Dear All, Below please find the eleventh issue of the newsletter of the 3D Cell Culture Core (3D3C) Facility of the Birck Nanotechnology Center. The newsletter is also available online (https://nanohub.org/groups/3d3cfacility/news<https://secure-web.cisco.com/1AX3CIWzqxqcPmCxBvmXJGbwZdYBOuRy1L1pvdFqPQmlzPBUBIsqztA9nWhTWYCAXfZQWYrbhoW5hZhPcXxMwfaxzZT31RJ6KMulj73xLzAWUL3vQtgQAE7egDlumRa35nsRSjrj69dnnLJTaZx6Z8infcExJolsgS-5ra-dQH3dRP39ySz1HtzUA0YRF0LyZ_Heu3wzyo4lc5KvLYCWEsi2Vq14qyRw7r1qDnoI8z0OIv9k-JJn6frQiXlhyXcMmRHGWj_pGF6cDUCZOCyCQ3xNWbazvrnQaP2OqUgaxooir5gy1-cZRNUGeQaQxJt8YLw3K1X24VzZODavIDo4CpTbkfij91t6lV6pGEpjFhsY/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews>). The four sections in the newsletter are: 3D at Purdue – this section highlights 3D cell culture-based research activity at Purdue 3D in focus – this section presents the current work on a specific 3D cell culture model or technique 3D in publications – this section brings a collection of recent publications on 3D cell culture 3D in meetings – this section includes a list of upcoming meetings related to 3D cell culture The newsletter will be available every two months. If you do not wish to receive the 3D3C newsletter in the future, please reply “cancel” to unsubscribe. Please contact me if you have questions. Yours Sincerely, Tim Kwok Facility Manager 3D Cell Culture Core (3D3C) Facility Birck Nanotechnology Center Purdue University ________________________________ [https://secure-web.cisco.com/1oBnG52d1deHIHAeodeeHu4nS6DDWsK9BVLkL333e9QxKez...] Volume 11, August 2017 [https://secure-web.cisco.com/1NghkjAoDhc-afTKOYf7Q5BPw3-rajPg2Yz4BSDwsWOt7o0...] 3D at Purdue 3D in Focus 3D in Publications 3D in Meetings 3D at Purdue Phenotypic Screening for Anti-Metastatic Compounds Using 3D Culture Work in the Wendt lab is focused on developing anti-metastatic drugs and life-style recommendations for the use in advanced stage breast cancer and as preventative measures for secondary tumor recurrences following surgical intervention and primary chemotherapies. The metastatic process consists of several steps including primary tumor growth, invasion, intravasation into the blood or lymph vessels, extravasation, invasion into a secondary organ, secondary tumor initiation and finally metastatic outgrowth, all the while avoiding detection by the immune system and elimination by standard-of-care chemotherapies. While in vivo studies using mouse models are required to recapitulate metastasis as a whole, several aspects of drug discovery and compound development are not feasible using only in vivo approaches. On the other end of the spectrum, drug response studies using cells cultured on 2D polystyrene offer critical, but limited information when assessed in a non-biased manner. Moreover, 2D cell culture results can be misleading due to artificial interactions between the cells and the polymer growth surface. Therefore, we continually seek to utilize or develop robust, cost effective, 3D culture approaches that are be capable of yielding high content information for drug discovery and development. One current approach we are taking combines two commonly used methods of 3D culture; 1. The non-adherent