUI. Register and learn about upcoming seminars at healthtechquitylab.org/hcd-seminar Resources and further information Tues., Oct. 17: Environmental and Ecological Engineering Research Seminar, 10:30 a.m., POTR 234 (Fu Room). Nikola M. Juhasz, PhD, Global Technical Director for Sustainability, Sun Chemical Corporation, will present "The Urgent Journey to Circularity and Sustainability." Abstract: Achieving a Circular and Sustainable Economy is increasingly urgent to minimize and mitigate devastating effects on the planet associated with continuing business as usual. According to the Ellen MacArthur Foundation, which popularized the concept, a Circular Economy is one that designs out waste and pollution, that keeps products and materials in use, and that regenerates natural systems. These principles apply in the context of manufactured products, as well as to the processes and operations behind those products. This presentation will consider various programs, tools and initiatives helping minimize environmental impact and delivering circular and sustainable products and manufacturing within Sun Chemical, the global leader for pigments, inks, coatings, and advanced materials. A particular focus will be on circular packaging applications that are enabled by Sun Chemical's technologies. Bio: Dr. Nikola Juhasz is the Global Technical Director for Sustainability at Sun Chemical, where she engages with internal and external stakeholders to formulate sustainability-driven technical strategies and oversees the corresponding innovation and product development programs across all of Sun Chemical's pigments, inks, coatings, and adhesives product lines and technology platforms. She represents Sun Chemical at key global cross-industry organizations focused on sustainability and the future of packaging, including the Sustainable Packaging Coalition (SPC), and the Association of Plastic Recyclers (APR), among others. Dr. Juhasz joined Sun Chemical in 2018 as Global Director, Liquid Ink Technology. In this role she evolved the packaging ink applications and new product development portfolio to encompass numerous sustainability initiatives. Prior to joining Sun Chemical, Dr. Juhasz spent over 20 years in various positions of R&D leadership in the diversified chemicals, polymers, and materials industry. She holds a PhD in Chemical Engineering from the Massachusetts Institute of Technology, and a BS in Chemical Engineering from Purdue University. Wed., Oct. 18: BME Research Seminar Series, 9:30 a.m., MJIS 1001 or via Zoom. Alan Grodzinsky, PhD, Departments of Biological, Electrical and Mechanical Engineering, Center for Biomedical Engineering, MIT, will present "Human Osteochondral-Synovium Co-Culture Model of Cartilage Degradation & Therapeutic Intervention: Relevance to Post-Traumatic OA on Earth and in Space." Abstract: We established a human osteochondral-synovium microphysiological system incorporating a single impact mechanical load that emulates initial pathways and biomarker-release of post-traumatic osteoarthritis-like disease; we tested the effects of anti-catabolic dexamethasone and pro-anabolic IGF-1 to ameliorate PTOA-like processes. In addition, we tested the effects of microgravity and radiation ± drugs on this system on the International Space Station. Overall, 88 human distal femurs (Collins Grade 0-2) from 55 donors (M/F age 23-83) were obtained. We quantified release of inflammatory cytokines, cell viability, release of sGAG and ARGS-aggrecan and CTX-II collagen fragments, metabolomics/proteomics assays, and the response to Dex and IGF-1. Two Grade-0 knee-tissues were launched to the ISS on SpaceX-21 for 3-week experiments (M/31, F/47). Analyses showed release of inflammatory cytokines, mainly from synovium, on Earth and in Space, causing increases in release of sGAG and ARGS-aggrecan fragments, the earliest biomarkers of disease by 2-weeks in culture. Metabolites and peptide markers of inflammation were also increased. While Dex+IGF-1 decreased the release of sGAG and ARGS-aggrecan over-all, there was distinct donor-to-donor variability. Metabolomics showed increased oxidative stress and inflammation under spaceflight conditions; Dex+IGF-1 substantially reduced GAG release from one donor system in Space, but the second donor showed less response. Ongoing proteomic analyses focus on extent and kinetics of biomarker release, to aid in the timing and choice of therapeutics. Despite the increasing number and complexity of ongoing clinical trials for OA/PTOA therapeutics, the discovery and choice of drug(s) is only half the battle: the other half is delivery of drug(s) to