Seminars in Hearing Research. September 14. Edward Bartlett. Nelson Hall - Room 1215. 12:00 - 1:00 pm
Seminars in Hearing Research
Date: September 14, 2023
Place: Nelson Hall Room 1215 (located on University St right across from Lyles-Porter).
Time: 12:00 - 1:00 pm
Speaker: Dr. Edward Bartlett
Title: Spatially-specific,
closed-loop, infrared thalamocortical deep brain stimulation
Brandon S Coventry1,2*, Georgia L Lawlor1,2, Christina B Bagnatti1,
Claudia Krogmeier4, Edward L Bartlett1,2,4*
Abstract: Deep
brain stimulation (DBS) is a powerful clinical tool for the treatment of circuit-based neurological disorders such as Parkinson’s disease and obsessive-compulsive disorder. Electrical DBS is, however, limited by the spread of stimulus currents into tissue
unrelated to treatment, potentially causing abhorrent patient side effects. In this work, we utilize infrared neural stimulation (INS), an optical neuromodulation technique which uses near to mid infrared light, to drive graded excitatory and inhibitory responses
in nerves and neurons, to facilitate an optical and spatially constrained DBS paradigm. INS has been shown to provide spatially constrained responses in the cochlea and in cortical neurons. Unlike other optical techniques, INS does not require genetic modification
of neural targets. In this study, we show that INS produces graded, biophysically relevant single-unit responses with robust information transfer in thalamocortical circuits. Importantly, we show that cortical spread of activation from thalamic INS produces
more spatially constrained response profiles than conventional electrical stimulation. Owing to observed spatial precision, we used deep reinforcement learning to close the loop on thalamocortical INS, creating real time representations of stimulus-response
dynamics while driving cortical neurons to precise firing patterns. Our data suggest that INS can serve as a spatially precise and for both open and closed-loop DBS.
This year’s SHRP schedule is available here: https://purdue.edu/TPAN/hearing/shrp_schedule
Titles and abstracts of all SHRP talks are here: https://purdue.edu/TPAN/hearing/shrp_abstracts
There will not be a hybrid option this year.
Talks will either be held in-person only or via Zoom only for long-distance speakers.
Christine Reidy
Senior Administrative Assistant, Bindley Bioscience Center
BIND, 1203 W. State Str., West Lafayette, IN 47907