round bottom culture dish, used to form a collective spheroid of tumor cells or some mixture of tumor and stromal cells, and 2. A gel based semi-solid support that allows cells to organize into three-dimensional structures. The technique consists of forming a spheroid in the round bottom dish for an optimized period of time and then physically transferring this multicellular structure to a hydrogel semisolid support. Similar approaches have overlaid the spheroid with a hydrogel, but we find that the transfer of the spheroid to a growth surface to establish an “on top” 3D culture is critical for the phenotypic manifestations shown below. The relative simplicity of this approach allows for compound addition during either or both phases of tumor growth, across a 96-well format. Using this approach, we have found that cells that fail to metastasize in in vivo mouse models also fail to reform their spheroid into a branched structure after being transferred to the hydrogel growth surface. The intricate, label-free phenotypes that are manifested by metastatic cells, in combination with recently acquired imaging technologies here at Purdue, allows us to evaluate serval data points in a medium throughput manner. This approach allows us to quickly identify compounds that may not affect cell viability, but could have potential in inhibiting other aspects of the metastatic process. [https://secure-web.cisco.com/1iWtz1etbasqnk2-MGw10mq_Xd4dU99P0BmJyY--rBfDopyi7Hz1BXw7GqAnhmy4wl4k0FF3soNv63DageMdYXk816BOn5gxHrvvb9Dg-9vavq31W11iUPrL5u0uXC3ElqwysCql1NTiFODkwnZBecp2yjkdELx8zHvq8oBRYIQMni-3FDzeSNFR14r5oTEl9MvyZ_WvuZQB5jhT451ttaaz7Lj1pIrgZktixMgcyUfGUapgFV7tkwjrOqPBDgeB_hcq4oqyiM4fsEMk0hG_fCp57XS0Q56Q5wv-l8j2Ygcr91Hwtb_X59KNoxo6tT95SnSCiK_DayHp994Q8jXq_AKQErQLavLn-a_yYtAh1LSg/https%3A%2F%2Fgallery.mailchimp.com%2Fb7d6d1ffee56a866e499104cf%2Fimages%2F1afccf40-3c85-42ea-9b21-c9cb30e030d6.png]<https://secure-web.cisco.com/1iWtz1etbasqnk2-MGw10mq_Xd4dU99P0BmJyY--rBfDopyi7Hz1BXw7GqAnhmy4wl4k0FF3soNv63DageMdYXk816BOn5gxHrvvb9Dg-9vavq31W11iUPrL5u0uXC3ElqwysCql1NTiFODkwnZBecp2yjkdELx8zHvq8oBRYIQMni-3FDzeSNFR14r5oTEl9MvyZ_WvuZQB5jhT451ttaaz7Lj1pIrgZktixMgcyUfGUapgFV7tkwjrOqPBDgeB_hcq4oqyiM4fsEMk0hG_fCp57XS0Q56Q5wv-l8j2Ygcr91Hwtb_X59KNoxo6tT95SnSCiK_DayHp994Q8jXq_AKQErQLavLn-a_yYtAh1LSg/https%3A%2F%2Fgallery.mailchimp.com%2Fb7d6d1ffee56a866e499104cf%2Fimages%2F1afccf40-3c85-42ea-9b21-c9cb30e030d6.png> Label free metastatic phenotypes in the 3D culture. (A) A schematic showing the approach of culturing cells in a non-adherent round bottom followed by transferring those intact multicellular structures to a hydrogel semisolid support. Compounds of interest can be added at any point. (B) Examples of two isogenic cells lines that were sequentially passaged through mice to yield an increasingly more metastatic cell line compared to the non-metastatic parental line. This increase in metastatic potential correlates with a drastic reorganization of the spheroid after several days of culture on the semisolid matrix. (C) Another metastatic cell line forms highly intricate structures after several days on the semisolid support. This phenotype was potently inhibited by a candidate