Dear EMBRIOphytes, Our All-Hands Seminar is today at 3pm ET on Zoom ( https://purdue-edu.zoom.us/j/99105530025?pwd=wPuFZtASboXSfD8Y9e4vsbKpcrKl5j.1&from=addon<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F99105530025%3Fpwd%3DwPuFZtASboXSfD8Y9e4vsbKpcrKl5j.1%26from%3Daddon&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C7429c4aa851b4f2e279408dcec451df4%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638645028798380509%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=9TobjM9lLX6mYwTB6nfX4dLqBOhGOcAXV1X%2FkICkSeo%3D&reserved=0> ): Title: Developing a multiscale understanding of energy-utilizing polymers Holly Goodson<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fchemistry.nd.edu%2Fpeople%2Fholly-goodson%2F&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C7429c4aa851b4f2e279408dcec451df4%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638645028798380509%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=jv2IO64k1UghXzATpIevp1K5cR9pNMs7Z3wJztR5lJM%3D&reserved=0>, Professor and Associate Chair [https://static.nd.edu/images/webclips/default/webclip-1024.png]<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fchemistry.nd.edu%2Fpeople%2Fholly-goodson%2F&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C7429c4aa851b4f2e279408dcec451df4%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638645028798380509%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=jv2IO64k1UghXzATpIevp1K5cR9pNMs7Z3wJztR5lJM%3D&reserved=0> Holly Goodson<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fchemistry.nd.edu%2Fpeople%2Fholly-goodson%2F&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C7429c4aa851b4f2e279408dcec451df4%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638645028798536734%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=tnaQeASLTxs2%2Ft%2B2CfTSauX1U4RWiuPlCmmL6wjPCFE%3D&reserved=0> Department of Chemistry and Biochemistry at the University of Notre Dame chemistry.nd.edu Department of Chemistry and Biochemistry Department of Biological Sciences University of Notre Dame Abstract: Microtubules are energy-utilizing polymers that serve as essential components of the eukaryotic cytoskeleton, enabling cells to divide, segregate their chromosomes, and organize themselves internally. Microtubule filaments display a puzzling behavior known as dynamic instability, in which they undergo distinct phases of growing and shortening, with approximately random transitions in between. Our lab and its collaborators integrate experiments, simulations and mathematical modeling to build a multi-scale and predictive understanding of microtubule dynamics. In this EMBRIO seminar, I will discuss our efforts to use machine-learning to objectively quantify and characterize MT dynamics, our application of this software to dissect the mechanism of a MT binding protein, and some “big picture” biological conclusions drawn from analysis of emergent population-level behaviors exhibited by our dimer-scale, agent-based simulations of microtubule assembly. Fall Semester Seminar Schedule: Sept 9 State of the Institute and open discussion Leadership Team members lead/present - include Institute eval results? Sept 23 Donny Hanjaya Putra https://dhplab.nd.edu/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdhplab.nd.edu%2F&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C7429c4aa851b4f2e279408dcec451df4%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638645028798536734%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=AE0wjSUEPnwLCPHmAI1%2BNMuNNolOf%2F15HXPIcxa6nJo%3D&reserved=0> Oct 14 Holly Goodson https://chemistry.nd.edu/people/holly-goodson/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fchemistry.nd.edu%2Fpeople%2Fholly-goodson%2F&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C7429c4aa851b4f2e279408dcec451df4%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638645028798536734%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=tnaQeASLTxs2%2Ft%2B2CfTSauX1U4RWiuPlCmmL6wjPCFE%3D&reserved=0> Oct 28 Mark Alber https://icqmb.ucr.edu/mark-alber<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Ficqmb.ucr.edu%2Fmark-alber&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C7429c4aa851b4f2e279408dcec451df4%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638645028798536734%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=BAKTT9WC%2B7FUVjXXXnugJL7RIC77eblMs1slW8oMNwY%3D&reserved=0> Nov 11 Alexander Dowling https://dowlinglab.nd.edu/research/<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdowlinglab.nd.edu%2Fresearch%2F&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C7429c4aa851b4f2e279408dcec451df4%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638645028798536734%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=VtDlPyXHqevIqZIfiR5kzNR31dRQTNodzXbPpFGmH74%3D&reserved=0> Nov 25 Gardner Lab - Institute Community of Practice and evaluation https://www.bio.purdue.edu/lab/gardner/ Dec 9 TBD - ABIDES Topic FYI: NSF Biology Integration Institutes Annual Meeting will be held December 16-18. The meeting will again be a hybrid this year with the majority of BII members connecting via Zoom for sessions, and a small group attending in person to represent our Institute. Details will be shared as they become available. In Other News: Today is recognized as Indigenous Peoples Day <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.smithsonianmag.com%2Fblogs%2Fnational-museum-american-indian%2F2024%2F10%2F11%2Findigenous-peoples-day-a-day-to-honor-and-recognize-the-first-peoples-of-america%2F&data=05%7C02%7Cembrio-list%40ecn.purdue.edu%7C7429c4aa851b4f2e279408dcec451df4%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638645028798536734%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=qTOnbfkO86RWfV8kHxIYpzQ0UFv%2BTtFqYTKO9AKklfs%3D&reserved=0> in the U.S. Traditionally, this day has been known as Columbus Day. Although paradoxically the State of Indiana (land of Indians) is not one of them, many states and cities no longer celebrate Columbus, and instead are officially choosing to honor and recognize the First Peoples of America. The City of West Lafayette (home of Purdue) is one of three cities in Indiana, and one of 216 nationally that have ratified this change in recognition. As one example, many departments at Purdue have a Native Land Acknowledgement<https://ag.purdue.edu/department/ipia/who-we-are-pages/native-land-ack.html>. See you all online this afternoon for the seminar! Brent Brent T. Ladd, Senior Research Program Manager, EMBRIO Institute<https://www.purdue.edu/research/embrio/> Weldon School of Biomedical Engineering, Purdue University Office: Hall for Discovery Learning and Research, Ste. 203 207 S. Martin Jischke Drive West Lafayette, IN 47907 laddb@purdue.edu