|
|
Purdue University
School of Chemical Engineering
GRADUATE SEMINAR SERIES
Dr. Abraham M. Lenhoff
Department of Chemical and Biomolecular Engineering
University of Delaware
“Proteins in Ion-Exchange Adsorbents: The Inside Story”
Tuesday, April 12, 2016
3:00 - 4:15 p.m.
FRNY G140
Reception at 2:30 p.m. in Henson Atrium
Abstract: Despite its inherent inefficiencies, chromatography remains the
workhorse for protein purification in the pharmaceutical and biotechnology industries, with ion exchange the most widely used mode. Many aspects of a chromatographic process are still optimized empirically, but there is an increasing recognition that a mechanistic
understanding of the relation between adsorbent and protein structure and separation performance can be valuable in process design and optimization. This presentation will cover efforts to obtain such insights into the behavior of proteins inside chromatographic
adsorbents. Approaches to be discussed include powerful experimental tools such as confocal microscopy and neutron and x-ray scattering, but there is also a critical role for fundamental principles of classical chemical engineering, albeit specialized for
the peculiar physicochemical properties of protein solutions.
Bio: Abraham Lenhoff is the Allan P. Colburn Professor and Chair of the Department
of Chemical and Biomolecular Engineering at the University of Delaware, where he has been on the faculty since 1984. He earned a Bachelor's degree from the University of Cape Town and Master's and Ph.D. degrees from the University of Wisconsin, all in chemical
engineering. His research is primarily on application of principles of thermodynamics, transport phenomena, biophysics and colloid science to protein separations and phase behavior, especially chromatography and crystallization.
Christa Jackson
Forney Hall School of Chemical Engineering,
480 Stadium Mall Drive Room1060
West Lafayette, IN 47907
Phone (765)494-4050
https://engineering.purdue.edu/ChE/index.html