antimetastatic compound. These label free phenotypes can be quantified in a number of ways including enumeration of branch tips, branch points, average distance from center, speed of branching, etc… Several of these measures can be done manually, but are greatly enhanced through the use of the Opera Phenix within the Purdue Chemical genomics core in the Drug Discovery building: http://www.purdue.edu/discoverypark/drug-discovery/resources/facilities/cgf/... and the Incucyte S3 time lapse microscope in the Bioscience Imaging center in the Hansen Life Sciences Research building: http://www.purdue.edu/discoverypark/bioscience/facilities/core/bioscience/in... Michael K. Wendt, Ph.D. Assistant Professor Department of Medicinal Chemistry and Molecular Pharmacology College of Pharmacy ________________________________ 3D in Focus Hydrogels have structural similarity to natural extracellular matrix and are utilized extensively as cell culture platforms for various biomedical applications, such as tissue engineering. The mechanical strength of the extracellular matrix regulates cellular behavior and physiology in a 3D environment while the effect of diffusional properties has yet to be explored. The conventional approach to modulate the mechanical properties of the hydrogel is to control the crosslinking density that in turn also limits the diffusional properties of the hydrogel. To have more accurate analyses for the matrix effects on cells, there is a great need to uncouple mechanical and diffusional properties in 3D hydrogel systems. In the highlighted article, by varying the number of functional groups on the crosslinker molecules, the authors were able to uncouple the mechanical and diffusional properties in a dextran hydrogel system and study the effects of both properties on the viability of cells. Suntae Kim, Sung Bo Sim, Kangseok Lee, and Chaenyung Cha Comprehensive Examination of Mechanical and Diffusional Effects on Cell Behavior Using a Decoupled 3D Hydrogel System Macromol. Biosci. 2017, 1700162 Our summary of the article: In the study, the base polymer is dextran and the polymeric crosslinker is methacrylic dextran (MDex) of which the functional groups crosslink with the dextran polymer. The extent of polymerization and consequently the mechanical properties of the hydrogel is controlled by the concentration of the crosslinker and the polymeric functional groups on the crosslinker. Hydrogel of different mechanical properties were prepared by varying the number of functional groups on the crosslinker (MDex-DS) or the concentration of the crosslinker (MDex-C). MDex-DS hydrogels were prepared by mixing dextran at 1% and MDex at 7% with the number of functional groups on MDex being between one and five. MDex-C hydrogels were made by mixing dextran at 1% with 4 to 8% of MDex (with a constant number of four functional groups). The Young’s moduli of both MDex-DS and MDex-C hydrogels were in the range of 1.8 kPa (MDex-DS1 or MDex-C4 = 4% MDex) to 63 kPa (MDex-DS5 or MDex-C8 = 8% MDex). The diffusional properties in the hydrogel were assessed by equilibrium swelling ratio and porosity. Both confirm that the diffusional property of MDex-DS2 to DS5 hydrogels