[cid:image005.jpg@01D9C906.3EE5E1E0] BME WEEKLY ROUNDTABLE August 7, 2023 INTERIM HEAD'S NOTE * In the past few weeks, together with Vitaliy and Young, I have been working on the committee assignments. We announced the chairs for the undergraduate and graduate committees in the last weeks. By the end of last week, we have finalized the committees with quite some discussions. As we navigate the ongoing changes and challenges in our School on both sides, the committee members are critical to our School's operations in many fronts. In addition, the committee roles are critical in collaborating with our colleagues in Indianapolis for the development of the joint program. Vitaliy is sending out a personal thank-you note from the two of us. Here, I want to send my sincere appreciation as well. Other committees are also being finalized as we speak. Several chairs have been looped into the discussion. You may hear from us on this matter soon. * On 8/25 (the first Friday of the fall semester), we will have our first faculty meeting. With all the changes (not only administrative and organizational but also incentivization opportunities and performance assessment), I have invited Dr. Wayne Chen, Associate Dean for Research, and Dr. Luna Lu, Associate Dean of Faculty, to touch on several topics in the latter categories. Thanks to the staff and students organizing the Ice Cream Social, which may have been the extra motivation for them to come. They have both told me they want to socialize with our faculty. I have made requests to schedule information sessions in following faculty meetings on various important topics, e.g., COACH survey; faculty recognition. Let me know if there are things you want to hear from various stakeholders in the college and university levels. * BME Summer Seminar Series of this summer is coming to an end this week. I would like to know how it has helped our students. In addition to my priorities (helping identify strategic important areas for the School to grow and assisting in the establishment of the joint program between West Lafayette and Indianapolis), I take special interest on the issue of how to maximize our students' development (both technical and professional competencies). In the past few years, we have made great progress in this regard, and now that new interventions are in place, we have started to get feedback and comments. So I am all ears for you (faculty and graduate students)! UPCOMING IMPORTANT DATES Week of August 7 Wed., Aug. 9, BME Summer Seminar Series, 9:30 a.m., via Zoom. You Zhou (Nan Kong, advisor) will present "Assessing the Cost-Effectiveness of Public Health Policy for Smoking Control through Microsimulation Modeling on Cardiovascular Disease" and Peter Zoss (Matthew Ward, advisor) will present "On the Structure-Function Relationships of the Mouse Common Peroneal Nerve for Bioelectronic Pain Management in Joint Disorders Wed., Aug. 9: Poster Presentation Applications Deadline. Registration<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D64a48a732b411d0c2653914a9390c9700ef88f4838882aed7cec562770f30bf0fdadcbbca8663e39d457feedcfe52a22b62640b2b638169e&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069164865754%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=BLX16t1vo1bC54u2bidv%2BaRdUwU3hNgrdc5z9jGL5vQ%3D&reserved=0> is open for this year's Indiana CTSI Annual Meeting to be held in-person, with virtual option, 2023 Indiana CTSI Annual Meeting on September 22, 2023. As you know, this year's 2023 August M. Watanabe Prize in Translational Research Awardee<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D64a48a732b411d0cff0679d5f37ecfaaa90dd5c13901928a73b80cf3aac5c8667cd6a5b819902927e76d0fe5584ad38994e5a413c48f2fa1&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069164865754%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=qLV%2BMOHT7JHVAH6s4079urVe%2BBZMBbEy86ZndBpOzFw%3D&reserved=0>, Huda Y. Zoghbi, MD, is our keynote speaker. Dr. Zoghbi<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D64a48a732b411d0c1bc62022c033a88a3c2165789225fd8c6537727e5cb9a9e848b9482b31989500dab72de55ebb6bed567e1380f6afa587&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069164865754%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=LNgB%2Fm4kMALpVfaATdu6HueIilltUZjkDX0BBjSQSGM%3D&reserved=0>is a Distinguished Service Professor at Baylor College of Medicine, director of the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and an investigator with Howard Hughes Medicine Institute. In honor of this year's Watanabe Awardee, Dr. Zoghbi, our annual meeting theme will focus on translational neuroscience. Thus we will be showcasing the Indiana CTSI's cutting-edge research in neuroscience and related topics from across all our campuses. Importantly, as part of the day's agenda, we responded