the intended target(s). Most trials for knee OA/PTOA now involve intra-articularly injected drugs, but there is little or no evidence that injected drugs have reached their target tissues in the dose and duration needed. Does failure of such trials mean that drugs were not efficacious, or that potentially efficacious drugs never reached their intended target at the proper dose/duration due to drug delivery inadequacies? Biography: Alan Grodzinsky, ScD, is Professor Emeritus of Biological, Electrical, and Mechanical Engineering in the Departments of Biological Engineering (BE), Electrical Engineering and Computer Science, and Mechanical Engineering at MIT. His research interests center on osteoarthritis and degenerative joint disease; complex microphysiological organ-on-a-chip systems for drug discovery and drug delivery for osteoarthritis; tissue engineering for cartilage repair; cellular mechanotransduction; and molecular, cellular and tissue nanomechanics. He has published over 350 refereed journal articles and reviews in these fields. While his undergraduate and graduate training at MIT was originally in Electrical Engineering and Computer Science, he is a founding faculty member of MIT's Biological Engineering Department. At MIT, he developed two required graduate courses in BE Department and published a textbook on these subjects (Fields, Forces and Flows in Biological Systems, Garland Science, 2011) focusing on transport and biomechanical properties of connective tissues such as cartilage, skin, tendons and ligaments. He has received numerous awards including the NIH MERIT Award (for research on Cartilage Mechanobiology), the Melville Medal of the ASME, the Kappa Delta Prize of the AAOS, the Borelli Award of the Amer Soc of Biomechanics, the Outstanding Achievement in Mentoring Award of the Orthopaedic Research Society (ORS), the Distinguished Investigator Award of the ORS/AAOS, and the Lifetime Achievement Award of the Osteoarthritis Research Society International (OARSI). He was elected Founding Fellow of the American Institute of Medical and Biological Engineering, and is past Chair of the Gordon Research Conference on Musculoskeletal Biology and Bioengineering. He is past President of the ORS, the International Cartilage Repair Society (ICRS), and the Society for Physical Regulation in Biology and Medicine. He has consulted for numerous industrial and academic institutions, and USA federal agencies including the NIH, NASA, NSF, FDA, and the Department of Justice. ~ BME Host: Deva Chan ~ Zoom link: https://purdue-edu.zoom.us/j/95124789878?pwd=S0x0VW5Vd3VaMVc1LytlL0NJU1FYUT09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F95124789878%3Fpwd%3DS0x0VW5Vd3VaMVc1LytlL0NJU1FYUT09&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=QckuiNJD8rRLJKPMBC6C4CFs1HJL0WvsqGCVW8%2BmDEc%3D&reserved=0> NOTE: Students registered for the seminar are expected to attend in-person. Thurs., Oct. 19: Seminars in Hearing Research, 12:00 p.m. via Zoom. Aditi Gargeshwari, Doctoral Candidate, Auditory Electrophysiology Lab, SLHS will present "Influence of Visual Speech Cues on Auditory Subcortical and Cortical Responses in Normal and Impaired Ears." This seminar will be offered virtually only. Zoom link: https://purdue-edu.zoom.us/j/4326340458<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F4326340458&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=D8Q1Jjf%2FccxE0D5%2BScKYFIHUCYgXH7iL83ifgMxmdAo%3D&reserved=0> . These seminars are sponsored by Speech, Language and Hearing Sciences. Abstract The human brain can integrate information from different sensory modalities to produce a unified representation of the external world. Temporally congruent auditory and visual stimulation facilitates multisensory perception and integration, allowing us to better process and understand the information presented to us, especially in the presence of background noise and for individuals with hearing difficulties. The influences of visual speech cues on behavioral speech perception are vastly studied. Functional magnetic resonance imaging and electrophysiological studies have mostly evaluated auditory cortical responses. Little is known about the influence of visual speech production cues on the auditory brainstem phase-locked ensemble responses in normal and individuals with sensorineural hearing loss. To address this knowledge gap, we evaluated the effects of congruent- and incongruent-audiovisual (AV) speech on scalp-recorded brainstem frequency following response (FFR) and the cortical acoustic change complex (ACC). For the FFR, both phase locking to envelope periodicity (FFRENV) and to the temporal fine structure (FFRTFS) were evaluated. I will present our initial results showing that visual speech cues do influence evoked responses at both cortical and brainstem levels, albeit differently. These results appear to suggest that neural activity relevant to audio-visual integration may be already emerging at the brainstem level. Thus, these measures have the potential to be developed as clinical metrics for evaluation of audio-visual integration, and as measures to evaluate hearing-aid outcomes and prognosis. This year's SHRP schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fogww.mj.am%2Flnk%2FAU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo%2F5%2FVzPUtXKo0Dowllp_TK_BrQ%2FaHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX3NjaGVkdWxl&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=55X%2FZKf58QvcXtoDQ8Z7DxOkgSDYk3UovGUKbaIL904%3D&reserved=0> Titles and abstracts of all SHRP talks are here: https://purdue.edu/TPAN/hearing/shrp_abstracts<https://nam04.safelinks.protection.outlook.com/?url=http%3A%2F%2Fogww.mj.am%2Flnk%2FAU8AAEukm7AAAchk2HAAALFJlZgAAYCsFQMAnDnUAATD7ABh_T90ybQipdUVQZ20y9CAzjYFPgAEkSo%2F6%2Fa2vUEcd_J6SQbZdR8Ley5Q%2FaHR0cHM6Ly9wdXJkdWUuZWR1L1RQQU4vaGVhcmluZy9zaHJwX2Fic3RyYWN0cw&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=%2BZ0uhv%2Fjv2EhvAcjq%2BSVHGAwGjmKqDbjGXaZc9dYXxU%3D&reserved=0> Thurs., Oct. 19: Purdue Engineering Distinguished Lecture Series: Al Bovik, The Cockrell Family Regents Endowed Chair Professor and Director of the Laboratory for Image and Video Engineering, University of Texas at Austin, will present "Secret of Video Quality" at 2:00 p.m. in the ARMS Atrium. Register here: https://purdue.ca1.qualtrics.com/jfe/form/SV_6EetsE7oLoMwg9E?utm_source=delivra&utm_medium=email&utm_campaign=PEDLS%20-%20Al%20Bovik%20-%20Oct%202023&utm_id=45368744<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca1.qualtrics.com%2Fjfe%2Fform%2FSV_6EetsE7oLoMwg9E%3Futm_source%3Ddelivra%26utm_medium%3Demail%26utm_campaign%3DPEDLS%2520-%2520Al%2520Bovik%2520-%2520Oct%25202023%26utm_id%3D45368744&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852006150%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=5EAeseCg4iKYeoj4BV94i5ir0P%2FHSw8kVD136AfHQiY%3D&reserved=0> The lecture will be followed by a panel discussion at 3:30 p.m. "Does Image Analysis Have a Future in the Artificial Intelligence/Machine Learning World?" In this panel we will discuss where image analysis is headed in the brave new AI/ML world. Will we even need cameras when we can just "generate" whatever image we need? How does this impact hardware systems? What will students in the future who are interested in "imaging" need to know? The panel will be moderated by Edward Delp, Charles William Harrison Distinguished Professor of Electrical & Computer Engineering and Professor of Biomedical Engineering. Panelists include Qi Guo, Assistant Professor of Electrical and Computer Engineering, Fengqing Maggie Zhu, Associate Professor of Electrical and Computer Engineering, Greg Buzzard, Professor of Mathematics, and Melba M. Crawford, Nancy Uridil and Frank Bossu Distinguished Professor in Civil Engineering. For more information please go to the Purdue Engineering Distinguished Lecture Series web page: https://engineering.purdue.edu/Engr/AboutUs/News/Events/DistinguishedLecture... This seminar is hosted by the College of Engineering and the Elmore Family School of Electrical and Computer Engineering. Wed., Oct. 25: BME Research Seminar: 9:30 a.m., MJIS 1001 and via Zoom. Kennedy O. Okeyo, PhD, TIS/Project Manager, Jackson Laboratory Japan will present "Microengineering Approaches for Biofunction Design in the Era of Personalized Medicine." Abstract: We are witnessing the dawn of an era of personalized medicine, driven by technological advances in cell therapy, immunotherapy, and regenerative medicine. In this era, bioengineering capabilities that enable precise control and biofunction design, both at the cellular and tissue levels are increasingly becoming important, especially with regards to supporting patient-specific therapeutics and drug development. This talk will highlight our past and ongoing research efforts to develop enabling microengineering technologies for biofunction design at the cellular and tissue levels, and will showcase potential biomedical applications in cancer immunotherapy, regenerative medicine, and drug development. Biography: Dr. Okeyo is currently a technical information scientist (TIS) and a project manager at Jackson Laboratory Japan. He obtained his PhD degrees in mechanical engineering from Kyoto