was similar while it was reduced in MDex-C hydrogels with increasing MDex concentration. Different cell types may display varying phenotypical behaviors in response to different mechanical environments. In the study, the viability of hepatocarcinoma HepG2 cells, 3T3 fibroblasts, mesenchymal stem D1 cells encapsulated for one day in various hydrogels was measured. HepG2 cells encapsulated in MDex-DS hydrogels (DS2 to DS5) displayed a maximum viability at MDex-DS4, indicating optimal hydrogel rigidity for the cells since the diffusional properties for DS2 to DS5 are similar. However, the viability of HepG2 cells encapsulated in MDex-C hydrogels increased with MDex concentration (4% to 8%). As a result, the difference in cell viability between MDex-C and MDex-DS was the largest for MDex-DS5 and MDex-C8, the pair with highest rigidity, but showing the largest difference in diffusion. The viability of 3T3 and mesenchymal stem cells in both MDex-C and MDex-DS hydrogels was biphasic, with a decrease followed by an increase. The viability of 3T3 cells in hydrogel was minimum at DS3 and C6 and for mesenchymal stem cells it was minimum at DS4 and C7. At low rigidity (MDex-C5 and MDex-DS2 having similar rigidity), the viability of cells in MDex-C5 was higher than that in MDex-DS2. However, at high rigidity (MDex-C8 and MDex-DS5 having similar rigidity), the viability in MDex-C8 hydrogel was lower than that in MDex-DS5 hydrogel. These results suggest that the difference in diffusion between two hydrogel systems might play a role in the viability of encapsulated cells. Comments from 3D3C: Hydrogels are widely used as a cell culture platform for various biomedical applications. The mechanical properties in hydrogel are known to regulate cell function and physiology. It is still a significant challenge to control cellular behavior and to maintain the viability of cells in 3D hydrogel systems. The highlighted article suggests a feasible approach, shown for the first time, to uncouple mechanical property from diffusional property in hydrogels. The results indicate the distinguishable impact of diffusional properties and mechanical properties on cells. However, in the present system, scientists are still unable to change the diffusional properties without changing the mechanical properties of the hydrogel. To demonstrate clearly the impact of diffusional properties on cells, another or an improved system will be necessary. ________________________________ 3D in Publications Recent publications on 3D culture (please click to access the list on our web page https://nanohub.org/groups/3d3cfacility<https://secure-web.cisco.com/1AYSCmJv8FuJ7lii-f1gDvENX3F5pnL3gpF9ESkhViUR5iOP1kqLMiwR-49LXSdMtqM43hdkF_q3Ew1L5am4Yh-MjK3PvC03vmMpAVjNLLsBoA2P00fLspmGGUyTHGalYtUEvZ1wrG0D2NOyKcx9jFDwF5J3JujtuzoqeaXIJq0dKLABLIp0oXdbx7vV9fE6t1lzT-kV2PXt-GROP3zsscZhafp-TbpGd6GBhPmA-17_R7osims_Jr6Ak2Kq0VmsX2K-Z5ktoEYI1SE7Gr4B5c9cCANqAYEawtqc6hQ_kUKTTu0B4uk0tL-qqkjFa6jnKd8W8vlJuE9IG7DmMKyt8CEsp1_Z33uaJPu6IyrHJtyU/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility>): Review<https://secure-web.cisco.com/1G78nY7-dIkhuTPHmk2qU8XFjjFC4S-otS5PVH09oPJ13kAZ1E6AM2-JHK3850swy4Kt6yM8C7zLjwyCuVEoE4nDNbUNmnvl_walT5jcEjK1lIUw7UnH-s4vDAghDsEhUKti_vvoNk2XsatZiXP73ZiyPmqy0q4RR7pPpiXfNOugHM4FuPBtXbe89nm4nS_M22_qAxI2lc4AZVPfRSOH1-xrxAOrNPh4Aa8c8DIgPTSZZoo2ALVfr7wHKYiIDMeKGg-FD-7zqnJm3NznHHtbltVUguoErgY7vOD-o6ujeAiKJJX-HgN1z2jgU1uvF8Sxv2iVamhmsyx54qxSG9cKmxgJy8a7bxm-Mj1CpVnqrIZw/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews%23reviews> The