to your feedback and have dedicated a separate poster session along with more opportunities for networking and building collaborations. Our complete program is being finalized so please view the <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D64a48a732b411d0c9425fbd69c88e0407a4176fa51d886515d157c174b4d5902068cb57902b265f2657339b3f7626fd8ef208e725d865283&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069164865754%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=WUUyPwLY52tgLK52QjHM6zFKZDxOiJdibDDQAmYy%2BMY%3D&reserved=0> website<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D64a48a732b411d0cb627b0938d5a5cd61b3b774bd7b2f513df295ec6354a7440c8dbff237cec31ec5ff8dccbde38651b0aaf8d16a64b7694&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069164865754%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=oj1TFo2M%2FSMXpQgN9nN2ycf7jljB30zgolW7XOpdnow%3D&reserved=0> to stay informed. We are accepting submissions for in-person poster presentations. Research topics across the translational spectrum are welcome. Come showcase your research that is making a difference! The deadline for submitting poster presentation applications is 5:00 pm EDT on Wednesday, August 9th. More information is available via the registration link above - please note that you must register first in order to receive poster submission details. We look forward to seeing you on September 22 as we highlight the great work and people of the Indiana CTSI, and celebrate our efforts to advance health research in Indiana and beyond. MJIS Updates PLEASE NOTE that new seating assignments will be distributed/enforced for the graduate student seating areas in MJIS next week, based on the faculty members' requests. Due to the number of incoming students, rows containing three seats WILL have three students assigned. Please be courteous of others, and contain your desk items within your assigned space. Do not spill over into another student's seating assignment. Procurement/Purchasing Update A message from Zac DeHenes, Operations Manager, Engineering Employment & Procurement Center: We've had several individuals reach out regarding broken versions of the COE Purchase Request Form. I have updated the form and uploaded a fresh copy to our Procurement Center website<https://engineering.purdue.edu/Engr/AboutUs/Administration/BusinessOffice/procurement>. I have also attached it here for your reference. Please delete any previous versions of the form that you have to help ensure that the updated version is the only one circulating. Important ISS Updates As we enter a new academic year, ISS would like to share the following information with the advising community: Official End of COVID Procedural Adaptations Earlier this summer the Department of Homeland Security announced that COVID-related procedural adaptations for international students would come to an end at the end of the 2023 academic year. All international students must meet minimum full-time enrollment requirements each semester as defined by federal regulation. Minimum enrollment requirements for international students are: * Graduate students must enroll in and complete at least eight credit or research hours each fall and spring semester (unless it is the student's final semester). * Graduate students who hold a graduate staff appointment must enroll in and complete at least six credit or research hours each fall and spring semester (unless it is the student's final semester). Distance Learning No more than the equivalent of one class or a maximum of three credit hours of coursework delivered via distance/online/synch/asynch may be used toward an international student's minimum enrollment requirements. Final Semester Students who are in their final semester MUST be enrolled in all remaining coursework required to complete the degree, they must enroll in at least one class that requires their physical presence on campus for most of their final semester - even when summer is the student's final semester, and the distance learning limitation is still in play. If students have questions about final semester enrollment requirements, please refer them to the ISS office. ISS Contact Student Services<https://www.purdue.edu/ippu/iss/student/StudentcontactInfo.html>. If a student is not properly enrolled during their final semester, they will lose valuable post-completion benefits which can severely impact their future goals. Experiential Education and Employment Reminder All off-campus internships, co-ops, externships, practicums, volunteer opportunities, fellowships, and remote work for non-Purdue employers must be evaluated by ISS to determine if authorization for Curricular Practical Training is required to participate. On-Campus Employment Restrictions On-campus employment is strictly limited to a maximum