Hello All - Seminars in Hearing Research at Purdue (SHRP) Date: Thursday, April 6, 2023 Time: 10:30 - 11:20 AM Location: LYLE 1150 and via Zoom Speaker: James Bundy, SLHS Title: A New Model of Auditory Aging in Chinchillas: Chronic Application of Furosemide to the Round Window Abstract: A New Model of Auditory Aging in Chinchillas: Chronic Application of Furosemide to the Round Window In humans, hearing loss can come from many sources, from hair cell damage to degradation of other ear components. In auditory neuroscience, a hotly debated topic is which factor is primarily responsible for age-related hearing loss (ARHL). One of the proposed causes of ARHL is a drain of endocochlear potential, which is the battery that allows hair cells to transmit electrical signals. This battery can also be drained by furosemide, which results in temporary hearing loss. To measure the effects of the drained battery alone, in 2004, David Mills and Richard Schmiedt used an implanted pump in gerbils to apply furosemide to the middle ear over several weeks. Mills and Schmiedt found the chronic application of furosemide in young gerbils produced readings remarkably similar to aging. The present study examines whether this approach is possible in chinchillas: an osmotic pump will be implanted and furosemide will be delivered to the cochlea. Compared to gerbils, the auditory system in chinchillas is closer that of humans, and due to this, chinchillas are a more established hearing loss model. However, chinchillas' 15-year lifespan has limited their use in aging studies. Here, we propose a model of ARHL in chinchillas, which will allow for more powerful studies in the future to analyze the factors contributing to hearing loss and how they interact. This may allow for studies in chinchillas that analyze differences between hearing loss due to noise exposure and hearing loss due to aging, which can lead to more individualized treatments for hearing loss. Zoom link for remote attendees: https://purdue-edu.zoom.us/j/4326340458 Meeting ID: 432 634 0458 The working schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule The titles and abstracts of the talks will be added here: https://purdue.edu/TPAN/hearing/shrp_abstracts Christine Reidy Senior Administrative Assistant, Bindley Bioscience Center BIND, 1203 W. State Str., West Lafayette, IN 47907 [A close up of a logo Description automatically generated]<http://www.purdue.edu/>