research articles and reviews are arranged in the following categories: Scaffold free/Scaffold Organ/Tissue/Cell Others 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Muscle<https://secure-web.cisco.com/1xOS2cIfLEr6N1Dik87q74A9MIFZMqtD9zutRywVHW7IHLv2e0oH3pIaNGZuA922b3YlALrBCIKgU4h6OsSy_lRyg_hPP72nycXp1ZFQ2WkbtQZYIV64wcvMNAX2u6k60SH2HCtMnQ-0nLVfXWNxZOPAPCfPD9ES3uy7oGqscrTms0w5u3WVBa9zVmmcl0HEIri-icdRX7MeQT-5ap8_LNVkPOVwbRiJiIuNuf9gWTGUS4LkBNUd2ZX5yT6TAx868Z4fYESNgLZNUkwjrRQoLk8j0WJD8A9AvyIlybrslEmwUUUMlabfN7UjlhTbPkS6pkW4akl5cOVFi97glaySoD29leZM0qPBZ6J273KUZwT8/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews%23muscle> Nerve<https://secure-web.cisco.com/1ln8-BMipHjJKnI_Md5eOxPjB6wCW_Vj2JgSvQp7dEieHGTU6dYkhMCyt6ffvxjDe9IBhR5HG9hDBIvps9JTHz8AgDyl0alWWSO6UkoFDHC-VEJKI-GjGKKbAPlBYTCTeKja6H2EaOyHN-yxhT8FvYP7SpDbtfRDy1sru9VvSDAnI621pxvfO6LamEDCfTGMrwsglWOI1dijiLeUmDEsmbIvQozrE6lireB9t_KN50ECuV-qEkaGoneZ8Sy7PabLjUoDeA_QYGpIIwxjeYfXzwJqBymm4X_Ki22QQnuEzdXBS-g5BsMBTLdJra8BjdDMpp_a1vO-695h-jgarExSuUDfe32KmjLgMN5KSjrV3jfA/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews%23nerve> Prostate<https://secure-web.cisco.com/1-zFZueiQ3mFB18oz6xHXeCI0dk38T4a5KsmOumsHMC4-Wvn8PAN1G-w6rHCWQl8M06TgDHE6zvxfjWkmucXQH4tKPlsTounQaxRVeZXcCqNXzSP03CBU-axUcIytTQ9t-miP5xCQe-6KZ6wpyvgunQRl7p2-5Su9gk1XhFtlpkCj2sWRHsMzYILVWXI2At8GJQpdek5gKoao8TmQR45rc-N4jcEkVHovVsSqei_MB9qIE6TlvRgLGT5q2-pYmway4yMPq6xuU_CXDQOE3RqZuoIJ01c3UOPUbpU2N10tPCedSJtyUyq87EBdOLIIw7h5m0A0FpL2T0oAO9ne5dbMabydikBQUxtfNY0h3foPOTs/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews%23prostate> Endothelial cells<https://secure-web.cisco.com/1NPlXXUGi1yq8W9eEvfWvlqQRshtE2XlMWltO-nWwo6pf7MH13Zk-i4nl9L4UyaXxAkL9AD103_ClH8pvsbZy2HAxc3kr4AiYv1R59MW1-xuzQTTKpCVLbmH8_INMEyYqPnvkuSJKdchkziLft4m4-BUTyU8cfCnI7W4Dwg3jgMUiVoAkmpCeEPn6PFu1VWmHlqEQ-STDLp_SCNsGaBZwwp3TX37VknHNsMOPnRvIIBJX2fRmoGPAiGpmUMTAFTFvQ7qXuyPuVHz_noeYF7aMCkuvEioD2DW8kgdV3Ars0y3_s40frGX72k27A9zzv8jGr8tGS3R8dGlLR-HEoQXoa3vJ3INg0f9t08VJsTvb974/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews%23endothelialcells> Fibroblast<https://secure-web.cisco.com/1M2q0O_ZvlIFHMSR9DRzyVCfSBmT9w26npYS3nO-xGnFCvf93Uh-x8EP2nLNn2HxLzRHa8ORwUXbtvaIoCX32Baa4fGbVhy0STrV0Un1tjjj2qHXb79FHSQpXHav4tBpm6YQUTBbCVYbeveEFcBpzxdcAkI4YYIcsgwsYVQazsNF1VAbFcP7dEDnfKGCi8afzl5nkDtYuwY0bc2DtRAAN0tx8QiFkD5TZVKmRNQbL_HwNwSHM7TSaluDK751gAjo92tBCVQPG3BFoFO4QM4B2adSNLWp0qnC2GQv3Kar7cPAxUUdIgOH8ckja98OqWOyq33sJUzxJBQCgrF5N2tzSy57nsYqSGapcW8th86BltJU/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews%23fibroblast> Stem Cells<https://secure-web.cisco.com/1asnb11QOaQYMnLFswqwaOsGLQ-1yvv6rPbUtmhJC7Ujy0wizUxOD99VtZgQ5lYYm3oKWPdH7JBpC0GPV3kjwjxz_dQCpFJjv___A5GnXqZ3pbPnXtmkZyb3kPRg89CgVDORMWa6AqeuO029QvkgotL18Y9bW47BecszwJ4ZAVW3IR3lJHgzlcPmj_0YRjdkcKogPI4i35PlgBcRWfMfuMfaMqgBuBZ1Dm8--N1jGdDIvVbfhD84NjqIrFKLzSmZoJJC_Ae-5SkqzPgvRwoOZFQNgxanI66u87BGJU5MMRigDyyKLzb4gfqet9TsMzBxDldxAqFyMPxots97Q2P358tShgIeXET4L4jPW0lz24pQ/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews%23stemcells> Stromal