of 20:00 hours per week for international students, while school is in session. Students may only exceed 20 hours per week during Spring Break, Winter Break, and the summer (unless the student is required to be enrolled in the summer session). Thank you for your collaboration and partnership as we work together to keep our Boilermakers from abroad informed of their options. If you have any questions, feel free to contact our office during our phone advising hours (765-494-5770) or email us at ISS@purdue.edu<mailto:ISS@purdue.edu> (note: the ISS email address is not for student use). Upcoming important deadlines and information Wed., Aug. 16: BME PhD Preliminary Exam announcement for Vidhya Vijayakrishnan Nair (Y. Tong, advisor), 9:00 a.m. in MJIS 2001 and via Zoom. Research title: Human Cerebrospinal Fluid Movement across Wake and Sleep States - A Multimodal Imaging Study Mon., Aug. 21: Special BME Seminar, 9:00 a.m., MJIS 2001. Nicola Marchi, Ph.D. of the Institute de Genomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France will present "The Neurovascular Unit: From disease mechanisms to diagnostics. Wed., Aug. 30: Lilly Day at Purdue. Attention graduate students: Eli Lilly will be hosting a Purdue Day on August 30th so mark your calendar now. Please see the link below to register and find out all the fun and engaging ways you can connect with them while they are here. https://careers.lilly.com/us/en/event/6477834bc91e7957b321716a/Lilly-Day-at-Purdue<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fcareers.lilly.com%2Fus%2Fen%2Fevent%2F6477834bc91e7957b321716a%2FLilly-Day-at-Purdue&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Y%2F%2F2v3Ua29I%2Fd4jW7doP6keL%2B5ffGSrxMx9Wt0gNxV0%3D&reserved=0> Wed., Sept. 6: BMES Early Bird Registration Deadline! Register now to lock in savings with early-bird pricing for the 2023 BMES Annual Meeting (to be held in Seattle, WA, October 11-14). Thousands of biomedical engineers will attend this year's meeting to learn, collaborate, and network. As a BMES member, you can save more than 10% with reduced early bird rates, so if you're not already a member, now would be a good time to join! Click here for details: https://mailchi.mp/e3958bb463f2/o8cvhb9q5x-9335625?e=ea10e317a2<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmailchi.mp%2Fe3958bb463f2%2Fo8cvhb9q5x-9335625%3Fe%3Dea10e317a2&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=zA%2Bv4fvj6ICa3ELZQwZUsNAy1PHIIPIiC4mWcH4X47c%3D&reserved=0> NOTE: We recommend booking your room at the Hyatt Regency Seattle because it's closer to the convention center AND it's where university receptions will be held (in addition to some being held inside the convention center). Here's the link to reserve with the $259 discount rate. This rate only lasts until the allotted number of rooms have been sold. https://www.hyatt.com/en-US/group-booking/SEARS/G-BMES<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.hyatt.com%2Fen-US%2Fgroup-booking%2FSEARS%2FG-BMES&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Cs%2BWk%2BaFXtQlKNkpGszM40TVJ%2BpTyR9lYp1emhOXn1A%3D&reserved=0> Fri., Sept. 8: Abstract Submission Deadline for The Trauma THOMPSON Challenge. The primary goal of The Trauma THOMPSON Challenge is to encourage research to build better algorithms for autonomous instruction systems in uncontrolled and austere environments, especially for life-saving procedures. The envisioned algorithms include action recognition, action anticipation, procedure recognition, and visual question answering (VQA). The challenge participation details are below. Resources and further information BME Summer Seminar Series, Wed., Aug. 9, 9:30 a.m., via Zoom. You Zhou (Nan Kong, advisor) will present "Assessing the Cost-Effectiveness of Public Health Policy for Smoking Control through Microsimulation Modeling on Cardiovascular Disease" and Peter Zoss (Matthew Ward, advisor) will present "On the Structure-Function Relationships of the Mouse Common Peroneal Nerve for Bioelectronic Pain Management in Joint Disorders" Assessing the Cost-Effectiveness of public health Policy for smoking control through Microsimulation Modeling on Cardiovascular Disease Abstract: Cardiovascular Disease (CVD) is the leading cause of deaths in the US, accounting for more than 877,500 deaths every year which is one third of all deaths. To reduce its heavy burden on the healthcare system, prevention-based public health policies targeting CVD become the focus through promoting healthy behaviors and managing risk factors, as well as reducing health disparities with improved access to care for vulnerable populations. However, with limited data from the long-term large-scale population studies, public health practitioners and policymakers can't assess the cost and effectiveness of policy