[cid:image005.png@01D22A1D.69EF8A10]<https://engineering.purdue.edu/ChE> Purdue University School of Chemical Engineering GRADUATE SEMINAR SERIES Dr. Jennifer Reed Department of Chemical and Biological Engineering Great Lakes Bioenergy Research Center University of Wisconsin-Madison "A Systems Approach to Engineering Microbial Metabolism" Tuesday, November 1, 2016 3:00 - 4:15 p.m. FRNY G140 Reception at 2:30 p.m. in Henson Atrium Abstract: Genome-scale networks of metabolism and regulation can be reconstructed from an organism's genome annotation. Computational models generated from these reconstructions can be used to predict microbial responses to genetic and environmental perturbations. We have recently developed new algorithms for proposing metabolic engineering strategies based on metabolic and regulatory model predictions. Using these computational approaches, we identified genetic strategies for enhancing production of pyruvate from glucose and co-utilization of xylose from plant hydrolysates. These examples illustrate how integrating computational and experimental approaches can lead to novel metabolic engineering strategies and accelerate metabolic engineering efforts. Bio: Jennifer Reed is a Harvey D. Spangler Faculty Scholar in the College of Engineering and an Associate Professor in the Department of Chemical and Biological Engineering at the University of Wisconsin-Madison. She received her B.S in Bioengineering: Biotechnology and Ph.D. in Bioengineering from the University of California, San Diego. She has received a number of awards for her research including an NSF Career Award, DOE Early Career Award, and a Presidential Early Career Award for Scientists and Engineers (PECASE). She is an American Institute for Medical and Biological Engineering Fellow and a Kavli Fellow. Her group develops and applies systems biology approaches to study and engineer microbial metabolism and regulation for a variety of applications Nicole Cox Graduate Secretary School of Chemical Engineering Purdue University Forney Hall Room 2043 765-496-0309 nicox@purdue.edu [Eng-Black-Gold-rgb]