Cells<https://secure-web.cisco.com/1Y1NN6DW3orLYnUC9Mb5Lc75tsAEMoijuVA981kcyEWi2rISij3SHX4Yu3Vvr6Cydxxe3phXepqzilDKRfTIh_OuSmOIAkIjfVB5MLTCphbhAUWAeP3emqiUymrsP0bwHuputVZCDGuEhlh3BQP6FfH2sOorkq0y3RetUuzM74DjdWT28Xb0oUHQ-rYBlUqeIL0Kfhniy_BaPJYhk4-COfLWcnzXgCt6DEhVC3j5jKUJuIEQrOZRN_5qDONLnqy94hok5wHYfiXFtRtt3Tor2MK9VO2z5lDetAJRXf9i2Q7MTuXXuYwJOfknVr3TVAoXKwcrTiRrWqXy_47jG4XOLUGPlhj6YCCHQXRux-XJWq78/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews%23stromalcells> Cancer/Tumor<https://secure-web.cisco.com/1hQM64Qjkl85HCltpZdFMsIZAJdBAjx4SXpSL1ftU1sxpOxVNuM2wX2PNAcL-CIveoFricdHFGntvpRLKtj-GOXrKBCPckfAd4aCB8Ku8C4MdkBLnDew-36lz2UwxX6L28H5Iqy4peEiKgt5d6vCLtFG_tnAZcj_VnieLlBV1CCleaau0RzY41e5NQTTU4vTwuxS-RsEt22rev5xhp39ASHJernU1GWZangdsDQMEb7_vYxD3UVLfco8UHB1fPSH737ugOFRmso7SzWucIwE2FuctDnwF13dMqn2Q07qHcnIPT0rtPZ6bpjQHaQ7ZrEKLeNb5H3vGijlrLf_ctlq4FzwUTxG0boYxY1sdJYN7CrU/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews%23cancer> Screening<https://secure-web.cisco.com/1CztVvv9aD-J9lfAVyaNzaFs-5KlGpbqWcHNdJwfk-3CiAVrm4G_8V-jtIAee0O4xMpv5IFEl50Pt9umcbZ3hI7er1LtQkJYFyrg4-q6fbEfZfylxfrL3hEdqBlwC3sMaJtb3mQ4PnCW9iuiIAZdvgVZZkctoqQgqgCVM3548HsPAx1joDSJjeUj7FndeOe7RUjRt4dkHfP-e-CtBD8mT4bFZi31vgdTPOF4LBE3RxyWAu5nclT01fyHZDcZek6OcA1C8GUFJ36REDKcbj2z9RWj6Hk4z13Wd38SCYMPfl1-Qr8s9GOEXGBVxWph2_ep3hC0dbE8m8hTzP9hobiJ-RKl72vF4WVU0Nl8fHd_BKK8/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews%23screening> 3D bioprinting<https://secure-web.cisco.com/1Uu4nqP3acPaQpNZ2XVCU6bvgTZBdnl8Gk7PgC9nxIQp9Rs7hgHpXwKNKeAXBTvkjbQ5E35gMzUe24JbpCl3-VAccvVzeBXZp5OA_MLldU0pJ62u-Gq6CsJVW51yTXxw6KXJ03qMIx4ut_7a8NVpMld7WOtJnnrP0LeUA2JfRgoUNrRTabxErO3FRJ8EIo26W7nfRWxe_fzwKsojhfDEeoD3QNZpz2vF3Q7KvkuRJNab1GephoAIOd50MNwOOV4bWQ5z8dsn2U4TtA0M5yaxRjTZEZ4rof56oJKdwrTZZsur78ABzsF4s9FWucoPXWyuQ-E2NmNkx_BlIeqW0piHVbbpoj0TgIr_em9i1BVmGbGM/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews%233dbioprinting> Imaging<https://secure-web.cisco.com/1s_LPHzo053r3jL_2-j6D0ROSoouFBDQUexqRojRo2IbwnW9Nn30XJK8yA9pMlamCLkZg0C-WnhXo0A2BLzdqhmxFzYiKjAf1wFBgV1o_b-X8JBHXAIQt0_Tw5-VqSiLteEnWdGxJjbaXfd7vu1cuCPnSE_1Ko_pyPP8ImevJ8meFcH2yfCThwZdL-b7FUY1IuPCIBYIx1LewTaRPZY7D8heMUo0xlHjX27YCa15hd6UnLxjODKpNxqVM9gdrIZjhLk4wa1Ez6brmGtEaR37tpKyq-xLf0RxZLeXGBjHpBiMTmEFv4PZnxslzkn1D7fGd_lz9CMrDTddKO3grtnVyPQ-NOQPtKeaw2bkqzH5Q7ZA/https%3A%2F%2Fnanohub.org%2Fgroups%2F3d3cfacility%2Fnews%23imaging> ________________________________ 3D in Meetings 3D Tissue Models 2017 Date: 28th to 30th August 2017 Location: Boston, Massachusette, USA Website: http://go.evvnt.com/120739-0<http://secure-web.cisco.com/1fQoS8B1J26i2LgNkgM1XJXPxogyLqlqSyvKJqTJP08FMPgJoTOh2juMSPxPGGaVXs9IwrZfHYk33u9e6oZE_6Sy7HWlmsXn0owhsTv8uJ_rVsZwpU6DdmNpW3Rc3f0_vSD8E-oYtGhzIV4PuHhSwaAwrFlOWuhuLaEx-JZFi7EsuKGWE_xEmCQW6VNCfQa4mt5j1Duk81VagcDNv24YMdjHGvhriiPkGtkHz7peXOH3xcnI5Ig0Tmrofy1f1VFTD5s7imsmcAxOI4wK8sqieU1VmS8Hbhl3UWewKpbhiW8cMSCznj-HOvYdSfwrQp3iOtnuottxxXQbR5XnJMnuLiLHkFvLdYe7FlTo8JUi9z_kNJtd6P7dWXoKeEkN6Xt2f/http%3A%2F%2Fgo.evvnt.com%2F120739-0> Contact person: Customer Services