implementation well. Instead, microsimulation model (MSM) has been employed as a powerful tool to analyze the public health policy. In our project, we adapted the well-established and validated MSM (CVD Policy Model) for tobacco tax policy analysis in New York city with incorporation of 2 key factors: 1) illicit market and 2) secondhand smoke exposure. We simulated each individual's CVD (e.g., stroke and coronary heart disease) trajectory, and estimated the associated health cost reduction and the quality-adjusted life years (QALYs) gained by implementing tax policy to reduce cigarette consumption and secondhand smoke exposure for adults in NYC. In the model, the population socioeconomical and health profiles were sampled from NYC Health and Nutrition Examination Survey dataset and the relative risk of secondhand smoke exposure on CVD were pooled from the recent meta-analyses. Our preliminary results show that the additional tobacco tax can be cost-effective (defined as <$50,000 per QALY) even with substantial illicit market. Benefits from nonsmokers exposed to secondhand smoke shouldn't be ignored in the analysis which contributes over 27% of total incremental QALYs. Evaluation link for You Zhou: https://purdue.ca1.qualtrics.com/jfe/form/SV_0qUJQEh8KBS4Y0S<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca1.qualtrics.com%2Fjfe%2Fform%2FSV_0qUJQEh8KBS4Y0S&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=QyPnfQjzquE08qkATuAALVp9bhClmb3xIAW2PCbkVsQ%3D&reserved=0> On the Structure-Function Relationships of the Mouse Common Peroneal Nerve for Bioelectronic Pain Management in Joint Disorders Abstract: Arthritis is a common joint disorder that causes pain, swelling, and stiffness. An estimated 24% of adults in the US have some form of arthritis, including rheumatoid arthritis, osteoarthritis (OA), and posttraumatic osteoarthritis (PTOA), where the joint degenerates more rapidly following an injury. Arthritis has no cure, with pain being the most prominent and persistent symptom. Current management techniques for PTOA rely heavily on pharmaceutical approaches such as anti-inflammatory and painkiller medications, each with their own side effects and complications. Novel effective and durable intervention techniques are necessary. My research explores the structure-function relationship of nerves that supply the murine knee. My primary aim is to identify the morphology and extracellular signaling characteristics of the nerve fibers that transmit pain-related information to the central nervous system (CNS) in a PTOA model. MicroLeads cuff electrodes with 130 µm inner diameters and 0.15 mm spacing between the two platinum plated leads were implanted in the hindlimbs of 8 C57BL/6J mice to record and stimulate the common peroneal nerve, a branch of the sciatic nerve that is responsible for the sensation to portions of the leg and knee joint. Single-ended recordings from multiple cuff electrode leads showed spontaneous and evoked SFAP activity and allowed for the discrimination of afferent (sensory) and efferent (motor) activity. ECAP signals were then collected with bipolar cuff electrodes in response to a variety of stimulus parameters, giving insight into the composition of the nerve and providing a basis for feedback-controlled stimulation targeted to pain-related fibers. Targeted stimulation is key in neural-based interventions as only unmyelinated C fibers and A-delta fibers carry pain signals. These results show the potential for a targeted feedback-controlled system of peripheral nerve activity, which could lead to personalized PTOA management devices that are responsive to individual pain management needs. Evaluation link for Peter Zoss: https://purdue.ca1.qualtrics.com/jfe/form/SV_4UcA7tS8PZvpFKS<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue.ca1.qualtrics.com%2Fjfe%2Fform%2FSV_4UcA7tS8PZvpFKS&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=jDujGVjZa0U%2Bjamp3RJ%2BoxZ%2FowyGfbm3jWnmUKXYUfU%3D&reserved=0> *Join Zoom Meeting: https://purdue-edu.zoom.us/j/98231659969?pwd=T21Oa1B6QzFyQzFvckMzS1doNGlJUT09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F98231659969%3Fpwd%3DT21Oa1B6QzFyQzFvckMzS1doNGlJUT09&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=vSVmhdCi%2F1Awk89duyw9d2sTUoAgzWCcQH2Gvq4MCXY%3D&reserved=0> Meeting ID: 982 3165 9969 Passcode: biomedical BME PhD Preliminary Exam announcement for Vidhya Vijayakrishnan Nair (Y. Tong, advisor), Wed., Aug. 16, 9:00 a.m. in MJIS 2001 and via Zoom. Research title: Human Cerebrospinal Fluid Movement across Wake and Sleep States - A Multimodal Imaging Study. Thesis Committee Members: Dr. Yunjie Tong (Chair), Dr. A.J. Schwichtenberg, Dr. Vitaliy L. Rayz, Dr. Yu-Chien Wu. Abstract: Cerebrospinal Fluid (CSF) movement within the brain ventricles and subarachnoid spaces of the