BME Seminar Distinguished Lecture Series

Wednesday, October 3, 2018

9:30-10:20am

MJIS 1001

Weldon School of Biomedical Engineering

Purdue University

“Molecular Mechanism of Cytokinesis”

Thomas D. Pollard, M.D.

Sterling Professor of MCDB

Yale University

Abstract:

Professor Pollard’s laboratory combines microscopy, biochemistry, biophysics, molecular biology and mathematical modeling to study the mechanism cytokinesis. His lab characterized important contractile ring proteins (actin, formins, profilin, cofilin, myosin-II and anillin) and developed methods to count protein molecules in live fission yeast cells by fluorescence microscopy, measuring the numbers and dynamics of more than 20 contractile ring proteins. Recently they determined the substructure of the precursors of the contractile ring by high-speed super-resolution fluorescence microscopy of live cells. This body of quantitative data allowed the lab to formulate and test molecularly explicit mathematical models for contractile ring assembly and constriction. Simulations of these models accurately account for events in live cells and provide the physical basis for mechanistic studies of the biochemical systems that regulate the transitions in the system during the cell cycle.

~BME Faculty Host: Fang Huang~

***Coffee and juice will be provided at West Lafayette***

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Fang Huang
Assistant Professor
Weldon School of Biomedical Engineering
College of Engineering, Purdue University
West Lafayette, IN  47907

office:
206 S Martin Jischke Dr

West Lafayette, IN 47907
Room # 2025

Phone: +1 765 494 6216