University, Japan, in 2010 and thereafter worked for two years as a researcher at the Central Research Laboratory of Hitachi Ltd, Japan. He then became an assistant professor at the Department of Mechanical Engineering of the university of Tokyo in Japan before moving to Kyoto University as a senior lecturer in charge of teaching and research supervision. Most recently he was a visiting scholar at Prof. Paul Robinson's lab affiliated with the Weldon School of Biomedical Engineering, Purdue University. ~ BME Host: Young Kim ~ NOTE: Students registered for the seminar are expected to attend in-person. Zoom link: https://purdue-edu.zoom.us/j/97556297644?pwd=SEJQOWMySnkzQWhGRlF4SW1XYjViZz09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F97556297644%3Fpwd%3DSEJQOWMySnkzQWhGRlF4SW1XYjViZz09&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852162419%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=VY0%2BqX%2FnD%2B6nWqN5vcyQ3Dl13qnJgWtpmmhPgkcdxH0%3D&reserved=0> BME Weekly Research Seminars Week # Date Speaker Title Host Website 9 10/18/2023 Alan Grodzinsky Professor of Biological, Electrical, and Mechanical Engineering Department of Biological Engineering, MIT Deva Chan https://be.mit.edu/directory/alan-j-grodzinsky<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbe.mit.edu%2Fdirectory%2Falan-j-grodzinsky&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852162419%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=bGF4oGqhP%2Bvk0eP5sncy87U1t70yV2eBAUmsE4kjTuU%3D&reserved=0> 10 10/25/2023 Kennedy Ikeyo TIS/Project Manager, Jackson Laboratory Japan Young Kim 11 11/1/2023 Ben Gaston Billie Lou Wood Professor of Pediatrics Indiana University School of Medicine George Wodicka https://medicine.iu.edu/faculty/43800/gaston-benjamin<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmedicine.iu.edu%2Ffaculty%2F43800%2Fgaston-benjamin&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852162419%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=FfObUwxnA2BvXRqYMpWFK3ol%2Fj1dhbfp462C%2FbDlnao%3D&reserved=0> 12 11/8/2023 Jean-Pierre Mobasser Affiliate Clinical Faculty Indiana University Young Kim https://www.goodmancampbell.com/our-team/team-member/jean-pierre-mobasser-md<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.goodmancampbell.com%2Four-team%2Fteam-member%2Fjean-pierre-mobasser-md&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852162419%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=A49nV1trOpebrNn%2FYaheS4J%2B2Z%2FXH653lyQLV1SYFdI%3D&reserved=0> 13 11/15/2023 Jane Grande- Allen Isabel C. Cameron Professor of Bioengineering, Rice University Deva Chan https://profiles.rice.edu/faculty/k-jane-grande-allen<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fprofiles.rice.edu%2Ffaculty%2Fk-jane-grande-allen&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852162419%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=zTu774ylXGKthVeEr6fLsu8y69nR2umJx5meXYDcV3M%3D&reserved=0> 14 11/29/2023 Sarah Wiehe Jean and Jerry Bepko Professor of Pediatrics Indiana University School of Medicine George Wodicka https://medicine.iu.edu/faculty/16722/wiehe-sarah<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmedicine.iu.edu%2Ffaculty%2F16722%2Fwiehe-sarah&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852162419%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Jjr%2BZmCcGTeNSwuPd%2FnkmoUKj77szUABajtOrRi6kdo%3D&reserved=0> 15 12/6/2023 Robbee Wedow Assistant Professor of Sociology and Data Science, Purdue University Department of Sociology David Umulis https://www.robbeewedow.com/?_ga=2.88497945.389094989.1679581193-1816225309.1603576015<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.robbeewedow.com%2F%3F_ga%3D2.88497945.389094989.1679581193-1816225309.1603576015&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852162419%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=SSkI1KIZ%2FMa6vLvruWuzsrhgIQ3lYYt7xl4JKhCz5jY%3D&reserved=0> Postdoctoral Fellow Opportunity - IUSM Emergency Medicine The laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include: (1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally. For additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Findiana.peopleadmin.com%2Fpostings%2F19651&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7Caa4fb053ba8c4c82501a08dbd0a66544%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638333185852162419%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=%2FLjOXTlXxnhvecvc6f8AwTmZ5%2BEO%2FZJdhcUJp9Z7bZk%3D&reserved=0> Attachments 2024 College of Engineering Dean's Teaching Fellowship -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list