Organized by: Hanson Wade International Conference On Nanomedicine And Nanobiotechnology 2017 Date: 25th to 27th September 2017 Location: Barcelona, Spain Website: http://premc.org/conferences/iconan-nanomedicine-nanobiotechnology/<http://secure-web.cisco.com/14XlZfz-qi2TDn5tqckEV0x5qCIBQw7BX3e3meX7RMVVas8wRbUmw2fo71nW_wKPRf4DIpZRTTWUIAMzEy5CICmT7vEaT7XFqOFWTgjeSzahhYdH-pI9sJpR9aI15Iri_JGJ5Ats2mRuayrJXUWgkK6bAbUapAkuBwADzRe9rgjMuhwKNFkvMw3iC-gYgZQyA4UXRIdRuFX4Lu6D_SkWHM1vRKacWeA7n8kpN54zCCXYWtOuJYoMZP41Y49g0I1Th_WNcB2WRFLLJF0mcDKqvWNtgzyWD7ucmuIfVpwv5OUXTlN4G8XyQ2rPtd3DN2oJDzH3lsVZ5S12Cvoy55v2Wz4YpI9-xxw8oC60Vu8Yw7PQ/http%3A%2F%2Fpremc.org%2Fconferences%2Ficonan-nanomedicine-nanobiotechnology%2F> Contact person: Samuel HADDAD Organized by: PremC Deadline for abstracts/proposals: 30th June 2017 Bioprinting and 3D Printing in the Life Sciences Date: 17th to 18th October 2017 Location: Cambridge, United Kingdom Website: http://go.evvnt.com/113717-0<http://secure-web.cisco.com/1Rh6IsBCS-Nvcsp53GalQWcQKcEAb9NGFmOHadYnAN1ttGvm52lcv4NlpAWZa1VrXntmxEKt2C6qaVz70cDhkmR3W3ncEIFoI5uc8s580ZjojwMa6_nQt5J22TKV5QNR6iaB5sxEAZp04oICLggcOaLQ6V1cmTySm4rinGiHQf-VmGxJtEEPmXDkK3z7gwJ2NQ5iNfU4bhR53x3RFQuDyQGTDomIeA4nOBTAb508_ZE_I387MRKQGa4Sskr0ba-HPnRl8s5kjDYXbUAiRXr0VJmXh5b98Wb196m_su3Kvf7n4DO0sOgRTdTY2v30HMOR_yejjqdMf56BrFilvJRm460FgQ1IGGJS40vGScyMJP2sFvyRB9V5As9US-OsgzHL1/http%3A%2F%2Fgo.evvnt.com%2F113717-0> or https://selectbiosciences.com/conferences/index.aspx?conf=B3DPLS2017<https://secure-web.cisco.com/1TUMPvwIyGgALX3DaX1vD9Rxbw7wEvD6Y2Rr2xlgs4mbzmD9nwmG3F21Me2u8hb1xAJuFWt6lUleMU7LjTHJWh2Cl7p8EJGvKFGWc3Yh8IXmFIiuuA11s9_rtlOnrOa8EBNkC6fVdl679VGBVt6zRouHMBt1xL2z1IQVH6MMOsXeO1616swdN8EzsGKYOA1rx28CYc4gly8KLwFww7MF6epS2jXZ_xxPjYqiJpBJHjzjsj6sM8sULGD1xJFI7VBDNbvRaAGUeZckRsCWgySjSd1Q46LoF7z-NXJk0OaU2a1K0tqsjbcMJg-huv2wG1NBRIia-Qvh9pqNR0eTrf4vrmN0gv2n6-GvKYWymiPo-l90/https%3A%2F%2Fselectbiosciences.com%2Fconferences%2Findex.aspx%3Fconf%3DB3DPLS2017> Contact person: Sara Spencer Organized by: SelectBIO International Translational and Regenerative Medicine Conference Date: 1st to 3rd November 2017 Location: Barcelona, Spain Website: http://itmc.madridge.com/<http://secure-web.cisco.com/1OlSmOXsKBGlwy-oogNQrZgEeSxJQHWsEKXM2-a9jcU91ZIu7fbB6OX-HZLVLM3ERkS3w0GI4rSjVDi7ljKgHbePTyi9hTe7zjNnCnucm7kaGHWzuCUtn76eI-wHkJjN4BEjgjxBoYKBcdSZlP-lvVx387A7MStZxz-SJ976s3oUTyOdvzjPO_m43dA5BnCSS50vC-IFTpqcJvqpnL53vZPVOHvnf_OuDc_l0PXwR4pO5c5htgiGvPinOMh1dw60fyIXHO7o-Xy7fHL2nUQl0xE3QagU39AGEyP6g9ot9v7hDZkVxKJAV67T4rTna0uac1PYAdZEC3Z4-hxMzDTAmIycZKqCI3062CKvQHwp2fiw/http%3A%2F%2Fitmc.madridge.com%2F> Contact person: Samatha R High-Content Analysis & 3D Screening Date: 6th to 8th November 2017 Location: Cambridge, Massachusetts, USA Website: HighContentAnalysis.com <http://secure-web.cisco.com/14ZHNpsrk7C5CeIsxsaOlYunuLl3x_0MKHy_Wf4b4x73KnzF3EiGRNZDyny5fT85aoovYqlKPqPiuYs1PGuE2aIfBzzPHsiWLJ8U5Cxt_3hWlw3mA8zVOLT9izzY09r0_OCSMkOEVqMwy7n0obVX0kpGHKvsHyFtMs8gEARn7s3P7p3WTrnoFcS6mzyz6_0G02Ur0VFBNwZtFvOq8iw0ao5m57SbTsl4i0J1vYlUYKb2x8e5_7jsKpQwvsGbQwaXrgJ7avjrnU3Pjn-qa7FMOhTC3amhdjTQD2QEnLYJ5Pr4WqFZsLDfeRpXrZ9XiluArCQPyPHgcQA2fq6rKjEaqIk8hc4j6lQwLy3uXU16mueU/http%3A%2F%2Fwww.worldpreclinicalcongress.com%2F3D-Cellular-Models%2F> Contact