cranium and the spine is critical to the health and function of the central nervous system. Recent studies have highlighted the role of CSF in the pathophysiology of neurodegenerative, and neurodevelopmental disorders and the glymphatic system. CSF movement is also shown to be linked with sleep, with enhanced magnitudes of movement during Non-rapid eye movement (NREM) sleep. Regardless of the prominent role played by CSF in maintaining optimal brain health, a comprehensive understanding of the mechanisms driving CSF movement in humans across wake/sleep states has not been reached. To this end, multimodal imaging studies were designed and implemented with simultaneous acquisition of CSF and brain hemodynamics with functional Magnetic Resonance Imaging, neural activity with Electroencephalography, and non-neuronal systemic physiology with peripheral functional Near-Infrared Spectroscopy. From these studies, we show that the CSF system responds to multiple physiological forces at the same time. Both low-frequency vasomotion and respiration simultaneously interact and regulate CSF movement in humans during wakefulness. We also found that non-neuronal systemic physiology significantly influences CSF movement even when autonomic neural contributions come into play during light NREM sleep. Therefore, interventions may increase CSF movement by manipulating systemic physiology. Finally, we attempt to modulate CSF movement through manipulation of these low frequency cerebrovascular oscillations via simple breathing challenges. Preliminary results demonstrate their potential in modulating CSF movement and may be developed into clinical protocols for boosting CSF movement across pathologies where low flow is a concern. Zoom Meeting Link: https://purdue-edu.zoom.us/j/91270653117?pwd=dXhCSUZTTjFNSkJIbUNwQ0dtbytPQT09<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpurdue-edu.zoom.us%2Fj%2F91270653117%3Fpwd%3DdXhCSUZTTjFNSkJIbUNwQ0dtbytPQT09&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=avoP6Bbp%2FWaTMW6aKLGD05%2BEEFtalQViYyL5mBBftXA%3D&reserved=0> Meeting ID: 912 7065 3117 Passcode: 372987 Special BME Seminar, Mon., Aug. 21, 9:00 a.m., MJIS 2001. Nicola Marchi, Ph.D. of the Institute de Genomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France will present "The Neurovascular Unit: >From disease mechanisms to diagnostics. Abstract: The term neurovascular unit (NVU) indicates a brain-specific multi-cellular assembly controlling brain homeostasis for physiological neuronal transmission in networks. The blood-brain barrier (BBB) within the NVU is the microvascular interface that governs the exchanges between the peripheral blood and the brain parenchyma. It regulates or partakes in inflammatory modifications occurring during disease. Within this framework, we examine BBB damage as a pathophysiological entry point that allows diagnostic strategies for brain disorders. We examine human and experimental focal epilepsy as a prototype disease to study NVU dysfunctions. Bio: Nicola Marchi, PhD: Graduate Pharmacy and Pharmaceutical Chemistry, Pisa, Italy; a total of 12 years as fellow, post-doc, and PI Assistant Prof at Cleveland Clinic, Neurosurgery, and then Molecular Medicine. Then nine years PI and tenured researcher at CNRS, France. Funded as PI since 2009 (NIH R01, ANR France, Cure, Era-Net Europe, etc.). Editorial board activities, reviewers for various journals, funding organizations, etc. In 20 years: 120 publications; h-index 46. +10 book chapters. 1 Book as Editor. ~BME Hosts: Craig Goergen and Vitaliy Rayz~ Postdoctoral Fellow Opportunity - IUSM Emergency Medicine The laboratory of Dr. Nathan J. Alves, PhD, within the Department of Emergency Medicine at the Indiana University School of Medicine (IUSM), is seeking a highly motivated and independent post-doctoral research fellow. Dr. Alves is a Chemical and Biomolecular Engineer, Associate Professor and the Director of Translational Research for the Department of Emergency Medicine in addition to having an affiliate faculty appointment at Purdue University in Biomedical Engineering. The Alves Lab explores highly interdisciplinary research interests applying engineering and biophysical principles and designs to create translational technologies and treatments in the area of blood coagulation and fibrinolysis. The primary focus of research in the laboratory is to develop targeted clot digesting therapeutic agents to more safely digest clinically relevant blood clots to treat pulmonary embolism (PE, blood clots in the lungs), deep vein thrombosis (DVT), and ischemic stroke. This interdisciplinary research utilizes diverse enzyme assays, chemical synthesis, blood clot formation and digestion assays under shear, and other novel testing/delivery platforms that include multivalent branched