person: Jaime Parlee Organized by Cambridge Innovation Institute World Preclinical Congress Europe 2017 Date: 15th to 17th November 2017 Location: Lisbon, Portugal Website: http://worldpreclinicaleurope.com<http://secure-web.cisco.com/10xOqG7KeU3lXFun0V0Hw_aw0JSXTiFHAOpt7q6G7pLp8XpP8GAF0UUaw8VCSSw7idCqd5fGJVf4CG9IdyAoSkLbknaIW4i5bTggZyDXaDH3PTmvzACtOB-GDE7eEKvk_E669ecKMgRIwM6heUE5hROTMkcYMGlNtIawKc6D9Vn6_ZI6NvlLzAtb3Ad86rzuzDkMmK5qxwrNGp8z-dcjoShARiBkL0AWkDFNx7Br6aQncV2vN6kRNVzgr-5XIdYteeLHRvepUtuLDX98_ZReYv7yZpBYqqTqqHIa_8j-q5-rTKZhBjl0eWk0Q8wuaf6zakr7pEGLOm0e0NWOy_x_XfvZY060HEvm22gHCGonfZvc/http%3A%2F%2Fworldpreclinicaleurope.com> Contact person: Bethany Gray Organized by: Cambridge Healthtech Institute International Biotechnology and pharmaceutical Industry Forum Date: 11th to 13th December 2017 Location: New Delhi, India Website: http://biopharma-forum.com/#1<http://secure-web.cisco.com/1ld6GnIeOtH6WSfaeMbsDUqTcKB9AhEeBPR1qrcb0HGZhyQ9g_pBeKIegA-13-TujmDQS45aUSq6lAHoy1j4XASuUHzNNVmGehfPkZqtgXzrdWq1ItspKWRTJzQQCJM4ryXiqkg1ZLj-R21dXPnY6xEjKmWo7UPhk4asUfKqyzkS9-6dhzLZW5WbTo6sOzJcr1Iv5wxfjujR6EZl3Aq_Ux8ByP0oQgZBunHJ7DQoYfyaS-xQQKvWeVs0YE-t9Rcjqm1SoC2W7J38L8EmKu3XAWls_VzbltMLgqlLy_UORupyhU8kg-UG0I_hoEkB7KSQQaC4mM8dOC0VQ5_JcvSgqXXrsYCAEvvw5WMH0fPNXiRg/http%3A%2F%2Fbiopharma-forum.com%2F%231> Contact person: sangavi Organized by: Clyto access Deadline for abstracts/proposals: 25th April 2017 ITMC-2017-Aims to discover advances in health practice & in relation to health disparities, as well as a breadth of other topics. Need for translational medicine, Challenges in translational medicine, Opportunities in translational medicine. 3d Cell Culture Date: 21st to 22nd February 2018 Location: London, United Kingdom Website: https://www.smi-online.co.uk/pharmaceuticals/uk/3D-Cell-Culture<https://secure-web.cisco.com/1ItyrP-xRYjhw0p-1nog1vjqZ-TwoTXi9uvSAscrx3IglupeDFelS1zJCA_mTA5nbKlHtuAatazISUiNuRFR0BFl7SFw1tJfrubeiuFgTlYFPwJVMpVtfL3ELdXbGcNTB9mQ3UOw53ZUgNee1x04gfy3isglOZw1WGdREHDVwE-JS0IPzAxNG3gYC47xbwCVivZgzuZd5DK9VI6AddZQd89UEpxJTaO0bdITGzM4s1yhT8Eqie9BpTGvU4GywDLevcCPGxm4ssbBqLIdeYz1qpray_sbeSHDoFZGLzBLn15b-dD2Fdx_Bh_XyqeHyJMkHvGbyGP8oOF1sxu9MCvr9d8aiyEqTbe1ILn9jI0ikdCw/https%3A%2F%2Fwww.smi-online.co.uk%2Fpharmaceuticals%2Fuk%2F3D-Cell-Culture> Contact person: Customer Services Organized by: SMi group 4th International Conference on Bio-based Polymers and Composites Date: 2nd to 6th September 2018 Location: Balatonfüred, Hungary Website: http://www.bipoco2018.hu<http://secure-web.cisco.com/1dKAqnqckGq3e16EeZmYnFbxBYGhR0TqoZoqjYaKjhSKpTJYnvKIq4yfDLk9UVrtbvWOwONcd8unXAu23TBvPAKsIOYdtoRpzDI5EOSSFncHOrNTPq6h1md_PgGuPFhEnKI4_s9jEkNv9FmdJmZ7V42Dfjo6hkGVuke3hlaOaETERnlgUMfMI-o41GCKcedLwAcRmNQqy7IemSUM4nm5CkrFKWHE-6TP5SkQu9iXUKGAnAApRWwHyDI-cXlp7Xrbh-LaQ1_5S_tA51H6Nbi8xyDe65bxTqeVKjToTlqk6oD9Bz-B9iSwwOe3yBKvUUFmZte4T_qWwCHJYPBAyyXY0zrZ_cLz07pe0jsbeQ4X14yY/http%3A%2F%2Fwww.bipoco2018.hu> Contact person: Dóra Tátraaljai Bio-based polymers and their blends, composites. Natural polymers and their modification. Natural fiber reinforced composites. Other raw materials based on natural resources. Biodegradation and environmental issues