molecules and nanoparticle drug delivery systems. Projects Include: (1) Leveraging multivalency to modulate enzyme activity and improve inhibitor selectivity (nanoparticle drug delivery and targeting). (2) Ex-vivo flowing models of clot digestion under shear using in-vivo like fluorescently labeled blood clots from human whole blood. (3) Development of novel fibrinolytic diagnostics tools to assess coagulation state. (4) Mouse models of clot formation/targeting/digestion utilizing intravital microscopy. (5) Study the effects of environmental microplastic exposure on coagulation/fibrinolysis. Projects are funded both externally and internally. For additional information and to apply, go to: https://indiana.peopleadmin.com/postings/19651<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Findiana.peopleadmin.com%2Fpostings%2F19651&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=C4HUimXHh3mbIp0jNPx3UHWMwjN2kHRsZHALRIMSkJY%3D&reserved=0> [Indiana CTSI logo and co-directors logo] REGISTRATION NOW OPEN FOR THE 2023 INDIANA CTSI ANNUAL MEETING PLEASE JOIN US ON FRIDAY, SEPTEMBER 22, 2023! Dear Indiana CTSI Colleagues, As announced today in a communication to our Indiana CTSI newsletter subscribers, registration<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D64a48a732b411d0c2653914a9390c9700ef88f4838882aed7cec562770f30bf0fdadcbbca8663e39d457feedcfe52a22b62640b2b638169e&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Ly79KHa3kAKaXOco7JdB9lNJAs7tw47d24XcDPXid%2BQ%3D&reserved=0> is open for this year's Indiana CTSI Annual Meeting to be held in-person, with virtual option, 2023 Indiana CTSI Annual Meeting on September 22, 2023. As you know, this year's 2023 August M. Watanabe Prize in Translational Research Awardee<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D64a48a732b411d0cff0679d5f37ecfaaa90dd5c13901928a73b80cf3aac5c8667cd6a5b819902927e76d0fe5584ad38994e5a413c48f2fa1&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=qCOleXeokNnWyC95FfW7Xve4y10CIPioNmw8liYuR%2Bk%3D&reserved=0>, Huda Y. Zoghbi, MD, is our keynote speaker. Dr. Zoghbi<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D64a48a732b411d0c1bc62022c033a88a3c2165789225fd8c6537727e5cb9a9e848b9482b31989500dab72de55ebb6bed567e1380f6afa587&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=CVrJ2Sm%2BLMvKyefXYVIFvyqM1WJ1ItFwRxqPDmtVUrk%3D&reserved=0>is a Distinguished Service Professor at Baylor College of Medicine, director of the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and an investigator with Howard Hughes Medicine Institute. In honor of this year's Watanabe Awardee, Dr. Zoghbi, our annual meeting theme will focus on translational neuroscience. Thus we will be showcasing the Indiana CTSI's cutting-edge research in neuroscience and related topics from across all our campuses. Importantly, as part of the day's agenda, we responded to your feedback and have dedicated a separate poster session along with more opportunities for networking and building collaborations. Our complete program is being finalized so please view the <https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D64a48a732b411d0c9425fbd69c88e0407a4176fa51d886515d157c174b4d5902068cb57902b265f2657339b3f7626fd8ef208e725d865283&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=9Cd8V82a1CThptOUgvuQVlbBE7ikGFlwSKQtCpRuX4Y%3D&reserved=0> website<https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fclick.e.iu.edu%2F%3Fqs%3D64a48a732b411d0cb627b0938d5a5cd61b3b774bd7b2f513df295ec6354a7440c8dbff237cec31ec5ff8dccbde38651b0aaf8d16a64b7694&data=05%7C01%7Cbmeroundtable-list%40ecn.purdue.edu%7C97b8ff1574214e64655308db973ee944%7C4130bd397c53419cb1e58758d6d63f21%7C0%7C0%7C638270069165022015%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=1nFN3ksv9pbwnPfbxB1go6k22DB8UZMD43r9%2FkpqgIw%3D&reserved=0> to stay informed. We are accepting submissions for in-person poster presentations. Research topics across the translational spectrum are welcome. Come showcase your research that is making a difference! The deadline for submitting poster presentation applications is 5:00 pm EDT on Wednesday, August 9th. More information is available via the registration link above - please note that you must register first in order to receive poster submission details. We look forward to seeing you on September 22 as we highlight the great work and people of the Indiana CTSI, and celebrate our efforts to advance health research in Indiana and beyond. Please register now and encourage others to do so! Sarah and Sharon Co-directors, Indiana Clinical and Translational Sciences Institute ictsi@iupui.edu<mailto:ictsi@iupui.edu?subject=> Attachments 2023 Purchase Request Form -- Bmeroundtable-list mailing list Bmeroundtable-list@ecn.purdue.edu https://engineering.purdue.edu/ECN/mailman/listinfo/bmeroundtable-list